60 of 134 pathway holes were filled (44.8%).
|
Hole-filler
|
Hole EC#
|
P(has-function)
|
All functions of hole-filler
|
Pathway(s) requiring this reaction
|
Date filled
|
|
gene:Smp_030500
|
1.1.1.94
|
0.987
|
gene:Smp_030500
|
CDP-diacylglycerol biosynthesis I
|
26-Feb-2015
|
|
gene:Smp_009430
|
1.1.1.330
|
0.992
|
gene:Smp_009430
|
very long chain fatty acid biosynthesis I
|
26-Feb-2015
|
|
gene:Smp_009430
|
1.1.1.330
|
0.992
|
gene:Smp_009430
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_009430
|
1.1.1.330
|
0.992
|
gene:Smp_009430
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_009430
|
1.1.1.330
|
0.992
|
gene:Smp_009430
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_009430
|
1.1.1.330
|
0.992
|
gene:Smp_009430
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_009430
|
1.1.1.330
|
0.992
|
gene:Smp_009430
|
very long chain fatty acid biosynthesis I
|
26-Feb-2015
|
|
gene:Smp_009430
|
1.1.1.330
|
0.992
|
gene:Smp_009430
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_009430
|
1.1.1.330
|
0.992
|
gene:Smp_009430
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_009430
|
1.1.1.330
|
0.992
|
gene:Smp_009430
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_009430
|
1.1.1.330
|
0.992
|
gene:Smp_009430
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_128310
|
2.4.2.26
|
0.958
|
gene:Smp_128310
|
glycoaminoglycan-protein linkage region biosynthesis
|
26-Feb-2015
|
|
gene:Smp_128310
|
2.4.2.26
|
0.958
|
gene:Smp_128310
|
glycoaminoglycan-protein linkage region biosynthesis
|
26-Feb-2015
|
|
gene:Smp_170300
|
1.1.1.300
|
0.987
|
gene:Smp_170300
|
retinol biosynthesis
|
26-Feb-2015
|
|
gene:Smp_170300
|
1.1.1.300
|
0.987
|
gene:Smp_170300
|
retinol biosynthesis
|
26-Feb-2015
|
|
gene:Smp_048430
|
1.8.1.7
|
0.983
|
gene:Smp_048430
|
glutathione redox reactions I
|
26-Feb-2015
|
|
gene:Smp_072460
|
2.7.4.2
|
0.944
|
gene:Smp_072460
|
mevalonate pathway I
|
26-Feb-2015
|
|
gene:Smp_072460
|
2.7.4.2
|
0.944
|
gene:Smp_072460
|
mevalonate pathway I
|
26-Feb-2015
|
|
gene:Smp_133900
|
1.13.11.52
|
0.967
|
gene:Smp_133900
|
tryptophan degradation XI (mammalian, via kynurenine)
|
26-Feb-2015
|
|
gene:Smp_133900
|
1.13.11.11
|
0.967
|
gene:Smp_133900
|
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
|
26-Feb-2015
|
|
gene:Smp_133900
|
1.13.11.52
|
0.967
|
gene:Smp_133900
|
tryptophan degradation XI (mammalian, via kynurenine)
|
26-Feb-2015
|
|
gene:Smp_133900
|
1.13.11.11
|
0.967
|
gene:Smp_133900
|
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
|
26-Feb-2015
|
|
gene:Smp_022540
|
3.1.3.78
|
0.987
|
gene:Smp_022540
|
D-myo-inositol-5-phosphate metabolism,
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Smp_007640
|
3.2.1.33
|
0.972
|
gene:Smp_007640
|
glycogen degradation II
|
26-Feb-2015
|
|
gene:Smp_007640
|
2.4.1.25
|
0.972
|
gene:Smp_007640
|
glycogen degradation II
|
26-Feb-2015
|
|
gene:Smp_007640
|
3.2.1.33
|
0.972
|
gene:Smp_007640
|
glycogen degradation II
|
26-Feb-2015
|
|
gene:Smp_007640
|
2.4.1.25
|
0.972
|
gene:Smp_007640
|
glycogen degradation II
|
26-Feb-2015
|
|
gene:Smp_213720
|
3.5.1.9
|
1.000
|
gene:Smp_213720
|
tryptophan degradation XI (mammalian, via kynurenine),
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
|
26-Feb-2015
|
|
gene:Smp_128690
|
none
|
0.998
|
gene:Smp_128690
|
folate transformations I,
formylTHF biosynthesis I
|
26-Feb-2015
|
|
gene:Smp_128690
|
none
|
0.998
|
gene:Smp_128690
|
folate transformations I,
formylTHF biosynthesis I
|
26-Feb-2015
|
|
gene:Smp_162030
|
6.3.2.12
|
0.971
|
gene:Smp_162030
|
formylTHF biosynthesis I
|
26-Feb-2015
|
|
gene:Smp_162030
|
6.3.2.12
|
0.971
|
gene:Smp_162030
|
formylTHF biosynthesis I
|
26-Feb-2015
|
|
gene:Smp_154950
|
none
|
0.969
|
gene:Smp_154950
|
ceramide degradation
|
26-Feb-2015
|
|
gene:Smp_154950
|
none
|
0.985
|
gene:Smp_154950
|
sphingosine and sphingosine-1-phosphate metabolism
|
26-Feb-2015
|
|
gene:Smp_068250
|
1.3.3.4
|
0.993
|
gene:Smp_068250
|
heme biosynthesis from uroporphyrinogen-III I
|
26-Feb-2015
|
|
gene:Smp_068250
|
1.3.3.4
|
0.993
|
gene:Smp_068250
|
heme biosynthesis from uroporphyrinogen-III I
|
26-Feb-2015
|
|
gene:Smp_164960
|
2.7.1.153
|
0.996
|
gene:Smp_164960
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
gene:Smp_164960
|
2.7.1.153
|
0.996
|
gene:Smp_164960
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
gene:Smp_157710
|
5.4.2.3
|
0.972
|
gene:Smp_157710
|
UDP-N-acetyl-D-glucosamine biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_157710
|
5.4.2.3
|
0.972
|
gene:Smp_157710
|
UDP-N-acetyl-D-glucosamine biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_157100
|
none
|
0.968
|
gene:Smp_157100
|
sphingosine and sphingosine-1-phosphate metabolism
|
26-Feb-2015
|
|
gene:Smp_157100
|
none
|
0.968
|
gene:Smp_157100
|
sphingosine and sphingosine-1-phosphate metabolism
|
26-Feb-2015
|
|
gene:Smp_154470
|
3.1.3.67
|
0.985
|
gene:Smp_154470
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Smp_154470
|
3.1.3.67
|
0.985
|
gene:Smp_154470
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Smp_154470
|
3.1.3.67
|
0.985
|
gene:Smp_154470
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Smp_154470
|
3.1.3.67
|
0.985
|
gene:Smp_154470
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Smp_044970
|
none
|
0.998
|
gene:Smp_044970
|
TCA cycle VII (mammalian)
|
26-Feb-2015
|
|
gene:Smp_147650
|
6.3.4.3
|
0.999
|
gene:Smp_147650
|
folate transformations I,
formylTHF biosynthesis I
|
26-Feb-2015
|
|
gene:Smp_012400
|
3.1.3.-
|
0.967
|
gene:Smp_012400
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Smp_012400
|
3.1.3.-
|
0.967
|
gene:Smp_012400
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Smp_128130
|
2.7.1.137
|
0.998
|
gene:Smp_128130
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
gene:Smp_128130
|
2.7.1.137
|
0.998
|
gene:Smp_128130
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
gene:Smp_081260
|
3.1.3.66
|
0.956
|
gene:Smp_081260
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Smp_081260
|
3.1.3.66
|
0.956
|
gene:Smp_081260
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Smp_159670
|
3.1.3.86
|
0.992
|
gene:Smp_159670
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Smp_159670
|
3.1.3.-
|
0.999
|
gene:Smp_159670
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Smp_210290
|
2.4.1.133
|
0.952
|
gene:Smp_210290
|
glycoaminoglycan-protein linkage region biosynthesis
|
26-Feb-2015
|
|
gene:Smp_210290
|
2.4.1.133
|
0.952
|
gene:Smp_210290
|
glycoaminoglycan-protein linkage region biosynthesis
|
26-Feb-2015
|
|
gene:Smp_145020
|
none
|
0.999
|
gene:Smp_145020
|
L-Ndelta-acetylornithine biosynthesis,
arginine biosynthesis IV
|
26-Feb-2015
|
|
gene:Smp_170690
|
1.5.99.8
|
0.996
|
gene:Smp_170690
|
L-Ndelta-acetylornithine biosynthesis
|
26-Feb-2015
|
|
gene:Smp_170690
|
1.5.99.8
|
0.996
|
gene:Smp_170690
|
L-Ndelta-acetylornithine biosynthesis
|
26-Feb-2015
|
|
gene:Smp_129450
|
3.1.3.9
|
0.971
|
gene:Smp_129450
|
gluconeogenesis III
|
26-Feb-2015
|
|
gene:Smp_129450
|
3.1.3.9
|
0.971
|
gene:Smp_129450
|
gluconeogenesis III
|
26-Feb-2015
|
|
gene:Smp_186670
|
2.1.3.3
|
0.992
|
gene:Smp_186670
|
proline biosynthesis II (from arginine),
arginine biosynthesis IV
|
26-Feb-2015
|
|
gene:Smp_030930
|
none
|
0.996
|
gene:Smp_030930
|
diphthamide biosynthesis
|
26-Feb-2015
|
|
gene:Smp_030930
|
none
|
0.996
|
gene:Smp_030930
|
diphthamide biosynthesis
|
26-Feb-2015
|
|
gene:Smp_194100
|
3.6.1.22
|
1.000
|
gene:Smp_194100
|
NAD salvage pathway II
|
26-Feb-2015
|
|
gene:Smp_060420
|
3.1.3.64
|
0.998
|
gene:Smp_060420
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Smp_060420
|
3.1.3.-
|
0.981
|
gene:Smp_060420
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
gene:Smp_060420
|
3.1.3.64
|
0.998
|
gene:Smp_060420
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Smp_060420
|
3.1.3.-
|
0.981
|
gene:Smp_060420
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
gene:Smp_132740
|
1.14.19.3
|
0.994
|
gene:Smp_132740
|
gamma-linolenate biosynthesis II (animals)
|
26-Feb-2015
|
|
gene:Smp_132740
|
1.14.19.3
|
0.994
|
gene:Smp_132740
|
gamma-linolenate biosynthesis II (animals)
|
26-Feb-2015
|
|
gene:Smp_132640
|
2.7.8.11
|
0.995
|
gene:Smp_132640
|
D-myo-inositol (1,4,5)-trisphosphate biosynthesis,
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
gene:Smp_058690
|
1.11.1.12
|
0.999
|
gene:Smp_058690
|
glutathione redox reactions I
|
26-Feb-2015
|
|
gene:Smp_150660
|
2.7.1.154
|
0.961
|
gene:Smp_150660
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
gene:Smp_136690
|
3.1.1.1
|
0.979
|
gene:Smp_136690
|
retinol biosynthesis
|
26-Feb-2015
|
|
gene:Smp_136690
|
3.1.1.1
|
0.979
|
gene:Smp_136690
|
retinol biosynthesis
|
26-Feb-2015
|
|
gene:Smp_081820
|
1.3.1.93
|
0.997
|
gene:Smp_081820
|
very long chain fatty acid biosynthesis I
|
26-Feb-2015
|
|
gene:Smp_081820
|
1.3.1.93
|
0.997
|
gene:Smp_081820
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_081820
|
1.3.1.93
|
0.997
|
gene:Smp_081820
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_081820
|
1.3.1.93
|
0.997
|
gene:Smp_081820
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_081820
|
1.3.1.93
|
0.997
|
gene:Smp_081820
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_081820
|
1.3.1.93
|
0.997
|
gene:Smp_081820
|
very long chain fatty acid biosynthesis I
|
26-Feb-2015
|
|
gene:Smp_081820
|
1.3.1.93
|
0.997
|
gene:Smp_081820
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_081820
|
1.3.1.93
|
0.997
|
gene:Smp_081820
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_081820
|
1.3.1.93
|
0.997
|
gene:Smp_081820
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_081820
|
1.3.1.93
|
0.997
|
gene:Smp_081820
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_017520
|
3.1.3.57
|
0.987
|
gene:Smp_017520
|
D-myo-inositol (1,4,5)-trisphosphate degradation
|
26-Feb-2015
|
|
gene:Smp_017520
|
3.1.3.57
|
0.987
|
gene:Smp_017520
|
D-myo-inositol (1,4,5)-trisphosphate degradation
|
26-Feb-2015
|
|
gene:Smp_198690
|
2.3.3.10
|
0.946
|
gene:Smp_198690
|
mevalonate pathway I
|
26-Feb-2015
|
|
gene:Smp_198690
|
2.3.3.10
|
0.946
|
gene:Smp_198690
|
mevalonate pathway I
|
26-Feb-2015
|
|
gene:Smp_172660
|
4.1.1.33
|
0.997
|
gene:Smp_172660
|
mevalonate pathway I
|
26-Feb-2015
|
|
gene:Smp_172660
|
4.1.1.33
|
0.997
|
gene:Smp_172660
|
mevalonate pathway I
|
26-Feb-2015
|
|
gene:Smp_212250
|
none
|
0.944
|
gene:Smp_212250
|
tetrahydrobiopterin biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_212250
|
none
|
0.944
|
gene:Smp_212250
|
tetrahydrobiopterin biosynthesis II
|
26-Feb-2015
|
|
gene:Smp_008490
|
2.4.1.186
|
0.996
|
gene:Smp_008490
|
glycogen biosynthesis II (from UDP-D-Glucose)
|
26-Feb-2015
|
|
gene:Smp_008490
|
2.4.1.186
|
0.996
|
gene:Smp_008490
|
glycogen biosynthesis II (from UDP-D-Glucose)
|
26-Feb-2015
|
|
gene:Smp_008490
|
2.4.1.186
|
0.996
|
gene:Smp_008490
|
glycogen biosynthesis II (from UDP-D-Glucose)
|
26-Feb-2015
|
|
gene:Smp_008490
|
2.4.1.186
|
0.996
|
gene:Smp_008490
|
glycogen biosynthesis II (from UDP-D-Glucose)
|
26-Feb-2015
|
|
gene:Smp_013150
|
2.7.7.2
|
0.999
|
gene:Smp_013150
|
flavin biosynthesis IV (mammalian)
|
26-Feb-2015
|