"spe-13" "[C.elegansII] hc137ts : at 25C, spermatids can activate to form crawling sperm, unable to fertilize. Low hermaphrodite self-fertility at 15C. NA1. [L'Hernault et al. 1988\; SL]" "bli-3" "[C.elegansII]e767 : small irregular shape variable slight blistering in adult. ES2 (adult late larvae) ME1. OA1: n529. [Brenner 1974\; CB]" "spe-8" "[C.elegansII] hc40 : hermaphrodites produce nonfunctional nonmotile sperm with uniformly aberrant pseudopods\; male sperm normal. Self-fertility < 1\% (16C or 25C). ES2 (adult). OA5: hc50. hc53 etc. [L'Hernault et al. 1988\; Shakes and Ward 1989a\; BA]" "mex-3" "[C.elegansII] zu142 : maternal effect lethal mutations which results in the production of excess muscle. The excess muscle is derived from the anterior blastomere AB of the two cell stage embryo. OA8: zu155, zu203, zu205, zu208, zu211, etc. Cloned: encodes novel predicted protein with two KH domains. mRNA accumulates at anterior pole of zygote after fertilization. [JJ]" "sup-34" "[C.elegansII] e2227 : weak amber suppressor, suppresses tra-3(e1107), weakly suppresses unc-52(e669). Anticodon mutation in tRNATrp (rtw-12). NA1. [Kondo et al. 1990]" "mig-1" "[C.elegansII] e1787 : abnormal migration of Q neuroblasts (both QL and QR migrate anteriorly)\; HSN migration also abnormal\; Egl. ES1. OA3: n1354, n1654. [Hedgecock et al. 1987\; Desai et al. 1988\; NJ]" "smg-2" "[C.elegansII] e2008 : adult male has swollen bursa, ES3 ME1. Adult hermaphrodite has protruding vulva ES2. Recessive suppressor of unc-54(r293), tra-2(e1209), etc. unc-54 nonsense RNAs accumulate. OA>10: e2423, ma114, ma122, r863, r920::Tc4,r908 (deletion), etc. Cloned: encodes predicted protein with 36-69\% similarity to yeast UPF1. [Hodgkin et al. 1989\; Pulak and Anderson 1993\; TR]" "spe-15" "[C.elegansII] hc75ts : at 25C, spermatids can activate to form crawling sperm, unable to fertilize. Low hermaphrodite self-fertility at 15C. NA1. [L'Hernault et al. 1988\; SL]" "let-546" "[C.elegansII] h227 : lethal. NA1. [KR]" "let-547" "[C.elegansII] h277 : lethal. NA1. [KR]" "let-572" "[C.elegansII] h220 : lethal. NA1. [KR]" "unc-35" "[C.elegansII] e259 : loopy irregular forward movement, poor backing\; active\; slightly thin. ES2. ME2. NA1. [Brenner 1974]" "egl-30" "[C.elegansII] n686sd : moderate bloating, variable drug response\; Unc slow, very sluggish phenotype, Sma, Gro. Muscle activation defective (flaccid, long).ES3 (adult), ES2 (other stages). ME0 (slight morpho-Mab). OA>10(dominant): n715sd (uncoordinated paralysed phenotype, n715\/+ has Type C bloating), ad805, ad803, ad806, ad809, ad810 (recessive lethal, flaccid arrest at hatching), ad813, ad814. The strongest gf alleles are homozygous lethal. Homozygotes hatch, but are paralyzed, with no or feeble contractions of body wall, pharyngeal, and defecation muscles. However, homozygotes move normally during embryonic elongation. Many alleles are dominant suppressors of eat-11. Also intragenic revertants: n715n1190, n715n1189 (candidate lf: weak Egl, possibly hyperactive), pk45tci. Null phenotype uncertain. Cloned: corresponds to gqa-1, alpha subunit of G protein q (80\% identity to mammalian Gqalpha). [Trent et al. 1983\; Park and Horvitz 1986\; DA\; MT\; PS]" "let-362" "[C.elegansII] h86 : embryonic lethal. OA1: h93. [Howell et al. 1987\; KR]" "dec-12" "[C.elegansII] sa295 : long defecation cycle period, slightly slow growing and scrawny, appears to feed normally [Iwasaki et al. 1995\; JT]" "let-548" "[C.elegansII] h356 : lethal. NA1. [KR]" "mab-20" "[C.elegansII] bx24 : displacements and fusions in rays 1,2,3,4,8,9\; R1,2,4 probably transformed to R3. Variable bulges in posterior body region. OA1: bx61ts (weaker). [Baird et al. 1991\; Chow and Emmons 1994\; EM]" "let-573" "[C.elegansII] h247 : lethal. NA1. [KR]" "let-571" "[C.elegansII] h347 : lethal. NA1. [KR]" "lin-6" "[C.elegansII] e1466 : thin, sterile and uncoordinated after L1\; most postembryonic divisions absent or defective from absence of DNA synthesis\; Q and I divisions normal. No sexual maturation in either sex. ES3 ME0. OA1 (pka let-358). [Sulston and Horvitz 1981\; MT]" "let-549" "[C.elegansII] h193 : lethal. NA1. [KR]" "cib-3" "[C.elegansII] t1008 : Mel?[GE]" "lin-17" "[C.elegansII] n671 : adult hermaphrodite slightly uncoordinated, long, irregularly shaped tail, vulva may be nonfunctional\; many hermaphrodites (50\%) have single small protrusion posterior to vulvas\; some gonadal abnormality and sterility. Abnormally long excretory canals. Diverse asymmetric cell divisions are symmetric or reversed. ES2. Male tail grossly abnormal, may rupture during L2 molt ME0. OA4: n677 (resembles n671), n669 (less penetrant for Muv phenotype), e2257, etc. Cloned: encodes predicted membrane protein(seven TM domains), 28\% identity to Drosophila frizzled. [Sternberg and Horvitz 1988\; Herman et al. 1995\; MT]" "pop-1" "[C.elegansII] zu189mut : maternal effect embryonic lethal,no MS-derived pharyngeal cells\; MS blastomere adopts the fate of sister blastomere E\; resulting embryos have twice the wildtype amount of gut. NA1. Cloned: encodes predicted 487 aa protein with HMG box\; antibody stains nuclei of oocytes, early blastomeres. [Lin et al. 1995\; JJ]" "sup-11" "[C.elegansII] n403sd : dominant suppressor of unc-93(e1500) recessive small scrawny slow growing phenotype. ES3. OA9 (dominant): n401, n402,n404, n406 etc. (all resemble n403). Also alleles derived from n403 e.g. n403n406(recessive suppressor of unc-93(e1500), no phenotype alone). OA7 (recessive). Also putative null alleles derived from n403 e.g. n403n682 (no suppressive effect, recessive lethal, late embryo arrest).OA3: n403n681amb (partly suppressed by sup-5, L1 lethal). [Greenwald and Horvitz 1982\; MT]" "mek-2" "[C.elegansII] n2678 : sterile, vulvaless\; suppresses Muv phenotype of let-60(gf). OA: h294 (pka let-537),n2156 (both similar to n2678), n1859, n1989, n2537 (weaker allele, some fertility), n1859,n1989 (weak alleles, homozygous viable but much early larval lethality, rod-like morphology)\;q425 (pka glv-1, sterile vulvaless adult hermaphrodite, makes sperm but no oocytes, all VPC tertiary), ku114 (viable,suppresses let-60(gf)),etc. Cloned: 55\% identity to human MEK1. [Church et al. 1995\; Kornfeld et al. 1995\; Wu et al. 1995\; EJ\; KR\; MH\; MT]" "let-365" "[C.elegansII] h108 : sterile adult. OA2: h129, h295 (sterile adult). [Howell et al. 1987\; KR]" "let-360" "[C.elegansII] h96 : late larval lethal. NA1. [Howell et al. 1987\; KR]" "ace-2" "[C.elegansII] g72 : class B acetylcholinesterase reduced 98\%\; no behavioral phenotype alone (see ace-1). ES1 ME3. OA11: g73 etc. [Culotti et al. 1981]" "fog-1" "[C.elegansII] e1959sd : homozygous XX animals transformed into fertile females\; homozygous XO animals are somatically male, make oocytes in germ line\; heterozygous XO animals are somatically male with both sperm and oocytes in germline. ES2 (adults). OA>10: e2121, e1959, e2122, q155, q253ts (fertile at 15C). [Barton and Kimble 1990\; Ellis and Kimble 1995\; JK\; RE]" "stu-4" "[C.elegansII] e2406ts : sterile unc, extensive failures of postembryonic cell division at 25C, many polyploid nuclei, probable defect in karyokinesis. Hermaphrodites and males viable and fertile at 15C. [CB]" "let-357" "[C.elegansII] h89 : sterile adult. OA1: h132. [Howell et al. 1987\; KR]" "let-515" "[C.elegansII] h730 : early larval lethal. OA3:h223 (late larval lethal), h139, h149 (both Mel). [KR]" "let-550" "[C.elegansII] h291 : sterile adult. NA1. [KR]" "let-574" "[C.elegansII] h317 : sterile adult. NA1. [KR]" "let-575" "[C.elegansII] h345 : lethal. OA1: h728. [KR]" "let-576" "[C.elegansII] h816 : early larval lethal. OA1: h494. [KR]" "let-577" "[C.elegansII] h503 : early larval lethal. NA1. [KR]" "let-578" "[C.elegansII] h512 : lethal. NA1. [KR]" "let-579" "[C.elegansII] h705 : mid larval lethal. NA1. [KR]" "let-580" "[C.elegansII] h709 : lethal. NA1. [KR]" "let-581" "[C.elegansII] h725 : mid larval lethal. OA1: h876 (similar). [KR]" "let-582" "[C.elegansII] h726 : lethal. NA1. [KR]" "let-583" "[C.elegansII] h738 : early\/mid larval lethal. NA1. [KR]" "let-584" "[C.elegansII] h743 : sterile adult. OA1: h746 (similar). [KR]" "let-586" "[C.elegansII] h846 : mid larval lethal. NA1. [KR]" "let-587" "[C.elegansII] h849 : late larval lethal. NA1. [KR]" "let-368" "[C.elegansII] h121 : early larval lethal. OA1:h826 (sterile adult, not rescued by mating). [Howell et al. 1987\; KR]" "let-372" "[C.elegansII] h126 : sterile adult. NA1. [Howell et al. 1987\; KR]" "let-585" "[C.elegansII] h784 : early larval lethal. NA1. [KR]" "unc-11" "[C.elegansII] e47 : kinker, jerky ratchet-like movement especially in reverse\; slow pharyngeal pumping\; slightly small and thin\; Ric, elevated acetylcholine levels, hypersensitive to levamisole. Some migration defects.ES3 ME2. OA3: e511, e1024 (weaker), h1008Cloned: cosmid rescue (C32E8). Multiple transcripts. [Brenner 1974\; Nguyen et al. 1995\; AL\; NJ\; RM\; TN]" "unc-67" "[C.elegansII] e713 : sluggish, can move well both forward and backward but frequently pauses or jams up. ES2 ME2. NA1. [Brenner 1974\; MQ]" "let-517" "[C.elegansII] h264 : lethal. OA2: h757, h1398. [KR]" "let-518" "[C.elegansII] h316 : embryonic\/early larval lethal. NA1. [KR]" "egl-34" "[C.elegansII] n171 : variable bloating, variable drug response\; some animals WT, some form bag-of-worms (10\%). ES2 (adult). ME0 (variable Mab: blobby rays, misshapen bursa, sex muscle defects). OA1: e1452. [Trent et al. 1983\; CZ\; MT] egl-35III17.53n694ts : transient bloating at 25C\; sensitive to serotonin and to imipramine\; Unc, unhealthy\; precocious HSN differentiation. ES2 (adult 25C). ME3\/ME0(variable Mab: some tail deformity at 25C, less at 20C). NA1. [Trent et al. 1983\; CZ\; MT]" "let-369" "[C.elegansII] h125 : early larval lethal. OA1: h864 (mid larval lethal). [Howell et al. 1987\; KR]" "let-356" "[C.elegansII] h83 : mid-larval lethal. OA3: h501, h679, h871. [Howell and Rose 1990\; KR]" "let-589" "[C.elegansII] h319 : Mel, embryonic arrest. NA1. [KR]" "unc-108" "[C.elegansII] n501dm : sluggish, poor backing. Similar phenotype in n501\/+. ES3. OA1: n777. Possibly haplo-insufficient locus. [Park and Horvitz 1986a]" "let-501" "[C.elegansII] h714 : early larval lethal. OA1: h498 (mid larval lethal). [Howell and Rose 1990\; KR]" "let-509" "[C.elegansII] h867 : leaky late larval lethal\/sterile adult.OA2: h521 (leaky sterile adult), h522. [Howell and Rose 1990\; KR]" "let-510" "[C.elegansII] h740 : lethal. NA1. [Howell and Rose 1990\; KR]" "let-511" "[C.elegansII] h755 : early larval lethal. NA1. [Howell and Rose 1990\; KR]" "unc-73" "[C.elegansII] e936 : coiler, small and dumpyish, inactive\; commissures often on wrong side\; variable defects in axon growth and fasciculation\;occasional lineage defects\; reduced Z migration. Male copulatory spicules short and crumpled. Synergizes with sem-5(n1779) to give Sem migration defect.ES3 ME0. OA>3: rh40, ev454::Tc1,e936je3 (intragenic change, recessive lethal and dominant suppressor of e936). See also sup-39. Cloned: 7.7 and 7.3 kb transcripts, encodes >200 kD protein related to rho-type guanine nucleotide exchange factors, yeast CDC24. [McIntire et al. 1992\; Garriga and Stern 1994\; NJ\; JW\; NW]" "let-373" "[C.elegansII] h234 : early larval lethal. OA2: h70, h573 (early larval lethal). [Howell and Rose 1990\; KR]" "let-366" "[C.elegansII] h112 : mid-larval lethal. OA6: h265 (lethal), etc. [Howell and Rose 1990\; KR]" "fer-7" "[C.elegansII] hc34ts : hermaphrodites and males grown at 25C produce nonfunctional nonmotile sperm. Self-fertility 6\% (25C) 40\% (16C). TSP L4. ES2 (adult). NA1. [Argon and Ward 1980\; BA]" "unc-89" "[C.elegansII] e1460 : good movement, slightly small, thin and transparent\; abnormal reduced birefringence in body wall and pharyngeal muscle\; thick filaments disarranged, no M-line. ES1 ME3. OA>10: st85amb, r291,ad539 (pka phm-1, worms small and starved, feeble pharyngeal contractions), e2338amb,st515::Tc1 etc. Cloned: encodes 750 kD protein related to UNC-22 (twitchin). Antibodies stain middle of A bands. [Waterston et al. 1980\; GB]" "lin-44" "[C.elegansII] n1792 : polarities of B, F, U, T divisions reversed. n1792\/Df similar. Mosaic analysis indicates non-autonomous action. OA1: n2111 (similar). Cloned: encodes member of Wnt family. lin-44:lacZ and lin-44:GFP expressed in tail tip hypodermis. [Herman et al. 1995\; EH\; MT\; SP]" "let-504" "[C.elegansII] h844 : late larval lethal. OA3:h448 (sterile adult), h327, h888 (late larval lethals). [Howell and Rose 1990\; KR]" "let-505" "[C.elegansII] h426 : late larval lethal. NA1. [Howell and Rose 1990\; KR]" "let-353" "[C.elegansII] h46 : mid-larval lethal. NA1. [Howell and Rose 1990\; KR]" "let-506" "[C.elegansII] h300 : late larval lethal. NA1. [Howell and Rose 1990\; KR]" "let-507" "[C.elegansII] h439 : leaky sterile adult. NA1. [Howell and Rose 1990\; KR]" "let-503" "[C.elegansII] h313 : sterile adult. OA1: h418 (similar). [Howell and Rose 1990\; KR]" "let-374" "[C.elegansII] h251 : mid-larval lethal. NA1. [Howell and Rose 1990\; KR]" "unc-74" "[C.elegansII] e883 : weak kinker, slow, slightly small, resistant to 1 mM levamisole, sensitive to hypoosmotic shock\; L1 movement very poor, no backing. ES3 ME2. OA>25: x19 (resembles e883)\; etc. [Lewis et al. 1980\; ZZ]" "anc-1" "[C.elegansII] e1753amb : nuclei of hypodermal cells not elastically anchored\; other cytoskeletal abnormalities\; no gross phenotype. Enhances multivulva phenotype of lin-15 mutants, without change in lineage.e1753\/Df is very unhealthy. ES1. OA4: e1802, e1873, e1874, e1885(all resemble e1753\; all alleles tend to revert spontaneously by intragenic reversion). e1753, e1802, e1873, e1874, e1885 [Hedgecock and Thomson 1982\; CZ]" "let-354" "[C.elegansII] h79 : mid-larval lethal, no dominant effect. OA>20 (recessive lethals), also 3 dominant alleles: ct42, ct76, ct77 (all 3 alleles lead to recessive zygotic larval lethality, dominant embryonic Mel). [Howell and Rose 1990\; Mains et al. 1990\; HR\; KR]" "let-351" "[C.elegansII] h43 : mid-larval lethal. NA1. [Howell et al. 1987\; McKim et al. 1992\; KR]" "let-508" "[C.elegansII] h452 : late larval lethal. OA1: h995. [Howell and Rose 1990\; KR]" "unc-57" "[C.elegansII] e406 : strong kinker, active\; small and thin\; slow pharyngeal pumping\; tends to hypercontract. ES3 ME2. OA>5: e590.e957, e1190, st199, ad592 etc. [Brenner 1974\; Avery 1993\; DA]" "let-613" "[C.elegansII] h198 : lethal. NA1. [KR]" "let-375" "[C.elegansII] h259 : leaky sterile adult. OA1: h391 (similar)[Howell and Rose 1990\; KR]" "let-502" "[C.elegansII] h392 : mid larval lethal. OA5:h783 (late larval lethal), h509 (sterile adult), ca201sd (embryonic arrest, early morphogenesis\; ca201\/+ sometimes abnormal), h732, h835(both mid-larval lethal).All alleles probable dominant negatives. Cloned : encodes protein with similarity to human mytotonic dystrophy kinase. [Howell and Rose 1990\; HR\; JM\; KR]" "unc-38" "[C.elegansII] e264 : weak kinker, sluggish, slightly dumpyish sometimes Egl, resistant to 1mM levamisole in body but not in head\; sensitive to hypoosmotic shock. ES3 ME2. OA>40: e213, e743, x20, etc. Cloned: encodes subunit of nicotinic acetylcholine receptor. [Lewis et al. 1980\; ZZ]" "dyf-1" "[C.elegansII] mn335mut : defective in dye filling (FITC or DiO) of amphid and phasmid neurons. Chemotaxis defective. ME2. [Starich et al. 1995]" "spe-5" "[C.elegansII] hc93 : hermaphrodites and males produce primary spermatocytes that occasionally begin first meiotic division but do not differentiate further\; abnormal fibrous body-membranous organelle complex. Self-fertility <1\%. ES2 (adult). OA3: hc110, etc., all slightly leaky, cs. Cloned: encodes predicted 25 kD protein, 4 TM domains, large hydrophilic domain. [L'Hernault et al. 1988\; SL]" "pat-10" "[C.elegansII] NMK. Encodes predicted 161 aa protein,3 calcium-binding domains\; closest similarity to vertebrate cardiac troponin C\; see pat-10.tnc-1:lacZ expressed in body wall muscle. [HK]" "pat-10" "[C.elegansII] st568 : severe Pat phenotype\; some pharyngeal pumping. OA1: st575. Probably corresponds to tnc-1, encoding troponin C. [Williams and Waterston 1994\; HK\; RW]" "emb-6" "[C.elegansII] hc65ts,mm : at 25C 14 cell arrest, no gut granule birefringence\; division rates very slow. Normal and defective execution before first cleavage. Viable at 16C. OA1: g36ts (similar). [Miwa et al. 1980\; Denich et al. 1984\; MJ]" "mes-3" "[C.elegansII] bn35 : grandchildless, progeny undergo normal embryogenesis but develop into agametic adults\; few germ cells made. Normal P granule staining. XO germ line less affected. OA4: bn53 (stronger allele), bn21ts (100\% sterile 25C, 2\% 16C\; T-shift suggests action in early embryo). Cloned: 3.1 kb transcript, encodes novel protein. In operon with dom-3. [Capowski et al. 1991\; SS]" "let-598" "[C.elegansII] h213 : lethal. OA1: h813. [KR]" "let-519" "[C.elegansII] h405 : lethal. NA1. [KR]" "cib-1" "[C.elegansII] e2300ts : maternal effect embryonic lethal at25C, WT at 15C. TSP in oocyte, early embryo. Mutant embryos exhibit abnormal delayed cleavage of P1, P2, P3\; other pleiotropic defects. OA6: e2303 (non-conditional strict Mel), e2301,e2302, e2304, e2305, e2306 (all ts, weaker than e2300). [Schnabel and Schnabel, 1990]" "him-1" "[C.elegansII] e879sd : self-progeny 21\% XO male, 5\% 3X herm\; 8\% ova are nullo-X as a result of reductional meiotic nondisjunction\; X chromosome recombination specifically reduced 40\% or more, except at left end (recombination increased)\; Rad.e879\/+ self-progeny 1\% XO. ES3 (progeny). ME2. NA1. [Hodgkin et al. 1979\; Broverman and Meneely 1994]" "unc-63" "[C.elegansII] e214 : weak kinker, slow, inactive, resistant to 1 mM levamisole, sensitive to hypoosmotic shock\; elevated acetylcholine levels. ES3 ME2. OA>50: x13 (pka lev-7, Lev,Ric, poor backing\; ES3 ME3), x18, x37 etc. (most alleles resemble e214). Also rare exceptional alleles: x26 (almost normal movement, slight levamisole resistance), b404 (Ric, trichlorfon resistant, slight Lev, slight Unc), x33 (more resistant in body than in head). Previous reference allele \"e384\" is double with unc-11. [Lewis et al. 1980\; Nguyen et al. 1995\; AL\; RM\; TN\; ZZ]" "let-364" "[C.elegansII] h104 : sterile adult. NA1. [Howell et al. 1987\; KR]" "let-359" "[C.elegansII] h94 : sterile adult. NA1. [Howell et al. 1987\; KR]" "let-361" "[C.elegansII] h97 : late larval\/early adult lethal. OA3: h113, h116, h323gri. [Howell et al. 1987\; KR]" "let-363" "[C.elegansII] h98 : late larval lethal. OA4: h111 (early adult arrest), h60, h114, h131 (lethal). [Howell et al. 1987\; KR]" "sem-2" "[C.elegansII] n1343mut : Egl, hermaphrodite sex muscles adopt body wallmuscle fate.ME3. OA5: some alleles have additional phenotypes ,4 are embryonic lethal, arrest 1.5-fold with bloated head. [MT\; NH\; RW]" "let-371" "[C.elegansII] h123 : mid- to late larval lethal\/sterile adult. NA1. [Howell et al. 1987\; KR]" "let-352" "[C.elegansII] h45 : late larval lethal\/sterile adult. NA1. [Howell et al. 1987\; KR]" "let-599" "[C.elegansII] h290 : sterile adult. NA1. [KR]" "spe-11" "[C.elegansII] hc77ts : hermaphrodites and males grown at 25C produce motile sperm that are fertilize oocytes leading to abnormal early development.defective. Self-fertility 3\% (25C) 100\% (16C). Similar phenotype in hc77\/Df. ES2 (adult). OA3: hc90 (nonconditional sterile). Cloned: encodes 299 aa novel protein, highly charged and hydrophilic\; transcript only in sperm, but forced expression in oocyte can rescue Spe phenotype. SPE-11 in perinuclear halo of mature sperm. [Hill et al. 1989\; SS]" "let-595" "[C.elegansII] h353 : lethal. OA1: h372. [KR]" "let-370" "[C.elegansII] h128 : sterile adult or Mel with larval lethality. OA1: h210. [Howell et al. 1987\; KR]" "dpy-5" "[C.elegansII] e61 : strong dumpy\; early larvae non-dumpy\; e61\/+ is very slightly dumpy\; homozygote suppressed by Smg, e61\/+ enhanced by Smg. ES3 ME1. OA7: e565, e907pdi, s102, s111fdi, s1300::Tc1, s1706spo. Cloned: encodes novel protein, 257aa, has signal sequence. [Brenner 1974\; Hodgkin et al. 1989\; KR]" "let-355" "[C.elegansII] h81 : sterile adult. NA1. [Howell et al. 1987\; KR]" "let-393" "[C.elegansII] h225 : early larval lethal. OA1: h375 etc. Cloned: cosmid rescue (F40D12)." "let-367" "[C.elegansII] h119 : sterile adult. NA1. Cloned: cosmid rescue (C12H4). [Howell et al. 1987\; KR]" "cod-7" "[C.elegansII] sy190 : males unable to insert spicules during mating. [PS]" "sup-40" "[C.elegansII] lb130 : dominant suppressor of unc-8(e15), unc-8(n491). Also recessive phenotypes, independent of unc-8 genotype: slow growth, sterility (abnormal oocytes), swollen hypodermal nuclei in adult, resistant to NDG (nordihydroguiaretic acid). [Shreffler et al. 1995\; MP]" "let-530" "[C.elegansII] h798 : early larval lethal. OA5: h359, etc. Cloned: partial cosmid rescue (M01A12)of h798, to Mel (cleavage arrest). [KR]" "let-395" "[C.elegansII] h271 : sterile adult, undeveloped gonad. NA1. Cloned: partial cosmid rescue (M01A12),to Mel with arrest at cleavage stage. [KR]" "let-376" "[C.elegansII] h130 : early larval lethal. OA6: h416 (lethal), etc. Cloned: cosmid rescue (M01A12) [Howell et al. 1987\; KR]" "let-378" "[C.elegansII] h124 : sterile adult. OA3: h181, h401, h563. Cloned: cosmid rescue (C07F10)[Howell et al. 1987\; KR]" "let-377" "[C.elegansII] h110 : early larval lethal. OA2: h443, h766[Howell et al. 1987\; KR]" "let-379" "[C.elegansII] h127 : embryonic or early larval lethal. OA2: h186, h712. [Howell et al. 1987\; KR]" "unc-40" "[C.elegansII] e271 : weak kinker, dumpyish, slow but fairly active\; Egl\; variable defects in VD and DD commissures\; general failure in ventralward migrations. ES2 ME0. OA>5: e1430 (pka unc-91, e1478,n324, n473, ev457 (probable null), etc. Cloned: encodes predicted large protein with TM domain,extracellular fibronectin and Ig domains\; related to chicken neogenin, human tumor suppressor DCC. unc-40:GFP expressed in cells undergoing circumferential migrations or extensions. [Hedgecock et al. 1990\; NW]" "let-531" "[C.elegansII] h733 : late larval lethal. OA1: h767. [KR]" "mab-2" "[C.elegansII] e1241 : adult male has 6-18 missing copulatory rays as a result of variable failures of V and T lineages\; bursa often grossly distorted. ME0\/ME1. Hermaphrodite gross phenotype normal\; late hypodermal V and T divisions variably defective. ES1 (hermaphrodite) ES3 (adult male). NA1. [Hodgkin 1983a\; Link et al. 1988\; CB]" "let-532" "[C.elegansII] h715 : embryonic lethal. NA1. Cloned: cosmid rescue (anomalous?). [KR]" "pat-11" "[C.elegansII] st541 : mild Pat phenotype\; paralysed pharyngeal muscles. [Williams and Waterston 1994\; RW]" "lin-35" "[C.elegansII] n745 : almost WT alone (reduced fertility)\; Muv (extra vulval differentiation) in homozygotes with lin-8, lin-38 or lin-15(n767). ES2. OA1: n373 (similar). [Ferguson and Horvitz 1989\; MT\; PS]" "let-388" "[C.elegansII] h88 : early larval lethal. OA2: h729, h843. [Howell et al. 1987\; KR]" "let-514" "[C.elegansII] h753 : early\/mid larval lethal. NA1. Cloned: partial cosmid rescue (C32E7),to sterile adult, no oocytes. [KR]" "air-2" "[C.elegansII] h289 : sterile adult (gonad tumorous mass). OA3: h408, h437, h812 (sterile adults). Cloned: partial cosmid rescue (C32E7)\; rescued to Mel. [KR]" "rad-8" "[C.elegansII] mn163 : hypersensitive to UV not to X irradiation or MMS. Reduced brood size (7\% of wildtype), young hermaphrodites lay many inviable eggs. Hypersensitive to paraquat, high oxygen concentration (lethal at 60\%) (see also mev)\; increased lifespan at 16C.ES1 ME0. NA1. [Hartman and Herman 1982\; Ishii et al. 1994\; TJ\; TK\; PH]" "mev-3" "[C.elegansII] kn3 : increased paraquat sensitivity, hypersensitive to oxygen. [TK\; TM]" "let-512" "[C.elegansII] h797 : Mid-larval lethal. OA5: h351, etc. [KR]" "let-513" "[C.elegansII] h752 : sterile adult. NA1. [KR]" "let-384" "[C.elegansII] h84 : late larval lethal or sterile adult. OA3: h388, h454, h865. [Howell et al. 1987\; KR]" "unc-94" "[C.elegansII] su177 : slow, especially in adult\; abnormal patchy muscle birefringence and ultrastructure\; collections of thin and `intermediate' filaments (no staining with anti-intermediate filament antibodies). ES2 ME2. NA1. [Zengel and Epstein 1980\; HE]" "mal-3" "[C.elegansII] qm34 : head frequently deformed because buccal opening displaced ventrally, dorsally or laterally\; some embryonic lethality, very high larval lethality\; full zygotic and maternal rescue. NA1. [MQ]" "let-391" "[C.elegansII] h91 : late larval lethal or sterile adult. OA3:h823 (early\/mid larval lethal), h736, h475. [Howell et al. 1987\; KR]" "let-602" "[C.elegansII] h283 : early larval lethal. OA2: h374, h497. Cloned: mixed cosmid rescue, (incl. C46H8),partial rescue to sterile adult, no oocytes. [KR][McDowall JS]" "let-396" "[C.elegansII] h217 : early larval lethal. OA4: h354 etc. [KR]" "let-611" "[C.elegansII] h850 : early\/mid larval lethal. OA2. Cloned: mixed cosmid rescue (incl. C48E7),rescue to sterile adult, no oocytes. [KR]" "let-381" "[C.elegansII] h107 : embryonic or early larval lethal. OA2: h495, h747. Cloned (cosmid F26B1). [Howell et al. 1987\; KR]" "bli-4" "[C.elegansII] e937 : adult blistered, especially head\; penetrance 90\%\; unique Class I allele. ES3 (old adult) ME1. OA13: all other alleles result in late embryonic lethality, most are class II, fail to complemente937. e.g. h42, h199, h254, h1403. Also s90(pka let-77, class III allele, late larval lethal,complements e937 but not other alleles)Cloned: multiple alternatively spliced transcripts, encoding predicted endoproteases (KEX2\/subtilisin class) with different C-termini,[Peters et al. 1991, Thacker et al. 1995, KR]" "let-387" "[C.elegansII] h87 : mid- to late larval lethal. OA1: h183. [Howell et al. 1987\; KR]" "let-380" "[C.elegansII] h80 : late larval lethal. OA2: h675, h831. [Howell et al. 1987\; KR]" "gld-2" "[C.elegansII] h292 : sterile adult. NA1[KR]" "gld-2" "[C.elegansII] q497 : germ cells enter meiosis, fail in pachytene, make enlarged oocyte-like cells. Spermatogenesis also defective in males. In presence of extragenic modifier (q525), proximal germ line becomes mitotic. NA1. [JK]" "evl-10" "[C.elegansII] ar95 : everted vulva, sterile\; abnormal L4 vulval invagination\; abnormal uterus\; distal germ line abnormal\; no sperm or oocytes. NA1. [Seydoux et al., 1993]" "let-601" "[C.elegansII] h281 : embryonic lethal. NA1. Cloned: cosmid rescue (ZC338). [KR]" "let-608" "[C.elegansII] h706 : early larval arrest, lives 1-2 weeks. OA2. [KR]" "let-610" "[C.elegansII] h695 : sterile adult. NA1. [KR]" "let-386" "[C.elegansII] h117 : mid-larval lethal. OA4: h678, etc. [Howell et al. 1987\; KR]" "let-604" "[C.elegansII] h293 : sterile adult. OA1: h490 (similar). [KR]" "let-382" "[C.elegansII] h82 : mid-larval lethal. OA1: h476. [Howell et al. 1987\; KR]" "let-390" "[C.elegansII] h44 : late larval lethal or sterile adult. NA1. [Howell et al. 1987\; KR]" "let-607" "[C.elegansII] h402 : embryonic lethal. NA1. [KR]" "mei-2" "[C.elegansII] ct102 : Mel, embryonic arrest as mass of cells without morphogenesis\; abnormal oocyte meiosis\; dominant suppressor of mei-1(dm), mel-26(dm).OA1: ct98 (dominant suppressor of mei-1(dm), slight recessive Mel, weak Him, viable). [Mains et al. 1990\; HR]" "let-383" "[C.elegansII] h115 : early to mid-larval lethal. OA3: h389, h527, h727. [Howell et al. 1987\; [McKim et al. 1992\; KR]" "let-392" "[C.elegansII] h120 : early larval lethal. OA8: h122 etc. [Howell et al. 1987\; McKim et al. 1992\; KR]" "let-397" "[C.elegansII] h228 : early larval lethal. OA2: h221, h445. [McKim et al. 1992\; KR]" "let-544" "[C.elegansII] h692 : sterile adult. NA1. [McKim et al. 1992\; KR]" "smg-5" "[C.elegansII] r860 : adult male has swollen bursa, adult hermaphrodite has protruding vulva. ME1. Recessive suppressor of unc-54(r293), tra-2(e1209), etc. unc-54 nonsense RNAs accumulate.OA1: r919::Tc1. Cloned: encodes 549 aa novel protein\; 56 kD protein detected by western. In vitro and in vivo, SMG-5 interacts with SMG-7. [Hodgkin et al. 1989\; Pulak and Anderson 1993\; TR]" "let-605" "[C.elegansII] h312 : sterile Unc adult. h312\/Df sterile, Evl, strong coiler Unc. OA4 (all alleles Unc). [McKim et al. 1992\; KR]" "unc-37" "[C.elegansII] e262 : weak coiler, fairly active\; phenotype similar to Unc-4. ES2 ME1. OA2 (recessive): s80 (pka let-76, L1 lethal), h763 (Unc, adult sterile). Also dominant suppressors of unc-4(e2322ts):wd14, wd16, wd17, wd18 (no phenotype alone, allele-specific dominant suppressors of e2322). Intragenic revertants, e.g. wd17wd19, resembl eh763. Cloned: encodes predicted 614 aa protein with similarity to groucho-related transcription factors, 6 WD40 repeats in C-term. [Miller et al. 1993\; NC]" "unc-87" "[C.elegansII] e1216 : limp paralysed or very sluggish\; somewhat Egl\; larvae more paralysed\; abnormal body muscle birefringence and ultrastructure, thin filaments in small bundles. ES3 ME0. OA>10: e1459amb (phenotype more severe than e1216), st39 r320 etc. Cloned: encodes predicted 40 kD protein with similarities to vertebrate smooth muscle proteins calponin, Drosophila mp20\; localized to I bands. Alternative splicing. [Waterston et al. 1980\; Goetinck and Waterston 1994\;RW]" "let-398" "[C.elegansII] h257 : arrests L2. NA1. Cloned: partial cosmid rescue (K01B11)[McKim et al. 1992\; KR]" "let-529" "[C.elegansII] h238 : early larval lethal. OA3. [McKim et al. 1992\; KR]" "let-399" "[C.elegansII] h273 : L4 lethal. NA1. [McKim et al. 1992\; KR]" "let-521" "[C.elegansII] h704 : L4 lethal. NA1. [McKim et al. 1992\; KR]" "let-385" "[C.elegansII] h85 : early larval lethal. Highly mutable:OA>15: h578 (spontaneous, late larval lethal),h940, etc. [Howell et al. 1987\; McKim et al. 1992\; KR]" "let-543" "[C.elegansII] h792 : L4 lethal. NA1. [McKim et al. 1992\; KR]" "let-534" "[C.elegansII] h260 : mid larval lethal, coiler Unc. OA1: h196 (mid larval lethal). Cloned: cosmid rescue (T14D10). [McKim et al. 1992\; KR]" "dpy-14" "[C.elegansII] e188ts : medium dumpy adult, strong dumpy L1 (20C)\; ts lethal (25C). Lethality enhanced bySmg. ES3 (all stages 20C). Synthetic lethal with some mutations at 20C. ME2. OA2: n497, s70. Cloned: cosmid rescue. [Brenner 1974\; McKim et al. 1992\; KR\; TR]" "let-394" "[C.elegansII] h262 : early to mid-larval lethal. OA6:h361 (sterile adult), etc. Cloned: cosmid rescue (T14D10). [McKim et al. 1992\; KR]" "let-528" "[C.elegansII] h1012 : late larval lethal. OA1: h58spo (similar). [McKim et al. 1992\; KR]" "mec-6" "[C.elegansII] e1342 : touch insensitive, lethargic. Suppresses Deg phenotype of mec-4(dm),deg-1(dm), deg-2(dm).ES2 ME3. OA>10: e1609spo, u247ts (may be Mec only in head), e1472, u450, etc. [Chalfie and Au 1989\; Huang and Chalfie 1994\; MP\; TU\; ZB]" "let-545" "[C.elegansII] h842 : sterile adult, very few germ line nuclei, no oocytes or sperm. NA1. Cloned: cosmid rescue (T21G5). Possibly = glh-1. [McKim et al. 1992\; KR]" "che-1" "[C.elegansII] e1034 : non-chemotactic to sodium ion\; abnormal sensory neuroanatomy especially AFD, IL2 cells. ES1 ME2. OA>5: e1035, p674 (pka tax-1, normal thermotaxis, poor osmotic avoidance), p679, p680, p692, p696. [Dusenbery 1976\; Lewis and Hodgkin 1977]" "rad-3" "[C.elegansII] mn157 : extremely hypersensitive to UV, not to X irradiation\; hypersensitive to chronic MMS treatment (L1 arrest in 0.1 mM)\; reduced brood size (58\% of wildtype)\; reduced photoproduct excision\; not hypersensitive to UV-psoralen. ES1 ME3. [Hartman et al. 1989\; Hartman and Marshall 1992\; PH]" "smg-1" "[C.elegansII] e1228 : adult male has swollen bursa.ES3 (adult male) ME1. Adult hermaphrodite has protruding vulva. ES2. Recessive suppressor of unc-54(r293), tra-2(e1209), etc. unc-54 nonsense RNAs accumulate.OA>10: e1233, e2134spo (similar phenotypes), ma127, ma131, r861, r913spo, etc. Cloned: 7.8 kb transcript, encodes predicted protein with some kinase similarity in C-term. [Hodgkin et al. 1989\; Pulak and Anderson 1993\; TR]" "dyf-10" "[C.elegansII] e1383 : defective in dye (FITC or DiO) filling of amphid and phasmid neurons. Chemotaxis defective. ME4. NA1. [Starich et al. 1995]" "let-86" "[C.elegansII] s141 : L1 lethal. NA1. [McKim et al. 1992\; KR]" "let-389" "[C.elegansII] h680 : early larval lethal. OA10: h428, h106 (both early larval lethal), h698 (late larval lethal). Complex complementation, h698\/h428 is fertile. [Howell et al. 1987\; McKim et al. 1992\; KR]" "let-400" "[C.elegansII] h269 : early to mid-larval lethal. OA5: h878, h590gri, etc. [McKim et al. 1992\; KR]" "let-520" "[C.elegansII] h690 : L4 lethal. OA1: h1003 (similar). [McKim et al. 1992\; KR]" "sem-4" "[C.elegansII] n1378 : Egl, hermaphrodite sex muscles fail to differentiate\; additional axon and lineage defects. ME0 (severe Mab), HME3. OA3: h769, n2087, n1971 (stronger allele, two mesodermal and six neuronal cell types pleiotropically affected\; 2 additional touch cells formed in tail), etc. Cloned: encodes predicted protein with 6 C2H2 zincfinger motifs. [Desai et al. 1988\; Mitani et al. 1993\; MT\; NH\; TU]" "emb-14" "[C.elegansII] g43ts,nm : osmotically sensitive eggs at 25C 100\% eggs arrest during proliferation. Escapers arrest as larvae\; L1 temperature shift-up results in some gonad abnormality. At 16C viable poor male mating. OA1: g14ts,mm? (similar phenotypes, lower penetrance). [Cassada et al. 1981\; RC]" "let-522" "[C.elegansII] h735 : early larval lethal. OA2: h240, h519. [McKim et al. 1992\; KR]" "let-523" "[C.elegansII] h751 : early larval lethal. OA1: h479. [McKim et al. 1992\; KR]" "let-525" "[C.elegansII] h874 : mid larval lethal. OA1: h410[McKim et al. 1992\; KR]" "emb-10" "[C.elegansII] hc63ts : embryonic arrest.OA1: k12ts (sterile\; viable at 16C). [MJ]" "unc-14" "[C.elegansII] e57 : very sluggish, almost paralysed\; small and dumpyish tends to coil\; some egg retention\; PVP defects.ES3 ME0. OA>5: e157 (multiple aspects of axon outgrowth affected\; nerve processes contain large abnormal varicosities),e608, e866, e1119, etc. Cloned: cosmid rescue (R05H7). [Brenner 1974\; McIntire et al. 1992\; FK\; MQ\; MT\; NJ]" "eat-15" "[C.elegansII] ad602 : medium to weak Eat: slippery isthmus, corpus, and grinder. NA1. [Avery 1993\; DA]" "hlh-2" "[C.elegansII] NMK. Encodes homolog of vertebrate E12, Drosophila daughterless. lacZ fusion indicates transcription in some neuronal precursors. Antibody staining indicates all blastomere nuclei stain up to 200-cell stage, later expression complex, strong in head, ventral cord and tail at comma stage\; fewer than 20 cells stain at hatching. Cosmid K07G5. [KM]" "let-527" "[C.elegansII] h207 : early larval lethal. OA3: h209 (mid larval lethal), h357 (some maternalrescue to Spe adult), h932(early larval lethal). [McKim et al. 1992\; KR]" "let-539" "[C.elegansII] h938 : mid larval lethal. NA1. [McKim et al. 1992\; KR]" "let-75" "[C.elegansII] s101 : early larval lethal (L1). No pumping, pharyngeal birefringence abnormal\; possibly = myo-1. OA3: s107, s108, s143. [McKim et al 1992\; Avery 1993\; DA\; KR\; RW]" "zyg-2" "[C.elegansII] b10ts,mm : L4 shift-up results in embryonic arrest at <25-50 nuclei, early cleavage slow\; TSP before fertilization. L1 shift-up results in abnormal gonadogenesis, male sterility. Viable at 16C\; male fertility low at 16C. OA1: g57. [Wood et al. 1980\; Denich et al. 1984]" "let-524" "[C.elegansII] h442 : early larval lethal. OA4: h53gri, etc. [McKim et al. 1992\; KR]" "sog-1" "[C.elegansII] q305 : recessive suppressor of ts glp-1 alleles q224 and q231, suppresses both germ-line and embryonic defects. Does not suppress stronger glp-1 alleles. No phenotype alone. Other alleles exhibit complex non-allelic non-complementation with mutations of other sog genes. OA1: q298 [Maine and Kimble 1993\; EL]" "let-542" "[C.elegansII] h986 : early larval lethal. NA1. [McKim et al. 1992\; KR]" "unc-15" "[C.elegansII] e73 : limp paralysed phenotype, larvae move slightly better\; Egl\; disorganized muscle structure\; suppressed by sup-3\; e73\/+ slightly slow. ES3 ME0. OA>10: e1214amb (more severe phenotype than e73, not suppressed by sup-3), e1402ts (moves well at 15C, paralysed at 25C), ut37 (lethal embryonic arrest at 4-fold stage), r404, r408, m81, s40, su228 etc. Cloned: encodes 886 aa paramyosin. Extensive structural analysis. [Kagawa et al. 1989\; Gengyo-Ando and Kagawa 1991\; Epstein et al. 1993\; HE\; HK]" "let-540" "[C.elegansII] h884 : late larval lethal. NA1. [McKim et al. 1992\; KR]" "unc-13" "[C.elegansII] e51 : paralysed, kinky, small, irregular pharyngeal pumping\; able to lay eggs. Ric, high acetylcholine levels\; variable neuroanatomical defects.ES3 ME0. OA>30: e450amb, e312amb (non-null),e309 (suppressed by sup-6), s69, s178 etc. All alleles similar to e51 or slightly weaker. Cloned: very large gene, encodes 1734 aa novel protein with contains phorbol ester (diacylglycerol) binding site. Antibodies detect 190 kD UNC-13. [Brenner 1974\; Ahmed et al. 1992\; Nguyen et al. 1995]" "spe-4" "[C.elegansII] hc78 : hermaphrodites and males produce primary spermatocytes that contain 4 haploid nuclei\; males retain these spermatocytes while hermaphrodites resorb them when oogenesis begins. Self-fertility 0\%. Similar phenotype in hc78\/Df. Fibrous body-membranous organelle formation disrupted.ES2 (adult). OA2: hc81, q347 (deletion null). Cloned: 1.3 kb transcript, spermatogenesis specific\; encodes predicted 465 aa protein, probable 7 TM domains, similarity to human S182(Alzheimer's associated) and SEL-12. SPE-4 segregates to spermatids. [L'Hernault and Arduengo 1992\; SL]" "goa-1" "[C.elegansII] sy192 : hyperactive, Egl-c, defective male mating OA3: pk39 (Tc1 insertion, similar phenotypes),n363, n1134 (some axon guidance defects ?) Cloned: encodes homolog of mammalian G protein alpha subunit (>80\% identity). goa-1:lacZ expressed in most neurons,some muscle cells, pharynx, distal tip cells. Transgene overexpression leads to lethargy,slow pumping, egg-laying defects, irregular defecation. [Mendel et al. 1995\; Segalat et al. 1995\; KP\; PS]" "ego-1" "[C.elegansII] om18 : recessive enhancer of glp-1(bn18) at 20C\; has reduced germ cell number, 50\% of wild type in young adult, delayed spermatogenesis, abnormal unfertilized oocytes. NA1. [Qiao et al. 1995\; EL]" "emb-12" "[C.elegansII] g5ts,mm : osmotically sensitive eggs at 25.6C (leaky at 25C), 72\% arrest during early proliferation\; escapers have abnormal gonads. Temperature shift-up in L1 results in incompletely penetrant gonad defects. Viable at 16C. NA1. [Cassada et al. 1981\; RC]" "emb-19" "[C.elegansII] g22ts,mm : osmotically sensitive eggs at 25C, 100\% arrest during early proliferation. Escapers arrest L1-L4. L1 temperature shift-up affects gonadogenesis. At 16C viable. NA1. [Cassada et al. 1981\; RC]" "let-87" "[C.elegansII] s106 : semi-viable, L1 lethal with dpy-14(e188). OA2: s87 (L1 lethal), s139. [McKim et al. 1992\; KR]" "aex-1" "[C.elegansII] sa9: defecation defective, severely constipated, anterior body contraction (aBoc) and expulsion muscle contraction (Exp) steps of defecation nearly always missing, adult males not constipated and mate well. OA3: sa10, sa27 (weaker), sa49 (weaker)[Thomas 1990: JT]" "let-81" "[C.elegansII] s88 : L1 lethal. NA1. [Rose and Baillie 1980\; KR]" "let-82" "[C.elegansII] s85 : L1 lethal (larva abnormal?). NA1. [Rose and Baillie 1980\; KR]" "let-85" "[C.elegansII] s142 : L1 lethal. NA1. [McKim et al. 1992\; KR]" "let-88" "[C.elegansII] s132 : L1 lethal. NA1. [McKim et al. 1992\; KR]" "let-90" "[C.elegansII] s140 : L1 lethal (larva abnormal?). NA1. [McKim et al. 1992\; KR]" "gld-1" "[C.elegansII] q485 : hermaphrodite germ cells enter meiosis, fail in pachytene, re-enter mitosis and form large proximal germline tumor\; males unaffected. Probable null phenotype. ES3 (adult), ME3.OA>15: multiple phenotypic classes and subclasses, class A: q268, q365 (probable nulls, resemble q485)\; class B: q93oz12 (sperm, then germ cells arrested in pachytene)\;class C: q93 (gf, Mog)\; class D: q126 (gf, Fog)\; class E: q266 (gf, Fog, abnormal oocytes)\; class F: q343 (sperm, then abnormal oocytes). Complex complementation. Cloned: encodes predicted 463 or 466 aa proteins,with similarity to shrimp GRP33, mouse Src-associated protein Sam68\; includes KH (possible RNA binding) domain. [Francis et al. 1995 \; Jones and Schedl 1995\; BS]" "eat-11" "[C.elegansII] ad541 : weak Eat: slippery corpus. Slightly long. Movement slightly loopy (i.e. bends are deeper than normal). Hypersensitive to arecoline (cholinergic agonist): will not grown at concentrations >= 1 mM. Synthetic lethal with eat-6\; suppressed by egl-30(gf), exp-2(gf). NA1. [Avery 1993\; DA\; JT]" "unc-55" "[C.elegansII] e402 : slow, very poor backing, tends to coil ventrally\; healthy\; abnormal VD neurons (adopt DD synaptic pattern). Mosaic analysis indicates focus in VD neurons.ES3 ME0. OA>11: e523 etc. [Walthall and Plunkett 1995\; ER]" "che-3" "[C.elegansII] e1124 : non-chemotactic to sodium ion, slightly small\; defective osmotic avoidance\; defective dauer formation\; males impotent\; ciliated neurons have abnormal stunted ultrastructure\; Dyf (no FITC uptake)\; octopamine deficient. ES2 ME0. OA>30: e1379, e1253 (pka che-8), p801 (pka osm-2), m443mut, mn333mut,sa129, etc. Also hf5 (pka caf-2, resistant to30 mM caffeine\;no gross phenotype\; Dyf). High forward mutation frequency. [Lewis and Hodgkin 1977\; Starich et al. 1995\; NJ\; SP\; DR]" "let-535" "[C.elegansII] h993 : mid larval lethal. OA1: h999 (similar). [McKim et al. 1992\; KR]" "let-538" "[C.elegansII] h990 : sterile adult. NA1. [McKim et al. 1992\; KR]" "mau-2" "[C.elegansII] qm4 : kinky Unc, Egl, neuroanatomical defects\; short excretory canals\; Egl\; some lethality\; full zygotic rescue, almost complete maternal rescue, no maternal rescue of Egl. OA2 (qm5, qm40). [MQ]" "spe-12" "[C.elegansII] hc76 : hermaphrodites produce nonfunctional sperm fertilization defective\; males are fertile. Similar phenotype in hc76\/Df. Spermatids activated by ionophores\; arrest as spiky intermediates after protease activation. Self-fertility <1\% (16C or 25C). ES2 (adult). NA1. Cloned: transcript only in spermatogenic germ line, predicted protein novel? [L'Hernault et al. 1988\; Shakes and Ward 1989a\; BA]" "lin-10" "[C.elegansII] e1439 : adult hermaphrodite vulvaless (penetrance 95\%) HME2\; adult male wildtype ME3. Similar phenotype in e1439\/Df. OA>5\; e1438, n299, n1299, n1329, n1638amb, etc.C loned: encodes predicted 407aa novel protein\;antibody staining indicates ubiquitous,cytoplasmic. [Kim and Horvitz 1990\; MT\; SD]" "unc-109" "[C.elegansII] n499dm : recessive lethal, embryonic arrest\; n499\/+is uncoordinated, paralysed, muscle defective. ES3. NA1. [Park and Horvitz 1986a]" "let-80" "[C.elegansII] s96 : L1 lethal. NA1. [Rose and Baillie 1980\; KR]" "let-89" "[C.elegansII] s133 : L1 lethal. NA1. [McKim et al. 1992\; KR]" "mei-1" "[C.elegansII] b284 : Mel, embryonic lethality, abnormal oocyte meiosis leading to lethal aneuploidy. Normal male meiosis.OA>20: ct46dm,ts (gf allele, normal meiosis followed by abnormal mitoses), intragenic revertants of ct46 eg ct44ct99 (putative null, abnormal meiosis), ct46ct82 (antimorphic), ct46ct103 (viable, weak Him), additional phenotypic classes. See also mei-2, mel-26, zyg-9. Cloned: two transcripts encoding 472 and 475 aa predicted proteins with similarity to ATPases. Antibody stains meiotic spindles I and II. [Mains et al. 1990, Clark-Maguire and Mains 1994\; HR]" "let-84" "[C.elegansII] s91 : late larval lethal. NA1. [Rose and Baillie 1980\; KR]" "lin-28" "[C.elegansII] n719 : precocious heterochronic alterations in many ectodermal lineages, more severe than lin-14(null)\; precocious abnormal vulva development\; Egl\; abnormal cuticle formation\; only three molts\; hermaphrodite and male V5.pa make ray cells in L2\; gonadal development normal. Late lineages less affected if animal develops via dauer stage. ES3 ME0. OA3: n947, n1119, n1120 (all resemble n719). Cloned: 1.5 and 1.6 kb transcripts, encode predicted Y-box protein. [Liu and Ambros 1991\; Arasu et al. 1992\; GR\; VT]" "unc-120" "[C.elegansII] st364ts : progressive paralysis at 20C\; mature adults very sluggish at 15C\; number of thick and thin filaments variably reduced. Sterile at 25C. [RW]" "ceh-6" "[C.elegansII] mg60 : embryonic or L1 lethal, malformed rectum,rectal rupture at or after 2-fold stage. mg60 is 1.6 kb deletion derived from Tc1 insertion pk33. Antibody stains strong or transiently in a variety of neuronal tissues, excretory cell, rectal cells Y, K, F, B, U. Encodes homeoprotein, POU III subclass. [Burglin et al. 1989\; TB]" "gon-2" "[C.elegansII] q362 :partial maternal effect gonadless (Z1 and Z4 often fail to divide). OA3: q388ts (zygotic sterile at 25C, fertile 15C, upshift gives Gon progeny), dx12, dx13. Cloned : cosmid rescue (T01H8)[EJ]" "fer-6" "[C.elegansII] hc6ts : hermaphrodites and males grown at 25C produce few sperm with defective pseudopods and retention of fibrous bodies. Self-fertility 1\% (25C) 50\% (16C). TSP L4. ES2 (adult). NA1. (hc23ts (pak fer-5) is probably reisolate of hc6). [Ward et al. 1981\; BA]" "daf-8" "[C.elegansII] m85ts : constitutive dauer formation at 25C, reversible by shift to 15C\; Type C Egl at all temperatures\; dark intestine\; Srf-6 at 16C. ES3 (L3). OA7: e1393ts (weak allele), sa233 (Egl, clumpy), etc.Cloned:[Malone and Thomas 1994\; DR\; JT]" "fer-1" "[C.elegansII] hc1ts : hermaphrodites and males grown at 25C produce nonfunctional nonmotile sperm with short pseudopods\; membranous organelles fail to fuse with sperm plasma membrane\; TSP in L4. Similar phenotype in hcl\/Df. ES2 (adult). Self-fertility < 1\% (25C) 100\% (16C). Sperm normal if grown <25C.OA7: hc80 (nonconditional), hc24 (leaky ts), b232 etc. Cloned: cosmid rescue (C02D7). 7 kb transcript, encodes probable novel protein. [Ward et al. 1981\; BA]" "ces-1" "[C.elegansII] n703 : sisters of NSM, I2 fail to undergo programmed cell death (gf allele). OA2 (gf): n1895, n1896 (similar).lf alleles (probable null) wild type but suppress ces-2 mutations. Cloned: encodes zinc finger protein, most related to snail of Drosophila. [Ellis and Horvitz 1991\; MT]" "ces-1" "[C.elegansII] n703 : sisters of NSM, I2 fail to undergo programmed cell death (gf allele). OA2 (gf): n1895, n1896 (similar).lf alleles (probable null) wild type but suppress ces-2 mutations.Cloned: encodes zinc finger protein, mostrelated to snail of Drosophila.[Ellis and Horvitz 1991\; MT]" "evl-9" "[C.elegansII] ar121 : everted vulva, sterile\; abnormal L4 vulval invagination\; abnormal uterus\; distal germ line abnormal\; abnormal oocytes\; no sperm. NA1. [Seydoux et al., 1993]" "evl-16" "[C.elegansII] ar93 : everted vulva, sterile\; no L4 vulval invagination\; abnormal uterus and oocytes\; distal germ line abnormal. NA1. [Seydoux et al., 1993]" "evl-17" "[C.elegansII] ar94 : everted vulva, sterile\; no L4 vulval invagination\; abnormal uterus and oocytes\; distal germ line abnormal. NA1. [Seydoux et al., 1993]" "sup-17" "[C.elegansII] n316 : allele and lineage non-specific suppressor of lin-12 dominant mutations,weakly dominant\; phenotype alone is recessive Dpy, recessive Egl\; abnormal vulval cell lineages\; male tail abnormal\; Egl and Dpy phenotypes stronger at 25C. ES2 ME0. Similar degree of suppression of lin-12(dom) in nDf24\/+ and n316\/+\; also n316\/nDf24 is maternal effect lethal. OA>5: n1260 (weakly sd,ts (15C phenotype non-Dpy non-Egl very weak suppressor ME3\; 25C phenotype similar to n316), n1258, n1306 etc. [Trent et al. 1983\; JT\; MT]" "egl-31" "[C.elegansII] n472 : moderate to severe bloating, insensitive to serotonin and imipramine\; some animals formbag-of-worms (20\%) or rupture at vulva\; sex muscles variably defective because of abnormalities in early M lineage\; Unc poor backing phenotype\; Lon?. ES2 (adult) ES2 (other stages). ME0 (males have M lineage defect also). NA1. [Trent et al. 1983\; CZ\; MT]" "let-536" "[C.elegansII] h882 : late larval lethal. NA1. [McKim et al. 1992\; KR]" "let-541" "[C.elegansII] h886 : early larval lethal. NA1. [KR]" "tax-2" "[C.elegansII] p671 : defects in chemotaxis (all attractants), athermotactic\; Odr\; dye-filling reveals some amphid and phasmid axon defects. OA5: p691, p694. ks10, etc. [Dusenbery 1976\; CX\; FK]" "mel-26" "[C.elegansII] ct61dm,ts : dominant maternal effect lethal, at 25C most embryos from ct61\/+ mothers have early cleavage defects, arrest prior to morphogenesis\; at 15C impenetrant maternal effect Vab. More severe defects in progeny from homozygous mothers.OA1: revertant ct61sb4 is a recessive maternal-effect lethal. [Mains et al. 1990\; HR]" "adn-1" "[C.elegansII] rh38 (Unc and slightly Dpy, many axon trajectories are abnormal, excretory canals are short, distal tip cells detach from germ cells, and first polar bodies rest in abnormally posterior positions. rh38\/+ is not Unc, but has axonal, canal, distal tip cell, and polar body abnormalities. rh38\/Df is approximately wild-type. The intragenic revertants are impenetrant Uncs), rh240, rh38rh272,rh38rh408, rh38rh409, rh38rh410. [NJ]" "egl-32" "[C.elegansII] n155ts : moderate bloating, variable drug response\;partially temperature-sensitive\; suppressible by daf-3. ES2 (adult). ME3 (some males have abnormal somatic gonads, some have abnormal or feminized germ lines). NA1. [Trent et al. 1983\; MT]" "dyf-5" "[C.elegansII] mn400 :defective in dye (FITC or DiO) filling of amphid and phasmid neurons. Animals slightly short. Chemotaxis defective. ME2 [Starich et al. 1995]" "aph-1" "[C.elegansII] zu123 : maternal effect lethal, no anterior pharynx\;resembles Glp-1 embryonic phenotype but no Lag or germ line phenotypes. Maternal rescue complete.OA1: zu147 (weaker allele). [JJ]" "aph-1" "[C.elegansII] zu123 : maternal effect lethal, no anterior pharynx\;resembles Glp-1 embryonic phenotype but no Lag or germ line phenotypes. Maternal rescue complete.OA1: zu147 (weaker allele).[JJ]" "mec-8" "[C.elegansII] e398amb : touch insensitive lethargic\; disrupted fasciculation of amphid and phasmid channelcilia\; Dyf. Synthetic lethal with some unc-52(e444)\; Pat. ES2 ME2. NA16:mn364 (recessive lethal, Pat), mn412 (Mel, Gro). u74, u456, rh170, mn472, u391. See also smu. Cloned: encodes protein with two copies of RNP predicted RNA binding domain. [Perkins et al. 1986\; Lundquist and Herman 1994\; SP\; NJ\; EH\; TU]" "nob-3" "[C.elegansII] ct315 : homozygotes L1 or embryonic lethal, malformed posterior. Cloned: cosmid rescue. [BW]" "eat-16" "[C.elegansII] ad702 : strong Eat: slippery isthmus and corpus. [Avery 1993\; DA]" "lep-1" "[C.elegansII] bx37sd : male tail tip is pointy and protrudes beyond the posterior edge of the fan, 100\%penetrant. No hermaphrodite phenotype. OA1: bx42sd (92\% penetrant). [DF]" "egl-33" "[C.elegansII] n151ts : moderate to severe bloating at 25C, insensitive to serotonin and imipramine\;some animals form bag-of-worms (40\%) or rupture at vulva\; Gro\; Unc kinker phenotype at 25C. ES3 (adult 25C), ES2 (larvae 25C). ME2. NA1. [Trent et al. 1983\; MT]" "fog-3" "[C.elegansII] q469 : XX animals transformed into females, XO animals somatically male, make oocytes in germ line. q469\/Df similar. No dominant phenotypes. ES3 (adult XX), ME0.OA>10: q441, q443, q470, q520fdi, q502uvp,oz137, oz147. [Ellis and Kimble 1995\; RE]" "lin-11" "[C.elegansII] n389 : adult hermaphrodite vulvaless (penetrance 100\%)\; 2ary lineages become symmetrical\;HME0\; slightly uncoordinated\; adult male slightly uncoordinated\; wildtype morphology ME1. OA3: n382 (resembles n389), n672sd (n672\/+ is 5\% Vul), n566 (weaker allele HME2)). Cloned: encodes LIM class homeoprotein. lin-11:lacZ expressed in some VPC 2ary descendants, some gonadal cells, VC neurons, some head neurons. [Freyd et al. 1990\; MT]" "dpy-24" "[C.elegansII] s71 : weak dumpy\; abnormal DTC migration. ES3 (adult) ES1 (larvae). NA1. [Hedgecock et al. 1987\; BC\; BS]" "aph-2" "[C.elegansII] Mutation maternal effect lethal, no anterior pharynx\;resembles Aph-1\; Egl.Cloned: novel protein, 722 aa with signal sequence\; antibody staining indicates APH-2 present on membranes of all late oocytes and early blastomeres. [JJ]" "daf-16" "[C.elegansII] m26 : defective dauer formation. Suppresses Age phenotype of age-1, daf-2. ES1. ME3. OA>10: m27 (pka daf-17), mg11 (possible defect in maintenance of dauer state). [Gottlieb and Ruvkun 1994\; DR\; GR]" "lin-41" "[C.elegansII] ma104 : heterochronic defect in L4\/A switch. [VT]" "che-13" "[C.elegansII] e1805 : Dyf (no FITC uptake by amphids or phasmids)\; severely shortened axonemes and ectopic assembly of ciliary structures and microtubules in many sensory neurons\; defective in osmotic avoidance and dauer formation. ES1 ME0. OA2: m523mut, n1520. [Perkins et al. 1986\; Starich et al. 1995\; DR\; SP]" "srf-2" "[C.elegansII] yj262 : increased binding of anti-cuticle antiserum, ectopic lectin WGA binding, no labelling with L1-specific mAb M38. Gross morphology WT.OA>20: yj133, yj422, ct104, ct117, dv1, dv2, dv37etc. All alleles recessive. [Hemmer et al. 1991\; Link et al. 1992\; AT\; CL]" "mad-2" "[C.elegansII] qm62 : adults short, lethargic but hyperactive for foraging movement, very rapid pumping after touch\; tails abnormal in both sexes\; very slow development\; high larval lethality\; full zygotic and maternal rescue. OA1 (qm58). [MQ]" "rad-1" "[C.elegansII] mn155 : extremely hypersensitive to UV, X and gamma irradiation\; not hypersensitive to UV-psoralen. ES1 ME3. NA1. [Hartman and Herman 1982\; Hartman and Marshall 1992\;PH]" "sqv-5" "[C.elegansII] n3039 : morphology of L4 vulva abnormal (invagination considerably reduced)\; hermaphrodites self-sterile. [MT]" "him-2" "[C.elegansII] e1065 : self progeny 2\% XO male\; 1.5\% ova are nullo-X\; some associated sterility.ES2 (progeny). ME3. NA1. [Hodgkin et al. 1979]" "ego-2" "[C.elegansII] om33 : recessive enhancer of glp-1(bn18) at 20C, also interacts with glp-4(om14). NA1. [Qiao et al. 1995\; EL]" "vab-10" "[C.elegansII] e698 : degenerate head, bent dorsally or ventrally\; penetrance 50\%\; generally poor growth\; adult male tail invariably thin fan and rays reduced in size\; Mua (defective muscle attachment). ES3\/1 ME0. NA1. [Hodgkin 1974\; NJ]" "cod-10" "[C.elegansII] sy38 : males fail to initiate mating behavior, have a variable tail abnormality which can include abnormal rays, breaks in the alae and occasional pseudovulvae-like structures. NA1. [PS]" "phm-2" "[C.elegansII] ad538 : pharyngeal grinder cannot assume full forward position, terminal bulb muscles appear short (too strong?)\; space behind the grinder is usually distorted into a continuously open cavity\; male spicules protrude.ES2, ME0. OA1: ad597. [Avery 1993\; DA]" "unc-75" "[C.elegansII] e950 : weak coiler especially in reverse\; moves forward well\; sluggish\; short\; Ric. ES3 ME2. OA2: h1041, h1042 (both lethal)[Brenner 1974\; Nguyen et al. 1995\; KR\; RM]" "spe-9" "[C.elegansII] hc52ts : hermaphrodites and males grown at 25C produce motile sperm that are fertilization defective. Self-fertility < 1\% (25C) 100\% (16C). ES2 (adult). OA3: hc88ts,also nonconditional alleles. [L'Hernault et al. 1988\; SL]" "ram-1" "[C.elegansII] bx34 : adult males have lumpy, amorphous ray morphology\; bx34\/+ has variably swollen raytips\; fails to complement unlinked ram mutations\;hermaphrodite WT. ME3. NA1. [Baird and Emmons 1990\; PB]" "cod-2" "[C.elegansII] sy43 : males unable to insert spicules during mating,spicule muscle defect. [PS]" "pex-1" "[C.elegansII] dx8 : sterile, pachytene exit blocked in hermaphrodite oogenesis, germline phenotype resembles mpk-1and mek-2 mutants. NA1. [EJ]" "emb-20" "[C.elegansII] g27ts,mm : osmotically sensitive eggs at 25.6C (leaky at 25C) 96\% arrest during early proliferation. Escapers viable F1 Emb. At 16C viable. OA1: g26[Cassada et al. 1981\; RC]" "unc-101" "[C.elegansII] m1des : coiler\; very sluggish, moves poorly\; slightly Egl\; slightly short\; defecation defects, abnormal FITC staining\; subviable. Adult males have abnormal tails and spicules.OA>8: rh6, sy108, sy161, sy241. Mutations suppress weak Vul mutants such as let-23(sy1)\; Muv phenotype in combination with sli-1. Cloned: encodes clathrin adaptor protein,ortholog of mouse AP47 (>75\% identity, AP47 can substitute for unc-101). [Lee et al. 1994\; DR\; PS]" "ced-1" "[C.elegansII] e1735 : programmed cell deaths abnormal, dying cells arrest at highly refractile stage\; killer cells fail to engulf target cells\; engulfment group A (ced-1,6,7)\; no gross phenotype. ES1. OA>10: n1506spo, e1754,e1797, e1798, e1799, e1800, e1801, e1814, n691, n21506, n2000, n2092 (all alleles similar)[Hedgecock et al. 1983\; Ellis et al. 1991\; MT]" "let-47" "[C.elegansII] h1319 : lethal. NA1. [KR]" "let-45" "[C.elegansII] h1292: lethal. NA1. [KR]" "let-46" "[C.elegansII] h1297 : lethal. OA3: h1330, h1337, h1359. [KR]" "let-48" "[C.elegansII] h1320 : lethal. NA1. [KR]" "par-6" "[C.elegansII] zu170spo : maternal effect lethal, resembles Par-3 but terminal arrest with more gut differentiation\; improper P granule localization. Dominant suppressor of weak par-2 mutations.OA2: zu174, zu222. [JJ\; KK]" "gro-3" "[C.elegansII] e2556spo,mat : no obvious zygotic phenotype\; in absence of maternal rescue, homozygotes are very slow-growing, slow-moving, Egl, tend to avoid bacterial lawn. ES0(zygotic), ES2. ME1. e2556 spontaneous in N2 background. NA1. [CB]" "smu-1" "[C.elegansII] mn415 : suppresses Mec (touch insensitive) and Dyf (dye-filling defective) phenes of mec-8(u218ts), Mec phene of mec-8(mn472ts), Dyf phene of most mec-8 alleles, variable cold-sensitive arrest of mec-8(u74) and mec-8(mn463), Unc phene of unc-52(e669su250ts) and synthetic lethality of mec-8(u218ts)\; unc-52(e669su250ts). Essentially WT phenotype alone. OA2: mn417, mn433 [Lundquist and Herman 1994\; SP]" "aex-6" "[C.elegansII] sa24 : defecation defective, moderately to severely constipated, expulsion muscle contraction (Exp) missing in about 9 of 10 defecation cycles, anterior body contraction (aBoc) usually also missing, slightly sluggish and slight egg laying defect (Egl). [Thomas 1990\; JT]" "glp-4" "[C.elegansII] bn2ts : hermaphrodites raised at 25C sterile,~12 germ line nuclei, non-reflexed gonad arms\; males at 25C ~16 germ line nuclei, normal soma. Germ cells arrested at meiotic prophase. Fertile at 16C\; TSP throughout larval development.OA3: om14 (proliferation normal\; oocytes small,irregular\; other germline abnormalities), om23 (weaker phenotypes), om24. Also probable intragenic revertants of bn2:bn2bn39, bn2bn40 (some fertility at 25C). [Beanan and Strome 1992\; Qiao et al. 1995\; EL\; SS]" "pry-1" "[C.elegansII] mu38 : adult males make no alae but instead have ectopic rays. Hermaphrodites are sometimes Muv. The descendants of QR stay in the posterior. The postderid is often missing. Causes late ectopic expression of lin-39, mab-5, and egl-5. See also spy. [CF]" "unc-100" "[C.elegansII] su149sd : slow, small, dumpyish\; male bursa swollen\; su149\/+ is slightly slow and small. ES3 ME0. OA2: su115 etc. [Zengel and Epstein 1980\; HE]" "let-202" "[C.elegansII] e1720 : lethal. NA1. [Anderson and Brenner 1984]" "unc-59" "[C.elegansII] e261 : poor backward movement, forward better\; thin\; vulva variably abnormal, often protrusive, sometimes ruptured\; many postembryonic lineage abnormalities resulting from variable failures in cytokinesis\; gonad lineages sometimes defective\; variable defects in neuroanatomy\; males have very abnormal tail anatomy. ES2 ME0. OA3: e1005 (pka unc-88), e1465, n391. [Brenner 1974\; White et al. 1982\; MT]" "let-201" "[C.elegansII] e1716 : lethal. NA1. [Anderson and Brenner 1984]" "let-203" "[C.elegansII] e1717 : lethal. NA1. [Anderson and Brenner 1984]" "eat-9" "[C.elegansII] e2337 : slightly starved, irregular pumping. NA1. [Avery 1993\; DA]" "let-204" "[C.elegansII] e1719 : lethal. NA1. [Anderson and Brenner 1984]" "eat-18" "[C.elegansII] ad820sd : Eat\; homozygote has slow pharyngeal pumping, lacks I-phase transients in the EPG, and is starved. (ES3). ad820\/+ pumps slower than wild type but faster than ad820\/ad820 and is not very starved (ES1). OA1. [DA]" "unc-95" "[C.elegansII] su106sd : very slow or paralysed, Egl\; abnormal variable muscle birefringence, disorganized sarcomeres with collections of thin filaments. ES3. OA3: su33amb (similar phenotypes, ME0), etc. [Zengel and Epstein 1980\; HE]" "lev-10" "[C.elegansII] x17 : almost normal movement in absence of drug, weakly resistant to 1 mM levamisole. ES2. NA1. [Lewis et al. 1980, 1987\; ZZ]" "exc-4" "[C.elegansII] rh133 : excretory canal defect. Vacuolesappear in canal during embryogenesis, and drastically shorten canal by hatch. Animals are pale, slightly unc, and are often killed by growth of large vacuoles at the excretory cell body. Defect visible by low-power microscopy. Affects tail spike ??? OA1: n2400[NJ]" "let-205" "[C.elegansII] e1722 : lethal. NA1. [Anderson and Brenner 1984]" "lev-11" "[C.elegansII] x12 : slightly long, uncoordinated, mild twitcher phenotype\; grows well in 1 mM levamisole\; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. OA6: x1 (twitcher), e1724 (lethal). Also Pat (paralysed arrest at two-fold) alleles: st536 (severe paralysis),st577, st566 (some pharyngeal pumping. Greatly reduced staining for tropomyosin, probably corresponds to structural gene tmy-1. [Lewis et al. 1980\; Williams and Waterston 1994\; HK\; ZZ]lfeLet-23 FErtility effector\/regulator.PS." "let-206" "[C.elegansII] e1721 : lethal. NA1. [Anderson and Brenner 1984]" "let-207" "[C.elegansII] e1723 : lethal. NA1. [Anderson and Brenner 1984]" "gus-1" "[C.elegansII] b405 : beta-glucuronidase activity reduced > 99\%. No gross phenotype. ES1. NA11: b410 (slight activity), gb25 etc.Also intragenic revertants e.g. gb94b410. Probable structural gene. [Sebastiano et al. 1986\; NA]" "sur-2" "[C.elegansII] ku9 : suppressor of let-60(gf)\; pleiotropic effects, some gonadal abnormality, vulval defects, larval lethality, Egl, male tail defects\; ku9\/Df stronger Vul phenotype. OA7: ku9, ku31, ku42, ku115amb (all similar to ku9\; all nonsense mutations), ku60 (Egl non-Vul) etc. Cloned: 5kb transcript, enriched in embryo and early larva\; encodes predicted 1586 aa novel protein. sur-2:lacZ expressed in VPC during vulval differentiation. [Singh and Han 1995\; MH]" "unc-122" "[C.elegansII] e2520 : medium coiler at all stages. Moves forward well when stimulated, tends to coil up when moving backwards or at rest. Coiling usually ventral, occasionally dorsal. ES2 ME1\/ME2. NA1. [CB]" "mad-1" "[C.elegansII] qm39 : hatchlings short and deformed, resembleDpy-17\; at later stages variable, anterior body short, posterior half thin\; high larval lethality\; full zygotic rescue, almost complete maternal rescue. NA1. [MQ]" "let-49" "[C.elegansII] st44 : mid-larval lethal. NA1. [Anderson and Brenner 1984\; RW]" "aex-5" "[C.elegansII] sa23 : defecation defective, moderate to severe constipation, expulsion muscle contraction (Exp) missing in about 9 of 10 defecation cycles, anterior body contraction (aBoc) usually missing as well, adult males unaffected and mate well. OA3: sa41, sa42, sa43 (all similar) [Thomas 1990\; JT]" "unc-54" "[C.elegansII] e190 : limp paralysed phenotype at all stages\; larvae can move slightly more than adults\; Egl\; muscle ultrastructure very disorganized few thick filaments. ES3 ME0. OA>50 (recessive): e1108amb,e1301ts, e675sd and s291 (in frame internal deletion mutants, almost paralysed slight twitchers), etc. Also unusual suppressor alleles, OA>15: s74 (dominant suppressor of unc-22(s12), recessive slow, stiff\; normal muscle ultrastructure) Also dominant antimorphic alleles, OA>10:e1152sd (severe rigid paralysis, small\;e1152\/+ paralysed weaker phenotype. ES3 ME0),r344 (recessive lethal, r344\/+ severely paralysed), etc. Intragenic revertants have recessive paralysed phenotype. Some recessive alleles (r274, e1420 etc.) are dominant antimorphs in smg background. Cloned: encodes MHC B (MYO-4), major bodywall muscle myosin heavy chain. 6 kb message,1117 aa protein. Extensive molecular analysis. [Epstein et al. 1974\; McLachlan and Karn 1982\;Dibb et al. 1989\; Bejsovec and Anderson 1990\; TR\; RW]" "let-50" "[C.elegansII] st33 : early larval lethal. NA1. [Anderson and Brenner 1984\; RW]" "let-208" "[C.elegansII] e1718 : lethal. NA1. [Anderson and Brenner 1984]" "ces-2" "[C.elegansII] n732 : sisters of NSM (but not I2) fail to undergo programmed cell death. Cloned: encodes protein related to bZIP transcription factors. [Ellis and Horvitz 1991\; MT]" "ces-2" "[C.elegansII] n732 : sisters of NSM (but not I2) fail to undergo programmed cell death.Cloned: encodes protein related to bZIP transcription factors.[Ellis and Horvitz 1991\; MT]" "rec-1" "[C.elegansII] s180 : increases meiotic recombination in gene clusters, reduces recombination on chromosome arms\; distribution of crossovers in Rec-1 approximates physical map. ES1, ME3. NA1. [Rose and Baillie 1979\; Zetka and Rose 1995\; KR]"