Cancer Type Total Samples Whole Genomes Whole Exomes Original Mutations Mutations Removed by Filters Mutations After Filtering Mutations Analysed for Mutational Signatures Breast 963 119 844 736,450 18,006 718,444 713,346 Lung Adeno 660 24 636 1,963,661 117,685 1,845,976 1,797,343 Colorectum 559 - 559 272,812 53,054 219,758 216,547 Ovary 471 - 471 32,324 9,058 23,266 22,935 Melanoma 396 - 396 340,592 47,986 292,606 292,046 Head and Neck 380 - 380 70,899 11,941 58,958 58,173 Prostate 330 - 330 54,767 16,421 38,346 15,885 Kidney Clear Cell 325 - 325 42,541 14,406 28,135 27,030 Thyroid 304 - 304 10,945 5,405 5,540 5,369 Uterus 241 - 241 206,060 34,185 171,875 169,631 Glioma Low Grade 217 - 217 27,275 5,615 21,660 21,379 Stomach 212 - 212 119,277 29,813 89,464 87,799 Neuroblastoma 210 - 210 5,301 554 4,747 4,676 Lung Squamous 176 - 176 95,594 30,607 64,987 65,324 AML 154 7 147 6,269 1,128 5,141 5,030 Esophageal 146 - 146 31,023 3,770 27,253 26,555 ALL 141 1 140 9,820 449 9,371 9,346 Bladder 136 - 136 45,417 6,499 38,918 37,212 CLL 131 28 103 65,410 5,417 59,993 58,603 Pancreas 113 15 98 129,954 13,678 116,276 116,908 Pilocytic Astrocytoma 101 101 - 13,038 2,412 10,626 10,629 Kidney Papillary 100 - 100 7,600 1,251 6,349 6,094 Medulloblastoma 100 100 - 139,946 14,613 125,333 125,333 Glioblastoma 98 - 98 26,812 23,217 3,595 3,572 Liver 88 88 - 938,318 57,177 881,141 885,841 Lung Small Cell 70 - 70 18,248 3,831 14,417 14,431 Myeloma 69 - 69 4,067 514 3,553 3,537 Kidney Chromophobe 65 - 65 1,788 407 1,381 1,355 Lymphoma B-cell 48 24 24 144,006 15,367 128,639 128,680 Cervix 38 - 38 10,569 2,743 7,826 7,753 Total 7,042 507 6,535 5,570,783 547,209 5,023,574 4,938,362