Optical Mapping is a system that produces ordered restriction maps from individual molecules of genomic DNA: a single-molecule realization of traditional restriction fragment length polymorphism mapping. Each single-molecule restriction map is a direct measurement of the source genome, free from biases introduced by cloning, amplification, or hybridization. This track presents the results of an analysis of optical map fragment-size data. [See 'High-resolution human genome structure by single-molecule analysis', PNAS 107(24):10848-53. doi: 10.1073/pnas.0914638107].
Optical mapping produces restriction fragments which occur in a known order within contigs, derived from specific cell lines. Each track corresponds to an analysis of OM data from a single cell line. Each contig is presented as a horizontal line, with restriction cut-sites dividing fragments being displayed as vertical lines along that contig. (In technical terms, each contig is encoded in the BigBed file as if it were a single gene, with cut sites between fragments being represented as very short exons within that gene.) Where there is a space between the placement of successive restriction fragments according to this analysis, this is represented as a thicker vertical bar spanning the gap between the fragments.
Optical mapping. See [Ref 'High-resolution human genome structure by single-molecule analysis', PNAS 107(24):10848-53. doi: 10.1073/pnas.0914638107].
Data generated by the Genome Reference Consortium. Contact us via genomereference.org or by emailing grc-help@sanger.ac.uk
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