Normal Chrom Pos Ref Alt Gene Transcript RNA CDS Protein Type Effect CancerGene Description DRIVER_CATEGORY Age pCR_vs_RD PreTxTumorSizeClinOrRad Tumor_size_surgery(cm) Grade group Ki67_biopsy NumPosLn ANTHRACYCLINE TAXANE geneRef DEPTH_PD9776a TUM_PILEUP_MUTS_PD9776a Pileup_MtAlpct_PD9776a ID.2 DEPTH_PD9776c2 TUM_PILEUP_MUTS_PD9776c2 Pileup_MtAlpct_PD9776c2 ID.3 DEPTH_PD9776d TUM_PILEUP_MUTS_PD9776d Pileup_MtAlpct_PD9776d ID.4 DEPTH_PD9776e TUM_PILEUP_MUTS_PD9776e Pileup_MtAlpct_PD9776e PD9776b 17 7577106 G A TP53 CCDS11118.1 r.1022c>u c.832C>T p.P278S Sub missense 1 ONCOGENIC_BCA_GENE ONCOGENIC 54 pCR 3.5 0 2 1 90 0 YES YES TP53:p.P278S 117 42 35.9 17:7577106 65 13 20 17:7577106 28 10 35.7 17:7577106 13 7 53.8 PD9776b 3 150877637 C A MED12L CCDS33876.1 r.894c>a c.856C>A p.Q286K Sub missense 3 UNCERTAIN_CANCER_GENE_STATUS_IN_BCA UNKNOWN 54 pCR 3.5 0 2 1 90 0 YES YES MED12L:p.Q286K 203 53 26.1 3:150877637 58 13 22.4 3:150877637 53 19 35.8 3:150877637 22 5 22.7 PD9776b 22 30064364 A G NF2 CCDS13861.1 r.1369a>g c.928A>G p.R310G Sub missense 3 UNCERTAIN_CANCER_GENE_STATUS_IN_BCA UNKNOWN 54 pCR 3.5 0 2 1 90 0 YES YES NF2:p.R310G 102 35 34.3 22:30064364 43 9 20.9 22:30064364 23 5 21.7 22:30064364 11 1 9.1 PD9776b X 53240834 C A KDM5C CCDS14351.1 r.1779g>u c.1246G>T p.V416L Sub missense 2 UNKNOWN_OTHER UNKNOWN 54 pCR 3.5 0 2 1 90 0 YES YES KDM5C:p.V416L 69 15 21.7 X:53240834 37 3 8.1 X:53240834 11 5 45.5 X:53240834 2 0 0 PD9776b 20 61869927 T A BIRC7 CCDS13513.1 r.752u>a c.538T>A p.W180R Sub missense 3 UNCERTAIN_CANCER_GENE_STATUS_IN_BCA UNKNOWN 54 pCR 3.5 0 2 1 90 0 YES YES BIRC7:p.W180R 207 43 20.8 20:61869927 67 16 23.9 20:61869927 17 2 11.8 20:61869927 7 3 42.9