Normal Chrom Pos Ref Alt Gene Transcript RNA CDS Protein Type Effect CancerGene Description DRIVER_CATEGORY Age pCR_vs_RD PreTxTumorSizeClinOrRad Tumor_size_surgery(cm) Grade group Ki67_biopsy NumPosLn ANTHRACYCLINE TAXANE geneRef DEPTH_PD14765a TUM_PILEUP_MUTS_PD14765a Pileup_MtAlpct_PD14765a ID.2 DEPTH_PD14765c TUM_PILEUP_MUTS_PD14765c Pileup_MtAlpct_PD14765c ID.3 DEPTH_PD14765d TUM_PILEUP_MUTS_PD14765d Pileup_MtAlpct_PD14765d ID.4 DEPTH_PD14765e TUM_PILEUP_MUTS_PD14765e Pileup_MtAlpct_PD14765e ID.5 DEPTH_PD14765f TUM_PILEUP_MUTS_PD14765f Pileup_MtAlpct_PD14765f PD14765b 3 178937422 T C PIK3CA CCDS43171.1 r.1967u>c c.1810T>C p.C604R Sub missense 1 ONCOGENIC_BCA_GENE ONCOGENIC 59 RD 7.2 2 3 3 50 2 YES YES PIK3CA:p.C604R 81 24 29.6 3:178937422 197 47 23.9 3:178937422 87 22 25.3 3:178937422 212 35 16.5 3:178937422 239 58 24.3 PD14765b 6 138200384 G T TNFAIP3 CCDS5187.1 r.1868g>u c.1802G>T p.R601M Sub missense 3 UNCERTAIN_CANCER_GENE_STATUS_IN_BCA UNKNOWN 59 RD 7.2 2 3 3 50 2 YES YES TNFAIP3:p.R601M 432 16 3.7 6:138200384 161 16 9.9 6:138200384 345 1 0.3 6:138200384 310 0 0 6:138200384 295 1 0.3 PD14765b 7 100416252 A G EPHB4 CCDS5706.1 r.1781u>c c.1312T>C p.S438P Sub missense 3 UNCERTAIN_CANCER_GENE_STATUS_IN_BCA UNKNOWN 59 RD 7.2 2 3 3 50 2 YES YES EPHB4:p.S438P 208 70 33.7 7:100416252 75 20 26.7 7:100416252 114 21 18.4 7:100416252 115 19 16.5 7:100416252 106 32 30.2 PD14765b 3 178952085 A G PIK3CA CCDS43171.1 r.3297a>g c.3140A>G p.H1047R Sub missense 1 CANONICAL_ONCOGENIC_BCA_GENE ONCOGENIC 59 RD 7.2 2 3 3 50 2 YES YES PIK3CA:p.H1047R 92 19 20.7 3:178952085 215 30 14 3:178952085 97 17 17.5 3:178952085 223 34 15.2 3:178952085 216 54 25 PD14765b 17 7578189 A C TP53 CCDS11118.1 r.850u>g c.660T>G p.Y220* Sub nonsense 1 DAMAGING_IN_BCA_GENE ONCOGENIC 59 RD 7.2 2 3 3 50 2 YES YES TP53:p.Y220* 442 277 62.7 17:7578189 217 121 55.8 17:7578189 256 131 51.2 17:7578189 237 86 36.3 17:7578189 226 112 49.6