67 of 158 pathway holes were filled (42.4%).
|
Hole-filler
|
Hole EC#
|
P(has-function)
|
All functions of hole-filler
|
Pathway(s) requiring this reaction
|
Date filled
|
|
gene:Tsp_08999
|
2.8.2.30
|
0.966
|
gene:Tsp_08999
|
heparan sulfate biosynthesis (late stages)
|
26-Feb-2015
|
|
gene:Tsp_08999
|
2.8.2.30
|
0.966
|
gene:Tsp_08999
|
heparan sulfate biosynthesis (late stages)
|
26-Feb-2015
|
|
gene:Tsp_04649
|
1.3.8.-
|
0.999
|
gene:Tsp_04649
|
valine degradation I
|
26-Feb-2015
|
|
gene:Tsp_04649
|
1.3.8.-
|
0.999
|
gene:Tsp_04649
|
valine degradation I
|
26-Feb-2015
|
|
gene:Tsp_04772
|
6.3.2.5
|
0.990
|
gene:Tsp_04772
|
coenzyme A biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_04838
|
1.13.11.52
|
0.969
|
gene:Tsp_04838
|
tryptophan degradation XI (mammalian, via kynurenine)
|
26-Feb-2015
|
|
gene:Tsp_04838
|
1.13.11.11
|
0.921
|
gene:Tsp_04838
|
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
|
26-Feb-2015
|
|
gene:Tsp_04838
|
1.13.11.52
|
0.969
|
gene:Tsp_04838
|
tryptophan degradation XI (mammalian, via kynurenine)
|
26-Feb-2015
|
|
gene:Tsp_04838
|
1.13.11.11
|
0.921
|
gene:Tsp_04838
|
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
|
26-Feb-2015
|
|
gene:Tsp_09850
|
2.7.1.154
|
0.997
|
gene:Tsp_09850
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_09850
|
2.7.1.153
|
0.997
|
gene:Tsp_09850
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_09858
|
1.1.1.94
|
0.921
|
gene:Tsp_09858
|
CDP-diacylglycerol biosynthesis I
|
26-Feb-2015
|
|
gene:Tsp_09960
|
3.1.3.9
|
0.993
|
gene:Tsp_09960
|
gluconeogenesis III
|
26-Feb-2015
|
|
gene:Tsp_09960
|
3.1.3.9
|
0.993
|
gene:Tsp_09960
|
gluconeogenesis III
|
26-Feb-2015
|
|
gene:Tsp_09991
|
1.1.1.35
|
1.000
|
gene:Tsp_09991
|
fatty acid beta-oxidation I
|
26-Feb-2015
|
|
gene:Tsp_09991
|
5.1.2.3
|
1.000
|
gene:Tsp_09991
|
fatty acid beta-oxidation I
|
26-Feb-2015
|
|
gene:Tsp_09991
|
5.3.3.8
|
1.000
|
gene:Tsp_09991
|
fatty acid beta-oxidation I
|
26-Feb-2015
|
|
gene:Tsp_12573
|
2.3.1.29
|
0.989
|
gene:Tsp_12573
|
threonine degradation II
|
26-Feb-2015
|
|
gene:Tsp_12573
|
2.3.1.29
|
0.989
|
gene:Tsp_12573
|
threonine degradation II
|
26-Feb-2015
|
|
gene:Tsp_01333
|
none
|
0.920
|
gene:Tsp_01333
|
eumelanin biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_01333
|
none
|
0.921
|
gene:Tsp_01333
|
eumelanin biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_01333
|
none
|
0.920
|
gene:Tsp_01333
|
eumelanin biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_01333
|
none
|
0.921
|
gene:Tsp_01333
|
eumelanin biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_02239.1
|
4.1.1.21
|
0.926
|
gene:Tsp_02239.1
|
inosine-5'-phosphate biosynthesis II
|
26-Feb-2015
|
|
gene:Tsp_02291
|
none
|
0.967
|
gene:Tsp_02291
|
diphthamide biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_02291
|
none
|
0.967
|
gene:Tsp_02291
|
diphthamide biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_06337
|
4.4.1.1
|
0.999
|
gene:Tsp_06337
|
cysteine biosynthesis/homocysteine degradation
|
26-Feb-2015
|
|
gene:Tsp_06337
|
4.4.1.1
|
0.999
|
gene:Tsp_06337
|
cysteine biosynthesis/homocysteine degradation
|
26-Feb-2015
|
|
gene:Tsp_06629
|
2.7.4.2
|
0.921
|
gene:Tsp_06629
|
mevalonate pathway I
|
26-Feb-2015
|
|
gene:Tsp_06629
|
2.7.4.2
|
0.921
|
gene:Tsp_06629
|
mevalonate pathway I
|
26-Feb-2015
|
|
gene:Tsp_02509
|
1.1.1.178
|
0.977
|
gene:Tsp_02509
|
2-methylbutyrate biosynthesis,
isoleucine degradation I
|
26-Feb-2015
|
|
gene:Tsp_02573
|
1.1.1.330
|
0.976
|
gene:Tsp_02573
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Tsp_02573
|
1.1.1.330
|
0.976
|
gene:Tsp_02573
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Tsp_02573
|
1.1.1.330
|
0.976
|
gene:Tsp_02573
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Tsp_02573
|
1.1.1.330
|
0.976
|
gene:Tsp_02573
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Tsp_02573
|
1.1.1.330
|
0.976
|
gene:Tsp_02573
|
very long chain fatty acid biosynthesis I
|
26-Feb-2015
|
|
gene:Tsp_02573
|
1.1.1.330
|
0.976
|
gene:Tsp_02573
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Tsp_02573
|
1.1.1.330
|
0.976
|
gene:Tsp_02573
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Tsp_02573
|
1.1.1.330
|
0.976
|
gene:Tsp_02573
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Tsp_02573
|
1.1.1.330
|
0.976
|
gene:Tsp_02573
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Tsp_02573
|
1.1.1.330
|
0.976
|
gene:Tsp_02573
|
very long chain fatty acid biosynthesis I
|
26-Feb-2015
|
|
gene:Tsp_02737
|
2.8.2.23
|
0.966
|
gene:Tsp_02737
|
heparan sulfate biosynthesis (late stages)
|
26-Feb-2015
|
|
gene:Tsp_02737
|
2.8.2.-
|
0.966
|
gene:Tsp_02737
|
heparan sulfate biosynthesis (late stages)
|
26-Feb-2015
|
|
gene:Tsp_02737
|
2.8.2.23
|
0.966
|
gene:Tsp_02737
|
heparan sulfate biosynthesis (late stages)
|
26-Feb-2015
|
|
gene:Tsp_02737
|
2.8.2.-
|
0.966
|
gene:Tsp_02737
|
heparan sulfate biosynthesis (late stages)
|
26-Feb-2015
|
|
gene:Tsp_03043
|
2.7.7.75
|
1.000
|
gene:Tsp_03043
|
molybdenum cofactor biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_03154
|
none
|
0.990
|
gene:Tsp_03154
|
folate transformations I,
formylTHF biosynthesis I
|
26-Feb-2015
|
|
gene:Tsp_03154
|
1.2.1.-
|
0.999
|
gene:Tsp_03154
|
isoleucine degradation I
|
26-Feb-2015
|
|
gene:Tsp_03154
|
1.2.1.25
|
0.999
|
gene:Tsp_03154
|
valine degradation I
|
26-Feb-2015
|
|
gene:Tsp_03568
|
1.5.1.3
|
1.000
|
gene:Tsp_03568
|
formylTHF biosynthesis I
|
26-Feb-2015
|
|
gene:Tsp_05920
|
2.7.1.150
|
0.994
|
gene:Tsp_05920
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_05910
|
2.8.2.-
|
0.945
|
gene:Tsp_05910
|
heparan sulfate biosynthesis (late stages)
|
26-Feb-2015
|
|
gene:Tsp_05910
|
2.8.2.-
|
0.945
|
gene:Tsp_05910
|
heparan sulfate biosynthesis (late stages)
|
26-Feb-2015
|
|
gene:Tsp_06157
|
5.4.2.3
|
0.928
|
gene:Tsp_06157
|
UDP-N-acetyl-D-glucosamine biosynthesis II
|
26-Feb-2015
|
|
gene:Tsp_06157
|
5.4.2.3
|
0.928
|
gene:Tsp_06157
|
UDP-N-acetyl-D-glucosamine biosynthesis II
|
26-Feb-2015
|
|
gene:Tsp_06799
|
2.8.2.8
|
0.999
|
gene:Tsp_06799
|
heparan sulfate biosynthesis (late stages)
|
26-Feb-2015
|
|
gene:Tsp_06799
|
3.1.1.-
|
0.999
|
gene:Tsp_06799
|
heparan sulfate biosynthesis (late stages)
|
26-Feb-2015
|
|
gene:Tsp_06799
|
2.8.2.8
|
0.999
|
gene:Tsp_06799
|
heparan sulfate biosynthesis (late stages)
|
26-Feb-2015
|
|
gene:Tsp_06799
|
3.1.1.-
|
0.999
|
gene:Tsp_06799
|
heparan sulfate biosynthesis (late stages)
|
26-Feb-2015
|
|
gene:Tsp_06828
|
4.2.1.134
|
0.978
|
gene:Tsp_06828
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Tsp_06828
|
4.2.1.134
|
0.978
|
gene:Tsp_06828
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Tsp_06828
|
4.2.1.134
|
0.978
|
gene:Tsp_06828
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Tsp_06828
|
4.2.1.134
|
0.978
|
gene:Tsp_06828
|
very long chain fatty acid biosynthesis II
|
26-Feb-2015
|
|
gene:Tsp_06828
|
4.2.1.134
|
0.978
|
gene:Tsp_06828
|
very long chain fatty acid biosynthesis I
|
26-Feb-2015
|
|
gene:Tsp_07034
|
2.1.1.114
|
0.986
|
gene:Tsp_07034
|
ubiquinol-10 biosynthesis (eukaryotic)
|
26-Feb-2015
|
|
gene:Tsp_07034
|
2.1.1.114
|
0.986
|
gene:Tsp_07034
|
ubiquinol-9 biosynthesis (eukaryotic)
|
26-Feb-2015
|
|
gene:Tsp_07635
|
3.1.3.67
|
0.976
|
gene:Tsp_07635
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Tsp_07635
|
3.1.3.67
|
0.976
|
gene:Tsp_07635
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Tsp_07635
|
3.1.3.67
|
0.976
|
gene:Tsp_07635
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Tsp_07635
|
3.1.3.67
|
0.976
|
gene:Tsp_07635
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Tsp_07645
|
3.5.1.9
|
1.000
|
gene:Tsp_07645
|
tryptophan degradation XI (mammalian, via kynurenine),
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
|
26-Feb-2015
|
|
gene:Tsp_07704
|
3.1.3.56
|
0.924
|
gene:Tsp_07704
|
D-myo-inositol (1,4,5)-trisphosphate degradation
|
26-Feb-2015
|
|
gene:Tsp_07704
|
3.1.3.86
|
1.000
|
gene:Tsp_07704
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Tsp_07704
|
3.1.3.64
|
0.992
|
gene:Tsp_07704
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Tsp_07704
|
3.1.3.-
|
0.999
|
gene:Tsp_07704
|
3-phosphoinositide degradation
|
26-Feb-2015
|
|
gene:Tsp_07883
|
3.2.1.33
|
0.971
|
gene:Tsp_07883
|
glycogen degradation II
|
26-Feb-2015
|
|
gene:Tsp_07883
|
2.4.1.25
|
0.971
|
gene:Tsp_07883
|
glycogen degradation II
|
26-Feb-2015
|
|
gene:Tsp_07883
|
3.2.1.33
|
0.971
|
gene:Tsp_07883
|
glycogen degradation II
|
26-Feb-2015
|
|
gene:Tsp_07883
|
2.4.1.25
|
0.971
|
gene:Tsp_07883
|
glycogen degradation II
|
26-Feb-2015
|
|
gene:Tsp_07907
|
1.2.1.3
|
0.999
|
gene:Tsp_07907
|
ethanol degradation II
|
26-Feb-2015
|
|
gene:Tsp_07907
|
1.2.1.3
|
0.999
|
gene:Tsp_07907
|
ethanol degradation II
|
26-Feb-2015
|
|
gene:Tsp_11372
|
4.1.1.33
|
0.991
|
gene:Tsp_11372
|
mevalonate pathway I
|
26-Feb-2015
|
|
gene:Tsp_11372
|
4.1.1.33
|
0.991
|
gene:Tsp_11372
|
mevalonate pathway I
|
26-Feb-2015
|
|
gene:Tsp_11409
|
4.1.99.18
|
0.963
|
gene:Tsp_11409
|
molybdenum cofactor biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_11409
|
4.1.99.18
|
0.963
|
gene:Tsp_11409
|
molybdenum cofactor biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_08147
|
none
|
0.999
|
gene:Tsp_08147
|
arginine biosynthesis IV
|
26-Feb-2015
|
|
gene:Tsp_11763.2
|
2.1.2.2
|
0.993
|
gene:Tsp_11763.2
|
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate,
5-aminoimidazole ribonucleotide biosynthesis I
|
26-Feb-2015
|
|
gene:Tsp_00889
|
2.7.1.137
|
0.998
|
gene:Tsp_00889
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_00889
|
2.7.1.137
|
0.998
|
gene:Tsp_00889
|
3-phosphoinositide biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_09781
|
6.3.3.2
|
0.920
|
gene:Tsp_09781
|
folate transformations I,
formylTHF biosynthesis I
|
26-Feb-2015
|
|
gene:Tsp_09781
|
6.3.3.2
|
0.920
|
gene:Tsp_09781
|
folate transformations I,
formylTHF biosynthesis I
|
26-Feb-2015
|
|
gene:Tsp_03785
|
3.1.1.1
|
0.969
|
gene:Tsp_03785
|
retinol biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_03785
|
3.1.1.1
|
0.969
|
gene:Tsp_03785
|
retinol biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_04124
|
2.9.1.2
|
0.997
|
gene:Tsp_04124
|
selenocysteine biosynthesis II (archaea and eukaryotes)
|
26-Feb-2015
|
|
gene:Tsp_04124
|
2.9.1.2
|
0.997
|
gene:Tsp_04124
|
selenocysteine biosynthesis II (archaea and eukaryotes)
|
26-Feb-2015
|
|
gene:Tsp_04388
|
2.8.2.-
|
0.990
|
gene:Tsp_04388
|
heparan sulfate biosynthesis (late stages)
|
26-Feb-2015
|
|
gene:Tsp_04388
|
2.8.2.-
|
0.990
|
gene:Tsp_04388
|
heparan sulfate biosynthesis (late stages)
|
26-Feb-2015
|
|
gene:Tsp_08333
|
1.1.1.300
|
0.910
|
gene:Tsp_08333
|
retinol biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_08333
|
1.1.1.300
|
0.910
|
gene:Tsp_08333
|
retinol biosynthesis
|
26-Feb-2015
|
|
gene:Tsp_08386
|
2.7.1.2
|
0.994
|
gene:Tsp_08386
|
glycogen degradation I
|
26-Feb-2015
|
|
gene:Tsp_08386
|
2.7.1.2
|
0.994
|
gene:Tsp_08386
|
glycogen degradation I
|
26-Feb-2015
|
|
gene:Tsp_08473
|
2.3.1.168
|
0.967
|
gene:Tsp_08473
|
2-oxoisovalerate decarboxylation to isobutanoyl-CoA,
1.2.1.25-RXN
|
26-Feb-2015
|