64 of 176 pathway holes were filled (36.4%).
|
Hole-filler
|
Hole EC#
|
P(has-function)
|
All functions of hole-filler
|
Pathway(s) requiring this reaction
|
Date filled
|
|
gene:NECAME_01073
|
none
|
0.977
|
gene:NECAME_01073
|
L-Ndelta-acetylornithine biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_01330
|
5.1.2.3
|
1.000
|
gene:NECAME_01330
|
fatty acid beta-oxidation I
|
10-Apr-2015
|
|
gene:NECAME_01330
|
5.3.3.8
|
1.000
|
gene:NECAME_01330
|
fatty acid beta-oxidation I
|
10-Apr-2015
|
|
gene:NECAME_01770
|
2.4.1.102
|
0.927
|
gene:NECAME_01770
|
mucin core 1 and core 2 O-glycosylation
|
10-Apr-2015
|
|
gene:NECAME_02144
|
5.3.3.8
|
0.997
|
gene:NECAME_02144
|
fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)
|
10-Apr-2015
|
|
gene:NECAME_02204
|
3.1.3.-
|
0.983
|
gene:NECAME_02204
|
3-phosphoinositide biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_02461
|
2.7.1.36
|
0.921
|
gene:NECAME_02461
|
mevalonate pathway I
|
10-Apr-2015
|
|
gene:NECAME_02907
|
5.4.99.2
|
0.986
|
gene:NECAME_02907
|
propionyl CoA degradation
|
10-Apr-2015
|
|
gene:NECAME_03391
|
3.1.3.57
|
1.000
|
gene:NECAME_03391
|
D-myo-inositol (1,4,5)-trisphosphate degradation
|
10-Apr-2015
|
|
gene:NECAME_03302
|
4.1.99.18
|
0.970
|
gene:NECAME_03302
|
molybdenum cofactor biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_04015
|
1.14.19.-
|
0.927
|
gene:NECAME_04015
|
docosahexanoate biosynthesis I
|
10-Apr-2015
|
|
gene:NECAME_03861
|
1.1.1.330
|
0.946
|
gene:NECAME_03861
|
very long chain fatty acid biosynthesis I
|
10-Apr-2015
|
|
gene:NECAME_03861
|
1.1.1.330
|
0.946
|
gene:NECAME_03861
|
very long chain fatty acid biosynthesis II
|
10-Apr-2015
|
|
gene:NECAME_03861
|
1.1.1.330
|
0.946
|
gene:NECAME_03861
|
very long chain fatty acid biosynthesis II
|
10-Apr-2015
|
|
gene:NECAME_03861
|
1.1.1.330
|
0.946
|
gene:NECAME_03861
|
very long chain fatty acid biosynthesis II
|
10-Apr-2015
|
|
gene:NECAME_03861
|
1.1.1.330
|
0.946
|
gene:NECAME_03861
|
very long chain fatty acid biosynthesis II
|
10-Apr-2015
|
|
gene:NECAME_03852
|
2.6.1.-
|
0.998
|
gene:NECAME_03852
|
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation
|
10-Apr-2015
|
|
gene:NECAME_03852
|
3.5.1.9
|
0.974
|
gene:NECAME_03852
|
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
|
10-Apr-2015
|
|
gene:NECAME_05225
|
none
|
0.967
|
gene:NECAME_05225
|
docosahexanoate biosynthesis II
|
10-Apr-2015
|
|
gene:NECAME_05225
|
1.14.19.-
|
0.927
|
gene:NECAME_05225
|
docosahexanoate biosynthesis II
|
10-Apr-2015
|
|
gene:NECAME_05225
|
1.14.19.3
|
0.970
|
gene:NECAME_05225
|
gamma-linolenate biosynthesis II (animals),
docosahexanoate biosynthesis I
|
10-Apr-2015
|
|
gene:NECAME_05231
|
2.7.7.2
|
0.999
|
gene:NECAME_05231
|
flavin biosynthesis IV (mammalian)
|
10-Apr-2015
|
|
gene:NECAME_06269
|
2.7.1.149
|
0.998
|
gene:NECAME_06269
|
D-myo-inositol (1,4,5)-trisphosphate biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_06853
|
2.3.3.10
|
0.940
|
gene:NECAME_06853
|
mevalonate pathway I
|
10-Apr-2015
|
|
gene:NECAME_07705
|
1.2.1.-
|
0.995
|
gene:NECAME_07705
|
isoleucine degradation I
|
10-Apr-2015
|
|
gene:NECAME_07705
|
1.2.1.-
|
0.995
|
gene:NECAME_07705
|
leucine degradation I
|
10-Apr-2015
|
|
gene:NECAME_06715
|
1.3.8.-
|
0.995
|
gene:NECAME_06715
|
valine degradation I
|
10-Apr-2015
|
|
gene:NECAME_06715
|
1.3.8.5
|
0.995
|
gene:NECAME_06715
|
isoleucine degradation I
|
10-Apr-2015
|
|
gene:NECAME_08113
|
2.7.7.80
|
0.921
|
gene:NECAME_08113
|
molybdenum cofactor biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_08182
|
2.3.1.7
|
1.000
|
gene:NECAME_08182
|
mitochondrial L-carnitine shuttle
|
10-Apr-2015
|
|
gene:NECAME_07549
|
2.4.1.143
|
0.986
|
gene:NECAME_07549
|
mannosyl-glycoprotein N-acetylglucosaminyltransferases
|
10-Apr-2015
|
|
gene:NECAME_07917
|
1.11.1.12
|
0.999
|
gene:NECAME_07917
|
glutathione redox reactions I
|
10-Apr-2015
|
|
gene:NECAME_07962
|
none
|
0.921
|
gene:NECAME_07962
|
tetrahydrobiopterin biosynthesis II
|
10-Apr-2015
|
|
gene:NECAME_08390
|
1.4.3.16
|
0.921
|
gene:NECAME_08390
|
NAD biosynthesis I (from aspartate)
|
10-Apr-2015
|
|
gene:NECAME_08416
|
3.2.1.33
|
0.995
|
gene:NECAME_08416
|
glycogenolysis II
|
10-Apr-2015
|
|
gene:NECAME_08416
|
2.4.1.25
|
0.995
|
gene:NECAME_08416
|
glycogenolysis II
|
10-Apr-2015
|
|
gene:NECAME_08870
|
none
|
0.993
|
gene:NECAME_08870
|
folate transformations I
|
10-Apr-2015
|
|
gene:NECAME_08623
|
3.2.1.114
|
0.963
|
gene:NECAME_08623
|
mannosyl-glycoprotein N-acetylglucosaminyltransferases
|
10-Apr-2015
|
|
gene:NECAME_09686
|
2.3.1.9
|
0.999
|
gene:NECAME_09686
|
mevalonate pathway I,
glutaryl-CoA degradation
|
10-Apr-2015
|
|
gene:NECAME_09523
|
none
|
0.955
|
gene:NECAME_09523
|
[2Fe-2S] iron-sulfur cluster biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_09526
|
6.3.1.5
|
0.980
|
gene:NECAME_09526
|
NAD biosynthesis I (from aspartate)
|
10-Apr-2015
|
|
gene:NECAME_10391
|
1.2.1.25
|
0.999
|
gene:NECAME_10391
|
valine degradation I
|
10-Apr-2015
|
|
gene:NECAME_11537
|
2.4.1.174
|
1.000
|
gene:NECAME_11537
|
chondroitin and dermatan biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_11946
|
5.5.1.4
|
0.985
|
gene:NECAME_11946
|
myo-inositol biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_11316
|
1.1.1.300
|
0.984
|
gene:NECAME_11316
|
retinol biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_12745
|
3.5.1.111
|
0.974
|
gene:NECAME_12745
|
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation
|
10-Apr-2015
|
|
gene:NECAME_12882
|
4.1.1.1
|
0.929
|
gene:NECAME_12882
|
chitin degradation to ethanol
|
10-Apr-2015
|
|
gene:NECAME_12361
|
none
|
0.993
|
gene:NECAME_12361
|
[2Fe-2S] iron-sulfur cluster biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_12361
|
none
|
0.993
|
gene:NECAME_12361
|
[2Fe-2S] iron-sulfur cluster biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_12361
|
none
|
0.993
|
gene:NECAME_12361
|
[2Fe-2S] iron-sulfur cluster biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_14035
|
2.7.1.154
|
1.000
|
gene:NECAME_14035
|
3-phosphoinositide biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_14035
|
2.7.1.153
|
0.998
|
gene:NECAME_14035
|
3-phosphoinositide biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_13175
|
2.3.1.9
|
0.987
|
gene:NECAME_13175
|
isoleucine degradation I
|
10-Apr-2015
|
|
gene:NECAME_14151
|
1.1.1.38/1.1.1.39
|
0.977
|
gene:NECAME_14151
|
chitin degradation to ethanol
|
10-Apr-2015
|
|
gene:NECAME_14527
|
2.7.8.2
|
0.927
|
gene:NECAME_14527
|
phosphatidylcholine resynthesis via glycerophosphocholine
|
10-Apr-2015
|
|
gene:NECAME_15165
|
5.3.3.-
|
0.967
|
gene:NECAME_15165
|
fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)
|
10-Apr-2015
|
|
gene:NECAME_14603
|
4.1.1.33
|
0.980
|
gene:NECAME_14603
|
mevalonate pathway I
|
10-Apr-2015
|
|
gene:NECAME_15237
|
1.14.13.9
|
0.969
|
gene:NECAME_15237
|
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
|
10-Apr-2015
|
|
gene:NECAME_15093
|
2.7.1.137
|
0.992
|
gene:NECAME_15093
|
3-phosphoinositide biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_15663
|
1.14.99.36
|
0.982
|
gene:NECAME_15663
|
retinol biosynthesis
|
10-Apr-2015
|
|
gene:NECAME_15967
|
4.3.2.-
|
0.924
|
gene:NECAME_15967
|
sphingosine and sphingosine-1-phosphate metabolism
|
10-Apr-2015
|
|
gene:NECAME_16340
|
2.3.1.29
|
1.000
|
gene:NECAME_16340
|
threonine degradation II
|
10-Apr-2015
|
|
gene:NECAME_16649
|
2.4.1.146
|
0.936
|
gene:NECAME_16649
|
mucin core 1 and core 2 O-glycosylation
|
10-Apr-2015
|
|
gene:NECAME_16043
|
2.1.2.2
|
0.917
|
gene:NECAME_16043
|
5-aminoimidazole ribonucleotide biosynthesis I
|
10-Apr-2015
|