"spe-13" "[C.elegansII] hc137ts : at 25C, spermatids can activate to form crawling sperm, unable to fertilize. Low hermaphrodite self-fertility at 15C. NA1. [L'Hernault et al. 1988\; SL]" "spe-15" "[C.elegansII] hc75ts : at 25C, spermatids can activate to form crawling sperm, unable to fertilize. Low hermaphrodite self-fertility at 15C. NA1. [L'Hernault et al. 1988\; SL]" "let-546" "[C.elegansII] h227 : lethal. NA1. [KR]" "let-547" "[C.elegansII] h277 : lethal. NA1. [KR]" "let-362" "[C.elegansII] h86 : embryonic lethal. OA1: h93. [Howell et al. 1987\; KR]" "mab-20" "[C.elegansII] bx24 : displacements and fusions in rays 1,2,3,4,8,9\; R1,2,4 probably transformed to R3. Variable bulges in posterior body region. OA1: bx61ts (weaker). [Baird et al. 1991\; Chow and Emmons 1994\; EM]" "let-549" "[C.elegansII] h193 : lethal. NA1. [KR]" "cib-3" "[C.elegansII] t1008 : Mel?[GE]" "let-365" "[C.elegansII] h108 : sterile adult. OA2: h129, h295 (sterile adult). [Howell et al. 1987\; KR]" "let-360" "[C.elegansII] h96 : late larval lethal. NA1. [Howell et al. 1987\; KR]" "let-357" "[C.elegansII] h89 : sterile adult. OA1: h132. [Howell et al. 1987\; KR]" "let-515" "[C.elegansII] h730 : early larval lethal. OA3:h223 (late larval lethal), h139, h149 (both Mel). [KR]" "let-550" "[C.elegansII] h291 : sterile adult. NA1. [KR]" "let-574" "[C.elegansII] h317 : sterile adult. NA1. [KR]" "let-575" "[C.elegansII] h345 : lethal. OA1: h728. [KR]" "let-576" "[C.elegansII] h816 : early larval lethal. OA1: h494. [KR]" "let-577" "[C.elegansII] h503 : early larval lethal. NA1. [KR]" "let-578" "[C.elegansII] h512 : lethal. NA1. [KR]" "let-579" "[C.elegansII] h705 : mid larval lethal. NA1. [KR]" "let-580" "[C.elegansII] h709 : lethal. NA1. [KR]" "let-581" "[C.elegansII] h725 : mid larval lethal. OA1: h876 (similar). [KR]" "let-582" "[C.elegansII] h726 : lethal. NA1. [KR]" "let-583" "[C.elegansII] h738 : early\/mid larval lethal. NA1. [KR]" "let-584" "[C.elegansII] h743 : sterile adult. OA1: h746 (similar). [KR]" "let-586" "[C.elegansII] h846 : mid larval lethal. NA1. [KR]" "let-587" "[C.elegansII] h849 : late larval lethal. NA1. [KR]" "let-368" "[C.elegansII] h121 : early larval lethal. OA1:h826 (sterile adult, not rescued by mating). [Howell et al. 1987\; KR]" "let-372" "[C.elegansII] h126 : sterile adult. NA1. [Howell et al. 1987\; KR]" "let-585" "[C.elegansII] h784 : early larval lethal. NA1. [KR]" "let-517" "[C.elegansII] h264 : lethal. OA2: h757, h1398. [KR]" "let-518" "[C.elegansII] h316 : embryonic\/early larval lethal. NA1. [KR]" "let-369" "[C.elegansII] h125 : early larval lethal. OA1: h864 (mid larval lethal). [Howell et al. 1987\; KR]" "let-356" "[C.elegansII] h83 : mid-larval lethal. OA3: h501, h679, h871. [Howell and Rose 1990\; KR]" "let-589" "[C.elegansII] h319 : Mel, embryonic arrest. NA1. [KR]" "let-373" "[C.elegansII] h234 : early larval lethal. OA2: h70, h573 (early larval lethal). [Howell and Rose 1990\; KR]" "let-366" "[C.elegansII] h112 : mid-larval lethal. OA6: h265 (lethal), etc. [Howell and Rose 1990\; KR]" "lin-44" "[C.elegansII] n1792 : polarities of B, F, U, T divisions reversed. n1792\/Df similar. Mosaic analysis indicates non-autonomous action. OA1: n2111 (similar). Cloned: encodes member of Wnt family. lin-44:lacZ and lin-44:GFP expressed in tail tip hypodermis. [Herman et al. 1995\; EH\; MT\; SP]" "let-353" "[C.elegansII] h46 : mid-larval lethal. NA1. [Howell and Rose 1990\; KR]" "let-374" "[C.elegansII] h251 : mid-larval lethal. NA1. [Howell and Rose 1990\; KR]" "let-354" "[C.elegansII] h79 : mid-larval lethal, no dominant effect. OA>20 (recessive lethals), also 3 dominant alleles: ct42, ct76, ct77 (all 3 alleles lead to recessive zygotic larval lethality, dominant embryonic Mel). [Howell and Rose 1990\; Mains et al. 1990\; HR\; KR]" "let-351" "[C.elegansII] h43 : mid-larval lethal. NA1. [Howell et al. 1987\; McKim et al. 1992\; KR]" "let-613" "[C.elegansII] h198 : lethal. NA1. [KR]" "let-375" "[C.elegansII] h259 : leaky sterile adult. OA1: h391 (similar)[Howell and Rose 1990\; KR]" "mes-3" "[C.elegansII] bn35 : grandchildless, progeny undergo normal embryogenesis but develop into agametic adults\; few germ cells made. Normal P granule staining. XO germ line less affected. OA4: bn53 (stronger allele), bn21ts (100\% sterile 25C, 2\% 16C\; T-shift suggests action in early embryo). Cloned: 3.1 kb transcript, encodes novel protein. In operon with dom-3. [Capowski et al. 1991\; SS]" "let-598" "[C.elegansII] h213 : lethal. OA1: h813. [KR]" "let-519" "[C.elegansII] h405 : lethal. NA1. [KR]" "cib-1" "[C.elegansII] e2300ts : maternal effect embryonic lethal at25C, WT at 15C. TSP in oocyte, early embryo. Mutant embryos exhibit abnormal delayed cleavage of P1, P2, P3\; other pleiotropic defects. OA6: e2303 (non-conditional strict Mel), e2301,e2302, e2304, e2305, e2306 (all ts, weaker than e2300). [Schnabel and Schnabel, 1990]" "let-364" "[C.elegansII] h104 : sterile adult. NA1. [Howell et al. 1987\; KR]" "let-359" "[C.elegansII] h94 : sterile adult. NA1. [Howell et al. 1987\; KR]" "let-361" "[C.elegansII] h97 : late larval\/early adult lethal. OA3: h113, h116, h323gri. [Howell et al. 1987\; KR]" "let-363" "[C.elegansII] h98 : late larval lethal. OA4: h111 (early adult arrest), h60, h114, h131 (lethal). [Howell et al. 1987\; KR]" "sem-2" "[C.elegansII] n1343mut : Egl, hermaphrodite sex muscles adopt body wallmuscle fate.ME3. OA5: some alleles have additional phenotypes ,4 are embryonic lethal, arrest 1.5-fold with bloated head. [MT\; NH\; RW]" "let-371" "[C.elegansII] h123 : mid- to late larval lethal\/sterile adult. NA1. [Howell et al. 1987\; KR]" "let-352" "[C.elegansII] h45 : late larval lethal\/sterile adult. NA1. [Howell et al. 1987\; KR]" "let-595" "[C.elegansII] h353 : lethal. OA1: h372. [KR]" "let-388" "[C.elegansII] h88 : early larval lethal. OA2: h729, h843. [Howell et al. 1987\; KR]" "mev-3" "[C.elegansII] kn3 : increased paraquat sensitivity, hypersensitive to oxygen. [TK\; TM]" "evl-10" "[C.elegansII] ar95 : everted vulva, sterile\; abnormal L4 vulval invagination\; abnormal uterus\; distal germ line abnormal\; no sperm or oocytes. NA1. [Seydoux et al., 1993]" "let-386" "[C.elegansII] h117 : mid-larval lethal. OA4: h678, etc. [Howell et al. 1987\; KR]" "let-604" "[C.elegansII] h293 : sterile adult. OA1: h490 (similar). [KR]" "let-382" "[C.elegansII] h82 : mid-larval lethal. OA1: h476. [Howell et al. 1987\; KR]" "let-390" "[C.elegansII] h44 : late larval lethal or sterile adult. NA1. [Howell et al. 1987\; KR]" "let-607" "[C.elegansII] h402 : embryonic lethal. NA1. [KR]" "mei-2" "[C.elegansII] ct102 : Mel, embryonic arrest as mass of cells without morphogenesis\; abnormal oocyte meiosis\; dominant suppressor of mei-1(dm), mel-26(dm).OA1: ct98 (dominant suppressor of mei-1(dm), slight recessive Mel, weak Him, viable). [Mains et al. 1990\; HR]" "let-383" "[C.elegansII] h115 : early to mid-larval lethal. OA3: h389, h527, h727. [Howell et al. 1987\; [McKim et al. 1992\; KR]" "let-392" "[C.elegansII] h120 : early larval lethal. OA8: h122 etc. [Howell et al. 1987\; McKim et al. 1992\; KR]" "let-397" "[C.elegansII] h228 : early larval lethal. OA2: h221, h445. [McKim et al. 1992\; KR]" "let-544" "[C.elegansII] h692 : sterile adult. NA1. [McKim et al. 1992\; KR]" "let-605" "[C.elegansII] h312 : sterile Unc adult. h312\/Df sterile, Evl, strong coiler Unc. OA4 (all alleles Unc). [McKim et al. 1992\; KR]" "let-398" "[C.elegansII] h257 : arrests L2. NA1. Cloned: partial cosmid rescue (K01B11)[McKim et al. 1992\; KR]" "let-529" "[C.elegansII] h238 : early larval lethal. OA3. [McKim et al. 1992\; KR]" "let-399" "[C.elegansII] h273 : L4 lethal. NA1. [McKim et al. 1992\; KR]" "let-521" "[C.elegansII] h704 : L4 lethal. NA1. [McKim et al. 1992\; KR]" "let-385" "[C.elegansII] h85 : early larval lethal. Highly mutable:OA>15: h578 (spontaneous, late larval lethal),h940, etc. [Howell et al. 1987\; McKim et al. 1992\; KR]" "let-543" "[C.elegansII] h792 : L4 lethal. NA1. [McKim et al. 1992\; KR]" "let-534" "[C.elegansII] h260 : mid larval lethal, coiler Unc. OA1: h196 (mid larval lethal). Cloned: cosmid rescue (T14D10). [McKim et al. 1992\; KR]" "let-394" "[C.elegansII] h262 : early to mid-larval lethal. OA6:h361 (sterile adult), etc. Cloned: cosmid rescue (T14D10). [McKim et al. 1992\; KR]" "let-528" "[C.elegansII] h1012 : late larval lethal. OA1: h58spo (similar). [McKim et al. 1992\; KR]" "let-545" "[C.elegansII] h842 : sterile adult, very few germ line nuclei, no oocytes or sperm. NA1. Cloned: cosmid rescue (T21G5). Possibly = glh-1. [McKim et al. 1992\; KR]" "let-389" "[C.elegansII] h680 : early larval lethal. OA10: h428, h106 (both early larval lethal), h698 (late larval lethal). Complex complementation, h698\/h428 is fertile. [Howell et al. 1987\; McKim et al. 1992\; KR]" "let-400" "[C.elegansII] h269 : early to mid-larval lethal. OA5: h878, h590gri, etc. [McKim et al. 1992\; KR]" "let-520" "[C.elegansII] h690 : L4 lethal. OA1: h1003 (similar). [McKim et al. 1992\; KR]" "sem-4" "[C.elegansII] n1378 : Egl, hermaphrodite sex muscles fail to differentiate\; additional axon and lineage defects. ME0 (severe Mab), HME3. OA3: h769, n2087, n1971 (stronger allele, two mesodermal and six neuronal cell types pleiotropically affected\; 2 additional touch cells formed in tail), etc. Cloned: encodes predicted protein with 6 C2H2 zincfinger motifs. [Desai et al. 1988\; Mitani et al. 1993\; MT\; NH\; TU]" "let-522" "[C.elegansII] h735 : early larval lethal. OA2: h240, h519. [McKim et al. 1992\; KR]" "let-523" "[C.elegansII] h751 : early larval lethal. OA1: h479. [McKim et al. 1992\; KR]" "let-525" "[C.elegansII] h874 : mid larval lethal. OA1: h410[McKim et al. 1992\; KR]" "let-527" "[C.elegansII] h207 : early larval lethal. OA3: h209 (mid larval lethal), h357 (some maternalrescue to Spe adult), h932(early larval lethal). [McKim et al. 1992\; KR]" "let-539" "[C.elegansII] h938 : mid larval lethal. NA1. [McKim et al. 1992\; KR]" "let-524" "[C.elegansII] h442 : early larval lethal. OA4: h53gri, etc. [McKim et al. 1992\; KR]" "let-542" "[C.elegansII] h986 : early larval lethal. NA1. [McKim et al. 1992\; KR]" "let-540" "[C.elegansII] h884 : late larval lethal. NA1. [McKim et al. 1992\; KR]" "gld-1" "[C.elegansII] q485 : hermaphrodite germ cells enter meiosis, fail in pachytene, re-enter mitosis and form large proximal germline tumor\; males unaffected. Probable null phenotype. ES3 (adult), ME3.OA>15: multiple phenotypic classes and subclasses, class A: q268, q365 (probable nulls, resemble q485)\; class B: q93oz12 (sperm, then germ cells arrested in pachytene)\;class C: q93 (gf, Mog)\; class D: q126 (gf, Fog)\; class E: q266 (gf, Fog, abnormal oocytes)\; class F: q343 (sperm, then abnormal oocytes). Complex complementation. Cloned: encodes predicted 463 or 466 aa proteins,with similarity to shrimp GRP33, mouse Src-associated protein Sam68\; includes KH (possible RNA binding) domain. [Francis et al. 1995 \; Jones and Schedl 1995\; BS]" "let-535" "[C.elegansII] h993 : mid larval lethal. OA1: h999 (similar). [McKim et al. 1992\; KR]" "let-538" "[C.elegansII] h990 : sterile adult. NA1. [McKim et al. 1992\; KR]" "mei-1" "[C.elegansII] b284 : Mel, embryonic lethality, abnormal oocyte meiosis leading to lethal aneuploidy. Normal male meiosis.OA>20: ct46dm,ts (gf allele, normal meiosis followed by abnormal mitoses), intragenic revertants of ct46 eg ct44ct99 (putative null, abnormal meiosis), ct46ct82 (antimorphic), ct46ct103 (viable, weak Him), additional phenotypic classes. See also mei-2, mel-26, zyg-9. Cloned: two transcripts encoding 472 and 475 aa predicted proteins with similarity to ATPases. Antibody stains meiotic spindles I and II. [Mains et al. 1990, Clark-Maguire and Mains 1994\; HR]" "unc-120" "[C.elegansII] st364ts : progressive paralysis at 20C\; mature adults very sluggish at 15C\; number of thick and thin filaments variably reduced. Sterile at 25C. [RW]" "evl-9" "[C.elegansII] ar121 : everted vulva, sterile\; abnormal L4 vulval invagination\; abnormal uterus\; distal germ line abnormal\; abnormal oocytes\; no sperm. NA1. [Seydoux et al., 1993]" "evl-16" "[C.elegansII] ar93 : everted vulva, sterile\; no L4 vulval invagination\; abnormal uterus and oocytes\; distal germ line abnormal. NA1. [Seydoux et al., 1993]" "evl-17" "[C.elegansII] ar94 : everted vulva, sterile\; no L4 vulval invagination\; abnormal uterus and oocytes\; distal germ line abnormal. NA1. [Seydoux et al., 1993]" "let-536" "[C.elegansII] h882 : late larval lethal. NA1. [McKim et al. 1992\; KR]" "let-541" "[C.elegansII] h886 : early larval lethal. NA1. [KR]" "fog-3" "[C.elegansII] q469 : XX animals transformed into females, XO animals somatically male, make oocytes in germ line. q469\/Df similar. No dominant phenotypes. ES3 (adult XX), ME0.OA>10: q441, q443, q470, q520fdi, q502uvp,oz137, oz147. [Ellis and Kimble 1995\; RE]" "aph-2" "[C.elegansII] Mutation maternal effect lethal, no anterior pharynx\;resembles Aph-1\; Egl.Cloned: novel protein, 722 aa with signal sequence\; antibody staining indicates APH-2 present on membranes of all late oocytes and early blastomeres. [JJ]" "lin-41" "[C.elegansII] ma104 : heterochronic defect in L4\/A switch. [VT]" "srf-2" "[C.elegansII] yj262 : increased binding of anti-cuticle antiserum, ectopic lectin WGA binding, no labelling with L1-specific mAb M38. Gross morphology WT.OA>20: yj133, yj422, ct104, ct117, dv1, dv2, dv37etc. All alleles recessive. [Hemmer et al. 1991\; Link et al. 1992\; AT\; CL]" "ram-1" "[C.elegansII] bx34 : adult males have lumpy, amorphous ray morphology\; bx34\/+ has variably swollen raytips\; fails to complement unlinked ram mutations\;hermaphrodite WT. ME3. NA1. [Baird and Emmons 1990\; PB]" "let-47" "[C.elegansII] h1319 : lethal. NA1. [KR]" "let-45" "[C.elegansII] h1292: lethal. NA1. [KR]" "let-46" "[C.elegansII] h1297 : lethal. OA3: h1330, h1337, h1359. [KR]" "let-48" "[C.elegansII] h1320 : lethal. NA1. [KR]" "par-6" "[C.elegansII] zu170spo : maternal effect lethal, resembles Par-3 but terminal arrest with more gut differentiation\; improper P granule localization. Dominant suppressor of weak par-2 mutations.OA2: zu174, zu222. [JJ\; KK]" "glp-4" "[C.elegansII] bn2ts : hermaphrodites raised at 25C sterile,~12 germ line nuclei, non-reflexed gonad arms\; males at 25C ~16 germ line nuclei, normal soma. Germ cells arrested at meiotic prophase. Fertile at 16C\; TSP throughout larval development.OA3: om14 (proliferation normal\; oocytes small,irregular\; other germline abnormalities), om23 (weaker phenotypes), om24. Also probable intragenic revertants of bn2:bn2bn39, bn2bn40 (some fertility at 25C). [Beanan and Strome 1992\; Qiao et al. 1995\; EL\; SS]"