Normal Chrom Pos Ref Alt Gene Transcript RNA CDS Protein Type Effect CancerGene Description DRIVER_CATEGORY Age pCR_vs_RD PreTxTumorSizeClinOrRad Tumor_size_surgery(cm) Grade group Ki67_biopsy NumPosLn ANTHRACYCLINE TAXANE geneRef DEPTH_PD13595a TUM_PILEUP_MUTS_PD13595a Pileup_MtAlpct_PD13595a ID.2 DEPTH_PD13595c TUM_PILEUP_MUTS_PD13595c Pileup_MtAlpct_PD13595c ID.3 DEPTH_PD13595d TUM_PILEUP_MUTS_PD13595d Pileup_MtAlpct_PD13595d ID.4 DEPTH_PD13595e TUM_PILEUP_MUTS_PD13595e Pileup_MtAlpct_PD13595e ID.5 DEPTH_PD13595f TUM_PILEUP_MUTS_PD13595f Pileup_MtAlpct_PD13595f ID.6 DEPTH_PD13595g TUM_PILEUP_MUTS_PD13595g Pileup_MtAlpct_PD13595g ID.7 DEPTH_PD13595h TUM_PILEUP_MUTS_PD13595h Pileup_MtAlpct_PD13595h ID.8 DEPTH_PD13595i TUM_PILEUP_MUTS_PD13595i Pileup_MtAlpct_PD13595i PD13595b 14 71200025 C G MAP3K9 CCDS32112.1 r.2103g>c c.2103G>C p.E701D Sub missense 3 UNCERTAIN_CANCER_GENE_STATUS_IN_BCA UNKNOWN 90 pS 3 3 3 3 47 11 YES YES MAP3K9:p.E701D 111 0 0 14:71200025 85 0 0 14:71200025 79 0 0 14:71200025 121 0 0 14:71200025 123 8 6.5 14:71200025 102 0 0 14:71200025 78 0 0 14:71200025 102 0 0 PD13595b 3 89480379 A T EPHA3 CCDS2922.1 r.2441a>u c.2216A>T p.D739V Sub missense 3 UNCERTAIN_CANCER_GENE_STATUS_IN_BCA UNKNOWN 90 pS 3 3 3 3 47 11 YES YES EPHA3:p.D739V 75 11 14.7 3:89480379 54 33 61.1 3:89480379 105 38 36.2 3:89480379 82 33 40.2 3:89480379 108 51 47.2 3:89480379 72 10 13.9 3:89480379 66 22 33.3 3:89480379 95 43 45.3 PD13595b 3 78656097 T C ROBO1 CCDS46872.1 r.5376a>g c.4413A>G p.K1471K Sub silent 3 SILENT SILENT 90 pS 3 3 3 3 47 11 YES YES ROBO1:p.K1471K 128 0 0 3:78656097 105 16 15.2 3:78656097 198 1 0.5 3:78656097 149 36 24.2 3:78656097 183 0 0 3:78656097 143 0 0 3:78656097 155 0 0 3:78656097 190 0 0 PD13595b 19 4102410 C T MAP2K2 CCDS12120.1 r.746g>a c.492G>A p.R164R Sub silent 3 SILENT SILENT 90 pS 3 3 3 3 47 11 YES YES MAP2K2:p.R164R 139 0 0 19:4102410 157 9 5.7 19:4102410 72 0 0 19:4102410 188 0 0 19:4102410 148 0 0 19:4102410 169 0 0 19:4102410 92 0 0 19:4102410 96 1 1 PD13595b 3 10105543 A G FANCD2 CCDS2595.1 r.1988a>g c.1895A>G p.Y632C Sub missense 3 UNCERTAIN_CANCER_GENE_STATUS_IN_BCA UNKNOWN 90 pS 3 3 3 3 47 11 YES YES FANCD2:p.Y632C 77 12 15.6 3:10105543 66 24 36.4 3:10105543 98 27 27.6 3:10105543 68 22 32.4 3:10105543 93 37 39.8 3:10105543 73 15 20.5 3:10105543 91 32 35.2 3:10105543 100 25 25 PD13595b 12 49436902 A C MLL2 CCDS44873.1 r.5601u>g c.5601T>G p.G1867G Sub silent 1 SILENT SILENT 90 pS 3 3 3 3 47 11 YES YES MLL2:p.G1867G 52 9 17.3 12:49436902 32 11 34.4 12:49436902 31 8 25.8 12:49436902 48 10 20.8 12:49436902 47 10 21.3 12:49436902 46 2 4.3 12:49436902 47 10 21.3 12:49436902 40 4 10 PD13595b 13 32913381 C G BRCA2 CCDS9344.1 r.5122c>g c.4889C>G p.S1630* Sub nonsense 1 DAMAGING_IN_BCA_GENE ONCOGENIC 90 pS 3 3 3 3 47 11 YES YES BRCA2:p.S1630* 72 0 0 13:32913381 62 0 0 13:32913381 121 0 0 13:32913381 37 0 0 13:32913381 22 4 18.2 13:32913381 95 1 1.1 13:32913381 69 0 0 13:32913381 135 0 0 PD13595b 17 7579366 G T TP53 CCDS11118.1 r.511c>a c.321C>A p.Y107* Sub nonsense 1 DAMAGING_IN_BCA_GENE ONCOGENIC 90 pS 3 3 3 3 47 11 YES YES TP53:p.Y107* 56 11 19.6 17:7579366 49 35 71.4 17:7579366 36 15 41.7 17:7579366 75 52 69.3 17:7579366 51 21 41.2 17:7579366 56 19 33.9 17:7579366 40 17 42.5 17:7579366 39 24 61.5