Normal Chrom Pos Ref Alt Gene Transcript RNA CDS Protein Type Effect CancerGene Description DRIVER_CATEGORY Age pCR_vs_RD PreTxTumorSizeClinOrRad Tumor_size_surgery(cm) Grade group Ki67_biopsy NumPosLn ANTHRACYCLINE TAXANE geneRef DEPTH_PD14750a TUM_PILEUP_MUTS_PD14750a Pileup_MtAlpct_PD14750a ID.2 DEPTH_PD14750c TUM_PILEUP_MUTS_PD14750c Pileup_MtAlpct_PD14750c ID.3 DEPTH_PD14750d TUM_PILEUP_MUTS_PD14750d Pileup_MtAlpct_PD14750d PD14750b 3 151078261 G A MED12L CCDS33876.1 r.2759-1g>a c.2721-1G>A p.? Sub ess splice 3 UNCERTAIN_CANCER_GENE_STATUS_IN_BCA UNKNOWN 29 pCR 2 0 3 1 80 0 YES YES MED12L:p.? 608 96 15.8 3:151078261 284 34 12 3:151078261 537 61 11.4 PD14750b 19 18279943 G A PIK3R2 CCDS12371.1 r.2626g>a c.2026G>A p.G676S Sub missense 3 UNCERTAIN_CANCER_GENE_STATUS_IN_BCA UNKNOWN 29 pCR 2 0 3 1 80 0 YES YES PIK3R2:p.G676S 70 3 4.3 19:18279943 77 4 5.2 19:18279943 26 5 19.2 PD14750b 12 53876800 C G MAP3K12 CCDS8860.1 r.1786g>c c.1688G>C p.R563P Sub missense 3 UNCERTAIN_CANCER_GENE_STATUS_IN_BCA UNKNOWN 29 pCR 2 0 3 1 80 0 YES YES MAP3K12:p.R563P 358 107 29.9 12:53876800 264 64 24.2 12:53876800 224 53 23.7 PD14750b 3 47079190 A C SETD2 CCDS2749.2 r.7359u>g c.7316T>G p.L2439R Sub missense 1 UNKNOWN_BCA UNKNOWN 29 pCR 2 0 3 1 80 0 YES YES SETD2:p.L2439R 162 67 41.4 3:47079190 89 37 41.6 3:47079190 154 72 46.8 PD14750b 17 7577129 A C TP53 CCDS11118.1 r.999u>g c.809T>G p.F270C Sub missense 1 ONCOGENIC_BCA_GENE ONCOGENIC 29 pCR 2 0 3 1 80 0 YES YES TP53:p.F270C 400 209 52.2 17:7577129 177 86 48.6 17:7577129 283 153 54.1