Predicted Targets of mmu-miR-291a-3p Based on Experimental Evidence
Illumina Probe IDs Gene Symbols Gene Name Entrez ID Log Fold Change upon Dgcr8 Depletion P-value of change upon Dgcr8 Depletion Log Fold Change upon miR-291a-3p Reintroduction P-value of change upon miR-291a-3p Reintroduction GO Terms KEGG Pathways Transcript used for 3'UTR seed counts 6mer(3)-AGCACT 6mer(1A)-CACTTA 6mer(2)-GCACTT 7mer(2)(m8)-AGCACTT 7mer(1A)-GCACTTA 8mer(1A)-AGCACTTA Target Scan Conserved Target Context Score Target Scan Non-conserved Target Context Score miRBase Targets P-value
Nbi0eo.u_ToKS39e_wHp1bp3heterochromatin protein 1, binding protein 3154411.472.9e-210.656.4e-05nucleosome assembly(GO:0006334) OTTMUST00000023193 3 3 3 1 3 1Not Found-0.2342Not Found
HKTHleDlfk2_w4k118Dctn4dynactin 4676651.105.8e-210.921.0e-05 ENSMUST00000025505 1 0 4 1 0 0Not Found-0.208Not Found
xXFXjz.RJjJIk16QSoArhgef18rho/rac guanine nucleotide exchange factor (GEF) 181020981.202.6e-190.561.9e-05actin cytoskeleton organization and biogenesis(GO:0030036) | small GTPase mediated signal transduction(GO:0007264) | regulation of cell shape(GO:0008360) | regulation of Rho protein signal transduction(GO:0035023) OTTMUST00000076126 2 0 2 1 0 0-0.1761Not FoundNot Found
Zsu87Je6Dg9d9Vei1IChic1 * 12212*1.242.2e-180.671.0e-05 OTTMUST00000044104 4 5 5 1 1 0Not Found-0.1875Not Found
3uBv_Ub24UCMUp76E4Tmem87btransmembrane protein 87B724770.671.3e-170.711.2e-05 OTTMUST00000036395 3 0 3 1 0 0Not Found-0.1248Not Found
6SVCgVf5yvkUr3.d5EMgat4amannoside acetylglucosaminyltransferase 4, isoenzyme A2691810.661.6e-170.482.5e-05carbohydrate metabolic process(GO:0005975)N-Glycan biosynthesis(00510) | Glycan structures - biosynthesis 1(01030) Not Found-0.4217Not Found
KFiKoeh3SlfxL7deS8Tbceltubulin folding cofactor E-like2725890.791.4e-150.661.4e-06protein modification process(GO:0006464) ENSMUST00000066148 2 1 3 1 0 0Not FoundNot FoundNot Found
Ej5ewT_J98eO7nrqEoWhsc1l1Wolf-Hirschhorn syndrome candidate 1-like 1 (human)2341350.663.9e-150.543.1e-05transcription(GO:0006350) | regulation of transcription, DNA-dependent(GO:0006355) | chromatin modification(GO:0016568) ENSMUST00000084026 7 2 7 5 2 1Not Found-0.14270.00112896
rKeJNVhH4qQBK_U9ckGnb5guanine nucleotide binding protein (G protein), beta 5146970.547.0e-150.692.1e-06signal transduction(GO:0007165) | G-protein coupled receptor protein signaling pathway(GO:0007186) ENSMUST00000076889 1 0 2 1 0 0-0.1571Not FoundNot Found
BXu_5I6pSBRyHJJf14D030056L22RikRIKEN cDNA D030056L22 gene2259950.629.7e-150.508.7e-06 ENSMUST00000062753 1 0 2 1 0 0Not Found-0.2362Not Found
QXS1Ku6d7erks5LTug 0.733.1e-140.761.3e-05
Holi8e.uF76nVr.e.ETor1btorsin family 1, member B309340.563.9e-140.522.9e-05biological_process(GO:0008150) | chaperone cofactor-dependent protein folding(GO:0051085) OTTMUST00000027995 3 1 2 2 0 0Not Found-0.1008Not Found
oyM1RN1xu0tf7XigesIl7interleukin 7161960.673.0e-120.741.0e-06T cell lineage commitment(GO:0002360) | anti-apoptosis(GO:0006916) | immune response(GO:0006955) | regulation of gene expression(GO:0010468) | positive regulation of B cell proliferation(GO:0030890) | negative regulation of apoptosis(GO:0043066) | negative regulation of catalytic activity(GO:0043086) | bone resorption(GO:0045453) | positive regulation of T cell differentiation(GO:0045582) | positive regulation of organ growth(GO:0046622) | homeostasis of number of cells within a tissue(GO:0048873)Cytokine-cytokine receptor interaction(04060) | Jak-STAT signaling pathway(04630) | Hematopoietic cell lineage(04640) Not Found-0.2369Not Found
Nf_4d307578y3pW6oQBat5HLA-B associated transcript 51937420.654.6e-120.522.8e-06 ENSMUSESTT00000055410 2 1 2 2 1 1Not Found-0.30730.00226352
KeR.j_.XBL3vV15.j8E2f1E2F transcription factor 1135550.735.0e-120.493.2e-05regulation of cell cycle(GO:0051726) | apoptosis(GO:0006915) | transcription(GO:0006350) | regulation of transcription, DNA-dependent(GO:0006355) | cell cycle(GO:0007049) | forebrain development(GO:0030900) | regulation of transcription(GO:0045449) | positive regulation of transcription, DNA-dependent(GO:0045893) | positive regulation of transcription from RNA polymerase II promoter(GO:0045944)Cell cycle(04110) | Pancreatic cancer(05212) | Glioma(05214) | Prostate cancer(05215) | Melanoma(05218) | Bladder cancer(05219) | Chronic myeloid leukemia(05220) | Small cell lung cancer(05222) | Non-small cell lung cancer(05223)OTTMUST00000037809 1 0 2 0 0 0Not FoundNot FoundNot Found
3uKIKTKCuIcniH3tOkBicd2bicaudal D homolog 2 (Drosophila)768950.639.8e-120.492.0e-05microtubule-based movement(GO:0007018) ENSMUST00000048544 1 2 3 1 0 0Not FoundNot FoundNot Found
6YOkcXyoT3LPn3Pv6kPfn2profilin 2186451.006.8e-110.727.1e-05actin cytoskeleton organization and biogenesis(GO:0030036) | cytoskeleton organization and biogenesis(GO:0007010)Regulation of actin cytoskeleton(04810)OTTMUST00000065997 1 0 4 1 0 0-0.1369Not FoundNot Found
QPvVV.Lwb_seLc3E4ICep170centrosomal protein 1705453890.566.0e-100.571.1e-05 ENSMUST00000057037 Not FoundNot FoundNot Found
Nn_v556__f6DXtLhVc 0.431.8e-090.794.2e-06
xT8NPGkl.aPjFXE9.8Entpd7ectonucleoside triphosphate diphosphohydrolase 7936850.583.8e-090.653.5e-06ribonucleoside diphosphate catabolic process(GO:0009191) | ribonucleoside triphosphate catabolic process(GO:0009203)Starch and sucrose metabolism(00500) | Folate biosynthesis(00790)OTTMUST00000065276 1 1 1 1 1 1Not FoundNot FoundNot Found
9o66jF5AB7up_TI4c4Rab11aRAB11a, member RAS oncogene family538690.461.6e-080.524.7e-06transport(GO:0006810) | small GTPase mediated signal transduction(GO:0007264) | protein transport(GO:0015031) -0.3858Not FoundNot Found
QKBEi8HyKHlp5q5K1IIfi35interferon-induced protein 35701100.284.7e-080.392.1e-05 OTTMUST00000005867 1 2 1 1 1 1Not FoundNot FoundNot Found
xekoCDuV.HExea3S_cTnfaip1tumor necrosis factor, alpha-induced protein 1 (endothelial)219270.342.6e-070.906.0e-05potassium ion transport(GO:0006813) | embryonic development(GO:0009790) OTTMUST00000000462 2 0 2 2 0 0-0.2121Not FoundNot Found
o6cIXSzdUskffej_D04933434E20Rik * 99650*0.518.2e-060.651.1e-06 ENSMUST00000068798 2 0 2 1 0 0Not Found-0.2088Not Found
lq_eOfCErKvp0e8E5IZbtb41zinc finger and BTB domain containing 41 homolog2264700.203.3e-050.684.5e-05transcription(GO:0006350) | regulation of transcription, DNA-dependent(GO:0006355) OTTMUST00000051928 4 5 5 3 2 2-0.2492Not FoundNot Found
6X9TfVN8x7_f_OKfqo 0.421.1e-040.386.5e-05
ltnt_R3rt4ml4I9Vq4Cdkn1acyclin-dependent kinase inhibitor 1A (P21)125750.685.0e-040.942.6e-05regulation of cell cycle(GO:0051726) | response to DNA damage stimulus(GO:0006974) | cell cycle(GO:0007049) | cell cycle arrest(GO:0007050) | negative regulation of cell proliferation(GO:0008285) | response to UV(GO:0009411) | positive regulation of B cell proliferation(GO:0030890) | negative regulation of apoptosis(GO:0043066) | positive regulation of non-apoptotic programmed cell death(GO:0043071) | negative regulation of cyclin-dependent protein kinase activity(GO:0045736)ErbB signaling pathway(04012) | Cell cycle(04110) | p53 signaling pathway(04115) | Glioma(05214) | Prostate cancer(05215) | Melanoma(05218) | Bladder cancer(05219) | Chronic myeloid leukemia(05220)OTTMUST00000078425 2 1 3 2 1 1Not Found-0.3089Not Found
ud77jUnSmu2p_f.gcMGtf3c2general transcription factor IIIC, polypeptide 2, beta717520.181.8e-030.585.5e-06transcription(GO:0006350) OTTMUST00000053730 4 1 2 2 1 1Not Found-0.1006Not Found