Normal Chrom Pos Ref Alt Gene Transcript RNA CDS Protein Type Effect CancerGene Description DRIVER_CATEGORY Age pCR_vs_RD PreTxTumorSizeClinOrRad Tumor_size_surgery(cm) Grade group Ki67_biopsy NumPosLn ANTHRACYCLINE TAXANE geneRef DEPTH_PD14761a TUM_PILEUP_MUTS_PD14761a Pileup_MtAlpct_PD14761a ID.2 DEPTH_PD14761c TUM_PILEUP_MUTS_PD14761c Pileup_MtAlpct_PD14761c ID.3 DEPTH_PD14761d TUM_PILEUP_MUTS_PD14761d Pileup_MtAlpct_PD14761d ID.4 DEPTH_PD14761e TUM_PILEUP_MUTS_PD14761e Pileup_MtAlpct_PD14761e ID.5 DEPTH_PD14761f TUM_PILEUP_MUTS_PD14761f Pileup_MtAlpct_PD14761f PD14761b 18 19751612 C T GATA6 CCDS11872.1 r.784c>u c.507C>T p.F169F Sub silent 3 SILENT SILENT 42 RD 6 6.5 1 3 10 3 YES YES GATA6:p.F169F 558 48 8.6 18:19751612 202 26 12.9 18:19751612 194 23 11.9 18:19751612 297 24 8.1 18:19751612 385 33 8.6 PD14761b 19 7174635 G A INSR CCDS12176.1 r.1191c>u c.1082C>T p.T361I Sub missense 3 UNCERTAIN_CANCER_GENE_STATUS_IN_BCA UNKNOWN 42 RD 6 6.5 1 3 10 3 YES YES INSR:p.T361I 311 30 9.6 19:7174635 197 26 13.2 19:7174635 150 17 11.3 19:7174635 279 13 4.7 19:7174635 320 43 13.4 PD14761b 3 178936091 G A PIK3CA CCDS43171.1 r.1790g>a c.1633G>A p.E545K Sub missense 1 CANONICAL_ONCOGENIC_BCA_GENE ONCOGENIC 42 RD 6 6.5 1 3 10 3 YES YES PIK3CA:p.E545K 66 15 22.7 3:178936091 199 51 25.6 3:178936091 92 19 20.7 3:178936091 221 26 11.8 3:178936091 204 25 12.3