Normal Chrom Pos Ref Alt Gene Transcript RNA CDS Protein Type Effect CancerGene Description DRIVER_CATEGORY Age pCR_vs_RD PreTxTumorSizeClinOrRad Tumor_size_surgery(cm) Grade group Ki67_biopsy NumPosLn ANTHRACYCLINE TAXANE geneRef DEPTH_PD9770a TUM_PILEUP_MUTS_PD9770a Pileup_MtAlpct_PD9770a ID.2 DEPTH_PD9770c TUM_PILEUP_MUTS_PD9770c Pileup_MtAlpct_PD9770c ID.3 DEPTH_PD9770d TUM_PILEUP_MUTS_PD9770d Pileup_MtAlpct_PD9770d ID.4 DEPTH_PD9770e TUM_PILEUP_MUTS_PD9770e Pileup_MtAlpct_PD9770e ID.5 DEPTH_PD9770e2 TUM_PILEUP_MUTS_PD9770e2 Pileup_MtAlpct_PD9770e2 ID.6 DEPTH_PD9770f TUM_PILEUP_MUTS_PD9770f Pileup_MtAlpct_PD9770f PD9770b 3 178952085 A G PIK3CA CCDS43171.1 r.3297a>g c.3140A>G p.H1047R Sub missense 1 CANONICAL_ONCOGENIC_BCA_GENE ONCOGENIC 62 RD 3.1 1.7 2 1 40 1 YES YES PIK3CA:p.H1047R 79 18 22.8 3:178952085 20 7 35 3:178952085 14 1 7.1 3:178952085 25 3 12 3:178952085 37 15 40.5 3:178952085 25 1 4 PD9770b 1 120496303 C A NOTCH2 CCDS908.1 r.2448g>u c.2228G>T p.C743F Sub missense 3 UNCERTAIN_CANCER_GENE_STATUS_IN_BCA UNKNOWN 62 RD 3.1 1.7 2 1 40 1 YES YES NOTCH2:p.C743F 81 0 0 1:120496303 22 0 0 1:120496303 9 0 0 1:120496303 28 0 0 1:120496303 50 0 0 1:120496303 31 4 12.9 PD9770b 20 31017154 A T ASXL1 CCDS13201.1 r.909a>u c.485A>T p.K162M Sub missense 2 UNKNOWN_OTHER UNKNOWN 62 RD 3.1 1.7 2 1 40 1 YES YES ASXL1:p.K162M 102 19 18.6 20:31017154 29 7 24.1 20:31017154 39 10 25.6 20:31017154 53 10 18.9 20:31017154 51 14 27.5 20:31017154 45 5 11.1 PD9770b 19 15285015 G T NOTCH3 CCDS12326.1 r.4676c>a c.4600C>A p.R1534R Sub silent 3 SILENT SILENT 62 RD 3.1 1.7 2 1 40 1 YES YES NOTCH3:p.R1534R 62 0 0 19:15285015 84 0 0 19:15285015 51 0 0 19:15285015 12 0 0 19:15285015 15 0 0 19:15285015 31 4 12.9 PD9770b 19 33792828 G A CEBPA ENST00000498907 r.643c>u c.493C>T p.R165C Sub missense 2 UNKNOWN_OTHER UNKNOWN 62 RD 3.1 1.7 2 1 40 1 YES YES CEBPA:p.R165C 15 0 0 19:33792828 64 0 0 19:33792828 35 0 0 19:33792828 0 0 NA 19:33792828 7 4 57.1 19:33792828 10 0 0 PD9770b 1 154951221 C T CKS1B CCDS1077.1 r.255c>u c.208C>T p.R70W Sub missense 3 UNCERTAIN_CANCER_GENE_STATUS_IN_BCA UNKNOWN 62 RD 3.1 1.7 2 1 40 1 YES YES CKS1B:p.R70W 87 22 25.3 1:154951221 24 10 41.7 1:154951221 19 8 42.1 1:154951221 87 24 27.6 1:154951221 69 38 55.1 1:154951221 62 13 21 PD9770b 17 7577022 G A TP53 CCDS11118.1 r.1106c>u c.916C>T p.R306* Sub nonsense 1 DAMAGING_IN_BCA_GENE ONCOGENIC 62 RD 3.1 1.7 2 1 40 1 YES YES TP53:p.R306* 122 41 33.6 17:7577022 28 16 57.1 17:7577022 45 13 28.9 17:7577022 26 4 15.4 17:7577022 39 21 53.8 17:7577022 47 7 14.9