53 of 128 pathway holes were filled (41.4%).
|
Hole-filler
|
Hole EC#
|
P(has-function)
|
All functions of hole-filler
|
Pathway(s) requiring this reaction
|
Date filled
|
|
HYM_GENE08062:gene
|
2.4.2.2/2.4.2.3
|
1.000
|
HYM_GENE08062:gene
|
pyrimidine deoxyribonucleosides degradation
|
26-Feb-2015
|
|
HYM_GENE08787:gene
|
3.1.1.1
|
0.992
|
HYM_GENE08787:gene
|
retinol biosynthesis
|
26-Feb-2015
|
|
HYM_GENE08787:gene
|
3.1.1.1
|
0.992
|
HYM_GENE08787:gene
|
retinol biosynthesis
|
26-Feb-2015
|
|
HYM_GENE00067:gene
|
2.7.1.150
|
0.992
|
HYM_GENE00067:gene
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
HYM_GENE07400:gene
|
6.3.4.3
|
0.999
|
HYM_GENE07400:gene
|
folate transformations I,
formylTHF biosynthesis I
|
26-Feb-2015
|
|
HYM_GENE03993:gene
|
2.9.1.2
|
0.996
|
HYM_GENE03993:gene
|
selenocysteine biosynthesis II (archaea and eukaryotes)
|
26-Feb-2015
|
|
HYM_GENE03993:gene
|
2.9.1.2
|
0.996
|
HYM_GENE03993:gene
|
selenocysteine biosynthesis II (archaea and eukaryotes)
|
26-Feb-2015
|
|
HYM_GENE04981:gene
|
1.13.11.52
|
0.987
|
HYM_GENE04981:gene
|
tryptophan degradation XI (mammalian, via kynurenine)
|
26-Feb-2015
|
|
HYM_GENE04981:gene
|
1.13.11.11
|
0.987
|
HYM_GENE04981:gene
|
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
|
26-Feb-2015
|
|
HYM_GENE04981:gene
|
1.13.11.52
|
0.987
|
HYM_GENE04981:gene
|
tryptophan degradation XI (mammalian, via kynurenine)
|
26-Feb-2015
|
|
HYM_GENE04981:gene
|
1.13.11.11
|
0.987
|
HYM_GENE04981:gene
|
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
|
26-Feb-2015
|
|
HYM_GENE01866:gene
|
4.2.1.134
|
0.983
|
HYM_GENE01866:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE01866:gene
|
4.2.1.134
|
0.983
|
HYM_GENE01866:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE01866:gene
|
4.2.1.134
|
0.983
|
HYM_GENE01866:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE01866:gene
|
4.2.1.134
|
0.983
|
HYM_GENE01866:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE01866:gene
|
4.2.1.134
|
0.983
|
HYM_GENE01866:gene
|
very long chain fatty acid biosynthesis I
|
26-Feb-2015
|
|
HYM_GENE01866:gene
|
4.2.1.134
|
0.983
|
HYM_GENE01866:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE01866:gene
|
4.2.1.134
|
0.983
|
HYM_GENE01866:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE01866:gene
|
4.2.1.134
|
0.983
|
HYM_GENE01866:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE01866:gene
|
4.2.1.134
|
0.983
|
HYM_GENE01866:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE01866:gene
|
4.2.1.134
|
0.983
|
HYM_GENE01866:gene
|
very long chain fatty acid biosynthesis I
|
26-Feb-2015
|
|
HYM_GENE05833:gene
|
2.4.2.26
|
0.999
|
HYM_GENE05833:gene
|
glycoaminoglycan-protein linkage region biosynthesis
|
26-Feb-2015
|
|
HYM_GENE05833:gene
|
2.4.2.26
|
0.999
|
HYM_GENE05833:gene
|
glycoaminoglycan-protein linkage region biosynthesis
|
26-Feb-2015
|
|
HYM_GENE00277:gene
|
2.4.1.186
|
0.996
|
HYM_GENE00277:gene
|
glycogen biosynthesis II (from UDP-D-Glucose)
|
26-Feb-2015
|
|
HYM_GENE00277:gene
|
2.4.1.186
|
0.996
|
HYM_GENE00277:gene
|
glycogen biosynthesis II (from UDP-D-Glucose)
|
26-Feb-2015
|
|
HYM_GENE00277:gene
|
2.4.1.186
|
0.996
|
HYM_GENE00277:gene
|
glycogen biosynthesis II (from UDP-D-Glucose)
|
26-Feb-2015
|
|
HYM_GENE00277:gene
|
2.4.1.186
|
0.996
|
HYM_GENE00277:gene
|
glycogen biosynthesis II (from UDP-D-Glucose)
|
26-Feb-2015
|
|
HYM_GENE05978:gene
|
4.1.1.33
|
0.999
|
HYM_GENE05978:gene
|
mevalonate pathway I
|
26-Feb-2015
|
|
HYM_GENE05978:gene
|
4.1.1.33
|
0.999
|
HYM_GENE05978:gene
|
mevalonate pathway I
|
26-Feb-2015
|
|
HYM_GENE05299:gene
|
3.4.19.9
|
0.995
|
HYM_GENE05299:gene
|
4-hydroxy-2-nonenal detoxification
|
26-Feb-2015
|
|
HYM_GENE07244:gene
|
2.7.7.23
|
0.997
|
HYM_GENE07244:gene
|
UDP-N-acetyl-D-glucosamine biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE07244:gene
|
2.7.7.23
|
0.997
|
HYM_GENE07244:gene
|
UDP-N-acetyl-D-glucosamine biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE01843:gene
|
2.7.1.154
|
0.986
|
HYM_GENE01843:gene
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
HYM_GENE01843:gene
|
2.7.1.153
|
0.999
|
HYM_GENE01843:gene
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
HYM_GENE01843:gene
|
2.7.1.154
|
0.986
|
HYM_GENE01843:gene
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
HYM_GENE01843:gene
|
2.7.1.153
|
0.999
|
HYM_GENE01843:gene
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
HYM_GENE09825:gene
|
none
|
0.979
|
HYM_GENE09825:gene
|
folate transformations I,
formylTHF biosynthesis I
|
26-Feb-2015
|
|
HYM_GENE01059:gene
|
2.6.1.7
|
0.995
|
HYM_GENE01059:gene
|
tryptophan degradation XI (mammalian, via kynurenine)
|
26-Feb-2015
|
|
HYM_GENE05131:gene
|
3.4.13.18
|
0.997
|
HYM_GENE05131:gene
|
gamma-glutamyl cycle
|
26-Feb-2015
|
|
HYM_GENE04762:gene
|
2.7.4.2
|
0.987
|
HYM_GENE04762:gene
|
mevalonate pathway I
|
26-Feb-2015
|
|
HYM_GENE04762:gene
|
2.7.4.2
|
0.987
|
HYM_GENE04762:gene
|
mevalonate pathway I
|
26-Feb-2015
|
|
HYM_GENE08202:gene
|
1.5.99.8
|
0.996
|
HYM_GENE08202:gene
|
L-Ndelta-acetylornithine biosynthesis
|
26-Feb-2015
|
|
HYM_GENE08202:gene
|
1.5.99.8
|
0.996
|
HYM_GENE08202:gene
|
L-Ndelta-acetylornithine biosynthesis
|
26-Feb-2015
|
|
HYM_GENE01294:gene
|
4.1.1.23
|
1.000
|
HYM_GENE01294:gene
|
UMP biosynthesis
|
26-Feb-2015
|
|
HYM_GENE00846:gene
|
none
|
0.992
|
HYM_GENE00846:gene
|
TCA cycle VII (mammalian)
|
26-Feb-2015
|
|
HYM_GENE09989:gene
|
1.1.1.94
|
0.983
|
HYM_GENE09989:gene
|
CDP-diacylglycerol biosynthesis I
|
26-Feb-2015
|
|
HYM_GENE02844:gene
|
1.1.1.330
|
0.997
|
HYM_GENE02844:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE02844:gene
|
1.1.1.330
|
0.997
|
HYM_GENE02844:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE02844:gene
|
1.1.1.330
|
0.997
|
HYM_GENE02844:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE02844:gene
|
1.1.1.330
|
0.997
|
HYM_GENE02844:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE02844:gene
|
1.1.1.330
|
0.997
|
HYM_GENE02844:gene
|
very long chain fatty acid biosynthesis I
|
26-Feb-2015
|
|
HYM_GENE02844:gene
|
1.1.1.330
|
0.997
|
HYM_GENE02844:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE02844:gene
|
1.1.1.330
|
0.997
|
HYM_GENE02844:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE02844:gene
|
1.1.1.330
|
0.997
|
HYM_GENE02844:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE02844:gene
|
1.1.1.330
|
0.997
|
HYM_GENE02844:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE02844:gene
|
1.1.1.330
|
0.997
|
HYM_GENE02844:gene
|
very long chain fatty acid biosynthesis I
|
26-Feb-2015
|
|
HYM_GENE02692:gene
|
3.1.3.-
|
0.987
|
HYM_GENE02692:gene
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
HYM_GENE02692:gene
|
3.1.3.-
|
0.987
|
HYM_GENE02692:gene
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
HYM_GENE01452:gene
|
1.3.3.4
|
0.988
|
HYM_GENE01452:gene
|
heme biosynthesis from uroporphyrinogen-III I
|
26-Feb-2015
|
|
HYM_GENE01452:gene
|
1.3.3.4
|
0.988
|
HYM_GENE01452:gene
|
heme biosynthesis from uroporphyrinogen-III I
|
26-Feb-2015
|
|
HYM_GENE05270:gene
|
5.4.2.3
|
0.986
|
HYM_GENE05270:gene
|
UDP-N-acetyl-D-glucosamine biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE05270:gene
|
5.4.2.3
|
0.986
|
HYM_GENE05270:gene
|
UDP-N-acetyl-D-glucosamine biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE03222:gene
|
6.4.1.1
|
0.977
|
HYM_GENE03222:gene
|
gluconeogenesis III
|
26-Feb-2015
|
|
HYM_GENE03222:gene
|
6.4.1.1
|
0.977
|
HYM_GENE03222:gene
|
gluconeogenesis III
|
26-Feb-2015
|
|
HYM_GENE02104:gene
|
2.7.1.36
|
0.926
|
HYM_GENE02104:gene
|
mevalonate pathway I
|
26-Feb-2015
|
|
HYM_GENE02104:gene
|
2.7.1.36
|
0.926
|
HYM_GENE02104:gene
|
mevalonate pathway I
|
26-Feb-2015
|
|
HYM_GENE08999:gene
|
6.3.2.5
|
0.994
|
HYM_GENE08999:gene
|
coenzyme A biosynthesis
|
26-Feb-2015
|
|
HYM_GENE09292:gene
|
1.1.1.300
|
0.996
|
HYM_GENE09292:gene
|
retinol biosynthesis
|
26-Feb-2015
|
|
HYM_GENE09292:gene
|
1.1.1.300
|
0.996
|
HYM_GENE09292:gene
|
retinol biosynthesis
|
26-Feb-2015
|
|
HYM_GENE00108:gene
|
1.3.1.93
|
0.997
|
HYM_GENE00108:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE00108:gene
|
1.3.1.93
|
0.997
|
HYM_GENE00108:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE00108:gene
|
1.3.1.93
|
0.997
|
HYM_GENE00108:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE00108:gene
|
1.3.1.93
|
0.997
|
HYM_GENE00108:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE00108:gene
|
1.3.1.93
|
0.997
|
HYM_GENE00108:gene
|
very long chain fatty acid biosynthesis I
|
26-Feb-2015
|
|
HYM_GENE00108:gene
|
1.3.1.93
|
0.997
|
HYM_GENE00108:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE00108:gene
|
1.3.1.93
|
0.997
|
HYM_GENE00108:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE00108:gene
|
1.3.1.93
|
0.997
|
HYM_GENE00108:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE00108:gene
|
1.3.1.93
|
0.997
|
HYM_GENE00108:gene
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
HYM_GENE00108:gene
|
1.3.1.93
|
0.997
|
HYM_GENE00108:gene
|
very long chain fatty acid biosynthesis I
|
26-Feb-2015
|
|
HYM_GENE07964:gene
|
2.7.1.137
|
0.972
|
HYM_GENE07964:gene
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
HYM_GENE07964:gene
|
2.7.1.137
|
0.972
|
HYM_GENE07964:gene
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
HYM_GENE02549:gene
|
5.1.99.6
|
0.999
|
HYM_GENE02549:gene
|
NADH repair
|
26-Feb-2015
|
|
HYM_GENE06686:gene
|
2.7.1.74
|
0.988
|
HYM_GENE06686:gene
|
pyrimidine deoxyribonucleosides salvage
|
26-Feb-2015
|
|
HYM_GENE06686:gene
|
2.7.1.74
|
0.988
|
HYM_GENE06686:gene
|
pyrimidine deoxyribonucleosides salvage
|
26-Feb-2015
|
|
HYM_GENE02378:gene
|
2.7.1.149
|
0.999
|
HYM_GENE02378:gene
|
D-myo-inositol (1,4,5)-trisphosphate biosynthesis
|
26-Feb-2015
|
|
HYM_GENE06802:gene
|
2.4.1.133
|
0.992
|
HYM_GENE06802:gene
|
glycoaminoglycan-protein linkage region biosynthesis
|
26-Feb-2015
|
|
HYM_GENE06802:gene
|
2.4.1.133
|
0.992
|
HYM_GENE06802:gene
|
glycoaminoglycan-protein linkage region biosynthesis
|
26-Feb-2015
|
|
HYM_GENE04142:gene
|
3.6.1.15
|
0.926
|
HYM_GENE04142:gene
|
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides biosynthesis from CTP
|
26-Feb-2015
|
|
HYM_GENE04142:gene
|
3.6.1.15
|
0.926
|
HYM_GENE04142:gene
|
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides biosynthesis from CTP
|
26-Feb-2015
|
|
HYM_GENE06560:gene
|
3.1.3.57
|
0.994
|
HYM_GENE06560:gene
|
D-myo-inositol (1,4,5)-trisphosphate degradation
|
26-Feb-2015
|
|
HYM_GENE09476:gene
|
2.7.7.2
|
0.999
|
HYM_GENE09476:gene
|
flavin biosynthesis IV (mammalian)
|
26-Feb-2015
|