Optical Mapping is a system that produces ordered restriction maps from individual molecules of genomic DNA: a single-molecule realization of traditional restriction fragment length polymorphism mapping. Each single-molecule restriction map is a direct measurement of the source genome, free from biases introduced by cloning, amplification, or hybridization. This track presents the results of an analysis of optical map fragment-size data. Specifically, it displays the locations of restriction fragments that do not have a corresponding fragments in the reference assembly, implying a possible deletion in the reference assembly. [See 'High-resolution human genome structure by single-molecule analysis', PNAS 107(24):10848-53. doi: 10.1073/pnas.0914638107].
Optical mapping produces restriction fragments which occur in a known order within contigs, derived from specific cell lines. Each track corresponds to an analysis of OM data from a single cell line. This track presents the locations (according the analysis) of restriction fragments that have no corresponding fragment in the assembly. The location of each fragment or group of fragments is shown as a single vertical bar. The size of the fragment is not represented by the glyph in the browser, but is shown as one of its data fields.
Optical mapping. See [Ref 'High-resolution human genome structure by single-molecule analysis', PNAS 107(24):10848-53. doi: 10.1073/pnas.0914638107].
Data generated by the Genome Reference Consortium. Contact us via genomereference.org or by emailing grc-help@sanger.ac.uk
Church DM, Schneider VA, Graves T, Auger K, Cunningham F, et al. (2011) Modernizing Reference Genome Assemblies. PLoS Biol 9(7): e1001091. doi:10.1371/journal.pbio.1001091