Parameters: pvalue 0 %id 0 mcl inflation 1.5 Processed: Citrobacter_rodentium_ICC168_FN543502_v1.embl : 4984 Enterobacter_cloacae_subsp_cloacae_NCTC_9394_v1.embl : 3725 Escherichia_coli_UPEC_ST131_v0.1.embl : 5022 Escherichia_coli_str_K-12_substr_MG1655_v2.embl : 4320 Klebsiella_pneumoniae_subsp_pneumoniae_Ecl8_v0.2.embl : 5360 Salmonella_enterica_subsp_enterica_serovar_Typhi_Ty2_v1.embl : 4322 Salmonella_enterica_subsp_enterica_serovar_Typhimurium_SL1344_v2.embl : 4515 Citrobacter_rodentium_ICC168_FN543502_v1.embl.tmp Enterobacter_cloacae_subsp_cloacae_NCTC_9394_v1.embl.tmp Escherichia_coli_UPEC_ST131_v0.1.embl.tmp Escherichia_coli_str_K-12_substr_MG1655_v2.embl.tmp Klebsiella_pneumoniae_subsp_pneumoniae_Ecl8_v0.2.embl.tmp Salmonella_enterica_subsp_enterica_serovar_Typhi_Ty2_v1.embl.tmp Salmonella_enterica_subsp_enterica_serovar_Typhimurium_SL1344_v2.embl.tmp Cluster0 23 0 7 1 1 0 1 ROD_01921(ISCro1 transposase C),ROD_06431(ISCro1 transposase C),ROD_06821(ISCro1 transposase C),ROD_08991(ISCro1 transposase C),ROD_10351(ISCro1 transposase C),ROD_12861(ISCro1 transposase C),ROD_13911(ISCro1 transposase C),ROD_23611(ISCro1 transposase C),ROD_26411(ISCro1 transposase C),ROD_26481(ISCro1 transposase C),ROD_28231(ISCro1 transposase C),ROD_28321(ISCro1 transposase C),ROD_30161(ISCro1 transposase C),ROD_31891(ISCro1 transposase C),ROD_34321(ISCro1 transposase C),ROD_35321(ISCro1 transposase C),ROD_36251(ISCro1 transposase C),ROD_38851(ISCro1 transposase C),ROD_40711(ISCro1 transposase C),ROD_45801(ISCro1 transposase C),ROD_47731(ISCro1 transposase C),ROD_50111(IS679 transposase C),pseudoROD_50161(ISEc23 transposase C (fragment)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1725(Transposase and inactivated derivatives,Transposase IS66 family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4146(Transposase and inactivated derivatives,Transposase IS66 family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4170(Transposase and inactivated derivatives,Transposase IS66 family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4886(Transposase and inactivated derivatives,Transposase IS66 family),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.134(Transposase and inactivated derivatives,Transposase IS66 family),Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.33(Transposase and inactivated derivatives,Transposase IS66 family),Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.34(Transposase and inactivated derivatives,Transposase IS66 family) pseudob4642(unknown) BN373_p01681(conserved hypothetical protein) pseudoSL1344_0992(transposase (remnant)) Cluster1 3 4 5 4 7 2 4 ROD_05171(acriflavin resistance protein B),ROD_45481(acriflavin resistance protein F),pseudoROD_24181(putative multidrug efflux pump (pseudogene)) ENC_03400(The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family),ENC_22660(The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family),ENC_35160(The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family),ENC_38060(Cation/multidrug efflux pump) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1260(Acriflavine resistance protein B,aminoglycoside/multidrug efflux system,RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family,AcrB/AcrD/AcrF family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.178(Multidrug resistance protein MdtF,multidrug efflux system protein AcrB,RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family,AcrB/AcrD/AcrF family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2472(Multidrug-efflux transporter MexB,aminoglycoside/multidrug efflux system,RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family,AcrB/AcrD/AcrF family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3519(Acriflavine resistance protein B,multidrug efflux system protein AcrB,RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family,AcrB/AcrD/AcrF family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.428(Acriflavine resistance protein B,multidrug efflux system protein AcrB,RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family,AcrB/AcrD/AcrF family) b0462(multidrug efflux system protein),b2470(aminoglycoside/multidrug efflux system),b3266(multidrug efflux system protein),b3514(anaerobic multidrug efflux transporter, ArcA-regulated) BN373_09311(acriflavine resistance protein B),BN373_11331(RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family),BN373_26531(acridine efflux pump),BN373_34621(acriflavine resistance protein D),BN373_36081(RND family multidrug efflux permease protein OqxB),BN373_43141(acriflavine resistance protein F),BN373_46821(multidrug efflux permease EefB) t0378(putative efflux pump),t2385(acriflavin resistance protein B) SL1344_0346(putative cation efflux protein),SL1344_0468(acriflavin resistance protein B),SL1344_2444(putative efflux pump),SL1344_3364(acriflavin resistance protein F) Cluster2 2 5 4 5 5 2 6 ROD_18161(putative fimbrial usher protein),ROD_29151(fimbrial usher protein FimD) ENC_03020(P pilus assembly protein, porin PapC),ENC_04120(P pilus assembly protein, porin PapC),ENC_19360(P pilus assembly protein, porin PapC),ENC_22140(P pilus assembly protein, porin PapC),ENC_47680(P pilus assembly protein, porin PapC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2333(Outer membrane usher protein fimD precursor,outer membrane usher protein,Fimbrial Usher protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3831(Outer membrane usher protein fimD precursor,long polar fimbrial outer membrane usher protein LpfC,Fimbrial Usher protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4080(Outer membrane usher protein fimD precursor,outer membrane usher protein,Fimbrial Usher protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4891(F1 capsule-anchoring protein precursor,pilin outer membrane usher protein SafC,Fimbrial Usher protein) b0532(predicted outer membrane export usher protein),b0940(predicted outer membrane usher protein),b3144(predicted outer membrane protein),b4317(outer membrane usher protein, type 1 fimbrial synthesis),pseudob1505(unknown) BN373_00821(fimbrial usher family protein),BN373_01531(fimbrial usher family protein),BN373_36241(fimbrial usher protein),BN373_39221(outer membrane usher protein fimD),BN373_40581(putative fimbrial biogenesis outer membrane usher protein) t2317(outer membrane usher protein FimD precursor),t2558(outer-membrane fimbrial usher protein) SL1344_0023(fimbrial usher protein),SL1344_0176(fimbrial usher protein),SL1344_0297(salmonella atypical fimbria outer membrane usher),SL1344_0539(outer membrane usher protein FimD precursor),SL1344_3604(outer membrane usher protein (LpfC)),SL1344_4520(Outer membrane fimbrial usher protein) Cluster3 1 0 2 0 0 15 7 ROD_21531(IS200 family transposase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1702(Transposase and inactivated derivatives,Transposase IS200 like),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1845(Transposase and inactivated derivatives,Transposase IS200 like) t0388(transposase for insertion sequence element IS200),t0456(transposase for insertion sequence element IS200),t1105(transposase for insertion sequence element IS200),t1154(transposase for insertion sequence element IS200),t1197(transposase for insertion sequence element IS200),t1554(transposase for insertion sequence element IS200),t1735(transposase for insertion sequence element IS200),t2258(transposase for insertion sequence element IS200),t2464(transposase for insertion sequence element IS200),t2909(transposase for insertion sequence element IS200),t2920(transposase for insertion sequence element IS200),t2986(transposase for insertion sequence element IS200),t2995(transposase for insertion sequence element IS200),t3019(transposase for insertion sequence element is200),t4460(transposase for insertion sequence element is200) SL1344_0885(transposase for the IS1541 insertion element),SL1344_1166(putative transposase),SL1344_1746(transposase),SL1344_1886(transposase),SL1344_2434(transposase),SL1344_3267(transposase),SL1344_3446(transposase) Cluster4 21 0 1 0 0 0 0 ROD_01901(ISCro1 transposase A),ROD_06451(ISCro1 transposase A),ROD_06841(ISCro1 transposase A),ROD_09011(ISCro1 transposase A),ROD_10371(ISCro1 transposase A),ROD_12881(ISCro1 transposase A),ROD_13931(ISCro1 transposase A),ROD_23631(ISCro1 transposase A),ROD_26441(ISCro1 transposase A),ROD_26451(ISCro1 transposase A),ROD_28251(ISCro1 transposase A),ROD_28301(ISCro1 transposase A),ROD_30181(ISCro1 transposase A),ROD_31881(ISCro1 transposase A),ROD_34341(ISCro1 transposase A),ROD_35301(ISCro1 transposase A),ROD_36231(ISCro1 transposase A),ROD_38831(ISCro1 transposase A),ROD_40691(ISCro1 transposase A),ROD_45821(ISCro1 transposase A),ROD_47751(ISCro1 transposase A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4888(IS2 repressor TnpA,Transposase) Cluster5 21 0 1 0 0 0 0 ROD_01911(ISCro1 transposase B),ROD_06441(ISCro1 transposase B),ROD_06831(ISCro1 transposase B),ROD_09001(ISCro1 transposase B),ROD_10361(ISCro1 transposase B),ROD_12871(ISCro1 transposase B),ROD_13921(ISCro1 transposase B),ROD_23621(ISCro1 transposase B),ROD_26421(ISCro1 transposase B),ROD_26461(ISCro1 transposase B),ROD_28241(ISCro1 transposase B),ROD_28311(ISCro1 transposase B),ROD_30171(ISCro1 transposase B),ROD_31882(ISCro1 transposase B),ROD_34331(ISCro1 transposase B),ROD_35311(ISCro1 transposase B),ROD_36241(ISCro1 transposase B),ROD_38841(ISCro1 transposase B),ROD_40701(ISCro1 transposase B),ROD_45811(ISCro1 transposase B),ROD_47741(ISCro1 transposase B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4887(Transposase and inactivated derivatives,IS66 Orf2 like protein) Cluster6 3 3 2 3 2 3 5 ROD_09581(anaerobic dimethyl sulfoxide reductase chain A),ROD_34401(dimethyl sulfoxide reductase),pseudoROD_34911(anaerobic dimethyl sulfoxide reductase chain (pseudogene)) ENC_12140(anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family),ENC_17870(anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family),ENC_37400(anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2297(Dimethyl sulfoxide reductase DmsA precursor,anaerobic dimethyl sulfoxide reductase subunit A,Uncharacterized anaerobic dehydrogenase,anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family,Molybdopterin oxidoreductase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3049(Dimethyl sulfoxide reductase DmsA precursor,anaerobic dimethyl sulfoxide reductase subunit A,Uncharacterized anaerobic dehydrogenase,anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family,Molybdopterin oxidoreductase) b0894(dimethyl sulfoxide reductase, anaerobic, subunit A),b1587(probable selenate reductase, periplasmic),b1588(S-and N-oxide reductase, A subunit, periplasmic) BN373_15421(anaerobic dimethyl sulfoxide reductase, A subunit),BN373_21371(anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family) t1419(putative dimethyl sulfoxide reductase subunit),t1420(putative dimethyl sulfoxide reductase subunit),t1970(anaerobic dimethyl sulfoxide reductase chain A precursor) SL1344_0902(anaerobic dimethyl sulfoxide reductase chain A precursor),SL1344_1428(putative dimethyl sulphoxide reductase subunit),SL1344_1429(putative dimethyl sulphoxide reductase subunit),SL1344_2492(dimethyl sulfoxide reductase),SL1344_4242(anaerobic dimethyl sulfoxide reductase chain) Cluster7 3 2 3 3 2 3 3 ROD_18521(L-serine deaminase 1),ROD_28371(L-serine dehydratase 2 (L-serine deaminase 2)),ROD_47641(L-serine dehydratase) ENC_06830(L-serine ammonia-lyase),ENC_30420(L-serine ammonia-lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2072(L-serine dehydratase 1,L-serine deaminase,L-serine deaminase,L-serine ammonia-lyase,Serine dehydratase alpha chain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.578(L-serine dehydratase tdcG,L-serine dehydratase TdcG,L-serine deaminase,L-serine ammonia-lyase,Serine dehydratase alpha chain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.978(L-serine dehydratase 2,L-serine deaminase,L-serine deaminase,L-serine ammonia-lyase,Serine dehydratase alpha chain) b1814(L-serine deaminase I),b2797(L-serine deaminase II),b4471(L-serine dehydratase 3) BN373_29131(L-serine ammonia-lyase 1),BN373_37851(L-serine ammonia-lyase 2) t1051(L-serine deaminase 1),t2879(L-serine dehydratase 2),t3160(L-serine dehydratase) SL1344_1755(L-serine deaminase 1),SL1344_2951(L-serine dehydratase 2 (L-serine deaminase 2)),SL1344_3212(L-serine dehydratase) Cluster8 12 0 0 0 6 0 1 ROD_02831(IS102 transposase),ROD_05221(IS102 transposase),ROD_20681(IS102 transposase),ROD_28451(IS102 transposase),ROD_28951(IS102 transposase),ROD_29281(IS102 transposase),ROD_29471(IS102 transposase),ROD_31511(IS102 transposase),ROD_33401(IS102 transposase),ROD_35171(IS102 transposase),ROD_45501(IS102 transposase),ROD_50641(IS102 transposase) BN373_26521(putative transposase, IS4),BN373_30581(plasmid pLVPK transposase),BN373_p00011(putative transposase, IS4),BN373_p00491(putative transposase, IS4),BN373_p01311(putative transposase, IS4),BN373_p01961(putative transposase, IS4) pseudoSL1344_2885A(putative transposase (pseudogene)) Cluster9 0 0 17 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.11(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.15(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.166(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.177(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.181(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.19(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.192(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.30(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.34(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.38(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.78(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.85(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.12(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.18(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.19(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.2(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.20(hypothetical protein) Cluster10 3 2 3 2 3 2 2 ROD_24131(transketolase 2),ROD_50511(transketolase 1),ROD_50601(transketolase 1) ENC_31720(transketolase),ENC_38200(transketolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1265(Transketolase 2,transketolase,Transketolase,transketolase,Transketolase, thiamine diphosphate binding domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4688(Transketolase 1,transketolase,Transketolase,transketolase,Transketolase, thiamine diphosphate binding domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.816(Transketolase 1,transketolase,Transketolase,transketolase,Transketolase, thiamine diphosphate binding domain) b2465(transketolase 2, thiamin-binding),b2935(transketolase 1, thiamin-binding) BN373_17411(transketolase),BN373_34581(transketolase),BN373_40211(transketolase) t0385(transketolase 2),t2996(transketolase) SL1344_2437(transketolase 2),SL1344_3052(transketolase) Cluster11 3 0 6 2 1 2 3 ROD_36611(phage tail fibre protein),pseudoROD_08982(putative phage tail fibre protein (pseudogene)),pseudoROD_36581(phage tail fibre protein (C-terminus)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2522(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3091(Phage tail fibre repeat),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3094(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.12(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.15(Phage tail fibre repeat),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.15(hypothetical protein) b1154(e14 prophage; predicted protein),pseudob2355(unknown) BN373_14841(putative prophage tail fiber protein) t1868(putative bacteriophage tail protein),t3433(probable variable tail fiber protein) SL1344_1930(putative bacteriophage tail fibre protein),SL1344_2211(predicted bacteriophage protein),SL1344_4135(predicted bacteriophage protein) Cluster12 3 1 3 3 2 2 2 ROD_24161(oxidoreductase),ROD_33931(putative oxidoreductase),ROD_46041(glutamate synthase (NADPH) small subunit) ENC_34620(NADPH-dependent glutamate synthase beta chain and related oxidoreductases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1262(Glutamate synthase [NADPH] small chain,putative oxidoreductase Fe-S binding subunit,Uncharacterized conserved protein,glutamate synthase, small subunit,Pyridine nucleotide-disulphide oxidoreductase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.479(Glutamate synthase [NADPH] small chain,putative oxidoreductase Fe-S binding subunit,Alkyl hydroperoxide reductase, large subunit,glutamate synthase, small subunit,Pyridine nucleotide-disulphide oxidoreductase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.869(Glutamate synthase [NADPH] small chain,putative oxidoreductase Fe-S binding subunit,Uncharacterized conserved protein,glutamate synthase, small subunit,Pyridine nucleotide-disulphide oxidoreductase) b2468(fused predicted oxidoreductase: FeS binding subunit/NAD/FAD-binding subunit),b2887(fused predicted oxidoreductase: Fe-S subunit/nucleotide-binding subunit),b3213(glutamate synthase, 4Fe-4S protein, small subunit) BN373_34611(AegA protein),BN373_42751(glutamate synthase (NADPH), small subunit) t0380(putative oxidoreductase),t3248(glutamate synthase (NADPH) small chain) SL1344_2442(putative oxidoreductase),SL1344_3303(glutamate synthase (NADPH) small chain) Cluster13 2 2 3 3 2 1 2 ROD_14851(putative sugar dehydrogenase),ROD_23031(putative sugar-phosphate dehydrogenase) ENC_12010(Mannitol-1-phosphate/altronate dehydrogenases),ENC_40000(Mannitol-1-phosphate/altronate dehydrogenases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1537(Polyol:NADP oxidoreductase,D-mannonate oxidoreductase,Mannitol-1-phosphate/altronate dehydrogenases,Mannitol dehydrogenase C-terminal domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2306(Polyol:NADP oxidoreductase,D-mannonate oxidoreductase,Mannitol-1-phosphate/altronate dehydrogenases,Mannitol dehydrogenase C-terminal domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4074(Polyol:NADP oxidoreductase,D-mannonate oxidoreductase,Mannitol-1-phosphate/altronate dehydrogenases,Mannitol dehydrogenase C-terminal domain) b1542(predicted D-mannonate oxidoreductase, NAD-dependent),b2172(Predicted D-mannonate oxidoreductase, NAD-dependent),b4323(D-mannonate oxidoreductase, NAD-dependent) BN373_21441(putative mannitol dehydrogenase),BN373_32111(mannitol dehydrogenase family protein) t3057(D-mannonate oxidoreductase) SL1344_1438(putative D-mannonate oxidoreductase),SL1344_3110(D-mannonate oxidoreductase) Cluster14 2 1 3 3 2 2 2 ROD_42561(biotin sulfoxide reductase),ROD_47581(trimethylamine-N-oxide reductase 2 precursor) ENC_01580(molybdopterin guanine dinucleotide-containing S/N-oxide reductases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.133(Trimethylamine-N-oxide reductase 2 precursor,trimethylamine N-oxide reductase I catalytic subunit,Uncharacterized anaerobic dehydrogenase,molybdopterin guanine dinucleotide-containing S/N-oxide reductases,Molybdopterin oxidoreductase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2009(Trimethylamine-N-oxide reductase 2 precursor,trimethylamine N-oxide reductase I catalytic subunit,Uncharacterized anaerobic dehydrogenase,molybdopterin guanine dinucleotide-containing S/N-oxide reductases,Molybdopterin oxidoreductase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2911(Trimethylamine-N-oxide reductase 1 precursor,trimethylamine N-oxide reductase I catalytic subunit,Uncharacterized anaerobic dehydrogenase,trimethylamine-N-oxide reductase TorA,Molybdopterin oxidoreductase) b0997(trimethylamine N-oxide (TMAO) reductase I, catalytic subunit),b1872(trimethylamine N-oxide reductase system III, catalytic subunit),b3551(biotin sulfoxide reductase) BN373_12211(biotin sulfoxide reductase homolog),BN373_45451(biotin sulfoxide reductase) t3696(trimethylamine-N-oxide reductase precursor),t3875(biotin sulfoxide reductase) SL1344_3610(biotin sulfoxide reductase),SL1344_3788(trimethylamine-N-oxide reductase precursor) Cluster15 0 0 7 6 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1604(IS1 transposase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.758(IS1 transposase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.776(IS1 transposase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.778(IS1 transposase),Escherichia_coli_UPEC_ST131_v0.1_5_5104002-5133359.23(IS1 transposase),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.144(IS1 transposase),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.55(IS1 transposase) b0021(IS1 transposase B),b0264(IS1 transposase B),b0274(IS1 transposase B),b0988(IS1 transposase B),b1893(IS1 transposase B),b3445(IS1 transposase B) BN373_p01251(putative IS1 transposase) Cluster16 13 0 0 0 1 0 0 ROD_00481(ISCro4 transposase),ROD_11331(ISCro4 transposase),ROD_12161(ISCro4 transposase),ROD_12961(ISCro4 transposase),ROD_23011(ISCro4 transposase),ROD_24951(ISCro4 transposase),ROD_28391(ISCro4 transposase),ROD_30291(ISCro4 transposase),ROD_33031(ISCro4 transposase),ROD_34671(ISCro4 transposase),ROD_35971(ISCro4 transposase),ROD_37371(ISCro4 transposase),ROD_39361(ISCro4 transposase) BN373_p00051(transposase for IS1663) Cluster17 2 2 2 2 2 2 2 ROD_43971(glycogen phosphorylase),ROD_44061(maltodextrin phosphorylase) ENC_26160(glycogen/starch/alpha-glucan phosphorylases),ENC_26220(glycogen/starch/alpha-glucan phosphorylases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.272(Maltodextrin phosphorylase,glycogen phosphorylase,glycogen/starch/alpha-glucan phosphorylases,Carbohydrate phosphorylase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.283(Maltodextrin phosphorylase,maltodextrin phosphorylase,glycogen/starch/alpha-glucan phosphorylases,Carbohydrate phosphorylase) b3417(maltodextrin phosphorylase),b3428(glycogen phosphorylase) BN373_44261(maltodextrin phosphorylase),BN373_44321(glycogen phosphorylase) t3986(glycogen phosphorylase),t3992(maltodextrin phosphorylase) SL1344_3481(maltodextrin phosphorylase),SL1344_3501(glycogen phosphorylase) Cluster18 2 2 2 2 2 2 2 ROD_28901(arabinose-proton symporter),ROD_50461(galactose-proton symporter (galactose transporter)) ENC_30880(MFS transporter, sugar porter (SP) family),ENC_31930(MFS transporter, sugar porter (SP) family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.809(Galactose transporter,D-xylose transporter XylE,Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA),MFS transporter, sugar porter (SP) family,Sugar (and other) transporter),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.896(Arabinose transporter,D-xylose transporter XylE,Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA),MFS transporter, sugar porter (SP) family,Sugar (and other) transporter) b2841(arabinose transporter),b2943(D-galactose transporter) BN373_38951(arabinose-proton symporter),BN373_40291(galactose-proton symporter) t2926(L-arabinose isomerase),t3003(galactose-proton symport) SL1344_2994(arabinose-proton symporter),SL1344_3066(galactose-proton symport (galactose transporter)) Cluster19 2 2 2 2 2 2 2 ROD_30261(glucarate dehydratase-related protein),ROD_30271(glucarate dehydratase) ENC_30300(D-glucarate dehydratase),ENC_30310(D-glucarate dehydratase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.988(Glucarate dehydratase-related protein,galactonate dehydratase,L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily,glucarate dehydratase,Mandelate racemase / muconate lactonizing enzyme, C-terminal domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.989(Glucarate dehydratase,galactonate dehydratase,L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily,glucarate dehydratase,Mandelate racemase / muconate lactonizing enzyme, C-terminal domain) b2787((D)-glucarate dehydratase 1),b2788(glucarate dehydratase-related protein, substrate unknown) BN373_37741(glucarate dehydratase),BN373_37751(glucarate dehydratase-related protein) t2869(probable glucarate dehydratase 1),t2870(probable glucarate dehydratase 2) SL1344_2941(probable glucarate dehydratase 1),SL1344_2942(probable glucarate dehydratase) Cluster20 2 2 2 2 2 2 2 ROD_15701(respiratory nitrate reductase 2 beta chain),ROD_17811(respiratory nitrate reductase 1 beta chain) ENC_07870(respiratory nitrate reductase beta subunit),ENC_09750(respiratory nitrate reductase beta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2360(Respiratory nitrate reductase 2 beta chain,tetrathionate reductase subunit B,nitrate reductase, beta subunit,4Fe-4S dicluster domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2618(Respiratory nitrate reductase 1 beta chain,tetrathionate reductase subunit B,Uncharacterized Fe-S center protein,nitrate reductase, beta subunit,4Fe-4S dicluster domain) b1225(nitrate reductase 1, beta (Fe-S) subunit),b1467(nitrate reductase 2 (NRZ), beta subunit) BN373_24621(nitrate reductase 2, beta subunit),BN373_28071(nitrate reductase 1, beta subunit) t1489(respiratory nitrate reductase 2 beta chain),t1672(respiratory nitrate reductase 1 beta chain) SL1344_1509(respiratory nitrate reductase 2 beta chain),SL1344_1691(respiratory nitrate reductase 1 beta chain) Cluster21 2 2 2 2 2 2 2 ROD_15681(nitrite extrusion protein),ROD_17831(nitrite extrusion protein) ENC_07840(nitrite extrusion protein (nitrite facilitator)),ENC_09770(nitrite extrusion protein (nitrite facilitator)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2358(Nitrite facilitator 2,nitrate/nitrite transport protein NarU,nitrite transporter,Major Facilitator Superfamily),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2620(Nitrite facilitator 1,nitrate/nitrite transport protein NarU,nitrite transporter,Major Facilitator Superfamily) b1223(nitrate/nitrite transporter),b1469(nitrate/nitrite transporter) BN373_24601(nitrite extrusion protein 2),BN373_28091(nitrite extrusion protein 1) t1487(nitrite extrusion protein),t1674(nitrite extrusion protein) SL1344_1507(nitrite extrusion protein),SL1344_1693(nitrite extrusion protein (nitrite facilitator)) Cluster22 2 2 2 2 2 2 2 ROD_14521(fumarate hydratase class I, aerobic),ROD_34851(fumarate hydratase class I, anaerobic) ENC_12840(fumarase),ENC_41940(fumarase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2271(Fumarate hydratase class I, aerobic,fumarate hydratase FumA,Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain,hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type,Fumarate hydratase (Fumerase)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4345(Fumarate hydratase class I, anaerobic,fumarate hydratase FumB,Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain,hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type,Fumarate hydratase (Fumerase)) b1612(fumarate hydratase (fumarase A), aerobic Class I),b4122(anaerobic class I fumarate hydratase (fumarase B)) BN373_20721(fumarate hydratase),BN373_21021(fumarate hydratase) t1336(Fumarate hydratase class I, aerobic),t4207(fumarate hydratase class I) SL1344_1398(Fumarate hydratase class I, aerobic),SL1344_4237(fumarate hydratase class I) Cluster23 3 2 2 1 2 2 2 ROD_25341(chaperone (heat-shock protein F84.1)),ROD_27811(T6SS protein Cts1V),ROD_34231(T6SS protein Cts2V) ENC_07370(type VI secretion ATPase, ClpV1 family),ENC_08960(type VI secretion ATPase, ClpV1 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1148(Heat shock protein F84.1,protein disaggregation chaperone,Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,ATP-dependent chaperone protein ClpB,AAA domain (Cdc48 subfamily)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.951(hypothetical protein,protein disaggregation chaperone,Predicted ATPase,type VI secretion ATPase, ClpV1 family,AAA domain (Cdc48 subfamily)) b2592(protein disaggregation chaperone) BN373_19551(type VI secretion ATPase, ClpV1 family),BN373_35691(ATP-dependent chaperone ClpB) t2591(ClpB-like protein),t2616(ClpB protein) SL1344_0266(conserved hypothetical protein (SPI-6 associated)),SL1344_2620(ClpB protein (heat shock protein f84.1)) Cluster24 2 1 2 2 3 2 2 ROD_13091(succinylornithine transaminase),ROD_44501(acetylornithine/succinyldiaminopimelate aminotransferase) ENC_25710(acetylornithine aminotransferase apoenzyme /succinyldiaminopimelate aminotransferase apoenzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2132(Succinylornithine transaminase,bifunctional succinylornithine transaminase/acetylornithine transaminase,Ornithine/acetylornithine aminotransferase,succinylornithine transaminase family,Aminotransferase class-III),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.336(Acetylornithine/succinyldiaminopimelate aminotransferase,bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein,Ornithine/acetylornithine aminotransferase,succinylornithine transaminase family,Aminotransferase class-III) b1748(succinylornithine transaminase, PLP-dependent),b3359(bifunctional acetylornithine aminotransferase/ succinyldiaminopimelate aminotransferase) BN373_18441(succinylornithine transaminase),BN373_20491(putative succinylornithine transaminase),BN373_43821(acetylornithine/succinyldiaminopimelate aminotransferase) t1182(succinylornithine transaminase),t4037(acetylornithine aminotransferase) SL1344_1238(Acetylornithine/succinyldiaminopimelate aminotransferase),SL1344_3435(acetylornithine aminotransferase) Cluster25 2 2 2 2 2 2 2 ROD_09721(formate acetyltransferase 1),ROD_47631(keto-acid formate acetyltransferase) ENC_17810(formate acetyltransferase 1),ENC_33650(keto acid formate lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3043(Formate acetyltransferase 1,putative formate acetyltransferase 2,formate acetyltransferase,Pyruvate formate lyase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.576(Ketobutyrate formate-lyase,putative formate acetyltransferase 2,formate acetyltransferase,Pyruvate formate lyase) b0903(pyruvate formate lyase I),b3114(pyruvate formate-lyase 4/2-ketobutyrate formate-lyase) BN373_15471(formate acetyltransferase),BN373_28711(putative formate acetyltransferase) t1961(formate acetyltransferase 1),t3161(probable formate acetyltransferase) SL1344_0910(formate acetyltransferase 1),SL1344_3213(probable formate acetyltransferase) Cluster26 2 1 2 2 3 2 2 ROD_01181(aromatic amino acid transport protein),pseudoROD_05661(phenylalanine-specific permease (pseudogene)) ENC_46250(Gamma-aminobutyrate permease and related permeases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3434(Phenylalanine-specific permease,phenylalanine transporter,Amino acid transporters,GABA permease,Amino acid permease),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3878(General aromatic amino acid permease,aromatic amino acid transporter,Amino acid transporters,GABA permease,Amino acid permease) b0112(aromatic amino acid transporter),b0576(phenylalanine transporter) BN373_06061(aromatic amino acid transport protein AroP),BN373_11071(amino acid permease family protein),BN373_19891(putative aromatic amino acid transport protein AroP) t0156(aromatic amino acid transport protein),t2293(phenylalanine-specific permease) SL1344_0150(aromatic amino acid transport protein AroP),SL1344_0556(phenylalanine-specific permease) Cluster27 2 2 1 1 4 2 2 ROD_05931(ferrienterobactin TonB-dependent receptor (enterobactin outer-membrane receptor)),pseudoROD_17541(TonB-dependent outer membrane siderophore receptor (pseudogene)) ENC_19110(TonB-dependent siderophore receptor),ENC_21490(TonB-dependent siderophore receptor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3415(Enterobactin outer-membrane receptor,outer membrane receptor FepA,Outer membrane receptor for ferrienterochelin and colicins,TonB-dependent siderophore receptor,TonB dependent receptor) b0584(iron-enterobactin outer membrane transporter) BN373_00551(ferrienterobactin receptor),BN373_11801(ferrienterobactin receptor),BN373_18671(TonB-dependent siderophore receptor),BN373_p02121(outer membrane receptor FepA) t2283(ferrienterobactin receptor precursor),t2672(TonB-dependent outer membrane siderophore receptor protein) SL1344_0573(ferrienterobactin receptor precursor),SL1344_2762(TonB-dependent outer membrane siderophore receptor protein) Cluster28 2 2 2 2 2 1 2 ROD_43651(leu/ile/val ABC transporter, substrate-binding protein),ROD_43681(leucine-specific ABC transporter, substrate-binding protein) ENC_26480(L-leucine-binding protein),ENC_26510(L-leucine-binding protein/L-isoleucine-binding protein/L-valine-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.241(Leu/Ile/Val-binding protein precursor,leucine ABC transporter subunit substrate-binding protein LivK,urea ABC transporter, urea binding protein,Receptor family ligand binding region),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.245(Leucine-specific-binding protein precursor,leucine ABC transporter subunit substrate-binding protein LivK,urea ABC transporter, urea binding protein,Receptor family ligand binding region) b3458(leucine transporter subunit),b3460(leucine/isoleucine/valine transporter subunit) BN373_44551(high-affinity branched-chain amino acid ABC transporter, periplasmic leucine-specific-binding protein),BN373_44581(high-affinity branched-chain amino acid ABC transporter, periplasmic Leu/Ile/Val-binding protein) t3958(leucine-specific binding protein) SL1344_3530(leucine-specific binding protein),SL1344_3532(leu/ile/val/thr-binding protein) Cluster29 2 1 2 2 2 2 2 ROD_22071(multidrug resistance protein),ROD_22081(multidrug resistance protein) ENC_40940(Cation/multidrug efflux pump) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1634(Multidrug transporter MdtC,multidrug efflux system subunit MdtC,RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family,AcrB/AcrD/AcrF family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1635(Multidrug transporter MdtC,multidrug efflux system subunit MdtB,RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family,AcrB/AcrD/AcrF family) b2075(multidrug efflux system, subunit B),b2076(multidrug efflux system, subunit C) BN373_31301(multidrug resistance protein MdtB),BN373_31311(multidrug resistance protein MdtC) t0744(putative RND-family transporter protein),t0745(putative RND-family transporter protein) SL1344_2104(putative RND-family transporter protein),SL1344_2105(putative RND-family transporter protein) Cluster30 2 1 2 2 2 2 2 ROD_06101(carbon starvation protein A),ROD_48371(putative carbon starvation protein) ENC_21350(Carbon starvation protein, predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3400(Carbon starvation protein A,carbon starvation protein A,Carbon starvation protein, predicted membrane protein,Carbon starvation protein CstA),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4045(Inner membrane protein YjiY,carbon starvation protein A,Carbon starvation protein, predicted membrane protein,Carbon starvation protein CstA) b0598(carbon starvation protein),b4354(predicted inner membrane protein) BN373_04011(carbon starvation family protein),BN373_11941(carbon starvation protein A) t2268(carbon starvation protein A),t4582(probable carbon starvation protein) SL1344_0588(carbon starvation protein A),SL1344_4463(probable carbon starvation protein) Cluster31 5 0 0 6 0 1 0 pseudoROD_19261(Rhs protein (pseudogene)),pseudoROD_26491(Rhs protein (pseudogene)),pseudoROD_28201(Rhs protein (pseudogene)),pseudoROD_40661(Rhs protein (pseudogene)),pseudoROD_45781(Rhs protein (pseudogene)) b0497(rhsD element protein),b0700(rhsC element core protein RshC),b3482(rhsB element core protein RshB),b3593(rhsA element core protein RshA),pseudob0703(unknown),pseudob1456(unknown) t2566(Rhs-family protein) Cluster32 11 0 0 1 0 0 0 ROD_02711(ISCro3 transposase),ROD_08131(ISCro3 transposase),ROD_11361(ISCro3 transposase),ROD_17531(ISCro3 transposase),ROD_18951(ISCro3 transposase),ROD_22841(ISCro3 transposase),ROD_25311(ISCro3 transposase),ROD_40121(ISCro3 transposase),ROD_41801(ISCro3 transposase),ROD_42611(ISCro3 transposase),ROD_47091(ISCro3 transposase) pseudob4573(unknown) Cluster33 2 0 2 2 2 2 2 ROD_37731(elongation factor Tu),ROD_44801(Elongation factor tu (EF-Tu)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.357(Elongation factor Tu 1,elongation factor Tu,GTPases - translation elongation factors,translation elongation factor Tu,Elongation factor Tu GTP binding domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4518(P-43,elongation factor Tu,GTPases - translation elongation factors,translation elongation factor Tu,Elongation factor Tu GTP binding domain) b3339(protein chain elongation factor EF-Tu (duplicate of tufB)),b3980(protein chain elongation factor EF-Tu (duplicate of tufA)) BN373_43611(translation elongation factor Tu),BN373_49731(translation elongation factor Tu) t3481(elongation factor Tu),t4060(elongation factor Tu) SL1344_3412(elongation factor Tu),SL1344_4085(elongation factor Tu) Cluster34 2 0 2 2 2 2 2 ROD_15691(respiratory nitrate reductase 2 alpha chain),ROD_17821(respiratory nitrate reductase 1 alpha chain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2359(Respiratory nitrate reductase 2 alpha chain,anaerobic dimethyl sulfoxide reductase subunit A,Uncharacterized anaerobic dehydrogenase,nitrate reductase, alpha subunit,Molybdopterin oxidoreductase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2619(Respiratory nitrate reductase 1 alpha chain,anaerobic dimethyl sulfoxide reductase subunit A,Uncharacterized anaerobic dehydrogenase,nitrate reductase, alpha subunit,Molybdopterin oxidoreductase) b1224(nitrate reductase 1, alpha subunit),b1468(nitrate reductase 2 (NRZ), alpha subunit) BN373_24611(nitrate reductase 2, alpha subunit),BN373_28081(nitrate reductase 1, alpha subunit) t1488(respiratory nitrate reductase 2 alpha chain),t1673(respiratory nitrate reductase 1 alpha chain) SL1344_1508(respiratory nitrate reductase 2 alpha chain),SL1344_1692(respiratory nitrate reductase 1 alpha chain) Cluster35 1 1 2 2 2 2 2 ROD_01941(lysine decarboxylase, constitutive) ENC_47090(L-lysine decarboxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3793(Lysine decarboxylase, constitutive,lysine decarboxylase LdcC,Orn/Lys/Arg decarboxylase, major domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4327(Lysine decarboxylase, inducible,lysine decarboxylase CadA,Orn/Lys/Arg decarboxylase, major domain) b0186(lysine decarboxylase 2, constitutive),b4131(lysine decarboxylase, acid-inducible) BN373_06911(lysine decarboxylase, constitutive),BN373_10641(putative lysine decarboxylase, constitutive) t0236(lysine decarboxylase),t0297(lysine decarboxylase) SL1344_0235(lysine decarboxylase),SL1344_2521(lysine decarboxylase) Cluster36 0 0 0 11 0 0 0 b0259(IS5 transposase and trans-activator),b0552(IS5 transposase and trans-activator),b0656(IS5 transposase and trans-activator),b1331(IS5 transposase and trans-activator),b1370(IS5 transposase and trans-activator),b1994(IS5 transposase and trans-activator),b2030(IS5 transposase and trans-activator),b2192(IS5 transposase and trans-activator),b2982(IS5 transposase and trans-activator),b3218(IS5 transposase and trans-activator),b3505(IS5 transposase and trans-activator) Cluster37 2 0 2 2 1 2 2 ROD_21771(dTDP-glucose 4,6-dehydratase),ROD_39591(dTDP-glucose 4,6-dehydratase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1672(dTDP-glucose 4,6-dehydratase,dTDP-glucose 4,6 dehydratase,dTDP-glucose 4,6-dehydratase,NAD dependent epimerase/dehydratase family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4737(dTDP-glucose 4,6-dehydratase 2,dTDP-glucose 4,6-dehydratase,dTDP-glucose 4,6-dehydratase,NAD dependent epimerase/dehydratase family) b2041(dTDP-glucose 4,6 dehydratase, NAD(P)-binding),b3788(dTDP-glucose 4,6-dehydratase) BN373_49161(dTDP-glucose 4,6-dehydratase) t0775(dTDP-glucose 4,6-dehydratase),t3375(UDP-N-acetylglucosamine epimerase) SL1344_2074(dTDP-glucose 4,6-dehydratase),SL1344_3881(UDP-N-acetylglucosamine epimerase (UDP-GlcNAc-2-epimerase)) Cluster38 2 2 2 2 1 0 2 ROD_06991(ornithine decarboxylase isozyme, inducible),ROD_50221(ornithine decarboxylase, constitutive) ENC_20360(ornithine decarboxylase),ENC_32250(ornithine decarboxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3305(Ornithine decarboxylase, constitutive,ornithine decarboxylase,Orn/Lys/Arg decarboxylase, major domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.784(Ornithine decarboxylase, constitutive,ornithine decarboxylase,Orn/Lys/Arg decarboxylase, major domain) b0693(ornithine decarboxylase isozyme, inducible),b2965(ornithine decarboxylase, constitutive) BN373_40531(ornithine decarboxylase, constitutive) SL1344_0683(ornithine decarboxylase, inducible (ec 4.1.1.17)),SL1344_3089(ornithine decarboxylase, constitutive (ec 4.1.1.17)) Cluster39 3 0 5 2 1 0 0 pseudoROD_03411(IS3 family transposase B (pseudogene)),pseudoROD_47821(IS3 family transposase A (fragment)),pseudoROD_47831(IS3 family transposase B (fragment)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4092(Transposase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4093(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4158(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.580(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.581(Transposase) pseudob4587(unknown),pseudob4623(unknown) BN373_39801(IS911 transposase orfB) Cluster40 2 0 2 1 1 3 2 ROD_19831(phage tail protein),ROD_36501(phage tail protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3101(Phage protein D,Phage late control gene D protein (GPD)),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.3(Phage protein D,Phage late control gene D protein (GPD)) pseudob2083(unknown) BN373_14911(late control gene D protein) t2660(putative bacteriophage late gene regulator),t3444(putative regulator of late gene expression),t4295(putative regulator of late gene expression) SL1344_2643(bacteriophage late control gene),SL1344_2666(putative regulator of late gene expression) Cluster41 1 0 2 2 2 2 2 ROD_07091(putative oligopeptide transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3296(Dipeptide permease D,dipeptide/tripeptide permease D,amino acid/peptide transporter (Peptide:H+ symporter),POT family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4328(Probable dipeptide and tripeptide permease YjdL,dipeptide/tripeptide permease D,amino acid/peptide transporter (Peptide:H+ symporter),POT family) b0709(dipeptide and tripeptide permease D),b4130(predicted dipeptide and tripeptide permease) BN373_10651(amino acid/peptide transporter),BN373_12911(amino acid/peptide transporter) t0296(putative transmembrane transport protein),t2166(PTR2-family transport protein) SL1344_0691(PTR2-family transport protein),SL1344_2522(putative transmembrane transport protein) Cluster42 3 1 1 1 2 2 1 ROD_03661(putative fimbrial chaperone protein),ROD_27791(fimbrial chaperone protein),ROD_29371(putative fimbrial chaperone protein) ENC_46520(P pilus assembly protein, chaperone PapD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3843(Chaperone protein papD precursor,putative chaperone protein EcpD,Gram-negative pili assembly chaperone, N-terminal domain) b0140(predicted periplasmic pilin chaperone) BN373_10561(gram-negative pili assembly chaperone),BN373_39101(gram-negative pili assembly chaperone) t0189(chaperone protein EcpD precursor),t2522(fimbrial chaperone protein) SL1344_0334(fimbrial chaperone protein) Cluster43 1 1 3 2 2 1 1 ROD_47511(tagatose-1,6-bisphosphate aldolase) ENC_33800(tagatose-bisphosphate aldolase catalytic subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1618(D-tagatose-1,6-bisphosphate aldolase subunit GatY,tagatose-bisphosphate aldolase,Fructose/tagatose bisphosphate aldolase,class II aldolase, tagatose bisphosphate family,Fructose-bisphosphate aldolase class-II),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.440(D-tagatose-1,6-bisphosphate aldolase subunit GatY,tagatose-bisphosphate aldolase,Fructose/tagatose bisphosphate aldolase,class II aldolase, tagatose bisphosphate family,Fructose-bisphosphate aldolase class-II),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.555(D-tagatose-1,6-bisphosphate aldolase subunit KbaY,tagatose-bisphosphate aldolase,Fructose/tagatose bisphosphate aldolase,class II aldolase, tagatose bisphosphate family,Fructose-bisphosphate aldolase class-II) b2096(D-tagatose 1,6-bisphosphate aldolase 2, catalytic subunit),b3137(tagatose 6-phosphate aldolase 1, kbaY subunit) BN373_08371(putative fructose-1,6-bisphosphate aldolase, class II),BN373_48281(fructose-bisphosphate aldolase, class II family) t3173(tagatose-bisphosphate aldolase) SL1344_3226(tagatose-bisphosphate aldolase) Cluster44 2 1 1 1 2 2 2 ROD_00901(peptidoglycan synthetase (penicillin-binding protein 3)),ROD_18611(penicillin-binding protein) ENC_45960(peptidoglycan synthetase FtsI) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3904(Peptidoglycan synthase FtsI precursor,peptidoglycan synthase FtsI,Membrane carboxypeptidase/penicillin-binding protein,stage V sporulation protein D,Penicillin binding protein transpeptidase domain) b0084(transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3)) BN373_05771(peptidoglycan synthetase FtsI),BN373_29231(putative peptidoglycan synthetase FtsI) t0126(penicillin-binding protein 3 precursor),t1042(penicillin-binding protein) SL1344_0122(penicillin-binding protein 3 precursor),SL1344_1765(penicillin-binding protein) Cluster45 2 0 0 3 0 1 4 ROD_02411(putative phage tail fibre assembly protein),ROD_25781(putative phage tail fibre assembly protein) b1373(Rac prophage; predicted tail fiber assembly protein),b1546(Qin prophage; predicted tail fibre assembly protein),pseudob0561(unknown) t3434(hypothetical protein) SL1344_0989(bacteriophage tail fibre assembly protein),SL1344_1800(Phage Tail Assembly Protein),SL1344_2550(DNA Binding protein),SL1344_2551(predicted bacteriophage protein) Cluster46 7 0 1 2 0 0 0 ROD_02111(putative adhesin autotransporter),ROD_03891(putative adhesin autotransporter),ROD_03921(putative adhesin autotransporter),ROD_15731(putative adhesin autotransporter),ROD_16391(putative outer membrane autotransporter),ROD_27631(putative outer membrane autotransporter),pseudoROD_10521(putative adhesin autotransporter (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2715(hypothetical protein) pseudob4491(unknown),pseudob4696(unknown) Cluster47 1 1 2 2 0 2 2 ROD_34981(putative fimbrial usher protein) ENC_32850(P pilus assembly protein, porin PapC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1374(Outer membrane usher protein papC precursor,putative fimbrial outer membrane usher protein StfC,Fimbrial Usher protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.651(Outer membrane usher protein papC precursor,fimbrial outer membrane usher protein StdB,Fimbrial Usher protein) b0718(predicted outer membrane protein),pseudob4661(unknown) t2857(outer membrane usher protein),t2939(probable outer membrane fimbrial usher protein) SL1344_0197(outer membrane usher protein stfc (putative fimbrial outer membrane usher)),SL1344_3007(probable outer membrane fimbrial usher protein) Cluster48 2 2 0 2 0 2 2 ROD_38881(putative membrane protein),ROD_38891(putative membrane protein) ENC_00250(sugar (Glycoside-Pentoside-Hexuronide) transporter),ENC_00260(sugar (Glycoside-Pentoside-Hexuronide) transporter) b3876(predicted transporter),b3877(predicted transporter) t3603(putative membrane permease),t3604(putative membrane permease) SL1344_3963(putative membrane transport protein),SL1344_3964(putative membrane permease) Cluster49 2 1 1 1 1 2 2 ROD_15421(putative glycogen debranching protein),ROD_43941(glycogen debranching enzyme) ENC_26250(isoamylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.269(Glycogen debranching enzyme,glycogen debranching enzyme,glycogen debranching enzyme GlgX,Carbohydrate-binding module 48 (Isoamylase N-terminal domain)) b3431(glycogen debranching enzyme) BN373_44351(glycogen debranching enzyme) t1471(putative glycogen debranching protein),t3983(glycogen operon protein) SL1344_1488(glycogen debranching protein),SL1344_3504(glycogen operon protein) Cluster50 1 1 2 2 2 1 1 ROD_30251(putative glucarate transporter) ENC_30320(d-galactonate transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.567(D-galactarate permease,sn-glycerol-3-phosphate transporter,Arabinose efflux permease,D-galactonate transporter,Major Facilitator Superfamily),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.987(D-glucarate permease,putative 3-hydroxyphenylpropionic transporter MhpT,Arabinose efflux permease,D-galactonate transporter,Major Facilitator Superfamily) b2789(predicted D-glucarate transporter),b3127(predicted (D)-galactarate transporter) BN373_37761(putative glucarate transporter),BN373_42031(putative transport protein) t2871(probable glucarate transporter) SL1344_2943(probable glucarate transporter) Cluster51 1 3 1 2 1 1 1 ROD_21981(putative polysaccharide export protein) ENC_02670(Periplasmic protein involved in polysaccharide export),ENC_40490(Periplasmic protein involved in polysaccharide export),ENC_41050(Periplasmic protein involved in polysaccharide export) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1650(polysaccharide export protein Wza,polysaccharide export protein EpsE,Polysaccharide biosynthesis/export protein) b0983(lipoprotein required for formation of the O-antigen capsule, predicted exopolysaccharide export protein),b2062(lipoprotein required for capsular polysaccharide translocation through the outer membrane) BN373_31151(polysaccharide export protein Wza) t0754(putative polysaccharide export protein) SL1344_2095(putative polysaccharide export protein) Cluster52 1 3 1 2 1 1 1 ROD_21961(tyrosine-protein kinase) ENC_02650(capsular exopolysaccharide family),ENC_40510(capsular exopolysaccharide family),ENC_41070(capsular exopolysaccharide family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1652(Tyrosine-protein kinase wzc,tyrosine kinase,Capsular polysaccharide biosynthesis protein,exopolysaccharide transport protein family,Chain length determinant protein) b0981(cryptic autophosphorylating protein tyrosine kinase Etk),b2060(protein-tyrosine kinase) BN373_31131(tyrosine autokinase) t0756(putative tyrosine-protein kinase) SL1344_2093(tyrosine-protein kinase) Cluster53 2 2 1 1 2 1 1 ROD_17881(nitrite reductase [NAD(P)H] large subunit),ROD_44441(nitrite reductase [NAD(P)H] large subunit) ENC_07780(assimilatory nitrate reductase (NADH) beta subunit /assimilatory nitrite reductase (NAD(P)H) small subunit /assimilatory nitrite reductase (NAD(P)H) large subunit precursor),ENC_25780(assimilatory nitrite reductase (NAD(P)H) large subunit precursor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.330(Nitric oxide reductase FlRd-NAD(+) reductase,nitrite reductase subunit NirD,Uncharacterized conserved protein,nitrite reductase [NAD(P)H], large subunit,Pyridine nucleotide-disulphide oxidoreductase) b3365(nitrite reductase, large subunit, NAD(P)H-binding) BN373_28141(nitrite reductase (nad(p)h), large subunit),BN373_43891(nitrite reductase [NAD(P)H], large subunit) t4031(nitrite reductase large subunit) SL1344_3441(nitrite reductase large subunit) Cluster54 1 3 1 1 2 1 1 ROD_42631(dipeptide ABC transporter, substrate-binding protein) ENC_01520(ABC-type dipeptide transport system, periplasmic component),ENC_09410(ABC-type dipeptide transport system, periplasmic component),ENC_11040(ABC-type dipeptide transport system, periplasmic component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.140(Dipeptide-binding protein,antimicrobial peptide ABC transporter periplasmic binding protein SapA,ABC-type oligopeptide transport system, periplasmic component,nickel ABC transporter, nickel/metallophore periplasmic binding protein,Bacterial extracellular solute-binding proteins, family 5 Middle) b3544(dipeptide transporter) BN373_24941(periplasmic dipeptide transport protein),BN373_45371(dipeptide ABC transporter, periplasmic dipeptide-binding protein) t3885(periplasmic dipeptide transport protein precursor) SL1344_3596(periplasmic dipeptide transport protein precursor) Cluster55 2 1 0 2 2 1 2 ROD_15621(formate dehydrogenase, nitrate-inducible, major subunit),ROD_38641(formate dehydrogenase-O, major subunit) ENC_00430(formate dehydrogenase alpha subunit) b1474(formate dehydrogenase-N, alpha subunit, nitrate-inducible),b3894(formate dehydrogenase-O, large subunit) BN373_24471(formate dehydrogenase, nitrate inducible, alpha subunit, selenocysteine-containing),BN373_48221(formate dehydrogenase-O, major subunit, selenocysteine-containing) t3583(formate dehydrogenase-O major subunit) SL1344_1500(formate dehydrogenase N (nitrate-inducible, alpha subunit)),SL1344_3984(putative 1 formate dehydrogenase-O, major subunit) Cluster56 2 1 1 2 2 1 1 ROD_03551(putrescine importer),ROD_21541(putative amino acid permease) ENC_41540(Amino acid transporters) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1700(Low-affinity putrescine importer PlaP,putative fructoselysine transporter,Amino acid transporters,amino acid transporter,Amino acid permease) b1296(putrescine importer),b2014(putrescine importer, low affinity) BN373_16351(putrescine importer),BN373_30741(amino acid permease family protein) t0806(putative amino acid transporter protein) SL1344_2045(putative amino acid transporter protein) Cluster57 1 1 2 2 1 1 2 ROD_07271(cytochrome d ubiquinol oxidase subunit 1) ENC_20050(cytochrome bd quinol oxidase subunit 1 apoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2922(Cytochrome bd-II oxidase subunit 1,cytochrome bd-II oxidase subunit 1,Bacterial Cytochrome Ubiquinol Oxidase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3266(Cytochrome d ubiquinol oxidase subunit 1,cytochrome d terminal oxidase subunit 1,Bacterial Cytochrome Ubiquinol Oxidase) b0733(cytochrome d terminal oxidase, subunit I),b0978(cytochrome bd-II oxidase, subunit I) BN373_13101(cytochrome d ubiquinol oxidase, subunit I) t2136(cytochrome d ubiquinol oxidase subunit I) SL1344_0722(cytochrome d ubiquinol oxidase subunit I),SL1344_1720(cytochrome bd-II oxidase subunit I (pseudogene)) Cluster58 1 1 2 1 2 2 1 ROD_06131(conserved hypothetical protein) ENC_21140(Predicted phosphoadenosine phosphosulfate sulfotransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1755(hypothetical protein,Predicted phosphoadenosine phosphosulfate sulfotransferase,sulfate adenylyltransferase, small subunit,Domain of unknown function (DUF3440)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3395(hypothetical protein,Predicted phosphoadenosine phosphosulfate sulfotransferase,phosphoadenosine phosphosulfate reductase,Domain of unknown function (DUF3440)) b0602(conserved protein) BN373_12261(IbrA protein),BN373_p02171(conserved hypothetical protein) t2264(conserved hypothetical protein),t4277(conserved hypothetical protein) SL1344_0593(conserved hypothetical protein) Cluster59 1 1 3 1 3 0 1 ROD_19661(putative transposase B) ENC_35930(Transposase and inactivated derivatives) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1852(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2023(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.611(Integrase core domain) b3558(IS150 transposase B) BN373_11521(IS150 putative transposase),BN373_31971(is150 putative transposase),BN373_45631(putative IS3 family transposase orfB) SL1344_0319(putative IS3 transposase) Cluster60 1 1 1 1 2 2 2 ROD_06341(two-component sensor kinase) ENC_32230(Signal transduction histidine kinase regulating citrate/malate metabolism) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3379(Sensor histidine kinase DpiB,sensor histidine kinase DpiB,Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation,putative PEP-CTERM system histidine kinase,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b0619(sensory histidine kinase in two-component regulatory system with citB) BN373_05111(sensor kinase CitA),BN373_05411(sensor histidine kinase) t0055(sensor kinase CitA),t2242(sensor kinase DpiB) SL1344_0054(two-component sensor kinase),SL1344_0613(sensor kinase DpiB) Cluster61 1 1 1 1 2 2 2 ROD_06351(two-component response regulator) ENC_32240(Response regulator of citrate/malate metabolism) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3378(Destabilizer of plasmid inheritance,two-component response regulator DpiA,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain) b0620(DNA-binding response regulator in two-component regulatory system with citA) BN373_05101(transcriptional regulatory protein dpiA),BN373_05401(DNA-binding response regulator) t0054(transcriptional regulatory protein CitB),t2241(transcriptional regulatory protein DpiA) SL1344_0053(transcriptional regulatory protein citb),SL1344_0614(transcriptional regulatory protein dpia) Cluster62 2 2 1 1 2 1 1 ROD_32141(outer membrane lipoprotein),ROD_37341(outer membrane lipoprotein blc) ENC_03050(Bacterial lipocalin),ENC_42510(Bacterial lipocalin) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4306(Outer membrane lipoprotein blc precursor,outer membrane lipoprotein Blc,Bacterial lipocalin,Lipocalin-like domain) b4149(outer membrane lipoprotein (lipocalin), cell division and growth function) BN373_01621(outer membrane lipoprotein Blc),BN373_03591(outer membrane lipoprotein Blc) t4391(putative lipoprotein) SL1344_4276(putative lipoprotein) Cluster63 0 0 0 0 0 9 0 t0234(transposase for insertion sequence element IS200),t0244(transposase for insertion sequence element IS200),t0593(transposase for insertion sequence element IS200),t1406(transposase for insertion sequence element IS200),t1587(transposase for insertion sequence element IS200),t1681(transposase for insertion sequence element IS200),t1832(transposase for insertion sequence element IS200),t1837(transposase for insertion sequence element IS200),t2054(transposase for insertion sequence element is200) Cluster64 1 0 2 5 0 0 1 ROD_49871(IS3 transposase B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4160(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_5_5104002-5133359.17(Integrase core domain) b0299(IS3 transposase B),b0372(IS3 transposase B),b0541(IS3 transposase B),b1026(IS3 transposase B),b2089(IS3 transposase B) SL1344_2754(putative transposase) Cluster65 3 0 2 2 0 0 2 ROD_02421(putative phage tail fibre protein),ROD_25791(putative phage tail fibre protein),pseudoROD_12051(putative tail fiber protein (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1846(Uncharacterized conserved protein,Prophage tail fibre N-terminal),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2731(Prophage tail fibre N-terminal) b1372(Rac prophage; predicted tail fiber protein),b1547(Qin prophage; predicted side tail fibre assembly protein) SL1344_0988(putative Tail Fiber Protein),SL1344_2552(similar to a DNA recombinase) Cluster66 1 1 5 2 0 0 0 ROD_49721(conserved hypothetical protein) ENC_36090(Domain of unknown function (DUF932).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1716(Domain of unknown function (DUF932)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4131(Domain of unknown function (DUF932)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4868(Domain of unknown function (DUF932)),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.102(Domain of unknown function (DUF932)),Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.21(Domain of unknown function (DUF932)) b0252(CP4-6 prophage; conserved protein),b2633(CP4-57 prophage; predicted protein) Cluster67 2 2 1 1 0 1 2 ROD_19821(prophage late promoter activator protein),ROD_36491(prophage late promoter activator protein) ENC_02850(Ogr/Delta-like zinc finger.),ENC_43930(Ogr/Delta-like zinc finger.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3102(DNA-binding transcriptional regulator,Ogr/Delta-like zinc finger) b2082(positive regulator of P2 growth (insertion of P2 ogr gene into the chromosome)) t4523(bacteriophage gene regulatory protein) SL1344_2645(bacteriophage late control gene),SL1344_2717(bacteriophage gene regulatory protein) Cluster68 1 0 1 6 1 0 0 pseudoROD_48941(IS3 family transposase B (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_5_5104002-5133359.8(IS2 transposase TnpB,Integrase core domain) b0361(IS2 transposase TnpB),b1402(IS2 transposase TnpB),b1996(IS2 transposase TnpB),b2860(IS2 transposase TnpB),b3045(IS2 transposase TnpB),b4273(IS2 transposase TnpB) BN373_p01641(conserved hypothetical protein) Cluster69 1 0 1 6 1 0 0 pseudoROD_48951(IS3 family transposase A (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_5_5104002-5133359.7(IS2 repressor TnpA,Transposase) b0360(IS2 repressor TnpA),b1403(IS2 repressor TnpA),b1997(IS2 repressor TnpA),b2861(IS2 repressor TnpA),b3044(IS2 repressor TnpA),b4272(IS2 repressor TnpA) BN373_p00851(IS2 repressor TnpA) Cluster70 2 1 1 1 1 2 1 ROD_08981(phage DNA invertase),ROD_47401(phage DNA invertase) ENC_16960(Site-specific recombinases, DNA invertase Pin homologs) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3037(DNA-invertase hin,multiple promoter invertase,Resolvase, N terminal domain) b1158(e14 prophage; site-specific DNA recombinase) BN373_p00801(resolvase domain-containing protein) t2667(putative DNA-invertase),t3437(DNA-invertase) SL1344_2757(DNA-invertase hin) Cluster71 1 1 2 2 1 1 1 ROD_40191(putative permease) ENC_04020(Permeases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4805(Probable adenine permease PurP,Permeases,Permease family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4851(Putative permease yicO,Permeases,Permease family) b3664(Probable adenine permease),b3714(adenine permease, high affinity) BN373_47601(inorganic anion transporter, sulfate permease (SulP) family) t3672(putative membrane transport protein) SL1344_3818(putative membrane transport protein) Cluster72 1 1 2 2 1 1 1 ROD_42171(L-lactate permease) ENC_47720(L-lactate permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.739(Glycolate permease glcA,glycolate transporter,transporter, lactate permease (LctP) family,L-lactate permease),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.81(L-lactate permease,L-lactate permease,transporter, lactate permease (LctP) family,L-lactate permease) b2975(glycolate transporter),b3603(L-lactate permease) BN373_45891(L-lactate permease) t3827(L-lactate permease) SL1344_3657(L-lactate permease) Cluster73 1 1 2 2 1 1 1 ROD_43061(low-affinity inorganic phosphate transporter) ENC_27010(Phosphate/sulphate permeases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.206(Low-affinity inorganic phosphate transporter 1,Phosphate transporter family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.718(Low-affinity inorganic phosphate transporter 1,Phosphate transporter family) b2987(phosphate transporter),b3493(phosphate transporter, low-affinity) BN373_44941(low-affinity inorganic phosphate transporter) t3927(putative low-affinity inorganic phosphate transporter) SL1344_3554(putative low-affinity inorganic phosphate transporter) Cluster74 2 1 1 1 2 1 1 ROD_38501(alcohol dehydrogenase),ROD_42281(putative alcohol dehydrogenase) ENC_00580(lactaldehyde reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.94(Alcohol dehydrogenase 2,putative alcohol dehydrogenase,Glycerol dehydrogenase and related enzymes,lactaldehyde reductase,Iron-containing alcohol dehydrogenase) b3589(predicted Fe-containing alcohol dehydrogenase, Pfam00465 family) BN373_41441(1,3-propanediol dehydrogenase),BN373_48391(lactaldehyde reductase) t3575(alcohol dehydrogenase) SL1344_3993(alcohol dehydrogenase) Cluster75 1 2 1 2 1 1 1 ROD_29161(fimbrial subunit FimF) ENC_03030(P pilus assembly protein, pilin FimA),ENC_33310(P pilus assembly protein, pilin FimA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4079(hypothetical protein,fimbrial protein BcfF,P pilus assembly protein, pilin FimA,Fimbrial protein) b0943(predicted fimbrial-like adhesin protein),b4318(minor component of type 1 fimbriae) BN373_39231(fimbrial protein FimF) t0027(fimbrial subunit) SL1344_0026(fimbrial subunit) Cluster76 1 1 2 2 1 1 1 ROD_29141(fimbrial chaperone protein FimC) ENC_22150(P pilus assembly protein, chaperone PapD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2332(Chaperone protein focC precursor,fimbrial chaperone protein FimC,Gram-negative pili assembly chaperone, N-terminal domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4081(Chaperone protein fimC precursor,fimbrial chaperone protein FimC,Gram-negative pili assembly chaperone, N-terminal domain) b0531(pilin chaperone, periplasmic),b4316(chaperone, periplasmic) BN373_39211(chaperone protein FimC) t2318(fimbrial chaperone protein) SL1344_0538(fimbrial chaperone protein) Cluster77 1 1 2 2 1 1 1 ROD_29121(fimbrial major subunit FimA) ENC_22170(P pilus assembly protein, pilin FimA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2331(Type-1A pilin,type-1 fimbrial protein subunit A,P pilus assembly protein, pilin FimA,Fimbrial protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4083(Fimbrial subunit type 1 precursor,type-1 fimbrial protein subunit A,P pilus assembly protein, pilin FimA,Fimbrial protein) b0530(predicted fimbrial-like adhesin protein),b4314(major type 1 subunit fimbrin (pilin)) BN373_39191(type-1 fimbrial protein) t2320(Type-1 fimbrial protein, a chain precursor) SL1344_0536(type-1 fimbrial protein, a chain precursor) Cluster78 1 1 2 2 1 1 1 ROD_31251(multidrug resistance protein B) ENC_29330(drug resistance transporter, EmrB/QacA subfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1094(Multidrug resistance protein B,putative transporter,Arabinose efflux permease,drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family,Major Facilitator Superfamily),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1349(Multidrug resistance protein B,putative transporter,Arabinose efflux permease,drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family,Major Facilitator Superfamily) b2367(predicted multidrug efflux system),b2686(multidrug efflux system protein) BN373_36531(multidrug resistance protein B) t2712(multidrug resistance protein B) SL1344_2800(multidrug resistance protein B) Cluster79 0 2 2 2 1 1 1 ENC_02820(Integrase),ENC_24500(Integrase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1364(Putative prophage CPS-53 integrase,integrase,Site-specific recombinase XerD,tyrosine recombinase XerD,Phage integrase family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.18(Putative prophage CPS-53 integrase,integrase,Site-specific recombinase XerD,Phage integrase family) b2349(CPS-53 (KpLE1) prophage; predicted prophage CPS-53 integrase),b2622(CP4-57 prophage; integrase) BN373_35971(putative integrase) t2647(hypothetical protein) SL1344_2712(bacteriophage integrase) Cluster80 1 2 1 1 2 1 1 pseudoROD_49321(6-phospho-beta-glucosidase (pseudogene)) ENC_31380(6-phospho-beta-glucosidase),ENC_37830(6-phospho-beta-glucosidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.854(6-phospho-beta-glucosidase BglA,6-phospho-beta-glucosidase BglA,Beta-xylosidase,beta-galactosidase,Glycosyl hydrolase family 1) b2901(6-phospho-beta-glucosidase A) BN373_34811(putative 6-phospho-beta-glucosidase BglA),BN373_39971(6-phospho-beta-glucosidase BglA) t2969(6-phospho-beta-glucosidase) SL1344_3027(6-phospho-beta-glucosidase) Cluster81 2 2 1 1 1 1 1 ROD_28091(putative ion-channel protein),ROD_35481(putative aldo/keto reductase) ENC_32390(Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)),ENC_38580(Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.705(hypothetical protein,L-glyceraldehyde 3-phosphate reductase,Predicted oxidoreductase,voltage-dependent potassium channel beta subunit,Aldo/keto reductase family) b3001(L-glyceraldehyde 3-phosphate reductase) BN373_34051(oxidoreductase, aldo/keto reductase family) t0451(putative ion-channel protein) SL1344_2374(putative ion-channel protein) Cluster82 1 1 1 1 1 2 2 ROD_22941(fructose-specific PTS system EIIBC component) ENC_40060(PTS system D-fructose-specific IIB component (F1P-forming), Frc family (TC 4.A.2.1.1)/PTS system D-fructose-specific IIC component (F1P-forming), Frc family (TC 4.A.2.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1543(EIIBC-Fru,PTS system fructose-specific transporter subunits IIBC,PTS system, Fru family, IIC component,Phosphotransferase system, EIIC) b2167(fused fructose-specific PTS enzymes: IIBcomponent/IIC components) BN373_32021(PTS system fructose-specific EIIBC component) t0651(fructose-specific IIBC component of PTS system),t3665(probable PTS system permease) SL1344_2181(PTS system, fructose-specific IIBC component),SL1344_3825(probable PTS system permease) Cluster83 1 2 1 2 1 1 1 ROD_21971(protein-tyrosine phosphatase) ENC_02660(Protein-tyrosine-phosphatase),ENC_41060(Protein-tyrosine-phosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1651(Low molecular weight protein-tyrosine-phosphatase wzb,tyrosine phosphatase,Protein-tyrosine-phosphatase,arsenate reductase (thioredoxin),Low molecular weight phosphotyrosine protein phosphatase) b0982(phosphotyrosine-protein phosphatase),b2061(protein-tyrosine phosphatase) BN373_31141(protein tyrosine phosphatase) t0755(putative protein-tyrosine phosphatase) SL1344_2094(putative protein-tyrosine phosphatase) Cluster84 1 1 1 1 1 2 2 ROD_21851(mannose-1-phosphate guanylyltransferase) ENC_41360(mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1663(Mannose-1-phosphate guanylyltransferase 1,mannose-1-phosphate guanyltransferase,Uncharacterized conserved protein, contains double-stranded beta-helix domain,mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase,Nucleotidyl transferase) b2049(mannose-1-phosphate guanyltransferase) BN373_31021(mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase) t0767(mannose-1-phosphate guanylyltransferase),t0789(mannose-1-phosphate guanylyltransferase) SL1344_2061(mannose-1-phosphate guanylyltransferase),SL1344_2082(mannose-1-phosphate guanylyltransferase) Cluster85 1 2 1 1 2 1 1 ROD_44791(elongation factor G) ENC_09690(translation elongation factor 2 (EF-2/EF-G)),ENC_25390(translation elongation factor 2 (EF-2/EF-G)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.356(Elongation factor G,elongation factor G,GTPases - translation elongation factors,translation elongation factor G,Elongation factor Tu GTP binding domain) b3340(protein chain elongation factor EF-G, GTP-binding) BN373_30721(translation elongation factor G),BN373_43621(translation elongation factor G) t4059(elongation factor G) SL1344_3413(elongation factor G) Cluster86 1 2 1 1 2 1 1 ROD_28131(nucleoside permease) ENC_16160(Nucleoside permease),ENC_38540(nucleoside transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1324(Nucleoside-transport system protein nupC,nucleoside transporter, NupC family,Na+ dependent nucleoside transporter C-terminus) b2393(nucleoside (except guanosine) transporter) BN373_16591(Na+ dependent nucleoside transporter),BN373_34081(nucleoside transporter NupC) t0448(nucleoside permease NupC) SL1344_2377(nucleoside permease NupC) Cluster87 8 0 0 0 1 0 0 ROD_01351(ISCro5 transposase),ROD_04401(ISCro5 transposase),ROD_12201(ISCro5 transposase),ROD_23001(ISCro5 transposase),ROD_38021(ISCro5 transposase),pseudoROD_03432(putative transposase (fragment)),pseudoROD_31861(putative transposase (pseudogene)),pseudoROD_47841(putative transposase (fragment)) BN373_16121(conserved hypothetical protein) Cluster88 2 0 2 0 1 3 1 ROD_19851(phage tail tube protein),ROD_36521(phage tail tube protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3099(phage major tail tube protein,Phage tail tube protein FII),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.6(phage major tail tube protein,Phage tail tube protein FII) BN373_14861(major tail tube protein) t2665(probable major tail tube protein),t3439(probable major tail tube protein),t4300(probable major tail tube protein) SL1344_2671(probable major tail tube protein) Cluster89 2 0 2 0 1 3 1 ROD_19841(phage tail sheath protein),ROD_36511(phage tail sheath protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3100(Phage tail sheath protein),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.5(Phage tail sheath protein) BN373_14851(major tail sheath protein) t2666(putative bacteriophage major tail sheath protein),t3438(probable major tail sheath protein),t4301(probable major tail sheath protein) SL1344_2672(probable major tail sheath protein) Cluster90 1 1 1 1 2 1 2 ROD_06531(penicillin-binding protein 2) ENC_20740(peptidoglycan glycosyltransferase /cell elongation-specific peptidoglycan D,D-transpeptidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3364(Peptidoglycan synthase FtsI precursor,penicillin-binding protein 2,Membrane carboxypeptidase/penicillin-binding protein,penicillin-binding protein 2,Penicillin binding protein transpeptidase domain) b0635(transpeptidase involved in peptidoglycan synthesis (penicillin-binding protein 2)) BN373_12471(penicillin-binding protein 2),BN373_23961(penicillin-binding protein) t2227(penicillin-binding protein 2) SL1344_0628(penicillin-binding protein 2),SL1344_1845(penicillin-binding protein) Cluster91 1 1 2 2 1 1 1 ROD_05971(ferric enterobactin transport ATP-binding protein) ENC_36580(ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3410(Probable siderophore transport system ATP-binding protein YusV,iron-enterobactin transporter ATP-binding protein,ABC-type enterochelin transport system, ATPase component,proposed F420-0 ABC transporter, ATP-binding protein,ABC transporter),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4155(Probable siderophore transport system ATP-binding protein YusV,iron-dicitrate transporter ATP-binding subunit,ABC-type enterochelin transport system, ATPase component,proposed F420-0 ABC transporter, ATP-binding protein,ABC transporter) b0588(iron-enterobactin transporter subunit),b4287(KpLE2 phage-like element; iron-dicitrate transporter subunit) BN373_11841(ferric enterobactin ABC transporter, ATP-binding protein) t2278(ferric enterobactin transport ATP-binding protein FepC) SL1344_0578(ferric enterobactin transport ATP-binding protein FepC) Cluster92 1 0 2 2 2 1 1 ROD_49431(lysyl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4329(Lysine--tRNA ligase, heat inducible,lysyl-tRNA synthetase,Aspartyl/asparaginyl-tRNA synthetases,lysine--tRNA ligase,tRNA synthetases class II (D, K and N)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.865(Lysine--tRNA ligase,lysyl-tRNA synthetase,Aspartyl/asparaginyl-tRNA synthetases,lysine--tRNA ligase,tRNA synthetases class II (D, K and N)) b2890(lysine tRNA synthetase, constitutive),b4129(lysine tRNA synthetase, inducible) BN373_10661(lysyl-tRNA synthetase LysS homolog),BN373_39851(lysyl-tRNA synthetase LysS) t2958(lysyl tRNA synthetase) SL1344_3016(Lysyl-tRNA synthetase) Cluster93 1 1 2 1 2 1 1 ROD_30191(conserved hypothetical protein) ENC_03620(Predicted transcription regulator containing HTH domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1060(Antitoxin HigA,Predicted transcription regulator containing HTH domain,Helix-turn-helix domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.609(Antitoxin HigA,Predicted transcription regulator containing HTH domain,Helix-turn-helix domain) b3082(antitoxinof the HigB-HigA toxin-antitoxin system) BN373_09911(putative transcriptional regulator),BN373_10991(XRE family transcriptional regulator) t3591(conserved hypothetical protein) SL1344_3976(conserved hypothetical protein) Cluster94 1 1 1 1 2 1 2 ROD_05411(copper-transporting P-type ATPase) ENC_22440(copper-(or silver)-translocating P-type ATPase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3494(Copper-exporting P-type ATPase A,copper exporting ATPase,Uncharacterized protein conserved in bacteria,copper-translocating P-type ATPase,E1-E2 ATPase) b0484(copper transporter) BN373_09531(copper-exporting ATPase),BN373_p00661(putative cation transporting P-type ATPase (silver resistance)) t2362(copper-transporting ATPase) SL1344_0348(putative cation transport atpase (ec 3.6.1.-)),SL1344_0491(copper-transporting ATPase) Cluster95 1 2 1 1 2 1 1 ROD_01361(quinoprotein glucose dehydrogenase) ENC_12540(membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family),ENC_46400(quinoprotein glucose dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3860(Quinoprotein glucose dehydrogenase,outer membrane biogenesis protein BamB,Glucose dehydrogenase,membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family,PQQ enzyme repeat) b0124(glucose dehydrogenase) BN373_06221(quinoprotein glucose dehydrogenase),BN373_25321(quinate dehydrogenase (pyrroloquinoline-quinone)) t0174(glucose dehydrogenase) SL1344_0170(glucose dehydrogenase) Cluster96 1 1 1 1 1 2 2 ROD_06301(citrate lyase alpha chain) ENC_32170(citrate lyase, alpha subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3383(Citrate lyase alpha chain,citrate lyase, alpha subunit,Citrate lyase, alpha subunit (CitF)) b0615(citrate lyase, citrate-ACP transferase (alpha) subunit) BN373_05221(citrate lyase, alpha subunit) t0063(citrate lyase alpha chain),t2246(citrate lyase alpha chain) SL1344_0062(citrate lyase alpha chain),SL1344_0609(citrate lyase alpha chain) Cluster97 1 1 1 1 1 2 2 ROD_06311(citrate lyase beta chain) ENC_32180(citrate lyase, beta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3382(Citrate lyase subunit beta,Citrate lyase beta subunit,citrate (pro-3S)-lyase, beta subunit,HpcH/HpaI aldolase/citrate lyase family) b0616(citrate lyase, citryl-ACP lyase (beta) subunit) BN373_05211(citrate (pro-3S)-lyase, beta subunit) t0062(citrate lyase beta chain),t2245(citrate lyase beta chain) SL1344_0061(citrate lyase beta chain),SL1344_0610(citrate lyase beta chain) Cluster98 1 1 1 1 1 2 2 ROD_06331(citrate (pro-3S)-lyase] ligase) ENC_32200([citrate (pro-3S)-lyase] ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3380([Citrate [pro-3S]-lyase] ligase,[citrate (pro-3S)-lyase] ligase,Citrate lyase ligase C-terminal domain) b0618([citrate [pro-3S]-lyase] ligase) BN373_05191([citrate (pro-3S)-lyase] ligase) t0060([citrate (PRO-3S)-lyase] ligase),t2243([citrate (pro-3S)-lyase] ligase) SL1344_0059([citrate (PRO-3S)-lyase] ligase),SL1344_0612([citrate (pro-3S)-lyase] ligase) Cluster99 3 0 1 2 1 1 1 ROD_07081(conserved hypothetical protein),ROD_26571(putative transposase),ROD_44121(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1465(hypothetical protein,conserved hypothetical protein,Putative transposase, YhgA-like) b2244(conserved protein),b2305(conserved protein) BN373_03961(conserved hypothetical protein) t3998(conserved hypothetical protein) SL1344_3475(conserved hypothetical protein) Cluster100 1 1 1 1 1 2 2 ROD_33131(Mg(2+) transport ATPase, P-type) ENC_43680(magnesium-translocating P-type ATPase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4207(Magnesium-transporting ATPase, P-type 1,magnesium-transporting ATPase MgtA,Uncharacterized protein conserved in bacteria,magnesium-translocating P-type ATPase,E1-E2 ATPase) b4242(magnesium transporter) BN373_02651(magnesium-translocating P-type ATPase) t3755(Magnesium transport ATPase, P-type 2),t4491(Mg(2+) transport ATPase, P-type) SL1344_3728(Magnesium transport ATPase, P-type 2),SL1344_4387(Mg(2+) transport ATPase, P-type) Cluster101 2 1 1 1 2 1 1 ROD_33911(formate dehydrogenase H (FDH-H)),ROD_34681(formate dehydrogenase H alph subunit (formate-hydrogen-lyase-linked selenocysteine-containing polypeptide)) ENC_05080(formate dehydrogenase alpha subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4388(Formate dehydrogenase H,nitrate reductase catalytic subunit,Uncharacterized anaerobic dehydrogenase,formate dehydrogenase, alpha subunit,Molybdopterin oxidoreductase) b4079(formate dehydrogenase-H, selenopolypeptide subunit) BN373_00931(formate dehydrogenase H, alpha subunit, selenocysteine-containing),BN373_26751(formate dehydrogenase, alpha subunit) t4192(formate dehydrogenase H) SL1344_4221(putative formate dehydrogenase H) Cluster102 1 1 2 2 1 1 1 ROD_34501(putative permease) ENC_04980(Permeases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4410(Putative permease yjcD,Permeases,Permease family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.871(Putative permease yjcD,Permeases,Permease family) b4064(predicted permease),b4464(predicted purine permease) BN373_00741(inorganic anion transporter, sulfate permease (SulP) family) t4174(putative xanthine/uracil permeases family protein) SL1344_4204(putative xanthine/uracil permeases family protein) Cluster103 1 1 4 2 0 0 0 ROD_49711(putative antirestriction protein) ENC_35800(Antirestriction protein.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1714(Antirestriction protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4130(Antirestriction protein),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.118(Antirestriction protein),Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.20(Antirestriction protein) b0248(CP4-6 prophage; predicted protein),b2643(CP4-57 prophage; predicted antirestriction protein) Cluster104 2 1 2 2 0 0 1 ROD_28011(multiphosphoryl transfer protein 1 [includes phosphoenolpyruvate-protein phosphotransferase; phosphocarrier protein Hp; fructose-like phosphotransferase enzyme IIA component]),ROD_37971(multiphosphoryl transfer protein 2) ENC_21030(Phosphocarrier protein HPr/phosphoenolpyruvate--protein phosphotransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1333(Multiphosphoryl transfer protein 1,phosphoenolpyruvate-protein phosphotransferase,Uncharacterized protein conserved in bacteria,phosphoenolpyruvate-protein phosphotransferase,PEP-utilising enzyme, TIM barrel domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4553(Multiphosphoryl transfer protein 1,phosphoenolpyruvate-protein phosphotransferase,Uncharacterized protein conserved in bacteria,phosphoenolpyruvate-protein phosphotransferase,PEP-utilising enzyme, TIM barrel domain) b2383(fused predicted PTS enzymes: Hpr component/enzyme I component/enzyme IIA component),b3947(fused predicted PTS enzymes: Hpr component/enzyme I component/enzyme IIA component) SL1344_4060(phosphoenolpyruvate-protein phosphotransferase (ec 2.7.3.9) (phosphotransferase system, enzyme i) (enzyme i-ani)) Cluster105 1 2 1 1 0 2 1 ROD_30071(putative LEE-encoded exported protein) ENC_18210(Transglycosylase SLT domain.),ENC_36100(Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.101(lytic transglycosylase,Transglycosylase SLT domain) pseudob2854(unknown) t2779(cell invasion protein),t4248(putative membrane protein) SL1344_2857(cell invasion protein) Cluster106 1 2 2 1 0 1 1 pseudoROD_03091(lateral flagellar rod protein (pseudogene)) ENC_15660(fagellar hook-basal body proteins),ENC_28440(fagellar hook-basal body proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2839(Putative proximal rod protein,flagellar basal body rod protein FlgF,Flagellar basal body rod protein,flagellar hook-basal body protein,Domain of unknown function (DUF1078)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3726(Putative proximal rod protein,flagellar basal body rod protein FlgF,Flagellar basal body rod protein,flagellar basal-body rod protein FlgF,Domain of unknown function (DUF1078)) b1077(flagellar component of cell-proximal portion of basal-body rod) t1742(putative flagellar basal-body rod protein FlgF) SL1344_1115(putative flagellar basal-body rod protein FlgF (proximal rod protein)) Cluster107 1 2 2 1 0 1 1 ROD_03111(lateral flagellar rod protein) ENC_15650(flagellar basal-body rod protein FlgG, Gram-negative bacteria),ENC_28430(flagellar basal-body rod protein FlgG, Gram-negative bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2838(Distal rod protein,flagellar basal body rod protein FlgG,Flagellar basal body rod protein,flagellar basal-body rod protein FlgG,Domain of unknown function (DUF1078)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3725(Distal rod protein,flagellar basal body rod protein FlgG,Flagellar basal body rod protein,flagellar basal-body rod protein FlgG,Domain of unknown function (DUF1078)) b1078(flagellar component of cell-distal portion of basal-body rod) t1741(flagellar basal-body rod protein FlgG) SL1344_1116(flagellar basal-body rod protein FlgG (distal rod protein)) Cluster108 4 2 0 0 0 1 1 ROD_08951(putative ATP-binding protein of T1SS),ROD_25721(putative ATP-binding protein of T1SS),ROD_29601(putative ATP-binding protein of T1SS),ROD_48181(putative ATP-binding protein of T1SS) ENC_11250(type I secretion system ATPase, LssB family),ENC_29000(type I secretion system ATPase, LssB family) t2645(putative type I secretion protein, ATP-binding protein) SL1344_2663(putative type I secretion protein, ATP-binding protein) Cluster109 1 2 1 2 0 1 1 ROD_37211(putative lipoprotein) ENC_02680(Bacterial putative lipoprotein (DUF940).),ENC_04600(Bacterial putative lipoprotein (DUF940).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4458(Bacterial putative lipoprotein (DUF940)) b0984(conserved protein),b4029(predicted porin) t4131(putative lipoprotein) SL1344_4161(putative lipoprotein) Cluster110 1 1 1 1 2 1 1 ROD_50441(two-component response regulator) ENC_35360(Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1856(Probable transcriptional regulatory protein YedW,transcriptional regulatory protein YedW,Response regulator of citrate/malate metabolism,heavy metal response regulator,Response regulator receiver domain) b1969(predicted DNA-binding response regulator in two-component system with YedV) BN373_p00591(DNA-binding transcriptional activator CusR),BN373_p00751(Transcriptional regulatory protein pcoR) t1823(response regulator) SL1344_1035(response regulator) Cluster111 1 0 0 5 1 0 1 ROD_49861(IS3 transposase A) b0298(IS3 transposase A),b0373(IS3 transposase A),b0540(IS3 transposase A),b1027(IS3 transposase A),b2088(IS3 transposase A) BN373_p00191(conserved hypothetical protein) SL1344_2753(IS3 transposase) Cluster112 0 2 1 0 1 2 2 ENC_41750(5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases),ENC_41760(5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4560(Trifunctional nucleotide phosphoesterase protein YfkN precursor,bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein,NAD nucleotidase,5'-nucleotidase, C-terminal domain) BN373_48691(putative 5'-nucleotidase/2',3'-cyclic phosphodiesterase) t0035(putative secreted 5'-nucleotidase),t3515(hypothetical protein) SL1344_0034(putative secreted 5'-nucleotidase),SL1344_4054(conserved hypothetical protein) Cluster113 1 1 1 1 2 1 1 ROD_42741(cellulose synthase catalytic subunit [UDP-forming]) ENC_27310(cellulose synthase catalytic subunit (UDP-forming)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.157(Cellulose synthase catalytic subunit [UDP-forming],cellulose synthase catalytic subunit,Predicted glycosyl hydrolase,cellulose synthase catalytic subunit (UDP-forming),Glycosyl transferase family 2) b3533(cellulose synthase, catalytic subunit) BN373_45201(cellulose synthase (UDP-forming)),BN373_45301(putative cellulose synthase (UDP-forming)) t3898(putative catalytic subunit of a polysaccharide biosynthesis protein) SL1344_3584(putative polysaccharide biosynthesis protein catalytic subunit) Cluster114 1 1 1 1 2 1 1 ROD_45351(polypeptide deformylase) ENC_25010(peptide deformylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.410(Peptide deformylase,peptide deformylase,N-formylmethionyl-tRNA deformylase,peptide deformylase,Polypeptide deformylase) b3287(peptide deformylase) BN373_43231(peptide deformylase),BN373_p00381(peptide deformylase) t4098(polypeptide deformylase) SL1344_3373(polypeptide deformylase) Cluster115 1 1 1 1 1 1 2 ROD_45991(putative N-acetylmannosamine-6-phosphate 2-epimerase) ENC_30190(Putative N-acetylmannosamine-6-phosphate epimerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.476(Putative N-acetylmannosamine-6-phosphate 2-epimerase,N-acetylmannosamine-6-phosphate 2-epimerase,Putative N-acetylmannosamine-6-phosphate epimerase) b3223(predicted N-acetylmannosamine-6-P epimerase) BN373_42761(N-acetylmannosamine-6-phosphate 2-epimerase) t1791(conserved hypothetical protein) SL1344_1067(conserved hypothetical protein),SL1344_3309(putative N-acetylmannosamine-6-phosphate 2-epimerase 2 (ec 5.1.3.9) (mannac-6-p epimerase 2)) Cluster116 1 1 2 1 1 1 1 pseudoROD_47941(hexuronate transporter (pseudogene)) ENC_33500(d-galactonate transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4249(Hexuronate transporter,regulatory protein UhpC,Arabinose efflux permease,D-galactonate transporter,Major Facilitator Superfamily),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.597(Hexuronate transporter,sugar phosphate antiporter,Arabinose efflux permease,D-galactonate transporter,Major Facilitator Superfamily) b3093(hexuronate transporter) BN373_41841(hexuronate transporter) t3055(hexuronate transporter) SL1344_3108(hexuronate transporter) Cluster117 2 1 1 1 1 1 1 ROD_35561(cystathionine beta-lyase),ROD_48281(cystathionine beta-lyase) ENC_32460(cystathionine beta-lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.700(Cystathionine beta-lyase metC,cystathionine beta-lyase,cystathionine beta-lyase,Cys/Met metabolism PLP-dependent enzyme) b3008(cystathionine beta-lyase, PLP-dependent) BN373_40801(cystathionine beta-lyase) t3081(beta-cystathionase) SL1344_3135(beta-cystathionase) Cluster118 1 1 1 2 1 1 1 ROD_30901(formate hydrogenlyase subunit 5) ENC_29740(Ni,Fe-hydrogenase III large subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1055(Hydrogenase-3 component E,NADH dehydrogenase subunit D,Ni,Fe-hydrogenase III component G,NADH dehydrogenase (quinone), D subunit,Respiratory-chain NADH dehydrogenase, 30 Kd subunit) b2487(hydrogenase 4, subunit),b2721(hydrogenase 3, large subunit) BN373_36911(formate hydrogenlyase, subunit E) t2751(formate hydrogenlyase subunit 5) SL1344_2829(formate hydrogenlyase subunit 5) Cluster119 0 1 3 1 1 0 2 ENC_17090(phage tail tape measure protein, lambda family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1837(Phage-related minor tail protein,phage tail tape measure protein, lambda family,Tail length tape measure protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2533(Phage-related minor tail protein,phage tail tape measure protein, lambda family,Tail length tape measure protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2737(Phage-related minor tail protein,phage tail tape measure protein, lambda family,Prophage tail length tape measure protein) pseudob1368(unknown) BN373_33481(lambda family phage tail tape measure protein) SL1344_0980(Tape Measure),SL1344_2558(predicted bacteriophage protein) Cluster120 1 1 1 2 1 1 1 ROD_22971(sugar efflux transporter B) ENC_40030(sugar efflux transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1540(Sugar efflux transporter B,sugar efflux transporter B,Arabinose efflux permease,sugar efflux transporter,Major Facilitator Superfamily) b2170(lactose/glucose efflux system),b3659(predicted sugar efflux system) BN373_32051(sugar efflux transporter B) t0648(sugar efflux transporter) SL1344_2184(sugar efflux transporter) Cluster121 1 2 1 1 1 1 1 ROD_22611(multidrug resistance outer membrane protein) ENC_40270(Outer membrane protein),ENC_40280(Outer membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1570(Multidrug resistance outer membrane protein MdtP precursor,multidrug resistance outer membrane protein MdtQ,efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family,Outer membrane efflux protein) pseudob2139(unknown) BN373_31781(efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family) t0683(putative lipoprotein) SL1344_2150(putative lipoprotein) Cluster122 1 1 1 1 2 1 1 ROD_44211(phosphoenolpyruvate carboxykinase [ATP]) ENC_26030(phosphoenolpyruvate carboxykinase (ATP)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.297(Phosphoenolpyruvate carboxykinase [ATP],phosphoenolpyruvate carboxykinase,Phosphoenolpyruvate carboxykinase (ATP),phosphoenolpyruvate carboxykinase (ATP),Phosphoenolpyruvate carboxykinase) b3403(phosphoenolpyruvate carboxykinase) BN373_28641(putative phosphoenolpyruvate carboxykinase (ATP)),BN373_44111(phosphoenolpyruvate carboxykinase (ATP)) t4006(phosphoenolpyruvate carboxykinase) SL1344_3467(phosphoenolpyruvate carboxykinase) Cluster123 2 1 1 1 1 1 1 ROD_08021(alcohol dehydrogenase),ROD_17681(aldehyde-alcohol dehydrogenase [includes: alcohol dehydrogenase; acetaldehyde dehydrogenase [acetylating]]) ENC_07970(acetaldehyde dehydrogenase /alcohol dehydrogenase AdhE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2599(Aldehyde-alcohol dehydrogenase,bifunctional acetaldehyde-CoA/alcohol dehydrogenase,Glycerol dehydrogenase and related enzymes,acetaldehyde dehydrogenase (acetylating),Iron-containing alcohol dehydrogenase) b1241(fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase) BN373_27951(aldehyde-alcohol dehydrogenase) t1660(alcohol dehydrogenase) SL1344_1680(alcohol dehydrogenase) Cluster124 1 0 1 1 1 2 2 ROD_23321(heme exporter ATP-binding protein (cytochrome C-type biogenesis protein)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1508(Cytochrome c biogenesis ATP-binding export protein CcmA,cytochrome c biogenesis protein CcmA,ABC-type transport system involved in cytochrome c biogenesis, ATPase component,heme ABC exporter, ATP-binding protein CcmA,ABC transporter) b2201(heme exporter subunit) BN373_26661(heme ABC exporter, ATP-binding protein CcmA) t0610(heme exporter protein A1),t3699(heme exporter protein A2) SL1344_2224(protoheme transport protein),SL1344_3785(protoheme exporter protein 1A) Cluster125 1 0 1 1 1 2 2 ROD_23311(heme exporter protein B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1509(Cytochrome c-type biogenesis protein CcmB,heme exporter protein CcmB,CcmB protein) b2200(heme exporter subunit) BN373_26651(heme exporter protein B) t0611(heme exporter protein B1),t3700(heme exporter protein B2) SL1344_2223F(protoheme transport protein B2),SL1344_3784(protoheme transport protein B1 (cytochrome c-type biogenesis protein ccmB1)) Cluster126 1 0 1 1 1 2 2 ROD_23301(heme exporter protein C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1510(Cytochrome c-type biogenesis protein CcmC,heme exporter protein CcmC,Cytochrome C assembly protein) b2199(heme exporter subunit) BN373_26641(heme exporter protein C) t0612(heme exporter protein C1),t3701(heme exporter protein C2) SL1344_2223E(protoheme transport protein),SL1344_3783(protoheme transport protein C1 (cytochrome c-type biogenesis protein ccmc1)) Cluster127 1 0 1 1 1 2 2 ROD_23271(cytochrome C-type biogenesis protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1513(Cytochrome c-type biogenesis protein CcmF,heme lyase subunit NrfE,Uncharacterized protein involved in biosynthesis of c-type cytochromes,cytochrome c-type biogenesis protein CcmF,Cytochrome C assembly protein) b2196(heme lyase, CcmF subunit) BN373_26611(cytochrome c-type biogenesis protein CcmF) t0615(cytochrome c-type biogenesis protein F1),t3704(cytochrome c-type biogenesis protein F2) SL1344_2223B(cytochrome C-type biogenesis protein),SL1344_3781(cytochrome C-type biogenesis protein) Cluster128 1 0 1 1 1 2 2 ROD_23261(thiol:disulfide interchange protein (cytochrome C-type biogenesis protein)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1514(Cytochrome c biogenesis protein CcmG,thiol:disulfide interchange protein DsbE,Thiol:disulfide interchange protein,periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily,Redoxin) b2195(periplasmic thioredoxin of cytochrome c-type biogenesis) BN373_26601(thiol:disulfide interchange protein DsbE) t0616(thiol:disulfide interchange protein),t3705(thiol:disulfide interchange protein) SL1344_2223A(cytochrome C-type biogenesis protein),SL1344_3780(cytochrome C-type biogenesis protein) Cluster129 1 0 1 1 1 2 2 ROD_23251(cytochrome C-type biogenesis protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1515(Cytochrome c-type biogenesis protein CcmH precursor,formate-dependent nitrite reductase complex subunit NrfF,Cytochrome c biogenesis factor,cytochrome c nitrite reductase, accessory protein NrfF,Cytochrome C biogenesis protein) b2194(heme lyase, CcmH subunit) BN373_26596(unknown) t0617(cytochrome c-type biogenesis protein H1),t3706(cytochrome c-type biogenesis protein H2) SL1344_2223(cytochrome C-type biogenesis protein H2),SL1344_3779(cytochrome c-type biogenesis protein H1) Cluster130 1 1 1 2 1 1 1 ROD_00381(carnitinyl-CoA dehydratase) ENC_11660(Enoyl-CoA hydratase/carnithine racemase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3957(Carnitinyl-CoA dehydratase,carnitinyl-CoA dehydratase,phenylacetate degradation probable enoyl-CoA hydratase PaaB,Enoyl-CoA hydratase/isomerase family) b0036(carnitinyl-CoA dehydratase),b1393(2,3-dehydroadipyl-CoA hydratase) BN373_20291(enoyl-CoA hydratase PaaF) t0071(carnitine racemase) SL1344_0071(carnitine racemase) Cluster131 2 1 3 0 2 0 0 ROD_28191(putative Rhs protein),pseudoROD_35341(putative Rhs protein (pseudogene)) ENC_08970(type VI secretion system Vgr family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.943(Uncharacterized protein conserved in bacteria,Rhs element Vgr protein,Uncharacterized protein conserved in bacteria (DUF2345)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.947(Uncharacterized protein conserved in bacteria,Rhs element Vgr protein,Uncharacterized protein conserved in bacteria (DUF2345)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.950(Uncharacterized protein conserved in bacteria,Rhs element Vgr protein,Uncharacterized protein conserved in bacteria (DUF2345)) BN373_19561(type VI secretion system Vgr family protein),BN373_28511(type VI secretion system Vgr family protein) Cluster132 1 1 2 1 1 1 1 ROD_17361(ribosomal large subunit pseudouridine synthase B) ENC_08280(ribosomal large subunit pseudouridine synthase B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2500(Ribosomal large subunit pseudouridine synthase B,23S rRNA pseudouridylate synthase B,pseudouridine synthase,RNA pseudouridylate synthase),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.34(Ribosomal large subunit pseudouridine synthase B,23S rRNA pseudouridylate synthase B,pseudouridine synthase,RNA pseudouridylate synthase) b1269(23S rRNA pseudouridylate synthase) BN373_18881(ribosomal large subunit pseudouridine synthase B) t1632(putative pseudouridine synthase) SL1344_1651(putative pseudouridine synthase) Cluster133 1 1 1 1 2 1 1 ROD_28531(glycine cleavage system transcriptional activator) ENC_42530(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.967(Gcv operon activator,DNA-binding transcriptional activator GcvA,ABC-type uncharacterized transport system, periplasmic component,putative choline sulfate-utilization transcription factor,LysR substrate binding domain) b2808(DNA-binding transcriptional dual regulator) BN373_18871(transcriptional regulator, LysR family),BN373_38061(glycine cleavage system transcriptional activator) t2890(regulatory protein of glycine cleavage pathway) SL1344_2962(regulatory protein for glycine cleavage pathway) Cluster134 1 1 2 1 1 1 1 ROD_17391(anthranilate synthase component I) ENC_08250(anthranilate synthase, component I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2505(Anthranilate synthase component 1,anthranilate synthase component I,Anthranilate/para-aminobenzoate synthases component I,anthranilate synthase component I,chorismate binding enzyme),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.28(Anthranilate synthase component 1,anthranilate synthase component I,Anthranilate/para-aminobenzoate synthases component I,anthranilate synthase component I,chorismate binding enzyme) b1264(component I of anthranilate synthase) BN373_18831(anthranilate synthase, component I) t1635(anthranilate synthase component I) SL1344_1654(anthranilate synthase component I) Cluster135 1 1 2 1 1 1 1 ROD_17401(anthranilate synthase component II) ENC_08240(anthranilate synthase, component II /anthranilate phosphoribosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2506(Anthranilate synthase component II,bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase,Phosphoribosylanthranilate isomerase,glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase,Glutamine amidotransferase class-I),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.27(Anthranilate synthase component II,bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase,Phosphoribosylanthranilate isomerase,anthranilate phosphoribosyltransferase,Glycosyl transferase family, a/b domain) b1263(fused glutamine amidotransferase (component II) of anthranilate synthase/anthranilate phosphoribosyl transferase) BN373_18821(anthranilate synthase, component II) t1636(anthranilate synthase component II) SL1344_1655(Anthranilate phosphoribosyltransferase) Cluster136 1 1 2 1 1 1 1 ROD_17411(tryptophan biosynthesis protein) ENC_08230(phosphoribosylanthranilate isomerase /indole-3-glycerol phosphate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2509(Tryptophan biosynthesis protein TrpCF,bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase,Phosphoribosylanthranilate isomerase,N-(5'phosphoribosyl)anthranilate (PRA) isomerase),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.26(Tryptophan biosynthesis protein TrpCF,bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase,Phosphoribosylanthranilate isomerase,Indole-3-glycerol phosphate synthase) b1262(fused indole-3-glycerolphosphate synthetase/N-(5-phosphoribosyl)anthranilate isomerase) BN373_18811(tryptophan biosynthesis protein trpCF) t1637(indole-3-glycerol phosphate synthase) SL1344_1656(Indole-3-glycerol phosphate synthase) Cluster137 1 1 2 1 1 1 1 ROD_17421(tryptophan synthase beta chain) ENC_08210(Tryptophan synthase beta chain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2510(Tryptophan synthase beta chain,tryptophan synthase subunit beta,Tryptophan synthase alpha chain,tryptophan synthase, beta subunit,Pyridoxal-phosphate dependent enzyme),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.25(Tryptophan synthase beta chain,tryptophan synthase subunit beta,Tryptophan synthase alpha chain,tryptophan synthase, beta subunit,Pyridoxal-phosphate dependent enzyme) b1261(tryptophan synthase, beta subunit) BN373_18801(tryptophan synthase, beta subunit) t1638(tryptophan synthase beta chain) SL1344_1657(tryptophan synthase beta chain) Cluster138 1 1 2 1 1 1 1 ROD_17431(tryptophan synthase alpha chain) ENC_08200(tryptophan synthase, alpha chain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2511(Tryptophan synthase alpha chain,tryptophan synthase subunit alpha,Tryptophan synthase alpha chain,tryptophan synthase, alpha subunit,Tryptophan synthase alpha chain),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.24(Tryptophan synthase alpha chain,tryptophan synthase subunit alpha,Tryptophan synthase alpha chain,tryptophan synthase, alpha subunit,Tryptophan synthase alpha chain) b1260(tryptophan synthase, alpha subunit) BN373_18791(tryptophan synthase, alpha subunit) t1639(tryptophan synthase alpha chain) SL1344_1658(Tryptophan synthase alpha chain) Cluster139 2 1 1 1 1 1 1 ROD_07501(6-phospho-beta-glucosidase),ROD_13221(6-phospho-beta-glucosidase) ENC_14340(6-phospho-beta-glucosidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2146(6-phospho-beta-glucosidase,alpha-galactosidase,Fa mily 4 glycosyl hydrolase) b1734(phospho-chitobiase; general 6-phospho-beta-glucosidase activity) BN373_18571(6-phospho-beta-glucosidase) t1195(phospho-beta-glucosidase B) SL1344_1251(phospho-beta-glucosidase B) Cluster140 2 1 1 1 1 1 1 ROD_07481(N,N'-diacetylchitobiose permease IIC component (PTS system N,N'-diacetylchitobiose-specific EIIC component)),ROD_13191(N,N'-diacetylchitobiose-specific PTS system, EIIC component) ENC_14370(PTS system N,N'-diacetylchitobiose-specific IIC component, Lac family (TC 4.A.3.2.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2143(PTS system N,N'-diacetylchitobiose-specific EIIC component,PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC,Phosphotransferase system cellobiose-specific component IIC,PTS system, cellobiose-specific IIC component,Phosphotransferase system, EIIC) b1737(N,N'-diacetylchitobiose-specific enzyme IIC component of PTS) BN373_18541(PTS system, N,N'-diacetylchitobiose-specific EIIC component) t1192(cellobiose-specific IIC component of PTS system) SL1344_1248(PTS system, cellobiose-specific IIC component) Cluster141 1 1 1 1 1 2 1 ROD_12511(SOS mutagenesis and repair protein) ENC_35710(Nucleotidyltransferase/DNA polymerase involved in DNA repair) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2699(hypothetical protein,DNA polymerase V subunit UmuC,Nucleotidyltransferase/DNA polymerase involved in DNA repair,impB/mucB/samB family) b1184(DNA polymerase V, subunit C) BN373_18061(DNA polymerase V subunit UmuC) t0881(UmuC protein),t4291(UV protection protein) SL1344_1925(DNA repair protein) Cluster142 0 1 4 0 1 0 2 ENC_17030(Phage-related protein, tail component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1842(Fibronectin type III protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2528(Fibronectin type III protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2732(Fibronectin type III protein),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.4(hypothetical protein) BN373_17641(conserved hypothetical protein) SL1344_0987(putative Host Specificity Protein),SL1344_2553(predicted bacteriophage protein) Cluster143 1 1 2 1 1 1 1 ROD_07231(2-oxoglutarate dehydrogenase E1 component) ENC_20130(2-oxoglutarate dehydrogenase E1 component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3274(2-oxoglutarate dehydrogenase E1 component,2-oxoglutarate dehydrogenase E1 component,oxoglutarate dehydrogenase (succinyl-transferring), E1 component,Transketolase, pyrimidine binding domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4428(2-oxoglutarate dehydrogenase E1 component,2-oxoglutarate dehydrogenase E1 component,oxoglutarate dehydrogenase (succinyl-transferring), E1 component,Transketolase, pyrimidine binding domain) b0726(2-oxoglutarate decarboxylase, thiamin-requiring) BN373_13051(oxoglutarate dehydrogenase (succinyl-transferring), E1 component) t2140(2-oxoglutarate dehydrogenase E1 component) SL1344_0718(2-oxoglutarate dehydrogenase E1 component) Cluster144 1 1 1 1 2 1 1 ROD_06221(universal stress protein G) ENC_11990(Universal stress protein UspA and related nucleotide-binding proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3390(Universal stress protein G,universal stress protein UspG,Universal stress protein family) b0607(universal stress protein UP12) BN373_12311(universal stress protein G),BN373_21451(universal stress family protein) t2253(conserved hypothetical protein) SL1344_0602(conserved hypothetical protein) Cluster145 1 2 1 1 1 1 1 ROD_22231(major facilitator superfamily protein) ENC_22020(Nucleoside H+ symporter.),ENC_40630(nucleoside transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1616(Putative nucleoside transporter yegT,putative 3-phenylpropionic acid transporter,nucleoside transporter,Nucleoside H+ symporter) b2098(nucleoside transporter, low affinity) BN373_11081(nucleoside transporter) t0714(putative nucleoside permease) SL1344_2119(putative nucleoside permease) Cluster146 1 1 1 1 2 1 1 ROD_11131(lipid A biosynthesis lauroyl acyltransferase) ENC_15870(lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2862(Lipid A biosynthesis lauroyl acyltransferase,lipid A biosynthesis lauroyl acyltransferase,Lauroyl/myristoyl acyltransferase,lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase,Bacterial lipid A biosynthesis acyltransferase) b1054(lauryl-acyl carrier protein (ACP)-dependent acyltransferase) BN373_10601(lipid A biosynthesis lauroyl acyltransferase),BN373_16821(lipid A biosynthesis lauroyl acyltransferase) t1765(lipid A biosynthesis lauroyl acyltransferase) SL1344_1092(lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) (heat shock protein)) Cluster147 1 1 1 1 2 1 1 ROD_07181(citrate synthase) ENC_20180(citrate synthase I (hexameric type)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3280(Citrate synthase,type II citrate synthase,citrate (Si)-synthase,Citrate synthase) b0720(citrate synthase) BN373_10531(putative citrate (Si)-synthase),BN373_13001(citrate (Si)-synthase) t2146(citrate synthase) SL1344_0712(citrate synthase) Cluster148 1 1 1 1 2 1 1 ROD_45581(biotin carboxylase (acetyl-CoA carboxylase subunit A)) ENC_35050(Biotin carboxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.446(Biotin carboxylase,acetyl-CoA carboxylase biotin carboxylase subunit,Acetyl/propionyl-CoA carboxylase, alpha subunit,acetyl-CoA carboxylase, biotin carboxylase subunit,Carbamoyl-phosphate synthase L chain, ATP binding domain) b3256(acetyl-CoA carboxylase, biotin carboxylase subunit) BN373_07531(acetyl-CoA carboxylase biotin carboxylase subunit),BN373_43061(acetyl-CoA carboxylase, biotin carboxylase) t3295(biotin carboxylase) SL1344_3353(biotin carboxylase) Cluster149 1 1 1 1 1 2 1 ROD_34051(putative DNA methyltransferase) ENC_24060(Methyltransferase domain.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4096(hypothetical protein,hypothetical protein,Trans-aconitate methyltransferase,biotin biosynthesis protein BioC,Methyltransferase domain) b4306(KpLE2 phage-like element; predicted methyltransferase) BN373_07441(putative methyltransferase) t4343(conserved hypothetical protein),t4550(conserved hypothetical protein) SL1344_4430(conserved hypothetical protein) Cluster150 1 1 1 1 1 2 1 ROD_34071(conserved hypothetical protein) ENC_24050(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4094(hypothetical protein,Uncharacterized protein conserved in bacteria,Uncharacterized protein conserved in bacteria (DUF2084)) b4566(conserved protein) BN373_07431(conserved hypothetical protein) t4341(hypothetical protein),t4551(hypothetical protein) SL1344_4431(hypothetical protein) Cluster151 1 1 1 1 2 1 1 ROD_45761(succinate-semialdehyde dehydrogenase [NADP+]) ENC_34840(succinate semialdehyde dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1118(Succinate-semialdehyde dehydrogenase [NADP(+)] GabD,succinate-semialdehyde dehydrogenase I,Delta 1-pyrroline-5-carboxylate dehydrogenase,succinate-semialdehyde dehydrogenase,Aldehyde dehydrogenase family) b2661(succinate-semialdehyde dehydrogenase I, NADP-dependent) BN373_07401(succinate-semialdehyde dehydrogenase (NAD(P)(+))),BN373_16251(putative succinate-semialdehyde dehydrogenase (NAD(P)(+))) t2686(succinate-semialdehyde dehydrogenase) SL1344_2775(succinate-semialdehyde dehydrogenase) Cluster152 2 1 1 1 1 1 1 ROD_46381(putative phosphoglycerol transferase),ROD_48581(phosphoglycerol transferase I) ENC_44770(phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4040(phosphoglycerol transferase I,Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily,Sulfatase) b4359(phosphoglycerol transferases I and II) BN373_04371(phosphoglycerol transferase I) t4584(putative phosphoglycerol transferase) SL1344_4472(putative phosphoglycerol transferase) Cluster153 1 2 1 1 2 0 1 ROD_35101(cation efflux system protein) ENC_19010(efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family),ENC_35510(efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3438(Cation efflux system protein CusC precursor,copper/silver efflux system outer membrane protein CusC,efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family,Outer membrane efflux protein) b0572(copper/silver efflux system, outer membrane component) BN373_03641(cation efflux system protein CusC),BN373_p00611(copper/silver efflux system outer membrane protein CusC) SL1344_0345(putative outer membrane efflux lipoprotein) Cluster154 1 1 1 1 2 1 1 ROD_42411(D-xylose isomerase) ENC_47340(D-xylose isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.119(Xylose isomerase,xylose isomerase,Predicted sugar isomerase,xylose isomerase,Xylose isomerase-like TIM barrel) b3565(D-xylose isomerase) BN373_03471(xylose isomerase),BN373_45721(xylose isomerase) t3858(D-xylose isomerase) SL1344_3626(D-xylose isomerase) Cluster155 6 0 1 0 1 0 0 ROD_05761(ISEc14 transposase B),ROD_16531(ISEc14 transposase B),ROD_26371(ISEc14 transposase B),ROD_29651(ISEc14 transposase B),ROD_33831(ISEc14 transposase B),ROD_48771(ISEc14 transposase B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2646(IS2 transposase TnpB,Integrase core domain) BN373_03211(integrase catalytic region) Cluster156 6 0 1 0 1 0 0 ROD_05771(ISEc14 transposase A),ROD_16521(ISEc14 transposase A),ROD_26361(ISEc14 transposase A),ROD_29661(ISEc14 transposase A),ROD_33821(ISEc14 transposase A),ROD_48781(ISEc14 transposase A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2645(Transposase) BN373_03201(ISEc14 transposase A) Cluster157 1 1 1 2 1 1 1 ROD_33201(ornithine carbamoyltransferase subunit I) ENC_43850(ornithine carbamoyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4197(Ornithine carbamoyltransferase chain I,ornithine carbamoyltransferase subunit F,Ornithine carbamoyltransferase,ornithine carbamoyltransferase,Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain) b0273(ornithine carbamoyltransferase 2, chain F; CP4-6 prophage),b4254(ornithine carbamoyltransferase 1) BN373_02761(ornithine carbamoyltransferase) t4503(ornithine carbamoyltransferase) SL1344_4399(ornithine carbamoyltransferase) Cluster158 1 1 1 1 2 1 1 ROD_01801(outer membrane protein assembly factor) ENC_47000(outer membrane protein assembly complex, YaeT protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3802(Omp85,outer membrane protein assembly factor YaeT,Outer membrane protein/protective antigen OMA87,outer membrane protein assembly complex, YaeT protein,Surface antigen) b0177(outer membrane protein assembly factor, forms pores; required for OM biogenesis; in BamABCDE OM protein complex) BN373_00601(outer membrane protein, OMP85 family),BN373_06821(outer membrane protein assembly complex, YaeT protein) t0225(outer membrane protein precursor) SL1344_0225(outer membrane protein precursor) Cluster159 1 0 6 0 0 0 0 ROD_41301(putative adhesin autotransporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4332(Serine protease espC precursor,Type V secretory pathway, adhesin AidA,outer membrane autotransporter barrel domain,Immunoglobulin A1 protease),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4336(Temperature-sensitive hemagglutinin tsh autotransporter precursor,Type V secretory pathway, adhesin AidA,outer membrane autotransporter barrel domain,Immunoglobulin A1 protease),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.759(Serine protease sat autotransporter precursor,Type V secretory pathway, adhesin AidA,Immunoglobulin A1 protease),Escherichia_coli_UPEC_ST131_v0.1_5_5104002-5133359.21(Serine protease sat autotransporter precursor,Type V secretory pathway, adhesin AidA,outer membrane autotransporter barrel domain,Autotransporter beta-domain),Escherichia_coli_UPEC_ST131_v0.1_5_5104002-5133359.24(Serine protease sat autotransporter precursor,Immunoglobulin A1 protease),Escherichia_coli_UPEC_ST131_v0.1_5_5104002-5133359.26(Serine protease sat autotransporter precursor,Immunoglobulin A1 protease) Cluster160 1 0 4 2 0 0 0 ROD_49831(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1742(Protein of unknown function (DUF3296)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4140(Protein of unknown function (DUF3296)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4877(Protein of unknown function (DUF3296)),Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.30(Protein of unknown function (DUF3296)) b0277(CP4-6 prophage; conserved protein),b2626(CP4-57 prophage; predicted protein) Cluster161 2 0 3 1 0 1 0 ROD_33351(putative conjugative transfer system protein TraC (fragment)),ROD_49661(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1709(Toxin YeeV,Protein of unknown function (DUF1219)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4863(Toxin YeeV,Protein of unknown function (DUF1219)),Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.15(Toxin YeeV,Protein of unknown function (DUF1219)) b2005(CP4-44 prophage; toxin of the YeeV-YeeU toxin-antitoxin system) t4286(hypothetical protein) Cluster162 0 0 7 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1149(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3777(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.418(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4489(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4529(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4652(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4762(hypothetical protein) Cluster163 2 1 1 1 0 1 1 ROD_27221(conserved hypothetical protein),ROD_42311(conserved hypothetical protein) ENC_47550(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.97(Uncharacterized protein conserved in bacteria,Putative glycosyl hydrolase of unknown function (DUF1680)) pseudob4649(unknown) t3840(conserved hypothetical protein) SL1344_3644(conserved hypothetical protein) Cluster164 1 1 2 1 0 1 1 ROD_45981(putative sialic acid transporter) ENC_34670(putative sialic acid transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.475(Sialic acid permease,putative sialic acid transporter,Arabinose efflux permease,MFS transporter, sialate:H+ symporter (SHS) family,Major Facilitator Superfamily),Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.40(Sialic acid permease,putative sialic acid transporter,Arabinose efflux permease,MFS transporter, sialate:H+ symporter (SHS) family,Major Facilitator Superfamily) b3224(sialic acid transporter) t3255(putative sialic acid transporter) SL1344_3310(putative sialic acid transporter) Cluster165 1 1 1 2 0 1 1 ROD_35021(putative fimbrial subunit) ENC_32840(P pilus assembly protein, pilin FimA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.652(Fimbria A protein precursor,putative fimbrial protein,P pilus assembly protein, pilin FimA,Fimbrial protein) b0719(predicted fimbrial-like adhesin protein),b3043(predicted fimbrial-like adhesin protein) t2940(probable fimbrial protein) SL1344_3008(probable fimbrial protein) Cluster166 1 1 1 1 0 1 2 pseudoROD_20071(flagellin) ENC_28560(Flagellin and related hook-associated proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1900(Flagellin,flagellin,Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis,flagellar hook-associated protein 3,Bacterial flagellin N-terminal helical region) b1923(flagellar filament structural protein (flagellin)) t0918(flagellin) SL1344_1888(flagellin),SL1344_2756(flagellin) Cluster167 1 2 1 1 0 1 1 ROD_19241(flagellar biosynthesis protein FlhA) ENC_06150(flagellar biosynthesis protein FlhA),ENC_28800(flagellar biosynthesis protein FlhA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2003(Flagellar biosynthesis protein flhA,flagellar biosynthesis protein FlhA,Type III secretory pathway, component EscV,flagellar biosynthesis protein FlhA,FHIPEP family) b1879(predicted flagellar export pore protein) t0964(flagellar biosynthesis protein FlhA) SL1344_1848(flagellar biosynthesis protein FlhA) Cluster168 1 2 1 1 0 1 1 ROD_19411(chemotaxis protein CheA) ENC_05980(Chemotaxis protein histidine kinase and related kinases),ENC_28280(Chemotaxis protein histidine kinase and related kinases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1993(Chemotaxis protein CheA,chemotaxis protein CheA,Signal transduction histidine kinase regulating C4-dicarboxylate transport system,CheW-like domain) b1888(fused chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY: sensory histidine kinase/signal sensing protein) t0956(chemotaxis protein CheA) SL1344_1856(chemotaxis protein CheA) Cluster169 2 1 1 1 0 1 1 ROD_01271(2-keto-3-deoxygluconate permease),ROD_34801(2-keto-3-deoxygluconate permease) ENC_05440(2-keto-3-deoxygluconate permease (TC 2.A.10.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4592(2-keto-3-deoxygluconate permease,2-keto-3-deoxygluconate permease,2-keto-3-deoxygluconate transporter,2-keto-3-deoxygluconate permease) b3909(2-keto-3-deoxy-D-gluconate transporter) t0166(2-keto-3-deoxygluconate permease) SL1344_0162(2-keto-3-deoxygluconate permease) Cluster170 1 2 1 1 0 2 0 ROD_20611(conserved hypothetical protein) ENC_02870(Predicted transcriptional regulator),ENC_43950(Predicted transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1353(Predicted transcriptional regulator,Prophage CP4-57 regulatory protein (AlpA)) b2624(CP4-57 prophage; DNA-binding transcriptional activator) t2651(hypothetical protein),t4525(phage DNA binding protein) Cluster171 1 1 1 2 0 1 1 ROD_37231(putative lipoprotein) ENC_02700(Protein of unknown function (DUF2886).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4460(Group 4 capsule protein B homolog,Protein of unknown function (DUF2886)) b0986(predicted outer membrane lipoprotein),b4027(predicted lipoprotein) t4129(putative lipoprotein) SL1344_4159(putative lipoprotein) Cluster172 1 0 3 0 1 1 1 pseudoROD_48921(conserved hypothetical protein (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2517(Methyltransferase domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3445(Methyltransferase domain),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.18(Methyltransferase domain) BN373_p00431(conserved hypothetical protein) t1541(conserved hypothetical protein) SL1344_1568(possible methyltransferase) Cluster173 1 1 1 1 1 1 1 ROD_37461(bifunctional purine biosynthesis protein [includes phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase]) ENC_01200(IMP cyclohydrolase /phosphoribosylaminoimidazolecarboxamide formyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4490(Bifunctional purine biosynthesis protein PurH,bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase,Folate-dependent phosphoribosylglycinamide formyltransferase PurN,phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase,AICARFT/IMPCHase bienzyme) b4006(fused IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamide formyltransferase) BN373_50031(phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase) t3455(phosphoribosylaminoimidazolecarboxamide formyltransferase) SL1344_4115(phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase (bifunctional enzyme)) Cluster174 1 1 1 1 1 1 1 ROD_37471(phosphoribosylglycineamide synthetase) ENC_01210(phosphoribosylamine--glycine ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4491(Phosphoribosylamine--glycine ligase,phosphoribosylamine--glycine ligase,Phosphoribosylamine-glycine ligase,phosphoribosylamine--glycine ligase,Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain) b4005(phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase) BN373_50021(phosphoribosylamine--glycine ligase) t3456(phosphoribosylglycineamide synthetase) SL1344_4114(phosphoribosylglycineamide synthetase) Cluster175 1 1 1 1 1 1 1 ROD_37521(DNA-binding protein HU-alpha) ENC_01230(bacterial nucleoid protein HU alpha subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4496(NS2,transcriptional regulator HU subunit alpha,integration host factor, beta subunit,Bacterial DNA-binding protein) b4000(HU, DNA-binding transcriptional regulator, alpha subunit) BN373_49971(DNA-binding protein HU, alpha subunit) t3461(histone like DNA-binding protein HU-alpha) SL1344_4109(histone like DNA-binding protein HU-alpha (NS2) (HU-2)) Cluster176 1 1 1 1 1 1 1 ROD_37531(conserved hypothetical protein) ENC_01240(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4497(hypothetical protein,Protein of unknown function (DUF416)) b3999(conserved protein) BN373_49961(conserved hypothetical protein) t3462(conserved hypothetical protein) SL1344_4108(conserved hypothetical protein) Cluster177 1 1 1 1 1 1 1 ROD_37541(endonuclease V) ENC_01250(Endonuclease V) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4498(Endonuclease V,endonuclease V,Endonuclease V) b3998(endonuclease V) BN373_49951(endonuclease V) t3463(putative endonuclease) SL1344_4107(putative endonuclease) Cluster178 1 1 1 1 1 1 1 ROD_37551(uroporphyrinogen decarboxylase) ENC_01260(uroporphyrinogen decarboxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4499(Uroporphyrinogen decarboxylase,uroporphyrinogen decarboxylase,Uroporphyrinogen-III decarboxylase,uroporphyrinogen decarboxylase,Uroporphyrinogen decarboxylase (URO-D)) b3997(uroporphyrinogen decarboxylase) BN373_49941(uroporphyrinogen decarboxylase) t3464(uroporphyrinogen decarboxylase) SL1344_4106(uroporphyrinogen decarboxylase) Cluster179 1 1 1 1 1 1 1 ROD_37561(NADH pyrophosphatase) ENC_01270(NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4500(NADH pyrophosphatase,NADH pyrophosphatase,NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding,nucleoside triphosphatase YtkD,NUDIX domain) b3996(NADH pyrophosphatase) BN373_49931(NADH pyrophosphatase) t3465(conserved hypothetical protein) SL1344_4105(conserved hypothetical protein) Cluster180 1 1 1 1 1 1 1 ROD_37571(regulator of sigma D) ENC_01280(Regulator of sigma D) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4501(Regulator of sigma D,anti-RNA polymerase sigma 70 factor,Regulator of sigma D,Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ) b3995(stationary phase protein, binds sigma 70 RNA polymerase subunit) BN373_49921(regulator of sigma D) t3466(putative regulatory protein) SL1344_4104(putative regulatory protein) Cluster181 1 1 1 1 1 1 1 ROD_37581(thiamine biosynthesis protein) ENC_01290(hydroxymethylpyrimidine synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4503(Phosphomethylpyrimidine synthase,thiamine biosynthesis protein ThiC,Thiamine monophosphate synthase,thiamine biosynthesis protein ThiC,ThiC family) b3994(thiamin (pyrimidine moiety) biosynthesis protein) BN373_49911(thiamine biosynthesis protein ThiC) t3467(thiamine biosynthesis protein) SL1344_4103(thiamine biosynthesis protein) Cluster182 1 1 1 1 1 1 1 ROD_37591(thiamine-phosphate pyrophosphorylase) ENC_01300(thiamine-phosphate diphosphorylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4504(Thiamine-phosphate synthase,thiamine-phosphate pyrophosphorylase,Thiamine monophosphate synthase,thiamine-phosphate pyrophosphorylase,Thiamine monophosphate synthase/TENI) b3993(thiamin phosphate synthase (thiamin phosphate pyrophosphorylase)) BN373_49901(thiamine-phosphate pyrophosphorylase) t3468(thiamine-phosphate pyrophosphorylase) SL1344_4102(thiamine-phosphate pyrophosphorylase) Cluster183 1 1 1 1 1 1 1 ROD_37601(adenylyltransferase) ENC_01310([sulfur carrier protein ThiS] adenylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4505(Sulfur carrier protein ThiS adenylyltransferase,molybdopterin biosynthesis protein MoeB,thiazole biosynthesis adenylyltransferase ThiF,ThiF family) b3992(adenylyltransferase, modifies ThiS C-terminus) BN373_49891(thiazole biosynthesis adenylyltransferase ThiF) t3469(thiamine biosynthesis protein) SL1344_4101(thiamine biosynthesis protein) Cluster184 1 1 1 1 1 1 1 ROD_37611(thiamine biosynthesis protein) ENC_01320(sulfur carrier protein ThiS) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4506(Thiamine biosynthesis protein ThiS,sulfur carrier protein ThiS,thiamine biosynthesis protein ThiS,ThiS family) b4407(immediate sulfur donor in thiazole formation) BN373_49881(thiamine biosynthesis protein ThiS) t3470(thiamine biosynthesis protein) SL1344_4100(thiamine biosynthesis protein) Cluster185 1 1 1 1 1 1 1 ROD_37621(thiazole biosynthesis protein) ENC_01330(thiazole-phosphate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4507(Thiazole synthase,thiazole synthase,Thiamine monophosphate synthase,putative enoyl-[acyl-carrier-protein] reductase II,Thiazole biosynthesis protein ThiG) b3991(thiamin biosynthesis ThiGH complex subunit) BN373_49871(thiazole biosynthesis protein ThiG) t3471(thiamine biosynthesis protein) SL1344_4099(thiamine biosynthesis protein) Cluster186 1 1 1 1 1 1 1 ROD_37631(thiamine biosynthesis protein) ENC_01340(tyrosine lyase ThiH) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4508(2-iminoacetate synthase,thiamine biosynthesis protein ThiH,Thiamine monophosphate synthase,thiazole biosynthesis protein ThiH,Biotin and Thiamin Synthesis associated domain) b3990(tyrosine lyase, involved in thiamin-thiazole moiety synthesis) BN373_49861(thiazole biosynthesis protein ThiH) t3472(thiamine biosynthesis protein) SL1344_4098(thiamine biosynthesis protein) Cluster187 1 1 1 1 1 1 1 ROD_37651(DNA-directed RNA polymerase, beta-subunit) ENC_01390(DNA-directed RNA polymerase subunit beta) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4510(DNA-directed RNA polymerase subunit beta,DNA-directed RNA polymerase subunit beta,DNA-directed RNA polymerase, beta subunit,RNA polymerase Rpb2, domain 6) b3987(RNA polymerase, beta subunit) BN373_49801(DNA-directed RNA polymerase, beta subunit) t3474(DNA-directed RNA polymerase, beta-subunit) SL1344_4092(DNA-directed RNA polymerase, beta-subunit) Cluster188 1 1 1 1 1 1 1 ROD_37661(50S ribosomal subunit protein L7/L12) ENC_01400(LSU ribosomal protein L12P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4512(L8,50S ribosomal protein L7/L12,ribosomal protein L7/L12,Ribosomal protein L7/L12 C-terminal domain) b3986(50S ribosomal subunit protein L7/L12) BN373_49791(ribosomal protein L7/L12) t3475(50S ribosomal subunit protein L7/L12) SL1344_4091(50S ribosomal subunit protein L7/L12) Cluster189 1 1 1 1 1 1 1 ROD_37671(50S ribosomal subunit protein L10) ENC_01410(LSU ribosomal protein L10P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4513(50S ribosomal protein L8,50S ribosomal protein L10,Ribosomal protein L10,Ribosomal protein L10) b3985(50S ribosomal subunit protein L10) BN373_49781(ribosomal protein L10) t3476(50S ribosomal subunit protein L10) SL1344_4090(50S ribosomal subunit protein L10) Cluster190 1 1 1 1 1 1 1 ROD_37681(50S ribosomal subunit protein L1) ENC_01420(LSU ribosomal protein L1P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4514(50S ribosomal protein L1,50S ribosomal protein L1,ribosomal protein L1,Ribosomal protein L1p/L10e family) b3984(50S ribosomal subunit protein L1) BN373_49771(ribosomal protein L1) t3477(50S ribosomal subunit protein L1) SL1344_4089(50S ribosomal subunit protein L1) Cluster191 1 1 1 1 1 1 1 ROD_37691(50S ribosomal subunit protein L11) ENC_01430(LSU ribosomal protein L11P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4515(50S ribosomal protein L11,50S ribosomal protein L11,ribosomal protein L11,Ribosomal protein L11, N-terminal domain) b3983(50S ribosomal subunit protein L11) BN373_49761(ribosomal protein L11) t3478(50S ribosomal subunit protein L11) SL1344_4088(50S ribosomal subunit protein L11) Cluster192 1 1 1 1 1 1 1 ROD_37701(transcription antitermination protein) ENC_01440(transcription antitermination protein nusG) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4516(Transcription antitermination protein nusG,transcription antitermination protein NusG,transcription termination/antitermination factor NusG,Transcription termination factor nusG) b3982(transcription termination factor) BN373_49751(transcription termination/antitermination factor NusG) t3479(transcription antitermination protein) SL1344_4087(transcription antitermination protein) Cluster193 1 1 1 1 1 1 1 ROD_37711(preprotein translocase SecE subunit) ENC_01450(protein translocase subunit secE/sec61 gamma) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4517(Preprotein translocase subunit SecE,preprotein translocase subunit SecE,preprotein translocase, SecE subunit,SecE/Sec61-gamma subunits of protein translocation complex) b3981(preprotein translocase membrane subunit) BN373_49741(preprotein translocase subunit secE) t3480(preprotein translocase SecE subunit) SL1344_4086(preprotein translocase SecE subunit) Cluster194 1 1 1 1 1 1 1 ROD_37751(pantothenate kinase) ENC_01470(pantothenate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4523(Pantothenate kinase,pantothenate kinase,pantothenate kinase,Phosphoribulokinase / Uridine kinase family) b3974(pantothenate kinase) BN373_49721(pantothenate kinase) t3487(pantothenate kinase) SL1344_4083(pantothenate kinase) Cluster195 1 1 1 1 1 1 1 ROD_37771(UDP-N-acetylenolpyruvoylglucosamine reductase) ENC_27380(UDP-N-acetylmuramate dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4525(UDP-N-acetylenolpyruvoylglucosamine reductase,UDP-N-acetylenolpyruvoylglucosamine reductase,UDP-N-acetylmuramate dehydrogenase,UDP-N-acetylenolpyruvoylglucosamine reductase,UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain) b3972(UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding) BN373_49701(UDP-N-acetylenolpyruvoylglucosamine reductase) t3489(UDP-N-acetylenolpyruvoylglucosamine reductase) SL1344_4081(UDP-N-acetylenolpyruvoylglucosamine reductase) Cluster196 1 1 1 1 1 1 1 ROD_39061(trk system potassium uptake protein) ENC_47240(potassium uptake protein, TrkH family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4654(Trk system potassium uptake protein trkG,potassium transporter,potassium uptake protein, TrkH family,Cation transport protein) b3849(potassium transporter) BN373_49681(Trk system potassium uptake protein TrkH) t3312(trk system potassium uptake protein) SL1344_3939(trk system potassium uptake protein) Cluster197 1 1 1 1 1 1 1 ROD_39071(conserved hypothetical protein) ENC_47250(conserved hypothetical protein TIGR00257) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4655(IMPACT family member yigZ,hypothetical protein,uncharacterized protein, YigZ family,Uncharacterized protein family UPF0029) b3848(conserved protein, UPF0029 family) BN373_49671(conserved hypothetical protein TIGR00257) t3313(conserved hypothetical protein) SL1344_3938(conserved hypothetical protein) Cluster198 1 1 1 1 1 1 1 ROD_39081(Xaa-Pro dipeptidase) ENC_47260(Xaa-Pro dipeptidase . Metallo peptidase. MEROPS family M24B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4656(Xaa-Pro dipeptidase,proline dipeptidase,Xaa-Pro aminopeptidase,Metallopeptidase family M24) b3847(proline dipeptidase) BN373_49661(Xaa-Pro dipeptidase) t3314(proline dipeptidase) SL1344_3937(proline dipeptidase) Cluster199 1 1 1 1 1 1 1 ROD_39091(fatty oxidation complex subunit alpha [includes: enoyl-CoA hydratase; delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase; 3 hydroxybutyryl-CoA epimerase]) ENC_47270(short chain enoyl-CoA hydratase /3-hydroxyacyl-CoA dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4657(Fatty acid oxidation complex subunit alpha,multifunctional fatty acid oxidation complex subunit alpha,Predicted nucleic-acid-binding protein containing a Zn-ribbon,fatty oxidation complex, alpha subunit FadB,3-hydroxyacyl-CoA dehydrogenase, NAD binding domain) b3846(fused 3-hydroxybutyryl-CoA epimerase/delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase/enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase) BN373_49651(fatty oxidation complex, alpha subunit FadB) t3315(large (alpha) subunit of the fatty acid-oxidizing multienzyme complex) SL1344_3936(large (alpha) subunit of the fatty acid-oxidizing multienzyme complex) Cluster200 1 1 1 1 1 1 1 ROD_39101(3-ketoacyl-CoA thiolase (fatty oxidation complex beta subunit)) ENC_47280(3-ketoacyl-CoA thiolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4658(3-ketoacyl-CoA thiolase,3-ketoacyl-CoA thiolase,Uncharacterized protein, possibly involved in aromatic compounds catabolism,acetyl-CoA C-acyltransferase FadA,Thiolase, N-terminal domain) b3845(3-ketoacyl-CoA thiolase (thiolase I)) BN373_49641(acetyl-CoA C-acyltransferase FadA) t3316(small (beta) subunit of the fatty acid-oxidizing multienzyme complex) SL1344_3935(small (beta) subunit of the fatty acid-oxidizing multienzyme complex) Cluster201 1 1 1 1 1 1 1 ROD_39121(NAD(P)H-flavin reductase) ENC_01690(2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4659(NAD(P)H-flavin reductase,FMN reductase,NADH:ubiquinone oxidoreductase, Na(+)-translocating, F subunit,Oxidoreductase NAD-binding domain) b3844(NAD(P)H-flavin reductase) BN373_49631(NAD(P)H-flavin reductase) t3318(flavin reductase) SL1344_3933(flavin reductase) Cluster202 1 1 1 1 1 1 1 ROD_39131(3-octaprenyl-4-hydroxybenzoate carboxy-lyase) ENC_01700(3-octaprenyl-4hydroxybenzoate decarboxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4660(3-octaprenyl-4-hydroxybenzoate carboxy-lyase,3-octaprenyl-4-hydroxybenzoate decarboxylase,3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases,UbiD family decarboxylase,3-octaprenyl-4-hydroxybenzoate carboxy-lyase) b3843(3-octaprenyl-4-hydroxybenzoate decarboxylase) BN373_49621(3-octaprenyl-4-hydroxybenzoate carboxy-lyase) t3319(conserved hypothetical protein) SL1344_3932(conserved hypothetical protein) Cluster203 1 1 1 1 1 1 1 ROD_39141(transcriptional activator) ENC_01710(transcriptional activator RfaH) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4661(Transcriptional activator rfaH,transcriptional activator RfaH,transcriptional activator RfaH,Transcription termination factor nusG) b3842(DNA-binding transcriptional antiterminator) BN373_49611(transcriptional activator RfaH) t3320(transcriptional activator) SL1344_3931(transcriptional activator) Cluster204 1 1 1 1 1 1 1 ROD_39151(putative deoxyribonuclease) ENC_01720(Sec-independent protein translocase TatD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4662(Deoxyribonuclease TatD,DNase TatD,Mg-dependent DNase,hydrolase, TatD family,TatD related DNase) b4483(quality control of Tat-exported FeS proteins; Mg-dependent cytoplasmic DNase) BN373_49601(deoxyribonuclease TatD) t3321(putative deoxyribonuclease) SL1344_3930(putative deoxyribonuclease) Cluster205 1 1 1 1 1 1 1 ROD_39161(Sec-independent protein translocase protein) ENC_01730(Sec-independent protein translocase TatC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4663(Sec-independent protein translocase protein TatC,twin-arginine protein translocation system subunit TatC,twin arginine-targeting protein translocase TatC,Sec-independent protein translocase protein (TatC)) b3839(TatABCE protein translocation system subunit) BN373_49591(twin arginine-targeting protein translocase TatC) t3322(sec-independent protein translocase protein) SL1344_3929(sec-independent protein translocase protein) Cluster206 1 1 1 1 1 1 1 ROD_39181(Sec-independent protein translocase protein) ENC_01750(twin arginine-targeting protein translocase, TatA/E family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4665(Sec-independent protein translocase protein TatA,twin arginine translocase protein A,twin arginine-targeting protein translocase, TatA/E family,mttA/Hcf106 family) b3836(TatABCE protein translocation system subunit) BN373_49571(Sec-independent protein translocase protein TatA) t3324(sec-independent protein translocase protein) SL1344_3927(sec-independent protein translocase protein) Cluster207 1 1 1 1 1 1 1 ROD_39191(probable ubiquinone biosynthesis protein) ENC_01760(2-octaprenylphenol hydroxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4666(Probable ubiquinone biosynthesis protein UbiB,putative ubiquinone biosynthesis protein UbiB,2-polyprenylphenol 6-hydroxylase,ABC1 family) b3835(2-octaprenylphenol hydroxylase) BN373_49561(2-polyprenylphenol 6-hydroxylase) t3325(ubiquinone biosynthesis protein) SL1344_3926(ubiquinone biosynthesis protein) Cluster208 1 1 1 1 1 1 1 ROD_39211(ubiquinone/menaquinone biosynthesis methyltransferase) ENC_01780(ubiquinone/menaquinone biosynthesis methyltransferases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4668(Ubiquinone/menaquinone biosynthesis methyltransferase ubiE,ubiquinone/menaquinone biosynthesis methyltransferase,Predicted methyltransferase,ubiquinone/menaquinone biosynthesis methyltransferase,ubiE/COQ5 methyltransferase family) b3833(bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase/ S-adenosylmethionine:2-DMK methyltransferase) BN373_49541(ubiquinone/menaquinone biosynthesis methyltransferase UbiE) t3327(ubiquinone/menaquinone biosynthesis methyltransferase UbiE) SL1344_3924(ubiquinone/menaquinone biosynthesis methyltransferase UbiE) Cluster209 1 1 1 1 1 1 1 ROD_39231(uridine phosphorylase) ENC_01800(uridine phosphorylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4676(Uridine phosphorylase,uridine phosphorylase,uridine phosphorylase,Phosphorylase superfamily) b3831(uridine phosphorylase) BN373_49521(uridine phosphorylase) t3329(uridine phosphorylase) SL1344_3922(uridine phosphorylase) Cluster210 1 1 1 1 1 1 1 ROD_39241(putative carboxymethylenebutenolidase) ENC_01810(Dienelactone hydrolase and related enzymes) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4677(Carboxymethylenebutenolidase,Predicted dienelactone hydrolase,Dienelactone hydrolase family) b3830(predicted hydrolase) BN373_49511(dienelactone hydrolase family protein) t3330(putative hydrolase) SL1344_3921(putative hydrolase) Cluster211 1 1 1 1 1 1 1 ROD_39251(5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase) ENC_01820(methionine synthase (B12-independent)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4691(5-methyltetrahydropteroyltriglutamate--homocystei ne methyltransferase,5-methyltetrahydropteroyltriglutamate--ho mocysteine S-methyltransferase,5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase,Cobalamin-independent synthase, Catalytic domain) b3829(5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase) BN373_49501(5-methyltetrahydropteroyltriglutamate-homocyste ine S-methyltransferase) t3332(5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase) SL1344_3919(5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase) Cluster212 1 1 1 1 1 1 1 ROD_39261(trans-activator of metE and metH (LysR-family transcriptional regulator)) ENC_01830(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4692(HTH-type transcriptional regulator gltR,DNA-binding transcriptional regulator MetR,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b3828(DNA-binding transcriptional activator, homocysteine-binding) BN373_49491(hth-type transcriptional regulator metr) t3333(trans-activator of metE and metH) SL1344_3918(trans-activator of metE and metH) Cluster213 1 1 1 1 1 1 1 ROD_39281(haloacid dehalogenase-like hydrolase) ENC_01850(HAD-superfamily hydrolase, subfamily IIB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4694(HMP-PP phosphatase,putative hydrolase,Predicted hydrolase (HAD superfamily),Cof-like hydrolase,haloacid dehalogenase-like hydrolase) b3826(predicted hydrolase) BN373_49471(hydrolase, Cof family) t3335(conserved hypothetical protein) SL1344_3916(conserved hypothetical protein) Cluster214 1 1 1 1 1 1 1 ROD_39291(lysophospholipase L2) ENC_01860(Lysophospholipase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4695(Phospholipase ytpA,lysophospholipase L2,Esterase/lipase,alpha/beta hydrolase fold) b3825(lysophospholipase L2) BN373_49461(lysophospholipase L2) t3336(lysophospholipase L2) SL1344_3915(lysophospholipase L2) Cluster215 1 1 1 1 1 1 1 ROD_39301(homoserine/homoserine lactone efflux protein) ENC_01870(The Resistance to Homoserine/Threonine (RhtB) Family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4696(Homoserine/homoserine lactone efflux protein,homoserine/homoserine lactone efflux protein,homoserine/Threonine efflux protein,LysE type translocator) b3824(homoserine, homoserine lactone and S-methyl-methionine efflux pump) BN373_49451(homoserine/homoserine lactone efflux protein) t3337(homoserine/homoserine lactone efflux protein) SL1344_3914(homoserine/homoserine lactone efflux protein) Cluster216 1 1 1 1 1 1 1 ROD_39311(threonine efflux protein) ENC_01880(The Resistance to Homoserine/Threonine (RhtB) Family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4698(Threonine efflux protein,threonine efflux system,homoserine/Threonine efflux protein,LysE type translocator) b3823(threonine efflux pump) BN373_49431(threonine efflux protein) t3338(threonine efflux protein) SL1344_3913(threonine efflux protein) Cluster217 1 1 1 1 1 1 1 ROD_39331(phospholipase A1 (detergent resistant phospholipase A)) ENC_01900(Outer membrane phospholipase A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4700(Phospholipase A1 precursor,phospholipase A,Phospholipase A1) b3821(outer membrane phospholipase A) BN373_49411(phospholipase A1) t3340(detergent-resistant phospholipase A) SL1344_3911(detergent-resistant phospholipase A) Cluster218 1 1 1 1 1 1 1 ROD_39341(conserved hypothetical protein) ENC_01910(uncharacterized domain 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4701(hypothetical protein,Uncharacterized protein, possibly involved in aromatic compounds catabolism,uncharacterized domain 1,Thioesterase superfamily) b3820(conserved protein, 4HBT family of thioesterases) BN373_49401(thioesterase family protein) t3341(conserved hypothetical protein) SL1344_3910(conserved hypothetical protein) Cluster219 1 1 1 1 1 1 1 ROD_39371(magnesium transport protein) ENC_01930(magnesium Mg(2+) and cobalt Co(2+) transport protein (corA)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4705(Magnesium transport protein CorA,magnesium/nickel/cobalt transporter CorA,magnesium and cobalt transport protein CorA,CorA-like Mg2+ transporter protein) b3816(magnesium/nickel/cobalt transporter) BN373_49381(magnesium and cobalt transport protein CorA) t3345(magnesium and cobalt transport protein) SL1344_3906(magnesium and cobalt transport protein) Cluster220 1 1 1 1 1 1 1 ROD_39381(DNA helicase II) ENC_01940(ATP-dependent DNA helicase UvrD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4708(DNA helicase II,DNA-dependent helicase II,Superfamily I DNA and RNA helicases,DNA helicase II,UvrD/REP helicase) b3813(DNA-dependent ATPase I and helicase II) BN373_49371(DNA helicase II) t3346(DNA helicase II) SL1344_3905(DNA helicase II) Cluster221 1 1 1 1 1 1 1 ROD_39391(haloacid dehalogenase-like hydrolase) ENC_01950(haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4709(Putative HAD-hydrolase yfnB,flavin mononucleotide phosphatase,HAD hydrolase,haloacid dehalogenase-like hydrolase) b3812(FMN phosphatase) BN373_49361(HAD family hydrolase, family IA) t3347(conserved hypothetical protein) SL1344_3904(conserved hypothetical protein) Cluster222 1 1 1 1 1 1 1 ROD_39401(tyrosine recombinase) ENC_01960(tyrosine recombinase XerC subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4710(Tyrosine recombinase XerC,site-specific tyrosine recombinase XerC,Site-specific recombinase XerC,tyrosine recombinase XerC,Phage integrase family) b3811(site-specific tyrosine recombinase) BN373_49351(tyrosine recombinase XerC) t3348(integrase/recombinase) SL1344_3903(integrase/recombinase) Cluster223 1 1 1 1 1 1 1 ROD_39411(conserved hypothetical protein) ENC_01970(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4711(hypothetical protein,Uncharacterized protein conserved in bacteria,Protein of unknown function, DUF484) b3810(conserved protein, DUF484 family) BN373_49341(conserved hypothetical protein) t3349(conserved hypothetical protein) SL1344_3902(conserved hypothetical protein) Cluster224 1 1 1 1 1 1 1 ROD_39421(diaminopimelate epimerase) ENC_01980(diaminopimelate epimerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4712(Diaminopimelate epimerase,diaminopimelate epimerase,Diaminopimelate epimerase,diaminopimelate epimerase,Diaminopimelate epimerase) b3809(diaminopimelate epimerase) BN373_49331(diaminopimelate epimerase) t3350(diaminopimelate epimerase) SL1344_3901(diaminopimelate epimerase) Cluster225 1 1 1 1 1 1 1 ROD_39441(putative iron-interacting protein) ENC_01990(iron donor protein CyaY) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4715(hypothetical protein,frataxin-like protein,iron donor protein CyaY,Frataxin-like domain) b3807(iron-dependent inhibitor of iron-sulfur cluster formation; frataxin; iron-binding and oxidizing protein) BN373_49311(iron donor protein CyaY) t3354(CyaY protein) SL1344_3898(CyaY protein) Cluster226 1 1 1 1 1 1 1 ROD_39461(porphobilinogen deaminase) ENC_02030(hydroxymethylbilane synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4717(Porphobilinogen deaminase,porphobilinogen deaminase,Uroporphyrinogen-III synthase,porphobilinogen deaminase,Porphobilinogen deaminase, dipyromethane cofactor binding domain) b3805(hydroxymethylbilane synthase) BN373_49291(porphobilinogen deaminase) t3359(porphobilinogen deaminase) SL1344_3893(porphobilinogen deaminase) Cluster227 1 1 1 1 1 1 1 ROD_39481(putative uroporphyrinogen-III C-methyltransferase) ENC_02050(Uncharacterized enzyme of heme biosynthesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4719(Putative uroporphyrinogen-III C-methyltransferase,putative uroporphyrinogen III C-methyltransferase,Uroporphyrinogen-III synthase,HemX) b3803(predicted uroporphyrinogen III methyltransferase) BN373_49271(putative uroporphyrin-III C-methyltransferase) t3361(uroporphyrinogen III methylase) SL1344_3891(uroporphyrinogen III methylase) Cluster228 1 1 1 1 1 1 1 ROD_39491(Porphyrin biosynthetic protein) ENC_02060(hemY protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4720(hypothetical protein,putative protoheme IX biogenesis protein,Uncharacterized enzyme of heme biosynthesis,heme biosynthesis-associated TPR protein,HemY protein N-terminus) b3802(predicted protoheme IX synthesis protein) BN373_49261(HemY protein) t3362(porphyrin biosynthetic protein) SL1344_3890(Porphyrin biosynthetic protein) Cluster229 1 1 1 1 1 1 1 ROD_39511(probable amino acid permease) ENC_02080(Gamma-aminobutyrate permease and related permeases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4729(Probable transport protein YifK,putative transport protein YifK,Amino acid transporters,GABA permease,Amino acid permease) b3795(predicted transporter) BN373_49241(amino acid permease family protein) t3367(probable amino acid permease) SL1344_3889(probable amino acid permease) Cluster230 1 1 1 1 1 1 1 ROD_39521(UDP-N-acetyl-D-mannosaminuronic acid transferase) ENC_02090(bacterial polymer biosynthesis proteins, WecB/TagA/CpsF family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4730(Putative N-acetylmannosaminyltransferase,putative UDP-N-acetyl-D-mannosaminuronic acid transferase,glycosyltransferase, WecB/TagA/CpsF family,Glycosyl transferase WecB/TagA/CpsF family) b3794(UDP-N-acetyl-D-mannosaminuronic acid transferase) BN373_49231(glycosyl transferase, WecB/TagA/CpsF family) t3368(probable UDP-N-acetyl-D-mannosaminuronic acid transferase) SL1344_3888(probable UDP-N-acetyl-D-mannosaminuronic acid transferase) Cluster231 1 1 1 1 1 1 1 ROD_39531(putative ECA polymerase) ENC_02100(WzyE protein.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4731(putative common antigen polymerase,WzyE protein) b3793(predicted Wzy protein involved in ECA polysaccharide chain elongation) BN373_49221(ECA biosynthesis protein WzyE) t3369(probable 4-alpha-l-fucosyltransferase) SL1344_3887(probable 4-alpha-l-fucosyltransferase) Cluster232 1 1 1 1 1 1 1 ROD_39541(4-alpha-L-fucosyltransferase) ENC_02110(4-alpha-L-fucosyltransferase (Fuc4NAc transferase).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4732(4-alpha-L-fucosyltransferase,4-alpha-L-fucosyltra nsferase,4-alpha-L-fucosyltransferase (Fuc4NAc transferase)) b4481(TDP-Fuc4NAc:lipidIIFuc4NAc transferase) BN373_49211(TDP-Fuc4NAc:lipid II Fuc4Nac transferase) t3370(conserved hypothetical protein) SL1344_3886(conserved hypothetical protein) Cluster233 1 1 1 1 1 1 1 ROD_39551(lipid III flippase) ENC_02120(Membrane protein involved in the export of O-antigen and teichoic acid) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4733(hypothetical protein,O-antigen translocase,Polysaccharide biosynthesis protein) b3792(O-antigen translocase) BN373_49201(polysaccharide biosynthesis protein) t3371(putative lipopolysaccharide biosynthesis protein) SL1344_3885(putative lipopolysaccharide biosynthesis protein) Cluster234 1 1 1 1 1 1 1 ROD_39561(dTDP-4-oxo-6-deoxy-D-glucose transaminase) ENC_02130(TDP-4-keto-6-deoxy-D-glucose transaminase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4734(UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase,TDP-4-oxo-6-deoxy-D-glucose transaminase,Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis,TDP-4-keto-6-deoxy-D-glucose transaminase,DegT/DnrJ/EryC1/StrS aminotransferase family) b3791(TDP-4-oxo-6-deoxy-D-glucose transaminase) BN373_49191(TDP-4-keto-6-deoxy-D-glucose transaminase) t3372(lipopolysaccharide biosynthesis protein) SL1344_3884(lipopolysaccharide biosynthesis protein) Cluster235 1 1 1 1 1 1 1 ROD_39601(UDP-N-acetyl-D-mannosamine dehydrogenase) ENC_02150(nucleotide sugar dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4738(UDP-glucose 6-dehydrogenase ywqF,UDP-N-acetyl-D-mannosamine dehydrogenase,nucleotide sugar dehydrogenase,UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain) b3787(UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase) BN373_49151(UDP-N-acetyl-D-mannosamine dehydrogenase) t3376(UDP-ManNAc dehydrogenase) SL1344_3880(UDP-ManNAc dehydrogenase) Cluster236 1 1 1 1 1 1 1 ROD_39611(UDP-N-acetyl-D-glucosamine 2-epimerase) ENC_02160(UDP-N-Acetylglucosamine 2-epimerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4739(UDP-N-acetylglucosamine 2-epimerase,UDP-N-acetylglucosamine 2-epimerase,UDP-N-acetylglucosamine 2-epimerase,UDP-N-acetylglucosamine 2-epimerase) b3786(UDP-N-acetyl glucosamine-2-epimerase) BN373_49141(UDP-N-acetylglucosamine 2-epimerase) t3377(UDP-N-acetyl-D-glucosamine 2-epimerase) SL1344_3879(UDP-N-acetyl-D-glucosamine 2-epimerase) Cluster237 1 1 1 1 1 1 1 ROD_39641(transcription termination factor) ENC_02190(transcription termination factor Rho) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4742(Transcription termination factor Rho,transcription termination factor Rho,transcription termination factor Rho,ATP synthase alpha/beta family, nucleotide-binding domain) b3783(transcription termination factor) BN373_49111(transcription termination factor Rho) t3380(transcription termination factor) SL1344_3876(transcription termination factor) Cluster238 1 1 1 1 1 1 1 ROD_39661(thioredoxin 1) ENC_02200(thioredoxin) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4743(Thioredoxin-1,thioredoxin,thioredoxin,Thioredoxin) b3781(thioredoxin 1) BN373_49101(thioredoxin) t3381(thioredoxin) SL1344_3875(thioredoxin) Cluster239 1 1 1 1 1 1 1 ROD_39671(ATP-dependent RNA helicase) ENC_02210(Superfamily II DNA and RNA helicases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4744(ATP-dependent RNA helicase rhlB,ATP-dependent RNA helicase RhlB,Predicted transporter component,ATP-dependent DNA helicase RecQ,DEAD/DEAH box helicase) b3780(ATP-dependent RNA helicase) BN373_49091(ATP-dependent RNA helicase RhlB) t3382(putative ATP-dependent RNA helicase) SL1344_3874(putative ATP-dependent RNA helicase) Cluster240 1 1 1 1 1 1 1 ROD_39681(guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase) ENC_02220(Exopolyphosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4745(Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase,guanosine pentaphosphate phosphohydrolase,exopolyphosphatase,Ppx/GppA phosphatase family) b3779(guanosine pentaphosphatase/exopolyphosphatase) BN373_49081(guanosine-5'-triphosphate,3'-diphosphate diphosphatase) t3383(guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase) SL1344_3873(guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (guanosine pentaphosphatase)) Cluster241 1 1 1 1 1 1 1 ROD_39691(ATP-dependent DNA helicase) ENC_02230(ATP-dependent DNA helicase Rep) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4746(ATP-dependent DNA helicase rep,ATP-dependent DNA helicase Rep,Superfamily I DNA and RNA helicases,ATP-dependent DNA helicase Rep,UvrD/REP helicase) b3778(DNA helicase and single-stranded DNA-dependent ATPase) BN373_49041(ATP-dependent DNA helicase Rep) t3384(ATP-dependent DNA helicase) SL1344_3872(ATP-dependent DNA helicase) Cluster242 1 1 1 1 1 1 1 ROD_39731(peptidyl-prolyl cis-trans isomerase C) ENC_02240(Parvulin-like peptidyl-prolyl isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4747(Peptidyl-prolyl cis-trans isomerase C,peptidyl-prolyl cis-trans isomerase C,nitrogen fixation protein NifM,PPIC-type PPIASE domain) b3775(peptidyl-prolyl cis-trans isomerase C (rotamase C)) BN373_49021(peptidyl-prolyl cis-trans isomerase C) t3388(peptidyl-prolyl cis-trans isomerase C) SL1344_3870(peptidyl-prolyl cis-trans isomerase C) Cluster243 1 1 1 1 1 1 1 ROD_39741(ketol-acid reductoisomerase) ENC_47770(ketol-acid reductoisomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4748(Ketol-acid reductoisomerase,ketol-acid reductoisomerase,ketol-acid reductoisomerase,Acetohydroxy acid isomeroreductase, catalytic domain) b3774(ketol-acid reductoisomerase, NAD(P)-binding) BN373_49011(ketol-acid reductoisomerase) t3389(ketol-acid reductoisomerase) SL1344_3869(ketol-acid reductoisomerase) Cluster244 1 1 1 1 1 1 1 ROD_39761(threonine dehydratase biosynthetic (threonine deaminase)) ENC_47790(L-threonine ammonia-lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4750(L-threonine dehydratase biosynthetic IlvA,threonine dehydratase,Threonine dehydratase,threonine ammonia-lyase, biosynthetic,Pyridoxal-phosphate dependent enzyme) b3772(threonine deaminase) BN373_48991(threonine ammonia-lyase, biosynthetic) t3393(threonine deaminase) SL1344_3865(threonine deaminase) Cluster245 1 1 1 1 1 1 1 ROD_39771(dihydroxy-acid dehydratase) ENC_47800(dihydroxyacid dehydratase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4751(Dihydroxy-acid dehydratase,dihydroxy-acid dehydratase,Dihydroxyacid dehydratase/phosphogluconate dehydratase,dihydroxy-acid dehydratase,Dehydratase family) b3771(dihydroxyacid dehydratase) BN373_48981(dihydroxy-acid dehydratase) t3394(dihydroxyacid dehydratase) SL1344_3864(dihydroxyacid dehydratase) Cluster246 1 1 1 1 1 1 1 ROD_39781(branched-chain amino-acid aminotransferase) ENC_47810(branched chain amino acid aminotransferase apoenzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4752(Branched-chain-amino-acid aminotransferase,branched-chain amino acid aminotransferase,Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase,branched-chain amino acid aminotransferase,Aminotransferase class IV) b3770(branched-chain amino-acid aminotransferase) BN373_48971(branched-chain-amino-acid transaminase) t3395(branched-chain amino-acid aminotransferase) SL1344_3863(branched-chain amino-acid aminotransferase) Cluster247 1 1 1 1 1 1 1 ROD_39791(acetolactate synthase isozyme II small subunit) ENC_47820(acetolactate synthase, small subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4753(Acetolactate synthase isozyme 2 small subunit,acetolactate synthase 2 regulatory subunit,Acetolactate synthase (isozyme II), small (regulatory) subunit) b3769(acetolactate synthase II, small subunit) BN373_48961(acetolactate synthase, isozyme II, small subunit) t3396(acetohydroxy acid synthase II, small subunit) SL1344_3862(acetohydroxy acid synthase II, small subunit) Cluster248 1 1 1 1 1 1 1 ROD_39821(conserved hypothetical protein) ENC_47850(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4756(hypothetical protein,hypothetical protein,Uncharacterized protein conserved in bacteria,Protein of unknown function, DUF) b3764(conserved protein, UPF0438 family) BN373_48921(conserved hypothetical protein) t3448(conserved hypothetical protein) SL1344_3859(conserved hypothetical protein) Cluster249 1 1 1 1 1 1 1 ROD_37801(tRNA (uracil-5)-methyltransferase) ENC_01160(tRNA (uracil-5-)-methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4533(tRNA (uracil(54)-C(5))-methyltransferase,tRNA (uracil-5-)-methyltransferase,Predicted O-methyltransferase,tRNA (uracil-5-)-methyltransferase,tRNA (Uracil-5-)-methyltransferase) b3965(tRNA m(5)U54 methyltransferase, SAM-dependen) BN373_48871(tRNA (uracil-5-)-methyltransferase) t3496(tRNA (uracil-5)-methyltransferase) SL1344_4078(tRNA (uracil-5)-methyltransferase) Cluster250 1 1 1 1 1 1 1 ROD_37811(putative outer membrane protein) ENC_01150(Protein of unknown function (DUF1422).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4534(Inner membrane protein yijD,hypothetical protein,Protein of unknown function (DUF1422)) b3964(inner membrane protein, DUF1422 family) BN373_48861(putative membrane protein) t3497(putative membrane protein) SL1344_4077(putative membrane protein) Cluster251 1 1 1 1 1 1 1 ROD_37821(TetR-family trancriptional regulator) ENC_01140(Bacterial regulatory proteins, tetR family.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4535(HTH-type transcriptional repressor fabR,DNA-binding transcriptional repressor FabR,Bacterial regulatory proteins, tetR family) b3963(DNA-binding transcriptional repressor) BN373_48851(fatty acid biosynthesis regulator) t3498(possible TetR-family trancriptional regulatory protein) SL1344_4076(possible TetR-family trancriptional regulatory protein) Cluster252 1 1 1 1 1 1 1 ROD_37831(soluble pyridine nucleotide transhydrogenase) ENC_01130(Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4538(Soluble pyridine nucleotide transhydrogenase,soluble pyridine nucleotide transhydrogenase,Uncharacterized conserved protein,dihydrolipoyl dehydrogenase,Pyridine nucleotide-disulphide oxidoreductase) b3962(pyridine nucleotide transhydrogenase, soluble) BN373_48841(soluble pyridine nucleotide transhydrogenase) t3499(possible pyridine nucleotide-disulphide oxidoreductase) SL1344_4075(possible pyridine nucleotide-disulphide oxidoreductase) Cluster253 1 1 1 1 1 1 1 ROD_37841(hydrogen peroxide-inducible regulon activator) ENC_01120(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4539(Morphology and auto-aggregation control protein,DNA-binding transcriptional regulator OxyR,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b3961(DNA-binding transcriptional dual regulator) BN373_48831(hydrogen peroxide-inducible genes activator) t3500(hydrogen peroxide-inducible regulon activator) SL1344_4074(hydrogen peroxide-inducible regulon activator) Cluster254 1 1 1 1 1 1 1 ROD_37851(argininosuccinate lyase) ENC_01110(argininosuccinate lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4541(Argininosuccinate lyase,argininosuccinate lyase,Argininosuccinate lyase,argininosuccinate lyase,Lyase) b3960(argininosuccinate lyase) BN373_48821(argininosuccinate lyase) t3501(argininosuccinate lyase) SL1344_4073(argininosuccinate lyase) Cluster255 1 1 1 1 1 1 1 ROD_37861(acetylglutamate kinase) ENC_01100(N-acetylglutamate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4542(Acetylglutamate kinase,acetylglutamate kinase,Acetylglutamate kinase,acetylglutamate kinase,Amino acid kinase family) b3959(acetylglutamate kinase) BN373_48811(acetylglutamate kinase) t3502(acetylglutamate kinase) SL1344_4072(acetylglutamate kinase) Cluster256 1 1 1 1 1 1 1 ROD_37871(N-acetyl-gamma-glutamyl-phosphate reductase) ENC_01090(N-acetyl-gamma-glutamyl-phosphate reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4543(N-acetyl-gamma-glutamyl-phosphate reductase,N-acetyl-gamma-glutamyl-phosphate reductase,Acetylglutamate semialdehyde dehydrogenase,N-acetyl-gamma-glutamyl-phosphate reductase,Semialdehyde dehydrogenase, NAD binding domain) b3958(N-acetyl-gamma-glutamylphosphate reductase, NAD(P)-binding) BN373_48801(N-acetyl-gamma-glutamyl-phosphate reductase) t3503(N-acetyl-gamma-glutamyl-phosphate reductase) SL1344_4071(N-acetyl-gamma-glutamyl-phosphate reductase) Cluster257 1 1 1 1 1 1 1 ROD_37881(acetylornithine deacetylase) ENC_01080(acetylornithine deacetylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4544(Acetylornithine deacetylase,acetylornithine deacetylase,acetylornithine deacetylase (ArgE),Peptidase family M20/M25/M40) b3957(acetylornithine deacetylase) BN373_48791(acetylornithine deacetylase) t3504(acetylornithine deacetylase) SL1344_4070(acetylornithine deacetylase) Cluster258 1 1 1 1 1 1 1 ROD_37891(phosphoenolpyruvate carboxylase) ENC_01070(Phosphoenolpyruvate carboxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4545(Phosphoenolpyruvate carboxylase,phosphoenolpyruvate carboxylase,Uncharacterized protein conserved in archaea,Phosphoenolpyruvate carboxylase) b3956(phosphoenolpyruvate carboxylase) BN373_48781(phosphoenolpyruvate carboxylase) t3505(phosphoenolpyruvate carboxylase) SL1344_4069(phosphoenolpyruvate carboxylase) Cluster259 1 1 1 1 1 1 1 ROD_37991(glycerol dehydrogenase) ENC_01050(glycerol 2-dehydrogenase (NAD+)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4555(Glycerol dehydrogenase,glycerol dehydrogenase,Glycerol dehydrogenase and related enzymes,lactaldehyde reductase,Iron-containing alcohol dehydrogenase) b3945(glycerol dehydrogenase, NAD) BN373_48741(glycerol dehydrogenase) t3509(glycerol dehydrogenase) SL1344_4058(glycerol dehydrogenase) Cluster260 1 1 1 1 1 1 1 ROD_38011(5,10-methylenetetrahydrofolate reductase) ENC_01030(5,10-methylenetetrahydrofolate reductase, prokaryotic form) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4559(5,10-methylenetetrahydrofolate reductase,5,10-methylenetetrahydrofolate reductase,5,10-methylenetetrahydrofolate reductase,Methylenetetrahydrofolate reductase) b3941(5,10-methylenetetrahydrofolate reductase) BN373_48721(5,10-methylenetetrahydrofolate reductase) t3511(5,10 methylenetetrahydrofolate reductase) SL1344_4055(5,10 methylenetetrahydrofolate reductase) Cluster261 1 1 1 1 1 1 1 ROD_38031(bifunctional aspartokinase/homoserine dehydrogenase II]) ENC_01020(aspartate kinase /homoserine dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4562(Aspartokinase II/homoserine dehydrogenase II,bifunctional aspartate kinase II/homoserine dehydrogenase II,Homoserine dehydrogenase,aspartate kinase,Homoserine dehydrogenase) b3940(fused aspartokinase II/homoserine dehydrogenase II) BN373_48671(aspartokinase/homoserine dehydrogenase II) t3517(aspartokinase II) SL1344_4050(bifunctional aspartokinase II/homoserine dehydrogenase IIcan I write) Cluster262 1 1 1 1 1 1 1 ROD_38041(cystathionine gamma-synthase) ENC_01010(O-succinylhomoserine (thiol)-lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4563(Cystathionine gamma-synthase,cystathionine gamma-synthase,Protoheme ferro-lyase (ferrochelatase),O-succinylhomoserine (thiol)-lyase,Cys/Met metabolism PLP-dependent enzyme) b3939(cystathionine gamma-synthase, PLP-dependent) BN373_48661(O-succinylhomoserine (thiol)-lyase) t3518(cystathionine gamma-synthase) SL1344_4049(cystathionine gamma-synthase) Cluster263 1 1 1 1 1 1 1 ROD_38061(repressor of the methionine regulon) ENC_01000(Transcriptional regulator of met regulon) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4564(Met regulon regulatory protein metJ,transcriptional repressor protein MetJ,Met Apo-repressor, MetJ) b3938(DNA-binding transcriptional repressor, S-adenosylmethionine-binding) BN373_48651(met repressor) t3519(repressor of the methionine regulon) SL1344_4048(repressor of the methionine regulon) Cluster264 1 1 1 1 1 1 1 ROD_38101(50S ribosomal subunit protein L31) ENC_00990(LSU ribosomal protein L31P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4566(50S ribosomal protein L31,50S ribosomal protein L31,Ribosomal protein L31,ribosomal protein L31,Ribosomal protein L31) b3936(50S ribosomal subunit protein L31) BN373_48641(50S ribosomal protein L31) t3522(50S ribosomal protein L31) SL1344_4045(50S ribosomal protein L31) Cluster265 1 1 1 1 1 1 1 ROD_38111(primosomal protein replication factor) ENC_00980(replication restart DNA helicase PriA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4567(Primosomal protein N',primosome assembly protein PriA,ATP-dependent protease HslVU (ClpYQ), peptidase subunit,primosomal protein N',DEAD/DEAH box helicase) b3935(Primosome factor n' (replication factor Y)) BN373_48631(primosomal protein N') t3523(primosomal protein replication factor) SL1344_4044(primosomal protein replication factor) Cluster266 1 1 1 1 1 1 1 ROD_38121(LacI-family transcriptional repressor) ENC_00970(transcriptional regulator, LacI family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4568(HTH-type transcriptional repressor CytR,DNA-binding transcriptional regulator CytR,ATP-dependent protease HslVU (ClpYQ), peptidase subunit,catabolite control protein A,Periplasmic binding proteins and sugar binding domain of LacI family) b3934(DNA-binding transcriptional dual regulator) BN373_48621(transcriptional repressor CytR) t3524(transcriptional repressor) SL1344_4043(transcriptional repressor) Cluster267 1 1 1 1 1 1 1 ROD_38131(cell division protein) ENC_00960(cell division protein FtsN) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4569(Cell division protein FtsN,essential cell division protein FtsN,Uncharacterized protein conserved in bacteria,cell division protein FtsN,Sporulation related domain) b3933(essential cell division protein) BN373_48611(cell division protein FtsN) t3525(cell division protein) SL1344_4042(cell division protein) Cluster268 1 1 1 1 1 1 1 ROD_38151(ATP-dependent Hsl protease ATP-binding subunit (heat shock protein)) ENC_00940(heat shock protein HslVU, ATPase subunit HslU) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4571(Unfoldase HslU,ATP-dependent protease ATP-binding subunit HslU,DnaK suppressor protein,ATP-dependent protease HslVU, ATPase subunit,AAA domain (Cdc48 subfamily)) b3931(molecular chaperone and ATPase component of HslUV protease) BN373_48591(heat shock protein HslVU, ATPase subunit HslU) t3527(heat shock protein) SL1344_4040(heat shock protein) Cluster269 1 1 1 1 1 1 1 ROD_38161(1,4-dihydroxy-2-naphthoate octaprenyltransferase) ENC_00930(1,4-dihydroxy-2-naphtoate prenyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4572(1,4-dihydroxy-2-naphthoate octaprenyltransferase,1,4-dihydroxy-2-naphthoate octaprenyltransferase,ATP-dependent protease HslVU (ClpYQ), peptidase subunit,1,4-dihydroxy-2-naphthoate octaprenyltransferase,UbiA prenyltransferase family) b3930(1,4-dihydroxy-2-naphthoate octaprenyltransferase) BN373_48581(1,4-dihydroxy-2-naphthoate octaprenyltransferase) t3528(menaquinone biosynthetic protein) SL1344_4039(menaquinone biosynthetic protein) Cluster270 1 1 1 1 1 1 1 ROD_38171(regulator of ribonuclease activity A) ENC_00920(regulator of ribonuclease activity A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4573(Regulator of ribonuclease activity A,ribonuclease activity regulator protein RraA,ATP-dependent protease HslVU (ClpYQ), peptidase subunit,regulator of ribonuclease activity A,Demethylmenaquinone methyltransferase) b3929(ribonuclease E (RNase E) inhibitor protein) BN373_48571(regulator of ribonuclease activity A) t3529(menaquinone biosynthesis protein) SL1344_4038(menaquinone biosynthesis protein) Cluster271 1 1 1 1 1 1 1 ROD_38341(6-phosphofructokinase isozyme 1) ENC_00770(6-phosphofructokinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4586(6-phosphofructokinase isozyme 1,6-phosphofructokinase,P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein,6-phosphofructokinase,Phosphofructokinase) b3916(6-phosphofructokinase I) BN373_48561(6-phosphofructokinase) t3557(6-phosphofructokinase) SL1344_4011(6-phosphofructokinase) Cluster272 1 1 1 1 1 1 1 ROD_38351(ferrous-iron efflux pump) ENC_00760(cation diffusion facilitator family transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4587(Ferrous-iron efflux pump FieF,ferrous iron efflux protein F,Predicted Co/Zn/Cd cation transporters,cation diffusion facilitator family transporter,Cation efflux family) b3915(ferrous iron and zinc transporter) BN373_48551(ferrous-iron efflux pump FieF) t3558(putative transmembrane efflux protein) SL1344_4010(putative transmembrane efflux protein) Cluster273 1 1 1 1 1 1 1 ROD_38372(periplasmic protein CpxP) ENC_00750(P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4588(Periplasmic protein CpxP precursor,periplasmic repressor CpxP,P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein,LTXXQ motif) b4484(inhibitor of the cpx response; periplasmic adaptor protein) BN373_48541(periplasmic protein CpxP) t3559(extracytoplasmic stress protein for protein-mediated toxicities) SL1344_4009(extracytoplasmic stress protein for protein-mediated toxicities) Cluster274 1 1 1 1 1 1 1 ROD_38381(two-component response regulator) ENC_00740(Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4589(Transcriptional regulatory protein walR,DNA-binding transcriptional regulator CpxR,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain) b3912(DNA-binding response regulator in two-component regulatory system with CpxA) BN373_48531(transcriptional regulatory protein CpxR) t3560(two-component response regulatory protein) SL1344_4008(two-component response regulatory protein) Cluster275 1 1 1 1 1 1 1 ROD_38391(two-component sensor kinase) ENC_00730(Signal transduction histidine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4590(Sensor protein CpxA,two-component sensor protein,Predicted periplasmic ligand-binding sensor domain,heavy metal sensor kinase,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b3911(sensory histidine kinase in two-component regulatory system with CpxR) BN373_48521(sensor protein CpxA) t3561(two-component sensor kinase protein) SL1344_4007(two-component sensor kinase protein) Cluster276 1 1 1 1 1 1 1 ROD_38411(conserved hypothetical protein) ENC_00710(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4591(hypothetical protein,6-N-hydroxylaminopurine resistance protein,MOSC domain) b3910(6-N-hydroxylaminopurine resistance protein) BN373_48511(MOSC domain protein) t3563(conserved hypothetical protein) SL1344_4005(conserved hypothetical protein) Cluster277 1 1 1 1 1 1 1 ROD_38431(superoxide dismutase) ENC_00700(Superoxide dismutase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4593(Superoxide dismutase [Mn],superoxide dismutase,Iron/manganese superoxide dismutases, C-terminal domain) b3908(superoxide dismutase, Mn) BN373_48501(superoxide dismutase (Mn)) t3564(manganese superoxide dismutase) SL1344_4004(manganese superoxide dismutase) Cluster278 1 1 1 1 1 1 1 ROD_38441(L rhamnose-proton symporter) ENC_00690(RhaT L-rhamnose-proton symporter family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4594(L-rhamnose-H(+) transport protein,rhamnose-proton symporter,RhaT L-rhamnose-proton symporter family protein,L-rhamnose-proton symport protein (RhaT)) b3907(L-rhamnose:proton symporter) BN373_48491(L-rhamnose-proton symporter RhaT) t3569(L rhamnose-proton symporter) SL1344_3999(L rhamnose-proton symporter) Cluster279 1 1 1 1 1 1 1 ROD_38461(L-rhamnose operon regulatory protein) ENC_00670(transcriptional regulator, AraC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4596(L-rhamnose operon regulatory protein rhaS,transcriptional activator RhaS,DNA gyrase inhibitor,YSIRK-targeted surface antigen transcriptional regulator,Helix-turn-helix domain) b3905(DNA-binding transcriptional activator for rhaBAD and rhaT, L-rhamnose-binding) BN373_48471(HTH-type transcriptional activator RhaS) t3571(L-rhamnose operon regulatory protein) SL1344_3997(L-rhamnose operon regulatory protein) Cluster280 1 1 1 1 1 1 1 ROD_38471(rhamnulokinase) ENC_00650(L-rhamnulokinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4597(Rhamnulokinase,rhamnulokinase,L-rhamnose isomerase,rhamnulokinase,FGGY family of carbohydrate kinases, N-terminal domain) b3904(rhamnulokinase) BN373_48461(rhamnulokinase) t3572(rhamnulokinase) SL1344_3996(rhamnulokinase) Cluster281 1 1 1 1 1 1 1 ROD_38481(L-rhamnose isomerase) ENC_00640(L-rhamnose isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4598(L-rhamnose isomerase,L-rhamnose isomerase,L-rhamnose isomerase,L-rhamnose isomerase,L-rhamnose isomerase (RhaA)) b3903(L-rhamnose isomerase) BN373_48451(L-rhamnose isomerase) t3573(L-rhamnose isomerase) SL1344_3995(L-rhamnose isomerase) Cluster282 1 1 1 1 1 1 1 ROD_38511(conserved hypothetical protein) ENC_00570(L-rhamnose 1-epimerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4600(L-rhamnose mutarotase,Uncharacterized conserved protein,L-rhamnose 1-epimerase,Domain of unknown function (DUF718)) b3901(L-rhamnose mutarotase) BN373_48381(L-rhamnose 1-epimerase) t3576(conserved hypothetical protein) SL1344_3992(conserved hypothetical protein) Cluster283 1 1 1 1 1 1 1 ROD_38651(formate dehydrogenase-O, iron-sulfur subunit) ENC_00420(formate dehydrogenase beta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4605(Formate dehydrogenase-O subunit beta,hydrogenase 2 protein HybA,Ferredoxin-like protein,formate dehydrogenase, beta subunit,Formate dehydrogenase N, transmembrane) b3893(formate dehydrogenase-O, Fe-S subunit) BN373_48211(formate dehydrogenase-O, iron-sulfur subunit) t3584(formate dehydrogenase-O beta subunit) SL1344_3983(formate dehydrogenase-O beta subunit) Cluster284 1 1 1 1 1 1 1 ROD_38661(formate dehydrogenase, cytochrome b556(fdo) subunit) ENC_00410(formate dehydrogenase gamma subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4606(Formate dehydrogenase-O subunit gamma,formate dehydrogenase-O subunit gamma,formate dehydrogenase, gamma subunit,Cytochrome b(N-terminal)/b6/petB) b3892(formate dehydrogenase-O, cytochrome b556 subunit) BN373_48201(formate dehydrogenase-O, gamma subunit) t3585(formate dehydrogenase-O gamma subunit) SL1344_3982(formate dehydrogenase-O gamma subunit) Cluster285 1 1 1 1 1 1 1 ROD_38671(putative formate dehydrogenase formation protein) ENC_00400(formate dehydrogenase accessory protein FdhE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4607(hypothetical protein,formate dehydrogenase accessory protein FdhE,Uncharacterized protein involved in formate dehydrogenase formation,formate dehydrogenase accessory protein FdhE,Protein involved in formate dehydrogenase formation) b3891(formate dehydrogenase formation protein) BN373_48191(formate dehydrogenase accessory protein FdhE) t3586(FdhE protein) SL1344_3981(FdhE protein) Cluster286 1 1 1 1 1 1 1 ROD_38721(putative acetyltransferase) ENC_00360(thioesterase domain, putative) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4617(N-acetylglutamate synthase,putative thioesterase domain,Putative thioesterase (yiiD_Cterm)) b3888(predicted acetyltransferase) BN373_48151(thioesterase/acetyltransferase domain protein) t3592(putative acetyltransferase) SL1344_3975(putative acetyltransferase) Cluster287 1 1 1 1 1 1 1 ROD_38731(D-tyrosyl-tRNA(Tyr) deacylase) ENC_00350(D-tyrosyl-tRNA(Tyr) deacylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4618(D-tyrosyl-tRNA(Tyr) deacylase,D-tyrosyl-tRNA(Tyr) deacylase,D-tyrosyl-tRNA(Tyr) deacylase,D-Tyr-tRNA(Tyr) deacylase) b3887(D-tyr-tRNA(Tyr) deacylase) BN373_48141(D-tyrosyl-tRNA(Tyr) deacylase) t3593(conserved hypothetical protein) SL1344_3974(conserved hypothetical protein) Cluster288 1 1 1 1 1 1 1 ROD_38741(tRNA-processing ribonuclease BN) ENC_00340(tRNA-processing RNAse BN) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4619(hypothetical protein,hypothetical protein,YihY family inner membrane protein,Ribonuclease BN-like family) b3886(predicted inner membrane protein) BN373_48131(tRNA-processing ribonuclease BN) t3594(ribonuclease BN) SL1344_3973(ribonuclease BN) Cluster289 1 1 1 1 1 1 1 ROD_38751(phosphatase) ENC_00330(haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4620(Phosphatase yihX,?-D-glucose-1-phosphatase,epoxide hydrolase N-terminal domain-like phosphatase,haloacid dehalogenase-like hydrolase) b3885(alpha-D-Glucose-1-P phosphatase, anomer-specific) BN373_48121(phosphatase YihX) t3595(putative haloacid dehalogenase-like hydrolase) SL1344_3972(putative haloacid dehalogenase-like hydrolase) Cluster290 1 1 1 1 1 1 1 ROD_38911(glutamine synthetase) ENC_00220(L-glutamine synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4630(Glutamine synthetase,glutamine synthetase,Predicted metal-dependent hydrolase of the TIM-barrel fold,glutamine synthetase, type I,Glutamine synthetase, catalytic domain) b3870(glutamine synthetase) BN373_48101(glutamine synthetase) t3614(glutamine synthetase) SL1344_3954(glutamine synthetase) Cluster291 1 1 1 1 1 1 1 ROD_38921(nitrogen regulation protein NR(II) (two-component system sensor kinase)) ENC_00210(PAS/PAC sensor signal transduction histidine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4631(Nitrogen regulation protein NR(II),nitrogen regulation protein NR(II),Signal transduction histidine kinase, nitrogen specific,phosphate regulon sensor kinase PhoR,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b3869(sensory histidine kinase in two-component regulatory system with GlnG) BN373_48091(nitrogen regulation protein NR(II)) t3615(two-component system sensory histidine kinase) SL1344_3953(Two-component system sensory histidine kinase) Cluster292 1 1 1 1 1 1 1 ROD_38941(oxygen-independent coproporphyrinogen III oxidase) ENC_00190(coproporphyrinogen III oxidase, anaerobic) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4634(Oxygen-independent coproporphyrinogen-III oxidase,coproporphyrinogen III oxidase,Putative heme iron utilization protein,oxygen-independent coproporphyrinogen III oxidase,HemN C-terminal region) b3867(coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-independent) BN373_48071(oxygen-independent coproporphyrinogen III oxidase) t3617(oxygen-independent coproporphyrinogen III oxidase) SL1344_3951(oxygen-independent coproporphyrinogen III oxidase) Cluster293 1 1 1 1 1 1 1 ROD_38951(conserved hypothetical protein) ENC_00180(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4635(Der GTPase-activating protein YihI,Der GTPase activator,Protein of unknown function, DUF414) b3866(activator of Der GTPase) BN373_48061(conserved hypothetical protein) t3618(conserved hypothetical protein) SL1344_3950(conserved hypothetical protein) Cluster294 1 1 1 1 1 1 1 ROD_38981(putative acyltransferase) ENC_00150(1-acyl-sn-glycerol-3-phosphate acyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4642(Probable acyltransferase yihG,putative acyltransferase,1-acylglycerol-3-phosphate O-acyltransferases,Acyltransferase) b3862(inner membrane protein, Predicted acyltransferas) BN373_48031(acyltransferase domain protein) t3622(putative acyltransferase) SL1344_3946(putative acyltransferase) Cluster295 1 1 1 1 1 1 1 ROD_38991(thiol:disulfide interchange protein) ENC_00140(DSBA-like thioredoxin domain.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4645(Thiol:disulfide interchange protein DsbA precursor,periplasmic protein disulfide isomerase I,Uncharacterized protein conserved in bacteria,DSBA-like thioredoxin domain) b3860(periplasmic protein disulfide isomerase I) BN373_48021(thiol:disulfide interchange protein DsbA) t3623(thiol:disulfide interchange protein) SL1344_3945(thiol:disulfide interchange protein) Cluster296 1 1 1 1 1 1 1 ROD_39001(putative regulatory protein kinase) ENC_00130(Putative homoserine kinase type II (protein kinase fold)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4646(hypothetical protein,serine/threonine protein kinase,spore coat protein, CotS family,Phosphotransferase enzyme family) b3859(Thr/Ser kinase implicated in Cpx stress response) BN373_48011(protein serine/threonine kinase RdoA) t3624(conserved hypothetical protein) SL1344_3944(conserved hypothetical protein) Cluster297 1 1 1 1 1 1 1 ROD_39011(conserved hypothetical protein) ENC_00120(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4647(hypothetical protein,Protein of unknown function (DUF1040)) b3858(DUF1040 protein YihD) BN373_48001(conserved hypothetical protein) t3625(conserved hypothetical protein) SL1344_3943(conserved hypothetical protein) Cluster298 1 1 1 1 1 1 1 ROD_39021(molybdopterin-guanine dinucleotide biosynthesis protein A) ENC_00110(molybdenum cofactor guanylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4648(hypothetical protein,molybdopterin-guanine dinucleotide biosynthesis protein MobA,Molybdopterin-guanine dinucleotide biosynthesis protein,molybdopterin-guanine dinucleotide biosynthesis protein A,MobA-like NTP transferase domain) b3857(molybdopterin-guanine dinucleotide synthase) BN373_47991(molybdopterin-guanine dinucleotide biosynthesis protein A) t3626(molybdopterin-guanine dinucleotide biosynthesis protein A) SL1344_3942(molybdopterin-guanine dinucleotide biosynthesis protein A) Cluster299 1 1 1 1 1 1 1 ROD_39031(molybdopterin-guanine dinucleotide biosynthesis protein B) ENC_00100(molybdopterin-guanine dinucleotide biosynthesis protein MobB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4649(Molybdopterin-guanine dinucleotide biosynthesis protein B,molybdopterin-guanine dinucleotide biosynthesis protein B,Molybdopterin-guanine dinucleotide biosynthesis protein,molybdopterin-guanine dinucleotide biosynthesis protein B,Molybdopterin guanine dinucleotide synthesis protein B) b3856(molybdopterin-guanine dinucleotide biosynthesis protein B) BN373_47981(molybdopterin-guanine dinucleotide biosynthesis protein B) t3627(molybdopterin-guanine dinucleotide biosynthesis protein B) SL1344_3941(molybdopterin-guanine dinucleotide biosynthesis protein B) Cluster300 1 1 1 1 1 1 1 ROD_39841(GntR-family transcriptional regulator) ENC_04410(transcriptional regulator, GntR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4763(Pyruvate dehydrogenase complex repressor,transcriptional regulator NanR,Transcriptional regulators,phosphonate utilization associated transcriptional regulator,Bacterial regulatory proteins, gntR family) b3755(predicted transcriptional regulator) BN373_47971(transcriptional regulator, GntR family) t3631(hypothetical 20.8 kDa protein in rbsr-rrsc intergenic region) SL1344_3857(hypothetical 20.8 kDa protein in rbsr-rrsc intergenic region) Cluster301 1 1 1 1 1 1 1 ROD_39861(ribose operon repressor) ENC_04390(transcriptional regulator, LacI family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4765(Ribose operon repressor,transcriptional repressor RbsR,ABC-type sugar transport system, periplasmic component,catabolite control protein A,Periplasmic binding proteins and sugar binding domain of LacI family) b3753(DNA-binding transcriptional repressor of ribose metabolism) BN373_47951(ribose operon repressor) t3633(ribose operon repressor) SL1344_3853(ribose operon repressor) Cluster302 1 1 1 1 1 1 1 ROD_39871(ribokinase) ENC_04380(ribokinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4766(Ribokinase,ribokinase,Uncharacterized protein conserved in bacteria,ribokinase,pfkB family carbohydrate kinase) b3752(ribokinase) BN373_47941(ribokinase) t3634(ribokinase) SL1344_3852(ribokinase) Cluster303 1 1 1 1 1 1 1 ROD_39881(D-ribose ABC transporter, substrate-binding protein) ENC_04370(ribose-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4767(D-ribose-binding periplasmic protein precursor,D-ribose transporter subunit RbsB,ABC-type sugar transport system, periplasmic component,D-xylose ABC transporter, D-xylose-binding protein,Periplasmic binding proteins and sugar binding domain of LacI family) b3751(D-ribose transporter subunit) BN373_47931(ribose ABC transporter, periplasmic D-ribose-binding protein) t3635(D-ribose-binding periplasmic protein) SL1344_3851(D-ribose-binding periplasmic protein) Cluster304 1 1 1 1 1 1 1 ROD_39891(ribose ABC transporter, permease protein) ENC_04360(ribose ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4768(Ribose transport system permease protein rbsC,ribose ABC transporter permease protein,Predicted ABC-type sugar transport system, permease component,urea ABC transporter, permease protein UrtB,Branched-chain amino acid transport system / permease component) b3750(D-ribose transporter subunit) BN373_47921(ribose ABC transporter, permease protein) t3636(high affinity ribose transport protein) SL1344_3850(high affinity ribose transport protein) Cluster305 1 1 1 1 1 1 1 ROD_39901(ribose ABC transporter, ATP-binding protein) ENC_04350(ribose ABC transporter ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4769(Ribose import ATP-binding protein RbsA,D-ribose transporter ATP binding protein,Predicted periplasmic lipoprotein,D-xylose ABC transporter, ATP-binding protein,ABC transporter) b3749(fused D-ribose transporter subunits of ABC superfamily: ATP-binding components) BN373_47911(ribose ABC transporter, ATP-binding protein) t3637(high affinity ribose transport protein) SL1344_3849(high affinity ribose transport protein) Cluster306 1 1 1 1 1 1 1 ROD_39911(putative ribose transport/metabolism protein) ENC_04340(ribose transport protein RbsD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4770(D-ribose pyranase,D-ribose pyranase,ABC-type ribose transport system, auxiliary component,RbsD / FucU transport protein family) b3748(predicted cytoplasmic sugar-binding protein) BN373_47901(high affinity ribose transport protein RbsD) t3638(high affinity ribose transport protein RbsD) SL1344_3848(high affinity ribose transport protein RbsD) Cluster307 1 1 1 1 1 1 1 ROD_39921(low affinity potassium transport system protein) ENC_04330(potassium uptake protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4771(potassium transport protein Kup,potassium uptake protein,K+ potassium transporter) b3747(potassium transporter) BN373_47891(potassium uptake protein) t3639(membrane transport protein) SL1344_3847(membrane transport protein) Cluster308 1 1 1 1 1 1 1 ROD_39941(regulatory ATPase variant A) ENC_04320(MoxR-like ATPases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4772(ATPase ravA,regulatory ATPase RavA,Mg-chelatase subunit ChlI,AAA domain (dynein-related subfamily)) b3746(fused predicted transcriptional regulator: sigma54 activator protein/conserved protein) BN373_47881(ATPase RavA) t3640(conserved hypothetical protein) SL1344_3846(conserved hypothetical protein) Cluster309 1 1 1 1 1 1 1 ROD_39951(protein ViaA (VWA domain protein interacting with AAA ATPase)) ENC_04310(Uncharacterized protein containing a von Willebrand factor type A (vWA) domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4773(VWA domain protein interacting with AAA ATPase,hypothetical protein,VWA domain containing CoxE-like protein) b3745(predicted von Willibrand factor containing protein) BN373_47871(ViaA family protein) t3641(conserved hypothetical protein) SL1344_3845(conserved hypothetical protein) Cluster310 1 1 1 1 1 1 1 ROD_39961(aspartate--ammonia ligase (asparagine synthetase A)) ENC_04300(aspartate-ammonia ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4774(Aspartate--ammonia ligase,asparagine synthetase AsnA,aspartate--ammonia ligase,Aspartate-ammonia ligase) b3744(asparagine synthetase A) BN373_47861(aspartate--ammonia ligase) t3642(asparagine synthetase A) SL1344_3844(asparagine synthetase A) Cluster311 1 1 1 1 1 1 1 ROD_39971(regulatory protein) ENC_04290(transcriptional regulator, AsnC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4775(Regulatory protein AsnC,DNA-binding transcriptional regulator AsnC,AsnC family) b3743(DNA-binding transcriptional dual regulator) BN373_47851(regulatory protein AsnC) t3643(regulatory protein) SL1344_3843(regulatory protein) Cluster312 1 1 1 1 1 1 1 ROD_39981(flavoprotein) ENC_04280(Flavodoxins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4776(hypothetical protein,FMN-binding protein MioC,Nitric oxide synthase, oxygenase domain,sulfite reductase [NADPH] flavoprotein, alpha-component,Flavodoxin) b3742(FMN-binding protein MioC) BN373_47841(MioC protein) t3644(MioC protein) SL1344_3842(MioC protein) Cluster313 1 1 1 1 1 1 1 ROD_39991(tRNA uridine 5-carboxymethylaminomethyl modification enzyme (glucose-inhibited division protein A)) ENC_04270(glucose-inhibited division protein A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4777(Glucose-inhibited division protein A,tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA,Proteins involved in synaptic transmission and general secretion, Sec1 family,tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA,Glucose inhibited division protein A) b3741(5-methylaminomethyl-2-thiouridine modification at tRNA U34) BN373_47831(tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA) t3645(glucose inhibited division protein) SL1344_3841(glucose inhibited division protein) Cluster314 1 1 1 1 1 1 1 ROD_40011(ATP synthase protein I) ENC_04250(F0F1-type ATP synthase, subunit I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4779(ATP synthase protein I,F0F1 ATP synthase subunit I,ATP synthase I chain) b3739(ATP synthase, membrane-bound accessory factor) BN373_47811(ATP synthase F0, I subunit) t3647(ATP synthase protein I) SL1344_3839(ATP synthase protein I) Cluster315 1 1 1 1 1 1 1 ROD_40021(ATP synthase subunit A) ENC_04240(ATP synthase F0 subcomplex A subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4780(F-ATPase subunit 6,F0F1 ATP synthase subunit A,F0F1-type ATP synthase, beta subunit,ATP synthase F0, A subunit,ATP synthase A chain) b3738(F0 sector of membrane-bound ATP synthase, subunit a) BN373_47801(ATP synthase F0, A subunit) t3648(ATP synthase A chain) SL1344_3838(ATP synthase A chain) Cluster316 1 1 1 1 1 1 1 ROD_40031(ATP synthase subunit C) ENC_04230(ATP synthase, F0 subunit c) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4781(Lipid-binding protein,F0F1 ATP synthase subunit C,F0F1-type ATP synthase, beta subunit,ATP synthase F0, C subunit,ATP synthase subunit C) b3737(F0 sector of membrane-bound ATP synthase, subunit c) BN373_47791(ATP synthase F0, C subunit) t3649(ATP synthase subunit C) SL1344_3837(ATP synthase subunit C) Cluster317 1 1 1 1 1 1 1 ROD_40041(ATP synthase subunit B) ENC_04220(ATP synthase F0 subcomplex B subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4782(F-type ATPase subunit b,F0F1 ATP synthase subunit B,F0F1-type ATP synthase, beta subunit,ATP synthase F0, B subunit,ATP synthase B/B' CF(0)) b3736(F0 sector of membrane-bound ATP synthase, subunit b) BN373_47781(ATP synthase F0, B subunit) t3650(ATP synthase subunit B) SL1344_3836(ATP synthase subunit B) Cluster318 1 1 1 1 1 1 1 ROD_40051(ATP synthase delta subunit) ENC_04210(ATP synthase, F1 delta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4783(F-type ATPase subunit delta,F0F1 ATP synthase subunit delta,F0F1-type ATP synthase, beta subunit,ATP synthase F1, delta subunit,ATP synthase delta (OSCP) subunit) b3735(F1 sector of membrane-bound ATP synthase, delta subunit) BN373_47771(ATP synthase F1, delta subunit) t3651(ATP synthase delta subunit) SL1344_3835(ATP synthase delta subunit) Cluster319 1 1 1 1 1 1 1 ROD_40061(ATP synthase alpha subunit) ENC_04200(proton translocating ATP synthase, F1 alpha subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4784(ATP synthase subunit alpha,F0F1 ATP synthase subunit alpha,F0F1-type ATP synthase, beta subunit,ATP synthase F1, alpha subunit,ATP synthase alpha/beta family, nucleotide-binding domain) b3734(F1 sector of membrane-bound ATP synthase, alpha subunit) BN373_47761(ATP synthase F1, alpha subunit) t3652(ATP synthase alpha subunit) SL1344_3834(ATP synthase alpha subunit) Cluster320 1 1 1 1 1 1 1 ROD_40071(ATP synthase gamma subunit) ENC_04190(ATP synthase F1 subcomplex gamma subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4785(F-ATPase gamma subunit,F0F1 ATP synthase subunit gamma,F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit),ATP synthase F1, gamma subunit,ATP synthase) b3733(F1 sector of membrane-bound ATP synthase, gamma subunit) BN373_47751(ATP synthase F1, gamma subunit) t3653(ATP synthase gamma subunit) SL1344_3833(ATP synthase gamma subunit) Cluster321 1 1 1 1 1 1 1 ROD_40081(ATP synthase beta subunit) ENC_04180(ATP synthase F1 subcomplex beta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4786(ATP synthase subunit beta,F0F1 ATP synthase subunit beta,F0F1-type ATP synthase, beta subunit,ATP synthase F1, beta subunit,ATP synthase alpha/beta family, nucleotide-binding domain) b3732(F1 sector of membrane-bound ATP synthase, beta subunit) BN373_47741(ATP synthase F1, beta subunit) t3654(ATP synthase beta subunit) SL1344_3832(ATP synthase beta subunit) Cluster322 1 1 1 1 1 1 1 ROD_40091(ATP synthase epsilon subunit) ENC_04170(ATP synthase F1 subcomplex epsilon subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4787(F-ATPase epsilon subunit,F0F1 ATP synthase subunit epsilon,F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit),ATP synthase F1, epsilon subunit,ATP synthase, Delta/Epsilon chain, beta-sandwich domain) b3731(F1 sector of membrane-bound ATP synthase, epsilon subunit) BN373_47731(ATP synthase F1, epsilon subunit) t3655(ATP synthase epsilon subunit) SL1344_3831(ATP synthase epsilon subunit) Cluster323 1 1 1 1 1 1 1 ROD_40101(bifunctional protein GlmU [includes: UDP-N-acetylglucosamine pyrophosphorylase; glucosamine-1-phosphate N-acetyltransferase]) ENC_04160(UDP-N-acetylglucosamine pyrophosphorylase /glucosamine-1-phosphate N-acetyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4789(Bifunctional protein GlmU,bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase,Predicted DNA-binding protein with PD1-like DNA-binding motif,UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase,Bacterial transferase hexapeptide (six repeats)) b3730(fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase) BN373_47711(UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase) t3657(UDP-N-acetylglucosamine pyrophosphorylase) SL1344_3829(UDP-N-acetylglucosamine pyrophosphorylase) Cluster324 1 1 1 1 1 1 1 ROD_40111(glucosamine--fructose-6-phosphate aminotransferase) ENC_04150(glutamine--fructose-6-phosphate transaminase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4790(Glucosamine--fructose-6-phosphate aminotransferase [isomerizing],glucosamine--fructose-6-phosphate aminotransferase,Predicted phosphosugar isomerases,glutamine-fructose-6-phosphate transaminase (isomerizing),SIS domain) b3729(L-glutamine:D-fructose-6-phosphate aminotransferase) BN373_47701(glutamine-fructose-6-phosphate transaminase (isomerizing)) t3658(glucosamine--fructose-6-phosphate aminotransferase) SL1344_3828(glucosamine--fructose-6-phosphate aminotransferase) Cluster325 1 1 1 1 1 1 1 ROD_40131(phosphate ABC transporter, substrate-binding protein) ENC_04090(phosphate ABC transporter substrate-binding protein, PhoT family (TC 3.A.1.7.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4791(Phosphate-binding protein pstS precursor,phosphate ABC transporter periplasmic substrate-binding protein PstS,phosphate ABC transporter, phosphate-binding protein PstS,PBP superfamily domain) b3728(periplasmic phosphate binding protein, high-affinity) BN373_47691(phosphate ABC transporter, periplasmic phosphate-binding protein PstS) t3666(periplasmic phosphate-binding protein) SL1344_3824(periplasmic phosphate-binding protein) Cluster326 1 1 1 1 1 1 1 ROD_40141(phosphate ABC transporter, permease protein) ENC_04080(phosphate ABC transporter membrane protein 1, PhoT family (TC 3.A.1.7.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4792(Phosphate transport system permease protein pstC,phosphate transporter permease subunit PstC,ABC-type phosphate transport system, permease component,phosphate ABC transporter, permease protein PstC,Binding-protein-dependent transport system inner membrane component) b3727(phosphate transporter subunit) BN373_47681(phosphate ABC transporter, permease protein PstC) t3667(phosphate transport system permease protein) SL1344_3823(phosphate transport system permease protein) Cluster327 1 1 1 1 1 1 1 ROD_40151(phosphate ABC transporter, permease protein) ENC_04070(phosphate ABC transporter membrane protein 2, PhoT family (TC 3.A.1.7.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4793(Phosphate transport system permease protein pstA,phosphate transporter permease subunit PtsA,ABC-type phosphate transport system, permease component,phosphate ABC transporter, permease protein PstA,Binding-protein-dependent transport system inner membrane component) b3726(phosphate transporter subunit) BN373_47671(phosphate ABC transporter, permease protein PstA) t3668(phosphate transport system permease protein) SL1344_3822(phosphate transport system permease protein) Cluster328 1 1 1 1 1 1 1 ROD_40161(phosphate ABC transporter, ATP-binding protein) ENC_04060(phosphate ABC transporter ATP-binding protein, PhoT family (TC 3.A.1.7.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4794(Phosphate import ATP-binding protein PstB,phosphate transporter ATP-binding protein,ABC-type spermidine/putrescine transport systems, ATPase components,phosphate ABC transporter, ATP-binding protein,ABC transporter) b3725(phosphate transporter subunit) BN373_47661(phosphate ABC transporter, ATP-binding protein) t3669(phosphate transport ATP-binding protein) SL1344_3821(phosphate transport ATP-binding protein) Cluster329 1 1 1 1 1 1 1 ROD_40201(putative NADPH-dependent FMN reductase) ENC_04010(Predicted flavoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4806(NADPH azoreductase,NAD(P)H-dependent FMN reductase,Predicted flavoprotein,FMN reductase,NADPH-dependent FMN reductase) b3713(chromate reductase, Class I, flavoprotein) BN373_47591(NADPH-dependent FMN reductase) t3673(conserved hypothetical protein) SL1344_3817(conserved hypothetical protein) Cluster330 1 1 1 1 1 1 1 ROD_40211(conserved hypothetical protein) ENC_04000(Phosphopantetheinyl transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4807(holo-(acyl carrier protein) synthase 2) b3712(predicted phosphopantetheinyl transferase, COG2091 family) BN373_47581(conserved hypothetical protein) t3674(conserved hypothetical protein) SL1344_3816(conserved hypothetical protein) Cluster331 1 1 1 1 1 1 1 ROD_40231(probable tRNA modification GTPase) ENC_03970(tRNA modification GTPase trmE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4812(tRNA modification GTPase MnmE,tRNA modification GTPase TrmE,Predicted GTPase,tRNA modification GTPase TrmE,GTP-binding protein TrmE N-terminus) b3706(GTPase) BN373_47541(tRNA modification GTPase TrmE) t3677(thiophene and furan oxidation protein) SL1344_3810(thiophene and furan oxidation protein) Cluster332 1 1 1 1 1 1 1 ROD_40241(inner membrane protein) ENC_03960(protein translocase subunit yidC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4813(Oxa1Ec,membrane protein insertase,membrane protein insertase, YidC/Oxa1 family, N-terminal domain,60Kd inner membrane protein) b3705(membrane protein insertase) BN373_47531(inner membrane protein OxaA) t3678(putative membrane protein) SL1344_3809(putative membrane protein) Cluster333 1 1 1 1 1 1 1 ROD_40251(chromosomal replication initiator protein) ENC_03940(chromosomal replication initiator protein DnaA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4816(Chromosomal replication initiator protein DnaA,chromosomal replication initiation protein,DNA replication protein,chromosomal replication initiator protein DnaA,Bacterial dnaA protein) b3702(chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator) BN373_47491(chromosomal replication initiator protein DnaA) t3681(chromosomal replication initiator protein) SL1344_3805(chromosomal replication initiator protein) Cluster334 1 1 1 1 1 1 1 ROD_40261(DNA polymerase III beta-subunit) ENC_03930(DNA polymerase III, beta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4817(DNA polymerase III subunit beta,DNA polymerase III subunit beta,DNA polymerase III, beta subunit,DNA polymerase III beta subunit, N-terminal domain) b3701(DNA polymerase III, beta subunit) BN373_47481(DNA polymerase III, beta subunit) t3682(DNA polymerase III beta-subunit) SL1344_3804(DNA polymerase III beta-subunit) Cluster335 1 1 1 1 1 1 1 ROD_40271(DNA replication and repair protein) ENC_03920(DNA replication and repair protein RecF) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4818(DNA replication and repair protein recF,recombination protein F,Recombinational DNA repair ATPase (RecF pathway),DNA replication and repair protein RecF,RecF/RecN/SMC N terminal domain) b3700(gap repair protein) BN373_47471(DNA replication and repair protein RecF) t3683(recF protein) SL1344_3803(recF protein) Cluster336 1 1 1 1 1 1 1 ROD_40281(DNA gyrase subunit B) ENC_03910(DNA gyrase subunit B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4819(DNA gyrase subunit B,DNA gyrase subunit B,Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit,DNA gyrase, B subunit,DNA gyrase B) b3699(DNA gyrase, subunit B) BN373_47461(DNA gyrase, B subunit) t3684(DNA gyrase subunit B) SL1344_3802(DNA gyrase subunit B) Cluster337 1 1 1 1 1 1 1 ROD_40291(putative phosphatase) ENC_03880(HAD-superfamily hydrolase, subfamily IIB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4821(Phosphatase YidA,sugar phosphate phosphatase,Predicted hydrolase (HAD superfamily),Cof-like hydrolase,haloacid dehalogenase-like hydrolase) b3697(sugar phosphate phosphatase; substrates include erythrose 4-P and mannose 1-P phosphatase) BN373_47451(sugar-phosphatase, YidA) t3688(conserved hypothetical protein) SL1344_3798(conserved hypothetical protein) Cluster338 1 1 1 1 1 1 1 ROD_40361(conserved hypothetical protein) ENC_03810(Protein of unknown function (DUF3748).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4829(Protein of unknown function (DUF3748)) b3689(conserved protein) BN373_47371(conserved hypothetical protein) t3707(putative ATP/GTP-binding protein) SL1344_3778(putative ATP/GTP-binding protein) Cluster339 1 1 1 1 1 1 1 ROD_40371(putative lipoprotein) ENC_03800(Predicted periplasmic lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4830(hypothetical protein,Predicted periplasmic lipoprotein,Protein of unknown function (DUF1375)) b3688(conserved outer membrane protein) BN373_47361(putative lipoprotein) t3708(putative lipoprotein) SL1344_3777(putative lipoprotein) Cluster340 1 1 1 1 1 1 1 ROD_40401(small heat shock protein B) ENC_03780(Molecular chaperone (small heat shock protein)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4832(16 kDa heat shock protein B,heat shock chaperone IbpB,Hsp20/alpha crystallin family) b3686(heat shock chaperone) BN373_47341(small heat shock protein IbpB) t3710(heat shock protein B) SL1344_3775(heat shock protein B) Cluster341 1 1 1 1 1 1 1 ROD_40411(putative transport protein) ENC_03770(Predicted permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4833(putative transporter,Predicted permease,AspT/YidE/YbjL antiporter duplication domain,Predicted Permease Membrane Region) b3685(predicted transporter) BN373_47321(putative permease) t3711(putative membrane protein) SL1344_3774(putative membrane protein) Cluster342 1 1 1 1 1 1 1 ROD_40511(putative membrane protein) ENC_03720(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4839(Inner membrane protein yidG) b3675(inner membrane protein) BN373_47271(conserved hypothetical protein) t3713(conserved hypothetical protein) SL1344_3772(conserved hypothetical protein) Cluster343 1 1 1 1 1 1 1 ROD_40531(D-serine dehydratase) ENC_03710(D-serine ammonia-lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1350(D-serine dehydratase,D-serine dehydratase,Threonine dehydratase,D-serine ammonia-lyase,Pyridoxal-phosphate dependent enzyme) b2366(D-serine dehydratase) BN373_47251(D-serine ammonia-lyase) t3715(D-serine dehydratase) SL1344_3770(D-serine dehydratase) Cluster344 1 1 1 1 1 1 1 ROD_40541(DsdX permease) ENC_03700(D-serine permease DsdX (TC 2.A.8.1.5)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1351(DsdX permease,permease DsdX,H+/gluconate symporter and related permeases,transporter, gluconate:H+ symporter (GntP) family,GntP family permease) b2365(D-serine permease) BN373_47241(D-serine permease) t3716(DsdX permease) SL1344_3769(DsdX permease) Cluster345 1 1 1 1 1 1 1 ROD_40551(D-serine deaminase activator) ENC_03690(D-serine deaminase transcriptional activator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1352(Gcv operon activator,DNA-binding transcriptional regulator DsdC,D-serine deaminase transcriptional activator,LysR substrate binding domain) b2364(DNA-binding transcriptional dual regulator) BN373_47231(D-serine deaminase transcriptional activator) t3717(D-serine deaminase activator) SL1344_3768(D-serine deaminase activator) Cluster346 1 1 1 1 1 1 1 ROD_40561(multidrug resistance protein D) ENC_03670(Multidrug resistance protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4841(Multidrug resistance protein D,multidrug resistance protein D,Arabinose efflux permease,drug resistance transporter, Bcr/CflA subfamily,Major Facilitator Superfamily) b3673(multidrug efflux system protein) BN373_47221(multidrug resistance protein D) t3719(multidrug resistance protein D) SL1344_3766(multidrug resistance protein D) Cluster347 1 1 1 1 1 1 1 ROD_40601(acetolactate synthase isozyme I large subunit) ENC_03610(acetolactate synthase, large subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4842(Acetolactate synthase isozyme 1 large subunit,acetolactate synthase catalytic subunit,Glyoxylate carboligase,acetolactate synthase, large subunit, biosynthetic type,Thiamine pyrophosphate enzyme, N-terminal TPP binding domain) b3671(acetolactate synthase I, large subunit) BN373_47181(acetolactate synthase, large subunit, isozyme I) t3722(acetohydroxy acid synthase I, small subunit) SL1344_3762(acetohydroxy acid synthase I, small subunit) Cluster348 1 1 1 1 1 1 1 ROD_40611(acetolactate synthase isozyme I small subunit) ENC_03600(acetolactate synthase, small subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4843(Acetolactate synthase isozyme 1 small subunit,acetolactate synthase 1 regulatory subunit,Acetolactate synthase (isozyme II), small (regulatory) subunit,acetolactate synthase, small subunit,ACT domain) b3670(acetolactate synthase I, small subunit) BN373_47171(acetolactate synthase, isozyme I, small subunit) t3723(acetohydroxy acid synthase I, small subunit) SL1344_3761(acetohydroxy acid synthase I, small subunit) Cluster349 1 1 1 1 1 1 1 ROD_40621(two-component system response regulator) ENC_03590(Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4846(Transcriptional regulatory protein uhpA,DNA-binding transcriptional activator UhpA,Response regulator,nitrogen regulation protein NR(I),Bacterial regulatory proteins, luxR family) b3669(DNA-binding response regulator in two-component regulatory system wtih UhpB) BN373_47161(transcriptional regulatory protein UhpA) t3728(two-component system response regulator protein) SL1344_3756(two-component system response regulator protein) Cluster350 1 1 1 1 1 1 1 ROD_40631(two-component system sensor kinase) ENC_03580(Signal transduction histidine kinase, glucose-6-phosphate specific) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4847(Sensor protein degS,sensory histidine kinase UhpB,Signal transduction histidine kinase,MASE1) b3668(sensory histidine kinase in two-component regulatory sytem with UhpA) BN373_47151(sensor protein UhpB) t3729(two-component system sensor histidine kinase) SL1344_3755(two-component system sensor histidine kinase) Cluster351 1 1 1 1 1 1 1 ROD_40641(major facilitator superfamily protein) ENC_03570(phosphoglycerate transporter family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4848(Regulatory protein uhpC,regulatory protein UhpC,Arabinose efflux permease,phosphoglycerate transporter family protein,Major Facilitator Superfamily) b3667(membrane protein regulates uhpT expression) BN373_47141(regulatory protein UhpC) t3730(regulatory protein) SL1344_3754(regulatory protein) Cluster352 1 1 1 1 1 1 1 ROD_40651(hexosephosphate transport protein) ENC_03560(phosphoglycerate transporter family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4849(Hexose phosphate transport protein,sugar phosphate antiporter,phosphoglycerate transporter family protein,Major Facilitator Superfamily) b3666(hexose phosphate transporter) BN373_47131(hexose phosphate transport protein) t3731(hexosephosphate transport protein) SL1344_3753(hexosephosphate transport protein) Cluster353 1 1 1 1 1 1 1 pseudoROD_41121(conserved hypothetical protein (fragment)) ENC_03530(Protein of unknown function (DUF1198).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4852(Protein of unknown function (DUF1198)) b3663(conserved protein) BN373_47121(conserved hypothetical protein) t3732(putative exported protein) SL1344_3752(putative exported protein) Cluster354 1 1 1 1 1 1 1 ROD_41131(purine ribonucleoside efflux pump NepI) ENC_03510(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4855(Purine ribonucleoside efflux pump nepI,ribonucleoside transporter,Arabinose efflux permease,multidrug resistance protein,Major Facilitator Superfamily) b3662(predicted transporter) BN373_47091(nucleoside efflux permease) t3742(putative inner membrane transport protein) pseudoSL1344_3741(putative inner membrane transport protein (pseudogene)) Cluster355 1 1 1 1 1 1 1 ROD_41211(putative membrane protein) ENC_03500(Predicted permease, DMT superfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4858(Uncharacterized inner membrane transporter yicL,putative DMT superfamily transporter inner membrane protein,Predicted permease, DMT superfamily,carboxylate/amino acid/amine transporter,EamA-like transporter family) b3660(predicted inner membrane protein) BN373_46871(putative transport protein) t3753(putative membrane protein) SL1344_3730(putative membrane protein) Cluster356 1 1 1 1 1 1 1 ROD_25061(N-acetylmuramic acid 6-phosphate etherase) ENC_37010(N-acetylmuramic acid 6-phosphate etherase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1292(N-acetylmuramic acid 6-phosphate etherase,N-acetylmuramic acid-6-phosphate etherase,Predicted phosphosugar isomerases,N-acetylmuramic acid 6-phosphate etherase,SIS domain) b2428(N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase) BN373_46851(N-acetylmuramic acid 6-phosphate etherase) t0286(putative phophosugar binding protein) SL1344_2533(putative phophosugar binding protein) Cluster357 1 1 1 1 1 1 1 ROD_41591(putative carbohydrate transporter) ENC_02810(sugar (Glycoside-Pentoside-Hexuronide) transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.20(Inner membrane symporter yicJ,putative transporter,Arabinose efflux permease,sugar (Glycoside-Pentoside-Hexuronide) transporter) b3657(predicted transporter) BN373_46611(sugar transporter, glycoside-pentoside-hexuronide (GPH):cation symporter family) t3769(sodium:galactoside family symporter) SL1344_3716(sodium:galactoside family symporter) Cluster358 1 1 1 1 1 1 1 ROD_41601(putative glycosyl hydrolase) ENC_02800(Alpha-glucosidases, family 31 of glycosyl hydrolases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.21(Alpha-xylosidase,putative alpha-glucosidase,Alpha-galactosidase,Glycosyl hydrolases family 31) b3656(predicted alpha-glucosidase) BN373_46601(alpha-xylosidase) t3770(putative glycosyl hydrolase) SL1344_3715(putative glycosyl hydrolase) Cluster359 1 1 1 1 1 1 1 ROD_41621(putative purine permease) ENC_02780(uracil-xanthine permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.31(Xanthine permease XanP,uracil transporter,uracil-xanthine permease,Permease family) b3654(xanthine permease) BN373_46551(xanthine permease) t3772(putative purine permease) SL1344_3713(putative purine permease) Cluster360 1 1 1 1 1 1 1 ROD_41631(sodium/glutamate symport carrier protein (glutamate permease)) ENC_02770(sodium--glutamate symport carrier (gltS)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.32(Glutamate permease,sodium/glutamate symporter,Sodium/glutamate symporter) b3653(glutamate transporter) BN373_46541(sodium/glutamate symporter) t3773(glutamate permease) SL1344_3712(glutamate permease) Cluster361 1 1 1 1 1 1 1 ROD_38221(glycerol kinase) ENC_00860(glycerol kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4576(Glycerol kinase,glycerol kinase,Pentose-5-phosphate-3-epimerase,glycerol kinase,FGGY family of carbohydrate kinases, N-terminal domain) b3926(glycerol kinase) BN373_46531(glycerol kinase) t3532(glycerol kinase) SL1344_4035(glycerol kinase) Cluster362 1 1 1 1 1 1 1 ROD_38211(glycerol uptake facilitator protein) ENC_00870(MIP family channel proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4575(Aquaglyceroporin,aquaporin Z,MIP family channel proteins,Major intrinsic protein) b3927(glycerol facilitator) BN373_46521(glycerol uptake facilitator protein) t3531(glycerol uptake facilitator protein) SL1344_4036(glycerol uptake facilitator protein) Cluster363 1 1 1 1 1 1 1 ROD_38331(sulfate-binding protein (sulfate starvation-induced protein 2)) ENC_00780(sulfate/thiosulfate-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4585(Sulfate starvation-induced protein 2,sulfate transporter subunit,ABC-type sulfate transport system, periplasmic component,sulfate ABC transporter, sulfate-binding protein,Bacterial extracellular solute-binding protein) b3917(sulfate transporter subunit) BN373_46501(sulfate-binding protein) t3556(periplasmic sulphate binding protein) SL1344_4012(periplasmic sulphate binding protein) Cluster364 1 1 1 1 1 1 1 ROD_38281(triosephosphate isomerase) ENC_00810(triosephosphate isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4583(Triosephosphate isomerase,triosephosphate isomerase,triose-phosphate isomerase,Triosephosphate isomerase) b3919(triosephosphate isomerase) BN373_46471(triosephosphate isomerase) t3537(triosephosphate isomerase) SL1344_4030(triosephosphate isomerase) Cluster365 1 1 1 1 1 1 1 ROD_38271(putative exported protein) ENC_00820(Protein of unknown function (DUF1454).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4582(Protein of unknown function (DUF1454)) b3920(conserved protein) BN373_46461(conserved hypothetical protein) t3536(conserved hypothetical protein) SL1344_4031(conserved hypothetical protein) Cluster366 1 1 1 1 1 1 1 ROD_38261(putative membrane protein) ENC_00830(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4581(Predicted membrane protein,Protein of unknown function (DUF805)) b3921(predicted inner membrane protein, DUF805 family) BN373_46451(conserved hypothetical protein) t3535(putative membrane protein) SL1344_4032(putative membrane protein) Cluster367 1 1 1 1 1 1 1 ROD_38241(ferredoxin--NADP reductase) ENC_00840(Flavodoxin reductases (ferredoxin-NADPH reductases) family 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4578(Ferredoxin--NADP reductase,ferredoxin-NADP reductase,phenylacetate-CoA oxygenase/reductase, PaaK subunit,Oxidoreductase NAD-binding domain) b3924(ferredoxin-NADP reductase) BN373_46441(ferredoxin--NADP(+) reductase) t3534(ferredoxin--NADP reductase) SL1344_4033(ferredoxin--NADP reductase) Cluster368 1 1 1 1 1 1 1 ROD_38231(fructose-1,6-bisphosphatase class II) ENC_00850(fructose-1,6-bisphosphatase, class II) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4577(Fructose-1,6-bisphosphatase 1 class 2,fructose 1,6-bisphosphatase II,Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins,fructose-1,6-bisphosphatase, class II,Bacterial fructose-1,6-bisphosphatase, glpX-encoded) b3925(fructose 1,6-bisphosphatase II) BN373_46431(fructose-1,6-bisphosphatase, class II) t3533(putative glycerol metabolic protein) SL1344_4034(putative glycerol metabolic protein) Cluster369 1 1 1 1 1 1 1 ROD_41641(ATP-dependent DNA helicase) ENC_02760(ATP-dependent DNA helicase RecG) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.33(ATP-dependent DNA helicase recG,ATP-dependent DNA helicase RecG,Superfamily II helicase,ATP-dependent DNA helicase RecG,DEAD/DEAH box helicase) b3652(ATP-dependent DNA helicase) BN373_46421(ATP-dependent DNA helicase RecG) t3774(ATP-dependent DNA helicase) SL1344_3710(ATP-dependent DNA helicase) Cluster370 1 1 1 1 1 1 1 ROD_41651(tRNA (guanosine-2'-O)-methyltransferase) ENC_02750(rRNA methylases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.34(tRNA (guanosine(18)-2'-O)-methyltransferase,tRNA guanosine-2'-O-methyltransferase,RNA methyltransferase, TrmH family, group 3,SpoU rRNA Methylase family) b3651(tRNA mG18-2'-O-methyltransferase, SAM-dependen) BN373_46411(tRNA guanosine-2'-O-methyltransferase) t3775(tRNA (guanosine-2'-O)-methyltransferase) SL1344_3709(tRNA (guanosine-2'-O)-methyltransferase) Cluster371 1 1 1 1 1 1 1 ROD_41671(DNA-directed RNA polymerase omega chain) ENC_02730(DNA-directed RNA polymerase subunit omega) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.36(DNA-directed RNA polymerase subunit omega,DNA-directed RNA polymerase subunit omega,DNA-directed RNA polymerase, omega subunit,RNA polymerase Rpb6) b3649(RNA polymerase, omega subunit) BN373_46391(DNA-directed RNA polymerase, omega subunit) t3777(DNA-directed RNA polymerase omega chain) SL1344_3707(DNA-directed RNA polymerase omega chain) Cluster372 1 1 1 1 1 1 1 ROD_41681(guanylate kinase) ENC_02720(guanylate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.37(Guanylate kinase,guanylate kinase,Guanylate kinase,guanylate kinase,Guanylate kinase) b3648(guanylate kinase) BN373_46381(guanylate kinase) t3778(5'guanylate kinase) SL1344_3706(5'guanylate kinase) Cluster373 1 1 1 1 1 1 1 pseudoROD_41701(putative membrane protein (pseudogene)) ENC_02640(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.39(hypothetical protein,hypothetical protein,Predicted membrane protein,UPF0126 domain) b3646(inner membrane protein, UPF0126 family) BN373_46361(putative membrane protein) t3780(putative membrane protein) SL1344_3704(putative membrane protein) Cluster374 1 1 1 1 1 1 1 ROD_41711(conserved hypothetical protein) ENC_02630(conserved hypothetical protein TIGR00255) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.40(hypothetical protein,hypothetical protein,conserved hypothetical protein,YicC-like family, N-terminal region) b3644(conserved protein, UPF0701 family) BN373_46321(conserved hypothetical protein TIGR00255) t3783(conserved hypothetical protein) SL1344_3701(conserved hypothetical protein) Cluster375 1 1 1 1 1 1 1 ROD_41721(ribonuclease PH) ENC_02620(ribonuclease PH) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.41(Ribonuclease PH,ribonuclease PH,Xanthosine triphosphate pyrophosphatase,ribonuclease PH,3' exoribonuclease family, domain 1) b3643(defective ribonuclease PH) BN373_46271(ribonuclease PH) t3784(ribonuclease PH) SL1344_3700(RNase PH) Cluster376 1 1 1 1 1 1 1 ROD_41731(orotate phosphoribosyltransferase) ENC_02610(orotate phosphoribosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.42(Orotate phosphoribosyltransferase,orotate phosphoribosyltransferase,orotate phosphoribosyltransferase,Phosphoribosyl transferase domain) b3642(orotate phosphoribosyltransferase) BN373_46261(orotate phosphoribosyltransferase) t3785(orotate phosphoribosyltransferase) SL1344_3699(orotate phosphoribosyltransferase) Cluster377 1 1 1 1 1 1 1 ROD_41741(TetR-family transcriptional regulator) ENC_02600(cell division inhibitor SlmA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.43(Synthetically lethal with a defective Min system protein A,division inhibitor protein,Bacterial regulatory proteins, tetR family) b3641(DNA-binding anti-FtsZ division inhibitor) BN373_46241(transcriptional regulator domain protein, TetR family) t3786(putative TetR-family transcriptional regulator) SL1344_3698(putative TetR-family transcriptional regulator) Cluster378 1 1 1 1 1 1 1 ROD_41751(deoxyuridine 5'-triphosphate nucleotidohydrolase) ENC_02590(deoxyuridine 5'-triphosphate nucleotidohydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.44(Deoxyuridine 5'-triphosphate nucleotidohydrolase,deoxyuridine 5'-triphosphate nucleotidohydrolase,dUTP diphosphatase,dUTPase) b3640(deoxyuridinetriphosphatase) BN373_46231(dUTP diphosphatase) t3787(deoxyuridine 5'-triphosphate nucleotidohydrolase) SL1344_3697(deoxyuridine 5'-triphosphate nucleotidohydrolase) Cluster379 1 1 1 1 1 1 1 ROD_41761(coenzyme A biosynthesis bifunctional protein [includes: phosphopantothenoylcysteine decarboxylase; phosphopantothenate-cysteine ligase]) ENC_02580(Phosphopantothenate-cysteine ligase /Phosphopantothenoylcysteine decarboxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.45(DNA/pantothenate metabolism flavoprotein,bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase,Phosphopantothenoylcysteine synthetase/decarboxylase,phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase,DNA / pantothenate metabolism flavoprotein) b3639(fused 4'-phosphopantothenoylcysteine decarboxylase/phosphopantothenoylcysteine synthetase, FMN-binding) BN373_46221(phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase) t3788(conserved hypothetical protein) SL1344_3696(conserved hypothetical protein) Cluster380 1 1 1 1 1 1 1 ROD_41771(DNA repair protein) ENC_02570(DNA replication and repair protein RadC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.46(hypothetical protein,hypothetical protein,DNA repair protein RadC,Protein of unknown function (DUF2466)) b3638(conserved protein, UPF0758 family; not radC) BN373_46211(DNA repair protein RadC) t3789(putative DNA repair protein) SL1344_3695(putative DNA repair protein) Cluster381 1 1 1 1 1 1 1 ROD_41791(50S ribosomal subunit protein L33) ENC_02550(LSU ribosomal protein L33P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.48(50S ribosomal protein L33,50S ribosomal protein L33,Ribosomal protein L33,ribosomal protein L33,Ribosomal protein L33) b3636(50S ribosomal subunit protein L33) BN373_46191(ribosomal protein L33) t3791(50S ribosomal subunit protein L33) SL1344_3693(50S ribosomal subunit protein L33) Cluster382 1 1 1 1 1 1 1 ROD_41811(formamidopyrimidine-DNA glycosylase) ENC_02540(DNA-(apurinic or apyrimidinic site) lyase /Formamidopyrimidine-DNA glycosylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.49(Formamidopyrimidine-DNA glycosylase,formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase,formamidopyrimidine-DNA glycosylase,Formamidopyrimidine-DNA glycosylase N-terminal domain) b3635(formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase) BN373_46181(formamidopyrimidine-DNA glycosylase) t3792(formamidopyrimidine-DNA glycosylase) SL1344_3692(formamidopyrimidine-DNA glycosylase) Cluster383 1 1 1 1 1 1 1 ROD_41821(phosphopantetheine adenylyltransferase) ENC_02530(Phosphopantetheine adenylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.50(Phosphopantetheine adenylyltransferase,phosphopantetheine adenylyltransferase,Predicted ATPase/kinase involved in NAD metabolism,pantetheine-phosphate adenylyltransferase,Cytidylyltransferase) b3634(pantetheine-phosphate adenylyltransferase) BN373_46171(pantetheine-phosphate adenylyltransferase) t3793(phosphopantetheine adenylyltransferase) SL1344_3691(phosphopantetheine adenylyltransferase) Cluster384 1 1 1 1 1 1 1 ROD_42011(putative glycosyl transferase) ENC_02500(Glycosyltransferases involved in cell wall biogenesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.69(Hyaluronan synthase,putative glycosyl transferase,Predicted glycosyl hydrolase,poly-beta-1,6 N-acetyl-D-glucosamine synthase,Glycosyl transferase family 2) b3615(predicted glycosyl transferase) BN373_46141(glycosyl transferase, group 2 family protein) t3812(putative glycosyl transferase) SL1344_3673(putative glycosyltransferase) Cluster385 1 1 1 1 1 1 1 ROD_41851(heptosyl-III-transferase) ENC_02470(lipopolysaccharide heptosyltransferase III, putative) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.53(Lipopolysaccharide core heptosyltransferase rfaQ,lipopolysaccharide core biosynthesis protein,ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase,putative lipopolysaccharide heptosyltransferase III,Glycosyltransferase family 9 (heptosyltransferase)) b3632(lipopolysaccharide core biosynthesis protein) BN373_46111(lipopolysaccharide core biosynthesis glycosyltransferase RfaQ) t3795(lipopolysaccharide core biosynthesis protein) SL1344_3689(lipopolysaccharide core biosynthesis protein) Cluster386 1 1 1 1 1 1 1 ROD_21801(putative colanic acid biosynthesis glycosyl transferase) ENC_41220(Glycosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1668(GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase,colanic acid biosynthesis glycosyltransferase WcaL,Glycogen synthase,colanic acid biosynthesis glycosyltransferase WcaL,Glycosyl transferases group 1) b2044(predicted glycosyl transferase) BN373_46071(group 1 glycosyl transferase) t0772(putative glycosyl transferase) SL1344_2077(putative glycosyltransferase) Cluster387 1 1 1 1 1 1 1 ROD_41961(lipopolysaccharide heptosyltransferase 1) ENC_02400(lipopolysaccharide heptosyltransferase I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.64(Lipopolysaccharide heptosyltransferase 1,ADP-heptose:LPS heptosyl transferase I,lipopolysaccharide heptosyltransferase I,Glycosyltransferase family 9 (heptosyltransferase)) b3621(ADP-heptose:LPS heptosyl transferase I) BN373_46061(lipopolysaccharide heptosyltransferase I) t3807(lipopolysaccharide heptosyltransferase-1) SL1344_3678(lipopolysaccharide heptosyltransferase-1) Cluster388 1 1 1 1 1 1 1 ROD_41971(ADP-heptose-LPS heptosyltransferase II) ENC_02390(lipopolysaccharide heptosyltransferase II) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.65(ADP-heptose--LPS heptosyltransferase 2,ADP-heptose:LPS heptosyltransferase II,lipopolysaccharide heptosyltransferase II,Glycosyltransferase family 9 (heptosyltransferase)) b3620(ADP-heptose:LPS heptosyltransferase II) BN373_46051(lipopolysaccharide heptosyltransferase II) t3808(ADP-heptose-LPS heptosyltransferase II) SL1344_3677(ADP-heptose-LPS heptosyltransferase II) Cluster389 1 1 1 1 1 1 1 ROD_41981(ADP-L-glycero-D-manno-heptose-6-epimerase) ENC_02380(ADP-L-glycero-D-manno-heptose-6-epimerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.66(ADP-L-glycero-D-manno-heptose-6-epimerase,ADP-L-g lycero-D-mannoheptose-6-epimerase,Lipid A core - O-antigen ligase and related enzymes,ADP-glyceromanno-heptose 6-epimerase,NAD dependent epimerase/dehydratase family) b3619(ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding) BN373_46041(ADP-glyceromanno-heptose 6-epimerase) t3809(ADP-L-Glycero-D-mannoheptose-6-epimerase) SL1344_3676(ADP-L-Glycero-D-mannoheptose-6-epimerase) Cluster390 1 1 1 1 1 1 1 ROD_41991(2-amino-3-ketobutyrate coenzyme A ligase) ENC_02370(2-amino-3-ketobutyrate coenzyme A ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.67(2-amino-3-ketobutyrate coenzyme A ligase,2-amino-3-ketobutyrate coenzyme A ligase,7-keto-8-aminopelargonate synthetase and related enzymes,2-amino-3-ketobutyrate coenzyme A ligase,Aminotransferase class I and II) b3617(glycine C-acetyltransferase) BN373_46031(2-amino-3-ketobutyrate coenzyme A ligase) t3810(2-amino-3-ketobutyrate coenzyme A ligase) SL1344_3675(2-amino-3-ketobutyrate coenzyme A ligase) Cluster391 1 1 1 1 1 1 1 ROD_42001(L-threonine 3-dehydrogenase) ENC_02360(L-threonine 3-dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.68(L-threonine 3-dehydrogenase,L-threonine 3-dehydrogenase,L-threonine 3-dehydrogenase,Alcohol dehydrogenase GroES-like domain) b3616(threonine 3-dehydrogenase, NAD(P)-binding) BN373_46021(L-threonine 3-dehydrogenase) t3811(threonine 3-dehydrogenase) SL1344_3674(threonine 3-dehydrogenase) Cluster392 1 1 1 1 1 1 1 ROD_42041(2,3-bisphosphoglycerate-independent phosphoglycerate mutase) ENC_02300(phosphoglycerate mutase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.72(2,3-bisphosphoglycerate-independent phosphoglycerate mutase,phosphoglyceromutase,Predicted phosphoglycerate mutase, AP superfamily,2,3-bisphosphoglycerate-independent phosphoglycerate mutase,Metalloenzyme superfamily) b3612(phosphoglycero mutase III, cofactor-independent) BN373_45981(2,3-bisphosphoglycerate-independent phosphoglycerate mutase) t3815(2,3-bisphosphoglycerate-independent phosphoglycerate mutase) SL1344_3670(2,3-bisphosphoglycerate-independent phosphoglycerate mutase) Cluster393 1 1 1 1 1 1 1 ROD_42051(putative rhodanase-like exported protein) ENC_02290(Rhodanese-related sulfurtransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.73(hypothetical protein,molybdopterin biosynthesis protein MoeB,Uncharacterized conserved protein,Rhodanese-like domain) b3611(predicted rhodanese-related sulfurtransferase) BN373_45971(rhodanese domain protein) t3816(putative secreted protein) SL1344_3669(putative secreted protein) Cluster394 1 1 1 1 1 1 1 ROD_42061(glutaredoxin 3) ENC_02280(Glutaredoxin, GrxC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.74(Glutaredoxin-3,glutaredoxin 3,glutaredoxin 3,Glutaredoxin) b3610(glutaredoxin 3) BN373_45961(glutaredoxin 3) t3817(glutaredoxin 3) SL1344_3668(glutaredoxin 3) Cluster395 1 1 1 1 1 1 1 ROD_42071(protein-export protein SecB) ENC_02270(protein translocase subunit secB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.75(Protein-export protein SecB,preprotein translocase subunit SecB,protein-export chaperone SecB,Preprotein translocase subunit SecB) b3609(protein export chaperone) BN373_45951(protein-export chaperone SecB) t3818(export protein SecB) SL1344_3667(protein-export protein SecB) Cluster396 1 1 1 1 1 1 1 ROD_42081(glycerol-3-phosphate dehydrogenase) ENC_02260(glycerol 3-phosphate dehydrogenase (NAD(P)+)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.76(Glycerol-3-phosphate dehydrogenase [NAD(P)+],NAD(P)H-dependent glycerol-3-phosphate dehydrogenase,Glycerol-3-phosphate dehydrogenase,glycerol-3-phosphate dehydrogenase (NAD(+)),NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus) b3608(glycerol-3-phosphate dehydrogenase (NAD+)) BN373_45941(NAD-dependent glycerol-3-phosphate dehydrogenase) t3819(glycerol-3-phosphate dehydrogenase) SL1344_3666(glycerol-3-phosphate dehydrogenase) Cluster397 1 1 1 1 1 1 1 ROD_42091(serine acetyltransferase) ENC_02250(serine O-acetyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.77(Serine acetyltransferase,serine acetyltransferase,Acetyltransferase (isoleucine patch superfamily),serine O-acetyltransferase,Serine acetyltransferase, N-terminal) b3607(serine acetyltransferase) BN373_45931(serine O-acetyltransferase) t3820(serine acetyltransferase) SL1344_3665(serine acetyltransferase) Cluster398 1 1 1 1 1 1 1 ROD_42131(putative RNA-methyltransferase) ENC_47760(rRNA methylase, putative, group 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.78(tRNA (cytidine(34)-2'-O)-methyltransferase,putative rRNA methylase,tRNA (cytidine(34)-2'-O)-methyltransferase,SpoU rRNA Methylase family) b3606(tRNA Leu mC34/mU34 2'-O-methyltransferase, SAM-dependent) BN373_45921(RNA methyltransferase, TrmH family, group 2) t3824(putative RNA methyltransferase) SL1344_3660(putative RNA-methyltransferase) Cluster399 1 1 1 1 1 1 1 pseudoROD_42151(L-lactate dehydrogenase (pseudogene)) ENC_47740(L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.79(L-lactate dehydrogenase [cytochrome],L-lactate dehydrogenase,L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases,heme/flavin dehydrogenase, mycofactocin system,FMN-dependent dehydrogenase) b3605(L-lactate dehydrogenase, FMN-linked) BN373_45911(L-lactate dehydrogenase (cytochrome)) t3825(putative L-lactate dehydrogenase) SL1344_3659(putative L-lactate dehydrogenase) Cluster400 1 1 1 1 1 1 1 ROD_42161(putative L-lactate dehydrogenase operon regulator) ENC_47730(transcriptional regulator, GntR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.80(Pyruvate dehydrogenase complex repressor,DNA-binding transcriptional repressor LldR,Transcriptional regulators,phosphonate metabolism transcriptional regulator PhnF,FCD domain) b3604(dual role activator/repressor for lldPRD operon) BN373_45901(putative L-lactate dehydrogenase operon regulatory protein LldR) t3826(putative L-lactate dehydrogenase operon regulator) SL1344_3658(putative L-lactate dehydrogenase operon regulator) Cluster401 1 1 1 1 1 1 1 ROD_42181(conserved hypothetical protein) ENC_47660(Protein of unknown function (DUF2810).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.84(hypothetical protein,hypothetical protein,Protein of unknown function (DUF2810)) b3602(conserved protein, ribosome-associated) BN373_45881(conserved hypothetical protein) t3830(conserved hypothetical protein) SL1344_3654(conserved hypothetical protein) Cluster402 1 1 1 1 1 1 1 ROD_42201(mannitol operon repressor) ENC_47650(mannitol repressor, MtlR) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.86(Mannitol repressor protein,mannitol repressor protein,Mannitol repressor) b3601(mannitol operon repressor) BN373_45861(mannitol operon repressor) t3832(mannitol operon repressor) SL1344_3652(mannitol operon repressor (mannitol repressor protein)) Cluster403 1 1 1 1 1 1 1 ROD_42211(mannitol-1-phosphate 5-dehydrogenase) ENC_47640(D-mannitol 1-phosphate 5-dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.87(Mannitol-1-phosphate 5-dehydrogenase,mannitol-1-phosphate 5-dehydrogenase,Mannitol-1-phosphate/altronate dehydrogenases,Mannitol dehydrogenase C-terminal domain) b3600(mannitol-1-phosphate dehydrogenase, NAD-dependent) BN373_45851(mannitol-1-phosphate 5-dehydrogenase) t3833(mannitol-1-phosphate dehydrogenase) SL1344_3651(mannitol-1-phosphate dehydrogenase) Cluster404 1 1 1 1 1 1 1 ROD_42221(mannitol-specific PTS system EIICBA component) ENC_47630(PTS system D-mannitol-specific IIA component, Fru family (TC 4.A.2.1.2)/PTS system D-mannitol-specific IIB component, Fru family (TC 4.A.2.1.2)/PTS system D-mannitol-specific IIC component, Fru family (TC 4.A.2.1.2)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.88(EIICBA-Mtl,PTS system mannitol-specific transporter subunit IICBA,Phosphotransferase system, galactitol-specific IIB component,PTS system, mannitol-specific IIC component,Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2) b3599(fused mannitol-specific PTS enzymes: IIA components/IIB components/IIC components) BN373_45841(PTS system mannitol-specific EIICBA component) t3834(mannitol-specific enzyme II of phosphotransferase system) SL1344_3650(mannitol-specific enzyme II of phosphotransferase system) Cluster405 1 1 1 1 1 1 1 ROD_42251(putative glutathione S-transferase) ENC_47620(Glutathione S-transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.91(Glutathione S-transferase,putative glutathione S-transferase,maleylacetoacetate isomerase,Glutathione S-transferase, C-terminal domain) b3592(glutathione S-transferase homolog) BN373_45831(glutathione S-transferase) t3835(putative glutathione transferase) SL1344_3649(putative glutathione transferase) Cluster406 1 1 1 1 1 1 1 ROD_42261(L-seryl-tRNA(Ser) selenium transferase) ENC_47610(L-seryl-tRNA(Sec) selenium transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.92(L-seryl-tRNA(Sec) selenium transferase,selenocysteine synthase,Selenocysteine synthase [seryl-tRNASer selenium transferase],L-seryl-tRNA selenium transferase,L-seryl-tRNA selenium transferase) b3591(selenocysteine synthase) BN373_45821(L-seryl-tRNA selenium transferase) t3836(L-seryl-tRNA(Ser) selenium transferase) SL1344_3648(L-seryl-tRNA(Ser) selenium transferase) Cluster407 1 1 1 1 1 1 1 ROD_42371(valine--pyruvate aminotransferase) ENC_47410(valine-pyruvate aminotransferase apoenzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.112(Aspartate aminotransferase,valine--pyruvate transaminase,Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase,threonine-phosphate decarboxylase,Aminotransferase class I and II) b3572(valine-pyruvate aminotransferase 1) BN373_45791(valine--pyruvate transaminase) t3854(valine--pyruvate aminotransferase) SL1344_3630(valine--pyruvate aminotransferase) Cluster408 1 1 1 1 1 1 1 ROD_42381(alpha-amylase) ENC_47400(Glycosidases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.113(Alpha-amylase precursor,alpha-amylase,Maltooligosyl trehalose synthase,trehalose synthase,Alpha amylase, catalytic domain) b3571(alpha-amylase) BN373_45781(alpha-amylase, periplasmic) t3855(alpha-amylase) SL1344_3629(alpha-amylase) Cluster409 1 1 1 1 1 1 1 ROD_42391(putative endo-beta-N-acetylglucosaminidase) ENC_47390(Uncharacterized FlgJ-related protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.114(hypothetical protein,Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase) b3570(conserved protein) BN373_45771(protein bax) t3856(putative exported amidase) SL1344_3628(putative exported amidase) Cluster410 1 1 1 1 1 1 1 ROD_42401(xylose operon regulatory protein) ENC_47380(transcriptional regulator, AraC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.115(Bacillibactin transport regulator,DNA-binding transcriptional regulator AraC,Adenosine deaminase,YSIRK-targeted surface antigen transcriptional regulator,Bacterial regulatory helix-turn-helix proteins, AraC family) b3569(DNA-binding transcriptional activator, xylose-binding) BN373_45761(xylose operon regulatory protein) t3857(xylose operon regulatory protein) SL1344_3627(xylose operon regulatory protein) Cluster411 1 1 1 1 1 1 1 ROD_42421(xylulose kinase) ENC_47330(xylulokinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.120(Xylulose kinase,xylulokinase,Pentose-5-phosphate-3-epimerase,xylulok inase,FGGY family of carbohydrate kinases, N-terminal domain) b3564(xylulokinase) BN373_45711(xylulokinase) t3859(xylulose kinase) SL1344_3625(xylulose kinase) Cluster412 1 1 1 1 1 1 1 ROD_42451(putative lipoprotein) ENC_47310(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.124(hypothetical protein) b4553(predicted protein) BN373_45671(conserved hypothetical protein) t3862(putative lipoprotein) SL1344_3622(putative lipoprotein) Cluster413 1 1 1 1 1 1 1 ROD_42461(glycine-tRNA synthetase, alpha subunit) ENC_47300(glycyl-tRNA synthetase alpha chain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.125(Glycine--tRNA ligase alpha subunit,glycyl-tRNA synthetase subunit alpha,glycine--tRNA ligase, alpha subunit,Glycyl-tRNA synthetase alpha subunit) b3560(glycine tRNA synthetase, alpha subunit) BN373_45661(glycyl-tRNA synthetase, alpha subunit) t3863(glycine-tRNA synthetase, alpha subunit) SL1344_3621(glycine-tRNA synthetase, alpha subunit) Cluster414 1 1 1 1 1 1 1 ROD_42471(glycine-tRNA synthetase, beta subunit) ENC_47290(glycyl-tRNA synthetase beta chain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.126(Glycine--tRNA ligase beta subunit,glycyl-tRNA synthetase subunit beta,glycine--tRNA ligase, beta subunit,Glycyl-tRNA synthetase beta subunit) b3559(glycine tRNA synthetase, beta subunit) BN373_45651(glycyl-tRNA synthetase, beta subunit) t3864(glycine-tRNA synthetase, beta subunit) SL1344_3620(glycine-tRNA synthetase, beta subunit) Cluster415 1 1 1 1 1 1 1 ROD_42501(putative transcriptional regulator) ENC_01670(Predicted transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.129(putative transcriptional regulator,putative zinc finger/helix-turn-helix protein, YgiT family) b3555(predicted transcriptional regulator, HTH_CROC1 family) BN373_45541(conserved hypothetical protein) t3871(putative DNA-binding protein) SL1344_3614(putative HTH-type transcriptional regulator) Cluster416 1 1 1 1 1 1 1 ROD_42521(putative lipoprotein) ENC_01660(Protein of unknown function (DUF3053).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.130(Protein of unknown function (DUF3053)) b3554(conserved protein) BN373_45521(putative lipoprotein) t3872(conserved hypothetical protein) SL1344_3613(conserved hypothetical protein) Cluster417 1 1 1 1 1 1 1 ROD_42531(2-ketogluconate reductase) ENC_01640(Lactate dehydrogenase and related dehydrogenases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.131(Glyoxylate/hydroxypyruvate reductase B,bifunctional glyoxylate/hydroxypyruvate reductase B,Phosphoserine aminotransferase,phosphoglycerate dehydrogenase,D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain) b3553(glyoxylate/hydroxypyruvate reductase B) BN373_45511(2-ketogluconate reductase) t3873(putative 2-hydroxyacid dehydrogenase) SL1344_3612(putative 2-hydroxyacid dehydrogenase) Cluster418 1 1 1 1 1 1 1 ROD_42551(putative outer membrane protein) ENC_01590(Outer membrane protein and related peptidoglycan-associated (lipo)proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.132(Inner membrane lipoprotein YiaD precursor,putative outer membrane lipoprotein,Outer membrane protein and related peptidoglycan-associated (lipo)proteins,type VI secretion system OmpA/MotB family protein,OmpA family) b3552(multicopy suppressor of bamB; outer membrane lipoprotein) BN373_45461(OmpA family protein) t3874(putative outer membrane protein) SL1344_3611(putative outer membrane protein) Cluster419 1 1 1 1 1 1 1 ROD_42571(putative acetyltransferase) ENC_01570(Acetyltransferases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.134(Uncharacterized N-acetyltransferase YjaB,putative acetyltransferase,ribosomal-protein-alanine acetyltransferase,Acetyltransferase (GNAT) family) b3550(predicted acyltransferase with acyl-CoA N-acyltransferase domain) BN373_45441(acetyltransferase, GNAT family) t3876(putative acetyltransferase) SL1344_3609(putative acetyltransferase) Cluster420 1 1 1 1 1 1 1 pseudoROD_42581(3-methyladenine DNA glycosylase I (pseudogene)) ENC_01560(DNA-3-methyladenine glycosylase I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.135(DNA-3-methyladenine glycosylase 1,3-methyl-adenine DNA glycosylase I,3-methyladenine DNA glycosylase,DNA-3-methyladenine glycosylase I,Methyladenine glycosylase) b3549(3-methyl-adenine DNA glycosylase I, constitutive) BN373_45431(DNA-3-methyladenine glycosylase I) t3877(3-methyladenine DNA glycosylase I) SL1344_3608(3-methyladenine DNA glycosylase I, constitutive) Cluster421 1 1 1 1 1 1 1 ROD_42591(putative exported protein) ENC_01550(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.136(Lipase 1 precursor,Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion,Autotransporter beta-domain) b3548(conserved protein) BN373_45421(conserved hypothetical protein) t3878(putative membrane protein) SL1344_3607(putative lipoprotein) Cluster422 1 1 1 1 1 1 1 ROD_42601(major facilitator superfamily protein) ENC_01540(Oxalate/Formate Antiporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.137(Inner membrane protein yhjX,putative sialic acid transporter,Arabinose efflux permease,oxalate/formate antiporter family transporter,Major Facilitator Superfamily) b3547(Inner membrane protein, predicted oxalate-formate antiporter) BN373_45411(transporter, major facilitator family) t0283(putative transmembrane transport protein) SL1344_2536(putative transmembrane transport protein) Cluster423 1 1 1 1 1 1 1 ROD_42621(phosphoethanolamine transferase) ENC_01530(phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.138(Phosphoethanolamine transferase eptB,phosphoethanolamine transferase,Predicted membrane-associated, metal-dependent hydrolase,Sulfatase) b3546(KDO phosphoethanolamine transferase, Ca(2+)-inducible) BN373_45401(membrane-associated sulfatase) t3879(putative membrane protein) SL1344_3600(putative membrane protein) Cluster424 1 1 1 1 1 1 1 ROD_42641(dipeptide ABC transporter, permease protein) ENC_01510(ABC-type dipeptide/oligopeptide/nickel transport systems, permease components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.141(Dipeptide transport system permease protein dppB,dipeptide transporter permease DppB,nickel ABC transporter, permease subunit NikB,Binding-protein-dependent transport system inner membrane component) b3543(dipeptide/heme transporter) BN373_45361(dipeptide ABC transporter, permease protein DppB) t3886(dipeptide transport system permease protein DppB) SL1344_3595(dipeptide transport system permease protein DppB) Cluster425 1 1 1 1 1 1 1 ROD_42651(dipeptide ABC transporter, permease protein) ENC_01500(ABC-type dipeptide/oligopeptide/nickel transport systems, permease components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.142(Dipeptide transport system permease protein dppC,dipeptide transporter,ABC-type antimicrobial peptide transport system, permease component,nickel ABC transporter, permease subunit NikC,Binding-protein-dependent transport system inner membrane component) b3542(dipeptide/heme transporter) BN373_45351(dipeptide ABC transporter, permease protein DppC) t3887(dipeptide transport system permease protein DppC) SL1344_3594(dipeptide transport system permease protein DppC) Cluster426 1 1 1 1 1 1 1 ROD_42661(dipeptide ABC transporter, ATP-binding protein) ENC_01490(oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.143(Glutathione import ATP-binding protein GsiA,dipeptide transporter ATP-binding subunit,ABC-type oligopeptide transport system, ATPase component,nickel import ATP-binding protein NikD,Oligopeptide/dipeptide transporter, C-terminal region) b3541(dipeptide/heme transporter) BN373_45341(dipeptide ABC transporter, ATP-binding protein DppD) t3888(dipeptide transport ATP-binding protein DppD) SL1344_3593(dipeptide transport ATP-binding protein DppD) Cluster427 1 1 1 1 1 1 1 ROD_42691(putative membrane protein) ENC_27360(cellulose synthase operon protein YhjU) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.152(cellulose synthase operon protein YhjU,Protein of unknown function (DUF3260)) b3538(inner membrane protein, predicted endoglucanase, DUF3260 family) BN373_45251(cellulose biosynthesis protein BcsG) t3893(putative membrane protein) SL1344_3589(putative membrane protein) Cluster428 1 1 1 1 1 1 1 ROD_42701(putative membrane protein) ENC_27350(celllulose biosynthesis operon protein BcsF/YhjT) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.153(celllulose biosynthesis operon protein BcsF/YhjT,Protein of unknown function (DUF2636)) b3537(predicted protein) BN373_45241(cellulose biosynthesis protein BcsF) t3894(putative membrane protein) SL1344_3588(putative membrane protein) Cluster429 1 1 1 1 1 1 1 ROD_42711(conserved hypothetical protein) ENC_27340(cellulose biosynthesis protein BcsE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.154(cellulose biosynthesis protein BcsE,cellulose biosynthesis protein BcsE,Protein of unknown function (DUF2819)) b3536(cellulose production protein) BN373_45231(cellulose biosynthesis protein BcsE) t3895(conserved hypothetical protein) SL1344_3587(conserved hypothetical protein) Cluster430 1 1 1 1 1 1 1 ROD_42721(conserved hypothetical protein) ENC_27330(Protein of unknown function (DUF2629).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.155(Protein of unknown function (DUF2629)) b3535(putative protein) BN373_45221(conserved hypothetical protein) t3896(conserved hypothetical protein) SL1344_3586(conserved hypothetical protein) Cluster431 1 1 1 1 1 1 1 ROD_42751(cyclic di-GMP-binding protein (cellulose synthase regulator subunit B)) ENC_27300(Bacterial cellulose synthase subunit.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.158(Cellulose synthase regulatory subunit,cellulose synthase regulator protein,Bacterial cellulose synthase subunit) b3532(regulator of cellulose synthase, cyclic di-GMP binding) BN373_45191(cyclic di-GMP binding protein) t3899(putative polysaccharide biosynthesis protein subunit B) SL1344_3583(putative polysaccharide biosynthesis protein subunit B) Cluster432 1 1 1 1 1 1 1 ROD_42761(endo-1,4-beta-glucanase (cellulase)) ENC_27290(Cellulase family 8) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.159(Endoglucanase precursor,endo-1,4-D-glucanase,Glycosyl hydrolases family 8) b3531(endo-1,4-D-glucanase) BN373_45181(cellulase) t3900(probable endoglucanase precursor) SL1344_3582(probable endoglucanase precursor) Cluster433 1 1 1 1 1 1 1 ROD_42781(putative signal transduction protein) ENC_27260(diguanylate cyclase/phosphodiesterase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.161(hypothetical protein,putative diguanylate cyclase,MHYT domain (predicted integral membrane sensor domain),EAL domain) b3529(predicted diguanylate cyclase) BN373_45161(putative diguanylate cyclase) t3902(conserved hypothetical protein) SL1344_3580(conserved hypothetical protein) Cluster434 1 1 1 1 1 1 1 ROD_42791(C4-dicarboxylate transport protein) ENC_27250(Na+/H+-dicarboxylate symporters) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.162(Aerobic C4-dicarboxylate transport protein,C4-dicarboxylate transporter DctA,Sodium:dicarboxylate symporter family) b3528(C4-dicarboxylic acid, orotate and citrate transporter) BN373_45151(aerobic C4-dicarboxylate transport protein) t3903(C4-dicarboxylate transport protein) SL1344_3579(C4-dicarboxylate transport protein) Cluster435 1 1 1 1 1 1 1 ROD_42801(putative protease) ENC_27240(Predicted Zn-dependent peptidases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.163(hypothetical protein,Peptidase M16 inactive domain) b3527(predicted zinc-dependent peptidase) BN373_45141(peptidase, M16 (pitrilysin) family) t3904(putative zinc-protease precursor) SL1344_3578(putative zinc-protease precursor) Cluster436 1 1 1 1 1 1 1 ROD_42811(2-dehydro-3-deoxygluconokinase) ENC_27230(2-keto-3-deoxygluconate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.164(5-dehydro-2-deoxygluconokinase,aminoimidazole riboside kinase,Uncharacterized protein conserved in bacteria,ribokinase,pfkB family carbohydrate kinase) b3526(ketodeoxygluconokinase) BN373_45131(2-dehydro-3-deoxygluconokinase) t3905(2-dehydro-3-deoxygluconokinase) SL1344_3577(2-dehydro-3-deoxygluconokinase) Cluster437 1 1 1 1 1 1 1 ROD_42831(putative outer membrane assembly protein) ENC_27210(Uncharacterized protein involved in outer membrane biogenesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.166(putative assembly protein,Uncharacterized protein involved in outer membrane biogenesis,AsmA family) b3524(Inner membrane protein, AsmA family) BN373_45111(AsmA family protein) t3907(putative membrane protein) SL1344_3575(putative membrane protein) Cluster438 1 1 1 1 1 1 1 ROD_42841(major facilitator superfamily protein) ENC_27200(metabolite-proton symporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.167(Inner membrane metabolite transport protein yhjE,shikimate transporter,Transposase and inactivated derivatives,MFS transporter, metabolite:H+ symporter (MHS) family protein,Sugar (and other) transporter) b3523(inner membrane protein, predicted transporter) BN373_45101(MFS transporter, metabolite:H+ symporter (MHS) family protein) t3908(hypothetical metabolite transport protein) SL1344_3574(hypothetical metabolite transport protein) Cluster439 1 1 1 1 1 1 1 ROD_42851(putative membrane protein) ENC_27190(ribonuclease, putative) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.168(Inner membrane protein yhjD,inner membrane protein YhjD,Ribonuclease BN-like family) b3522(putative alternate lipid exporter, suppressor of msbA and KDO essentiality, inner membrane protein) BN373_45091(putative ribonuclease) t3909(putative membrane protein) SL1344_3573(putative membrane protein) Cluster440 1 1 1 1 1 1 1 ROD_42861(LysR-family transcriptional regulator) ENC_27180(transcriptional regulator, LysR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.169(D-malate degradation protein R,DNA-binding transcriptional activator GcvA,ABC-type uncharacterized transport system, periplasmic component,putative choline sulfate-utilization transcription factor,LysR substrate binding domain) b3521(predicted DNA-binding transcriptional regulator) BN373_45081(transcriptional regulator, LysR family) t3910(hypothetical lysR-family transcriptional regulator) SL1344_3572(hypothetical lysR-family transcriptional regulator) Cluster441 1 1 1 1 1 1 1 ROD_42921(cytoplasmic trehalase) ENC_27110(Neutral trehalase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.171(Cytoplasmic trehalase,trehalase,Trehalase) b3519(cytoplasmic trehalase) BN373_45051(putative trehalase) t3914(cytoplasmic trehalase) SL1344_3568(cytoplasmic trehalase) Cluster442 1 1 1 1 1 1 1 ROD_42991(glutathione reductase) ENC_27080(NADPH-glutathione reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.199(Glutathione reductase,glutathione reductase,Uncharacterized conserved protein,glutathione-disulfide reductase,Pyridine nucleotide-disulphide oxidoreductase) b3500(glutathione oxidoreductase) BN373_45021(glutathione-disulfide reductase) t3918(glutathione reductase) SL1344_3562(glutathione reductase) Cluster443 1 1 1 1 1 1 1 ROD_43001(conserved hypothetical protein) ENC_27070(Protein involved in catabolism of external DNA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.200(hypothetical protein,Protein involved in catabolism of external DNA,Protein of unknown function (DUF519)) b3499(protein required for the utilization of DNA as a carbon source, predicted DNA processing protein) BN373_45011(DNA utilization protein YhiR) t3919(conserved hypothetical protein) SL1344_3561(conserved hypothetical protein) Cluster444 1 1 1 1 1 1 1 ROD_43011(oligopeptidase A) ENC_27050(oligopeptidase A . Metallo peptidase. MEROPS family M03A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.201(Oligopeptidase A,oligopeptidase A,Zn-dependent oligopeptidases,oligoendopeptidase, M3 family,Peptidase family M3) b3498(oligopeptidase A) BN373_44991(oligopeptidase A) t3922(oligopeptidase A) SL1344_3559(oligopeptidase A) Cluster445 1 1 1 1 1 1 1 ROD_43041(universal stress protein A) ENC_27030(Universal stress protein UspA and related nucleotide-binding proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.204(Universal stress protein A,universal stress global response regulator UspA,Universal stress protein family) b3495(universal stress global response regulator) BN373_44961(universal stress protein A) t3925(universal stress protein A) SL1344_3556(universal stress protein A) Cluster446 1 1 1 1 1 1 1 ROD_43051(universal stress protein B) ENC_27020(Universal stress protein B (UspB).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.205(Universal stress protein B,universal stress protein UspB,Universal stress protein B (UspB)) b3494(universal stress (ethanol tolerance) protein B) BN373_44951(universal stress protein B) t3926(universal stress protein B) SL1344_3555(universal stress protein B) Cluster447 1 1 1 1 1 1 1 ROD_43451(putative lipoprotein) ENC_26670(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.229(hypothetical protein,hypothetical protein) b3472(periplasmic protein, predicted lipoprotein) BN373_44731(putative lipoprotein) t3942(putative lipoprotein) SL1344_3545(putative lipoprotein) Cluster448 1 1 1 1 1 1 1 ROD_43461(putative membrane protein) ENC_26660(conserved hypothetical integral membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.230(Inner membrane protein yhhQ,hypothetical protein,conserved hypothetical integral membrane protein,Uncharacterized ACR, YhhQ family COG1738) b3471(inner membrane protein, DUF165 family) BN373_44721(putative membrane protein) t3943(putative membrane protein) SL1344_3544(putative membrane protein) Cluster449 1 1 1 1 1 1 1 ROD_43471(sulfurtransferase (tRNA 2-thiouridine synthesizin protein A)) ENC_26650(Predicted redox protein, regulator of disulfide bond formation) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.231(Sulfurtransferase TusA,sulfur transfer protein SirA,Uncharacterized conserved protein,selenium metabolism protein YedF,SirA-like protein) b3470(sulfurtransferase required 2-thiolation step of mnm(5)-s(2)U34-tRNA synthesis) BN373_44711(sulfurtransferase TusA) t3944(conserved hypothetical protein) SL1344_3543(conserved hypothetical protein) Cluster450 1 1 1 1 1 1 1 ROD_43521(lead, cadmium, zinc and mercury-transporting ATPase) ENC_26610(heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.232(Lead, cadmium, zinc and mercury-transporting ATPase,zinc/cadmium/mercury/lead-transporting ATPase,Uncharacterized protein conserved in bacteria,heavy metal translocating P-type ATPase,E1-E2 ATPase) b3469(zinc, cobalt and lead efflux system) BN373_44701(lead, cadmium, zinc and mercury-transporting ATPase) t3946(heavy metal-transporting ATPase) SL1344_3541(heavy metal-transporting ATPase) Cluster451 1 1 1 1 1 1 1 ROD_43531(putative membrane protein) ENC_26600(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.233(YhhN-like protein) b3468(predicted inner membrane protein, TMEM86 family) BN373_44691(putative membrane protein) t3947(putative membrane protein) SL1344_3540(putative membrane protein) Cluster452 1 1 1 1 1 1 1 ROD_43541(putative exported protein) ENC_26590(Protein of unknown function (DUF2500).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.234(Protein of unknown function (DUF2500)) b3467(conserved protein, DUF2500 family) BN373_44681(conserved hypothetical protein) t3948(putative membrane protein) SL1344_3539(putative inner membrane protein) Cluster453 1 1 1 1 1 1 1 ROD_43551(putative membrane protein) ENC_26580(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.235(hypothetical protein,Predicted membrane protein,Protein of unknown function (DUF1145)) b3466(conserved protein, DUF1145 family) BN373_44671(conserved hypothetical protein) t3949(putative membrane protein) SL1344_3538(putative membrane protein) Cluster454 1 1 1 1 1 1 1 ROD_43561(conserved hypothetical protein) ENC_26570(16S rRNA m(2)G-966 methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.236(Ribosomal RNA small subunit methyltransferase D,16S rRNA m(2)G966-methyltransferase,Predicted O-methyltransferase,RNA methyltransferase, RsmD family,Conserved hypothetical protein 95) b3465(16S rRNA m(2)G966 methyltransferase, SAM-dependent) BN373_44661(putative methyltransferase) t3950(conserved hypothetical protein) SL1344_3537(conserved hypothetical protein) Cluster455 1 1 1 1 1 1 1 ROD_43571(cell division protein) ENC_26560(signal recognition particle-docking protein FtsY) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.237(Cell division protein FtsY,signal recognition particle-docking protein FtsY,Signal recognition particle GTPase,signal recognition particle-docking protein FtsY,SRP54-type protein, GTPase domain) b3464(Signal Recognition Particle (SRP) receptor) BN373_44651(cell division protein FtsY) t3951(cell division protein) SL1344_3536(cell division protein) Cluster456 1 1 1 1 1 1 1 ROD_43581(cell division ATP-binding protein) ENC_26550(cell division ATP-binding protein FtsE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.238(Cell division ATP-binding protein FtsE,cell division protein FtsE,ABC-type spermidine/putrescine transport systems, ATPase components,cell division ATP-binding protein FtsE,ABC transporter) b3463(predicted transporter subunit: ATP-binding component of ABC superfamily) BN373_44641(cell division ATP-binding protein FtsE) t3952(cell division ATP-binding protein FtsE) SL1344_3535(cell division ATP-binding protein FtsE) Cluster457 1 1 1 1 1 1 1 ROD_43591(cell division protein) ENC_26540(cell division protein FtsX) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.239(Cell division protein FtsX,cell division ABC transporter subunit FtsX,putative protein insertion permease FtsX,FtsX-like permease family) b3462(predicted transporter subunit: membrane component of ABC superfamily) BN373_44631(cell division protein FtsX) t3953(cell division protein) SL1344_3534(cell division protein) Cluster458 1 1 1 1 1 1 1 ROD_43611(RNA polymerase sigma-32 factor) ENC_26530(RNA polymerase, sigma 32 subunit, RpoH) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.240(Heat shock regulatory protein F33.4,RNA polymerase factor sigma-32,alternative sigma factor RpoH,Sigma-70 region 2) b3461(RNA polymerase, sigma 32 (sigma H) factor) BN373_44621(alternative sigma factor RpoH) t3954(RNA polymerase sigma-32 factor) SL1344_3533(RNA polymerase sigma-32 factor) Cluster459 1 1 1 1 1 1 1 ROD_43661(putative acetyltransferase) ENC_26500(Acetyltransferase, GNAT family.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.244(hypothetical protein,Acetyltransferase, GNAT family) b3459(pantothenate synthesis protein, predicted acetyltransferase) BN373_44571(acetyltransferase, GNAT family) t3957(conserved hypothetical protein) SL1344_3531(conserved hypothetical protein) Cluster460 1 1 1 1 1 1 1 ROD_43691(high-affinity branched-chain amino acid ABC transporter, permease protein) ENC_26470(L-leucine ABC transporter membrane protein/L-isoleucine ABC transporter membrane protein/L-valine ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.246(LIV-I protein H,branched-chain amino acid transporter permease subunit LivH,Branched-chain amino acid ABC-type transport system, permease components,urea ABC transporter, permease protein UrtB,Branched-chain amino acid transport system / permease component) b3457(leucine/isoleucine/valine transporter subunit) BN373_44541(high-affinity branched-chain amino acid ABC transporter, permease protein LivH) t3959(high-affinity branched-chain amino acid transport system permease protein) SL1344_3529(high-affinity branched-chain amino acid transport system permease protein) Cluster461 1 1 1 1 1 1 1 ROD_43701(high-affinity branched-chain amino acid ABC transporter, permease protein) ENC_26460(L-leucine ABC transporter membrane protein/L-isoleucine ABC transporter membrane protein/L-valine ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.247(leucine/isoleucine/valine transporter permease subunit,ABC-type branched-chain amino acid transport system, permease component,urea ABC transporter, permease protein UrtC,Branched-chain amino acid transport system / permease component) b3456(leucine/isoleucine/valine transporter subunit) BN373_44531(high-affinity branched-chain amino acid ABC transporter, permease protein LivM) t3960(high-affinity branched-chain amino acid transport system permease protein) SL1344_3528(high-affinity branched-chain amino acid transport system permease protein) Cluster462 1 1 1 1 1 1 1 ROD_43711(high-affinity branched-chain amino acid ABC transporter, ATP-binding protein) ENC_26450(L-leucine ABC transporter ATP-binding protein/L-isoleucine ABC transporter ATP-binding protein/L-valine ABC transporter ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.248(Lipopolysaccharide export system ATP-binding protein LptB,leucine/isoleucine/valine transporter ATP-binding subunit,Uncharacterized ABC-type transport system, ATPase component,urea ABC transporter, ATP-binding protein UrtD,ABC transporter) b3455(leucine/isoleucine/valine transporter subunit) BN373_44521(high-affinity branched-chain amino acid ABC transporter, ATP-binding protein LivG) t3961(high-affinity branched-chain amino acid transport ATP-binding protein) SL1344_3527(high-affinity branched-chain amino acid transport ATP-binding protein) Cluster463 1 1 1 1 1 1 1 ROD_43721(high-affinity branched-chain amino acid ABC transporter, ATP-binding protein) ENC_26440(L-leucine ABC transporter ATP-binding protein/L-isoleucine ABC transporter ATP-binding protein/L-valine ABC transporter ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.249(LIV-I protein F,leucine/isoleucine/valine transporter ATP-binding subunit,ABC-type Na+ transport system, ATPase component,urea ABC transporter, ATP-binding protein UrtE,ABC transporter) b3454(leucine/isoleucine/valine transporter subunit) BN373_44511(high-affinity branched-chain amino acid ABC transporter, ATP-binding protein LivF) t3962(high-affinity branched-chain amino acid transport ATP-binding protein) SL1344_3526(high-affinity branched-chain amino acid transport ATP-binding protein) Cluster464 1 1 1 1 1 1 1 ROD_43761(glycerol-3-phosphate ABC transporter, permease protein) ENC_26420(glycerol 3-phosphate ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.251(sn-glycerol-3-phosphate transport system permease protein ugpA,glycerol-3-phosphate transporter permease,ABC-type polysaccharide transport system, permease component,putative 2-aminoethylphosphonate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component) b3452(glycerol-3-phosphate transporter subunit) BN373_44491(glycerol-3-phosphate ABC transporter, permease protein UgpA) t3965(glycerol-3-phosphate transport system permease protein) SL1344_3522(glycerol-3-phosphate transport system permease protein) Cluster465 1 1 1 1 1 1 1 ROD_43771(sn-Glycerol-3-phosphate ABC transporter, permease protein) ENC_26410(glycerol 3-phosphate ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.252(Inner membrane ABC transporter permease protein ycjP,glycerol-3-phosphate transporter membrane protein,ABC-type maltose transport systems, permease component,Binding-protein-dependent transport system inner membrane component) b3451(glycerol-3-phosphate transporter subunit) BN373_44481(glycerol-3-phosphate ABC transporter, permease protein UgpE) t3966(sn-Glycerol-3-phosphate transport system permease protein) SL1344_3521(sn-Glycerol-3-phosphate transport system permease protein) Cluster466 1 1 1 1 1 1 1 ROD_43781(sn-Glycerol-3-phosphate ABC transporter, ATP-binding protein) ENC_26400(glycerol 3-phosphate ABC transporter ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.253(sn-glycerol-3-phosphate import ATP-binding protein UgpC,glycerol-3-phosphate transporter ATP-binding subunit,ABC-type spermidine/putrescine transport systems, ATPase components,putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein,ABC transporter) b3450(glycerol-3-phosphate transporter subunit) BN373_44471(glycerol-3-phosphate ABC transporter, ATP-binding protein UgpC) t3967(sn-Glycerol-3-phosphate transport ATP-binding protein) SL1344_3520(sn-Glycerol-3-phosphate transport ATP-binding protein) Cluster467 1 1 1 1 1 1 1 ROD_43791(glycerophosphoryl diester phosphodiesterase) ENC_26390(Glycerophosphoryl diester phosphodiesterase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.254(Glycerophosphoryl diester phosphodiesterase,cytoplasmic glycerophosphodiester phosphodiesterase,Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase,Glycerophosphoryl diester phosphodiesterase family) b3449(glycerophosphodiester phosphodiesterase, cytosolic) BN373_44461(glycerophosphoryl diester phosphodiesterase) t3968(glycerophosphoryl diester phosphodiesterase) SL1344_3519(glycerophosphoryl diester phosphodiesterase) Cluster468 1 1 1 1 1 1 1 ROD_43811(gamma-glutamyltranspeptidase) ENC_26370(gamma-glutamyltransferase 1 . Threonine peptidase. MEROPS family T03) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.256(Gamma-glutamyltranspeptidase precursor,gamma-glutamyltranspeptidase,gamma-glutamyltransf erase,Gamma-glutamyltranspeptidase) b3447(gamma-glutamyltranspeptidase) BN373_44451(gamma-glutamyltransferase) t3970(gamma-glutamyltranspeptidase precursor) SL1344_3517(gamma-glutamyltranspeptidase precursor) Cluster469 1 1 1 1 1 1 1 ROD_43841(putative acetyltransferase) ENC_26360(Acetyltransferases, including N-acetylases of ribosomal proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.257(putative acetyltransferase YhhY,Predicted acetyltransferase,pseudaminic acid biosynthesis N-acetyl transferase,Acetyltransferase (GNAT) family) b3441(predicted acetyltransferase) BN373_44441(acetyltransferase, GNAT family) t3975(putative acetyltransferase) SL1344_3512(putative acetyltransferase) Cluster470 1 1 1 1 1 1 1 ROD_43861(putative oxidoreductase) ENC_26350(Predicted dehydrogenases and related proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.259(Uncharacterized oxidoreductase yhhX,putative oxidoreductase,Uncharacterized protein conserved in bacteria,Oxidoreductase family, NAD-binding Rossmann fold) b3440(predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain) BN373_44421(oxidoreductase, NAD-binding) t3976(putative oxidoreductase) SL1344_3511(putative oxidoreductase) Cluster471 1 1 1 1 1 1 1 ROD_43871(conserved hypothetical protein) ENC_26340(Pirin-related protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.260(Quercetin 2,3-dioxygenase,Pirin) b3439(quercetinase activity in vitro) BN373_44411(pirin family protein) t3977(conserved hypothetical protein) SL1344_3510(conserved hypothetical protein) Cluster472 1 1 1 1 1 1 1 ROD_43881(gluconate utilization operon repressor) ENC_26330(transcriptional regulator, LacI family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.261(Gluconate utilization system GNT-I transcriptional repressor,gluconate operon transcriptional regulator,ABC-type sugar transport system, periplasmic component,catabolite control protein A,Periplasmic binding proteins and sugar binding domain of LacI family) b3438(DNA-binding transcriptional repressor) BN373_44401(transcriptional regulator GntR) t3978(gluconate utilization operon repressor) SL1344_3509(gluconate utilization operon repressor) Cluster473 1 1 1 1 1 1 1 ROD_43891(thermoresistant gluconokinase) ENC_26320(gluconate kinase, SKI family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.262(Thermoresistant gluconokinase,gluconate kinase 1,Gluconate kinase,carbohydrate kinase, thermoresistant glucokinase family,Shikimate kinase) b3437(gluconate kinase 2) BN373_44391(thermoresistant gluconokinase) t3980(putative gluconokinase) SL1344_3508(putative gluconokinase) Cluster474 1 1 1 1 1 1 1 ROD_43921(aspartate-semialdehyde dehydrogenase) ENC_26270(aspartate semialdehyde dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.267(Aspartate-semialdehyde dehydrogenase,aspartate-semialdehyde dehydrogenase,Aspartate-semialdehyde dehydrogenase,aspartate-semialdehyde dehydrogenase,Semialdehyde dehydrogenase, dimerisation domain) b3433(aspartate-semialdehyde dehydrogenase, NAD(P)-binding) BN373_44371(aspartate-semialdehyde dehydrogenase) t3981(aspartate-semialdehyde dehydrogenase) SL1344_3506(aspartate-semialdehyde dehydrogenase) Cluster475 1 1 1 1 1 1 1 ROD_43931(1,4-alpha-glucan branching enzyme) ENC_26260(alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.268(1,4-alpha-glucan branching enzyme GlgB,glycogen branching enzyme,Maltooligosyl trehalose synthase,1,4-alpha-glucan branching enzyme,Carbohydrate-binding module 48 (Isoamylase N-terminal domain)) b3432(1,4-alpha-glucan branching enzyme) BN373_44361(1,4-alpha-glucan branching enzyme) t3982(1,4-alpha-glucan branching enzyme) SL1344_3505(1,4-alpha-glucan branching enzyme) Cluster476 1 1 1 1 1 1 1 ROD_43951(glucose-1-phosphate adenylyltransferase) ENC_26240(glucose-1-phosphate adenylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.270(Glucose-1-phosphate adenylyltransferase,glucose-1-phosphate adenylyltransferase,glucose-1-phosphate adenylyltransferase,Nucleotidyl transferase) b3430(glucose-1-phosphate adenylyltransferase) BN373_44341(glucose-1-phosphate adenylyltransferase) t3984(glucose-1-phosphate adenylyltransferase) SL1344_3503(glucose-1-phosphate adenylyltransferase) Cluster477 1 1 1 1 1 1 1 ROD_43961(glycogen synthase) ENC_26230(glycogen synthase (ADP-glucose)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.271(Glycogen synthase,glycogen synthase,Glycogen synthase,glycogen/starch synthase, ADP-glucose type,Starch synthase catalytic domain) b3429(glycogen synthase) BN373_44331(starch synthase) t3985(glycogen synthase) SL1344_3502(glycogen synthase) Cluster478 1 1 1 1 1 1 1 ROD_43981(aerobic glycerol-3-phosphate dehydrogenase) ENC_26210(homodimeric glycerol 3-phosphate dehydrogenase (quinone)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.276(Aerobic glycerol-3-phosphate dehydrogenase,glycerol-3-phosphate dehydrogenase,Anaerobic glycerol-3-phosphate dehydrogenase,glycerol-3-phosphate dehydrogenase, anaerobic, A subunit,FAD dependent oxidoreductase) b3426(sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding) BN373_44311(glycerol-3-phosphate dehydrogenase) t3987(aerobic glycerol-3-phosphate dehydrogenase) SL1344_3493(aerobic glycerol-3-phosphate dehydrogenase) Cluster479 1 1 1 1 1 1 1 ROD_43991(thiosulfate sulfurtransferase) ENC_26200(Rhodanese-related sulfurtransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.277(Thiosulfate sulfurtransferase glpE,thiosulfate sulfurtransferase,Uncharacterized conserved protein,Rhodanese-like domain) b3425(thiosulfate:cyanide sulfurtransferase (rhodanese)) BN373_44301(thiosulfate sulfurtransferase glpE) t3988(conserved hypothetical protein) SL1344_3492(conserved hypothetical protein) Cluster480 1 1 1 1 1 1 1 ROD_44001(putative membrane protein) ENC_26190(Uncharacterized membrane protein (homolog of Drosophila rhomboid)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.278(Rhomboid protease glpG,intramembrane serine protease GlpG,rhomboid family protease GlpG,Protein of unknown function (DUF3582)) b3424(rhomboid intramembrane serine protease) BN373_44291(peptidase, S54 (rhomboid) family) t3989(putative membrane protein) SL1344_3491(putative membrane protein) Cluster481 1 1 1 1 1 1 1 ROD_44011(glycerol-3-phosphate regulon repressor) ENC_26180(Transcriptional regulators of sugar metabolism) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.279(Glycerol-3-phosphate regulon repressor,DNA-binding transcriptional repressor GlpR,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,Bacterial regulatory proteins, deoR family) b3423(DNA-binding transcriptional repressor) BN373_44281(glycerol-3-phosphate regulon repressor) t3990(glycerol-3-phosphate regulon repressor) pseudoSL1344_3489(putative glycerol-3-phosphate regulon repressor (pseudogene)) Cluster482 1 1 1 1 1 1 1 ROD_44021(regulatory protein) ENC_26170(ATP-dependent transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.282(ATP-dependent transcriptional activator malT,transcriptional regulator MalT,ATP-dependent transcriptional regulator,transcriptional regulator EpsA,Bacterial regulatory proteins, luxR family) b3418(DNA-binding transcriptional activator for the mal regulon and maltotriose-ATP-binding protein) BN373_44271(transcriptional regulator MalT) t3991(MalT regulatory protein) SL1344_3482(MalT regulatory protein) Cluster483 1 1 1 1 1 1 1 ROD_44071(4-alpha-glucanotransferase) ENC_26150(4-alpha-glucanotransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.284(4-alpha-glucanotransferase,4-alpha-glucanotransfe rase,4-alpha-glucanotransferase,4-alpha-glucanotransferase) b3416(4-alpha-glucanotransferase (amylomaltase)) BN373_44251(4-alpha-glucanotransferase) t3993(4-alpha-glucanotransferase) SL1344_3480(4-alpha-glucanotransferase) Cluster484 1 1 1 1 1 1 1 ROD_44081(high-affinity gluconate transporter) ENC_26140(gluconate permease GntT (TC 2.A.8.1.4)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.285(Gnt-I system,high-affinity gluconate transporter,H+/gluconate symporter and related permeases,transporter, gluconate:H+ symporter (GntP) family,GntP family permease) b3415(gluconate transporter, high-affinity GNT I system) BN373_44241(high-affinity gluconate transporter) t3994(high-affinity gluconate transporter) SL1344_3479(high-affinity gluconate transporter) Cluster485 1 1 1 1 1 1 1 ROD_44091(putative competence protein) ENC_26130(IscR-regulated protein YhgI) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.286(Fe/S biogenesis protein nfuA,Fe/S biogenesis protein NfuA,IscR-regulated protein YhgI,Iron-sulphur cluster biosynthesis) b3414(Fe/S biogenesis protein; possible scaffold/chaperone for damaged Fe/S proteins) BN373_44231(IscR-regulated protein YhgI) t3995(conserved hypothetical protein) SL1344_3478(conserved hypothetical protein) Cluster486 1 1 1 1 1 1 1 ROD_44101(putative competence protein) ENC_26120(Predicted amidophosphoribosyltransferases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.287(DNA utilization protein GntX,comF family protein,Phosphoribosyl transferase domain) b3413(protein required for the utilization of DNA as a carbon source) BN373_44221(protein GntX) t3996(putative competence protein) SL1344_3477(putative competence protein) Cluster487 1 1 1 1 1 1 1 ROD_44111(carboxylesterase (biotin synthesis protein BioH)) ENC_26110(carboxylesterase BioH (pimeloyl-CoA synthesis)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.288(Pimelyl-[acyl-carrier protein] methyl ester esterase,carboxylesterase BioH,pimelyl-[acyl-carrier protein] methyl ester esterase,Alpha/beta hydrolase family) b3412(pimeloyl-ACP carboxylesterase) BN373_44211(putative pimeloyl-BioC--CoA transferase BioH) t3997(putative biotin biosynthesis protein) SL1344_3476(putative biotin biosynthesis protein) Cluster488 1 1 1 1 1 1 1 ROD_44131(conserved hypothetical protein) ENC_26100(FeoC like transcriptional regulator.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.290(Ferrous iron transport protein C,ferrous iron transport protein FeoC,FeoC like transcriptional regulator) b3410(predicted DNA-binding transcriptional regulator) BN373_44191(conserved hypothetical protein) t3999(conserved hypothetical protein) SL1344_3474(conserved hypothetical protein) Cluster489 1 1 1 1 1 1 1 ROD_44141(ferrous iron transport protein B) ENC_26090(ferrous iron transporter FeoB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.291(Ferrous iron transport protein B,ferrous iron transport protein B,Fe2+ transport system protein B,ferrous iron transport protein B,Ferrous iron transport protein B) b3409(fused ferrous iron transporter, protein B: GTP-binding protein/membrane protein) BN373_44181(ferrous iron transport protein B) t4000(ferrous iron transport protein B) SL1344_3473(ferrous iron transport protein B) Cluster490 1 1 1 1 1 1 1 ROD_44151(ferrous iron transport protein A) ENC_26080(Fe2+ transport system protein A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.292(Ferrous iron transport protein A,ferrous iron transport protein A,FeoA domain) b3408(ferrous iron transporter, protein A) BN373_44171(ferrous iron transport protein A) t4001(putative ferrous iron transport protein) SL1344_3472(putative ferrous iron transport protein) Cluster491 1 1 1 1 1 1 1 ROD_44171(putative transcription accessory protein) ENC_26070(Transcriptional accessory protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.293(hypothetical protein,30S ribosomal protein S1,ribosomal protein S1,Tex-like protein N-terminal domain) b3407(predicted transcriptional accessory protein) BN373_44151(S1 RNA binding domain protein) t4002(putative transcription accessory protein) SL1344_3471(putative transcription accessory protein) Cluster492 1 1 1 1 1 1 1 ROD_44191(two-component response regulator) ENC_26050(Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.295(Transcriptional regulatory protein OmpR,osmolarity response regulator,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain) b3405(DNA-binding response regulator in two-component regulatory system with EnvZ) BN373_44131(transcriptional regulatory protein OmpR) t4004(two-component response regulator OmpR) SL1344_3469(two-component response regulator OmpR) Cluster493 1 1 1 1 1 1 1 ROD_44221(heat shock protein) ENC_26020(Disulfide bond chaperones of the HSP33 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.300(Heat shock protein 33,Hsp33-like chaperonin,Phosphoenolpyruvate carboxykinase (ATP),Hsp33 protein) b3401(heat shock protein Hsp33) BN373_44101(chaperonin HslO) t4008(heat shock protein) SL1344_3465(heat shock protein) Cluster494 1 1 1 1 1 1 1 ROD_44231(heat shock protein) ENC_26010(heat shock protein Hsp15) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.301(Heat shock protein 15,ribosome-associated heat shock protein Hsp15,S4 domain) b3400(ribosome-associated heat shock protein Hsp15) BN373_44091(heat shock protein 15) t4009(heat shock protein) SL1344_3464(heat shock protein) Cluster495 1 1 1 1 1 1 1 ROD_44241(putative hydrolase) ENC_26000(haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.302((S)-2-haloacid dehalogenase,GMP/IMP nucleotidase,HAD hydrolase, family IA, variant 3,haloacid dehalogenase-like hydrolase) b3399(GMP/IMP nucleotidase) BN373_44081(HAD hydrolase, family IA) t4010(putative hydrolase) SL1344_3463(putative hydrolase) Cluster496 1 1 1 1 1 1 1 ROD_44261(ADP compounds hydrolase) ENC_25960(NUDIX domain.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.304(ADP compounds hydrolase nudE,adenosine nucleotide hydrolase NudE,NUDIX domain) b3397(adenosine nucleotide hydrolase; substrates include Ap3A, Ap2A, ADP-ribose, NADH) BN373_44061(ADP compounds hydrolase NudE) t4012(putative NUDIX hydrolase) SL1344_3461(putative NUDIX hydrolase) Cluster497 1 1 1 1 1 1 1 ROD_44281(putative fimbrial protein HofM) ENC_25930(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.306(hypothetical protein) b3395(protein required for the utilization of DNA as a carbon source, pilus assembly protein homolog) BN373_44041(putative pilus assembly protein) t4014(conserved hypothetical protein) SL1344_3459(conserved hypothetical protein) Cluster498 1 1 1 1 1 1 1 ROD_44291(putative fimbrial protein HofN) ENC_25920(Tfp pilus assembly protein PilN) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.307(Fimbrial assembly protein (PilN)) b3394(protein required for the utilization of DNA as a carbon source; fimbrial assembly protein homolog) BN373_44031(hypothetical protein) t4016(putative membrane protein) SL1344_3458(putative membrane protein) Cluster499 1 1 1 1 1 1 1 ROD_44311(putative fimbrial protein HofP) ENC_25900(Protein of unknown function (DUF2531).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.309(Protein of unknown function (DUF2531)) b3392(protein required for the utilization of DNA as a carbon source) BN373_44011(conserved hypothetical protein) t4017(conserved hypothetical protein) SL1344_3456(conserved hypothetical protein) Cluster500 1 1 1 1 1 1 1 ROD_44331(shikimate kinase I) ENC_25870(shikimate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.311(Shikimate kinase 1,shikimate kinase I,Gluconate kinase,Shikimate kinase) b3390(shikimate kinase I) BN373_43981(shikimate kinase) t4019(shikimate kinase I) SL1344_3454(shikimate kinase I) Cluster501 1 1 1 1 1 1 1 ROD_44351(DamX protein) ENC_25850(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.313(hypothetical protein,cell division protein DamX,Uncharacterized protein conserved in bacteria,Sporulation related domain) b3388(cell division protein that binds to the septal ring) BN373_43961(DamX protein) t4021(DamX protein) SL1344_3452(DamX protein) Cluster502 1 1 1 1 1 1 1 ROD_44361(DNA adenine methylase) ENC_25840(DNA adenine methylase Dam) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.314(DNA adenine methylase,DNA adenine methylase,Site-specific DNA methylase,DNA adenine methylase,D12 class N6 adenine-specific DNA methyltransferase) b3387(DNA adenine methyltransferase) BN373_43951(DNA adenine methylase) t4022(DNA adenine methylase) SL1344_3451(DNA adenine methylase) Cluster503 1 1 1 1 1 1 1 ROD_44371(ribulose-phosphate 3-epimerase) ENC_25830(ribulose-phosphate 3-epimerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.315(Ribulose-phosphate 3-epimerase,ribulose-phosphate 3-epimerase,Pentose-5-phosphate-3-epimerase,ribulose-phosph ate 3-epimerase,Ribulose-phosphate 3 epimerase family) b3386(D-ribulose-5-phosphate 3-epimerase) BN373_43941(ribulose-phosphate 3-epimerase) t4023(ribulose-phosphate 3-epimerase) SL1344_3450(ribulose-phosphate 3-epimerase) Cluster504 1 1 1 1 1 1 1 ROD_44381(phosphoglycolate phosphatase) ENC_25820(phosphoglycolate phosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.316(Phosphoglycolate phosphatase,phosphoglycolate phosphatase,phosphoglycolate phosphatase, bacterial,haloacid dehalogenase-like hydrolase) b3385(phosphoglycolate phosphatase) BN373_43931(phosphoglycolate phosphatase) t4025(phosphoglycolate phosphatase) SL1344_3449(phosphoglycolate phosphatase) Cluster505 1 1 1 1 1 1 1 ROD_44391(tryptophanyl-tRNA synthetase) ENC_25810(tryptophanyl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.317(Tryptophan--tRNA ligase,tryptophanyl-tRNA synthetase,Tryptophanyl-tRNA synthetase,tryptophan--tRNA ligase,tRNA synthetases class I (W and Y)) b3384(tryptophanyl-tRNA synthetase) BN373_43921(tryptophanyl-tRNA synthetase) t4024(tryptophanyl-tRNA synthetase) SL1344_3448(tryptophanyl-tRNA synthetase) Cluster506 1 1 1 1 1 1 1 ROD_44431(nitrite reductase (NAD(P)H) small subunit) ENC_25790(assimilatory nitrite reductase (NAD(P)H) small subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.329(Nitrite reductase [NAD(P)H] small subunit,nitrite reductase small subunit,nitrite reductase [NAD(P)H], small subunit) b3366(nitrite reductase, NAD(P)H-binding, small subunit) BN373_43901(nitrite reductase [NAD(P)H], small subunit) t4030(nitrite reductase (NAD(P)H) small subunit) SL1344_3442(nitrite reductase (NAD(P)H) small subunit) Cluster507 1 1 1 1 1 1 1 ROD_46021(cytosine deaminase) ENC_34640(Cytosine deaminase and related metal-dependent hydrolases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3630(Cytosine deaminase,cytosine deaminase,Cytosine deaminase and related metal-dependent hydrolases,Amidohydrolase family) b0337(cytosine/isoguanine deaminase) BN373_43881(cytosine deaminase) t3251(cytosine deaminase) SL1344_3306(cytosine deaminase) Cluster508 1 1 1 1 1 1 1 ROD_44451(major facilitator superfamily protein) ENC_25760(Major Facilitator Superfamily.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.331(hypothetical protein,putative transporter,Major Facilitator Superfamily) b3364(predicted transporter) BN373_43871(major facilitator family transporter TsgA) t4032(putative membrane protein) SL1344_3440(putative membrane protein) Cluster509 1 1 1 1 1 1 1 ROD_44461(peptidyl-prolyl cis-trans isomerase) ENC_25750(Peptidyl-prolyl cis-trans isomerase (rotamase)-cyclophilin family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.332(Peptidyl-prolyl cis-trans isomerase A precursor,peptidyl-prolyl cis-trans isomerase A (rotamase A),Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD) b3363(peptidyl-prolyl cis-trans isomerase A (rotamase A)) BN373_43861(peptidyl-prolyl cis-trans isomerase A) t4033(peptidyl-prolyl cis-trans isomerase) SL1344_3439(peptidyl-prolyl cis-trans isomerase) Cluster510 1 1 1 1 1 1 1 ROD_44521(cyclic AMP receptor protein (catabolite gene activator)) ENC_25690(cAMP-binding proteins-catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.338(cAMP regulatory protein,DNA-binding transcriptional dual regulator Crp,Predicted signal-transduction protein containing cAMP-binding and CBS domains,global nitrogen regulator NtcA,Cyclic nucleotide-binding domain) b3357(DNA-binding transcriptional dual regulator) BN373_43801(catabolite gene activator) t4039(cyclic AMP receptor protein,catabolite gene activator) SL1344_3433(cyclic AMP receptor protein,catabolite gene activator) Cluster511 1 1 1 1 1 1 1 ROD_44531(conserved hypothetical protein) ENC_25680(Predicted redox protein, regulator of disulfide bond formation) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.339(hypothetical protein,hypothetical protein,OsmC-like protein) b3356(conserved protein, OsmC family) BN373_43791(OsmC family protein) t4040(conserved hypothetical protein) SL1344_3432(conserved hypothetical protein) Cluster512 1 1 1 1 1 1 1 ROD_44551(conserved hypothetical protein) ENC_25650(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.341(hypothetical protein,hypothetical protein,Uncharacterised protein family (UPF0270)) b3354(conserved protein) BN373_43771(conserved hypothetical protein) t4042(conserved hypothetical protein) SL1344_3430(conserved hypothetical protein) Cluster513 1 1 1 1 1 1 1 ROD_44661(ABC transporter, ATP-binding protein) ENC_25530(ATPase components of ABC transporters with duplicated ATPase domains) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.343(Uncharacterized ABC transporter ATP-binding protein YheS,putative ABC transporter ATP-binding protein,ATP-dependent transcriptional regulator,ATP-binding cassette protein, ChvD family,ABC transporter) b3352(fused predicted transporter subunits of ABC superfamily: ATP-binding components) BN373_43751(ABC transporter, ATP-binding protein) t4046(probable ABC transporter ATP-binding protein) SL1344_3426(probable ABC transporter ATP-binding protein) Cluster514 1 1 1 1 1 1 1 ROD_44671(glutathione-regulated potassium-efflux system ancillary protein) ENC_25520(Kef-type potassium/proton antiporter accessory protein, CPA2 family (TC 2.A.37.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.344(General stress protein 14,glutathione-regulated potassium-efflux system ancillary protein KefG,Putative NADPH-quinone reductase (modulator of drug activity B),Flavodoxin-like fold) b3351(potassium-efflux system ancillary protein for KefB, glutathione-regulated) BN373_43741(glutathione-regulated potassium-efflux system ancillary protein KefG) t4047(putative oxidoreductase) SL1344_3425(putative oxidoreductase) Cluster515 1 1 1 1 1 1 1 ROD_44691(conserved hypothetical protein) ENC_25490(conserved hypothetical metal-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.346(conserved hypothetical protein,Probable metal-binding protein (DUF2387)) b4551(predicted protein) BN373_43721(conserved hypothetical protein) t4049(conserved hypothetical protein) SL1344_3423(conserved hypothetical protein) Cluster516 1 1 1 1 1 1 1 ROD_44701(FKBP-type peptidyl-prolyl cis-trans isomerase) ENC_25480(FKBP-type peptidyl-prolyl cis-trans isomerases 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.347(FKBP-type peptidyl-prolyl cis-trans isomerase slyD,FKBP-type peptidyl-prolyl cis-trans isomerase,FKBP-type peptidyl-prolyl cis-trans isomerase) b3349(FKBP-type peptidyl prolyl cis-trans isomerase (rotamase)) BN373_43711(FKBP-type peptidyl-prolyl cis-trans isomerase SlyD) t4050(FKBP-type peptidyl-prolyl cis-trans isomerase) SL1344_3422(FKBP-type peptidyl-prolyl cis-trans isomerase) Cluster517 1 1 1 1 1 1 1 ROD_44711(protein SlyX) ENC_25470(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.348(hypothetical protein,phi X174 lysis protein,SlyX) b3348(protein required for phi X174 lysis) BN373_43701(slyX protein) t4051(conserved hypothetical protein) SL1344_3421(conserved hypothetical protein) Cluster518 1 1 1 1 1 1 1 ROD_44721(FKBP-type peptidyl-prolyl isomerase) ENC_25460(FKBP-type peptidyl-prolyl cis-trans isomerases 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.349(FKBP-type peptidyl-prolyl cis-trans isomerase fkpA precursor,FKBP-type peptidyl-prolyl cis-trans isomerase,ABC-type uncharacterized transport system, permease component,peptidyl-prolyl isomerase, gliding motility-associated,Domain amino terminal to FKBP-type peptidyl-prolyl isomerase) b3347(FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase)) BN373_43691(FKBP-type peptidyl-prolyl cis-trans isomerase FkpA) t4052(FKBP-type peptidyl-prolyl isomerase) SL1344_3420(FKBP-type peptidyl-prolyl isomerase) Cluster519 1 1 1 1 1 1 1 ROD_44731(putative DNA binding protein) ENC_25450(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.350(Uncharacterized protein conserved in bacteria,YheO-like PAS domain) b3346(conserved protein) BN373_43681(conserved hypothetical protein) t4053(conserved hypothetical protein) SL1344_3419(conserved hypothetical protein) Cluster520 1 1 1 1 1 1 1 ROD_44741(tRNA 2-thiouridine synthesizin protein D (sulfurtransferase)) ENC_25440(sulfur relay protein TusD/DsrE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.351(Sulfurtransferase TusD,sulfur transfer complex subunit TusD,Uncharacterized conserved protein involved in intracellular sulfur reduction,sulfur relay protein TusD/DsrE,DsrE/DsrF-like family) b3345(sulfurtransferase for 2-thiolation step of mnm(5)-s(2)U34-tRNA synthesis) BN373_43671(sulfurtransferase TusD) t4054(conserved hypothetical protein) SL1344_3418(conserved hypothetical protein) Cluster521 1 1 1 1 1 1 1 ROD_44751(tRNA 2-thiouridine synthesizing protein c) ENC_25430(sulfur relay protein TusC/DsrF) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.352(tRNA 2-thiouridine synthesizing protein C,sulfur relay protein TusC,Uncharacterized protein involved in the oxidation of intracellular sulfur,sulfur relay protein TusC/DsrF,DsrE/DsrF-like family) b3344(protein required for 2-thiolation step of mnm(5)-s(2)U34-tRNA synthesis) BN373_43661(sulfur relay protein TusC/DsrF) t4055(conserved hypothetical protein) SL1344_3417(conserved hypothetical protein) Cluster522 1 1 1 1 1 1 1 ROD_44761(tRNA 2-thiouridine synthesizing protein B) ENC_25420(sulfur relay protein TusB/DsrH) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.353(tRNA 2-thiouridine synthesizing protein B,sulfur transfer complex subunit TusB,Uncharacterized conserved protein involved in oxidation of intracellular sulfur,sulfur relay protein TusB/DsrH,DsrH like protein) b3343(protein required for 2-thiolation step of mnm(5)-s(2)U34-tRNA synthesis) BN373_43651(protein TusB) t4056(conserved hypothetical protein) SL1344_3416(conserved hypothetical protein) Cluster523 1 1 1 1 1 1 1 ROD_44771(30S ribosomal subunit protein S12) ENC_25410(ribosomal protein S12, bacterial/organelle) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.354(30S ribosomal protein S12,30S ribosomal protein S12,Ribosomal protein S12,ribosomal protein S12,Ribosomal protein S12) b3342(30S ribosomal subunit protein S12) BN373_43641(ribosomal protein S12) t4057(30S ribosomal subunit protein S12) SL1344_3415(30S ribosomal subunit protein S12) Cluster524 1 1 1 1 1 1 1 ROD_44781(30S ribosomal subunit protein S7) ENC_25400(SSU ribosomal protein S7P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.355(30S ribosomal protein S7,30S ribosomal protein S7,Ribosomal protein S7,ribosomal protein S7,Ribosomal protein S7p/S5e) b3341(30S ribosomal subunit protein S7) BN373_43631(ribosomal protein S7) t4058(30S ribosomal subunit protein S7) SL1344_3414(30S ribosomal subunit protein S7) Cluster525 1 1 1 1 1 1 1 ROD_44851(bacterioferritin-associated ferredoxin) ENC_25380(Bacterioferritin-associated ferredoxin) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.359(Bacterioferritin-associated ferredoxin,bacterioferritin-associated ferredoxin,Fe-S cluster assembly protein NifU,BFD-like [2Fe-2S] binding domain) b3337(bacterioferritin-associated ferredoxin) BN373_43601(bacterioferritin-associated ferredoxin) t4061(bacterioferritin-associated ferredoxin) SL1344_3411(bacterioferritin-associated ferredoxin) Cluster526 1 1 1 1 1 1 1 ROD_44861(bacterioferritin) ENC_25370(bacterioferritin) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.360(Bacterioferritin,bacterioferritin,Bacterioferriti n (cytochrome b1),bacterioferritin,Ferritin-like domain) b3336(bacterioferritin, iron storage and detoxification protein) BN373_43591(bacterioferritin) t4062(bacterioferritin) SL1344_3410(bacterioferritin) Cluster527 1 1 1 1 1 1 1 ROD_45011(30S ribosomal subunit protein S10) ENC_25350(ribosomal protein S10, bacterial/organelle) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.375(30S ribosomal protein S10,30S ribosomal protein S10,ribosomal protein S10,Ribosomal protein S10p/S20e) b3321(30S ribosomal subunit protein S10) BN373_43571(ribosomal protein S10) t4064(30S ribosomal subunit protein S10) SL1344_3408(30S ribosomal subunit protein S10) Cluster528 1 1 1 1 1 1 1 ROD_45021(50S ribosomal subunit protein L3) ENC_25340(LSU ribosomal protein L3P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.376(50S ribosomal protein L3,50S ribosomal protein L3,Ribosomal protein L3,50S ribosomal protein L3,Ribosomal protein L3) b3320(50S ribosomal subunit protein L3) BN373_43561(ribosomal protein L3) t4065(50S ribosomal subunit protein L3) SL1344_3407(50S ribosomal subunit protein L3) Cluster529 1 1 1 1 1 1 1 ROD_45031(50S ribosomal subunit protein L4) ENC_25330(LSU ribosomal protein L4P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.377(50S ribosomal protein L4,50S ribosomal protein L4,50S ribosomal protein L4,Ribosomal protein L4/L1 family) b3319(50S ribosomal subunit protein L4) BN373_43551(ribosomal protein L4) t4066(50S ribosomal subunit protein L4) SL1344_3406(50S ribosomal subunit protein L4) Cluster530 1 1 1 1 1 1 1 ROD_45041(50S ribosomal subunit protein L23) ENC_25320(Ribosomal protein L23) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.378(50S ribosomal protein L23,50S ribosomal protein L23,Ribosomal protein L23,archaeal ribosomal protein L23,Ribosomal protein L23) b3318(50S ribosomal subunit protein L23) BN373_43541(ribosomal protein L23) t4067(50S ribosomal subunit protein L23) SL1344_3405(50S ribosomal subunit protein L23) Cluster531 1 1 1 1 1 1 1 ROD_45051(50S ribosomal subunit protein L2) ENC_25310(ribosomal protein L2, bacterial/organellar) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.379(50S ribosomal protein L2,50S ribosomal protein L2,Ribosomal protein L2,ribosomal protein L2,Ribosomal Proteins L2, C-terminal domain) b3317(50S ribosomal subunit protein L2) BN373_43531(ribosomal protein L2) t4068(50S ribosomal subunit protein L2) SL1344_3404(50S ribosomal subunit protein L2) Cluster532 1 1 1 1 1 1 1 ROD_45061(30S ribosomal subunit protein S19) ENC_25300(SSU ribosomal protein S19P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.380(30S ribosomal protein S19,30S ribosomal protein S19,Ribosomal protein S19,ribosomal protein S19,Ribosomal protein S19) b3316(30S ribosomal subunit protein S19) BN373_43521(ribosomal protein S19) t4069(30S ribosomal subunit protein S19) SL1344_3403(30S ribosomal subunit protein S19) Cluster533 1 1 1 1 1 1 1 ROD_45071(50S ribosomal subunit protein L22) ENC_25290(LSU ribosomal protein L22P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.381(50S ribosomal protein L22,50S ribosomal protein L22,ribosomal protein L22,Ribosomal protein L22p/L17e) b3315(50S ribosomal subunit protein L22) BN373_43511(ribosomal protein L22) t4070(50S ribosomal subunit protein L22) SL1344_3402(50s ribosomal protein l22) Cluster534 1 1 1 1 1 1 1 ROD_45081(30S ribosomal subunit protein S3) ENC_25280(SSU ribosomal protein S3P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.382(30S ribosomal protein S3,30S ribosomal protein S3,Uncharacterized conserved protein,ribosomal protein S3,Ribosomal protein S3, C-terminal domain) b3314(30S ribosomal subunit protein S3) BN373_43501(ribosomal protein S3) t4071(30S ribosomal subunit protein S3) SL1344_3401(30S ribosomal subunit protein S3) Cluster535 1 1 1 1 1 1 1 ROD_45091(50S ribosomal subunit protein L16) ENC_25270(LSU ribosomal protein L16P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.383(50S ribosomal protein L16,50S ribosomal protein L16,Ribosomal protein L16/L10E,ribosomal protein L16,Ribosomal protein L16p/L10e) b3313(50S ribosomal subunit protein L16) BN373_43491(ribosomal protein L16) t4072(50S ribosomal subunit protein L16) SL1344_3400(50S ribosomal subunit protein L16) Cluster536 1 1 1 1 1 1 1 ROD_45101(50S ribosomal subunit protein L29) ENC_25260(LSU ribosomal protein L29P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.384(50S ribosomal protein L29,50S ribosomal protein L29,Ribosomal protein L29,ribosomal protein L29,Ribosomal L29 protein) b3312(50S ribosomal subunit protein L29) BN373_43481(ribosomal protein L29) t4073(50S ribosomal subunit protein L29) SL1344_3399(50S ribosomal subunit protein L29) Cluster537 1 1 1 1 1 1 1 ROD_45111(30S ribosomal subunit protein S17) ENC_25250(30S ribosomal protein S17) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.385(30S ribosomal protein S17,30S ribosomal protein S17,30S ribosomal protein S17,Ribosomal protein S17) b3311(30S ribosomal subunit protein S17) BN373_43471(30S ribosomal protein S17) t4074(30S ribosomal subunit protein S17) SL1344_3398(30S ribosomal subunit protein S17) Cluster538 1 1 1 1 1 1 1 ROD_45112(50S ribosomal subunit protein L14) ENC_25240(LSU ribosomal protein L14P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.386(50S ribosomal protein L14,50S ribosomal protein L14,Ribosomal protein L14,ribosomal protein L14,Ribosomal protein L14p/L23e) b3310(50S ribosomal subunit protein L14) BN373_43461(50S ribosomal protein L14) t4075(50S ribosomal subunit protein L14) SL1344_3397(50S ribosomal subunit protein L14) Cluster539 1 1 1 1 1 1 1 ROD_45131(50S ribosomal subunit protein L24) ENC_25230(LSU ribosomal protein L24P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.387(50S ribosomal protein L24,50S ribosomal protein L24,ribosomal protein L24) b3309(50S ribosomal subunit protein L24) BN373_43451(ribosomal protein L24) t4076(50S ribosomal subunit protein L24) SL1344_3396(50S ribosomal subunit protein L24) Cluster540 1 1 1 1 1 1 1 ROD_45141(50S ribosomal subunit protein L5) ENC_25220(Ribosomal protein L5) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.388(50S ribosomal protein L5,50S ribosomal protein L5,Ribosomal protein L5,ribosomal L5P family C-terminus) b3308(50S ribosomal subunit protein L5) BN373_43441(ribosomal protein L5) t4077(50S ribosomal subunit protein L5) SL1344_3395(50S ribosomal subunit protein L5) Cluster541 1 1 1 1 1 1 1 ROD_45151(30S ribosomal subunit protein S14) ENC_25210(SSU ribosomal protein S14P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.389(30S ribosomal protein S14,30S ribosomal protein S14,Ribosomal protein S14p/S29e) b3307(30S ribosomal subunit protein S14) BN373_43431(ribosomal protein S14) t4078(30S ribosomal subunit protein S14) SL1344_3394(30S ribosomal subunit protein S14) Cluster542 1 1 1 1 1 1 1 ROD_45161(30S ribosomal subunit protein S8) ENC_25200(SSU ribosomal protein S8P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.390(30S ribosomal protein S8,30S ribosomal protein S8,Ribosomal protein S8,Ribosomal protein S8) b3306(30S ribosomal subunit protein S8) BN373_43421(ribosomal protein S8) t4079(30S ribosomal subunit protein S8) SL1344_3393(30S ribosomal subunit protein S8) Cluster543 1 1 1 1 1 1 1 ROD_45171(50S ribosomal subunit protein L6) ENC_25190(LSU ribosomal protein L6P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.391(50S ribosomal protein L6,50S ribosomal protein L6,ribosomal protein L6,Ribosomal protein L6) b3305(50S ribosomal subunit protein L6) BN373_43411(ribosomal protein L6) t4080(50S ribosomal subunit protein L6) SL1344_3392(50S ribosomal subunit protein L6) Cluster544 1 1 1 1 1 1 1 ROD_45181(50S ribosomal subunit protein L18) ENC_25180(LSU ribosomal protein L18P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.392(50S ribosomal protein L18,50S ribosomal protein L18,ribosomal protein L18,Ribosomal L18p/L5e family) b3304(50S ribosomal subunit protein L18) BN373_43401(ribosomal protein L18) t4081(50S ribosomal subunit protein L18) SL1344_3391(L18 Ribosomal Protein) Cluster545 1 1 1 1 1 1 1 ROD_45191(30S ribosomal subunit protein S5) ENC_25170(ribosomal protein S5, bacterial/organelle type) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.393(30S ribosomal protein S5,30S ribosomal protein S5,Ribosomal protein S5,ribosomal protein S5,Ribosomal protein S5, C-terminal domain) b3303(30S ribosomal subunit protein S5) BN373_43391(ribosomal protein S5) t4082(30S ribosomal subunit protein S5) SL1344_3390(30S ribosomal subunit protein S5) Cluster546 1 1 1 1 1 1 1 ROD_45201(50S ribosomal subunit protein L30) ENC_25160(LSU ribosomal protein L30P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.394(50S ribosomal protein L30,50S ribosomal protein L30,ribosomal protein L30,Ribosomal protein L30p/L7e) b3302(50S ribosomal subunit protein L30) BN373_43381(ribosomal protein L30) t4083(50S ribosomal subunit protein L30) SL1344_3389(50S ribosomal subunit protein L30) Cluster547 1 1 1 1 1 1 1 ROD_45211(50S ribosomal subunit protein L15) ENC_25150(LSU ribosomal protein L15P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.395(50S ribosomal protein L15,50S ribosomal protein L15,ribosomal protein L15,Ribosomal protein L18e/L15) b3301(50S ribosomal subunit protein L15) BN373_43371(ribosomal protein L15) t4084(50S ribosomal subunit protein L15) SL1344_3388(50S ribosomal subunit protein L15) Cluster548 1 1 1 1 1 1 1 ROD_45221(preprotein translocase subunit SecY) ENC_25140(protein translocase subunit secY/sec61 alpha) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.396(hypothetical protein,preprotein translocase subunit SecY,Preprotein translocase subunit SecY,preprotein translocase, SecY subunit,SecY translocase) b3300(preprotein translocase membrane subunit) BN373_43361(preprotein translocase, SecY subunit) t4085(preprotein translocase subunit) SL1344_3387(preprotein translocase subunit) Cluster549 1 1 1 1 1 1 1 ROD_45241(30S ribosomal subunit protein S11) ENC_25120(SSU ribosomal protein S11P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.399(30S ribosomal protein S11,30S ribosomal protein S11,Ribosomal protein S11,30S ribosomal protein S11,Ribosomal protein S11) b3297(30S ribosomal subunit protein S11) BN373_43341(30S ribosomal protein S11) t4088(30S ribosomal subunit protein S11) SL1344_3384(30S ribosomal subunit protein S11) Cluster550 1 1 1 1 1 1 1 ROD_45261(DNA-directed RNA polymerase alpha chain) ENC_25100(DNA-directed RNA polymerase subunit alpha) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.401(DNA-directed RNA polymerase subunit alpha,DNA-directed RNA polymerase subunit alpha,DNA-directed RNA polymerase, alpha subunit/40 kD subunit,DNA-directed RNA polymerase, alpha subunit,Bacterial RNA polymerase, alpha chain C terminal domain) b3295(RNA polymerase, alpha subunit) BN373_43321(DNA-directed RNA polymerase, alpha subunit) t4090(DNA-directed RNA polymerase alpha chain) SL1344_3382(DNA-directed RNA polymerase alpha chain) Cluster551 1 1 1 1 1 1 1 ROD_45271(50S ribosomal subunit protein L17) ENC_25090(LSU ribosomal protein L17P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.402(50S ribosomal protein L17,50S ribosomal protein L17,Ribosomal protein L17,ribosomal protein L17,Ribosomal protein L17) b3294(50S ribosomal subunit protein L17) BN373_43311(ribosomal protein L17) t4091(50S ribosomal subunit protein L17) SL1344_3381(50S ribosomal subunit protein L17) Cluster552 1 1 1 1 1 1 1 ROD_45281(conserved hypothetical protein) ENC_25080(Domain of unknown function (DUF1992).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.403(hypothetical protein,Domain of unknown function (DUF1992)) b3293(conserved protein, DUF1992 family) BN373_43301(conserved hypothetical protein) t4092(conserved hypothetical protein) SL1344_3380(conserved hypothetical protein) Cluster553 1 1 1 1 1 1 1 ROD_45291(putative Zn(II)-responsive regulator) ENC_25070(Zn(II)-responsive transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.404(Zn(II)-responsive regulator of zntA,zinc-responsive transcriptional regulator,Transcriptional regulator, effector-binding domain/component,Zn(II)-responsive transcriptional regulator,MerR, DNA binding) b3292(DNA-binding transcriptional activator in response to Zn(II)) BN373_43291(zinc-responsive transcriptional regulator) t4093(putative Zn(II)-responsive regulator) SL1344_3379(putative Zn(II)-responsive regulator) Cluster554 1 1 1 1 1 1 1 ROD_45311(large-conductance mechanosensitive channel) ENC_25050(large conductance mechanosensitive channel protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.406(Large-conductance mechanosensitive channel,large-conductance mechanosensitive channel,large conductance mechanosensitive channel protein,Large-conductance mechanosensitive channel, MscL) b3291(mechanosensitive channel protein, high conductance) BN373_43271(large conductance mechanosensitive channel protein) t4094(large-conductance mechanosensitive channel) SL1344_3377(large-conductance mechanosensitive channel) Cluster555 1 1 1 1 1 1 1 ROD_45321(potassium transport protein) ENC_25040(K+ transport systems, NAD-binding component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.407(Trk system potassium uptake protein trkA,potassium transporter peripheral membrane component,Kef-type K+ transport system, predicted NAD-binding component,xanthine dehydrogenase accessory protein XdhC,TrkA-N domain) b3290(NAD-binding component of TrK potassium transporter) BN373_43261(Trk system potassium uptake protein TrkA) t4095(potassium transport protein) SL1344_3376(potassium transport protein) Cluster556 1 1 1 1 1 1 1 ROD_45331(ribosomal RNA small subunit methyltransferase B) ENC_25030(16S rRNA m(5)C-967 methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.408(Ribosomal RNA small subunit methyltransferase B,16S rRNA methyltransferase B,tRNA and rRNA cytosine-C5-methylases,ribosomal RNA small subunit methyltransferase B,NOL1/NOP2/sun family) b3289(16S rRNA m(5)C967 methyltransferase, S-adenosyl-L-methionine-dependent) BN373_43251(ribosomal RNA small subunit methyltransferase B) t4096(sun protein) SL1344_3375(16S rRNA methyltransferase) Cluster557 1 1 1 1 1 1 1 ROD_45361(conserved hypothetical protein) ENC_25000(DNA protecting protein DprA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.411(hypothetical protein,hypothetical protein,DNA protecting protein DprA,DNA recombination-mediator protein A) b4473(conserved protein) BN373_43221(DNA protecting protein DprA) t4099(conserved hypothetical protein) SL1344_3372(conserved hypothetical protein) Cluster558 1 1 1 1 1 1 1 ROD_45371(conserved hypothetical protein) ENC_24990(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.412(hypothetical protein,Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF494)) b3284(conserved protein) BN373_43211(protein Smg) t4100(conserved hypothetical protein) SL1344_3371(conserved hypothetical protein) Cluster559 1 1 1 1 1 1 1 ROD_45401(shikimate dehydrogenase) ENC_24960(shikimate dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.415(Shikimate dehydrogenase,shikimate 5-dehydrogenase,5-enolpyruvylshikimate-3-phosphate synthase,shikimate 5-dehydrogenase,Shikimate dehydrogenase substrate binding domain) b3281(dehydroshikimate reductase, NAD(P)-binding) BN373_43181(shikimate 5-dehydrogenase) t4103(shikimate dehydrogenase) SL1344_3368(shikimate dehydrogenase) Cluster560 1 1 1 1 1 1 1 ROD_45411(conserved hypothetical protein) ENC_24950(Protein of unknown function (DUF1488).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.416(Protein of unknown function (DUF1488)) b3280(conserved protein) BN373_43171(conserved hypothetical protein) t4104(conserved hypothetical protein) SL1344_3367(conserved hypothetical protein) Cluster561 1 1 1 1 1 1 1 ROD_45421(putative transferase) ENC_24940(Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.417(hypothetical protein,carnitine operon protein CaiE,Acetyltransferase (isoleucine patch superfamily),phenylacetic acid degradation protein PaaY,Bacterial transferase hexapeptide (six repeats)) b3279(conserved protein) BN373_43161(carbonic anhydrase family protein) t4105(putative transferase) SL1344_3366(putative transferase) Cluster562 1 1 1 1 1 1 1 ROD_45471(putative lipoprotein) ENC_35170(Prokaryotic membrane lipoprotein lipid attachment site.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.427(hypothetical protein) b3267(predicted outer membrane protein) BN373_43151(putative lipoprotein) t3305(possible lipoprotein) SL1344_3365(possible lipoprotein) Cluster563 1 1 1 1 1 1 1 ROD_45531(DNA-binding protein) ENC_35110(Factor for inversion stimulation Fis, transcriptional activator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.433(Hin recombinational enhancer-binding protein,global DNA-binding transcriptional dual regulator Fis,Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,nitrogen regulation protein NR(I),Bacterial regulatory protein, Fis family) b3261(global DNA-binding transcriptional dual regulator) BN373_43111(DNA-binding protein fis) t3300(Fis DNA-binding protein) SL1344_3358(Fis DNA-binding protein) Cluster564 1 1 1 1 1 1 1 ROD_45541(tRNA-dihydrouridine synthase B) ENC_35100(tRNA-U20-dihydrouridine synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.434(Probable tRNA-dihydrouridine synthase,tRNA-dihydrouridine synthase B,Predicted permeases,putative TIM-barrel protein, nifR3 family,Dihydrouridine synthase (Dus)) b3260(tRNA-dihydrouridine synthase B) BN373_43101(tRNA-dihydrouridine synthase B) t3299(conserved hypothetical protein) SL1344_3357(conserved hypothetical protein) Cluster565 1 1 1 1 1 1 1 ROD_45551(ribosomal protein L11 methyltransferase) ENC_35080([LSU ribosomal protein L11P]-lysine N-methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.435(Ribosomal protein L11 methyltransferase,ribosomal protein L11 methyltransferase,Ribosomal protein L11 methylase,ribosomal protein L11 methyltransferase,Ribosomal protein L11 methyltransferase (PrmA)) b3259(methyltransferase for 50S ribosomal subunit protein L11) BN373_43091(ribosomal protein L11 methyltransferase) t3298(ribosomal protein L11 methyltransferase) SL1344_3356(ribosomal protein L11 methyltransferase) Cluster566 1 1 1 1 1 1 1 ROD_45561(sodium/pantothenate symporter (pantothenate permease)) ENC_35070(sodium/pantothenate symporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.436(Pantothenate permease,sodium/panthothenate symporter,Na+/panthothenate symporter,sodium/pantothenate symporter,Sodium:solute symporter family) b3258(pantothenate:sodium symporter) BN373_43081(sodium/panthothenate symporter) t3297(sodium/pantothenate symporter) SL1344_3355(sodium/pantothenate symporter (pantothenate permease)) Cluster567 1 1 1 1 1 1 1 ROD_45571(putative membrane protein) ENC_35060(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.437(hypothetical protein,Predicted membrane protein,Protein of unknown function (DUF997)) b3257(conserved inner membrane protein) BN373_43071(conserved hypothetical protein) t3296(conserved hypothetical protein) SL1344_3354(conserved hypothetical protein) Cluster568 1 1 1 1 1 1 1 ROD_45591(biotin carboxyl carrier protein of acetyl-CoA carboxylase) ENC_35030(biotin carboxyl carrier protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.447(Biotin carboxyl carrier protein of acetyl-CoA carboxylase,acetyl-CoA carboxylase biotin carboxyl carrier protein subunit,Biotin carboxyl carrier protein,acetyl-CoA carboxylase, biotin carboxyl carrier protein,Biotin-requiring enzyme) b3255(acetyl CoA carboxylase, BCCP subunit) BN373_43051(acetyl-CoA carboxylase, biotin carboxyl carrier protein) t3294(biotin carboxyl carrier protein) SL1344_3352(biotin carboxyl carrier protein) Cluster569 1 1 1 1 1 1 1 ROD_45621(putative oxidoreductase) ENC_35000(Sulfite oxidase and related enzymes) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1854(Sulfoxide reductase catalytic subunit yedY precursor,TMAO/DMSO reductase,Oxidoreductase molybdopterin binding domain) b1971(membrane-anchored, periplasmic TMAO, DMSO reductase) BN373_43021(oxidoreductase, molybdopterin binding) t3292(conserved hypothetical protein) SL1344_3350(conserved hypothetical protein) Cluster570 1 1 1 1 1 1 1 ROD_45641(putative signal transduction protein) ENC_34980(diguanylate cyclase/phosphodiesterase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.449(Regulator of CsrB and CsrC decay CsrD,regulatory protein CsrD,MHYT domain (predicted integral membrane sensor domain),diguanylate cyclase (GGDEF) domain,EAL domain) b3252(targeting factor for csrBC sRNA degradation) BN373_43011(putative cyclic diguanylate phosphodiesterase) t3290(putative lipoprotein) SL1344_3348(putative lipoprotein) Cluster571 1 1 1 1 1 1 1 ROD_45651(rod shape-determining protein) ENC_34970(Actin-like ATPase involved in cell morphogenesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.450(Rod shape-determining protein MreB,rod shape-determining protein MreB,Ethanolamine utilization protein, possible chaperonin,cell shape determining protein, MreB/Mrl family,MreB/Mbl protein) b3251(cell wall structural complex MreBCD, actin-like component MreB) BN373_43001(rod shape-determining protein MreB) t3289(rod shape-determining protein) SL1344_3346(rod shape-determining protein) Cluster572 1 1 1 1 1 1 1 ROD_45661(rod shape-determining protein) ENC_34950(rod shape-determining protein MreC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.451(rod shape-determining protein MreC,rod shape-determining protein MreC,rod shape-determining protein MreC) b3250(cell wall structural complex MreBCD transmembrane component MreC) BN373_42991(rod shape-determining protein MreC) t3288(rod shape-determining protein) SL1344_3345(rod shape-determining protein) Cluster573 1 1 1 1 1 1 1 ROD_45681(Maf-like protein protein) ENC_34930(MAF protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.453(Maf-like protein yhdE,Maf-like protein,Nucleotide-binding protein implicated in inhibition of septum formation,septum formation protein Maf,Maf-like protein) b3248(Maf-like protein) BN373_42971(septum formation protein Maf) t3286(conserved hypothetical protein) SL1344_3343(conserved hypothetical protein) Cluster574 1 1 1 1 1 1 1 ROD_45691(ribonuclease G (cytoplasmic axial filament protein)) ENC_34910(RNAse G) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.454(Ribonuclease G,ribonuclease G,Ribonucleases G and E,ribonuclease, Rne/Rng family,Ribonuclease E/G family) b3247(ribonuclease G) BN373_42961(ribonuclease G) t3285(ribonuclease G) SL1344_3342(ribonuclease G) Cluster575 1 1 1 1 1 1 1 ROD_45711(TldD protein) ENC_34890(microcin-processing peptidase 2. Unknown type peptidase. MEROPS family U62) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.456(hypothetical protein,protease TldD,Predicted Zn-dependent proteases and their inactivated homologs,Putative modulator of DNA gyrase) b3244(predicted peptidase) BN373_42941(protein TldD) t3283(tldD protein) SL1344_3340(TldD protein) Cluster576 1 1 1 1 1 1 1 ROD_45721(LysR-family transcriptional regulator) ENC_34880(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.457(D-malate degradation protein R,transcriptional regulator,ABC-type uncharacterized transport system, periplasmic component,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b3243(transcriptional regulator for aaeXAB operon) BN373_42931(transcriptional activator AaeR) t3282(probable LysR-family transcriptional regulator) SL1344_3339(probable LysR-family transcriptional regulator) Cluster577 1 1 1 1 1 1 1 ROD_45731(putative membrane protein) ENC_34870(Protein of unknown function (DUF1656).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.458(efflux system membrane protein,Protein of unknown function (DUF1656)) b3242(membrane protein of efflux system) BN373_42921(protein AaeX) t3281(conserved hypothetical protein) SL1344_3338(conserved hypothetical protein) Cluster578 1 1 1 1 1 1 1 ROD_45741(p-hydroxybenzoic acid efflux pump subunit A) ENC_34860(Multidrug resistance efflux pump) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.459(Inner membrane protein yibH,p-hydroxybenzoic acid efflux subunit AaeA,efflux pump membrane protein,HlyD family secretion protein) b3241(p-hydroxybenzoic acid efflux system component) BN373_42911(p-hydroxybenzoic acid efflux pump subunit AaeA) t3280(possible exported protein) SL1344_3337(possible exported protein) Cluster579 1 1 1 1 1 1 1 ROD_45751(p-hydroxybenzoic acid efflux pump subunit B) ENC_34850(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.460(p-hydroxybenzoic acid efflux pump subunit AaeB,p-hydroxybenzoic acid efflux subunit AaeB,Predicted membrane protein,integral membrane protein, YccS/YhfK family,Fusaric acid resistance protein family) b3240(p-hydroxybenzoic acid efflux system component) BN373_42901(p-hydroxybenzoic acid efflux pump subunit AaeB) t3279(putative membrane protein) SL1344_3336(putative membrane protein) Cluster580 1 1 1 1 1 1 1 ROD_45771(conserved hypothetical protein) ENC_34830(Barstar, RNAse (barnase) inhibitor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.461(hypothetical protein,Barstar (barnase inhibitor)) b3239(predicted barnase inhibitor) BN373_42891(conserved hypothetical protein) t3278(conserved hypothetical protein) SL1344_3335(conserved hypothetical protein) Cluster581 1 1 1 1 1 1 1 ROD_45851(Putative exported protein) ENC_34820(Protein of unknown function (DUF1471).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.462(Multiple stress resistance protein BhsA precursor,hypothetical protein,Protein of unknown function (DUF1471)) b3238(conserved protein) BN373_42871(protein YcfR) t3276(conserved hypothetical protein) SL1344_3333(conserved hypothetical protein) Cluster582 1 1 1 1 1 1 1 ROD_45861(arginine repressor) ENC_34810(transcriptional regulator, ArgR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.463(Arginine repressor,arginine repressor,arginine repressor,Arginine repressor, DNA binding domain) b3237(DNA-binding transcriptional dual regulator, L-arginine-binding) BN373_42861(arginine repressor) t3275(arginine repressor) SL1344_3332(arginine repressor) Cluster583 1 1 1 1 1 1 1 ROD_45871(malate dehydrogenase) ENC_34800(malate dehydrogenase, NAD-dependent) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.464(Malate dehydrogenase,malate dehydrogenase,malate dehydrogenase, NAD-dependent,lactate/malate dehydrogenase, NAD binding domain) b3236(malate dehydrogenase, NAD(P)-binding) BN373_42851(malate dehydrogenase, NAD-dependent) t3274(malate dehydrogenase) SL1344_3331(malate dehydrogenase) Cluster584 1 1 1 1 1 1 1 ROD_45881(protease) ENC_34790(DegS peptidase. Serine peptidase. MEROPS family S01B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.465(Serine endoprotease DegS precursor,serine endoprotease,Predicted protease with the C-terminal PDZ domain,periplasmic serine peptidase DegS,Trypsin) b3235(serine endoprotease, periplasmic) BN373_42841(periplasmic serine peptidase DegS) t3265(serine protease) SL1344_3321(serine protease) Cluster585 1 1 1 1 1 1 1 ROD_45891(protease) ENC_34780(DegQ peptidase. Serine peptidase. MEROPS family S01B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.466(Periplasmic pH-dependent serine endoprotease DegQ precursor,serine endoprotease,Predicted protease with the C-terminal PDZ domain,peptidase Do,PDZ domain (Also known as DHR or GLGF)) b3234(serine endoprotease, periplasmic) BN373_42831(serine peptidase DegQ) t3264(serine protease) SL1344_3320(serine protease) Cluster586 1 1 1 1 1 1 1 ROD_45901(putative membrane protein) ENC_34760(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.467(Putative cytochrome d ubiquinol oxidase subunit 3,hypothetical protein,Protein of unknown function (DUF1043)) b3233(conserved protein) BN373_42821(conserved hypothetical protein) t3263(conserved hypothetical protein) SL1344_3319(conserved hypothetical protein) Cluster587 1 1 1 1 1 1 1 ROD_45911(putative ATP/GTP-binding protein) ENC_34750(Predicted ATPase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.468(hypothetical protein,AFG1-like ATPase) b3232(conserved protein with nucleoside triphosphate hydrolase domain) BN373_42811(ATPase, AFG1 family) t3262(putative ATP/GTP-binding protein) SL1344_3318(putative ATP/GTP-binding protein) Cluster588 1 1 1 1 1 1 1 ROD_45921(50S ribosomal subunit protein L13) ENC_34740(LSU ribosomal protein L13P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.469(50S ribosomal protein L13,50S ribosomal protein L13,Ribosomal protein L13,ribosomal protein L13,Ribosomal protein L13) b3231(50S ribosomal subunit protein L13) BN373_42801(ribosomal protein L13) t3261(50S ribosomal subunit protein L13) SL1344_3317(50S ribosomal subunit protein L13) Cluster589 1 1 1 1 1 1 1 ROD_45931(30S ribosomal subunit protein S9) ENC_34730(SSU ribosomal protein S9P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.470(30S ribosomal protein S9,30S ribosomal protein S9,Ribosomal protein S9,archaeal ribosomal protein S9P,Ribosomal protein S9/S16) b3230(30S ribosomal subunit protein S9) BN373_42791(ribosomal protein S9) t3260(30S ribosomal subunit protein S9) SL1344_3316(30S ribosomal subunit protein S9) Cluster590 1 1 1 1 1 1 1 ROD_45941(stringent starvation protein A) ENC_34710(Glutathione S-transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.471(Stringent starvation protein A,stringent starvation protein A,maleylacetoacetate isomerase,Glutathione S-transferase, N-terminal domain) b3229(stringent starvation protein A) BN373_42781(stringent starvation protein A) t3259(stringent starvation protein A) SL1344_3314(stringent starvation protein A) Cluster591 1 1 1 1 1 1 1 ROD_45951(stringent starvation protein B) ENC_34700(Stringent starvation protein B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.472(Stringent starvation protein B,ClpXP protease specificity-enhancing factor,Stringent starvation protein B) b3228(ClpXP protease specificity-enhancing factor) BN373_42771(stringent starvation protein B) t3258(stringent starvation protein B) SL1344_3313(stringent starvation protein B) Cluster592 1 1 1 1 1 1 1 ROD_46061(radical SAM superfamily protein) ENC_34580(radical SAM protein, TIGR01212 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.481(coproporphyrinogen III oxidase,radical SAM protein,Radical SAM superfamily) b3211(predicted Fe-S oxidoreductase) BN373_42731(radical SAM protein, TIGR01212 family) t3246(conserved hypothetical protein) SL1344_3301(conserved hypothetical protein) Cluster593 1 1 1 1 1 1 1 ROD_46081(putative dehydrogenase) ENC_12060(Threonine dehydrogenase and related Zn-dependent dehydrogenases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2304(Sorbitol dehydrogenase,putative oxidoreductase,Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase,L-threonine 3-dehydrogenase,Alcohol dehydrogenase GroES-like domain) b1580(predicted oxidoreductase, Zn-dependent and NAD(P)-binding) BN373_42711(oxidoreductase, zinc-binding dehydrogenase family) t1427(starvation sensing protein RspB) SL1344_1436(starvation sensing protein RspB) Cluster594 1 1 1 1 1 1 1 ROD_46101(aerobic respiration control protein (bifunctional two-component sensor kinase/response regulator)) ENC_34470(PAS/PAC sensor hybrid histidine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.482(Aerobic respiration control sensor protein ArcB,aerobic respiration control sensor protein ArcB,Uncharacterized domain of BarA-like signal transduction histidine kinases,TMAO reductase sytem sensor TorS,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b3210(aerobic respiration control sensor histidine protein kinase, cognate to two-component response regulators ArcA and RssB) BN373_42691(aerobic respiration control sensor protein ArcB) t3245(aerobic respiration control sensor protein) SL1344_3300(aerobic respiration control sensor protein) Cluster595 1 1 1 1 1 1 1 ROD_46111(enhancing lycopene biosynthesis protein 2 (sigma cross-reacting protein 27A)) ENC_34450(Uncharacterized protein involved in an early stage of isoprenoid biosynthesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.484(Sigma cross-reacting protein 27A,isoprenoid biosynthesis protein with amidotransferase-like domain,DJ-1/PfpI family) b3209(isoprenoid biosynthesis protein with amidotransferase-like domain) BN373_42681(enhancing lycopene biosynthesis protein 2) t3244(conserved hypothetical protein) SL1344_3299(conserved hypothetical protein) Cluster596 1 1 1 1 1 1 1 ROD_46121(monofunctional biosynthetic peptidoglycan transglycosylase) ENC_34440(monofunctional biosynthetic peptidoglycan transglycosylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.485(Penicillin-binding protein 4 precursor,monofunctional biosynthetic peptidoglycan transglycosylase,Membrane carboxypeptidase/penicillin-binding protein,monofunctional biosynthetic peptidoglycan transglycosylase,Transglycosylase) b3208(biosynthetic peptidoglycan transglycosylase) BN373_42671(monofunctional biosynthetic peptidoglycan transglycosylase) t3243(monofunctional biosynthetic peptidoglycan transglycosylase) SL1344_3298(monofunctional biosynthetic peptidoglycan transglycosylase) Cluster597 1 1 1 1 1 1 1 ROD_46141(phosphocarrier protein) ENC_34430(Phosphotransferase System HPr (HPr) Family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.487(Phosphocarrier protein NPr,phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr),Uncharacterized protein conserved in bacteria,phosphocarrier, HPr family,PTS HPr component phosphorylation site) b3206(phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr)) BN373_42661(phosphocarrier protein NPr) t3241(phosphocarrier protein) SL1344_3296(phosphocarrier protein (nitrogen related hpr)) Cluster598 1 1 1 1 1 1 1 ROD_46151(putative ATPase) ENC_34420(Predicted P-loop-containing kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.488(hypothetical protein,glmZ(sRNA)-inactivating NTPase,Predicted P-loop-containing kinase,P-loop ATPase protein family) b3205(glmZ(sRNA)-inactivating NTPase, glucosamine-6-phosphate regulated) BN373_42651(putative P-loop ATPase) t3240(conserved hypothetical protein) SL1344_3295(conserved hypothetical protein) Cluster599 1 1 1 1 1 1 1 ROD_46161(nitrogen regulatory protein includes PTS system EIIA component]) ENC_34410(PTS IIA-like nitrogen-regulatory protein PtsN) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.489(Nitrogen regulatory protein,PTS system sugar transporter subunit IIA,PTS IIA-like nitrogen-regulatory protein PtsN,Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2) b3204(sugar-specific enzyme IIA component of PTS) BN373_42641(PTS IIA-like nitrogen-regulatory protein PtsN) t3239(nitrogen regulatory IIA protein) SL1344_3294(nitrogen regulatory IIA protein) Cluster600 1 1 1 1 1 1 1 ROD_46171(probable sigma(54) modulation protein) ENC_34400(ribosomal subunit interface protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.490(hypothetical protein,ribosome hibernation promoting factor HPF,ribosomal subunit interface protein,Sigma 54 modulation protein / S30EA ribosomal protein) b3203(ribosome hibernation promoting factor HPF; stabilizes 70S dimers (100S)) BN373_42631(ribosomal subunit interface protein) t3238(probable sigma(54) modulation protein) SL1344_3293(probable sigma(54) modulation protein) Cluster601 1 1 1 1 1 1 1 ROD_46181(RNA polymerase sigma-54 factor (sigma-N)) ENC_34390(RNA polymerase, sigma 54 subunit, RpoN/SigL) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.491(RNA polymerase factor sigma-54,DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog,RNA polymerase sigma-54 factor,Sigma-54 factor, core binding domain) b3202(RNA polymerase, sigma 54 (sigma N) factor) BN373_42621(RNA polymerase sigma-54 factor) t3237(RNA polymerase sigma-54 factor) SL1344_3292(RNA polymerase sigma-54 factor (sigma-N)) Cluster602 1 1 1 1 1 1 1 ROD_46191(putative organic solvent tolerance ABC transporter, ATP-binding protein) ENC_34380(ABC-type (unclassified) transport system, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.492(Lipopolysaccharide export system ATP-binding protein LptB,lipopolysaccharide ABC transporter ATP-binding protein,Uncharacterized protein conserved in bacteria,daunorubicin resistance ABC transporter, ATP-binding protein,ABC transporter) b3201(lipopolysaccharide export ABC transporter ATP-binding protein of the LptBFGC export complex) BN373_42611(lipopolysaccharide ABC transporter, ATP-binding protein) t3236(probable ABC transport protein, ATP-binding component) SL1344_3291(probable ABC transport protein, ATP-binding component) Cluster603 1 1 1 1 1 1 1 ROD_46201(putative organic solvent tolerance protein) ENC_34370(lipopolysaccharide transport periplasmic protein LptA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.493(Lipopolysaccharide export system protein lptA precursor,lipopolysaccharide transport periplasmic protein LptA,Uncharacterized protein conserved in bacteria,lipopolysaccharide transport periplasmic protein LptA,OstA-like protein) b3200(periplasmic LPS-binding protein) BN373_42601(lipopolysaccharide ABC transporter, periplasmic lipopolysaccharide-binding protein) t3235(conserved hypothetical protein) SL1344_3290(conserved hypothetical protein) Cluster604 1 1 1 1 1 1 1 ROD_46211(putative organic solvent tolerance protein) ENC_34360(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.494(Lipopolysaccharide export system protein lptC,lipopolysaccharide exporter periplasmic protein,Uncharacterized protein conserved in bacteria,Lipopolysaccharide-assembly, LptC-related) b3199(lipopolysaccharide export, IM-tethered periplasmic protein of the LptBFGC export complex) BN373_42591(conserved hypothetical protein) t3234(possible exported protein) SL1344_3289(possible exported protein) Cluster605 1 1 1 1 1 1 1 ROD_46221(3-deoxy-d-manno-octulosonate 8-phosphate phosphatase) ENC_34350(HAD-superfamily hydrolase, subfamily IIIA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.495(3-deoxy-D-manno-octulosonate 8-phosphate phosphatas KdsC,3-deoxy-D-manno-octulosonate 8-phosphate phosphatase,3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family,haloacid dehalogenase-like hydrolase) b3198(3-deoxy-D-manno-octulosonate 8-phosphate phosphatase) BN373_42581(3-deoxy-manno-octulosonate-8-phosphatase) t3233(conserved hypothetical protein) SL1344_3288(conserved hypothetical protein) Cluster606 1 1 1 1 1 1 1 ROD_46231(arabinose 5-phosphate isomerase) ENC_34340(KpsF/GutQ family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.496(Arabinose 5-phosphate isomerase KdsD,D-arabinose 5-phosphate isomerase,Predicted signal-transduction protein containing cAMP-binding and CBS domains,sugar isomerase, KpsF/GutQ family,SIS domain) b3197(D-arabinose 5-phosphate isomerase) BN373_42571(arabinose 5-phosphate isomerase) t3232(conserved hypothetical protein) SL1344_3287(conserved hypothetical protein) Cluster607 1 1 1 1 1 1 1 ROD_46241(putative membrane protein) ENC_34330(K+-dependent Na+/Ca+ exchanger related-protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.497(Inner membrane protein yrbG,putative calcium/sodium:proton antiporter,Ca2+/H+ antiporter,K+-dependent Na+/Ca+ exchanger homolog,Sodium/calcium exchanger protein) b3196(predicted calcium/sodium:proton antiporter) BN373_42561(sodium/calcium exchanger protein) t3231(putative membrane protein) SL1344_3286(putative membrane protein) Cluster608 1 1 1 1 1 1 1 ROD_46251(putative organic solvent tolerance ABC-transporter, ATP-binding component) ENC_34320(ABC-type transport system involved in resistance to organic solvents, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.498(Probable phospholipid import ATP-binding protein MlaF,putative ABC transporter ATP-binding protein YrbF,ABC-type spermidine/putrescine transport systems, ATPase components,glycine betaine/L-proline transport ATP binding subunit,ABC transporter) b3195(ABC transporter maintaining OM lipid asymmetry, ATP-binding protein) BN373_42551(ABC transporter, ATP-binding protein) t3230(possible ABC-transport protein, ATP-binding component) SL1344_3285(possible ABC-transport protein, ATP-binding component) Cluster609 1 1 1 1 1 1 1 ROD_46261(putative organic solvent tolerance protein) ENC_34310(conserved hypothetical integral membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.499(Probable phospholipid ABC transporter permease protein mlaE,conserved hypothetical protein,Domain of unknown function DUF140) b3194(ABC transporter maintaining OM lipid asymmetry, inner membrane permease protein) BN373_42541(putative membrane protein) t3229(putative membrane protein) SL1344_3284(putative membrane protein) Cluster610 1 1 1 1 1 1 1 ROD_46271(putative organic solvent tolerance protein) ENC_34300(ABC-type transport system involved in resistance to organic solvents, periplasmic component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.500(Probable phospholipid ABC transporter-binding protein mlaD,virulence factor Mce family protein,mce related protein) b3193(ABC transporter maintaining OM lipid asymmetry, anchored periplasmic binding protein) BN373_42531(mce family protein) t3228(possible exported protein) SL1344_3283(possible exported protein) Cluster611 1 1 1 1 1 1 1 ROD_46281(putative organic solvent tolerance protein) ENC_34290(ABC-type transport system involved in resistance to organic solvents, auxiliary component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.501(Probable phospholipid-binding protein mlaC precursor,ABC transporter periplasmic binding protein MlaC,hopanoid biosynthesis associated membrane protein HpnM,Toluene tolerance, Ttg2) b3192(ABC transporter maintaining OM lipid asymmetry, periplasmic binding protein) BN373_42521(toluene tolerance protein Ttg2D) t3227(possible exported protein) SL1344_3282(possible exported protein) Cluster612 1 1 1 1 1 1 1 ROD_46291(putative anti-sigma factor antagonist) ENC_34280(Predicted NTP binding protein (contains STAS domain)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.502(Probable phospholipid ABC transporter-binding protein mlaB,Predicted NTP binding protein (contains STAS domain)) b3191(ABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component) BN373_42511(conserved hypothetical protein) t3226(possible anti-sigma factor antagonist) SL1344_3281(possible anti-sigma factor antagonist) Cluster613 1 1 1 1 1 1 1 ROD_46301(conserved hypothetical protein) ENC_34270(Predicted transcriptional regulator, BolA superfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.503(hypothetical protein,transcriptional regulator BolA,Predicted transcriptional regulator, BolA superfamily,BolA-like protein) b3190(predicted DNA-binding transcriptional regulator, BolA family) BN373_42501(BolA/YrbA family protein) t3225(conserved hypothetical protein) SL1344_3280(conserved hypothetical protein) Cluster614 1 1 1 1 1 1 1 ROD_46311(UDP-N-acetylglucosamine L-carboxyvinyltransferase) ENC_34260(UDP-N-acetylglucosamine 1-carboxyvinyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.504(UDP-N-acetylglucosamine 1-carboxyvinyltransferase,UDP-N-acetylglucosamine 1-carboxyvinyltransferase,ATP phosphoribosyltransferase,UDP-N-acetylglucosamine 1-carboxyvinyltransferase,EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)) b3189(UDP-N-acetylglucosamine 1-carboxyvinyltransferase) BN373_42491(UDP-N-acetylglucosamine 1-carboxyvinyltransferase) t3224(UDP-N-acetylglucosamine 1-carboxyvinyltransferase) SL1344_3279(UDP-N-acetylglucosamine 1-carboxyvinyltransferase) Cluster615 1 1 1 1 1 1 1 ROD_46331(octaprenyl-diphosphate synthase) ENC_34240(Geranylgeranyl pyrophosphate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.506(Octaprenyl-diphosphate synthase,octaprenyl diphosphate synthase,Geranylgeranyl pyrophosphate synthase,solanesyl diphosphate synthase,Polyprenyl synthetase) b3187(octaprenyl diphosphate synthase) BN373_42471(octaprenyl-diphosphate synthase) t3222(octaprenyl-diphosphate synthase) SL1344_3277(octaprenyl-diphosphate synthase) Cluster616 1 1 1 1 1 1 1 ROD_46342(50S ribosomal subunit protein L21) ENC_34230(LSU ribosomal protein L21P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.507(50S ribosomal protein L21,50S ribosomal protein L21,ribosomal protein L21,Ribosomal prokaryotic L21 protein) b3186(50S ribosomal subunit protein L21) BN373_42461(ribosomal protein L21) t3221(50S ribosomal subunit protein L21) SL1344_3276(50S ribosomal subunit protein L21) Cluster617 1 1 1 1 1 1 1 ROD_46351(50S ribosomal subunit protein L27) ENC_34220(LSU ribosomal protein L27P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.508(50S ribosomal protein L27,50S ribosomal protein L27,Ribosomal protein L27,ribosomal protein L27,Ribosomal L27 protein) b3185(50S ribosomal subunit protein L27) BN373_42451(ribosomal protein L27) t3220(50S ribosomal subunit protein L27) SL1344_3275(50S ribosomal subunit protein L27) Cluster618 1 1 1 1 1 1 1 ROD_46361(putative membrane protein) ENC_34210(Predicted permeases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.509(Uncharacterized inner membrane transporter yhbE,Predicted permeases,carboxylate/amino acid/amine transporter,EamA-like transporter family) b3184(predicted inner membrane permease) BN373_42441(putative transport protein) t3219(putative membrane protein) SL1344_3274(putative membrane protein) Cluster619 1 1 1 1 1 1 1 ROD_46371(probable GTP-binding protein) ENC_34200(Obg family GTPase CgtA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.510(GTP-binding protein Obg,GTPase CgtA,Predicted GTPase, probable translation factor,Obg family GTPase CgtA,GTP1/OBG) b3183(GTPase involved in cell partioning and DNA repair) BN373_42431(GTP-binding protein Obg/CgtA) t3218(probable GTP-binding protein) SL1344_3273(probable GTP-binding protein) Cluster620 1 1 1 1 1 1 1 ROD_46391(penicillin-binding protein 4 [includes: D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine-endopeptidase]) ENC_34170(D-Ala-D-Ala peptidase C. Serine peptidase. MEROPS family S13) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.511(D-alanyl-D-alanine carboxypeptidase dacB precursor,D-alanyl-D-alanine carboxypeptidase/endopeptidase,D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase,D-Ala-D-A la carboxypeptidase 3 (S13) family) b3182(D-alanyl-D-alanine carboxypeptidase) BN373_42421(D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase) t3217(penicillin-binding protein) SL1344_3272(Penicillin-binding protein (D-alanyl-D-alanine carboxypeptidase)) Cluster621 1 1 1 1 1 1 1 ROD_46401(transcription elongation factor) ENC_34160(transcription elongation factor GreA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.513(Transcript cleavage factor greA,transcription elongation factor GreA,Transcription elongation factor,transcription elongation factor GreA,domain) b3181(transcript cleavage factor) BN373_42411(transcription elongation factor GreA) t3216(transcription elongation factor) SL1344_3271(transcription elongation factor) Cluster622 1 1 1 1 1 1 1 ROD_46411(conserved hypothetical protein) ENC_34150(conserved hypothetical protein TIGR00253) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.514(RNA-binding protein YhbY,RNA-binding protein YhbY,putative RNA-binding protein, YhbY family,CRS1 / YhbY (CRM) domain) b3180(RNA binding protein associated with pre-50S ribosomal subunits) BN373_42401(putative RNA-binding protein) t3215(conserved hypothetical protein) SL1344_3270(conserved hypothetical protein) Cluster623 1 1 1 1 1 1 1 ROD_46421(cell division protein) ENC_34140(23S rRNA Um-2552 2'-O-methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.515(Ribosomal RNA large subunit methyltransferase E,23S rRNA methyltransferase J,Predicted RNA-binding protein, contains TRAM domain,ribosomal RNA large subunit methyltransferase J,FtsJ-like methyltransferase) b3179(23S rRNA U2552 ribose 2'-O-methyltransferase, SAM-dependent) BN373_42391(ribosomal RNA large subunit methyltransferase J) t3214(cell division protein) SL1344_3269(cell division protein) Cluster624 1 1 1 1 1 1 1 ROD_46431(cell division protein) ENC_34130(membrane protease FtsH catalytic subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.516(ATP-dependent zinc metalloprotease FtsH,ATP-dependent metalloprotease,Ribosome-associated chaperone zuotin,ATP-dependent metallopeptidase HflB,Peptidase family M41) b3178(protease, ATP-dependent zinc-metallo) BN373_42381(ATP-dependent metallopeptidase HflB) t3213(cell division protein) SL1344_3268(cell division protein) Cluster625 1 1 1 1 1 1 1 ROD_46441(dihydropteroate synthase) ENC_34120(Dihydropteroate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.517(Dihydropteroate synthase,dihydropteroate synthase,dihydropteroate synthase,Pterin binding enzyme) b3177(7,8-dihydropteroate synthase) BN373_42371(dihydropteroate synthase) t3212(dihydropteroate synthase) SL1344_3266(dihydropteroate synthase) Cluster626 1 1 1 1 1 1 1 ROD_46451(phosphoglucosamine mutase) ENC_34110(phosphoglucosamine mutase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.518(Phosphoglucosamine mutase,phosphoglucosamine mutase,Predicted glutamine amidotransferase,phosphoglucosamine mutase,Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I) b3176(phosphoglucosamine mutase) BN373_42361(phosphoglucosamine mutase) t3211(PGM/PMM-family protein) SL1344_3265(PGM/PMM-family protein) Cluster627 1 1 1 1 1 1 1 ROD_46581(protein-export membrane protein) ENC_34100(protein translocase subunit secG) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.519(Preprotein translocase band 1 subunit,preprotein translocase subunit SecG,preprotein translocase, SecG subunit,Preprotein translocase SecG subunit) b3175(preprotein translocase membrane subunit) BN373_42351(preprotein translocase, SecG subunit) t3210(export membrane protein) SL1344_3264(protein-export membrane protein) Cluster628 1 1 1 1 1 1 1 ROD_46601(argininosuccinate synthetase) ENC_34090(argininosuccinate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.522(Argininosuccinate synthase,argininosuccinate synthase,Argininosuccinate synthase,argininosuccinate synthase,Arginosuccinate synthase) b3172(argininosuccinate synthetase) BN373_42311(argininosuccinate synthase) t3208(argininosuccinate synthetase) SL1344_3262(argininosuccinate synthetase) Cluster629 1 1 1 1 1 1 1 ROD_46621(conserved hypothetical protein) ENC_34080(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.525(Ribosome maturation factor RimP,hypothetical protein,Uncharacterised BCR, YhbC family COG0779) b3170(ribosome maturation factor for 30S subunits) BN373_42301(conserved hypothetical protein) t3206(conserved hypothetical protein) SL1344_3261(conserved hypothetical protein) Cluster630 1 1 1 1 1 1 1 ROD_46631(transcription elongation protein) ENC_34070(transcription termination factor NusA/transcription termination factor NusA, C-terminal duplication) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.526(N utilization substance protein A,transcription elongation factor NusA,Transcription elongation factor,transcription termination factor NusA,NusA N-terminal domain) b3169(transcription termination/antitermination L factor) BN373_42291(transcription termination factor NusA) t3205(L factor) SL1344_3260(transcription termination/antitermination L factor) Cluster631 1 1 1 1 1 1 1 ROD_46641(translation initiation factor IF-2) ENC_34060(bacterial translation initiation factor 2 (bIF-2)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.527(Translation initiation factor IF-2,translation initiation factor IF-2,EMAP domain,translation initiation factor IF-2,Elongation factor Tu GTP binding domain) b3168(fused protein chain initiation factor 2, IF2: membrane protein/conserved protein) BN373_42281(translation initiation factor IF-2) t3204(protein chain initiation factor 2) SL1344_3259(protein chain initiation factor 2) Cluster632 1 1 1 1 1 1 1 ROD_46651(ribosome-binding factor A) ENC_34050(ribosome-binding factor A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.528(hypothetical protein,ribosome-binding factor A,ribosome-binding factor A,Ribosome-binding factor A) b3167(30s ribosome binding factor) BN373_42271(ribosome-binding factor A) t3203(ribosome-binding factor A) SL1344_3258(ribosome-binding factor A (P15B protein)) Cluster633 1 1 1 1 1 1 1 ROD_46661(tRNA pseudouridine synthase B) ENC_34040(tRNA pseudouridine synthase B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.529(tRNA pseudouridine synthase B,tRNA pseudouridine synthase B,Pseudouridine synthase,tRNA pseudouridine(55) synthase,TruB family pseudouridylate synthase (N terminal domain)) b3166(tRNA U55 pseudouridine synthase) BN373_42261(tRNA pseudouridine synthase B) t3202(tRNA pseudouridine 55 synthase) SL1344_3257(tRNA pseudouridine 55 synthase (psi55 synthase) (p35 protein)) Cluster634 1 1 1 1 1 1 1 ROD_46701(ATP-dependent RNA helicase (DEAD-box protein)) ENC_34000(ATP-dependent RNA helicase CsdA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.534(Cold-shock DEAD box protein A,ATP-dependent RNA helicase DeaD,Predicted transporter component,ATP-dependent DNA helicase RecQ,DEAD/DEAH box helicase) b3162(ATP-dependent RNA helicase) BN373_42221(cold-shock DEAD box protein A) t3198(ATP-dependent RNA helicase) SL1344_3253(ATP-dependent RNA helicase (dead-box protein)) Cluster635 1 1 1 1 1 1 1 ROD_46711(tryptophan-specific transport protein) ENC_33990(aromatic amino acid transport protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.535(Tryptophan permease,tryptophan permease,aromatic amino acid transport protein,Tryptophan/tyrosine permease family) b3161(tryptophan transporter of high affinity) BN373_42211(tryptophan-specific transport protein) t3197(probable amino acid permease) SL1344_3252(probable amino acid permease) Cluster636 1 1 1 1 1 1 1 ROD_46721(possible monooxygenase) ENC_33980(luciferase family oxidoreductase, group 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.536(Limonene 1,2-monooxygenase,hypothetical protein,luciferase family oxidoreductase, group 1,Luciferase-like monooxygenase) b3160(predicted enzyme) BN373_42201(monooxygenase, luciferase family) t3196(possible monooxygenase) SL1344_3249(possible monooxygenase) Cluster637 1 1 1 1 1 1 1 ROD_46731(putative peptidase) ENC_33970(Collagenase and related proteases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.537(putative protease,Collagenase and related proteases,Peptidase family U32) b3159(predicted protease) BN373_42191(peptidase, U32 family) t3195(conserved hypothetical protein) SL1344_3248(conserved hypothetical protein) Cluster638 1 1 1 1 1 1 1 ROD_46741(putative peptidase) ENC_33960(Collagenase and related proteases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.538(Uncharacterized protease yhbU precursor,putative protease,Collagenase and related proteases,Peptidase family U32) b3158(predicted peptidase (collagenase-like)) BN373_42181(peptidase, U32 family) t3194(putative protease) SL1344_3247(putative protease) Cluster639 1 1 1 1 1 1 1 ROD_46751(conserved hypothetical protein) ENC_33950(Putative lipid carrier protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.539(Putative lipid carrier protein,SCP-2 sterol transfer family) b3157(predicted lipid carrier protein, COG3154 family) BN373_42171(SCP-2 sterol transfer family protein) t3193(conserved hypothetical protein) SL1344_3246(conserved hypothetical protein) Cluster640 1 1 1 1 1 1 1 ROD_46761(putative acetyltransferase) ENC_33940(Predicted acetyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.540(hypothetical protein,Predicted acetyltransferase,Acetyltransferase (GNAT) family) b3156(predicted acyltransferase with acyl-CoA N-acyltransferase domain) BN373_42161(acetyltransferase, GNAT family) t3192(putative acetyltransferase) SL1344_3245(putative acetyltransferase) Cluster641 1 1 1 1 1 1 1 ROD_46771(putative nuclease) ENC_33930(Predicted endonuclease containing a URI domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.541(hypothetical protein,GIY-YIG nuclease superfamily protein,Predicted endonuclease containing a URI domain,GIY-YIG catalytic domain) b3155(conserved protein, GIY-YIG nuclease superfamily) BN373_42151(GIY-YIG catalytic domain protein) t3191(conserved hypothetical protein) SL1344_3244(conserved hypothetical protein) Cluster642 1 1 1 1 1 1 1 ROD_46781(conserved hypothetical protein) ENC_33920(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.542(hypothetical protein,Uncharacterized protein conserved in bacteria) b3154(conserved protein, UPF0306 family) BN373_42141(conserved hypothetical protein) t3190(conserved hypothetical protein) SL1344_3243(conserved hypothetical protein) Cluster643 1 1 1 1 1 1 1 ROD_46791(putative general stress protein) ENC_33910(intracellular protease, PfpI family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.543(hypothetical protein,oxidative-stress-resistance chaperone,intracellular protease, PfpI family,DJ-1/PfpI family) b3153(stress-resistance protein) BN373_42131(intracellular protease, PfpI family) t3189(conserved hypothetical protein) SL1344_3242(conserved hypothetical protein) Cluster644 1 1 1 1 1 1 1 ROD_46831(putative phospholipid-binding protein) ENC_33880(Predicted periplasmic or secreted lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.546(Osmotically-inducible protein Y precursor,outer membrane lipoprotein,Predicted periplasmic or secreted lipoprotein,BON domain) b3150(OM lipoprotein) BN373_42101(phospholipid-binding domain protein) t3187(possible lipoprotein) SL1344_3240(possible lipoprotein) Cluster645 1 1 1 1 1 1 1 ROD_46851(conserved hypothetical protein) ENC_33860(conserved hypothetical protein TIGR00252) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.548(hypothetical protein,hypothetical protein,conserved hypothetical protein,Uncharacterised protein family UPF0102) b3148(conserved protein, UPF0102 family) BN373_42081(conserved hypothetical protein TIGR00252) t3185(conserved hypothetical protein) SL1344_3238(conserved hypothetical protein) Cluster646 1 1 1 1 1 1 1 ROD_46861(putative lipoprotein) ENC_33850(Putative lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.549(Lipoprotein activator of PBP from the outer membrane A,Putative lipoprotein,LppC putative lipoprotein) b3147(conserved protein) BN373_42071(putative lipoprotein) t3184(possible exported protein) SL1344_3237(possible exported protein) Cluster647 1 1 1 1 1 1 1 ROD_46871(conserved hypothetical protein) ENC_33840(conserved hypothetical protein TIGR00096) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.550(Ribosomal RNA small subunit methyltransferase I,SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase,Uroporphyrinogen-III synthase,putative S-adenosylmethionine-dependent methyltransferase, YraL family,Tetrapyrrole (Corrin/Porphyrin) Methylases) b3146(16S rRNA C1402 ribose 2'-O-methyltransferase, SAM-dependent) BN373_42061(tetrapyrrole methylase family protein) t3183(conserved hypothetical protein) SL1344_3236(conserved hypothetical protein) Cluster648 1 1 1 1 1 1 1 ROD_47521(D-galactarate dehydratase) ENC_33730(galactarate dehydratase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.566(D-galactarate dehydratase,galactarate dehydratase,D-galactarate dehydratase / Altronate hydrolase, C terminus) b3128((D)-galactarate dehydrogenase) BN373_42051(galactarate dehydratase) t3170(D-galactarate dehydratase) SL1344_3223(D-galactarate dehydratase) Cluster649 1 1 1 1 1 1 1 ROD_47531(2-dehydro-3-deoxyglucarate aldolase) ENC_33720(5-dehydro-4-deoxy-D-glucarate aldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.568(5-keto-4-deoxy-D-glucarate aldolase,alpha-dehydro-beta-deoxy-D-glucarate aldolase,2-dehydro-3-deoxyglucarate aldolase,HpcH/HpaI aldolase/citrate lyase family) b3126(alpha-dehydro-beta-deoxy-D-glucarate aldolase) BN373_42021(2-dehydro-3-deoxyglucarate aldolase) t3169(5-keto-4-deoxy-D-glucarate aldolase) SL1344_3222(5-keto-4-deoxy-D-glucarate aldolase) Cluster650 1 1 1 1 1 1 1 ROD_47541(2-hydroxy-3-oxopropionate reductase) ENC_33710(2-hydroxy-3-oxopropionate reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.569(2-hydroxy-3-oxopropionate reductase,tartronate semialdehyde reductase,Uncharacterized protein conserved in bacteria,2-hydroxy-3-oxopropionate reductase,NAD binding domain of 6-phosphogluconate dehydrogenase) b3125(tartronate semialdehyde reductase) BN373_42011(2-hydroxy-3-oxopropionate reductase) t3168(2-hydroxy-3-oxopropionate reductase) SL1344_3221(2-hydroxy-3-oxopropionate reductase) Cluster651 1 1 1 1 1 1 1 ROD_47551(glycerate kinase 2) ENC_33700(glycerate 2-kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.570(Glycerate kinase,glycerate kinase I,Sugar diacid utilization regulator,glycerate kinase,Glycerate kinase family) b3124(glycerate kinase I) BN373_42001(glycerate kinase) t3167(conserved hypothetical protein) SL1344_3220(conserved hypothetical protein) Cluster652 1 1 1 1 1 1 1 ROD_47691(LysR-family transcriptional regulator) ENC_33610(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.586(HTH-type transcriptional activator AllS,putative DNA-binding transcriptional regulator,transcriptional regulator, ArgP family,LysR substrate binding domain) b3105(predicted DNA-binding transcriptional regulator) BN373_41951(transcriptional regulator, LysR family) t3155(possible LysR-family transcriptional regulator) SL1344_3207(possible LysR-family transcriptional regulator) Cluster653 1 1 1 1 1 1 1 ROD_47711(putative membrane protein) ENC_33600(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.587(Inner membrane protein yhaH,Predicted membrane protein,Protein of unknown function (DUF805)) b3103(inner membrane protein, DUF805 family) BN373_41941(putative inner membrane protein YhaH) t3154(putative membrane protein) SL1344_3206(putative membrane protein) Cluster654 1 1 1 1 1 1 1 pseudoROD_47721(conserved hypothetical protein (fragment)) ENC_33590(Predicted glutathione S-transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.588(Glutathione S-transferase, C-terminal domain) b3102(predicted S-transferase) BN373_41931(conserved hypothetical protein) t3153(conserved hypothetical protein) SL1344_3205(conserved hypothetical protein) Cluster655 1 1 1 1 1 1 1 ROD_47861(putative membrane protein) ENC_33580(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.589(Inner membrane protein yqjF,DoxX) b3101(predicted quinol oxidase subunit) BN373_41921(putative inner membrane protein YqjF) t3152(putative membrane protein) SL1344_3204(putative membrane protein) Cluster656 1 1 1 1 1 1 1 ROD_47881(putative membrane protein) ENC_33560(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.591(Inner membrane protein yqjE,Predicted membrane protein,Protein of unknown function (DUF1469)) b3099(inner membrane protein, DUF1469 family) BN373_41901(conserved hypothetical protein) t3150(putative membrane protein) SL1344_3202(putative membrane protein) Cluster657 1 1 1 1 1 1 1 ROD_47901(putative exported protein) ENC_33540(Protein of unknown function (DUF1090).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.593(hypothetical protein,Protein of unknown function (DUF1090)) b3097(conserved protein) BN373_41881(conserved hypothetical protein) t3148(putative exported protein) SL1344_3201(putative exported protein) Cluster658 1 1 1 1 1 1 1 ROD_47911(putative exported protein) ENC_33530(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.594(Modulator protein MzrA,EnvZ/OmpR regulon moderator) b3096(modulator of EnvZ/OmpR regulon) BN373_41871(conserved hypothetical protein) t3147(putative exported protein) SL1344_3200(putative exported protein) Cluster659 1 1 1 1 1 1 1 ROD_47921(putative membrane protein) ENC_33520(Uncharacterized membrane-associated protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.595(Inner membrane protein YqjA,hypothetical protein,SNARE associated Golgi protein) b3095(required, with yghB, for membrane integrity; inner membrane protein) BN373_41861(putative membrane protein) t3146(putative membrane protein) SL1344_3199(putative membrane protein) Cluster660 1 1 1 1 1 1 1 ROD_47951(uronate isomerase) ENC_33490(D-glucuronate isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.598(Uronate isomerase,glucuronate isomerase,Glucuronate isomerase,Glucuronate isomerase) b3092(uronate isomerase) BN373_41821(glucuronate isomerase) t3058(uronate/glucuronate isomerase) SL1344_3111(Uronate isomerase) Cluster661 1 1 1 1 1 1 1 ROD_47981(putative transport protein) ENC_33470(Na+/serine symporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.601(Na(+)/serine-threonine symporter,serine/threonine transporter SstT,Sodium:dicarboxylate symporter family) b3089(sodium:serine/threonine symporter) BN373_41791(sodium:serine/threonine symporter) t3145(probable membrane transport protein) SL1344_3198(probable membrane transport protein) Cluster662 1 1 1 1 1 1 1 ROD_47991(putative pH-induced membrane-bound redox modulator) ENC_33460(Membrane protein TerC, possibly involved in tellurium resistance) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.602(Inner membrane protein alx,integral membrane protein, TerC family,Integral membrane protein TerC family) b3088(inner membrane protein, part of terminus) BN373_41781(protein Alx) t3144(possible drug efflux protein) SL1344_3197(possible drug efflux protein) Cluster663 1 1 1 1 1 1 1 ROD_48011(putative oxidoreductase) ENC_33450(Predicted dehydrogenases and related proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.604(1,5-anhydro-D-fructose reductase,putative oxidoreductase,Uncharacterized protein conserved in bacteria,Oxidoreductase family, NAD-binding Rossmann fold) b3087(predicted NAD(P)-binding dehydrogenase) BN373_41771(oxidoreductase, NAD binding) t3143(possible oxidoreductase) SL1344_3196(possible oxidoreductase) Cluster664 1 1 1 1 1 1 1 ROD_48021(conserved hypothetical protein) ENC_33440(Predicted metal-dependent hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.606(Protein of unknown function DUF45) b3085(predicted metal dependent hydrolase) BN373_41761(putative xylan 1,4-beta-xylosidase) t3141(conserved hypothetical protein) SL1344_3194(conserved hypothetical protein) Cluster665 1 1 1 1 1 1 1 ROD_48031(putative ribosomal RNA small subunit methyltransferase D) ENC_33430(16S rRNA m(2)G 1207 methyltransferase /23S rRNA m(2)G-1835 methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.607(Ribosomal RNA large subunit methyltransferase G,SAM-dependent 23S ribosomal RNA mG1835 methyltransferase,16S RNA G1207 methylase RsmC,protein-(glutamine-N5) methyltransferase, release factor-specific,Methyltransferase small domain) b3084(23S rRNA mG1835 methyltransferase, SAM-dependent) BN373_41731(methyltransferase family protein) t3140(conserved hypothetical protein) SL1344_3193(conserved hypothetical protein) Cluster666 1 1 1 1 1 1 1 ROD_48051(putrescine aminotransferase) ENC_33220(Ornithine/acetylornithine aminotransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.620(Putrescine aminotransferase,putrescine--2-oxoglutarate aminotransferase,Ornithine/acetylornithine aminotransferase,putrescine aminotransferase,Aminotransferase class-III) b3073(putrescine:2-oxoglutaric acid aminotransferase, PLP-dependent) BN373_41551(putrescine aminotransferase) t3138(probable aminotransferase) SL1344_3191(probable aminotransferase) Cluster667 1 1 1 1 1 1 1 ROD_48081(putative transcriptional Regulator) ENC_33190(transcriptional regulator, PadR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.622(Transcriptional regulator YqjI,lineage-specific thermal regulator protein,transcriptional regulator, Acidobacterial, PadR-family,Transcriptional regulator PadR-like family) b3071(predicted transcriptional regulator, PadR family) BN373_41541(transcriptional regulator, PadR family) t3135(conserved hypothetical protein) SL1344_3188(conserved hypothetical protein) Cluster668 1 1 1 1 1 1 1 ROD_48101(putative siderophore-interacting protein) ENC_33180(Siderophore-interacting protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.623(NADPH-dependent ferric-chelate reductase,Siderophore-interacting FAD-binding domain) b3070(predicted siderophore interacting protein) BN373_41531(siderophore-interacting protein) t3134(conserved hypothetical protein) SL1344_3187(conserved hypothetical protein) Cluster669 0 1 1 2 1 1 1 ENC_22110(Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1347(Positive transcription regulator evgA,DNA-binding transcriptional activator EvgA,Response regulator,sporulation transcription factor Spo0A,Response regulator receiver domain) b0535(predicted DNA-binding transcriptional regulator),b2369(DNA-binding response regulator in two-component regulatory system with EvgS) BN373_41331(positive transcription regulator EvgA) t2314(probable transcriptional regulator) SL1344_0542(probable transcriptional regulator (FimXZ protein)) Cluster670 1 1 1 1 1 1 1 ROD_36191(RNA polymerase sigma-70 factor) ENC_33120(RNA polymerase, sigma 70 subunit, RpoD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.626(Sigma-70,RNA polymerase sigma factor RpoD,RNA polymerase sigma factor RpoD,Sigma-70, non-essential region) b3067(RNA polymerase, sigma 70 (sigma D) factor) BN373_41291(RNA polymerase sigma factor RpoD) t3131(RNA polymerase sigma-70 factor) SL1344_3185(RNA polymerase sigma-70 factor) Cluster671 1 1 1 1 1 1 1 ROD_36171(30S ribosomal subunit protein S21) ENC_33100(SSU ribosomal protein S21P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.628(30S ribosomal protein S21,30S ribosomal protein S21,ribosomal protein S21,Ribosomal protein S21) b3065(30S ribosomal subunit protein S21) BN373_41271(ribosomal protein S21) t3129(30S ribosomal subunit protein S21) SL1344_3183(30S ribosomal subunit protein S21) Cluster672 1 1 1 1 1 1 1 ROD_36161(probable O-sialoglycoprotein endopeptidase (glycoprotease)) ENC_33090(O-sialoglycoprotein endopeptidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.629(t(6)A37 threonylcarbamoyladenosine biosynthesis protein,UGMP family protein,Transcription initiation factor TFIID, subunit TAF12 (also component of histone acetyltransferase SAGA),putative glycoprotease GCP,Glycoprotease family) b3064(t(6)A tRNA modification protein; glycation-binding protein; genome maintenance protein) BN373_41261(O-sialoglycoprotein endopeptidase) t3128(possible glycoprotease) SL1344_3182(possible glycoprotease) Cluster673 1 1 1 1 1 1 1 ROD_36041(putative membrane protein) ENC_32990(acyl-phosphate glycerol-3-phosphate acyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.634(G3P acyltransferase,putative glycerol-3-phosphate acyltransferase PlsY,Predicted membrane protein,acyl-phosphate glycerol 3-phosphate acyltransferase,Domain of unknown function (DUF205)) b3059(probable glycerol-3-phosphate acyltransferase) BN373_41161(conserved hypothetical protein TIGR00023) t3127(putative membrane protein) SL1344_3180(putative membrane protein) Cluster674 1 1 1 1 1 1 1 ROD_36031(dihydroneopterin aldolase) ENC_32980(dihydroneopterin aldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.635(Dihydroneopterin aldolase,bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase,FolB domain,Dihydroneopterin aldolase) b3058(bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase) BN373_41151(dihydroneopterin aldolase) t3126(dihydroneopterin aldolase) SL1344_3179(dihydroneopterin aldolase) Cluster675 1 1 1 1 1 1 1 ROD_36021(undecaprenyl-diphosphatase (bacitracin resistance protein)) ENC_32970(undecaprenyl-diphosphatase UppP) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.636(Undecaprenyl-diphosphatase,undecaprenyl pyrophosphate phosphatase,undecaprenyl-diphosphatase UppP,Bacitracin resistance protein BacA) b3057(undecaprenyl pyrophosphate phosphatase) BN373_41141(undecaprenyl-diphosphatase) t3125(bacitracin resistance protein) SL1344_3178(bacitracin resistance protein (putative undecaprenol kinase)) Cluster676 1 1 1 1 1 1 1 ROD_35991(putative exported protein) ENC_32950(SH3 domain protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.638(SH3 domain-containing protein,Uncharacterized protein with a bacterial SH3 domain homologue,SH3 domain protein) b3055(SH3 domain protein) BN373_41121(SH3 domain protein) t3123(putative membrane protein) SL1344_3176(putative membrane protein) Cluster677 1 1 1 1 1 1 1 ROD_35961(glutamate-ammonia-ligase adenylyltransferase) ENC_32910(Glutamine synthetase adenylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.640(Glutamate-ammonia-ligase adenylyltransferase,bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase,Glutamate-ammonia ligase adenylyltransferase) b3053(fused deadenylyltransferase/adenylyltransferase for glutamine synthetase) BN373_41101(glutamate-ammonia ligase adenylyltransferase) t3121(adenyl-transferase) SL1344_3174(adenyl-transferase) Cluster678 1 1 1 1 1 1 1 ROD_35951(bifunctional protein HldE [includes: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 1-phosphate adenosyltransferase]) ENC_32900(D-alpha,beta-D-heptose 7-phosphate 1-kinase /D-beta-D-heptose 1-phosphate adenylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.641(Bifunctional protein hldE,bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase,ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase,bifunctional protein RfaE, domain I,pfkB family carbohydrate kinase) b3052(fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase) BN373_41091(bifunctional protein HldE) t3120(ADP-heptose synthase) SL1344_3173(ADP-heptose synthase) Cluster679 1 1 1 1 1 1 1 ROD_35921(glycogen synthesis protein GlgS) ENC_13410(Glycogen synthesis protein.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.645(Glycogen synthesis protein glgS,glycogen synthesis protein GlgS,Glycogen synthesis protein) b3049(predicted glycogen synthesis protein) BN373_41081(glycogen synthesis protein GlgS) t3117(glycogen synthesis protein GlgS) SL1344_3170(glycogen synthesis protein GlgS) Cluster680 1 1 1 1 1 1 1 ROD_35911(conserved hypothetical protein) ENC_32890(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.646(hypothetical protein,Uncharacterized protein conserved in bacteria,Membrane fusogenic activity) b3042(conserved protein) BN373_41071(conserved hypothetical protein) t3116(conserved hypothetical protein) SL1344_3169(conserved hypothetical protein) Cluster681 1 1 1 1 1 1 1 ROD_35901(3,4-dihydroxy-2-butanone 4-phosphate synthase) ENC_32880(3,4-dihydroxy-2-butanone 4-phosphate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.648(3,4-dihydroxy-2-butanone 4-phosphate synthase,3,4-dihydroxy-2-butanone 4-phosphate synthase,3,4-dihydroxy-2-butanone-4-phosphate synthase,3,4-dihydroxy-2-butanone 4-phosphate synthase) b3041(3,4-dihydroxy-2-butanone-4-phosphate synthase) BN373_41061(3,4-dihydroxy-2-butanone 4-phosphate synthase) t3115(3,4-dihydroxy-2-butanone 4-phosphate synthase) SL1344_3168(3,4-dihydroxy-2-butanone 4-phosphate synthase) Cluster682 1 1 1 1 1 1 1 ROD_35861(zinc transporter) ENC_32830(Predicted divalent heavy-metal cations transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.654(Zinc transporter ZupT,zinc transporter ZupT,ZIP Zinc transporter) b3040(zinc transporter) BN373_41051(zinc transporter ZupT) t3111(putative membrane protein) SL1344_3164(putative membrane protein) Cluster683 1 1 1 1 1 1 1 ROD_35851(putative aromatic ring-opening dioxygenase) ENC_32820(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.655(hypothetical protein,LigB family dioxygenase,Catalytic LigB subunit of aromatic ring-opening dioxygenase) b3039(predicted dioxygenase, LigB family) BN373_41041(aromatic ring-opening dioxygenase) t3110(conserved hypothetical protein) SL1344_3163(conserved hypothetical protein) Cluster684 1 1 1 1 1 1 1 ROD_35831(putative lipoprotein) ENC_32800(Predicted integral membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.660(hypothetical protein,Protein of unknown function (DUF1190)) b3037(conserved protein, UPF0441 family) BN373_41021(conserved hypothetical protein) t3108(possible lipoprotein) SL1344_3161(possible lipoprotein) Cluster685 1 1 1 1 1 1 1 ROD_35821(outer membrane protein TolC) ENC_32790(type I secretion outer membrane protein, TolC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.661(Outer membrane protein tolC precursor,outer membrane channel protein,type I secretion outer membrane protein, TolC family,Outer membrane efflux protein) b3035(transport channel) BN373_41011(outer membrane protein TolC) t3107(outer membrane protein TolC precursor) SL1344_3160(outer membrane protein TolC precursor) Cluster686 1 1 1 1 1 1 1 ROD_35811(ADP-ribose pyrophosphatase) ENC_32780(nudix hydrolase, YffH family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.662(ADP-ribose pyrophosphatase,ADP-ribose pyrophosphatase NudF,NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding,nudix-type nucleoside diphosphatase, YffH/AdpP family,NUDIX domain) b3034(ADP-ribose pyrophosphatase) BN373_41001(hydrolase, NUDIX family) t3106(conserved hypothetical protein) SL1344_3159(conserved hypothetical protein) Cluster687 1 1 1 1 1 1 1 ROD_35801(conserved hypothetical protein) ENC_32770(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.663(putative dehydrogenase,Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF1249)) b3033(DUF1249 protein YqiB) BN373_40991(conserved hypothetical protein) t3105(conserved hypothetical protein) SL1344_3158(conserved hypothetical protein) Cluster688 1 1 1 1 1 1 1 ROD_35781(conserved hypothetical protein) ENC_32750(Predicted esterase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.665(esterase YqiA,Predicted esterase,Uncharacterised protein family (UPF0227)) b3031(acyl CoA esterase in vitro) BN373_40971(esterase YqiA) t3103(conserved hypothetical protein) SL1344_3156(conserved hypothetical protein) Cluster689 1 1 1 1 1 1 1 ROD_35701(putative monooxygenase) ENC_32600(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.673(Probable quinol monooxygenase ygiN,Antibiotic biosynthesis monooxygenase) b3029(quinol monooxygenase) BN373_40951(quinol monooxygenase YgiN) t3101(conserved hypothetical protein) SL1344_3154(conserved hypothetical protein) Cluster690 1 1 1 1 1 1 1 ROD_35681(two-component system sensor kinase) ENC_32580(Signal transduction histidine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.678(Sensor protein qseC,sensor protein QseC,Signal transduction histidine kinase regulating C4-dicarboxylate transport system,heavy metal sensor kinase,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b3026(quorum sensing sensory histidine kinase in two-component regulatory system with QseB) BN373_40931(sensor protein QseC) t3099(probable two-component system sensor histidine kinase) SL1344_3152(probable two-component system sensor histidine kinase) Cluster691 1 1 1 1 1 1 1 ROD_35671(two-component system response regulator) ENC_32570(Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.679(Transcriptional regulatory protein BasR,DNA-binding transcriptional regulator QseB,Response regulator of citrate/malate metabolism,heavy metal response regulator,Transcriptional regulatory protein, C terminal) b3025(quorum sensing DNA-binding response regulator in two-component regulatory system with QseC) BN373_40921(transcriptional regulatory protein QseB) t3098(probable two-component system response regulator) SL1344_3151(probable two-component system response regulator) Cluster692 1 1 1 1 1 1 1 ROD_35661(possible exported protein) ENC_32560(conserved hypothetical protein TIGR00156) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.680(hypothetical protein,hypothetical protein,Uncharacterized conserved protein,conserved hypothetical protein,Bacterial OB fold (BOF) protein) b3024(conserved protein) BN373_40911(conserved hypothetical protein TIGR00156) t3097(possible exported protein) SL1344_3150(possible exported protein) Cluster693 1 1 1 1 1 1 1 ROD_35651(topoisomerase IV subunit A) ENC_32540(DNA topoisomerase IV subunit A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.683(DNA topoisomerase 4 subunit A,DNA topoisomerase IV subunit A,Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit,DNA topoisomerase IV, A subunit,DNA gyrase/topoisomerase IV, subunit A) b3019(DNA topoisomerase IV, subunit A) BN373_40891(DNA topoisomerase IV, A subunit) t3095(topoisomerase IV subunit A) SL1344_3148(topoisomerase IV subunit A) Cluster694 1 1 1 1 1 1 1 ROD_35641(1-acyl-glycerol-3-phosphate acyltransferase) ENC_32530(1-acyl-sn-glycerol-3-phosphate acyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.684(1-acyl-sn-glycerol-3-phosphate acyltransferase,1-acyl-sn-glycerol-3-phosphate acyltransferase,1-acylglycerol-3-phosphate O-acyltransferases,Acyltransferase) b3018(1-acyl-sn-glycerol-3-phosphate acyltransferase) BN373_40881(1-acyl-sn-glycerol-3-phosphate acyltransferase) t3094(1-acyl-glycerol-3-phosphate acyltransferase) SL1344_3147(1-acyl-glycerol-3-phosphate acyltransferase) Cluster695 1 1 1 1 1 1 1 ROD_35631(SufI protein) ENC_32520(cell division protein SufI) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.685(Cell division protein FtsP precursor,FtsI repressor,copper-resistance protein, CopA family,Multicopper oxidase) b3017(septal ring component that protects the divisome from stress; multicopy suppressor of ftsI(Ts)) BN373_40871(protein SufI) t3093(SufI protein) SL1344_3146(SufI protein) Cluster696 1 1 1 1 1 1 1 ROD_35621(radical SAM superfamily protein) ENC_32510(Fe-S oxidoreductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.693(hypothetical protein,uncharacterized radical SAM protein YgiQ,Radical SAM N-terminal) b4469(conserved protein) BN373_40861(radical SAM domain protein) t3088(conserved hypothetical protein) SL1344_3142(conserved hypothetical protein) Cluster697 1 1 1 1 1 1 1 pseudoROD_35581(AraC-family transcriptional regulator (pseudogene)) ENC_32480(transcriptional regulator, AraC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.698(Uncharacterized HTH-type transcriptional regulator ypdC,transcriptional activator FtrA,DNA gyrase inhibitor,YSIRK-targeted surface antigen transcriptional regulator,AraC-type transcriptional regulator N-terminus) b3010(transcriptional activator of yqhD) BN373_40821(transcriptional regulator, AraC family) t3083(probable AraC-family trancriptional regulatory protein) SL1344_3137(probable AraC-family trancriptional regulatory protein) Cluster698 1 1 1 1 1 1 1 ROD_35571(putative membrane protein) ENC_32470(Uncharacterized membrane-associated protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.699(Inner membrane protein YghB,hypothetical protein,SNARE associated Golgi protein) b3009(required, with yqjA, for membrane integrity; inner membrane protein) BN373_40811(putative membrane protein) t3082(DedA-family integral membrane protein) SL1344_3136(DedA-family integral membrane protein) Cluster699 1 1 1 1 1 1 1 ROD_35551(biopolymer transport protein) ENC_32450(outer membrane transport energization protein ExbB (TC 2.C.1.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.701(Biopolymer transport protein exbB,biopolymer transport protein ExbB,Uncharacterized conserved protein,tonB-system energizer ExbB,MotA/TolQ/ExbB proton channel family) b3006(membrane spanning protein in TonB-ExbB-ExbD complex) BN373_40791(TonB-system energizer ExbB) t3079(biopolymer transport ExbB protein) SL1344_3133(biopolymer transport ExbB protein) Cluster700 1 1 1 1 1 1 1 ROD_35541(biopolymer transport protein) ENC_32440(outer membrane transport energization protein ExbD (TC 2.C.1.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.702(Biopolymer transport protein exbD,biopolymer transport protein ExbD,TonB system transport protein ExbD,Biopolymer transport protein ExbD/TolR) b3005(membrane spanning protein in TonB-ExbB-ExbD complex) BN373_40781(TonB system transport protein ExbD) t3078(biopolymer transport ExbD protein) SL1344_3132(biopolymer transport ExbD protein) Cluster701 1 1 1 1 1 1 1 ROD_35491(putative membrane protein) ENC_32400(conserved hypothetical transmembrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.704(hypothetical protein,Predicted membrane protein,conserved hypothetical protein,Uncharacterized protein family, UPF0114) b3002(predicted inner membrane protein, UPF0114 family) BN373_40771(putative membrane protein) t3074(putative membrane protein) SL1344_3127(putative membrane protein) Cluster702 1 1 1 1 1 1 1 pseudoROD_35381(putative glutathione S-transferase (pseudogene)) ENC_32360(Glutathione S-transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.716(Uncharacterized GST-like protein yghU,putative S-transferase,maleylacetoacetate isomerase,Glutathione S-transferase, C-terminal domain) b2989(predicted S-transferase) BN373_40741(glutathione S-transferase domain protein) t3061(possible transferase) SL1344_3114(possible transferase) Cluster703 1 1 1 1 1 1 1 ROD_35371(bifunctional glutathionylspermidine synthetase/amidase [includes glutathionylspermidine synthase; glutathionylspermidine amidase]) ENC_32350(Glutathionylspermidine synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.717(Bifunctional glutathionylspermidine synthetase/amidase,bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase,Glutathionylspermidine synthase) b2988(fused glutathionylspermidine amidase/glutathionylspermidine synthetase) BN373_40721(bifunctional glutathionylspermidine synthetase/amidase) t3060(glutathionylspermidine synthetase/amidase) SL1344_3113(glutathionylspermidine synthetase/amidase) Cluster704 1 1 1 1 1 1 1 ROD_50211(putative membrane protein) ENC_32260(Uncharacterized membrane protein, possible Na+ channel or pump) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.783(Protein of unknown function (DUF554)) b2966(predicted inner membrane protein, DUF554 family) BN373_40541(putative membrane protein) t3028(putative membrane protein) SL1344_3090(putative membrane protein) Cluster705 1 1 1 1 1 1 1 ROD_50231(nucleoside permease) ENC_32140(nucleoside transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.785(Nucleoside-transport system protein nupG,nucleoside transporter,Nucleoside H+ symporter) b2964(nucleoside transporter) BN373_40521(nucleoside permease NupG) t3026(nucleoside permease) SL1344_3088(nucleoside permease nupg (nucleoside-transport system protein)) Cluster706 1 1 1 1 1 1 1 ROD_50241(membrane-bound lytic murein transglycosylase C) ENC_32130(Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.786(Endo-type membrane-bound lytic murein transglycosylase A precursor,murein transglycosylase C,Domain of unknown function (DUF3393)) b2963(membrane-bound lytic murein transglycosylase C) BN373_40511(membrane-bound lytic murein transglycosylase C) t3025(membrane-bound lytic murein transglycosylase C) SL1344_3087(membrane-bound lytic murein transglycosylase C) Cluster707 1 1 1 1 1 1 1 ROD_50251(probable Fe(2+)-trafficking protein) ENC_32120(Fe-S cluster protector protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.787(Probable Fe(2+)-trafficking protein,oxidative damage protection protein,Fe-S cluster protector protein,Bacterial Fe(2+) trafficking) b2962(protein that protects iron-sulfur proteins against oxidative damage) BN373_40501(protein YggX) t3024(conserved hypothetical protein) SL1344_3086(conserved hypothetical protein) Cluster708 1 1 1 1 1 1 1 ROD_50271(tRNA (guanine-N(7)-)-methyltransferase) ENC_32090(tRNA (guanine-N(7)-)-methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.789(tRNA (guanine-N(7)-)-methyltransferase,tRNA (guanine-N(7)-)-methyltransferase,tRNA (guanine-N(7)-)-methyltransferase,Putative methyltransferase) b2960(tRNA m(7)G46 methyltransferase, SAM-dependent) BN373_40481(tRNA (guanine-N(7)-)-methyltransferase) t3022(conserved hypothetical protein) SL1344_3084(conserved hypothetical protein) Cluster709 1 1 1 1 1 1 1 ROD_50281(conserved hypothetical protein) ENC_32080(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.790(hypothetical protein,hypothetical protein,Uncharacterized protein conserved in bacteria,Protein with unknown function (DUF469)) b2959(conserved protein, DUF469 family) BN373_40471(conserved hypothetical protein) t3021(conserved hypothetical protein) SL1344_3083(conserved hypothetical protein) Cluster710 1 1 1 1 1 1 1 ROD_50291(putative exported protein) ENC_32070(Protein of unknown function (DUF2884).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.791(hypothetical protein,Protein of unknown function (DUF2884)) b2958(predicted protein) BN373_40461(conserved hypothetical protein) t3020(conserved hypothetical protein) SL1344_3082(conserved hypothetical protein) Cluster711 1 1 1 1 1 1 1 ROD_50311(putative oxygen-independent coproporphyrinogen III oxidase) ENC_32050(coproporphyrinogen III oxidase, anaerobic) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.797(Oxygen-independent coproporphyrinogen-III oxidase,HemN family oxidoreductase,Putative heme iron utilization protein,putative oxygen-independent coproporphyrinogen III oxidase,HemN C-terminal region) b2955(predicted oxidoreductase, HemN family) BN373_40421(putative oxygen-independent coproporphyrinogen III oxidase) t3016(possible oxygen-independent coproporphyrinogen III oxidase) SL1344_3079(possible oxygen-independent coproporphyrinogen III oxidase) Cluster712 1 1 1 1 1 1 1 ROD_50321(conserved hypothetical protein) ENC_32040(non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.798(dITP/XTP pyrophosphatase,dITP/XTP pyrophosphatase,Xanthosine triphosphate pyrophosphatase,non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family,Ham1 family) b2954(dITP/XTP pyrophosphatase) BN373_40411(non-canonical purine NTP pyrophosphatase RdgB) t3015(conserved hypothetical protein) SL1344_3078(HAM1 protein homolog) Cluster713 1 1 1 1 1 1 1 ROD_50331(conserved hypothetical protein) ENC_32030(conserved hypothetical protein TIGR00251) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.799(hypothetical protein,hypothetical protein,conserved hypothetical protein,Uncharacterised ACR, YggU family COG1872) b2953(conserved protein, UPF0235 family) BN373_40401(conserved hypothetical protein TIGR00251) t3014(conserved hypothetical protein) SL1344_3077(conserved hypothetical protein) Cluster714 1 1 1 1 1 1 1 ROD_50341(putative membrane protein) ENC_32020(Predicted integral membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.800(YGGT family) b2952(predicted inner membrane protein) BN373_40391(YGGT family protein) t3013(putative membrane protein) SL1344_3076(putative membrane protein) Cluster715 1 1 1 1 1 1 1 ROD_50351(putative amino acid racemase) ENC_32010(pyridoxal phosphate enzyme, YggS family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.801(hypothetical protein,Predicted enzyme with a TIM-barrel fold,pyridoxal phosphate enzyme, YggS family,Alanine racemase, N-terminal domain) b2951(predicted enzyme, binds pyridoxal 5'-phosphate) BN373_40381(alanine racemase family) t3012(conserved hypothetical protein) SL1344_3075(conserved hypothetical protein) Cluster716 1 1 1 1 1 1 1 ROD_50361(putative type II secretion system, ATP-binding, protein) ENC_32000(pilus retraction protein PilT) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.802(hypothetical protein,hypothetical protein,Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB,twitching motility protein,Type II/IV secretion system protein) b2950(predicted pilus retraction ATPase) BN373_40371(twitching motility family protein) t3011(Type II secretion, ATP-binding, protein) SL1344_3074(Type II secretion, ATP-binding, protein) Cluster717 1 1 1 1 1 1 1 ROD_50371(putative holliday junction resolvase) ENC_31990(conserved hypothetical protein TIGR00250) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.803(Putative Holliday junction resolvase,Holliday junction resolvase-like protein,RNAse H domain protein, YqgF family,Uncharacterised protein family (UPF0081)) b2949(predicted Holliday junction resolvase) BN373_40351(conserved hypothetical protein TIGR00250) t3009(conserved hypothetical protein) SL1344_3072(Putative Holliday junction resolvase) Cluster718 1 1 1 1 1 1 1 ROD_50381(conserved hypothetical protein) ENC_31980(Putative transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.804(hypothetical protein,hypothetical protein,Uncharacterized ACR, COG1678) b2948(predicted protein) BN373_40341(conserved hypothetical protein) t3008(conserved hypothetical protein) SL1344_3071(conserved hypothetical protein) Cluster719 1 1 1 1 1 1 1 ROD_50391(glutathione synthetase) ENC_31970(glutathione synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.805(Glutathione synthetase,glutathione synthetase,Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase),glutathione synthase,Prokaryotic glutathione synthetase, ATP-grasp domain) b2947(glutathione synthetase) BN373_40331(glutathione synthase) t3007(glutathione synthetase) SL1344_3070(Glutathione synthetase) Cluster720 1 1 1 1 1 1 1 ROD_50401(conserved hypothetical protein) ENC_31960(16S rRNA m(3)U-1498 methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.806(Ribosomal RNA small subunit methyltransferase E,16S ribosomal RNA methyltransferase RsmE,RNA methyltransferase, RsmE family,RNA methyltransferase) b2946(16S rRNA m(3)U1498 methyltransferase, SAM-dependent) BN373_40321(ribosomal RNA small subunit methyltransferase RsmE) t3006(conserved hypothetical protein) SL1344_3069(conserved hypothetical protein) Cluster721 1 1 1 1 1 1 1 ROD_50411(endonuclease I) ENC_31950(Endonuclease I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.807(Endonuclease-1 precursor,DNA-specific endonuclease I,Endonuclease I) b2945(DNA-specific endonuclease I) BN373_40311(endonuclease-1) t3005(endonuclease I) SL1344_3068(endonuclease I) Cluster722 1 1 1 1 1 1 1 ROD_50421(putative peptidase) ENC_31940(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.808(hypothetical protein,SprT-like family) b2944(conserved protein) BN373_40301(protein SprT) t3004(conserved hypothetical protein) SL1344_3067(conserved hypothetical protein) Cluster723 1 1 1 1 1 1 1 ROD_50471(S-adenosylmethionine synthetase) ENC_31920(S-adenosylmethionine synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.810(S-adenosylmethionine synthase,S-adenosylmethionine synthetase,methionine adenosyltransferase,S-adenosylmethionine synthetase, C-terminal domain) b2942(S-adenosylmethionine synthetase) BN373_40281(S-adenosylmethionine synthetase) t3002(S-adenosylmethionine synthetase) SL1344_3065(S-adenosylmethionine synthetase) Cluster724 1 1 1 1 1 1 1 ROD_50481(biosynthetic arginine decarboxylase) ENC_31910(arginine decarboxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.812(Biosynthetic arginine decarboxylase,arginine decarboxylase,Diaminopimelate decarboxylase,arginine decarboxylase,Pyridoxal-dependent decarboxylase, pyridoxal binding domain) b2938(biosynthetic arginine decarboxylase, PLP-binding) BN373_40251(arginine decarboxylase) t2999(biosynthetic arginine decarboxylase) SL1344_3062(Biosynthetic arginine decarboxylase) Cluster725 1 1 1 1 1 1 1 ROD_50491(agmatinase (agmatine ureohydrolase)) ENC_31900(agmatinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.814(Agmatinase,agmatinase,Arginase/agmatinase/formimi onoglutamate hydrolase, arginase family,agmatinase,Arginase family) b2937(agmatinase) BN373_40241(agmatinase) t2998(agmatine ureohydrolase) SL1344_3054(Agmatinase) Cluster726 1 1 1 1 1 1 1 ROD_50661(d-erythrose-4-phosphate dehydrogenase) ENC_31610(erythrose 4-phosphate dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.829(D-erythrose-4-phosphate dehydrogenase,erythrose 4-phosphate dehydrogenase,Transketolase,erythrose-4-phosphate dehydrogenase,Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain) b2927(D-erythrose 4-phosphate dehydrogenase) BN373_40201(D-erythrose-4-phosphate dehydrogenase) t2989(D-erythrose 4-phosphate dehydrogenase) SL1344_3046(D-erythrose 4-phosphate dehydrogenase) Cluster727 1 1 1 1 1 1 1 ROD_50671(phosphoglycerate kinase) ENC_31600(phosphoglycerate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.830(Phosphoglycerate kinase,phosphoglycerate kinase,3-phosphoglycerate kinase,Phosphoglycerate kinase) b2926(phosphoglycerate kinase) BN373_40191(phosphoglycerate kinase) t2988(phosphoglycerate kinase) SL1344_3045(phosphoglycerate kinase) Cluster728 1 1 1 1 1 1 1 ROD_50751(small-conductance mechanosensitive channel) ENC_31570(Small-conductance mechanosensitive channel) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.832(Small-conductance mechanosensitive channel,mechanosensitive channel MscS,Mechanosensitive ion channel) b2924(mechanosensitive channel protein, small conductance) BN373_40171(small-conductance mechanosensitive channel) t2985(putative membrane protein) SL1344_3043(putative membrane protein) Cluster729 1 1 1 1 1 1 1 ROD_50761(arginine exporter) ENC_31560(L-lysine exporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.833(Arginine exporter protein ArgO,arginine exporter protein,L-lysine exporter,LysE type translocator) b2923(arginine transporter) BN373_40161(arginine exporter protein ArgO) t2984(possible membrane transport protein) SL1344_3042(possible membrane transport protein) Cluster730 1 1 1 1 1 1 1 ROD_50771(putative exported protein) ENC_31550(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.834(26 kDa periplasmic immunogenic protein precursor,oxidative stress defense protein,Predicted periplasmic/secreted protein,Protein of unknown function (DUF541)) b2922(oxidative stress defense protein) BN373_40151(conserved hypothetical protein) t2983(conserved hypothetical protein) SL1344_3041(conserved hypothetical protein) Cluster731 1 1 1 1 1 1 1 ROD_49151(chromosome intitiation inhibitor) ENC_31540(transcriptional regulator, ArgP family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.839(OriC replication inhibitor,chromosome replication initiation inhibitor protein,transcriptional regulator, ArgP family,Bacterial regulatory helix-turn-helix protein, lysR family) b2916(DNA-binding transcriptional activator, replication initiation inhibitor) BN373_40141(transcriptional regulator ArgP) t2982(chromosome intitiation inhibitor) SL1344_3040(chromosome intitiation inhibitor) Cluster732 1 1 1 1 1 1 1 ROD_49161(ribose 5-phosphate isomerase A) ENC_31530(ribose 5-phosphate isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.841(Ribose-5-phosphate isomerase A,ribose-5-phosphate isomerase A,Ribose 5-phosphate isomerase,ribose 5-phosphate isomerase A,Ribose 5-phosphate isomerase A (phosphoriboisomerase A)) b2914(ribose 5-phosphate isomerase, constitutive) BN373_40131(ribose 5-phosphate isomerase A) t2981(ribose 5-phosphate isomerase) SL1344_3039(Ribose-5-phosphate isomerase A) Cluster733 1 1 1 1 1 1 1 ROD_49181(D-3-phosphoglycerate dehydrogenase) ENC_31520(D-3-phosphoglycerate dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.842(D-3-phosphoglycerate dehydrogenase,D-3-phosphoglycerate dehydrogenase,Phosphoserine aminotransferase,phosphoglycerate dehydrogenase,D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain) b2913(D-3-phosphoglycerate dehydrogenase) BN373_40121(phosphoglycerate dehydrogenase) t2980(D-3-phosphoglycerate dehydrogenase) SL1344_3038(D-3-phosphoglycerate dehydrogenase) Cluster734 1 1 1 1 1 1 1 ROD_49221(conserved hypothetical protein) ENC_31510(5-formyltetrahydrofolate cyclo-ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.844(hypothetical protein,5-formyltetrahydrofolate cyclo-ligase family protein,5-formyltetrahydrofolate cyclo-ligase,5-formyltetrahydrofolate cyclo-ligase family) b2912(conserved protein, 5-formyltetrahydrofolate cyclo-ligase family) BN373_40111(5,10-methenyltetrahydrofolate synthetase) t2979(conserved hypothetical protein) SL1344_3037(conserved hypothetical protein) Cluster735 1 1 1 1 1 1 1 ROD_49231(conserved hypothetical protein) ENC_31500(cell division protein ZapA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.846(Z ring-associated protein ZapA,Z-ring-associated protein,Uncharacterized protein conserved in bacteria,Cell division protein ZapA) b2910(FtsZ-associated protein) BN373_40101(Zapa family protein) t2978(conserved hypothetical protein) SL1344_3036(conserved hypothetical protein) Cluster736 1 1 1 1 1 1 1 ROD_49241(conserved hypothetical protein) ENC_31490(yecA family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.847(hypothetical protein,hypothetical protein,Uncharacterized protein conserved in bacteria,yecA family protein,Uncharacterised protein family (UPF0149)) b2909(conserved protein, UPF0149 family) BN373_40091(YecA family protein) t2977(conserved hypothetical protein) SL1344_3035(conserved hypothetical protein) Cluster737 1 1 1 1 1 1 1 ROD_49251(proline aminopeptidase II) ENC_31480(aminopeptidase P . Metallo peptidase. MEROPS family M24B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.848(Xaa-Pro aminopeptidase,proline aminopeptidase P II,Xaa-Pro aminopeptidase,methionine aminopeptidase, type I,Metallopeptidase family M24) b2908(proline aminopeptidase P II) BN373_40081(Xaa-Pro aminopeptidase) t2976(proline aminopeptidase II) SL1344_3034(proline aminopeptidase II) Cluster738 1 1 1 1 1 1 1 ROD_49261(2-octaprenyl-6-methoxyphenol hydroxylase) ENC_31470(2-octaprenyl-6-methoxyphenol hydroxylase /2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.849(2-octaprenyl-6-methoxyphenol hydroxylase,2-octaprenyl-6-methoxyphenyl hydroxylase,2-polyprenyl-6-methoxyphenol 4-hydroxylase,FAD binding domain) b2907(2-octaprenyl-6-methoxyphenol hydroxylase, FAD/NAD(P)-binding) BN373_40071(2-octaprenyl-6-methoxyphenol hydroxylase) t2975(2-octaprenyl-6-methoxyphenol hydroxylase) SL1344_3033(2-octaprenyl-6-methoxyphenol hydroxylase) Cluster739 1 1 1 1 1 1 1 ROD_49281(aminomethyltransferase (glycine cleavage system protein)) ENC_31450(aminomethyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.851(Aminomethyltransferase,glycine cleavage system aminomethyltransferase T,Glycine cleavage system T protein (aminomethyltransferase),glycine cleavage system T protein,Aminomethyltransferase folate-binding domain) b2905(aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex) BN373_40051(glycine cleavage system T protein) t2973(aminomethyltransferase) SL1344_3031(Aminomethyltransferase) Cluster740 1 1 1 1 1 1 1 ROD_49291(glycine cleavage system H protein) ENC_31440(glycine cleavage system H protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.852(Glycine cleavage system H protein,glycine cleavage system protein H,Glycine cleavage system H protein (lipoate-binding),glycine cleavage system H protein,Glycine cleavage H-protein) b2904(glycine cleavage complex lipoylprotein) BN373_40041(glycine cleavage system H protein) t2972(glycine cleavage system H protein) SL1344_3030(Glycine cleavage system H protein. Probable glycine cleavage system H protein) Cluster741 1 1 1 1 1 1 1 ROD_49301(glycine dehydrogenase [decarboxylating]) ENC_31430(glycine dehydrogenase (decarboxylating) alpha subunit /glycine dehydrogenase (decarboxylating) beta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.853(Glycine dehydrogenase [decarboxylating],glycine dehydrogenase,glycine dehydrogenase,Glycine cleavage system P-protein) b2903(glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex) BN373_40031(glycine dehydrogenase (decarboxylating)) t2971(glycine dehydrogenase) SL1344_3029(Glycine dehydrogenase [decarboxylating]) Cluster742 1 1 1 1 1 1 1 ROD_49341(putative membrane protein) ENC_31350(channel protein, hemolysin III family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.856(hypothetical protein,hemolysin,Predicted membrane protein, hemolysin III homolog,channel protein, hemolysin III family,Haemolysin-III related) b2899(inner membrane protein, hemolysin III family HylIII) BN373_39941(channel protein, hemolysin III family) t2967(putative membrane protein) SL1344_3025(putative membrane protein) Cluster743 1 1 1 1 1 1 1 ROD_49361(conserved hypothetical protein) ENC_31330(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.858(hypothetical protein,hypothetical protein,Flavinator of succinate dehydrogenase) b2897(conserved protein) BN373_39921(TPR repeat protein) t2965(conserved hypothetical protein) SL1344_3023(conserved hypothetical protein) Cluster744 1 1 1 1 1 1 1 ROD_49371(putative membrane protein) ENC_31320(Protein of unknown function (DUF1434).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.859(Protein of unknown function (DUF1434)) b2896(predicted protein) BN373_39911(conserved hypothetical protein) t2964(conserved hypothetical protein) SL1344_3022(conserved hypothetical protein) Cluster745 1 1 1 1 1 1 1 ROD_49381(flavodoxin II) ENC_31310(flavodoxin, long chain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.860(Flavodoxin,flavodoxin FldB,flavodoxin,Flavodoxin) b2895(flavodoxin 2) BN373_39901(flavodoxin) t2963(flavodoxin II) SL1344_3021(flavodoxin II) Cluster746 1 1 1 1 1 1 1 ROD_49401(thiol:disulfide interchange protein) ENC_31290(Protein-disulfide isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.862(Thiol:disulfide interchange protein DsbC precursor,protein disulfide isomerase II DsbC,Protein-disulfide isomerase,Disulfide bond isomerase protein N-terminus) b2893(protein disulfide isomerase II) BN373_39881(thiol:disulfide interchange protein DsbC) t2961(thiol:disulfide interchange protein) SL1344_3019(thiol:disulfide interchange protein) Cluster747 1 1 1 1 1 1 1 ROD_49421(peptide chain release factor 2 (RF-2)) ENC_31260(bacterial peptide chain release factor 2 (bRF-2)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.864(Peptide chain release factor 2,peptide chain release factor 2,peptide chain release factor 2,RF-1 domain) b2891(peptide chain release factor RF-2) BN373_39861(peptide chain release factor 2) t2959(peptide chain release factor 2) SL1344_3017(peptide chain release factor 2 (RF-2)) Cluster748 1 1 1 1 1 1 1 ROD_49441(isopentenyl-diphosphate delta-isomerase) ENC_31230(isopentenyl-diphosphate delta-isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.866(Isopentenyl-diphosphate Delta-isomerase,isopentenyl-diphosphate delta-isomerase,isopentenyl-diphosphate delta-isomerase,NUDIX domain) b2889(isopentenyl diphosphate isomerase) BN373_39841(isopentenyl-diphosphate delta-isomerase) t2957(probable isomerase) SL1344_3015(Isopentenyl-diphosphate delta-isomerase) Cluster749 1 1 1 1 1 1 1 ROD_49451(putative cell wall degradation protein) ENC_31220(Membrane proteins related to metalloendopeptidases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.890(Murein hydrolase activator NlpD precursor,lipoprotein NlpD,Membrane-bound metallopeptidase,Peptidase family M23) b2865(novel lipoprotein, function unknown) BN373_39831(M23 peptidase domain protein) t2956(possible lipoprotein) SL1344_3014(possible lipoprotein) Cluster750 1 1 1 1 1 1 1 ROD_42821(putative signal transduction protein) ENC_27220(FOG: EAL domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.165(Cyclic di-GMP phosphodiesterase YhjH,cyclic-di-GMP phosphodiesterase,Predicted signal transduction protein containing sensor and EAL domains,EAL domain) b3525(cyclic-di-GMP phosphodiesterase, FlhDC-regulated) BN373_39061(conserved hypothetical protein) t3906(conserved hypothetical protein) SL1344_3576(conserved hypothetical protein) Cluster751 1 1 1 1 1 1 1 ROD_28991(probable membrane protein) ENC_30960(Amino acid permeases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.892(Inner membrane transport protein YqeG,threonine/serine transporter TdcC,serine transporter,Tryptophan/tyrosine permease family) b2845(predicted transporter) BN373_39021(serine transporter family protein) t2932(probable amino acid transport protein) SL1344_3000(probable amino acid transport protein) Cluster752 1 1 1 1 1 1 1 ROD_28981(putative thiolase) ENC_30930(acetyl-CoA acetyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.893(Acetyl-CoA acetyltransferase,acetyl-CoA acetyltransferase,Transcription-associated recombination protein,acetyl-CoA C-acetyltransferase,Thiolase, N-terminal domain) b2844(predicted acyltransferase) BN373_38991(acetyl-CoA acetyltransferase) t2929(probable acetyl-CoA acetyltransferase) SL1344_2997(probable acetyl-CoA acetyltransferase) Cluster753 1 1 1 1 1 1 1 ROD_28911(2-keto-3-deoxygluconate oxidoreductase) ENC_28900(Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.895(2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase,2-deoxy-D-gluconate 3-dehydrogenase,Uncharacterized conserved protein,2-deoxy-D-gluconate 3-dehydrogenase,short chain dehydrogenase) b2842(2-deoxy-D-gluconate 3-dehydrogenase) BN373_38961(2-deoxy-D-gluconate 3-dehydrogenase) t2927(2-keto-3-deoxygluconate oxidoreductase) SL1344_2995(2-keto-3-deoxygluconate oxidoreductase) Cluster754 1 1 1 1 1 1 1 ROD_28841(putative Asp/Glu/Hydantoin racemase) ENC_30800(aspartate racemase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.897(hypothetical protein,putative racemase,aspartate racemase,Asp/Glu/Hydantoin racemase) b2840(conserved protein, Asp/Glu_racemase family) BN373_38851(aspartate racemase family protein) t2925(conserved hypothetical protein) SL1344_2993(conserved hypothetical protein) Cluster755 1 1 1 1 1 1 1 ROD_28831(transcriptional activator) ENC_30790(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.898(HTH-type transcriptional activator CmpR,DNA-binding transcriptional regulator LysR,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b2839(DNA-binding transcriptional dual regulator) BN373_38841(transcriptional activator protein LysR) t2924(transcriptional activator protein LysR) SL1344_2992(transcriptional activator protein LysR) Cluster756 1 1 1 1 1 1 1 ROD_28821(diaminopimelate decarboxylase) ENC_30780(diaminopimelate decarboxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.899(Diaminopimelate decarboxylase,diaminopimelate decarboxylase,Diaminopimelate decarboxylase,diaminopimelate decarboxylase,Pyridoxal-dependent decarboxylase, pyridoxal binding domain) b2838(diaminopimelate decarboxylase, PLP-binding) BN373_38831(diaminopimelate decarboxylase) t2923(diaminopimelate decarboxylase) SL1344_2991(diaminopimelate decarboxylase) Cluster757 1 1 1 1 1 1 1 ROD_28811(galactose operon repressor) ENC_30720(transcriptional regulator, LacI family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.900(Galactose operon repressor,DNA-binding transcriptional regulator GalR,ABC-type sugar transport system, periplasmic component,catabolite control protein A,Periplasmic binding proteins and sugar binding domain of LacI family) b2837(DNA-binding transcriptional repressor) BN373_38771(transcriptional regulator GalR) t2921(galactose operon repressor) SL1344_2989(galactose operon repressor) Cluster758 1 1 1 1 1 1 1 ROD_28791(Aas bifunctional protein [includes: 2-acylglycerophosphoethanolamin acyltransferase; acyl [acyl-carrier-protein] synthetase) ENC_30710(Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.903(Bifunctional protein aas,bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase,ABC-type sugar transport system, periplasmic component,amino acid adenylation domain,AMP-binding enzyme) b2836(fused 2-acylglycerophospho-ethanolamine acyl transferase/acyl-acyl carrier protein synthetase) BN373_38751(2-acyl-glycerophospho-ethanolamine acyltransferase/acyl-acyl-carrier protein synthetase) t2919(2-acylglycerophosphoethanolamine acyl transferase) SL1344_2988(2-acylglycerophosphoethanolamine acyl transferase/acyl carrier protein synthetase) Cluster759 1 1 1 1 1 1 1 ROD_28781(major facilitator superfamily protein) ENC_30700(Major Facilitator Superfamily.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.904(Lysophospholipid transporter lplT,lysophospholipid transporter LplT,H+ Antiporter protein,Major Facilitator Superfamily) b2835(lysophospholipid transporter) BN373_38741(lysophospholipid transporter) t2918(putative membrane protein) SL1344_2987(putative membrane protein) Cluster760 1 1 1 1 1 1 1 ROD_28771(putative aldo/keto reductase) ENC_30690(Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.905(hypothetical protein,putative aldo-keto reductase,Predicted oxidoreductase,voltage-dependent potassium channel beta subunit,Aldo/keto reductase family) b2834(predicted oxidoreductase, NADP(H)-dependent aldo-keto reductase; suppresses tyrosine requirement of tyrA14 O6 strain) BN373_38731(NADP(H)-dependent aldo-keto reductase Tas) t2917(possible oxidoreductase) SL1344_2986(possible oxidoreductase) Cluster761 1 1 1 1 1 1 1 ROD_28761(possible lipoprotein) ENC_30680(Bacterial protein of unknown function (DUF903).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.906(Uncharacterized lipoprotein ygdR precursor,Bacterial protein of unknown function (DUF903)) b2833(novel lipoprotein) BN373_38721(putative lipoprotein) t2916(possible lipoprotein) SL1344_2985(possible lipoprotein) Cluster762 1 1 1 1 1 1 1 ROD_28721((di)nucleoside polyphosphate hydrolase) ENC_30660(NUDIX domain.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.910(RNA pyrophosphohydrolase,RNA pyrophosphohydrolase,Predicted NTP pyrophosphohydrolase,mutator mutT protein,NUDIX domain) b2830(RNA pyrophosphohydrolase) BN373_38691((Di)nucleoside polyphosphate hydrolase) t2913(conserved hypothetical protein) SL1344_2982(RNA pyrophosphohydrolase) Cluster763 1 1 1 1 1 1 1 ROD_28711(phosphoenolpyruvate-protein phosphotransferase (PTS system, enzyme I)) ENC_30650(phosphoenolpyruvate-protein phosphotransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.911(Phosphoenolpyruvate-protein phosphotransferase,fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain,Signal transduction protein containing GAF and PtsI domains,phosphoenolpyruvate-protein phosphotransferase,PEP-utilising enzyme, TIM barrel domain) b2829(fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein) BN373_38681(phosphoenolpyruvate-protein phosphotransferase) t2912(phosphoenolpyruvate-protein phosphotransferase) SL1344_2981(phosphoenolpyruvate-protein phosphotransferase) Cluster764 1 1 1 1 1 1 1 ROD_28701(prolipoprotein diacylglyceryl transferase) ENC_30640(prolipoprotein diacylglyceryl transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.912(Prolipoprotein diacylglyceryl transferase,prolipoprotein diacylglyceryl transferase,prolipoprotein diacylglyceryl transferase,Prolipoprotein diacylglyceryl transferase) b2828(phosphatidylglycerol-prolipoprotein diacylglyceryl transferase) BN373_38671(prolipoprotein diacylglyceryl transferase) t2911(prolipoprotein diacylglyceryl transferase) SL1344_2980(Prolipoprotein diacylglyceryl transferase) Cluster765 1 1 1 1 1 1 1 ROD_28691(thymidylate synthase) ENC_30630(thymidylate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.913(Thymidylate synthase,thymidylate synthase,thymidylate synthase,Thymidylate synthase) b2827(thymidylate synthetase) BN373_38661(thymidylate synthase) t2910(thymidylate synthetase) SL1344_2979(Thymidylate synthase) Cluster766 1 1 1 1 1 1 1 ROD_28681(prepilin peptidase-dependent protein A) ENC_30610(prepilin-type N-terminal cleavage/methylation domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.914(hypothetical protein,Tfp pilus assembly protein FimT) b2826(conserved protein) BN373_38651(prepilin peptidase-dependent protein A) t2908(prepilin peptidase dependent protein A precursor) SL1344_2978(prepilin peptidase dependent protein A precursor) Cluster767 1 1 1 1 1 1 1 ROD_28671(prepilin peptidase-dependent protein B) ENC_30600(prepilin-type N-terminal cleavage/methylation domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.915(hypothetical protein,Type II secretory pathway, component PulJ,prepilin-type N-terminal cleavage/methylation domain) b2825(conserved protein) BN373_38641(prepilin peptidase dependent protein B) t2907(prepilin peptidase dependent protein B precursor) SL1344_2977(prepilin peptidase dependent protein B precursor) Cluster768 1 1 1 1 1 1 1 ROD_28661(putative exported protein) ENC_30590(Protein of unknown function (DUF2509).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.916(hypothetical protein,Protein of unknown function (DUF2509)) b2824(conserved protein, DUF2509 family) BN373_38631(conserved hypothetical protein) t2906(conserved hypothetical protein) SL1344_2976(conserved hypothetical protein) Cluster769 1 1 1 1 1 1 1 ROD_28631(protease III precursor (pitrilysin)) ENC_30570(pitrilysin . Metallo peptidase. MEROPS family M16A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.919(Protease 3 precursor,protease3,coenzyme PQQ biosynthesis protein PqqF,Insulinase (Peptidase family M16)) b2821(protease III) BN373_38601(protease III) t2903(protease III precursor) SL1344_2973(protease III precursor (pitrilysin)) Cluster770 1 1 1 1 1 1 1 ROD_28621(exodeoxyribonuclease V beta subunit) ENC_30560(exodeoxyribonuclease V, beta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.920(Exodeoxyribonuclease V beta chain,exonuclease V subunit beta,exodeoxyribonuclease V, beta subunit,UvrD/REP helicase) b2820(exonuclease V (RecBCD complex), beta subunit) BN373_38591(exodeoxyribonuclease V, beta subunit) t2902(exonuclease V subunit) SL1344_2972(exonuclease V subunit) Cluster771 1 1 1 1 1 1 1 ROD_28601(amino-acid acetyltransferase (N-acetylglutamate synthase)) ENC_30530(N-acetylglutamate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.922(Amino-acid acetyltransferase,N-acetylglutamate synthase,Acetylglutamate kinase,amino-acid N-acetyltransferase,Amino acid kinase family) b2818(fused acetylglutamate kinase homolog (inactive)/amino acid N-acetyltransferase) BN373_38561(amino-acid N-acetyltransferase) t2900(N-acetylglutamate synthase) SL1344_2970(Amino-acid acetyltransferase) Cluster772 1 1 1 1 1 1 1 ROD_28591(N-acetylmuramoyl-L-alanine amidase) ENC_30520(N-acetylmuramoyl-L-alanine amidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.923(N-acetylmuramoyl-L-alanine amidase AmiC precursor,N-acetylmuramoyl-l-alanine amidase I,N-acetylmuramoyl-L-alanine amidase CwlD,N-acetylmuramoyl-L-alanine amidase) b2817(N-acetylmuramoyl-L-alanine amidase) BN373_38551(N-acetylmuramoyl-L-alanine amidase AmiC) t2899(N-acetylmuramoyl-L-alanine amidase) SL1344_2969(N-acetylmuramoyl-L-alanine amidase) Cluster773 1 1 1 1 1 1 1 ROD_28581(membrane-bound lytic murein transglycosylase A) ENC_30510(Membrane-bound lytic murein transglycosylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.961(Membrane-bound lytic murein transglycosylase A precursor,murein transglycosylase A,MltA specific insert domain) b2813(membrane-bound lytic murein transglycosylase A) BN373_38111(membrane-bound lytic murein transglycosylase A) t2896(membrane-bound lytic murein transglycosylase A precursor) SL1344_2968(membrane-bound lytic murein transglycosylase A precursor) Cluster774 1 1 1 1 1 1 1 ROD_28571(conserved hypothetical protein) ENC_30500(Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.962(Molybdopterin-synthase adenylyltransferase,sulfur acceptor protein CsdL,thiazole biosynthesis adenylyltransferase ThiF,ThiF family) b2812(sulfur acceptor for CsdA) BN373_38101(ThiF family protein) t2895(conserved hypothetical protein) SL1344_2967(conserved hypothetical protein) Cluster775 1 1 1 1 1 1 1 ROD_28561(putative Fe-S metabolism associated protein) ENC_30490(cysteine desulfurase, sulfur acceptor subunit CsdE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.963(Uncharacterized sufE-like protein ygdK,CsdA-binding activator,cysteine desulfurase, sulfur acceptor subunit CsdE,Fe-S metabolism associated domain) b2811(CsdA-binding activator; Fe-S protein) BN373_38091(cysteine desulfuration protein CsdE) t2893(conserved hypothetical protein) SL1344_2965(conserved hypothetical protein) Cluster776 1 1 1 1 1 1 1 ROD_28551(cysteine sulfinate desulfinase) ENC_30480(cysteine desulfurase, catalytic subunit CsdA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.964(Cysteine sulfinate desulfinase,cysteine sulfinate desulfinase,Kynureninase,cysteine desulfurase, catalytic subunit CsdA,Aminotransferase class-V) b2810(cysteine sulfinate desulfinase) BN373_38081(cysteine desulfurase, catalytic subunit CsdA) t2892(possible aminotransferase) SL1344_2964(possible aminotransferase) Cluster777 1 1 1 1 1 1 1 ROD_28541(putative lipoprotein) ENC_30470(Bacterial protein of unknown function (DUF903).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.965(Uncharacterized lipoprotein ygdR precursor,Bacterial protein of unknown function (DUF903)) b2809(novel lipoprotein) BN373_38071(putative lipoprotein) t2891(possible lipoprotein) SL1344_2963(possible lipoprotein) Cluster778 1 1 1 1 1 1 1 ROD_28521(putative outer membrane protein) ENC_30450(Uncharacterized small membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.968(hypothetical protein,hypothetical protein,Protein of unknown function (DUF423)) b2807(inner membrane protein, UPF0382 family) BN373_38051(putative membrane protein) t2889(conserved hypothetical protein) SL1344_2961(conserved hypothetical protein) Cluster779 1 1 1 1 1 1 1 ROD_28511(putative RNA 2'-O-ribose methyltransferase) ENC_30440(Predicted SAM-dependent methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.969(Ribosomal RNA large subunit methyltransferase M,putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase,FtsJ-like methyltransferase) b2806(23S rRNA C2498 ribose 2'-O-methyltransferase, SAM-dependent) BN373_38041(conserved hypothetical protein) t2888(conserved hypothetical protein) SL1344_2960(conserved hypothetical protein) Cluster780 1 1 1 1 1 1 1 ROD_28501(L-fucose operon activator) ENC_32370(Transcriptional regulators of sugar metabolism) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.970(Glycerol-3-phosphate regulon repressor,DNA-binding transcriptional activator FucR,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,Bacterial regulatory proteins, deoR family) b2805(DNA-binding transcriptional activator) BN373_38031(L-fucose operon activator) t2887(l-fucose operon activator) SL1344_2959(l-fucose operon activator) Cluster781 1 1 1 1 1 1 1 ROD_28471(L-fucose isomerase) ENC_23210(L-fucose isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.973(L-fucose isomerase,L-fucose isomerase,L-fucose isomerase and related proteins,L-fucose isomerase,L-fucose isomerase, first N-terminal domain) b2802(L-fucose isomerase) BN373_38001(L-fucose isomerase) t2884(L-fuculose isomerase) SL1344_2956(L-fuculose isomerase) Cluster782 1 1 1 1 1 1 1 ROD_28411(L-fuculose phosphate aldolase) ENC_23280(L-fuculose 1-phosphate aldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.975(L-fuculose phosphate aldolase,L-fuculose phosphate aldolase,Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases,L-fuculose phosphate aldolase,Class II Aldolase and Adducin N-terminal domain) b2800(L-fuculose-1-phosphate aldolase) BN373_37981(L-fuculose phosphate aldolase) t2882(fuculose-1-phosphate aldolase) SL1344_2954(fuculose-1-phosphate aldolase) Cluster783 1 1 1 1 1 1 1 ROD_28401(Uncharacterised exonuclease xni) ENC_30430(5'-3' exonuclease (including N-terminal domain of PolI)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.977(Exonuclease IX,flap endonuclease-like protein,DNA polymerase I - 3'-5' exonuclease and polymerase domains,DNA polymerase I,5'-3' exonuclease, N-terminal resolvase-like domain) b2798(Ssb-binding protein, misidentified as ExoIX) BN373_37961(exodeoxyribonuclease-9) t2880(5'-3' exonuclease) SL1344_2952(5'-3' exonuclease) Cluster784 1 1 1 1 1 1 1 ROD_28361(serine transporter) ENC_30410(serine transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.979(Serine transporter,threonine/serine transporter TdcC,serine transporter) b2796(predicted serine transporter) BN373_37841(serine transporter) t2878(putative serine transporter) SL1344_2950(putative serine transporter) Cluster785 1 1 1 1 1 1 1 ROD_28351(putative decarboxylase) ENC_30400(Predicted Rossmann fold nucleotide-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.980(LOG family protein ygdH,conserved hypothetical protein,Domain of unknown function (DUF3412)) b2795(conserved protein, UPF0717 family) BN373_37831(conserved hypothetical protein) t2877(conserved hypothetical protein) SL1344_2949(conserved hypothetical protein) Cluster786 1 1 1 1 1 1 1 ROD_28341(NADPH-dependent 7-cyano-7-deazaguanine reductase) ENC_30390(7-cyano-7-deazaguanine reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.981(NADPH-dependent 7-cyano-7-deazaguanine reductase,7-cyano-7-deazaguanine reductase,Uncharacterized protein conserved in bacteria,queuine synthase,GTP cyclohydrolase I) b2794(7-cyano-7-deazaguanine reductase (NADPH-dependent)) BN373_37821(7-cyano-7-deazaguanine reductase) t2876(conserved hypothetical protein) SL1344_2948(conserved hypothetical protein) Cluster787 1 1 1 1 1 1 1 pseudoROD_30221(tRNA pseudouridine synthase C (pseudogene)) ENC_30350(tRNA pseudouridine synthase C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.985(tRNA pseudouridine synthase C,tRNA pseudouridine synthase C,pseudouridine synthase, RluA family,RNA pseudouridylate synthase) b2791(tRNA U65 pseudouridine synthase) BN373_37781(tRNA pseudouridine synthase C) t2873(putative RNA pseudouridylate synthase) SL1344_2945(putative RNA pseudouridylate synthase) Cluster788 1 1 1 1 1 1 1 ROD_30231(conserved hypothetical protein) ENC_30340(Flavodoxins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.986(hypothetical protein,flavodoxin,Nitric oxide synthase, oxygenase domain,sulfite reductase [NADPH] flavoprotein, alpha-component,Flavodoxin) b2790(predicted flavoprotein) BN373_37771(flavodoxin) t2872(conserved hypothetical protein) SL1344_2944(conserved hypothetical protein) Cluster789 1 1 1 1 1 1 1 ROD_30301(two-component sensor kinase/response regulator) ENC_30270(Hpt sensor hybrid histidine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.990(Signal transduction histidine-protein kinase BarA,hybrid sensory histidine kinase BarA,Uncharacterized domain of BarA-like signal transduction histidine kinases,TMAO reductase sytem sensor TorS,Uncharacterized signal transduction histidine kinase domain (DUF2222)) b2786(hybrid sensory histidine kinase, in two-component regulatory system with UvrY) BN373_37721(signal transduction histidine-protein kinase BarA) t2867(sensor protein) SL1344_2939(sensor protein) Cluster790 1 1 1 1 1 1 1 ROD_30311(23s rRNA (uracil-5-)-methyltransferase) ENC_30260(23S rRNA m(5)U-1939 methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.991(23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD,23S rRNA m(5)U1939 methyltransferase,Predicted O-methyltransferase,23S rRNA (uracil-5-)-methyltransferase RumA,tRNA (Uracil-5-)-methyltransferase) b2785(23S rRNA m(5)U1939 methyltransferase, SAM-dependent) BN373_37711(23S rRNA (uracil-5-)-methyltransferase RumA) t2866(putative RNA methyltransferase) SL1344_2938(putative RNA methyltransferase) Cluster791 1 1 1 1 1 1 1 ROD_30331(nucleoside triphosphate pyrophosphohydrolase) ENC_30240(MazG family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.993(Nucleoside triphosphate pyrophosphohydrolase,nucleoside triphosphate pyrophosphohydrolase,MazG family protein,MazG nucleotide pyrophosphohydrolase domain) b2781(nucleoside triphosphate pyrophosphohydrolase) BN373_37691(MazG family protein) t2855(conserved hypothetical protein) SL1344_2933(conserved hypothetical protein) Cluster792 1 1 1 1 1 1 1 ROD_30341(CTP synthetase) ENC_30230(CTP synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.994(CTP synthase,CTP synthetase,Carbamoylphosphate synthase small subunit,CTP synthase,CTP synthase N-terminus) b2780(CTP synthetase) BN373_37681(CTP synthase) t2854(CTP synthetase) SL1344_2932(CTP synthase) Cluster793 1 1 1 1 1 1 1 ROD_30351(enolase) ENC_30220(enolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.995(Enolase,enolase,L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily,phosphopyruvate hydratase,Enolase, C-terminal TIM barrel domain) b2779(enolase) BN373_37671(phosphopyruvate hydratase) t2853(enolase) SL1344_2931(Enolase) Cluster794 1 1 1 1 1 1 1 ROD_30371(conserved hypothetical protein) ENC_30180(Organic radical activating enzymes) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.998(7-carboxy-7-deazaguanine synthase,Predicted membrane protein,7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE,Radical SAM superfamily) b2777(7-carboxy-7-deazaguanine synthase; queosine biosynthesis) BN373_37651(radical SAM domain protein) t2852(conserved hypothetical protein) SL1344_2930(conserved hypothetical protein) Cluster795 1 1 1 1 1 1 1 ROD_30411(putative 6-pyruvoyl tetrahydrobiopterin synthase) ENC_30130(preQ(0) biosynthesis protein QueD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1014(6-carboxy-5,6,7,8-tetrahydropterin synthase,6-pyruvoyl tetrahydropterin synthase/QueD family protein,6-pyruvoyl tetrahydropterin synthase) b2765(6-pyruvoyl tetrahydrobiopterin synthase (PTPS)) BN373_37641(queuosine biosynthesis protein QueD) t2850(putative 6-pyruvoyl tetrahydrobiopterin synthase) SL1344_2928(6-pyruvoyl tetrahydrobiopterin synthase) Cluster796 1 1 1 1 1 1 1 ROD_30421(sulfite reductase (NADPH) flavoprotein alpha subunit) ENC_30120(sulfite reductase (NADPH) alpha subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1015(Sulfite reductase [NADPH] flavoprotein alpha-component,sulfite reductase subunit alpha,Nitric oxide synthase, oxygenase domain,sulfite reductase [NADPH] flavoprotein, alpha-component,FAD binding domain) b2764(sulfite reductase, alpha subunit, flavoprotein) BN373_37631(sulfite reductase [NADPH] flavoprotein, alpha-component) t2849(sulfite reductase (NADPH) flavoprotein beta subunit) SL1344_2927(sulfite reductase (NADPH) flavoprotein beta subunit) Cluster797 1 1 1 1 1 1 1 ROD_30431(sulfite reductase (NADPH) hemoprotein beta subunit) ENC_30110(sulfite reductase (NADPH) beta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1016(Sulfite reductase [NADPH] hemoprotein beta-component,sulfite reductase subunit beta,Sulfite reductase, beta subunit (hemoprotein),sulfite reductase (NADPH) hemoprotein, beta-component,Nitrite and sulphite reductase 4Fe-4S domain) b2763(sulfite reductase, beta subunit, NAD(P)-binding, heme-binding) BN373_37621(sulfite reductase (NADPH) hemoprotein, beta-component) t2848(sulfite reductase (NADPH) hemoprotein alpha subunit) SL1344_2926(sulfite reductase (NADPH) hemoprotein alpha subunit) Cluster798 1 1 1 1 1 1 1 ROD_30441(phosphoadenosine phosphosulfate reductase) ENC_30100(phosphoadenylylsulfate reductase (thioredoxin)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1017(Phosphoadenosine phosphosulfate reductase,phosphoadenosine phosphosulfate reductase,Uncharacterized protein conserved in bacteria,phosphoadenosine phosphosulfate reductase,Phosphoadenosine phosphosulfate reductase family) b2762(3'-phosphoadenosine 5'-phosphosulfate reductase) BN373_37611(phosphoadenosine phosphosulfate reductase) t2847(3'-phosphoadenosine 5'-phosphosulfate sulfotransferase) SL1344_2925(Phosphoadenosine phosphosulfate reductase) Cluster799 1 1 1 1 1 1 1 ROD_30561(alkaline phosphatase isozyme conversion protein) ENC_30090(IAP aminopeptidase. Metallo peptidase. MEROPS family M28C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1020(Arginyl aminopeptidase,alkaline phosphatase isozyme conversion aminopeptidase,Predicted aminopeptidase, Iap family,succinyl-diaminopimelate desuccinylase,Peptidase family M28) b2753(aminopeptidase in alkaline phosphatase isozyme conversion) BN373_37601(alkaline phosphatase isozyme conversion peptidase) t2837(alkaline phosphatase isozyme conversion protein) SL1344_2915(alkaline phosphatase isozyme conversion protein) Cluster800 1 1 1 1 1 1 1 ROD_30571(Sulfate adenylyltransferase subunit 2) ENC_30070(sulfate adenylyltransferase subunit 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1021(Sulfate adenylyltransferase subunit 2,sulfate adenylyltransferase subunit 2,PUA domain (predicted RNA-binding domain),sulfate adenylyltransferase, small subunit,Phosphoadenosine phosphosulfate reductase family) b2752(sulfate adenylyltransferase, subunit 2) BN373_37581(sulfate adenylyltransferase subunit 2) t2836(ATP sulfurylase subunit) SL1344_2914(ATP sulfurylase (ATP:sulfate adenyltransferase)) Cluster801 1 1 1 1 1 1 1 ROD_30581(Sulfate adenylyltransferase subunit 1) ENC_30060(sulfate adenylyltransferase subunit 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1022(Sulfate adenylyltransferase subunit 1,sulfate adenylyltransferase subunit 1,Adenylylsulfate kinase and related kinases,sulfate adenylyltransferase, large subunit,Elongation factor Tu GTP binding domain) b2751(sulfate adenylyltransferase, subunit 1) BN373_37571(sulfate adenylyltransferase subunit 1) t2835(ATP sulfurylase subunit) SL1344_2913(Sulfate adenylyltransferase subunit 1) Cluster802 1 1 1 1 1 1 1 ROD_30591(adenosine 5-phosphosulfate kinase) ENC_30050(adenylylsulfate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1023(Adenylyl-sulfate kinase,adenylylsulfate kinase,Adenylylsulfate kinase and related kinases,adenylylsulfate kinase,Adenylylsulphate kinase) b2750(adenosine 5'-phosphosulfate kinase) BN373_37561(adenylylsulfate kinase) t2834(adenosine 5-phosphosulfate kinase) SL1344_2912(Adenylylsulfate kinase) Cluster803 1 1 1 1 1 1 1 ROD_30601(putative membrane protein) ENC_30040(Protein of unknown function (DUF3561).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1024(Inner membrane protein ygbE,hypothetical protein,Protein of unknown function (DUF3561)) b2749(conserved inner membrane protein) BN373_37551(putative membrane protein) t2833(conserved hypothetical protein) SL1344_2911(conserved hypothetical protein) Cluster804 1 1 1 1 1 1 1 ROD_30611(cell division protein) ENC_30030(cell division protein FtsB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1025(Cell division protein FtsB,cell division protein FtsB,Septum formation initiator) b2748(cell division protein) BN373_37541(cell division protein FtsB) t2832(conserved hypothetical protein) SL1344_2910(Cell division protein ftsB homolog) Cluster805 1 1 1 1 1 1 1 ROD_30621(2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase) ENC_30020(2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1026(2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase,2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase,2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase,2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase,Uncharacterized protein family UPF0007) b2747(4-diphosphocytidyl-2C-methyl-D-erythritol synthase) BN373_37531(2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase) t2831(2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase) SL1344_2909(2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase) Cluster806 1 1 1 1 1 1 1 ROD_30631(2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase) ENC_30010(2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1027(2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase,2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase,2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase,2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase,YgbB family) b2746(2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase) BN373_37521(2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase) t2830(2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase) SL1344_2908(2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase) Cluster807 1 1 1 1 1 1 1 ROD_30641(tRNA pseudouridine synthase D) ENC_30000(conserved hypothetical protein TIGR00094) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1028(tRNA pseudouridine synthase D,tRNA pseudouridine synthase D,tRNA pseudouridine synthase, TruD family,tRNA pseudouridine synthase D (TruD)) b2745(tRNA(Glu) U13 pseudouridine synthase) BN373_37511(tRNA pseudouridine synthase D) t2829(conserved hypothetical protein) SL1344_2907(tRNA pseudouridine synthase D) Cluster808 1 1 1 1 1 1 1 ROD_30661(Protein-L-isoaspartate O-methyltransferase) ENC_29970(protein-L-isoaspartate(D-aspartate) O-methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1030(Protein-L-isoaspartate O-methyltransferase,protein-L-isoaspartate O-methyltransferase,tRNA(1-methyladenosine) methyltransferase and related methyltransferases,protein-L-isoaspartate O-methyltransferase,Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)) b2743(L-isoaspartate protein carboxylmethyltransferase type II) BN373_37491(protein-L-isoaspartate O-methyltransferase) t2827(L-isoaspartyl protein carboxyl methyltransferase type II) SL1344_2905(Protein-L-isoaspartate O-methyltransferase) Cluster809 1 1 1 1 1 1 1 ROD_30671(lipoprotein) ENC_29960(Membrane proteins related to metalloendopeptidases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1031(Murein hydrolase activator NlpD precursor,lipoprotein NlpD,Membrane-bound metallopeptidase,Peptidase family M23) b2742(activator of AmiC murein hydrolase activity, lipoprotein) BN373_37481(lipoprotein NlpD) t2826(lipoprotein NlpD precursor) SL1344_2904(lipoprotein NlpD precursor) Cluster810 1 1 1 1 1 1 1 ROD_30681(RNA polymerase sigma factor (sigma-38)) ENC_29950(RNA polymerase sigma factor RpoS) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1032(RNA polymerase sigma factor rpoS,RNA polymerase sigma factor RpoS,RNA polymerase sigma factor RpoS,Sigma-70 region 2) b2741(RNA polymerase, sigma S (sigma 38) factor) BN373_37471(RNA polymerase sigma factor RpoS) t2825(RNA polymerase sigma subunit RpoS) SL1344_2903(RNA polymerase sigma subunit RpoS (sigma-38)) Cluster811 1 1 1 1 1 1 1 ROD_30741(DNA mismatch repair protein) ENC_29870(DNA mismatch repair protein MutS) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1042(DNA mismatch repair protein mutS,DNA mismatch repair protein MutS,ATP phosphoribosyltransferase,DNA mismatch repair protein MutS,MutS domain V) b2733(methyl-directed mismatch repair protein) BN373_37381(DNA mismatch repair protein MutS) t2810(DNA mismatch repair protein) SL1344_2888(DNA mismatch repair protein) Cluster812 1 1 1 1 1 1 1 ROD_30791(conserved hypothetical protein) ENC_29850(Nitrous oxide-stimulated promoter.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1043(hypothetical protein,Nitrous oxide-stimulated promoter) b2732(predicted protein) BN373_37151(conserved hypothetical protein) t2762(conserved hypothetical protein) SL1344_2840(conserved hypothetical protein) Cluster813 1 1 1 1 1 1 1 ROD_30801(formate hydrogenlyase transcriptional activator) ENC_29840(Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1045(Formate hydrogenlyase transcriptional activator,formate hydrogenlyase transcriptional activator FhlA,Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,Nif-specific regulatory protein,Sigma-54 interaction domain) b2731(DNA-binding transcriptional activator) BN373_37011(formate hydrogenlyase transcriptional activator) t2761(transcriptional activator of the formate hydrogenlyase system) SL1344_2839(transcriptional activator of the formate hydrogenlyase system) Cluster814 1 1 1 1 1 1 1 ROD_30811(hydrogenase isoenzymes formation protein) ENC_29830(hydrogenase expression/formation protein HypE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1046(Hydrogenase isoenzymes formation protein hypE,thiamine monophosphate kinase,Hydrogenase maturation factor,hydrogenase expression/formation protein HypE,AIR synthase related protein, C-terminal domain) b2730(carbamoyl dehydratase, hydrogenases 1,2,3 maturation protein) BN373_37001(hydrogenase expression/formation protein HypE) t2760(hydrogenase isoenzymes formation protein HypE) SL1344_2838(hydrogenase isoenzymes formation protein HypE) Cluster815 1 1 1 1 1 1 1 ROD_30821(hydrogenase isoenzymes formation protein) ENC_29820(hydrogenase expression/formation protein HypD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1047(Hydrogenase isoenzymes formation protein hypD,hydrogenase isoenzymes formation protein HypD,Hydrogenase maturation factor,hydrogenase expression/formation protein HypD,Hydrogenase formation hypA family) b2729(protein required for maturation of hydrogenases) BN373_36991(hydrogenase expression/formation protein HypD) t2759(hydrogenase isoenzymes formation protein HypD) SL1344_2837(hydrogenase isoenzymes formation protein HypD) Cluster816 1 1 1 1 1 1 1 ROD_30831(hydrogenase isoenzymes formation protein) ENC_29810(hydrogenase assembly chaperone HypC/HupF) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1048(Hydrogenase isoenzymes formation protein hypC,hydrogenase assembly chaperone,hydrogenase assembly chaperone HypC/HupF,HupF/HypC family) b2728(protein required for maturation of hydrogenases 1 and 3) BN373_36981(hydrogenase assembly chaperone HypC/HupF) t2758(hydrogenase isoenzymes formation protein HypC) SL1344_2836(hydrogenase isoenzymes formation protein HypC) Cluster817 1 1 1 1 1 1 1 ROD_30841(hydrogenase isoenzymes nickel incorporation protein) ENC_29800(hydrogenase accessory protein HypB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1049(Hydrogenase isoenzymes nickel incorporation protein hypB,hydrogenase nickel incorporation protein HypB,Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase,hydrogenase accessory protein HypB,CobW/HypB/UreG, nucleotide-binding domain) b2727(GTP hydrolase involved in nickel liganding into hydrogenases) BN373_36971(hydrogenase isoenzymes nickel incorporation protein HypB) t2757(hydrogenase isoenzymes formation protein HypB) SL1344_2835(hydrogenase isoenzymes formation protein HypB) Cluster818 1 1 1 1 1 1 1 ROD_30851(accessory protein for nickel incorporation into hydrogenase 3) ENC_29790(hydrogenase nickel insertion protein HypA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1050(hypothetical protein,hydrogenase nickel incorporation protein,Zn finger protein HypA/HybF (possibly regulating hydrogenase expression),hydrogenase nickel insertion protein HypA,Hydrogenase expression/synthesis hypA family) b2726(protein involved in nickel insertion into hydrogenases 3) BN373_36961(hydrogenase nickel insertion protein HypA) t2756(HypA protein) SL1344_2834(Probable hydrogenase nickel incorporation protein hypA) Cluster819 1 1 1 1 1 1 1 ROD_30861(formate hydrogenlyase regulatory protein) ENC_29780(Transcriptional repressor of hyc and hyp operons.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1051(Formate hydrogenlyase regulatory protein hycA,formate hydrogenlyase regulatory protein HycA,Transcriptional repressor of hyc and hyp operons) b2725(regulator of the transcriptional regulator FhlA) BN373_36951(formate hydrogenlyase regulatory protein) t2755(formate hydrogenlyase regulatory protein) SL1344_2833(formate hydrogenlyase regulatory protein) Cluster820 1 1 1 1 1 1 1 ROD_30881(formate hydrogenlyase subunit 3) ENC_29760(Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1053(Hydrogenase-4 component B,formate hydrogenlyase subunit 3,Multisubunit Na+/H+ antiporter, MnhB subunit,proton-translocating NADH-quinone oxidoreductase, chain M,NADH-Ubiquinone/plastoquinone (complex I), various chains) b2723(hydrogenase 3, membrane subunit) BN373_36931(formate hydrogenlyase, subunit C) t2753(formate hydrogenlyase subunit 3) SL1344_2831(formate hydrogenlyase subunit 3) Cluster821 1 1 1 1 1 1 1 ROD_30891(formate hydrogenlyase subunit 4) ENC_29750(Formate hydrogenlyase subunit 4) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1054(Hydrogenase 3 component D,NADH:ubiquinone oxidoreductase subunit H,NADH dehydrogenase) b2722(hydrogenase 3, membrane subunit) BN373_36921(formate hydrogenlyase, subunit D) t2752(formate hydrogenlyase subunit 4) SL1344_2830(formate hydrogenlyase subunit 4) Cluster822 1 1 1 1 1 1 1 ROD_30911(formate hydrogenlyase subunit 6) ENC_29730(Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1056(NADH-quinone oxidoreductase subunit 9,formate hydrogenlyase complex iron-sulfur subunit,Uncharacterized Fe-S center protein,NADH-quinone oxidoreductase, chain I,4Fe-4S binding domain) b2720(formate hydrogenlyase complex iron-sulfur protein) BN373_36901(formate hydrogenlyase, subunit F) t2750(formate hydrogenlyase subunit 6) SL1344_2828(formate hydrogenlyase subunit 6) Cluster823 1 1 1 1 1 1 1 ROD_30921(formate hydrogenlyase subunit 7) ENC_29720(Ni,Fe-hydrogenase III small subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1057(Hydrogenase-3 component G,NADH dehydrogenase subunit B,Ni,Fe-hydrogenase III small subunit,NADH-quinone oxidoreductase, B subunit,NADH ubiquinone oxidoreductase, 20 Kd subunit) b2719(hydrogenase 3 and formate hydrogenase complex, HycG subunit) BN373_36891(formate hydrogenlyase, subunit G) t2749(formate hydrogenlyase subunit 7) SL1344_2827(formate hydrogenlyase subunit 7) Cluster824 1 1 1 1 1 1 1 ROD_30931(formate hydrogenlyase maturation protein) ENC_29710(Formate hydrogenlyase maturation protein HycH.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1058(formate hydrogenlyase maturation protein HycH,Formate hydrogenlyase maturation protein HycH) b2718(protein required for maturation of hydrogenase 3) BN373_36881(formate hydrogenlyase maturation protein) t2748(formate hydrogenlyase maturation protein) SL1344_2826(formate hydrogenlyase maturation protein) Cluster825 1 1 1 1 1 1 1 ROD_30941(hydrogenase 3 maturation protease) ENC_29700(Hydrogenase 3 maturation peptidase Hycl. Aspartic peptidase. MEROPS family A31) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1059(Hydrogenase 3 maturation protease,hydrogenase 3 maturation protease,hydrogenase maturation peptidase HycI,Hydrogenase maturation protease) b2717(protease involved in processing C-terminal end of HycE) BN373_36871(hydrogenase maturation peptidase HycI) t2747(hydrogenase 3 maturation protease) SL1344_2825(hydrogenase 3 maturation protease) Cluster826 1 1 1 1 1 1 1 ROD_31011(electron transport protein) ENC_29640(Fe-S-cluster-containing hydrogenase components 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1063(Electron transport protein hydN,formate dehydrogenase-H ferredoxin subunit,Ferredoxin-like protein,dimethylsulfoxide reductase, chain B,4Fe-4S binding domain) b2713(formate dehydrogenase-H, [4Fe-4S] ferredoxin subunit) BN373_36821(electron transport protein HydN) t2745(electron transport protein) SL1344_2823(electron transport protein) Cluster827 1 1 1 1 1 1 1 ROD_31021(hydrogenase maturation protein) ENC_29630([NiFe] hydrogenase maturation protein HypF) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1064(Carbamoyltransferase hypF,acylphosphatase,Hydrogenase maturation factor,carbamoyltransferase HypF,yrdC domain) b2712(carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases) BN373_36811(carbamoyltransferase HypF) t2744(hydrogenase maturation protein) SL1344_2822(hydrogenase maturation protein) Cluster828 1 1 1 1 1 1 1 ROD_31031(nitric oxide reductase FlRd-NAD(+) reductase) ENC_29610(NAD(P)H-nitrite reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1065(Nitric oxide reductase FlRd-NAD(+) reductase,NADH:flavorubredoxin oxidoreductase,Uncharacterized conserved protein,nitrite reductase [NAD(P)H], large subunit,Pyridine nucleotide-disulphide oxidoreductase) b2711(NADH:flavorubredoxin oxidoreductase) BN373_36791(nitric oxide reductase FlRd-NAD(+) reductase) t2743(putative rubredoxin reductase) SL1344_2821(Nitric oxide reductase FlRd-NAD) Cluster829 1 1 1 1 1 1 1 ROD_31041(anaerobic nitric oxide reductase flavorubredoxin) ENC_29600(Uncharacterized flavoproteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1066(Anaerobic nitric oxide reductase flavorubredoxin,anaerobic nitric oxide reductase flavorubredoxin,Rubredoxin,flavodoxin,Metallo-beta-lactamas e superfamily) b2710(anaerobic nitric oxide reductase flavorubredoxin) BN373_36781(anaerobic nitric oxide reductase flavorubredoxin) t2742(putative flavoprotein) SL1344_2820(Anaerobic nitric oxide reductase flavorubredoxin) Cluster830 1 1 1 1 1 1 1 ROD_31051(anaerobic nitric oxide reductase transcription regulator) ENC_29580(Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1067(Anaerobic nitric oxide reductase transcription regulator norR,anaerobic nitric oxide reductase transcription regulator,Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,Nif-specific regulatory protein,Sigma-54 interaction domain) b2709(Anaerobic nitric oxide reductase DNA-binding transcriptional activator) BN373_36771(anaerobic nitric oxide reductase transcription regulator NorR) t2741(putative sigma-54-dependent transriptional regulator) SL1344_2819(putative sigma-54-dependent transriptional regulator) Cluster831 1 1 1 1 1 1 1 ROD_31061(D-arabinose 5-phosphate isomerase) ENC_29570(KpsF/GutQ family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1068(Arabinose 5-phosphate isomerase GutQ,D-arabinose 5-phosphate isomerase,Predicted signal-transduction protein containing cAMP-binding and CBS domains,sugar isomerase, KpsF/GutQ family,SIS domain) b2708(D-arabinose 5-phosphate isomerase) BN373_36761(gutQ protein) t2740(putative phosphosugar-binding protein) SL1344_2818(putative phosphosugar binding protein) Cluster832 1 1 1 1 1 1 1 ROD_31071(glucitol operon repressor) ENC_29560(Transcriptional regulators of sugar metabolism) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1069(Glycerol-3-phosphate regulon repressor,DNA-bindng transcriptional repressor SrlR,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,Bacterial regulatory proteins, deoR family) b2707(DNA-bindng transcriptional repressor) BN373_36751(glucitol operon repressor) t2739(glucitol operon repressor) SL1344_2817(glucitol operon repressor) Cluster833 1 1 1 1 1 1 1 ROD_31081(glucitol operon activator protein) ENC_29550(Glucitol operon activator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1070(DNA-binding transcriptional activator GutM,Glucitol operon activator,Glucitol operon activator protein (GutM)) b2706(DNA-binding transcriptional activator of glucitol operon) BN373_36741(DNA-binding transcriptional activator GutM) t2737(glucitol operon activator protein) SL1344_2816(glucitol operon activator protein) Cluster834 1 1 1 1 1 1 1 ROD_31111(glucitol/sorbitol-specific PTS system EIIB component) ENC_29520(PTS system D-sorbitol-specific IIB component, Gut family (TC 4.A.4.1.1)/PTS system D-sorbitol-specific IIC component, Gut family (TC 4.A.4.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1073(Glucitol/sorbitol-specific phosphotransferase enzyme IIB component,Phosphotransferase system sorbitol-specific component IIBC,PTS system, glucitol/sorbitol-specific, IIBC component,Sorbitol phosphotransferase enzyme II N-terminus) b2703(glucitol/sorbitol-specific enzyme IIB component of PTS) BN373_36711(glucitol/sorbitol-specific phosphotransferase enzyme iib component) t2734(glucitol/sorbitol-specific IIBC component of PTS system) SL1344_2813(PTS system, glucitol/sorbitol-specific IIBC component) Cluster835 1 1 1 1 1 1 1 ROD_31121(glucitol/sorbitol-specific PTS system EIIC component) ENC_29510(PTS system D-sorbitol-specific IIC component, Gut family (TC 4.A.4.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1074(PTS system glucitol/sorbitol-specific EIIC component,PTS system, glucitol/sorbitol-specific, IIC component,PTS system enzyme II sorbitol-specific factor) b2702(glucitol/sorbitol-specific enzyme IIC component of PTS) BN373_36701(glucitol/sorbitol permease IIC component) t2733(glucitol/sorbitol-specific IIBC component of PTS system) SL1344_2812(PTS system, glucitol/sorbitol-specific IIBC component) Cluster836 1 1 1 1 1 1 1 ROD_31131(membrane-bound lytic transglycosylase B) ENC_29500(peptidoglycan lytic transglycosylase GH103) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1075(Membrane-bound lytic murein transglycosylase B precursor,murein hydrolase B,lytic murein transglycosylase B) b2701(membrane-bound lytic murein transglycosylase B) BN373_36691(lytic murein transglycosylase B) t2732(membrane-bound lytic transglycosylase B precursor) SL1344_2811(membrane-bound lytic transglycosylase B precursor) Cluster837 1 1 1 0 2 1 1 ROD_30781(iron ABC transporter, substrate-binding protein) ENC_29460(ABC-type metal ion transport system, periplasmic component/surface adhesin) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2726(Uncharacterized periplasmic iron-binding protein HI_0362 precursor,high-affinity zinc transporter periplasmic component,ABC-type Zn2+ transport system, periplasmic component/surface adhesin,anchored repeat ABC transporter, substrate-binding protein,Periplasmic solute binding protein family) BN373_36661(cation ABC transporter, periplasmic cation-binding protein),BN373_37111(iron ABC transporter, periplasmic iron-binding protein) t2763(iron transport protein, periplasmic-binding protein) SL1344_2841(Iron transport protein, periplasmic-binding protein) Cluster838 1 1 1 1 1 1 1 ROD_31141(putative competence-damage protein) ENC_29450(competence/damage-inducible protein CinA C-terminal domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1077(hypothetical protein,hypothetical protein,Uncharacterized protein (competence- and mitomycin-induced),competence/damage-inducible protein CinA C-terminal domain,Competence-damaged protein) b2700(conserved protein) BN373_36651(competence/damage-inducible protein CinA domain protein) t2731(conserved hypothetical protein) SL1344_2810(conserved hypothetical protein) Cluster839 1 1 1 1 1 1 1 ROD_31151(RecA protein (recombinase A)) ENC_29440(RecA protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1078(Recombinase A,recombinase A,RecA-superfamily ATPases implicated in signal transduction,protein RecA,recA bacterial DNA recombination protein) b2699(DNA strand exchange and recombination protein with protease and nuclease activity) BN373_36641(protein RecA) t2730(recA protein) SL1344_2809(RecA protein) Cluster840 1 1 1 1 1 1 1 ROD_31171(alanyl-tRNA synthetase) ENC_29420(alanyl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1080(Alanine--tRNA ligase,alanyl-tRNA synthetase,Alanyl-tRNA synthetase,alanine--tRNA ligase,tRNA synthetases class II (A)) b2697(alanyl-tRNA synthetase) BN373_36621(alanyl-tRNA synthetase) t2728(alanyl-tRNA synthetase) SL1344_2807(Alanyl-tRNA synthetase) Cluster841 1 1 1 1 1 1 1 ROD_31181(carbon storage regulator) ENC_29410(carbon storage regulator (csrA)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1081(Carbon storage regulator,carbon storage regulator,carbon storage regulator,Global regulator protein family) b2696(pleiotropic regulatory protein for carbon source metabolism) BN373_36611(carbon storage regulator) t2727(carbon storage regulator) SL1344_2806(carbon storage regulator) Cluster842 1 1 1 1 1 1 1 ROD_31211(putative phosphatase) ENC_29400(haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/beta-phosphoglucomutase family hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1087(Phosphatase YqaB,fructose-1-P/6-phosphogluconate phosphatase,beta-phosphoglucomutase family hydrolase,haloacid dehalogenase-like hydrolase) b2690(fructose-1-P and 6-phosphogluconate phosphatase) BN373_36591(HAD-superfamily hydrolase, subfamily IA) t2717(conserved hypothetical protein) SL1344_2805(conserved hypothetical protein) Cluster843 1 1 1 1 1 1 1 ROD_31241(S-ribosylhomocysteinase) ENC_29370(LuxS protein involved in autoinducer AI2 synthesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1091(S-ribosylhomocysteine lyase,S-ribosylhomocysteinase,LuxS protein involved in autoinducer AI2 synthesis,S-Ribosylhomocysteinase (LuxS)) b2687(S-ribosylhomocysteine lyase) BN373_36561(S-Ribosylhomocysteinase (LuxS)) t2714(autoinducer-2 production protein LuxS) SL1344_2802(S-ribosylhomocysteinase) Cluster844 1 1 1 1 1 1 1 ROD_31261(multidrug resistance protein A) ENC_19150(Multidrug resistance efflux pump) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1095(Inner membrane protein yibH,multidrug efflux system protein EmrA,efflux pump membrane protein,HlyD family secretion protein) b2685(multidrug efflux system) BN373_36521(multidrug resistance protein A) t2711(multidrug resistance protein A) SL1344_2799(multidrug resistance protein A) Cluster845 1 1 1 1 1 1 1 ROD_31271(MarR-family transcriptional repressor) ENC_29300(Transcriptional regulators) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1096(Uncharacterized HTH-type transcriptional regulator yusO,transcriptional repressor MprA,Predicted nucleic-acid-binding protein, contains PIN domain,homoprotocatechuate degradation operon regulator, HpaR,MarR family) b2684(DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux) BN373_36511(transcriptional repressor MprA) t2710(putative transcriptional regulator) SL1344_2798(putative transcriptional regulator) Cluster846 1 1 1 1 1 1 1 ROD_31291(glycine betaine/L-proline ABC transporter, substrate-binding protein) ENC_29280(ABC-type proline/glycine betaine transport systems, periplasmic components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1100(Glycine betaine-binding periplasmic protein precursor,glycine betaine transporter periplasmic subunit,ABC-type proline/glycine betaine transport systems, periplasmic components,choline ABC transporter, periplasmic binding protein,Substrate binding domain of ABC-type glycine betaine transport system) b2679(glycine betaine transporter subunit) BN373_36481(glycine betaine/L-proline ABC transporter, periplasmic glycine betaine-binding protein) t2708(glycine betaine-binding periplasmic protein precursor) SL1344_2796(glycine betaine-binding periplasmic protein precursor) Cluster847 1 1 1 1 1 1 1 ROD_31301(glycine betaine/L-proline ABC transporter, permease protein) ENC_29270(ABC-type proline/glycine betaine transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1101(Glycine betaine/L-proline transport system permease protein proW,glycine betaine transporter membrane protein,ABC-type proline/glycine betaine transport systems, periplasmic components,choline ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component) b2678(glycine betaine transporter subunit) BN373_36471(glycine betaine/L-proline ABC transporter, permease protein) t2707(glycine betaine/L-proline transport system permease protein P) SL1344_2795(glycine betaine/L-proline transport system permease protein P) Cluster848 1 1 1 1 1 1 1 ROD_31321(ribonucleoside-diphosphate reductase 2 beta chain) ENC_29250(ribonucleoside-diphosphate reductase class Ib beta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1103(Ribonucleoside-diphosphate reductase 2 subunit beta,ribonucleotide-diphosphate reductase subunit beta,Ribonucleotide reductase, beta subunit,ribonucleoside-diphosphate reductase, class 1b, beta subunit,Ribonucleotide reductase, small chain) b2676(ribonucleoside-diphosphate reductase 2, beta subunit, ferritin-like protein) BN373_36451(ribonucleoside-diphosphate reductase, beta subunit) t2705(ribonucleoside-diphosphate reductase 2 beta chain) SL1344_2793(ribonucleoside-diphosphate reductase 2 beta chain) Cluster849 1 1 1 1 1 1 1 ROD_31341(NrdI protein) ENC_29230(ribonucleoside-diphosphate reductase 2, operon protein nrdI) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1105(hypothetical protein,ribonucleotide reductase stimulatory protein,nrdI protein,NrdI Flavodoxin like) b2674(flavodoxin required for NrdEF cluster assembly) BN373_36431(nrdI protein) t2703(NrdI protein) SL1344_2791(NrdI protein) Cluster850 1 1 1 1 1 1 1 ROD_31351(glutaredoxin-like protein) ENC_29220(ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1106(Glutaredoxin-like protein nrdH,glutaredoxin-like protein,glutaredoxin-like protein NrdH,Glutaredoxin) b2673(Hydrogen donor for NrdEF electron transport system; glutaredoxin-like protein) BN373_36421(glutaredoxin) t2702(putative glutaredoxin) SL1344_2790(putative glutaredoxin) Cluster851 1 1 1 1 1 1 1 ROD_31361(putative membrane protein) ENC_29210(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1107(hypothetical protein,Bacterial protein of unknown function (DUF883)) b2672(predicted protein) BN373_36391(conserved hypothetical protein) t2698(conserved hypothetical protein) SL1344_2786(conserved hypothetical protein) Cluster852 1 1 1 1 1 1 1 ROD_31371(conserved hypothetical protein) ENC_29200(Protein of unknown function (DUF2002).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1108(hypothetical protein,Protein of unknown function (DUF2002)) b2671(predicted protein) BN373_36381(conserved hypothetical protein) t2697(conserved hypothetical protein) SL1344_2785(conserved hypothetical protein) Cluster853 1 1 1 1 1 1 1 ROD_31381(putative membrane protein) ENC_29190(Protein of unknown function (DUF1144).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1109(L-alanine exporter AlaE,Protein of unknown function (DUF1144)) b2670(alanine exporter, alanine-inducible, stress-responsive) BN373_36371(conserved hypothetical protein) t2696(putative membrane protein) SL1344_2784(putative membrane protein) Cluster854 1 1 1 1 1 1 1 ROD_31391(DNA-binding protein) ENC_29180(nucleoid protein StpA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1110(H-NS homolog stpA,DNA binding protein, nucleoid-associated,H-NS histone family) b2669(DNA binding protein, nucleoid-associated) BN373_36351(DNA-binding protein StpA) t2695(DNA-binding protein StpA) SL1344_2783(DNA-binding protein StpA) Cluster855 1 1 1 1 1 1 1 ROD_25691(SsrA small binding protein B) ENC_28180(SsrA-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1122(Small protein B,SsrA-binding protein,SsrA-binding protein,SmpB protein) b2620(trans-translation protein) BN373_35961(SsrA-binding protein) t2642(SsrA (tmRNA)-binding protein) SL1344_2660(SsrA (tmRNA)-binding protein) Cluster856 1 1 1 1 1 1 1 ROD_25681(Conserved Hypothetical protein) ENC_28170(Oligoketide cyclase/lipid transport protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1123(Ribosome association toxin RatA,hypothetical protein,Polyketide cyclase / dehydrase and lipid transport) b2619(toxic protein, UPF0083 family) BN373_35951(polyketide cyclase/dehydrase family protein) t2641(conserved hypothetical protein) SL1344_2659(conserved hypothetical protein) Cluster857 1 1 1 1 1 1 1 ROD_25661(putative outer membrane assembly lipoprotein) ENC_28150(Small protein A (tmRNA-binding)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1125(Small protein A precursor,outer membrane biogenesis protein BamE,SmpA / OmlA family) b2617(lipoprotein component of BamABCDE OM biogenesis complex) BN373_35931(lipoprotein, SmpA/OmlA family) t2639(small protein A) SL1344_2657(small protein A) Cluster858 1 1 1 1 1 1 1 ROD_25651(DNA repair protein) ENC_28140(DNA replication and repair protein RecN) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1126(Recombination protein N,recombination and repair protein,Predicted ATPase,DNA repair protein RecN,RecF/RecN/SMC N terminal domain) b2616(recombination and repair protein) BN373_35921(DNA repair protein RecN) t2638(DNA repair protein) SL1344_2656(DNA repair protein) Cluster859 1 1 1 1 1 1 1 ROD_25641(probable inorganic polyphosphate/ATP NAD kinase) ENC_28130(Predicted sugar kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1127(Probable inorganic polyphosphate/ATP-NAD kinase,inorganic polyphosphate/ATP-NAD kinase,Predicted sugar kinase,ATP-NAD kinase) b2615(NAD kinase) BN373_35911(NAD(+) kinase) t2637(conserved hypothetical protein) SL1344_2655(conserved hypothetical protein) Cluster860 1 1 1 1 1 1 1 ROD_25631(heat shock protein (heat shock protein B25.3)) ENC_28120(Molecular chaperone GrpE (heat shock protein)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1128(Heat shock protein B25.3,heat shock protein GrpE,GrpE) b2614(heat shock protein) BN373_35901(co-chaperone GrpE) t2636(heat shock protein GrpE) SL1344_2654(heat shock protein GrpE (heat shock protein b25.3) (hsp24)) Cluster861 1 1 1 1 1 1 1 ROD_25621(putative magnesium transport protein) ENC_28110(Putative Mg2+ and Co2+ transporter CorB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1129(hypothetical protein,hypothetical protein,Putative Mg2+ and Co2+ transporter CorB,gliding motility-associated protein GldE,Domain of unknown function DUF21) b4461(inner membrane protein, UPF0053 family) BN373_35891(putative transporter) t2634(putative membrane protein) SL1344_2652(putative membrane protein) Cluster862 1 1 1 1 1 1 1 ROD_25611(putative magnesium transport protein) ENC_28100(ABC-type uncharacterized transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1130(Inner membrane protein ypjD,ABC-type uncharacterized transport system, permease component,cytochrome c-type biogenesis protein CcsB,Cytochrome C assembly protein) b2611(predicted inner membrane protein) BN373_35881(cytochrome c assembly protein) t2633(putative membrane protein) SL1344_2651(putative membrane protein) Cluster863 1 1 1 1 1 1 1 ROD_25601(signal recognition particle protein) ENC_28090(signal recognition particle subunit FFH/SRP54 (srp54)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1131(p48,signal recognition particle protein,Signal recognition particle GTPase,signal recognition particle protein,SRP54-type protein, GTPase domain) b2610(Signal Recognition Particle (SRP) component with 4.5S RNA (ffs)) BN373_35871(signal recognition particle protein) t2632(signal recognition particle protein) SL1344_2650(signal recognition particle protein) Cluster864 1 1 1 1 1 1 1 ROD_25591(30S ribosomal subunit protein S16) ENC_28080(SSU ribosomal protein S16P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1132(30S ribosomal protein S16,30S ribosomal protein S16,ribosomal protein S16,Ribosomal protein S16) b2609(30S ribosomal subunit protein S16) BN373_35861(ribosomal protein S16) t2631(30S ribosomal subunit protein S16) SL1344_2649(30S ribosomal protein S16. Chloroplast 30S ribosomal protein S16) Cluster865 1 1 1 1 1 1 1 ROD_25581(16S rRNA processing protein) ENC_28070(16S rRNA processing protein RimM) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1133(21K,16S rRNA-processing protein RimM,16S rRNA processing protein RimM,RimM N-terminal domain) b2608(16S rRNA processing protein) BN373_35851(16S rRNA processing protein RimM) t2630(16S rRNA processing protein) SL1344_2648(16S rRNA processing protein rimM. Probable 16S rRNA processing protein rimM) Cluster866 1 1 1 1 1 1 1 ROD_25571(tRNA (guanine-N(1)-)-methyltransferase) ENC_28060(tRNA (Guanine37-N(1)-) methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1134(tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase,tRNA-(guanine-N1)-methylt ransferase,tRNA (guanine(37)-N(1))-methyltransferase,tRNA (Guanine-1)-methyltransferase) b2607(tRNA m(1)G37 methyltransferase, SAM-dependent) BN373_35841(tRNA (guanine-N1)-methyltransferase) t2629(tRNA (guanine-N1) methyltransferase) SL1344_2647(tRNA (guanine-N1) methyltransferase) Cluster867 1 1 1 1 1 1 1 ROD_25561(50S ribosomal subunit protein L19) ENC_28050(LSU ribosomal protein L19P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1135(50S ribosomal protein L19,50S ribosomal protein L19,Ribosomal protein L19,ribosomal protein L19,Ribosomal protein L19) b2606(50S ribosomal subunit protein L19) BN373_35831(ribosomal protein L19) t2628(50S ribosomal subunit protein L19) SL1344_2646(50S ribosomal protein L19. Chloroplast 50S ribosomal protein L19) Cluster868 1 1 1 1 1 1 1 ROD_25541(putative signal transduction protein) ENC_28010(diguanylate cyclase (GGDEF) domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1137(Probable diguanylate cyclase YfiN,putative inner membrane diguanylate cyclase,MHYT domain (predicted integral membrane sensor domain),diguanylate cyclase (GGDEF) domain,GGDEF domain) b2604(probable inner membrane diguanylate cyclase) BN373_35791(putative diguanylate cyclase) t2627(putative membrane protein) SL1344_2630(putative membrane protein) Cluster869 1 1 1 1 1 1 1 ROD_25531(putative exported protein) ENC_28000(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1138(hypothetical protein) b2603(probable periplasmic inhibitor of YfiN activity) BN373_35781(conserved hypothetical protein) t2626(putative exported protein) SL1344_2629(putative exported protein) Cluster870 1 1 1 1 1 1 1 ROD_25521(phospho-2-dehydro-3-deoxyheptonate aldolase, tyr-sensitive) ENC_27980(phospho-2-dehydro-3-deoxyheptonate aldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1140(Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive,phospho-2-dehydro-3-deoxyheptonate aldolase,3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase,3-deoxy-7-phosphoheptulonate synthase,DAHP synthetase I family) b2601(3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tyrosine-repressible) BN373_35771(3-deoxy-7-phosphoheptulonate synthase, Tyr-sensitive) t2625(phospho-2-dehydro-3-deoxyheptonate aldolase, tyr-sensitive) SL1344_2628(phospho-2-dehydro-3-deoxyheptonate aldolase, tyr-sensitive) Cluster871 1 1 1 1 1 1 1 ROD_25511(T-protein [includes: chorismate mutase; prephenate dehydrogenase]) ENC_27970(chorismate mutase /prephenate dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1141(T-protein,bifunctional chorismate mutase/prephenate dehydrogenase,Prephenate dehydrogenase,chorismate mutase,Prephenate dehydrogenase) b2600(fused chorismate mutase T/prephenate dehydrogenase) BN373_35761(chorismate mutase/prephenate dehydrogenase) t2624(chorismate mutase) SL1344_2627(chorismate mutase/prephenate dehydrogenase) Cluster872 1 1 1 1 1 1 1 ROD_25391(P-protein) ENC_27950(chorismate mutase /prephenate dehydratase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1142(P-protein,bifunctional chorismate mutase/prephenate dehydratase,Prephenate dehydrogenase,chorismate mutase,Prephenate dehydratase) b2599(fused chorismate mutase P/prephenate dehydratase) BN373_35741(chorismate mutase/prephenate dehydratase) t2622(chorismate mutase-P) SL1344_2625(chorismate mutase-P/prephenate dehydratase) Cluster873 1 1 1 1 1 1 1 ROD_25381(ribosome-associated inhibitor A) ENC_27940(ribosomal subunit interface protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1144(SpotY,translation inhibitor protein RaiA,ribosomal subunit interface protein,Sigma 54 modulation protein / S30EA ribosomal protein) b2597(cold shock protein associated with 30S ribosomal subunit) BN373_35731(ribosomal subunit interface protein) t2620(putative sigma-54 modulation protein) SL1344_2624(putative sigma(54) modulation protein) Cluster874 1 1 1 1 1 1 1 ROD_25371(putative lipoprotein) ENC_27930(outer membrane assembly lipoprotein YfiO) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1145(hypothetical protein,outer membrane biogenesis protein BamD,DNA uptake lipoprotein,outer membrane assembly lipoprotein YfiO) b2595(lipoprotein required for OM biogenesis, in BamABCDE complex) BN373_35721(outer membrane assembly lipoprotein YfiO) t2619(putative lipoprotein) SL1344_2623(putative lipoprotein) Cluster875 1 1 1 1 1 1 1 ROD_25351(conserved hypothetical protein) ENC_27910(conserved hypothetical protein TIGR00726) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1147(Laccase domain protein yfiH,hypothetical protein,uncharacterized protein, YfiH family,Multi-copper polyphenol oxidoreductase laccase) b2593(conserved protein, UPF0124 family) BN373_35701(conserved hypothetical protein TIGR00726) t2617(conserved hypothetical protein) SL1344_2621(conserved hypothetical protein) Cluster876 1 1 1 1 1 1 1 ROD_25331(alpha-ketoglutarate permease) ENC_36730(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1152(Alpha-ketoglutarate permease,alpha-ketoglutarate transporter,Arabinose efflux permease,MFS transporter, metabolite:H+ symporter (MHS) family protein,Sugar (and other) transporter) b2587(alpha-ketoglutarate transporter) BN373_35681(alpha-ketoglutarate permease) t0256(alpha-ketoglutarate permease) SL1344_2618(alpha-ketoglutarate permease) Cluster877 1 1 1 1 1 1 1 ROD_25321(putative exported protein) ENC_36740(Predicted periplasmic lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1153(lipoprotein,Predicted periplasmic lipoprotein,Predicted periplasmic lipoprotein (DUF2279)) b2586(required for high salt suppression of motility; probable lipoprotein) BN373_35671(putative lipoprotein) t0257(conserved hypothetical protein) SL1344_2617(conserved hypothetical protein) Cluster878 1 1 1 1 1 1 1 ROD_25291(putative acyl-CoA synthetase) ENC_36760(Acyl-CoA synthetase (NDP forming)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1155(Uncharacterized conserved protein,acetyl coenzyme A synthetase (ADP forming), alpha domain,Acetyltransferase (GNAT) family) b2584(inhibiting acetyltransferase for acetyl-CoA synthetase) BN373_35651(CoA binding domain/acetyltransferase domain protein) t0259(putative acyl-CoA synthetase) SL1344_2615(putative acyl-CoA synthetase) Cluster879 1 1 1 1 1 1 1 ROD_25281(conserved hypothetical protein) ENC_36770(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1156(Uncharacterized conserved protein,DTW domain) b2583(conserved protein, DTW domain) BN373_35641(DTW domain protein) t0260(conserved hypothetical protein) SL1344_2614(conserved hypothetical protein) Cluster880 1 1 1 1 1 1 1 ROD_25271(thioredoxin 2) ENC_36780(thioredoxin) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1157(Thioredoxin-2,thioredoxin 2,Uncharacterized conserved protein,thioredoxin,Thioredoxin) b2582(thioredoxin 2) BN373_35631(putative thioredoxin) t0261(thioredoxin 2) SL1344_2613(thioredoxin 2) Cluster881 1 1 1 1 1 1 1 ROD_25251(uracil-DNA glycosylase) ENC_36810(Uracil DNA glycosylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1159(Uracil-DNA glycosylase,uracil-DNA glycosylase,uracil-DNA glycosylase,Uracil DNA glycosylase superfamily) b2580(uracil-DNA-glycosylase) BN373_35611(uracil-DNA glycosylase) t0263(uracil-DNA glycosylase) SL1344_2611(Uracil-DNA glycosylase) Cluster882 1 1 1 1 1 1 1 ROD_25241(autonomous glycyl radical cofactor) ENC_36830(Acid-induced glycyl radical enzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1160(Autonomous glycyl radical cofactor,autonomous glycyl radical cofactor GrcA,formate acetyltransferase,Glycine radical) b2579(autonomous glycyl radical cofactor) BN373_35601(autonomous glycyl radical cofactor) t0264(conserved hypothetical protein) SL1344_2610(conserved hypothetical protein) Cluster883 1 1 1 1 1 1 1 ROD_25231(ATP-dependent RNA helicase) ENC_36840(Superfamily II DNA and RNA helicases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1163(ATP-dependent RNA helicase SrmB,ATP-dependent RNA helicase SrmB,Predicted transporter component,ATP-dependent DNA helicase RecQ,DEAD/DEAH box helicase) b2576(ATP-dependent RNA helicase) BN373_35591(ATP-dependent RNA helicase SrmB) t0267(ATP-dependent RNA helicase SrmB) SL1344_2607(ATP-dependent RNA helicase SrmB) Cluster884 1 1 1 1 1 1 1 ROD_25221(putative DNA-binding protein) ENC_36850(Predicted O-methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1164(tRNA1(Val) (adenine(37)-N6)-methyltransferase,N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase,Predicted O-methyltransferase,protein-(glutamine-N5) methyltransferase, release factor-specific,Methyltransferase small domain) b2575(tRNA (adenine-N(6)-)-methyltransferase) BN373_35581(putative methyltransferase) t0268(conserved hypothetical protein) SL1344_2606(conserved hypothetical protein) Cluster885 1 1 1 1 1 1 1 ROD_25201(RNA polymerase sigma-E factor (sigma-24)) ENC_36870(RNA polymerase, sigma-24 subunit, RpoE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1166(Sigma-24,RNA polymerase sigma factor AlgU,RNA polymerase sigma factor RpoE,Sigma-70, region 4) b2573(RNA polymerase, sigma 24 (sigma E) factor) BN373_35561(RNA polymerase sigma factor RpoE) t0270(RNA polymerase sigma-E factor) SL1344_2604(RNA polymerase sigma-E factor (sigma-24)) Cluster886 1 1 1 1 1 1 1 ROD_25191(sigma-E factor negative regulator) ENC_36880(anti sigma-E protein, RseA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1167(Sigma-E factor negative regulatory protein,anti-RNA polymerase sigma factor SigE,Anti sigma-E protein RseA, N-terminal domain) b2572(anti-sigma factor) BN373_35551(sigma-E factor negative regulatory protein) t0271(sigma-E factor negative regulatory protein) SL1344_2603(sigma-E factor negative regulatory protein) Cluster887 1 1 1 1 1 1 1 ROD_25181(sigma-E factor regulatory protein) ENC_36890(sigma E regulatory protein, MucB/RseB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1168(Sigma-E factor regulatory protein rseB precursor,anti-sigma E factor,MucB/RseB family) b2571(anti-sigma E factor, binds RseA) BN373_35541(sigma-E factor regulatory protein RseB) t0272(sigma-E factor regulatory protein RseB precursor) SL1344_2602(sigma-E factor regulatory protein RseB precursor) Cluster888 1 1 1 1 1 1 1 ROD_25171(sigma-E factor regulatory protein) ENC_36900(positive regulator of sigma(E), RseC/MucC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1169(Sigma-E factor regulatory protein rseC,SoxR reducing system protein RseC,Positive regulator of sigma E activity,Positive regulator of sigma(E), RseC/MucC) b2570(RseC protein involved in reduction of the SoxR iron-sulfur cluster) BN373_35531(sigma-E factor regulatory protein RseC) t0273(sigma-E factor regulatory protein RseC) SL1344_2601(sigma-E factor regulatory protein RseC) Cluster889 1 1 1 1 1 1 1 ROD_25151(GTP-binding protein LepA) ENC_36920(GTP-binding protein LepA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1170(Elongation factor 4,GTP-binding protein LepA,GTPases - translation elongation factors,GTP-binding protein LepA,GTP-binding protein LepA C-terminus) b2569(back-translocating Elongation Factor EF4, GTPase) BN373_35521(GTP-binding protein LepA) t0274(GTP-binding protein LepA) SL1344_2545(GTP-binding protein LepA) Cluster890 1 1 1 1 1 1 1 ROD_25141(signal peptidase I) ENC_36930(signal peptidase I . Serine peptidase. MEROPS family S26A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1171(Signal peptidase I,signal peptidase I,Type IV secretory pathway, protease TraF,signal peptidase I,Peptidase S24-like) b2568(leader peptidase (signal peptidase I)) BN373_35511(signal peptidase I) t0275(signal peptidase I) SL1344_2544(signal peptidase I) Cluster891 1 1 1 1 1 1 1 ROD_25121(GTP-binding protein) ENC_36950(GTP-binding protein Era) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1173(GTP-binding protein Era,GTPase Era,Predicted GTPase,GTP-binding protein Era,GTPase of unknown function) b2566(membrane-associated, 16S rRNA-binding GTPase) BN373_35491(GTP-binding protein Era) t0276(GTP-binding protein) SL1344_2542(GTP-binding protein era homolog) Cluster892 1 1 1 1 1 1 1 ROD_25111(DNA repair protein) ENC_36960(DNA replication and repair protein RecO) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1174(Recombination protein O,DNA repair protein RecO,DNA repair protein RecO,Recombination protein O N terminal) b2565(gap repair protein) BN373_35481(DNA repair protein RecO) t0278(DNA repair protein RecO) SL1344_2541(DNA repair protein RecO) Cluster893 1 1 1 1 1 1 1 ROD_25101(pyridoxine 5'-phosphate synthase) ENC_36970(pyridoxine 5'-phosphate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1175(Pyridoxine 5'-phosphate synthase,pyridoxine 5'-phosphate synthase,pyridoxine 5'-phosphate synthase,Pyridoxal phosphate biosynthesis protein PdxJ) b2564(pyridoxine 5'-phosphate synthase) BN373_35471(pyridoxine 5'-phosphate synthase) t0279(putative pyridoxal phosphate biosynthetic protein) SL1344_2540(Pyridoxal phosphate biosynthetic protein pdxJ) Cluster894 1 1 1 1 1 1 1 ROD_25091(holo-[acyl-carrier-protein] synthase) ENC_36980(phosphopantethiene--protein transferase domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1176(Holo-[acyl-carrier-protein] synthase,4'-phosphopantetheinyl transferase,3-oxoacyl-[acyl-carrier protein] reductase,holo-[acyl-carrier-protein] synthase,4'-phosphopantetheinyl transferase superfamily) b2563(holo-[acyl-carrier-protein] synthase 1) BN373_35461(holo-(acyl-carrier-protein) synthase) t0280(holo-[acyl-carrier protein] synthase) SL1344_2539(Holo-[acyl-carrier-protein] synthase) Cluster895 1 1 1 1 1 1 1 ROD_25081(putative ferredoxin) ENC_36990(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1177(Uncharacterized ferredoxin-like protein yfhL,ferredoxin,Uncharacterized Fe-S center protein,archaeoflavoprotein, MJ0208 family,4Fe-4S dicluster domain) b2562(predicted 4Fe-4S cluster-containing protein) BN373_35451(4Fe-4S binding domain protein) t0281(putative ferredoxin) SL1344_2538(putative ferredoxin) Cluster896 1 1 1 1 1 1 1 ROD_25071(RpiR-family transcriptional regulator) ENC_37000(Transcriptional regulators) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1178(MurPQ operon repressor,putative DNA-binding transcriptional regulator,6-phospho 3-hexuloisomerase,Helix-turn-helix domain, rpiR family) b2561(predicted DNA-binding transcriptional regulator) BN373_35441(transcriptional regulator, RpiR family) t0285(putative transcriptional regulator) SL1344_2534(putative transcriptional regulator) Cluster897 1 1 1 1 1 1 1 ROD_24991(two-component system sensor kinase) ENC_37080(Signal transduction histidine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1185(Sensor histidine kinase QseE,sensory histidine kinase CreC,Predicted periplasmic ligand-binding sensor domain,phosphate regulon sensor kinase PhoR,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b2556(Sensor protein kinase regulating glmY sRNA in two-component system with response regulator GlrR) BN373_35391(sensor histidine kinase) t0292(putative sensor kinase protein) SL1344_2526(putative sensor kinase protein) Cluster898 1 1 1 1 1 1 1 ROD_24981(putative lipoprotein) ENC_37090(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1186(Quorum-sensing regulator protein G precursor,hypothetical protein) b2555(conserved protein) BN373_35381(conserved hypothetical protein) t0294(putative membrane protein) SL1344_2525(putative membrane protein) Cluster899 1 1 1 1 1 1 1 ROD_24971(two-component system response regulator) ENC_37100(Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1187(Quorum-sensing regulator protein F,response regulator GlrR,Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,nitrogen regulation protein NR(I),Sigma-54 interaction domain) b2554(Response regulator regulating glmY sRNA in two-component system with sensor protein GlrK) BN373_35371(sigma-54 dependent DNA-binding response regulator) t0293(putative transcriptional regulator) SL1344_2524(putative transcriptional regulator) Cluster900 1 1 1 1 1 1 1 ROD_24961(nitrogen regulatory protein p-II) ENC_37110(Nitrogen regulatory protein PII) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1188(Nitrogen regulatory protein P-II 1,nitrogen regulatory protein P-II 1,Nitrogen regulatory protein P-II) b2553(regulatory protein P-II for glutamine synthetase) BN373_35361(nitrogen regulatory protein P-II 1) t0295(nitrogen regulatory protein p-II) SL1344_2523(nitrogen regulatory protein p-II) Cluster901 1 1 1 1 1 1 1 ROD_24931(serine hydroxymethyltransferase) ENC_37150(serine hydroxymethyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1190(Pyridoxal-phosphate-dependent serine hydroxymethyltransferase,serine hydroxymethyltransferase,7-keto-8-aminopelargonate synthetase and related enzymes,8-amino-7-oxononanoate synthase,Serine hydroxymethyltransferase) b2551(serine hydroxymethyltransferase) BN373_35341(serine hydroxymethyltransferase) t0301(serine hydroxymethyltransferase) SL1344_2517(serine hydroxymethyltransferase) Cluster902 1 1 1 1 1 1 1 ROD_24881(putative 3-phenylpropionate permease) ENC_37170(Nucleoside H+ symporter.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1199(Probable 3-phenylpropionic acid transporter,putative 3-phenylpropionic acid transporter,MFS transporter, phenyl propionate permease (PPP) family,Major Facilitator Superfamily) b2536(predicted 3-phenylpropionic transporter) BN373_35271(putative 3-phenylpropionic acid transporter HcaT) t0302(putative 3-phenylpropionate permease) SL1344_2516(putative 3-phenylpropionate permease) Cluster903 1 1 1 1 1 1 1 ROD_24871(stationary phase inducible protein) ENC_37180(transcriptional antiterminator, BglG family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1200(stationary phase inducible protein CsiE,PRD domain) b2535(stationary phase inducible protein) BN373_35261(stationary phase-inducible protein CsiE) t0303(stationary phase inducible protein CsiE) SL1344_2515(stationary phase inducible protein CsiE) Cluster904 1 1 1 1 1 1 1 ROD_24771(inositol-1-monophosphatase) ENC_37210(Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1202(Inositol-1-monophosphatase,inositol monophosphatase,histidinol-phosphatase,Inositol monophosphatase family) b2533(inositol monophosphatase) BN373_35221(inositol-1-monophosphatase) t0310(extragenic suppressor protein SuhB) SL1344_2508(extragenic suppressor protein SuhB) Cluster905 1 1 1 1 1 1 1 ROD_24761(putative RNA methyltransferase) ENC_37220(RNA methyltransferase, TrmH family, group 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1203(tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ,tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ,RNA methyltransferase, TrmH family, group 1,SpoU rRNA Methylase family) b2532(tRNA mC32/mU32 methyltransferase, SAM-dependent) BN373_35211(RNA methyltransferase, TrmH family, group 1) t0311(putative RNA methyltransferase) SL1344_2507(putative RNA methyltransferase) Cluster906 1 1 1 1 1 1 1 ROD_24751(transcriptional regulator) ENC_37230(transcriptional regulator, BadM/Rrf2 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1204(HTH-type transcriptional regulator iscR,DNA-binding transcriptional regulator IscR,iron-sulfur cluster assembly transcription factor IscR,Transcriptional regulator) b2531(DNA-binding transcriptional repressor) BN373_35201(iron-sulfur cluster assembly transcription factor IscR) t0312(conserved hypothetical protein) SL1344_2506(conserved hypothetical protein) Cluster907 1 1 1 1 1 1 1 ROD_24741(putative L-cysteine desulfurase,cysteine desulfurase) ENC_37240(cysteine desulfurase IscS) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1206(Cysteine desulfurase,cysteine desulfurase,Uncharacterized protein conserved in bacteria,cysteine desulfurase IscS,Aminotransferase class-V) b2530(cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent) BN373_35191(cysteine desulfurase IscS) t0313(putative L-cysteine desulfurase) SL1344_2505(Cysteine desulfurase) Cluster908 1 1 1 1 1 1 1 ROD_24731(iron-sulfur cluster assembly protein) ENC_37250(FeS cluster assembly scaffold IscU) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1207(NifU-like protein,scaffold protein,FeS cluster assembly scaffold IscU,NifU-like N terminal domain) b2529(iron-sulfur cluster assembly scaffold protein) BN373_35181(FeS cluster assembly scaffold IscU) t0314(NifU-like protein) SL1344_2504(NifU-like protein) Cluster909 1 1 1 1 1 1 1 ROD_24721(iron-binding protein (iron-sulfur cluster assembly protein)) ENC_37260(iron-sulfur cluster assembly protein IscA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1208(Iron-sulfur cluster assembly protein,iron-sulfur cluster assembly protein,iron-sulfur cluster assembly protein IscA,Iron-sulphur cluster biosynthesis) b2528(FeS cluster assembly protein) BN373_35171(iron-sulfur cluster assembly protein IscA) t0315(conserved hypothetical protein) SL1344_2503(conserved hypothetical protein) Cluster910 1 1 1 1 1 1 1 ROD_24711(co-chaperone protein) ENC_37270(Fe-S protein assembly co-chaperone HscB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1209(Hsc20,co-chaperone HscB,Fe-S protein assembly co-chaperone HscB,HSCB C-terminal oligomerisation domain) b2527(DnaJ-like molecular chaperone specific for IscU) BN373_35161(Fe-S protein assembly co-chaperone HscB) t0316(chaperone protein HscB) SL1344_2502(Co-chaperone protein hscB) Cluster911 1 1 1 1 1 1 1 ROD_24701(Chaperone protein) ENC_37280(Fe-S protein assembly chaperone HscA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1210(Hsc66,chaperone protein HscA,Ethanolamine utilization protein, possible chaperonin,Fe-S protein assembly chaperone HscA,Hsp70 protein) b2526(DnaK-like molecular chaperone specific for IscU) BN373_35151(Fe-S protein assembly chaperone HscA) t0317(chaperone protein HscA) SL1344_2501(Chaperone protein hscA) Cluster912 1 1 1 1 1 1 1 ROD_24691(2Fe-2S ferredoxin) ENC_37290(ferredoxin, 2Fe-2S type, ISC system) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1211(2Fe-2S ferredoxin,CDP-6-deoxy-delta-3,4-glucoseen reductase,Uncharacterized anaerobic dehydrogenase,ferredoxin, 2Fe-2S type, ISC system,2Fe-2S iron-sulfur cluster binding domain) b2525([2Fe-2S] ferredoxin) BN373_35141(ferredoxin, 2Fe-2S type, ISC system) t0318(ferredoxin) SL1344_2500(ferredoxin) Cluster913 1 1 1 1 1 1 1 ROD_24681(putative iron-sulfur cluster biogenesis protein) ENC_37300(FeS assembly protein IscX) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1212(hypothetical protein,hypothetical protein,FeS assembly protein IscX,Protein of unknown function (DUF528)) b2524(conserved protein) BN373_35131(FeS assembly protein IscX) t0319(conserved hypothetical protein) SL1344_2499(conserved hypothetical protein) Cluster914 1 1 1 1 1 1 1 ROD_24651(3-mercaptopyruvate sulfurtransferase) ENC_37350(Rhodanese-related sulfurtransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1215(3-mercaptopyruvate sulfurtransferase,3-mercaptopyruvate sulfurtransferase,Rhodanese-like domain) b2521(3-mercaptopyruvate sulfurtransferase) BN373_35081(3-mercaptopyruvate sulfurtransferase) t0323(putative thiosulfate sulfurtransferase) SL1344_2495(putative thiosulfate sulfurtransferase) Cluster915 1 1 1 1 1 1 1 ROD_24641(putative protease inhibitor) ENC_37380(Large extracellular alpha-helical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1216(Alpha-2-macroglobulin family N-terminal region) b2520(conserved protein) BN373_35071(alpha-2-macroglobulin domain protein) t0324(putative lipoprotein) SL1344_2494(putative lipoprotein) Cluster916 1 1 1 1 1 1 1 pseudoROD_24621(penicillin-binding protein 1C (pseudogene)) ENC_37390(penicillin-binding protein 1C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1217(Penicillin-binding protein 1A/1B,penicillin-binding protein 1C,Membrane carboxypeptidase/penicillin-binding protein PbpC,penicillin-binding protein 1C,Transglycosylase) b2519(penicillin-binding protein PBP1C murein transglycosylase; inactive transpeptidase domain) BN373_35061(penicillin-binding protein 1C) t0325(penicillin-binding protein 1C) SL1344_2493(penicillin-binding protein 1C) Cluster917 1 1 1 1 1 1 1 ROD_24601(radical SAM superfamily protein) ENC_37450(23S rRNA m(2)A-2503 methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1219(Ribosomal RNA large subunit methyltransferase N,ribosomal RNA large subunit methyltransferase N,23S rRNA m2A2503 methyltransferase,Radical SAM superfamily) b2517(23S rRNA m(2)A2503 methyltransferase, SAM-dependen) BN373_35041(radical SAM enzyme, Cfr family) t0331(conserved hypothetical protein) SL1344_2487(conserved hypothetical protein) Cluster918 1 1 1 1 1 1 1 ROD_24591(putative regulatory protein) ENC_37460(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1220(Cytoskeleton protein rodZ,cytoskeletal protein RodZ,Uncharacterized protein conserved in bacteria,transcriptional regulator, y4mF family,Helix-turn-helix domain) b2516(cytoskeletal protein required for MreB assembly) BN373_35031(helix-turn-helix DNA-binding domain protein) t0332(putative DNA-binding protein) SL1344_2486(putative DNA-binding protein) Cluster919 1 1 1 1 1 1 1 ROD_24551(putative dehydrogenase) ENC_37500(outer membrane assembly lipoprotein YfgL) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1224(Lipoprotein yfgL precursor,outer membrane biogenesis protein BamB,Glucose dehydrogenase,outer membrane assembly lipoprotein YfgL,PQQ enzyme repeat) b2512(lipoprotein required for OM biogenesis, in BamABCDE complex) BN373_34991(outer membrane assembly lipoprotein YfgL) t0336(putative lipoprotein) SL1344_2482(putative lipoprotein) Cluster920 1 1 1 1 1 1 1 ROD_24531(conserved hypothetical protein) ENC_37550(Protein of unknown function (DUF1407).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1226(hypothetical protein,Protein of unknown function (DUF1407)) b2510(conserved protein, DUF1407 family) BN373_34961(conserved hypothetical protein) t0338(conserved hypothetical protein) SL1344_2480(conserved hypothetical protein) Cluster921 1 1 1 1 1 1 1 ROD_24481(GMP synthase [glutamine-hydrolyzing]) ENC_37610(GMP synthase (glutamine-hydrolyzing)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1232(GMP synthase [glutamine-hydrolyzing],GMP synthase,3-methyladenine DNA glycosylase,GMP synthase (glutamine-hydrolyzing), C-terminal domain,GMP synthase C terminal domain) b2507(GMP synthetase (glutamine aminotransferase)) BN373_34931(GMP synthase (glutamine-hydrolyzing)) t0347(GMP synthase) SL1344_2471(GMP synthase [glutamine-hydrolyzing]) Cluster922 1 1 1 1 1 1 1 ROD_24461(putative signal transduction protein) ENC_37760(FOG: EAL domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1237(Cyclic di-GMP phosphodiesterase YfgF,RNase II stability modulator,Predicted signal transduction protein containing sensor and EAL domains,MASE1) b2503(cyclic-di-GMP phosphodiesterase, anaerobic) BN373_34871(cyclic diguanylate phosphodiesterase (EAL) domain protein) t0354(putative membrane protein) SL1344_2466(putative membrane protein) Cluster923 1 1 1 1 1 1 1 ROD_24451(exopolyphosphatase) ENC_37770(Exopolyphosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1238(Exopolyphosphatase,exopolyphosphatase,exopolyphos phatase,Ppx/GppA phosphatase family) b2502(exopolyphosphatase) BN373_34861(exopolyphosphatase) t0355(exopolyphosphatase) SL1344_2465(exopolyphosphatase) Cluster924 1 1 1 1 1 1 1 ROD_24441(polyphosphate kinase) ENC_37780(Polyphosphate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1239(Polyphosphate kinase,polyphosphate kinase,polyphosphate kinase 1,Polyphosphate kinase) b2501(polyphosphate kinase, component of RNA degradosome) BN373_34851(polyphosphate kinase) t0356(polyphosphate kinase) SL1344_2464(Polyphosphate kinase) Cluster925 1 1 1 1 1 1 1 ROD_24431(phosphoribosylglycinamide formyltransferase 1) ENC_37790(formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1240(Phosphoribosylglycinamide formyltransferase,phosphoribosylglycinamide formyltransferase,Folate-dependent phosphoribosylglycinamide formyltransferase PurN,phosphoribosylglycinamide formyltransferase,Formyl transferase) b2500(phosphoribosylglycinamide formyltransferase 1) BN373_34841(phosphoribosylglycinamide formyltransferase) t0357(phosphoribosylglycinamidine myltransferase) SL1344_2463(phosphoribosylglycinamidine myltransferase) Cluster926 1 1 1 1 1 1 1 ROD_24401(uracil permease) ENC_37840(uracil-xanthine permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1243(Uracil transporter,uracil transporter,Permeases,uracil-xanthine permease,Permease family) b2497(uracil permease) BN373_34791(uracil permease) t0360(uracil permease) SL1344_2460(uracil permease (uracil transporter)) Cluster927 1 1 1 1 1 1 1 ROD_24361(putative glutaredoxin) ENC_37900(arsenate reductase (glutaredoxin)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1245(hypothetical protein,arsenate reductase,Arsenate reductase and related proteins, glutaredoxin family,arsenate reductase (glutaredoxin),ArsC family) b2495(predicted oxidoreductase) BN373_34761(arsenate reductase homolog) t0362(putative arsenate reductase) SL1344_2458(putative arsenate reductase (arsenical pump modifier)) Cluster928 1 1 1 1 1 1 1 ROD_24351(putative peptidase) ENC_37910(Putative Zn-dependent protease, contains TPR repeats) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1246(Putative Zn-dependent protease, contains TPR repeats,putative PEP-CTERM system TPR-repeat lipoprotein,Peptidase family M48) b2494(predicted peptidase, has TPR repeats) BN373_34751(peptidase, M48 family) t0363(putative exported protein) SL1344_2457(putative exported protein) Cluster929 1 1 1 1 1 1 1 ROD_24331(putative permease) ENC_37920(Predicted permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1247(hypothetical protein,pheromone autoinducer 2 transporter,sporulation integral membrane protein YtvI,Domain of unknown function DUF20) b2493(predicted inner membrane permease, UPF0118 family) BN373_34741(putative permease PerM) t0364(putative membrane protein) SL1344_2456(putative membrane protein) Cluster930 1 1 1 1 1 1 1 ROD_24291(putative peroxiredoxin (bacterioferritin comigratory protein)) ENC_37930(Peroxiredoxin) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1248(Putative peroxiredoxin bcp,thioredoxin-dependent thiol peroxidase,peroxiredoxin,AhpC/TSA family) b2480(thiol peroxidase, thioredoxin-dependent) BN373_34731(putative peroxiredoxin) t0368(bacterioferritin comigratory protein) SL1344_2454(bacterioferritin comigratory protein) Cluster931 1 1 1 1 1 1 1 ROD_24271(dihydrodipicolinate synthase) ENC_37950(dihydrodipicolinate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1250(Dihydrodipicolinate synthase,dihydrodipicolinate synthase,dihydrodipicolinate synthase,Dihydrodipicolinate synthetase family) b2478(dihydrodipicolinate synthase) BN373_34711(dihydrodipicolinate synthase) t0370(dihydrodipicolinate synthase) SL1344_2452(Dihydrodipicolinate synthase) Cluster932 1 1 1 1 1 1 1 ROD_24261(lipoprotein) ENC_37960(Uncharacterized lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1251(Lipoprotein 34 precursor,lipoprotein,NlpB/DapX lipoprotein) b2477(lipoprotein required for OM biogenesis, in BamABCDE complex) BN373_34701(lipoprotein, NlpB/DapX family) t0371(putative lipoprotein) SL1344_2451(putative lipoprotein) Cluster933 1 1 1 1 1 1 1 ROD_24251(phosphoribosylaminoimidazole-succinocarboxamide synthase) ENC_37970(phosphoribosylaminoimidazole-succinocarboxamide synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1253(Phosphoribosylaminoimidazole-succinocarboxamide synthase,phosphoribosylaminoimidazole-succinocarboxamide synthase,Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase,phosphoribosylaminoimidazolesuccinocarboxamide synthase,SAICAR synthetase) b2476(phosphoribosylaminoimidazole-succinocarboxamide synthetase) BN373_34691(phosphoribosylaminoimidazole-succinocarboxamide synthase) t0372(phosphoribosylaminoimidazole-succinocarboxamide synthase) SL1344_2450(phosphoribosylaminoimidazole-succinocarboxamide synthase) Cluster934 1 1 1 1 1 1 1 ROD_24241(putative peptidase) ENC_37980(Predicted metalloprotease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1254(Predicted metalloprotease,Putative neutral zinc metallopeptidase) b2475(conserved protein) BN373_34681(conserved hypothetical protein) t0373(putative membrane protein) SL1344_2449(putative membrane protein) Cluster935 1 1 1 1 1 1 1 ROD_24231(putative ATP-dependent acetyltransferase) ENC_37990(tRNA(Met)-cytidine N(4)-acetyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1255(tRNA(Met) cytidine acetyltransferase TmcA,Putative ATPase (DUF699)) b2474(elongator methionine tRNA (ac4C34) acetyltransferase) BN373_34671(conserved hypothetical protein) t0374(conserved hypothetical protein) SL1344_2448(conserved hypothetical protein) Cluster936 1 1 1 1 1 1 1 ROD_24211(putative exported protein) ENC_38010(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1257(hypothetical protein) b4547(predicted membrane protein, UPF0370 family) BN373_34651(conserved hypothetical protein) t0375(putative membrane protein) SL1344_2447(putative membrane protein) Cluster937 1 1 1 1 1 1 1 ROD_24201(succinyl-diaminopimelate desuccinylase) ENC_38020(succinyldiaminopimelate desuccinylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1258(Succinyl-diaminopimelate desuccinylase,succinyl-diaminopimelate desuccinylase,Metal-dependent amidase/aminoacylase/carboxypeptidase,succinyl-diaminopimel ate desuccinylase,Peptidase family M20/M25/M40) b2472(N-succinyl-diaminopimelate deacylase) BN373_34641(succinyl-diaminopimelate desuccinylase) t0376(succinyldiaminopimelate desuccinylase) SL1344_2446(succinyl-diaminopimelate desuccinylase) Cluster938 1 1 1 1 1 1 1 ROD_24191(putative glutaredoxin) ENC_38030(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1259(hypothetical protein,putative reductase,Uncharacterized protein conserved in bacteria,transcriptional regulator, Spx/MgsR family,ArsC family) b2471(predicted reductase, function unknown, ArsC family; low abundance protein) BN373_34631(ArsC family protein) t0377(conserved hypothetical protein) SL1344_2445(conserved hypothetical protein) Cluster939 1 1 1 1 1 1 1 ROD_24151(NUDIX-family hydrolase) ENC_38110(nudix hydrolase, YffH family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1263(GDP-mannose pyrophosphatase nudK,GDP-mannose pyrophosphatase NudK,nudix-type nucleoside diphosphatase, YffH/AdpP family,NUDIX domain) b2467(GDP-mannose pyrophosphatase) BN373_34601(hydrolase, NUDIX family) t0382(conserved hypothetical protein) SL1344_2440(conserved hypothetical protein) Cluster940 1 1 1 1 1 1 1 ROD_24141(putative exported protein) ENC_38120(Protein of unknown function (DUF1176).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1264(Protein of unknown function (DUF1176)) b2466(predicted protein) BN373_34591(conserved hypothetical protein) t0383(putative exported protein) SL1344_2439(putative exported protein) Cluster941 1 1 1 1 1 1 1 ROD_24121(transaldolase A) ENC_38210(transaldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1266(Transaldolase A,transaldolase A,Transaldolase,transaldolase,Transaldolase) b2464(transaldolase A) BN373_34571(transaldolase A) t0386(transaldolase A) SL1344_2436(Transaldolase) Cluster942 1 1 1 1 1 1 1 ROD_24111(NADP-dependent malic enzyme) ENC_38220(allosteric NADP-dependent malic enzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1267(NADP-dependent malic enzyme,bifunctional malic enzyme oxidoreductase/phosphotransacetylase,phosphate acetyltransferase,Phosphate acetyl/butaryl transferase) b2463(fused malic enzyme predicted oxidoreductase/predicted phosphotransacetylase) BN373_34561(malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))) t0387(NADP-dependent malate dehydrogenase) SL1344_2435(NADP-dependent malate dehydrogenase (decarboxylating)) Cluster943 1 1 1 1 1 1 1 ROD_23921(probable N-acetylmuramoyl-L-alanine amidase) ENC_38250(N-acetylmuramoyl-L-alanine amidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1286(N-acetylmuramoyl-L-alanine amidase AmiA precursor,N-acetylmuramoyl-l-alanine amidase I,N-acetylmuramoyl-L-alanine amidase CwlD,N-acetylmuramoyl-L-alanine amidase) b2435(N-acetylmuramoyl-l-alanine amidase I) BN373_34371(N-acetylmuramoyl-L-alanine amidase) t0408(probable N-acetylmuramoyl-L-alanine amidase) SL1344_2413(probable N-acetylmuramoyl-L-alanine amidase) Cluster944 1 1 1 1 1 1 1 ROD_23911(acetyltransferase ypeA) ENC_38260(Acetyltransferases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1287(Acetyltransferase YpeA,putative acetyltransferase,Predicted acetyltransferase,ribosomal-protein-alanine acetyltransferase,Acetyltransferase (GNAT) family) b2434(predicted acyltransferase with acyl-CoA N-acyltransferase domain) BN373_34361(acetyltransferase, GNAT family) t0409(putative acetyltransferase) SL1344_2412(Hypothetical acetyltransferase ) Cluster945 1 1 1 1 1 1 1 ROD_23901(putative membrane protein) ENC_38270(Protein of unknown function (DUF2919).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1288(Inner membrane protein yfeZ,Protein of unknown function (DUF2919)) b2433(inner membrane protein) BN373_34351(putative inner membrane protein YfeZ) t0410(conserved hypothetical protein) SL1344_2411(conserved hypothetical protein) Cluster946 1 1 1 1 1 1 1 ROD_23891(putative lipoprotein) ENC_38280(Protein of unknown function (DUF1131).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1289(hypothetical protein,RpoE-regulated lipoprotein,Protein of unknown function (DUF1131)) b2432(RpoE-regulated lipoprotein) BN373_34341(putative lipoprotein) t0411(putative lipoprotein) SL1344_2410(putative lipoprotein) Cluster947 1 1 1 1 1 1 1 ROD_23881(putative peroxidase) ENC_38290(Dyp-type peroxidase family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1290(Probable deferrochelatase/peroxidase YfeX,Dyp-type peroxidase family,Dyp-type peroxidase family) b2431(deferrrochelatase, cytoplasmic) BN373_34331(dyp-type peroxidase family protein) t0412(conserved hypothetical protein) SL1344_2409(conserved hypothetical protein) Cluster948 1 1 1 1 1 1 1 ROD_23861(thiosulphate ABC transporter, substrate-binding protein) ENC_38300(sulfate/thiosulfate-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1294(Thiosulfate-binding protein precursor,thiosulfate transporter subunit,ABC-type sulfate transport system, periplasmic component,sulfate ABC transporter, sulfate-binding protein,Bacterial extracellular solute-binding protein) b2425(thiosulfate-binding protein) BN373_34321(sulfate/thiosulfate ABC transporter, periplasmic thiosulfate-binding protein) t0414(thiosulphate-binding protein precursor) SL1344_2407(thiosulphate-binding protein precursor) Cluster949 1 1 1 1 1 1 1 ROD_23841(sulphate ABC transporter, permease protein) ENC_38320(sulfate ABC transporter, permease protein CysW) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1296(Sulfate transport system permease protein CysW,sulfate/thiosulfate transporter permease subunit,ABC-type sulfate transport system, permease component,sulfate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component) b2423(sulfate/thiosulfate ABC transporter subunit) BN373_34301(sulfate ABC transporter, permease protein CysW) t0416(sulphate transport system permease protein CysW) SL1344_2405(sulphate transport system permease protein CysW) Cluster950 1 1 1 1 1 1 1 ROD_23771(pyridoxine kinase) ENC_38360(Pyridoxal kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1300(Pyridoxine kinase,pyridoxal-pyridoxamine kinase/hydroxymethylpyrimidine kinase,pyridoxal kinase,Phosphomethylpyrimidine kinase) b2418(pyridoxal-pyridoxamine kinase/hydroxymethylpyrimidine kinase) BN373_34251(pyridoxal kinase) t0423(pyridoxine kinase) SL1344_2398(pyridoxine kinase) Cluster951 1 1 1 1 1 1 1 ROD_23761(glucose-specific PTS system EIIA component) ENC_38370(PTS system D-glucose-specific IIA component, Glc family (TC 4.A.1.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1301(Glucose-specific phosphotransferase enzyme IIA component,PTS system glucose-specific transporter subunit,PTS system, glucose subfamily, IIA component,phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1) b2417(glucose-specific enzyme IIA component of PTS) BN373_34231(glucose-specific phosphotransferase enzyme IIA component) t0424(glucose-specific IIA component of PTS system) SL1344_2396(pts system, glucose-specific IIA component) Cluster952 1 1 1 1 1 1 1 ROD_23751(phosphoenolpyruvate-protein phosphotransferase) ENC_38380(phosphoenolpyruvate--protein phosphotransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1302(Phosphoenolpyruvate-protein phosphotransferase,phosphoenolpyruvate-protein phosphotransferase,Uncharacterized protein conserved in bacteria,phosphoenolpyruvate-protein phosphotransferase,PEP-utilising enzyme, TIM barrel domain) b2416(PEP-protein phosphotransferase of PTS system (enzyme I)) BN373_34221(phosphoenolpyruvate-protein phosphotransferase) t0425(hypothetical protein) SL1344_2395(phosphoenolpyruvate-protein phosphotransferase (ec 2.7.3.9) (phosphotransferase system, enzyme i)) Cluster953 1 1 1 1 1 1 1 ROD_23741(phosphocarrier protein HPr) ENC_38390(Phosphotransferase System HPr (HPr) Family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1303(Phosphocarrier protein HPr,PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr,Uncharacterized protein conserved in bacteria,phosphocarrier, HPr family,PTS HPr component phosphorylation site) b2415(phosphohistidinoprotein-hexose phosphotransferase component of PTS system (Hpr)) BN373_34211(phosphocarrier protein HPr) t0426(phosphocarrier protein HPr) SL1344_2394(phosphocarrier protein HPr) Cluster954 1 1 1 1 1 1 1 ROD_23731(cysteine synthase A) ENC_38400(cysteine synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1304(Cysteine synthase A,cysteine synthase A,Cysteine synthase,cysteine synthase A,Pyridoxal-phosphate dependent enzyme) b2414(cysteine synthase A, O-acetylserine sulfhydrolase A subunit) BN373_34191(cysteine synthase A) t0427(cysteine synthase A) SL1344_2393(cysteine synthase A) Cluster955 1 1 1 1 1 1 1 ROD_23721(putative sulfate transport protein) ENC_38410(Uncharacterized protein involved in cysteine biosynthesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1305(hypothetical protein,putative sulfate transport protein CysZ,Uncharacterized protein involved in cysteine biosynthesis,Etoposide-induced protein 2.4 (EI24)) b2413(predicted inner membrane protein) BN373_34181(CysZ protein) t0428(putative sulfate transport protein CysZ) SL1344_2392(putative sulfate transport protein CysZ) Cluster956 1 1 1 1 1 1 1 ROD_23711(cell division protein) ENC_38420(cell division protein ZipA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1306(Cell division protein ZipA,cell division protein ZipA,cell division protein ZipA,ZipA, C-terminal FtsZ-binding domain) b2412(cell division protein involved in Z ring assembly) BN373_34171(cell division protein ZipA) t0429(cell division protein) SL1344_2391(cell division protein) Cluster957 1 1 1 1 1 1 1 ROD_23681(putative outer membrane protein) ENC_38460(Predicted Na+-dependent transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1309(hypothetical protein) b2410(predicted inner membrane protein) BN373_34141(transporter, bile acid/Na+ symporter family) t0432(putative membrane protein) SL1344_2388(putative membrane protein) Cluster958 1 1 1 1 1 1 1 ROD_23671(LysR-family transcriptional regulator) ENC_38470(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1310(Cyn operon transcriptional activator,DNA-binding transcriptional regulator CynR,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b2409(predicted DNA-binding transcriptional regulator) BN373_34131(transcriptional regulator, LysR family) t0433(putative transcriptional regulator) SL1344_2387(putative transcriptional regulator) Cluster959 1 1 1 1 1 1 1 ROD_28181(glutamyl-tRNA synthetase) ENC_38500(glutamyl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1319(Glutamate--tRNA ligase,glutamyl-tRNA synthetase,Glutamyl- and glutaminyl-tRNA synthetases,glutamate--tRNA ligase,tRNA synthetases class I (E and Q), catalytic domain) b2400(glutamyl-tRNA synthetase) BN373_34121(glutamyl-tRNA synthetase) t0442(glutamyl-tRNA synthetase) SL1344_2381(Glutamyl-tRNA synthetase) Cluster960 1 1 1 1 1 1 1 ROD_28161(putative regulatory protein) ENC_38520(Putative transcription regulator (DUF1323).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1321(Putative transcription regulator (DUF1323)) b2398(predicted DNA-binding protein, DUF1323 family) BN373_34101(conserved hypothetical protein) t0444(conserved hypothetical protein) SL1344_2379(conserved hypothetical protein) Cluster961 1 1 1 1 1 1 1 ROD_28101(putative exported protein) ENC_38570(Protein of unknown function (DUF2502).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1326(Protein of unknown function (DUF2502)) b2390(conserved protein) BN373_34061(conserved hypothetical protein) t0450(conserved hypothetical protein) SL1344_2375(conserved hypothetical protein) Cluster962 1 1 1 1 1 1 1 ROD_28071(putative voltage gated chloride channel protein) ENC_38600(Chloride channel protein EriC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1327(putative ion channel protein,Voltage gated chloride channel) b2389(predicted ion channel protein) BN373_34031(chloride transporter, chloride channel (ClC) family) t0453(putative membrane protein) SL1344_2372(putative membrane protein) Cluster963 1 1 1 1 1 1 1 ROD_28061(Glucokinase) ENC_38610(glucokinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1328(Glucokinase,glucokinase,Glucokinase,glucokinase,G lucokinase) b2388(glucokinase) BN373_34021(glucokinase) t0454(glucokinase) SL1344_2371(Glucokinase) Cluster964 1 1 1 1 1 1 1 ROD_27941(putative aminotransferase) ENC_38650(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1337(LL-diaminopimelate aminotransferase,aminotransferase,Alanine-alpha-ketoisovale rate (or valine-pyruvate) aminotransferase,LL-diaminopimelate aminotransferase,Aminotransferase class I and II) b2379(valine-pyruvate aminotransferase 3) BN373_33991(aminotransferase, classes I and II) t0455(putative aminotransferase) SL1344_2370(putative aminotransferase) Cluster965 1 0 2 1 1 0 2 ROD_26141(hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1810(Protein of unknown function (DUF968)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2564(Protein of unknown function (DUF968)) b1560(Qin prophage; predicted protein) BN373_33781(conserved hypothetical protein) SL1344_1960(predicted bacteriophage protein),SL1344_2216(predicted bacteriophage protein) Cluster966 1 1 1 1 1 1 1 ROD_27501(putative membrane protein) ENC_38690(Formate/nitrite family of transporters) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1366(Inner membrane protein yfdC,Formate/nitrite family of transporters,formate/nitrite transporter,Formate/nitrite transporter) b2347(predicted inner membrane protein) BN373_33381(putative membrane protein) t0471(putative membrane protein) SL1344_2362(putative membrane protein) Cluster967 1 1 1 1 1 1 1 ROD_27491(lipoprotein) ENC_38700(Surface lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1367(Probable phospholipid-binding lipoprotein mlaA precursor,ABC transporter outer membrane lipoprotein,VacJ like lipoprotein) b2346(ABC transporter maintaining OM lipid asymmetry, OM lipoprotein component) BN373_33371(lipoprotein, VacJ family) t0472(VacJ lipoprotein precursor) SL1344_2361(VacJ lipoprotein precursor) Cluster968 1 1 1 1 1 1 1 ROD_27481(long-chain fatty acid transport protein) ENC_38710(Long-chain fatty acid transport protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1368(Outer membrane flp protein,long-chain fatty acid outer membrane transporter,Outer membrane protein transport protein (OMPP1/FadL/TodX)) b2344(long-chain fatty acid outer membrane transporter) BN373_33361(long-chain fatty acid transport protein) t0473(long-chain fatty acid transport protein precursor) SL1344_2360(long-chain fatty acid transport protein precursor) Cluster969 1 1 1 1 1 1 1 ROD_27471(conserved hypothetical protein) ENC_38720(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1369(hypothetical protein,hypothetical protein,conserved hypothetical protein,Protein of unknown function (DUF406)) b2343(conserved protein, UPF0381 family) BN373_33351(conserved hypothetical protein) t0474(conserved hypothetical protein) SL1344_2359(conserved hypothetical protein) Cluster970 1 1 1 1 1 1 1 ROD_27461(fatty acid oxidation comple beta subunit (3-ketoacyl-CoA thiolase)) ENC_38730(3-ketoacyl-CoA thiolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1370(3-ketoacyl-CoA thiolase,3-ketoacyl-CoA thiolase,Transcription-associated recombination protein,acetyl-CoA C-acyltransferase FadI,Thiolase, N-terminal domain) b2342(beta-ketoacyl-CoA thiolase, anaerobic, subunit) BN373_33341(acetyl-CoA C-acyltransferase FadI) t0475(putative 3-ketoacyl-CoA thiolase) SL1344_2358(putative 3-ketoacyl-CoA thiolase) Cluster971 1 1 1 1 1 1 1 ROD_27451(fatty acid oxidation complex alpha subunit [includes: enoyl-CoA hydratase; 3-hydroxyacyl-CoA dehydrogenase; 3-hydroxybutyryl-CoA epimerase]) ENC_38740(short chain enoyl-CoA hydratase /3-hydroxyacyl-CoA dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1371(Fatty acid oxidation complex subunit alpha,multifunctional fatty acid oxidation complex subunit alpha,Predicted nucleic-acid-binding protein containing a Zn-ribbon,fatty oxidation complex, alpha subunit FadJ,3-hydroxyacyl-CoA dehydrogenase, NAD binding domain) b2341(fused enoyl-CoA hydratase and epimerase and isomerase/3-hydroxyacyl-CoA dehydrogenase) BN373_33331(fatty oxidation complex, alpha subunit FadJ) t0476(putative fatty acid oxidation complex alpha subunit) SL1344_2357(putative fatty acid oxidation complex alpha subunit) Cluster972 1 1 1 1 1 1 1 ROD_27441(phosphohistidine phosphatase) ENC_38750(phosphohistidine phosphatase SixA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1372(Phosphohistidine phosphatase sixA,phosphohistidine phosphatase,phosphohistidine phosphatase SixA,Histidine phosphatase superfamily (branch 1)) b2340(phosphohistidine phosphatase) BN373_33321(phosphohistidine phosphatase SixA) t0477(phosphohistidine phosphatase) SL1344_2356(phosphohistidine phosphatase) Cluster973 1 1 1 1 1 1 1 ROD_27431(conserved hypothetical protein) ENC_38760(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1380(hypothetical protein,Smr domain) b2331(predicted DNA endonuclease) BN373_33311(Smr domain protein) t0478(conserved hypothetical protein) SL1344_2355(conserved hypothetical protein) Cluster974 1 1 1 1 1 1 1 ROD_27411(chorismate synthase) ENC_38780(chorismate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1382(Chorismate synthase,chorismate synthase,Chorismate synthase,chorismate synthase,Chorismate synthase) b2329(chorismate synthase) BN373_33291(chorismate synthase) t0480(chorismate synthase) SL1344_2353(Chorismate synthase) Cluster975 1 1 1 1 1 1 1 ROD_27401(penicillin-insensitive murein endopeptidase) ENC_38790(murein endopeptidase. Metallo peptidase. MEROPS family M74) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1383(Penicillin-insensitive murein endopeptidase precursor,penicillin-insensitive murein endopeptidase,Penicillin-insensitive murein endopeptidase) b2328(murein DD-endopeptidase) BN373_33281(penicillin-insensitive murein endopeptidase) t0481(penicillin-insensitive murein endopeptidase precursor) SL1344_2352(penicillin-insensitive murein endopeptidase precursor) Cluster976 1 1 1 1 1 1 1 ROD_27391(putative exported protein) ENC_38800(Predicted permeases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1384(hypothetical protein,hypothetical protein,Sulfite exporter TauE/SafE) b2327(inner membrane protein, UPF0721 family) BN373_33271(putative membrane protein) t0482(putative membrane protein) SL1344_2351(putative membrane protein) Cluster977 1 1 1 1 1 1 1 ROD_27351(3-oxoacyl-[acyl-carrier-protein] synthase I) ENC_38840(3-oxoacyl-[acyl-carrier-protein] synthase I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1388(3-oxoacyl-[acyl-carrier-protein] synthase 1,3-oxoacyl-(acyl carrier protein) synthase I,Enoyl reductase domain of yeast-type FAS1,beta-ketoacyl-acyl-carrier-protein synthase II,Beta-ketoacyl synthase, N-terminal domain) b2323(3-oxoacyl-[acyl-carrier-protein] synthase I) BN373_33231(3-oxoacyl-[acyl-carrier-protein] synthase 1) t0486(3-oxoacyl-[acyl-carrier-protein] synthase I) SL1344_2347(3-oxoacyl-[acyl-carrier-protein] synthase I) Cluster978 1 1 1 1 1 1 1 ROD_27341(major facilitator superfamily protein) ENC_38850(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1389(hypothetical protein,putative transporter,Arabinose efflux permease,D-galactonate transporter,Major Facilitator Superfamily) b2322(predicted transporter) BN373_33221(transporter, major facilitator family) t0492(putative transmembrane transporter) SL1344_2341(putative transmembrane transporter) Cluster979 1 1 1 1 1 1 1 ROD_27331(cell division protein) ENC_38860(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1390(Flagellar regulator flk,flagella biosynthesis regulator) b2321(predicted flagella assembly protein) BN373_33211(div protein) t0493(Div protein) SL1344_2340(Div protein) Cluster980 1 1 1 1 1 1 1 ROD_27311(putative semialdehyde dehydrogenase) ENC_38880(Aspartate-semialdehyde dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1392(USG-1 protein,putative semialdehyde dehydrogenase,Aspartate-semialdehyde dehydrogenase,aspartate-semialdehyde dehydrogenase,Semialdehyde dehydrogenase, dimerisation domain) b2319(predicted semialdehyde dehydrogenase) BN373_33191(aspartate-semialdehyde dehydrogenase family protein) t0495(putative semialdehyde dehydrogenase) SL1344_2338(putative semialdehyde dehydrogenase) Cluster981 1 1 1 1 1 1 1 ROD_27301(tRNA pseudouridine synthase A) ENC_38890(pseudouridylate synthase I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1393(tRNA pseudouridine synthase A,tRNA pseudouridine synthase A,tRNA pseudouridine(38-40) synthase,tRNA pseudouridine synthase) b2318(pseudouridylate synthase I) BN373_33181(tRNA pseudouridine synthase A) t0496(tRNA pseudouridine synthase A) SL1344_2337(tRNA pseudouridine synthase A) Cluster982 1 1 1 1 1 1 1 ROD_27291(putative membrane protein) ENC_38900(Uncharacterized membrane-associated protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1394(hypothetical protein,hypothetical protein,SNARE associated Golgi protein) b2317(conserved inner membrane protein) BN373_33171(membrane protein, DedA family) t0497(DedA protein) SL1344_2336(DedA protein (dsg-1 protein)) Cluster983 1 1 1 1 1 1 1 ROD_27281(acetyl-coenzyme A carboxylase carboxyl transferase beta subunit) ENC_38910(acetyl-CoA carboxylase carboxyltransferase subunit alpha) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1395(Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta,acetyl-CoA carboxylase subunit beta,Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta),acetyl-CoA carboxylase, carboxyl transferase, beta subunit,Carboxyl transferase domain) b2316(acetyl-CoA carboxylase, beta (carboxyltransferase) subunit) BN373_33161(acetyl-CoA carboxylase, carboxyl transferase, beta subunit) t0498(acetyl-CoA carboxylase beta subunit) SL1344_2335(acetyl-CoA carboxylase beta subunit) Cluster984 1 1 1 1 1 1 1 ROD_27271(bifunctional FolC protein [includes: folylpolyglutamate synthase; dihydrofolate synthase]) ENC_38920(folylpolyglutamate synthase/dihydrofolate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1396(Bifunctional protein folC,bifunctional folylpolyglutamate synthase/ dihydrofolate synthase,Folylpolyglutamate synthase,bifunctional protein FolC,Mur ligase middle domain) b2315(bifunctional folylpolyglutamate synthase/ dihydrofolate synthase) BN373_33151(tetrahydrofolate synthase/dihydrofolate synthase) t0499(folylpolyglutamate synthase) SL1344_2334(folylpolyglutamate synthase) Cluster985 1 1 1 1 1 1 1 ROD_27241(colicin V production protein) ENC_38940(Uncharacterized membrane protein, required for colicin V production) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1398(Pur regulon 18 kDa protein,colicin V production protein,Colicin V production protein) b2313(membrane protein required for colicin V production) BN373_33131(CvpA protein) t0501(colicin V production protein) SL1344_2332(colicin V production protein (DedE protein)) Cluster986 1 1 1 1 1 1 1 ROD_27191(3-octaprenyl-4-hydroxybenzoate carboxy-lyase) ENC_38970(3-octaprenyl-4hydroxybenzoate decarboxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1400(Probable aromatic acid decarboxylase,3-octaprenyl-4-hydroxybenzoate carboxy-lyase,3-polyprenyl-4-hydroxybenzoate decarboxylase,polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases,Flavoprotein) b2311(3-octaprenyl-4-hydroxybenzoate carboxy-lyase) BN373_33111(3-octaprenyl-4-hydroxybenzoate carboxy-lyase) t0508(putative decarboxylase) SL1344_2325(putative decarboxylase) Cluster987 1 1 1 1 1 1 1 ROD_27181(lysine-arginine-ornithine-binding periplasmic protein) ENC_38980(L-arginine-binding protein/L-lysine-binding protein/L-ornithine-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1401(Lysine-arginine-ornithine-binding periplasmic protein precursor,ABC transporter lysine/arginine/ornithine binding periplasmic protein,lysine-arginine-ornithine-binding periplasmic protein,Bacterial extracellular solute-binding proteins, family 3) b2310(lysine/arginine/ornithine transporter subunit) BN373_33101(lysine-arginine-ornithine-binding periplasmic protein) t0509(lysine-arginine-ornithine-binding periplasmic protein precursor) SL1344_2324(lysine-arginine-ornithine-binding periplasmic protein precursor) Cluster988 1 1 1 1 1 1 1 ROD_27171(histidine ABC transporter, substrate-binding periplasmic protein) ENC_38990(L-histidine-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1402(Histidine-binding periplasmic protein precursor,histidine ABC transporter substrate-binding protein HisJ,lysine-arginine-ornithine-binding periplasmic protein,Bacterial extracellular solute-binding proteins, family 3) b2309(histidine/lysine/arginine/ornithine transporter subunit) BN373_33091(histidine ABC transporter, periplasmic histidine-binding protein) t0510(histidine-binding periplasmic protein) SL1344_2323(histidine-binding periplasmic protein) Cluster989 1 1 1 1 1 1 1 ROD_27161(histidine ABC transporter, permease protein) ENC_39000(L-histidine ABC transporter membrane protein/L-arginine ABC transporter membrane protein/L-lysine ABC transporter membrane protein/L-ornithine ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1403(Histidine transport system permease protein hisQ,histidine/lysine/arginine/ornithine ABC transporter permease HisQ,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component) b2308(histidine/lysine/arginine/ornithine transporter permease subunit) BN373_33081(histidine ABC transporter, permease protein HisQ) t0511(histidine transport system permease protein) SL1344_2322(histidine transport system permease protein) Cluster990 1 1 1 1 1 1 1 ROD_27141(histidine ABC transporter, ATP-binding protein) ENC_39020(L-histidine ABC transporter ATP-binding protein/L-arginine ABC transporter ATP-binding protein/L-lysine ABC transporter ATP-binding protein/L-ornithine ABC transporter ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1405(Histidine transport ATP-binding protein HisP,histidine/lysine/arginine/ornithine transporter subunit,ABC-type histidine transport system, ATPase component,ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA,ABC transporter) b2306(histidine/lysine/arginine/ornithine transporter subunit) BN373_33061(histidine ABC transporter, ATP-binding protein) t0513(histidine transport ATP-binding protein) SL1344_2320(histidine transport ATP-binding protein) Cluster991 1 1 1 1 1 1 1 ROD_27121(conserved hypothetical protein) ENC_39040(conserved hypothetical protein TIGR01777) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1406(Epimerase family protein SA0724,Uncharacterized conserved protein,conserved hypothetical protein,NAD dependent epimerase/dehydratase family) b2304(conserved protein with NAD(P)-binding Rossmann-fold domain) BN373_33041(NAD dependent epimerase/dehydratase family protein) t0514(conserved hypothetical protein) SL1344_2319(conserved hypothetical protein) Cluster992 1 1 1 1 1 1 1 ROD_27101(putative glutathione S-transferase) ENC_39060(Glutathione S-transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1408(GST-like protein yfcG,GSH-dependent disulfide bond oxidoreductase,maleylacetoacetate isomerase,Glutathione S-transferase, C-terminal domain) b2302(GSH-dependent disulfide bond oxidoreductase) BN373_33021(putative glutathione S-transferase) t0515(putative glutathione-S transferase) SL1344_2318(putative glutathione-S transferase) Cluster993 1 1 1 1 1 1 1 ROD_27091(putative glutathione S-transferase) ENC_39070(Glutathione S-transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1409(Uncharacterized GST-like protein yfcF,glutathione S-transferase,maleylacetoacetate isomerase,Glutathione S-transferase, N-terminal domain) b2301(glutathione S-transferase) BN373_33011(glutathione S-transferase domain protein) t0516(putative glutathione-S transferase) SL1344_2317(putative glutathione-S transferase) Cluster994 1 1 1 1 1 1 1 ROD_27081(putative phosphodiesterase) ENC_39080(phosphoesterase, MJ0936 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1410(Phosphodiesterase yfcE,phosphodiesterase,Uncharacterized protein conserved in bacteria,phosphodiesterase, MJ0936 family,Calcineurin-like phosphoesterase superfamily domain) b2300(phosphodiesterase activity on bis-pNPP) BN373_33001(phosphodiesterase, YfcE family) t0517(conserved hypothetical protein) SL1344_2316(conserved hypothetical protein) Cluster995 1 1 1 1 1 1 1 ROD_27071(NUDIX-family hydrolase) ENC_39090(Isopentenyldiphosphate isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1411(Uncharacterized Nudix hydrolase yfcD,NUDIX hydrolase YfcD,isopentenyl-diphosphate delta-isomerase,NUDIX domain) b2299(predicted NUDIX hydrolase) BN373_32991(hydrolase YfcD) t0518(conserved hypothetical protein) SL1344_2315(conserved hypothetical protein) Cluster996 1 1 1 1 1 1 1 ROD_26991(phosphate acetyltransferase) ENC_39140(phosphotransacetylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1413(Phosphate acetyltransferase,phosphate acetyltransferase,phosphate acetyltransferase,Phosphate acetyl/butaryl transferase) b2297(phosphate acetyltransferase) BN373_32981(phosphate acetyltransferase) t0526(phosphate acetyltransferase) SL1344_2307(phosphate acetyltransferase) Cluster997 1 1 1 1 1 1 1 ROD_26981(Acetate kinase) ENC_39150(acetate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1414(Acetate kinase,acetate kinase A/propionate kinase 2,Acetate kinase,acetate kinase,Acetokinase family) b2296(acetate kinase A and propionate kinase 2) BN373_32971(acetate kinase) t0527(acetate kinase) SL1344_2306(acetate kinase) Cluster998 1 1 1 1 1 1 1 ROD_26971(putative membrane protein) ENC_39160(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1415(hypothetical protein,hypothetical protein,Uncharacterized protein conserved in bacteria,Protein of unknown function, DUF412) b2295(inner membrane protein, UPF0208 family) BN373_32961(putative inner membrane protein YfbV) t0528(conserved hypothetical protein) SL1344_2305(conserved hypothetical protein) Cluster999 1 1 1 1 1 1 1 ROD_26961(conserved hypothetical protein) ENC_39170(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1416(hypothetical protein,hypothetical protein,YfbU domain) b2294(conserved protein, UPF0304 family) BN373_32951(YfbU domain protein) t0529(conserved hypothetical protein) SL1344_2304(Hypothetical UPF0304 protein ) Cluster1000 1 1 1 1 1 1 1 ROD_26931(5'-nucleotidase) ENC_39200(Predicted hydrolases of HD superfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1419(5'-nucleotidase yfbR,5'-nucleotidase,HD containing hydrolase-like enzyme) b2291(5'-nucleotidase) BN373_32921(5'-nucleotidase) t0532(putative oxetanocin A biosynthetic enzyme) SL1344_2301(Hypothetical UPF0207 protein ) Cluster1001 1 1 1 1 1 1 1 ROD_26921(putative aminotransferase) ENC_39210(Aspartate/tyrosine/aromatic aminotransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1420(Aspartate aminotransferase,aminotransferase AlaT,Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase,tyrosine/nicotianamine family aminotransferase,Aminotransferase class I and II) b2290(valine-pyruvate aminotransferase 2) BN373_32911(aminotransferase, classes I and II) t0533(putative aminotransferase) SL1344_2300(putative aminotransferase) Cluster1002 1 1 1 1 1 1 1 ROD_26911(NADH dehydrogenase operon transcriptional regulator) ENC_39220(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1421(HTH-type transcriptional regulator gltC,DNA-binding transcriptional repressor LrhA,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b2289(DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes) BN373_32901(transcriptional regulator LrhA) t0534(NADH dehydrogenase operon transcriptional regulator) SL1344_2299(NADH dehydrogenase operon transcriptional regulator) Cluster1003 1 1 1 1 1 1 1 ROD_26891(NADH-quinone oxidoreductase subunit B) ENC_39240(NADH dehydrogenase subunit B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1424(NADH-quinone oxidoreductase subunit B,NADH dehydrogenase subunit B,NADH:ubiquinone oxidoreductase 49 kD subunit 7,NADH-quinone oxidoreductase, B subunit,NADH ubiquinone oxidoreductase, 20 Kd subunit) b2287(NADH:ubiquinone oxidoreductase, chain B) BN373_32881(NADH-quinone oxidoreductase, B subunit) t0537(NADH dehydrogenase I chain B) SL1344_2296(NADH dehydrogenase I chain B) Cluster1004 1 1 1 1 1 1 1 ROD_26881(NADH-quinone oxidoreductase subunit C/D) ENC_39250(NADH dehydrogenase subunit C /NADH dehydrogenase subunit D) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1425(NADH-quinone oxidoreductase subunit C/D,bifunctional NADH:ubiquinone oxidoreductase subunit C/D,NADH:ubiquinone oxidoreductase 49 kD subunit 7,NADH dehydrogenase (quinone), D subunit,Respiratory-chain NADH dehydrogenase, 49 Kd subunit) b2286(NADH:ubiquinone oxidoreductase, fused CD subunit) BN373_32871(NADH-quinone oxidoreductase, C/D subunit) t0538(NADH dehydrogenase I chain C) SL1344_2295(NADH dehydrogenase I chain C; chain D) Cluster1005 1 1 1 1 1 1 1 ROD_26871(NADH-quinone oxidoreductase subunit E) ENC_39260(NADH dehydrogenase subunit E) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1426(NADH-quinone oxidoreductase subunit E,NADH dehydrogenase subunit E,NADH:ubiquinone oxidoreductase 24 kD subunit,NADH-quinone oxidoreductase, E subunit,Respiratory-chain NADH dehydrogenase 24 Kd subunit) b2285(NADH:ubiquinone oxidoreductase, chain E) BN373_32861(NADH-quinone oxidoreductase, E subunit) t0539(NADH dehydrogenase I chain E) SL1344_2294(NADH dehydrogenase I chain E) Cluster1006 1 1 1 1 1 1 1 ROD_26861(NADH-quinone oxidoreductase subunit F) ENC_39270(NADH dehydrogenase subunit F) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1427(NADH-quinone oxidoreductase subunit F,NADH dehydrogenase I subunit F,NADH:ubiquinone oxidoreductase 24 kD subunit,NADH oxidoreductase (quinone), F subunit,Respiratory-chain NADH dehydrogenase 51 Kd subunit) b2284(NADH:ubiquinone oxidoreductase, chain F) BN373_32851(NADH-quinone oxidoreductase, F subunit) t0540(NADH dehydrogenase I chain F) SL1344_2293(NADH dehydrogenase I chain F) Cluster1007 1 1 1 1 1 1 1 ROD_26851(NADH-quinone oxidoreductase subunit G) ENC_39280(NADH dehydrogenase subunit G) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1428(NADH-quinone oxidoreductase subunit G,NADH dehydrogenase subunit G,Uncharacterized anaerobic dehydrogenase,NADH dehydrogenase (quinone), G subunit,NADH-ubiquinone oxidoreductase-G iron-sulfur binding region) b2283(NADH:ubiquinone oxidoreductase, chain G) BN373_32841(NADH-quinone oxidoreductase, G subunit) t0541(NADH dehydrogenase I chain G) SL1344_2292(NADH dehydrogenase I chain G) Cluster1008 1 1 1 1 1 1 1 ROD_26841(NADH-quinone oxidoreductase subunit H) ENC_39290(NADH dehydrogenase subunit H) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1429(NADH-quinone oxidoreductase subunit H,NADH:ubiquinone oxidoreductase subunit H,NADH dehydrogenase) b2282(NADH:ubiquinone oxidoreductase, membrane subunit H) BN373_32831(NADH-quinone oxidoreductase, H subunit) t0542(NADH dehydrogenase I chain H) SL1344_2291(NADH dehydrogenase I chain H) Cluster1009 1 1 1 1 1 1 1 ROD_26831(NADH-quinone oxidoreductase subunit I) ENC_39300(NADH dehydrogenase subunit I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1430(NADH-quinone oxidoreductase subunit I,NADH dehydrogenase subunit I,Predicted NADH:ubiquinone oxidoreductase, subunit RnfC,NADH-quinone oxidoreductase, chain I,4Fe-4S binding domain) b2281(NADH:ubiquinone oxidoreductase, chain I) BN373_32821(NADH-quinone oxidoreductase, I subunit) t0543(NADH dehydrogenase I chain I) SL1344_2290(NADH dehydrogenase I chain I) Cluster1010 1 1 1 1 1 1 1 ROD_26821(NADH-quinone oxidoreductase chain J) ENC_39310(NADH dehydrogenase subunit J) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1431(NADH-quinone oxidoreductase subunit J,NADH:ubiquinone oxidoreductase subunit J,NADH-ubiquinone/plastoquinone oxidoreductase chain 6) b2280(NADH:ubiquinone oxidoreductase, membrane subunit J) BN373_32811(NADH-quinone oxidoreductase, J subunit) t0544(NADH dehydrogenase I chain J) SL1344_2289(NADH dehydrogenase I chain J) Cluster1011 1 1 1 1 1 1 1 ROD_26811(NADH-quinone oxidoreductase chain K) ENC_39320(NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1432(NADH-quinone oxidoreductase subunit K,NADH:ubiquinone oxidoreductase subunit K,NADH-ubiquinone/plastoquinone oxidoreductase chain 4L) b2279(NADH:ubiquinone oxidoreductase, membrane subunit K) BN373_32801(NADH-quinone oxidoreductase, K subunit) t0545(NADH dehydrogenase I chain k) SL1344_2288(NADH dehydrogenase I chain k) Cluster1012 1 1 1 1 1 1 1 ROD_26801(NADH-quinone oxidoreductase chain L) ENC_39330(NADH dehydrogenase subunit L) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1433(NADH-quinone oxidoreductase subunit L,NADH:ubiquinone oxidoreductase subunit L,Multisubunit Na+/H+ antiporter, MnhB subunit,proton-translocating NADH-quinone oxidoreductase, chain L,NADH-Ubiquinone/plastoquinone (complex I), various chains) b2278(NADH:ubiquinone oxidoreductase, membrane subunit L) BN373_32791(NADH-quinone oxidoreductase, L subunit) t0546(NADH dehydrogenase I chain L) SL1344_2287(NADH dehydrogenase I chain L) Cluster1013 1 1 1 1 1 1 1 ROD_26791(NADH-quinone oxidoreductase chain M) ENC_39340(NADH dehydrogenase subunit M) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1434(NADH-quinone oxidoreductase subunit M,NADH:ubiquinone oxidoreductase subunit M,Multisubunit Na+/H+ antiporter, MnhB subunit,proton-translocating NADH-quinone oxidoreductase, chain M,NADH-Ubiquinone/plastoquinone (complex I), various chains) b2277(NADH:ubiquinone oxidoreductase, membrane subunit M) BN373_32781(NADH-quinone oxidoreductase, M subunit) t0547(NADH dehydrogenase I chain M) SL1344_2286(NADH dehydrogenase I chain M) Cluster1014 1 1 1 1 1 1 1 ROD_26781(NADH-quinone oxidoreductase chain N) ENC_39350(NADH dehydrogenase subunit N) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1435(NADH-quinone oxidoreductase subunit N,NADH:ubiquinone oxidoreductase subunit N,Multisubunit Na+/H+ antiporter, MnhB subunit,proton-translocating NADH-quinone oxidoreductase, chain N,NADH-Ubiquinone/plastoquinone (complex I), various chains) b2276(NADH:ubiquinone oxidoreductase, membrane subunit N) BN373_32771(NADH-quinone oxidoreductase, N subunit) t0548(NADH dehydrogenase I chain N) SL1344_2285(NADH dehydrogenase I chain N) Cluster1015 1 1 1 1 1 1 1 pseudoROD_26751(ribonuclease Z (tRNA endonuclease) (pseudogene)) ENC_39370(RNAse Z) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1439(Ribonuclease BN,ribonuclease Z,ribonuclease BN,Beta-lactamase superfamily domain) b2268(RNase BN, tRNA processing enzyme) BN373_32761(ribonuclease Z) t0550(putative hydrolase) SL1344_2282(Ribonuclease Z) Cluster1016 1 1 1 1 1 1 1 ROD_26741(putative acetyltransferase) ENC_39380(Predicted acyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1440(hypothetical protein,putative acyltransferase,Predicted acetyltransferase,Acetyltransferase (GNAT) family) b2267(predicted acyltransferase with acyl-CoA N-acyltransferase domain) BN373_32751(acetyltransferase, GNAT family) t0551(conserved hypothetical protein) SL1344_2281(conserved hypothetical protein) Cluster1017 1 1 1 1 1 1 1 ROD_26711(menaquinone biosynthesis protein [includes: 2-succinyl-6-hydroxy 2,4-cyclohexadiene-1-carboxylate synthase; 2-oxoglutarate decarboxylase]) ENC_39410(2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxy late synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1443(2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene- 1-carboxylate synthase,2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1 -carboxylate synthase,2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1 -carboxylic-acid synthase,Thiamine pyrophosphate enzyme, N-terminal TPP binding domain) b2264(bifunctional 2-oxoglutarate decarboxylase/ SHCHC synthase) BN373_32731(2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase) t0554(menaquinone biosynthesis protein) SL1344_2278(menaquinone biosynthesis protein) Cluster1018 1 1 1 1 1 1 1 ROD_26691(naphthoate synthase) ENC_39440(1,4-Dihydroxy-2-naphthoate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1445(1,4-Dihydroxy-2-naphthoyl-CoA synthase,dihydroxynaphthoic acid synthetase,naphthoate synthase,Enoyl-CoA hydratase/isomerase family) b2262(dihydroxynaphthoic acid synthetase) BN373_32711(naphthoate synthase) t0556(naphthoate synthase) SL1344_2276(naphthoate synthase) Cluster1019 1 1 1 1 1 1 1 ROD_26681(O-succinylbenzoate synthase) ENC_39450(O-succinylbenzoate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1446(o-succinylbenzoate synthase,O-succinylbenzoate synthase,L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily,o-succinylbenzoate synthase,Mandelate racemase / muconate lactonizing enzyme, C-terminal domain) b2261(o-succinylbenzoyl-CoA synthase) BN373_32701(o-succinylbenzoic acid (OSB) synthetase) t0557(O-succinylbenzoate-CoA synthase) SL1344_2275(O-succinylbenzoate synthase) Cluster1020 1 1 1 1 1 1 1 ROD_26671(2-succinylbenzoate--CoA ligase) ENC_39460(O-succinylbenzoate-CoA ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1447(2-succinylbenzoate--CoA ligase,O-succinylbenzoic acid--CoA ligase,Uncharacterized protein conserved in bacteria,O-succinylbenzoate-CoA ligase,AMP-binding enzyme) b2260(o-succinylbenzoate-CoA ligase) BN373_32691(o-succinylbenzoate-CoA ligase) t0558(O-succinylbenzoic acid-CoA ligase) SL1344_2274(O-succinylbenzoic acid-CoA ligase) Cluster1021 1 1 1 1 1 1 1 ROD_26631(putative exported protein) ENC_39520(YfaZ precursor.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1458(YfaZ precursor) b2250(outer membrane protein, possible porin) BN373_32661(outer membrane protein, YfaZ) t0569(conserved hypothetical protein) SL1344_2263(conserved hypothetical protein) Cluster1022 1 1 1 1 1 1 1 ROD_26621(putative molybdopterin-binding protein) ENC_39530(molybdenum cofactor synthesis domain/competence/damage-inducible protein CinA N-terminal domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1459(CinA-like protein,hypothetical protein,Uncharacterized protein (competence- and mitomycin-induced),competence/damage-inducible protein CinA N-terminal domain,Probable molybdopterin binding domain) b2249(conserved protein) BN373_32651(CinA family protein) t0570(conserved hypothetical protein) SL1344_2262(conserved hypothetical protein) Cluster1023 1 1 1 1 1 1 1 ROD_26551(anaerobic glycerol-3-phosphate dehydrogenase subunit C) ENC_39540(glycerol 3-phosphate dehydrogenase (quinone) subunit C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1466(Anaerobic glycerol-3-phosphate dehydrogenase subunit C,sn-glycerol-3-phosphate dehydrogenase subunit C,Anaerobic glycerol-3-phosphate dehydrogenase,glycerol-3-phosphate dehydrogenase, anaerobic, C subunit,Cysteine-rich domain) b2243(anaerobic sn-glycerol-3-phosphate dehydrogenase, C subunit, 4Fe-4S iron-sulfur cluster) BN373_32601(glycerol-3-phosphate dehydrogenase, anaerobic, C subunit) t0578(anaerobic glycerol-3-phosphate dehydrogenase subunit C) SL1344_2255(anaerobic glycerol-3-phosphate dehydrogenase subunit C) Cluster1024 1 1 1 1 1 1 1 ROD_26541(anaerobic glycerol-3-phosphate dehydrogenase subunit B) ENC_39550(glycerol 3-phosphate dehydrogenase (quinone) subunit B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1467(Anaerobic glycerol-3-phosphate dehydrogenase subunit B,anaerobic glycerol-3-phosphate dehydrogenase subunit B,Anaerobic glycerol-3-phosphate dehydrogenase,glycerol-3-phosphate dehydrogenase, anaerobic, B subunit,FAD binding domain) b2242(sn-glycerol-3-phosphate dehydrogenase (anaerobic), membrane anchor subunit) BN373_32591(glycerol-3-phosphate dehydrogenase, anaerobic, B subunit) t0579(anaerobic glycerol-3-phosphate dehydrogenase subunit B) SL1344_2254(Anaerobic glycerol-3-phosphate dehydrogenase subunit B) Cluster1025 1 1 1 1 1 1 1 ROD_26531(anaerobic glycerol-3-phosphate dehydrogenase subunit A) ENC_39560(glycerol 3-phosphate dehydrogenase (quinone) subunit A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1468(Anaerobic glycerol-3-phosphate dehydrogenase subunit A,sn-glycerol-3-phosphate dehydrogenase subunit A,Anaerobic glycerol-3-phosphate dehydrogenase,glycerol-3-phosphate dehydrogenase, anaerobic, A subunit,FAD dependent oxidoreductase) b2241(sn-glycerol-3-phosphate dehydrogenase (anaerobic), large subunit, FAD/NAD(P)-binding) BN373_32581(glycerol-3-phosphate dehydrogenase, anaerobic, A subunit) t0580(anaerobic glycerol-3-phosphate dehydrogenase subunit A) SL1344_2253(anaerobic glycerol-3-phosphate dehydrogenase subunit A) Cluster1026 1 1 1 1 1 1 1 ROD_26521(glycerol-3-phosphate transporter) ENC_39570(glycerol-3-phosphate transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1469(G-3-P permease,sn-glycerol-3-phosphate transporter,Arabinose efflux permease,glycerol-3-phosphate transporter,Major Facilitator Superfamily) b2240(sn-glycerol-3-phosphate transporter) BN373_32571(glycerol-3-phosphate transporter) t0581(glycerol-3-phosphate transporter) SL1344_2252(glycerol-3-phosphate transporter) Cluster1027 1 1 1 1 1 1 1 ROD_26511(glycerophosphoryl diester phosphodiesterase) ENC_39580(Glycerophosphoryl diester phosphodiesterase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1470(Glycerophosphoryl diester phosphodiesterase precursor,glycerophosphodiester phosphodiesterase,Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase,Glycerophosphoryl diester phosphodiesterase family) b2239(periplasmic glycerophosphodiester phosphodiesterase) BN373_32561(glycerophosphoryl diester phosphodiesterase) t0582(glycerophosphoryl diester phosphodiesterase periplasmic precursor) SL1344_2251(glycerophosphoryl diester phosphodiesterase periplasmic precursor) Cluster1028 1 1 1 1 1 1 1 ROD_23561(ribonucleoside-diphosphate reductase 1 beta chain) ENC_39600(ribonucleoside-diphosphate reductase class Ia beta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1473(Ribonucleoside-diphosphate reductase 1 subunit beta,ribonucleotide-diphosphate reductase subunit beta,Ribonucleotide reductase, beta subunit,ribonucleoside-diphosphate reductase, class 1b, beta subunit,Ribonucleotide reductase, small chain) b2235(ribonucleoside-diphosphate reductase 1, beta subunit, ferritin-like protein) BN373_32541(ribonucleoside-diphosphate reductase, beta subunit) t0586(ribonucleoside-diphosphate reductase 1 beta chain) SL1344_2247(ribonucleoside-diphosphate reductase 1 beta chain) Cluster1029 1 1 1 1 1 1 1 ROD_23531(DNA gyrase subunit A) ENC_39630(DNA gyrase subunit A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1477(DNA gyrase subunit A,DNA gyrase subunit A,Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit,DNA gyrase, A subunit,DNA gyrase/topoisomerase IV, subunit A) b2231(DNA gyrase (type II topoisomerase), subunit A) BN373_32511(DNA gyrase, A subunit) t0592(DNA gyrase subunit A) SL1344_2241(DNA gyrase subunit A) Cluster1030 1 1 1 1 1 1 1 ROD_23501(regulator of capsule synthesis (two-component system response regulator)) ENC_39660(Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1490(Capsular synthesis regulator component B,transcriptional regulator RcsB,Response regulator,nitrogen regulation protein NR(I),Response regulator receiver domain) b2217(DNA-binding response regulator in two-component regulatory system with RcsC and YojN) BN373_32431(capsular synthesis regulator component B) t0595(regulator of capsule synthesis B component) SL1344_2239(regulator of capsule synthesis B component) Cluster1031 1 1 1 1 1 1 1 ROD_23491(two-component system response regulator) ENC_39670(Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase./Hpt domain.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1491(Sensor-like histidine kinase RcsD,phosphotransfer intermediate protein in two-component regulatory system with RcsBC,Uncharacterized domain of BarA-like signal transduction histidine kinases,TMAO reductase sytem sensor TorS,Hpt domain) b2216(phosphotransfer intermediate protein in two-component regulatory system with RcsBC) BN373_32421(sensor-like histidine kinase YojN) t0596(putative two-component system sensor kinase) SL1344_2238(putative two-component system sensor kinase) Cluster1032 1 1 1 1 1 1 1 ROD_23471(thiamine biosynthesis lipoprotein) ENC_39700(Membrane-associated lipoprotein involved in thiamine biosynthesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1494(Thiamine biosynthesis lipoprotein ApbE precursor,thiamine biosynthesis lipoprotein ApbE,ApbE family) b2214(predicted thiamine biosynthesis lipoprotein) BN373_32401(thiamine biosynthesis lipoprotein ApbE) t0598(thiamine biosynthesis protein) SL1344_2236(thiamine biosynthesis protein) Cluster1033 1 1 1 1 1 1 1 ROD_23461(regulatory protein of adaptative response [contains: methylated-DNA--protein-cysteine methyltransferase]) ENC_39710(DNA-O6-methylguanine--protein-cysteine S-methyltransferase /Transcriptional regulator Ada) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1495(Regulatory protein of adaptative response,bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase,Methylated DNA-protein cysteine methyltransferase,methylated-DNA-[protein]-cysteine S-methyltransferase,Metal binding domain of Ada) b2213(fused DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase) BN373_32391(regulatory protein Ada) t0599(ADA regulatory protein) SL1344_2235(ADA regulatory protein) Cluster1034 1 1 1 1 1 1 1 ROD_23451(alpha-ketoglutarate-dependent dioxygenase (alkylated DNA repair protein)) ENC_39720(DNA-N1-methyladenine dioxygenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1496(Alpha-ketoglutarate-dependent dioxygenase AlkB,alpha-ketoglutarate-dependent dioxygenase AlkB,Activator of HSP90 ATPase,alkylated DNA repair protein AlkB) b2212(oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions) BN373_32381(alkylated DNA repair protein AlkB) t0600(AlkB protein) SL1344_2234(AlkB protein) Cluster1035 1 1 1 1 1 1 1 ROD_23441(ABC transporter ATP-binding and permease protein) ENC_39730(cyclic peptide transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1497(ABC transporter ATP-binding protein YojI,multidrug transporter membrane component/ATP-binding component,ABC-type siderophore export system, fused ATPase and permease components,cyclic peptide transporter,ABC transporter) b2211(Microcin J25 efflux pump, TolC-dependent; fused ABC transporter permease and ATP-binding components) BN373_32371(cyclic peptide ABC transporter, permease/ATP-binding protein) t0601(putative ABC transporter ATP-binding protein) SL1344_2233(putative ABC transporter ATP-binding protein) Cluster1036 1 1 1 1 1 1 1 ROD_23401(ecotin (serine protease inhibitor)) ENC_39770(Serine protease inhibitor ecotin) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1499(Ecotin precursor,ecotin,Serine protease inhibitor ecotin,Ecotin) b2209(ecotin, a serine protease inhibitor) BN373_32331(ecotin) t0602(ecotin precursor) SL1344_2232(Ecotin precursor) Cluster1037 1 1 1 1 1 1 1 ROD_23201(putative sulphatase) ENC_39800(Predicted hydrolase of alkaline phosphatase superfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1521(Inner membrane protein yejM,arylsulfatase,Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily,choline-sulfatase,Domain of unknown function (DUF3413)) b2188(predicted hydrolase, inner membrane) BN373_32311(sulfatase family protein) t0626(putative sulphatase) SL1344_2205(putative sulphatase) Cluster1038 1 1 1 1 1 1 1 ROD_23191(conserved hypothetical protein) ENC_39810(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1522(hypothetical protein,hypothetical protein,Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF1414)) b2187(conserved protein, UPF0352 family) BN373_32301(conserved hypothetical protein) t0627(conserved hypothetical protein) SL1344_2204(conserved hypothetical protein) Cluster1039 1 1 1 1 1 1 1 ROD_23171(nucleoid-associated protein) ENC_39820(Nucleoid-associated protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1523(Nucleoid-associated protein YejK,nucleoid-associated protein NdpA,37-kD nucleoid-associated bacterial protein) b2186(nucleotide associated protein) BN373_32291(nucleoid-associated protein NdpA) t0628(nucleoid-asociated protein) SL1344_2203(nucleoid-asociated protein) Cluster1040 1 1 1 1 1 1 1 ROD_23161(50S ribosomal protein L25) ENC_39830(LSU ribosomal protein L25P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1524(50S ribosomal protein L25,50S ribosomal protein L25,ribosomal protein L25, Ctc-form,Ribosomal L25p family) b2185(50S ribosomal subunit protein L25) BN373_32241(ribosomal L25p family) t0630(50S ribosomal protein L25) SL1344_2201(50s ribosomal protein L25) Cluster1041 1 1 1 1 1 1 1 ROD_23151(putative helicase) ENC_39840(DNA or RNA helicases of superfamily II) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1525(type I restriction enzyme EcoKI subunit R,Predicted HKD family nuclease,DNA phosphorothioation system restriction enzyme,Type III restriction enzyme, res subunit) b2184(predicted ATP-dependent DNA or RNA helicase) BN373_32231(putative helicase) t0631(putative helicase) SL1344_2200(putative helicase) Cluster1042 1 1 1 1 1 1 1 ROD_23141(ribosomal small subunit pseudouridine synthase A) ENC_39850(ribosomal small subunit pseudouridine synthase A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1526(Ribosomal small subunit pseudouridine synthase A,16S rRNA pseudouridylate synthase A,pseudouridine synthase,RNA pseudouridylate synthase) b2183(16S rRNA U516 pseudouridine synthase) BN373_32221(ribosomal small subunit pseudouridine synthase A) t0632(ribosomal small subunit pseudouridine synthase) SL1344_2199(ribosomal small subunit pseudouridine synthase) Cluster1043 1 1 1 1 1 1 1 ROD_23111(ABC-transporter, ATP-binding protein) ENC_39880(ABC-type uncharacterized transport system, duplicated ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1529(Glutathione import ATP-binding protein GsiA,microcin C ABC transporter ATP-binding protein YejF,ABC-type oligopeptide transport system, ATPase component,nickel import ATP-binding protein NikD,ABC transporter) b2180(microcin C transporter, ATP-binding subunit; ABC family) BN373_32191(ABC transporter, ATP-binding protein) t0636(putative ABC transporter ATP-binding protein) SL1344_2196(putative ABC-transporter ATP-binding protein) Cluster1044 1 1 1 1 1 1 1 ROD_23101(ABC transporter, permease protein) ENC_39890(ABC-type uncharacterized transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1530(Inner membrane ABC transporter permease protein yejE,microcin C ABC transporter permease,ABC-type antimicrobial peptide transport system, permease component,nickel ABC transporter, permease subunit NikC,Binding-protein-dependent transport system inner membrane component) b2179(microcin C transporter YejABEF, permease subunit; ABC family) BN373_32181(ABC transporter, permease protein) t0637(putative binding-protein-dependent transporter) SL1344_2195(putative binding-protein-dependent transporter) Cluster1045 1 1 1 1 1 1 1 ROD_23091(ABC transporter, permease protein) ENC_39900(ABC-type uncharacterized transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1531(Inner membrane ABC transporter permease protein yejB,microcin C ABC transporter permease YejB,nickel ABC transporter, permease subunit NikB,Binding-protein-dependent transport system inner membrane component) b2178(microcin C transporter YejABEF, permease subunit; ABC family) BN373_32171(ABC transporter, permease protein) t0638(putative binding-protein-dependent transporter) SL1344_2194(putative binding-protein-dependent transporter) Cluster1046 1 1 1 1 1 1 1 ROD_23071(putative signal transduction protein) ENC_39930(FOG: EAL domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1533(hypothetical protein,phage resistance protein,Predicted signal transduction protein containing sensor and EAL domains,EAL domain) b2176(resistance protein for phages lambda and N4, when overexpressed) BN373_32151(putative cyclic diguanylate phosphodiesterase) t0640(Rtn protein) SL1344_2192(rtn protein) Cluster1047 1 1 1 1 1 1 1 ROD_23061(lipoprotein) ENC_39940(spr peptidase. Cysteine peptidase. MEROPS family C40) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1534(Probable endopeptidase Spr precursor,outer membrane lipoprotein,Uncharacterized protein conserved in bacteria,putative phage cell wall peptidase, NlpC/P60 family,NlpC/P60 family) b2175(mutational suppressor of prc thermosensitivity, outer membrane lipoprotein) BN373_32141(lipoprotein Spr) t0641(putative lipoprotein) SL1344_2191(putative lipoprotein) Cluster1048 1 1 1 1 1 1 1 ROD_23051(putative membrane protein) ENC_39960(PAP2 superfamily.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1535(Inner membrane protein yeiU,undecaprenyl pyrophosphate phosphatase,PAP2 (acid phosphatase) superfamily protein,PAP2 superfamily) b2174(Lipid A 1-diphosphate synthase; undecaprenyl pyrophosphate:lipid A 1-phosphate phosphotransferase) BN373_32131(PAP2 family protein) t0642(putative membrane protein) SL1344_2190(putative membrane protein) Cluster1049 1 1 1 1 1 1 1 ROD_23021(D-mannonate hydrolase) ENC_40010(D-mannonate dehydratase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4075(Mannonate dehydratase,mannonate dehydratase,mannonate dehydratase,D-mannonate dehydratase (UxuA)) b4322(mannonate hydrolase) BN373_32101(mannonate dehydratase) t3056(D-mannonate hydrolase) SL1344_3109(D-mannonate hydrolase) Cluster1050 1 1 1 1 1 1 1 ROD_22961(multiphosphoryl transfer protein [includes: phosphocarrier protein Hpr; fructose-specific PTS system EIIA component]) ENC_40040(Phosphocarrier protein HPr/PTS system D-fructose-specific IIA component (F1P-forming), Frc family (TC 4.A.2.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1541(Pseudo-HPr,bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein,Uncharacterized protein conserved in bacteria,phosphocarrier, HPr family,Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2) b2169(fused fructose-specific PTS enzymes: IIA component/HPr component) BN373_32041(PTS system fructose-specific phosphotransferase enzyme IIA component) t0650(fructose-specific IIA/FPR component of PTS system) SL1344_2183(pts system, fructose-specific IIA/FPR component) Cluster1051 1 1 1 1 1 1 1 ROD_22951(1-phosphofructokinase) ENC_40050(1-phosphofructokinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1542(Tagatose-6-phosphate kinase,1-phosphofructokinase,ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase,1-phosphofructokinase,pfkB family carbohydrate kinase) b2168(fructose-1-phosphate kinase) BN373_32031(1-phosphofructokinase) t0649(1-phosphofructokinase) SL1344_2182(1-phosphofructokinase) Cluster1052 1 1 1 1 1 1 1 ROD_22871(putative outer membrane protein) ENC_40090(conserved hypothetical integral membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1551(hypothetical protein,conserved hypothetical protein,Conserved hypothetical protein 698) b2158(inner membrane protein, UPF0324 family) BN373_32001(putative membrane protein) t0653(putative membrane protein) SL1344_2179(putative membrane protein) Cluster1053 1 1 1 1 1 1 1 ROD_22861(LysR-family transcriptional regulator) ENC_40100(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1552(CysJI operon transcriptional activator,putative DNA-binding transcriptional regulator,ABC-type phosphate/phosphonate transport system, ATPase component,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b2157(predicted DNA-binding transcriptional regulator) BN373_31991(transcriptional regulator, LysR family) t0654(putative transcriptional regulator) SL1344_2178(putative transcriptional regulator) Cluster1054 1 1 1 1 1 1 1 ROD_22851(lysine-specific permease) ENC_40110(Amino acid transporters) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1553(Lysine-specific permease,lysine transporter,Amino acid transporters,amino acid permease (yeast),Amino acid permease) b2156(lysine transporter) BN373_31981(lysine-specific permease) t0655(lysine-specific permease) SL1344_2177(lysine-specific permease) Cluster1055 1 1 1 1 1 1 1 ROD_22831(colicin I TonB-dependent receptor) ENC_40120(Outer membrane receptor for ferrienterochelin and colicins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1554(Colicin I receptor precursor,catecholate siderophore receptor CirA,Outer membrane receptor for ferrienterochelin and colicins,TonB-dependent vitamin B12 receptor,TonB dependent receptor) b2155(catecholate siderophore receptor CirA) BN373_31951(colicin I receptor) t0656(colicin I receptor precursor) SL1344_2176(colicin I receptor precursor) Cluster1056 1 1 1 1 1 1 1 ROD_22821(putative esterase) ENC_40130(S-formylglutathione hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1555(S-formylglutathione hydrolase yeiG,Predicted hydrolase of the alpha/beta superfamily,S-formylglutathione hydrolase,Putative esterase) b2154(S-formylglutathione hydrolase) BN373_31941(S-formylglutathione hydrolase) t0661(putative esterase) SL1344_2171(putative esterase) Cluster1057 1 1 1 1 1 1 1 ROD_22811(GTP cyclohydrolase I) ENC_40160(GTP cyclohydrolase I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1556(GTP cyclohydrolase 1,GTP cyclohydrolase I,GTP cyclohydrolase I,GTP cyclohydrolase I,GTP cyclohydrolase I) b2153(GTP cyclohydrolase I) BN373_31931(GTP cyclohydrolase I) t0662(GTP cyclohydrolase I) SL1344_2170(GTP cyclohydrolase I) Cluster1058 1 1 1 1 1 1 1 ROD_22801(putative outer membrane protein) ENC_40170(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1557(hypothetical protein,Predicted membrane protein,Protein of unknown function (DUF418)) b2152(predicted inner membrane protein) BN373_31921(putative membrane protein) t0663(putative membrane protein) SL1344_2169(putative membrane protein) Cluster1059 1 1 1 1 1 1 1 ROD_22791(mgl repressor and galactose ultrainduction factor) ENC_40180(transcriptional regulator, LacI family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1558(Mgl repressor and galactose ultrainduction factor,DNA-binding transcriptional regulator GalS,ABC-type sugar transport system, periplasmic component,catabolite control protein A,Bacterial regulatory proteins, lacI family) b2151(DNA-binding transcriptional repressor) BN373_31911(transcriptional regulator GalS) t0664(mgl repressor and galactose ultrainduction factor) SL1344_2168(mgl repressor and galactose ultrainduction factor) Cluster1060 1 1 1 1 1 1 1 ROD_22771(D-galactose ABC transporter, substrate-binding protein) ENC_40190(glucose-binding protein/galactose-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1559(D-galactose/ D-glucose-binding protein,methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB,ABC-type sugar transport system, periplasmic component,D-xylose ABC transporter, D-xylose-binding protein,Periplasmic binding proteins and sugar binding domain of LacI family) b2150(methyl-galactoside transporter subunit) BN373_31901(galactose ABC transporter, periplasmic galactose-binding protein) t0665(D-galactose-binding periplasmic protein precursor) SL1344_2167(D-galactose-binding periplasmic protein precursor) Cluster1061 1 1 1 1 1 1 1 ROD_22751(galactoside ABC transporter, permease protein) ENC_40210(glucose ABC transporter membrane protein/galactose ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1561(Galactoside transport system permease protein mglC,beta-methylgalactoside transporter inner membrane component,ABC-type glucose/galactose transport system, permease component,Branched-chain amino acid transport system / permease component) b2148(methyl-galactoside transporter subunit) BN373_31881(galactose ABC transporter, permease protein) t0667(galactoside transport system permease protein MglC) SL1344_2165(galactoside transport system permease protein MglC) Cluster1062 1 1 1 1 1 1 1 ROD_22701(putative membrane protein) ENC_40230(conserved hypothetical protein TIGR00659) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1567(Inner membrane protein yohK,hypothetical protein,Cytidylyltransferase,conserved hypothetical protein,LrgB-like family) b2142(inner membrane protein, LrgB family) BN373_31851(LrgB family protein) t0673(puatative membrane protein) SL1344_2159(puatative membrane protein) Cluster1063 1 1 1 1 1 1 1 ROD_22691(putative membrane protein) ENC_40240(Putative effector of murein hydrolase LrgA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1568(hypothetical protein,hypothetical protein,Putative effector of murein hydrolase LrgA,LrgA family) b2141(inner membrane protein, UPF0299 family) BN373_31841(LrgA family protein) t0674(putative membrane protein) SL1344_2158(putative membrane protein) Cluster1064 1 1 1 1 1 1 1 pseudoROD_22621(tRNA dihydrouridine synthase C (pseudogene)) ENC_40250(tRNA-U20a,U20b-dihydrouridine synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1569(Probable tRNA-dihydrouridine synthase,tRNA-dihydrouridine synthase C,tRNA-dihydrouridine synthase,putative TIM-barrel protein, nifR3 family,Dihydrouridine synthase (Dus)) b2140(tRNA-dihydrouridine synthase C) BN373_31831(tRNA-dihydrouridine synthase C) t0681(conserved hypothetical protein) SL1344_2151(conserved hypothetical protein) Cluster1065 1 1 1 2 2 0 0 ROD_30981(6-phospho-beta-glucosidase) ENC_29690(6-phospho-beta-glucosidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4798(Aryl-phospho-beta-D-glucosidase BglH,cryptic 6-phospho-beta-glucosidase,Beta-xylosidase,beta-galactosida se,Glycosyl hydrolase family 1) b2716(cryptic 6-phospho-beta-glucosidase),b3721(cryptic phospho-beta-glucosidase B) BN373_31791(6-phospho-beta-glucosidase BglB),BN373_36851(6-phospho-beta-glucosidase) Cluster1066 1 1 1 1 1 1 1 ROD_22591(putative membrane protein) ENC_40300(Uncharacterized membrane-associated protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1572(Inner membrane protein yohD,hypothetical protein,SNARE associated Golgi protein) b2136(inner membrane protein, DedA family) BN373_31771(putative membrane protein) t0685(putative membrane protein) SL1344_2148(putative membrane protein) Cluster1067 1 1 1 1 1 1 1 ROD_22581(putative membrane protein) ENC_40310(Protein of unknown function (DUF1282).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1573(Inner membrane protein yohC,Protein of unknown function (DUF1282)) b2135(inner membrane protein, Yip1 family) BN373_31761(putative membrane protein) t0686(putative membrane protein) SL1344_2147(putative membrane protein) Cluster1068 1 1 1 1 1 1 1 ROD_22521(D-lactate dehydrogenase) ENC_40340(D-lactate dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1575(D-lactate dehydrogenase,D-lactate dehydrogenase,D-lactate dehydrogenase, membrane binding) b2133(D-lactate dehydrogenase, FAD-binding, NADH independent) BN373_31731(D-lactate dehydrogenase) t0688(D-lactate dehydrogenase) SL1344_2145(D-lactate dehydrogenase) Cluster1069 1 1 1 1 1 1 1 ROD_22511(periplasmic beta-glucosidase) ENC_40350(beta-glucosidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1576(Periplasmic beta-glucosidase precursor,beta-D-glucoside glucohydrolase,Glycosyl hydrolase family 3 C terminal domain) b2132(beta-D-glucoside glucohydrolase, periplasmic) BN373_31721(beta-glucosidase, periplasmic) t0689(periplasmic beta-glucosidase precursor) SL1344_2144(periplasmic beta-glucosidase precursor) Cluster1070 1 1 1 1 1 1 1 ROD_22441(ABC transporter, substrate-binding protein) ENC_40360(Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1577(Osmoprotectant-binding protein,ABC-type proline/glycine betaine transport systems, periplasmic components,Substrate binding domain of ABC-type glycine betaine transport system) b2131(predicted transporter subunit: periplasmic-binding component of ABC superfamily) BN373_31711(ABC transporter, quaternary amine uptake transporter (QAT) family, substrate-binding protein) t0690(putative periplasmic protein) SL1344_2143(putative periplasmic protein) Cluster1071 1 1 1 1 1 1 1 ROD_22421(ABC transporter, ATP-binding protein) ENC_40390(ABC-type proline/glycine betaine transport systems, ATPase components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1579(Glycine betaine/L-proline transport ATP-binding protein ProV,putrescine/spermidine ABC transporter ATPase protein,ABC-type proline/glycine betaine transport system, ATPase component,glycine betaine/L-proline transport ATP binding subunit,ABC transporter) b2129(predicted transporter subunit: ATP-binding component of ABC superfamily) BN373_31691(ABC transporter, quaternary amine uptake transporter (QAT) family, ATP-binding protein) t0691(ABC transporter ATP-binding protein) SL1344_2141(ABC transporter ATP-binding protein) Cluster1072 1 1 1 1 1 1 1 ROD_22391(two-component system sensor kinase) ENC_40420(Putative regulator of cell autolysis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1583(Probable sensor-like histidine kinase YehU,Predicted signal transduction protein with a C-terminal ATPase domain,5TMR of 5TMR-LYT) b2126(predicted sensory kinase in two-component system with YehT, inner membrane protein) BN373_31661(sensor histidine kinase) t0696(putative two-component system sensor kinase) SL1344_2137(putative two-component system sensor kinase) Cluster1073 1 1 1 1 1 1 1 ROD_22381(two-component system response regulator) ENC_40430(Response regulator of the LytR/AlgR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1584(Probable transcriptional regulatory protein YehT,putative two-component response-regulatory protein YehT,Response regulator of the LytR/AlgR family,sporulation transcription factor Spo0A,Response regulator receiver domain) b2125(predicted response regulator in two-component system withYehU) BN373_31651(DNA-binding response regulator) t0697(putative two-component system response regulator) SL1344_2136(putative two-component system response regulator) Cluster1074 1 1 1 1 1 1 1 ROD_22371(conserved hypothetical protein) ENC_40440(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1585(Protein of unknown function (DUF1456)) b2124(conserved protein, DUF1456 family) BN373_31641(conserved hypothetical protein) t0698(conserved hypothetical protein) SL1344_2135(conserved hypothetical protein) Cluster1075 1 1 1 1 1 1 1 ROD_22361(Methionyl-tRNA synthetase) ENC_40450(methionyl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1596(Methionine--tRNA ligase,methionyl-tRNA synthetase,Methionyl-tRNA synthetase,methionine--tRNA ligase,tRNA synthetases class I (M)) b2114(methionyl-tRNA synthetase) BN373_31631(methionyl-tRNA synthetase) t0701(methionyl-tRNA synthetase) SL1344_2132(Methionyl-tRNA synthetase) Cluster1076 1 1 1 1 1 1 1 ROD_22351(conserved hypothetical protein) ENC_40460(ATPases involved in chromosome partitioning) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1597(Cell division inhibitor MinD,antiporter inner membrane protein,Septum formation inhibitor-activating ATPase,cell division ATPase MinD,ParA/MinD ATPase like) b2113(antiporter inner membrane protein) BN373_31621(mrp protein) t0702(conserved hypothetical protein) SL1344_2131(conserved hypothetical protein) Cluster1077 1 1 1 1 1 1 1 ROD_22301(putative exported protein) ENC_40480(Domain of unknown function (DUF3315).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1606(Nickel/cobalt homeostasis protein RcnB precursor,Predicted integral membrane protein,Domain of unknown function (DUF3315)) b2107(periplasmic modulator of Ni and Co efflux) BN373_31601(conserved hypothetical protein) t0708(conserved hypothetical protein) SL1344_2125(conserved hypothetical protein) Cluster1078 1 1 1 1 1 1 1 ROD_22281(hydroxyethylthiazole kinase) ENC_40590(hydroxyethylthiazole kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1610(Hydroxyethylthiazole kinase,hydroxyethylthiazole kinase,Thiamine monophosphate synthase,hydroxyethylthiazole kinase,Hydroxyethylthiazole kinase family) b2104(hydoxyethylthiazole kinase) BN373_31541(hydroxyethylthiazole kinase) t0709(hydroxyethylthiazole kinase) SL1344_2124(Hydroxyethylthiazole kinase) Cluster1079 1 1 1 1 1 1 1 ROD_22221(fructose-bisphosphate aldolase class 1) ENC_40640(fructose-bisphosphate aldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1617(Fructose-bisphosphate aldolase class 1,fructose-bisphosphate aldolase,predicted phospho-2-dehydro-3-deoxyheptonate aldolase,DeoC/LacD family aldolase) b2097(fructose-bisphosphate aldolase class I) BN373_31521(fructose-bisphosphate aldolase, class 1) t0715(fructose-bisphosphate aldolase class I) SL1344_2118(fructose-bisphosphate aldolase class I) Cluster1080 1 1 1 1 1 1 1 ROD_22131(putative protease) ENC_40850(Collagenase and related proteases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1629(Uncharacterized protease yhbU precursor,putative protease,Collagenase and related proteases,Peptidase family U32) b2081(predicted peptidase) BN373_31351(peptidase, U32 family) t0720(putative protease) SL1344_2112(putative protease) Cluster1081 1 1 1 1 1 1 1 ROD_22111(two-component response regulator) ENC_40880(Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1631(Transcriptional regulatory protein BaeR,DNA-binding transcriptional regulator BaeR,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain) b2079(DNA-binding response regulator in two-component regulatory system with BaeS) BN373_31341(transcriptional regulatory protein BaeR) t0741(putative two-component system response regulator) SL1344_2108(putative two-component system response regulator) Cluster1082 1 1 1 1 1 1 1 ROD_22101(two-component sensor kinase) ENC_40890(Signal transduction histidine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1632(Signal transduction histidine-protein kinase BaeS,signal transduction histidine-protein kinase BaeS,Signal transduction histidine kinase regulating C4-dicarboxylate transport system,phosphate regulon sensor kinase PhoR,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b2078(sensory histidine kinase in two-component regulatory system with BaeR) BN373_31331(signal transduction histidine-protein kinase BaeS) t0742(putative two-component system sensor kinase) SL1344_2107(putative two-component system sensor kinase) Cluster1083 1 1 1 1 1 1 1 ROD_22091(putative multidrug resistance protein) ENC_40900(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1633(Putative multidrug resistance protein MdtD,putative transporter,Arabinose efflux permease,drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family,Major Facilitator Superfamily) b2077(predicted transporter with no MDR phenotype when mutated or cloned) BN373_31321(putative multidrug resistance protein MdtD) t0743(putative transporter protein) SL1344_2106(putative transporter protein) Cluster1084 1 1 1 1 1 1 1 ROD_22061(multidrug resistance protein) ENC_40950(RND family efflux transporter, MFP subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1636(Efflux pump periplasmic linker BepF,multidrug efflux system subunit MdtA,efflux transporter, RND family, MFP subunit,HlyD family secretion protein) b2074(multidrug efflux system, subunit A) BN373_31291(multidrug resistance protein MdtA) t0746(putative efflux system protein) SL1344_2103(putative efflux system protein) Cluster1085 1 1 1 1 1 1 1 ROD_22041(DNA-3-methyladenine glycosidase II) ENC_40970(DNA-3-methyladenine glycosylase II) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1643(DNA-3-methyladenine glycosylase 2,3-methyl-adenine DNA glycosylase II,3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase,AlkA N-terminal domain) b2068(3-methyl-adenine DNA glycosylase II) BN373_31231(DNA-3-methyladenine glycosylase 2) t0748(DNA-3-methyladenine glycosidase II) SL1344_2101(DNA-3-methyladenine glycosidase II) Cluster1086 1 1 1 1 1 1 1 ROD_22021(uridine kinase) ENC_41010(uridine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1645(Uridine kinase,uridine/cytidine kinase,uridine kinase,Phosphoribulokinase / Uridine kinase family) b2066(uridine/cytidine kinase) BN373_31221(uridine kinase) t0750(uridine kinase) SL1344_2099(Uridine kinase) Cluster1087 1 1 1 1 1 1 1 ROD_22011(deoxycytidine triphosphate deaminase) ENC_41020(dCTP deaminase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1646(Deoxycytidine triphosphate deaminase,deoxycytidine triphosphate deaminase,deoxycytidine triphosphate deaminase,2'-deoxycytidine 5'-triphosphate deaminase (DCD)) b2065(2'-deoxycytidine 5'-triphosphate deaminase) BN373_31211(deoxycytidine triphosphate deaminase) t0751(deoxycytidine triphosphate deaminase) SL1344_2098(deoxycytidine triphosphate deaminase) Cluster1088 1 1 1 1 1 1 1 ROD_22001(putative outer membrane assembly protein) ENC_41030(Uncharacterized protein involved in outer membrane biogenesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1647(putative assembly protein,Uncharacterized protein involved in outer membrane biogenesis,AsmA family) b2064(predicted assembly protein) BN373_31201(AsmA protein) t0752(putative outer membrane assembly protein) SL1344_2097(putative outer membrane assembly protein) Cluster1089 1 1 1 1 1 1 1 ROD_21991(putative transport protein) ENC_41040(Membrane protein TerC, possibly involved in tellurium resistance) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1648(hypothetical protein,magnesium/cobalt efflux protein CorC,Putative Mg2+ and Co2+ transporter CorB,gliding motility-associated protein GldE,Integral membrane protein TerC family) b2063(inner membrane protein) BN373_31191(membrane protein, TerC family/CBS/transporter associated domain protein) t0753(putative membrane protein) SL1344_2096(putative membrane protein) Cluster1090 1 1 1 1 1 1 1 ROD_21781(UTP-glucose-1-phosphate uridylyltransferase) ENC_41240(UDP-glucose pyrophosphorylase regulatory subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1670(UTP--glucose-1-phosphate uridylyltransferase,GalU regulator GalF,CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes,regulatory protein GalF,Nucleotidyl transferase) b2042(putative regulatory subunit for GalU) BN373_31181(UTP--glucose-1-phosphate uridylyltransferase) t0774(UTP-glucose-1-phosphate uridylyltransferase) SL1344_2075(UTP-glucose-1-phosphate uridylyltransferase) Cluster1091 1 1 1 1 1 1 1 ROD_21821(putative flippase) ENC_41200(Membrane protein involved in the export of O-antigen and teichoic acid) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1666(Lipopolysaccharide biosynthesis protein wzxC,colanic acid exporter,Polysaccharide biosynthesis protein) b2046(predicted colanic acid exporter) BN373_31081(colanic acid exporter) t0770(putative transmembrane transport protein) SL1344_2079(putative transmembrane transport protein) Cluster1092 1 1 1 1 1 1 1 ROD_21831(putative colanic biosynthesis UDP-glucose lipid carrier transferase) ENC_41190(Undecaprenyl-phosphate glucose phosphotransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1665(Putative colanic biosynthesis UDP-glucose lipid carrier transferase,putative UDP-glucose lipid carrier transferase,undecaprenyl-phosphate glucose phosphotransferase,Bacterial sugar transferase) b2047(predicted UDP-glucose lipid carrier transferase) BN373_31051(putative UDP-glucose lipid carrier transferase) t0769(putative extracellular polysaccharide biosynthesis protein) SL1344_2080(putative extracellular polysaccharide biosynthesis protein) Cluster1093 1 1 1 1 1 1 1 ROD_21671(6-phosphogluconate dehydrogenase, decarboxylating) ENC_41380(6-phosphogluconate dehydrogenase (decarboxylating)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1683(6-phosphogluconate dehydrogenase, decarboxylating,6-phosphogluconate dehydrogenase,Gluconate kinase,6-phosphogluconate dehydrogenase (decarboxylating),6-phosphogluconate dehydrogenase, C-terminal domain) b2029(6-phosphogluconate dehydrogenase, decarboxylating) BN373_31041(6-phosphogluconate dehydrogenase, decarboxylating) t0792(6-phosphogluconate dehydrogenase, decarboxylating) SL1344_2058(6-phosphogluconate dehydrogenase, decarboxylating) Cluster1094 1 1 1 1 1 1 1 ROD_21841(phosphomannomutase) ENC_41370(phosphomannomutase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1664(Phosphomannomutase/phosphoglucomutase,phosphomann omutase CpsG,phosphoglucosamine mutase,Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I) b2048(phosphomannomutase) BN373_31001(phosphomannomutase) t0768(phosphomannomutase) SL1344_2081(phosphomannomutase) Cluster1095 1 1 1 1 1 1 1 ROD_21641(histidine biosynthesis bifunctional protein) ENC_41430(phosphoribosyl-ATP pyrophosphatase /phosphoribosyl-AMP cyclohydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1686(Phosphoribosyl-ATP pyrophosphatase,bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein,Phosphoribosyl-AMP cyclohydrolase,phosphoribosyl-ATP diphosphatase,Phosphoribosyl-AMP cyclohydrolase) b2026(fused phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase) BN373_30851(phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase) t0795(phosphoribosyl-AMP cyclohydrolase) SL1344_2055(bifunctional histidine biosynthesis bifunctional protein (phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase)) Cluster1096 1 1 1 1 1 1 1 ROD_21631(imidazole glycerol phosphate synthase subunit) ENC_41440(imidazole glycerol phosphate synthase subunit hisF) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1687(Imidazole glycerol phosphate synthase subunit HisF,imidazole glycerol phosphate synthase subunit HisF,Imidazoleglycerol-phosphate synthase,imidazoleglycerol phosphate synthase, cyclase subunit,Histidine biosynthesis protein) b2025(imidazole glycerol phosphate synthase, catalytic subunit with HisH) BN373_30841(imidazoleglycerol phosphate synthase, cyclase subunit) t0796(cyclase HisF) SL1344_2054(Imidazole glycerol phosphate synthase subunit hisF) Cluster1097 1 1 1 1 1 1 1 ROD_21621(1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino imidazole-4-carboxamide isomerase) ENC_41450(1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylidenea mino] imidazole-4-carboxamide isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1688(1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino] imidazole-4-carboxamide isomerase,1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino] imidazole-4-carboxamide isomerase,Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase,1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino]imidazole-4-carboxamide isomerase,Histidine biosynthesis protein) b2024(N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'-phosphoribosyl)-4-imidazolecarboxamide isomerase) BN373_30831(phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase) t0797(phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase) SL1344_2053(1-) Cluster1098 1 1 1 1 1 1 1 ROD_21611(imidazole glycerol phosphate synthase subunit) ENC_41460(imidazole glycerol phosphate synthase subunit hisH) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1689(Imidazole glycerol phosphate synthase subunit HisH,imidazole glycerol phosphate synthase subunit HisH,Imidazoleglycerol-phosphate synthase,imidazole glycerol phosphate synthase, glutamine amidotransferase subunit,Glutamine amidotransferase class-I) b2023(imidazole glycerol phosphate synthase, glutamine amidotransferase subunit with HisF) BN373_30821(imidazole glycerol phosphate synthase, glutamine amidotransferase subunit) t0798(amidotransferase) SL1344_2052(Imidazole glycerol phosphate synthase subunit hisH) Cluster1099 1 1 1 1 1 1 1 ROD_21601(histidine biosynthesis bifunctional protein includes histidinol-phosphatase; imidazoleglycerol-phosphat dehydratase]) ENC_41470(imidazoleglycerol-phosphate dehydratase /histidinol-phosphate phosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1690(Histidine biosynthesis bifunctional protein hisB,imidazole glycerol-phosphate dehydratase/histidinol phosphatase,Imidazoleglycerol-phosphate dehydratase,histidinol-phosphatase,Imidazoleglycerol-phosph ate dehydratase) b2022(fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase) BN373_30811(histidinol-phosphatase/imidazoleglycerol-phosph ate dehydratase) t0799(imidazoleglycerol-phosphate dehydratase) SL1344_2051(bifunctional histidine biosynthesis protein (imidazoleglycerol-phosphate dehydratase; histidinol phosphatase)) Cluster1100 1 1 1 1 1 1 1 ROD_21591(histidinol-phosphate aminotransferase) ENC_41480(histidinol phosphate aminotransferase apoenzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1691(Histidinol-phosphate aminotransferase,histidinol-phosphate aminotransferase,Histidinol dehydrogenase,histidinol-phosphate transaminase,Aminotransferase class I and II) b2021(histidinol-phosphate aminotransferase) BN373_30801(histidinol-phosphate aminotransferase) t0800(histidinol-phosphate aminotransferase) SL1344_2050(histidinol-phosphate aminotransferase (imidazole)) Cluster1101 1 1 1 1 1 1 1 ROD_21581(histidinol dehydrogenase) ENC_41490(histidinol dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1692(Histidinol dehydrogenase,bifunctional histidinal dehydrogenase/ histidinol dehydrogenase,Histidinol dehydrogenase,histidinol dehydrogenase,Histidinol dehydrogenase) b2020(bifunctional histidinal dehydrogenase/ histidinol dehydrogenase) BN373_30791(histidinol dehydrogenase) t0801(histidinol dehydrogenase) SL1344_2049(histidinol dehydrogenase) Cluster1102 1 1 1 1 1 1 1 ROD_21571(ATP phosphoribosyltransferase) ENC_41500(ATP phosphoribosyltransferase (homohexameric)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1693(ATP phosphoribosyltransferase,ATP phosphoribosyltransferase,ATP phosphoribosyltransferase,ATP phosphoribosyltransferase,ATP phosphoribosyltransferase) b2019(ATP phosphoribosyltransferase) BN373_30781(ATP phosphoribosyltransferase) t0802(ATP phosphoribosyltransferase) SL1344_2048(ATP phosphoribosyltransferase) Cluster1103 1 1 1 1 1 1 1 ROD_21561(putative exported protein) ENC_41520(Nucleoside-diphosphate-sugar epimerases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1697(hypothetical protein,nucleotide sugar dehydrogenase,NAD dependent epimerase/dehydratase family) b2016(predicted epimerase, with NAD(P)-binding Rossmann-fold domain) BN373_30761(NAD dependent epimerase/dehydratase family protein) t0804(conserved hypothetical protein) SL1344_2047(conserved hypothetical protein) Cluster1104 1 1 1 1 1 1 1 ROD_21551(LysR-family transcriptional regulator) ENC_41530(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1698(HTH-type transcriptional activator AllS,putative DNA-binding transcriptional regulator,pca operon transcription factor PcaQ,LysR substrate binding domain) b2015(predicted DNA-binding transcriptional regulator) BN373_30751(transcriptional regulator, LysR family) t0805(putative transcriptional regulator) SL1344_2046(putative transcriptional regulator) Cluster1105 1 1 1 1 1 1 1 ROD_21501(exodeoxyribonuclease I) ENC_41550(Exodeoxyribonuclease I subunit C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1703(Exodeoxyribonuclease I,exonuclease I,Exonuclease C-terminal) b2011(exonuclease I) BN373_30711(exodeoxyribonuclease I) t0807(exodeoxyribonuclease I) SL1344_2044(exodeoxyribonuclease I) Cluster1106 1 1 1 1 1 1 1 ROD_21481(DNA gyrase inhibitory protein) ENC_41570(DNA gyrase inhibitor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1705(DNA gyrase inhibitor,DNA gyrase inhibitor,DNA gyrase inhibitor,Bacterial transcription activator, effector binding domain) b2009(DNA gyrase inhibitor) BN373_30691(DNA gyrase inhibitory protein) t0813(putative DNA gyrase inhibitory protein) SL1344_2037(putative DNA gyrase inhibitory protein) Cluster1107 1 1 1 1 1 1 1 pseudoROD_21471(putative membrane protein (pseudogene)) ENC_24920(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1706(Inner membrane protein yeeA,Fusaric acid resistance protein family) b2008(inner membrane protein, FUSC family) BN373_30681(putative membrane protein) t0814(putative membrane protein) SL1344_2036(putative membrane protein) Cluster1108 1 1 1 1 1 1 1 ROD_21451(conserved hypothetical protein) ENC_24910(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1707(hypothetical protein,hypothetical protein,Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF496)) b2007(conserved protein, UPF0265 family) BN373_30671(conserved hypothetical protein) t0815(conserved hypothetical protein) SL1344_2035(conserved hypothetical protein) Cluster1109 1 1 1 1 1 1 1 ROD_12541(conserved hypothetical protein) ENC_09340(Uncharacterized protein/domain, possibly involved in tellurite resistance) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2084(hypothetical protein,tellurite resistance protein TehB,Uncharacterized protein/domain, possibly involved in tellurite resistance,Domain of unknown function (DUF1971)) b1797(conserved protein) BN373_30561(conserved hypothetical protein) t1149(conserved hypothetical protein) pseudoSL1344_1206(conserved hypothetical protein (pseudogene)) Cluster1110 1 1 1 1 1 1 1 ROD_20951(putative membrane protein) ENC_24890(Na+-driven multidrug efflux pump) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1767(Na(+)/drug antiporter,MATE family multidrug exporter,MATE efflux family protein,MatE) b1985(predicted multdrug exporter, MATE family) BN373_30281(yeeo) t0862(putative inner membrane protein) SL1344_1990(putative inner membrane protein) Cluster1111 1 1 1 1 1 1 1 ROD_20941(AMP nucleosidase) ENC_41600(AMP nucleosidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1770(AMP nucleosidase,AMP nucleosidase,AMP nucleosidase,Bacterial AMP nucleoside phosphorylase N-terminus) b1982(AMP nucleosidase) BN373_30271(AMP nucleosidase) t0868(AMP nucleosidase) SL1344_1986(AMP nucleosidase) Cluster1112 1 1 1 1 1 1 1 ROD_45631(putative zinc-binding dehydrogenase) ENC_34990(putative quinone oxidoreductase, YhdH/YhfP family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.448(Putative quinone oxidoreductase YhdH,putative alcohol dehydrogenase,putative quinone oxidoreductase, YhdH/YhfP family,Zinc-binding dehydrogenase) b3253(predicted oxidoreductase, Zn-dependent and NAD(P)-binding) BN373_30231(quinone oxidoreductase, YhdH family) t3291(possible oxidoreductase) SL1344_3349(possible oxidoreductase) Cluster1113 1 1 1 1 1 1 1 ROD_21001(putative exported protein) ENC_41710(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1762(Probable L,D-transpeptidase ErfK/SrfK precursor,L,D-transpeptidase,L,D-transpeptidase catalytic domain) b1990(L,D-transpeptidase linking Lpp to murein) BN373_30181(ErfK/YbiS/YcfS/YnhG family protein) t0859(putative exported protein) SL1344_1991(putative exported protein) Cluster1114 1 1 1 1 1 1 1 ROD_20631(Conserved hypothetical protein) ENC_41880(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1789(Mlc titration factor A,DgsA anti-repressor MtfA,Phosphoenolpyruvate:glucose-phosphotransferase regulator) b1976(anti-repressor for DgsA(Mlc)) BN373_30151(Mlc titration factor MtfA) t0877(conserved hypothetical protein) SL1344_1977(conserved hypothetical protein) Cluster1115 1 1 1 1 1 1 1 ROD_20411(putative phosphohydrolase) ENC_42020(Predicted HD superfamily hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1861(hypothetical protein,putative hydrolase,Predicted HD superfamily hydrolase,HD domain) b1962(predicted hydrolase, HD superfamily) BN373_30121(putative metal-dependent phosphohydrolase) t0885(conserved hypothetical protein) SL1344_1921(conserved hypothetical protein) Cluster1116 1 1 1 1 1 1 1 ROD_20401(DNA-cytosine methyltransferase) ENC_42030(DNA-methyltransferase (dcm)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1862(DNA-cytosine methyltransferase,DNA cytosine methylase,DNA (cytosine-5-)-methyltransferase,C-5 cytosine-specific DNA methylase) b1961(DNA cytosine methyltransferase) BN373_30111(DNA-cytosine methyltransferase) t0886(DNA-cytosine methyltransferase) SL1344_1920(DNA-cytosine methyltransferase) Cluster1117 1 1 1 1 1 1 1 ROD_20381(putative membrane protein) ENC_42060(Carboxylate/Amino Acid/Amine Transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1864(Uncharacterized inner membrane transporter yedA,putative DMT superfamily transporter inner membrane protein,Predicted permease, DMT superfamily,carboxylate/amino acid/amine transporter,EamA-like transporter family) b1959(amino acid exporter for phenylalanine, threonine) BN373_30091(drug/metabolite transporter, DMT family) t0888(putative membrane protein) SL1344_1918(putative membrane protein) Cluster1118 1 1 1 1 1 1 1 ROD_20321(DsrB protein) ENC_42130(Dextransucrase DSRB.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1871(hypothetical protein,Dextransucrase DSRB) b1952(predicted protein) BN373_30051(conserved hypothetical protein) t0894(DsrB protein) SL1344_1912(DsrB protein) Cluster1119 1 1 1 1 1 1 1 ROD_20311(colanic acid capsullar biosynthesis activation protein A) ENC_42140(Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1872(Colanic acid capsular biosynthesis activation protein A,colanic acid capsular biosynthesis activation protein A,Bacterial regulatory proteins, luxR family) b1951(DNA-binding transcriptional activator, co-regulator with RcsB) BN373_30041(transcriptional regulator, LuxR family) t0895(colanic acid capsullar biosynthesis activation protein A) SL1344_1911(colanic acid capsullar biosynthesis activation protein A) Cluster1120 1 1 1 1 1 1 1 ROD_20121(putative lipoprotein) ENC_05470(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1895(lipoprotein) b1928(lipoprotein) BN373_30031(lipoprotein) t0913(putative lipoprotein) SL1344_1893(putative lipoprotein) Cluster1121 1 1 1 1 1 1 1 ROD_20111(cytoplasmic alpha-amylase) ENC_05480(Glycosidases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1896(Alpha-amylase precursor,cytoplasmic alpha-amylase,malto-oligosyltrehalose trehalohydrolase,Alpha amylase, catalytic domain) b1927(cytoplasmic alpha-amylase) BN373_30021(alpha-amylase, cytoplasmic) t0914(cytoplasmic alpha-amylase) SL1344_1892(cytoplasmic alpha-amylase) Cluster1122 1 1 1 1 1 1 1 ROD_19751(cystine-binding periplasmic protein) ENC_05560(L-cystine-binding protein/Diaminopimelate-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1903(Sulfate starvation-induced protein 7,cystine transporter subunit,Response regulator containing a CheY-like receiver domain and a GGDEF domain,lysine-arginine-ornithine-binding periplasmic protein,Bacterial extracellular solute-binding proteins, family 3) b1920(cystine transporter subunit) BN373_30011(cystine ABC transporter, periplasmic cystine-binding protein) t0922(cystine-binding periplasmic protein precursor) SL1344_1883(cystine-binding periplasmic protein (FliY)) Cluster1123 1 1 1 1 1 1 1 ROD_19741(D-cysteine desulfhydrase) ENC_05570(D-cysteine desulfhydrase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1904(D-cysteine desulfhydrase,D-cysteine desulfhydrase,pyridoxal phosphate-dependent enzymes, D-cysteine desulfhydrase family,Pyridoxal-phosphate dependent enzyme) b1919(D-cysteine desulfhydrase, PLP-dependent) BN373_30001(D-cysteine desulfhydrase) t0923(putative deaminase) SL1344_1882(D-cysteine desulfhydrase) Cluster1124 1 1 1 1 1 1 1 ROD_19731(putative cystine ABC transporter, permease protein) ENC_05580(L-cystine ABC transporter membrane protein/Diaminopimelate ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1905(Inner membrane amino-acid ABC transporter permease protein yecS,amino acid ABC transporter permease,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component) b1918(inner membrane protein, predicted transporter subunit: membrane component of ABC superfamily) BN373_29991(amino acid ABC transporter, permease protein) t0924(putative ABC transporter membrane protein) SL1344_1881(putative ABC transporter membrane protein) Cluster1125 1 1 1 1 1 1 1 ROD_19721(putative cystine ABC-transporter, ATP-binding protein) ENC_05590(L-cystine ABC transporter ATP-binding protein/Diaminopimelate ABC transporter ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1906(Arginine transport ATP-binding protein ArtM,putative amino-acid ABC transporter ATP-binding protein YecC,ABC-type histidine transport system, ATPase component,ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA,ABC transporter) b1917(predicted transporter subunit: ATP-binding component of ABC superfamily) BN373_29981(amino acid ABC transporter, ATP-binding protein) t0925(putative ABC transport ATP-binding protein) SL1344_1880(putative ABC-transport ATP-binding protein) Cluster1126 1 1 1 1 1 1 1 ROD_19711(regulatory protein) ENC_05610(transcriptional activator SdiA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1907(Regulatory protein SdiA,DNA-binding transcriptional activator SdiA,ATP-dependent transcriptional regulator,LuxR family transcriptional regulatory, chaperone HchA-associated,Autoinducer binding domain) b1916(quorum-sensing transcriptional activator) BN373_29971(DNA-binding transcriptional activator SdiA) t0926(cell-division regulatory protein) SL1344_1879(cell-division regulatory protein) Cluster1127 1 1 1 1 1 1 1 ROD_19701(conserved hypothetical protein) ENC_05620(Protein of unknown function (DUF2594).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1908(hypothetical protein,Protein of unknown function (DUF2594)) b1915(conserved protein, DUF2594 family) BN373_29961(conserved hypothetical protein) t0927(conserved hypothetical protein) SL1344_1878(conserved hypothetical protein) Cluster1128 1 1 1 1 1 1 1 ROD_19631(conserved hypothetical protein) ENC_05760(yecA family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1976(hypothetical protein,hypothetical protein,Predicted metal-binding protein related to the C-terminal domain of SecA,yecA family protein,Uncharacterised protein family (UPF0149)) b1908(conserved protein, UPF0149 family) BN373_29911(SEC-C domain protein) t0940(conserved hypothetical protein) SL1344_1871(conserved hypothetical protein) Cluster1129 1 1 1 1 1 1 1 ROD_19621(tyrosine-specific transport protein) ENC_05770(aromatic amino acid transport protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1977(Tyrosine permease,tyrosine transporter TyrP,aromatic amino acid transport protein,Tryptophan/tyrosine permease family) b1907(tyrosine transporter) BN373_29901(tyrosine-specific transport protein) t0941(tyrosine-specific transport protein) SL1344_1870(tyrosine-specific transport protein) Cluster1130 1 1 1 1 1 1 1 ROD_19611(conserved hypothetical protein) ENC_05780(Protein of unknown function (DUF2492).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1978(putative metal-binding protein,Protein of unknown function (DUF2492)) b1906(predicted protein) BN373_29891(conserved hypothetical protein) t0942(conserved hypothetical protein) SL1344_1869(conserved hypothetical protein) Cluster1131 1 1 1 1 1 1 1 ROD_19601(ferritin-1) ENC_05790(Ferritin-like protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1979(Ferritin-1,ferritin,Ferritin-like protein,Ferritin-like domain) b1905(ferritin iron storage protein (cytoplasmic)) BN373_29881(ferritin-1) t0943(ferritin) SL1344_1868(ferritin) Cluster1132 1 1 1 1 1 1 1 ROD_19551(ferritin-like protein 2) ENC_05840(Ferritin-like protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1982(Ferritin-1,ferritin-like protein,Ferritin-like protein,Ferritin-like domain) b1902(ferritin B, probable ferrous iron reservoir) BN373_29831(ferritin family protein) t0945(ferritin-like protein) SL1344_1865(ferritin-like protein) Cluster1133 1 1 1 1 1 1 1 ROD_19481(alpha,alpha-trehalose-phosphate synthase [UDP-forming]) ENC_05910(trehalose 6-phosphate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1987(Alpha,alpha-trehalose-phosphate synthase [UDP-forming],trehalose-6-phosphate synthase,Trehalose-6-phosphate synthase,alpha,alpha-trehalose-phosphate synthase (UDP-forming),Glycosyltransferase family 20) b1896(trehalose-6-phosphate synthase) BN373_29781(alpha,alpha-trehalose-phosphate synthase (UDP-forming)) t0949(trehalose-6-phosphate synthase) SL1344_1862(trehalose-6-phosphate synthase) Cluster1134 1 1 1 1 1 1 1 ROD_19471(universal stress protein C) ENC_05920(Universal stress protein UspA and related nucleotide-binding proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1988(Universal stress protein A,universal stress protein UspC,Universal stress protein family) b1895(universal stress protein) BN373_29771(universal stress protein C) t0950(conserved hypothetical protein) SL1344_1861(conserved hypothetical protein) Cluster1135 1 1 1 1 1 1 1 ROD_19191(conserved hypothetical protein) ENC_06200(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2006(hypothetical protein,hypothetical protein,Uncharacterized protein conserved in bacteria,YecM protein) b1875(predicted metal-binding enzyme) BN373_29731(conserved hypothetical protein) t0969(conserved hypothetical protein) SL1344_1843(conserved hypothetical protein) Cluster1136 1 1 1 1 1 1 1 ROD_19171(conserved hypothetical protein) ENC_06220(methyltransferase, putative) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2010(tRNA (mo5U34)-methyltransferase,tRNA mo(5)U34 methyltransferase,tRNA (mo5U34)-methyltransferase,Protein of unknown function (DUF1698)) b1871(tRNA mo(5)U34 methyltransferase, SAM-dependent) BN373_29711(putative methyltransferase) t0971(conserved hypothetical protein) SL1344_1841(conserved hypothetical protein) Cluster1137 1 1 1 1 1 1 1 ROD_19161(conserved hypothetical protein) ENC_06230(methyltransferase, putative) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2011(tRNA (cmo5U34)-methyltransferase,tRNA cmo(5)U34 methyltransferase,Trans-aconitate methyltransferase,tRNA (cmo5U34)-methyltransferase,Methyltransferase domain) b1870(tRNA cmo(5)U34 methyltransferase, SAM-dependent) BN373_29701(putative methyltransferase) t0972(conserved hypothetical protein) SL1344_1840(conserved hypothetical protein) Cluster1138 1 1 1 1 1 1 1 ROD_19151(putative membrane protein) ENC_06240(Uncharacterized relative of glutathione S-transferase, MAPEG superfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2012(Inner membrane protein yecN,Uncharacterized relative of glutathione S-transferase, MAPEG superfamily,MAPEG family) b1869(inner membrane protein, MAPEG family) BN373_29691(putative inner membrane protein) t0973(putative membrane protein) SL1344_1839(putative membrane protein) Cluster1139 1 1 1 1 1 1 1 ROD_19081(putative isochorismatase) ENC_06270(Amidases related to nicotinamidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2014(Isochorismatase family protein yecD,putative hydrolase,pyrimidine utilization protein B,Isochorismatase family) b1867(isochorismatase family protein) BN373_29671(isochorismatase family protein) t0975(putative hydrolase) SL1344_1837(putative hydrolase) Cluster1140 1 1 1 1 1 1 1 ROD_19061(dATP pyrophosphohydrolase) ENC_06300(dihydroneopterin triphosphate pyrophosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2016(Dihydroneopterin triphosphate pyrophosphatase,dihydroneopterin triphosphate pyrophosphatase,NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding,mutator mutT protein,NUDIX domain) b1865(dihydroneopterin triphosphate pyrophosphatase) BN373_29651(dATP pyrophosphohydrolase) t0977(DATP pyrophosphohydrolase) SL1344_1835(DATP pyrophosphohydrolase) Cluster1141 1 1 1 1 1 1 1 ROD_19051(conserved hypothetical protein) ENC_06310(conserved hypothetical protein TIGR01033) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2017(Probable transcriptional regulatory protein YebC,hypothetical protein,DNA-binding regulatory protein, YebC/PmpR family,Domain of unknown function DUF28) b1864(conserved protein, UPF0082 family) BN373_29641(conserved hypothetical protein TIGR01033) t0978(conserved hypothetical protein) SL1344_1834(hypothetical protein) Cluster1142 1 1 1 1 1 1 1 ROD_19041(crossover junction endodeoxyribonuclease) ENC_06320(crossover junction endodeoxyribonuclease RuvC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2018(Crossover junction endodeoxyribonuclease RuvC,Holliday junction resolvase,crossover junction endodeoxyribonuclease RuvC,Crossover junction endodeoxyribonuclease RuvC) b1863(component of RuvABC resolvasome, endonuclease) BN373_29631(crossover junction endodeoxyribonuclease RuvC) t0979(crossover junction endodeoxyribonuclease) SL1344_1833(Crossover junction endodeoxyribonuclease ruvC) Cluster1143 1 1 1 1 1 1 1 ROD_19031(holliday junction ATP-dependent DNA helicase) ENC_06330(Holliday junction DNA helicase subunit RuvA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2020(Holliday junction ATP-dependent DNA helicase RuvA,Holliday junction DNA helicase RuvA,Holliday junction DNA helicase RuvA,RuvA N terminal domain) b1861(component of RuvABC resolvasome, regulatory subunit) BN373_29621(Holliday junction DNA helicase RuvA) t0982(Holliday junction DNA helicase) SL1344_1829(Holliday junction DNA helicase ruvA) Cluster1144 1 1 1 1 1 1 1 ROD_19001(high-affinity zinc uptake system membrane protein) ENC_06360(ABC-type Mn2+/Zn2+ transport systems, permease components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2024(High-affinity zinc uptake system membrane protein znuB,high-affinity zinc transporter membrane component,anchored repeat-type ABC transporter, permease subunit,ABC 3 transport family) b1859(zinc transporter subunit: membrane component of ABC superfamily) BN373_29601(high-affinity zinc uptake ABC transporter, permease protein) t0984(high-affinity zinc uptake system membrane protein) SL1344_1827(high-affinity zinc uptake system membrane protein) Cluster1145 1 1 1 1 1 1 1 ROD_18981(high-affinity zinc uptake system protein) ENC_06380(ABC-type Zn2+ transport system, periplasmic component/surface adhesin) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2026(High-affinity zinc uptake system protein znuA precursor,high-affinity zinc transporter periplasmic component,ABC-type Zn2+ transport system, periplasmic component/surface adhesin,anchored repeat ABC transporter, substrate-binding protein,Periplasmic solute binding protein family) b1857(zinc transporter subunit: periplasmic-binding component of ABC superfamily) BN373_29581(high-affinity zinc uptake ABC transporter, periplasmic zinc-binding protein) t0986(high-affinity zinc uptake system periplasmic binding protein) SL1344_1825(high-affinity zinc uptake system periplasmic binding protein) Cluster1146 1 1 1 1 1 1 1 ROD_18971(putative peptidoglycan-binding peptidase) ENC_06390(Membrane proteins related to metalloendopeptidases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2027(Glycyl-glycine endopeptidase lytM precursor,putative peptidase,Membrane-bound metallopeptidase,Peptidase family M23) b1856(predicted peptidase) BN373_29571(metalloprotease, opacity-associated protein A family) t0987(conserved hypothetical protein) SL1344_1824(conserved hypothetical protein) Cluster1147 1 1 1 1 1 1 1 ROD_18961(lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase) ENC_06400(lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2028(Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase,lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase,Lauroyl/myristoyl acyltransferase,lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase,Bacterial lipid A biosynthesis acyltransferase) b1855(myristoyl-acyl carrier protein (ACP)-dependent acyltransferase) BN373_29561(lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase) t0988(lipid A acyltransferase) SL1344_1823(lipid A acyltransferase) Cluster1148 1 1 1 1 1 1 1 ROD_18941(pyruvate kinase II) ENC_06410(pyruvate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2029(Pyruvate kinase II,pyruvate kinase,pyruvate kinase,Pyruvate kinase, barrel domain) b1854(pyruvate kinase II) BN373_29551(pyruvate kinase II) t0989(pyruvate kinase A) SL1344_1822(pyruvate kinase A) Cluster1149 1 1 1 1 1 1 1 ROD_18931(putative hex-regulon repressor (RpiR-family transcriptional regulator)) ENC_06420(Transcriptional regulators) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2030(Uncharacterized HTH-type transcriptional regulator ybbH,DNA-binding transcriptional regulator HexR,Predicted phosphosugar isomerases,6-phospho 3-hexuloisomerase,Helix-turn-helix domain, rpiR family) b1853(predicted DNA-binding transcriptional regulator) BN373_29541(transcriptional regulator, RpiR family) t0990(putative hex-regulon repressor) SL1344_1821(putative hex-regulon repressor) Cluster1150 1 1 1 1 1 1 1 ROD_18921(glucose 6-phosphate 1-dehydrogenase) ENC_06430(glucose-6-phosphate 1-dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2032(Glucose-6-phosphate 1-dehydrogenase,glucose-6-phosphate 1-dehydrogenase,glucose-6-phosphate dehydrogenase,Glucose-6-phosphate dehydrogenase, C-terminal domain) b1852(glucose-6-phosphate 1-dehydrogenase) BN373_29531(glucose-6-phosphate 1-dehydrogenase) t0991(glucose 6-phosphate dehydrogenase) SL1344_1820(glucose 6-phosphate dehydrogenase) Cluster1151 1 1 1 1 1 1 1 ROD_18911(phosphogluconate dehydratase) ENC_06440(6-phosphogluconate dehydratase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2033(Dihydroxy-acid dehydratase,phosphogluconate dehydratase,Dihydroxyacid dehydratase/phosphogluconate dehydratase,phosphogluconate dehydratase,Dehydratase family) b1851(6-phosphogluconate dehydratase) BN373_29521(phosphogluconate dehydratase) t0992(6-phosphogluconate dehydratase) SL1344_1819(6-phosphogluconate dehydratase) Cluster1152 1 1 1 1 1 1 1 ROD_18901(KHG/KDPG aldolase [includes: 4-hydroxy-2-oxoglutarate aldolase; 2 dehydro-3-deoxy-phosphogluconate aldolase]) ENC_06450(2-keto-3-deoxy-phosphogluconate aldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2034(KHG/KDPG aldolase,keto-hydroxyglutarate-aldolase/keto-deoxy-phosphog luconate aldolase,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase,KDPG and KHG aldolase) b1850(multifunctional 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase and oxaloacetate decarboxylase) BN373_29511(2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase) t0993(hypothetical protein) SL1344_1818(KHG/KDPG aldolase) Cluster1153 1 1 1 1 1 1 1 ROD_18891(phosphoribosylglycinamide formyltransferase 2) ENC_06460(phosphoribosylglycinamide formyltransferase 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2035(Phosphoribosylglycinamide formyltransferase 2,phosphoribosylglycinamide formyltransferase 2,Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase),phosphoribosylglycinamide formyltransferase 2,ATP-grasp domain) b1849(phosphoribosylglycinamide formyltransferase 2) BN373_29501(phosphoribosylglycinamide formyltransferase 2) t0994(phosphoribosylglycinamide formyltransferase 2) SL1344_1817(phosphoribosylglycinamide formyltransferase 2) Cluster1154 1 1 1 1 1 1 1 ROD_18871(conserved hypothetical protein) ENC_12180(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2036(DNA damage-inducible protein YebG,Uncharacterized protein conserved in bacteria,YebG protein) b1848(conserved protein regulated by LexA) BN373_29491(SOS regulon DNA damage-inducible protein) t0995(conserved hypothetical protein) SL1344_1816(conserved hypothetical protein) Cluster1155 1 1 1 1 1 1 1 ROD_18851(putative membrane protein) ENC_06470(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2039(Inner membrane protein yebE,Protein of unknown function (DUF533)) b1846(inner membrane protein, DUF533 family) BN373_29481(conserved hypothetical protein) t0997(conserved hypothetical protein) SL1344_1814(conserved hypothetical protein) Cluster1156 1 1 1 1 1 1 1 ROD_18841(protease II) ENC_06480(Protease II) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2040(Protease 2,protease 2,Prolyl oligopeptidase, N-terminal beta-propeller domain) b1845(protease II) BN373_29471(oligopeptidase B) t0998(oligopeptidase) SL1344_1813(oligopeptidase) Cluster1157 1 1 1 1 1 1 1 ROD_18831(exodeoxyribonuclease X) ENC_06500(Exodeoxyribonuclease X) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2041(Exodeoxyribonuclease 10,exodeoxyribonuclease X,DNA polymerase III, epsilon subunit,Exonuclease) b1844(DNA exonuclease X) BN373_29461(exodeoxyribonuclease X) t0999(exodeoxyribonuclease X) SL1344_1812(exodeoxyribonuclease X) Cluster1158 1 1 1 1 1 1 1 ROD_18801(putative copper resistance protein) ENC_06530(Uncharacterized protein, homolog of Cu resistance protein CopC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2044(hypothetical protein,hypothetical protein,Copper resistance protein CopC) b1841(conserved protein) BN373_29441(conserved hypothetical protein) t1002(putative cation resistance protein) SL1344_1809(putative cation resistance protein) Cluster1159 1 1 1 1 1 1 1 ROD_18791(putative copper resistance protein) ENC_06540(Putative copper export protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2045(Inner membrane protein YebZ,Putative copper export protein,Copper resistance protein D) b1840(inner membrane protein) BN373_29431(putative copper resistance protein D) t1003(putative cation transporter) SL1344_1808(putative cation transporter) Cluster1160 1 1 1 1 1 1 1 ROD_18781(putative exported protein) ENC_06550(Protein of unknown function (DUF2511).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2046(Protein of unknown function (DUF2511)) b1839(predicted protein) BN373_29421(conserved hypothetical protein) t1004(putative exported protein) SL1344_1807(putative exported protein) Cluster1161 1 1 1 1 1 1 1 ROD_18751(conserved hypothetical protein) ENC_06590(16S rRNA m(5)C-1407 methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2052(Ribosomal RNA small subunit methyltransferase F,rRNA (cytosine-C(5)-)-methyltransferase RsmF,tRNA and rRNA cytosine-C5-methylases,NOL1/NOP2/sun family putative RNA methylase,NOL1/NOP2/sun family) b1835(16S rRNA m(5)C1407 methyltransferase, SAM-dependent) BN373_29361(NOL1/NOP2/sun family protein) t1028(conserved hypothetical protein) SL1344_1779(conserved hypothetical protein) Cluster1162 1 1 1 1 1 1 1 ROD_18731(putative membrane protein) ENC_06620(integral membrane protein, PqiA family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2054(Inner membrane protein yebS,paraquat-inducible membrane protein A,Uncharacterized paraquat-inducible protein A,integral membrane protein, PqiA family,Paraquat-inducible protein A) b1833(inner membrane protein) BN373_29341(integral membrane protein, PqiA family) t1030(putative membrane protein) SL1344_1777(putative membrane protein) Cluster1163 1 1 1 1 1 1 1 ROD_18721(putative signal transduction protein) ENC_06630(GAF domain-containing protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2055(Free methionine-R-sulfoxide reductase,Signal transduction protein containing GAF and PtsI domains,GAF domain) b1832(free methionine-(R)-sulfoxide reductase) BN373_29331(conserved hypothetical protein) t1031(conserved hypothetical protein) SL1344_1776(conserved hypothetical protein) Cluster1164 1 1 1 1 1 1 1 ROD_18711(ProP effector) ENC_06640(Activator of osmoprotectant transporter ProP) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2056(ProP effector,ProP expression regulator,ProQ/FINO family) b1831(RNA chaperone, probable regulator of ProP translation) BN373_29321(ProP effector) t1032(ProP effector) SL1344_1775(ProP effector) Cluster1165 1 1 1 1 1 1 1 ROD_18701(tail-specific protease) ENC_06650(C-terminal processing peptidase-1. Serine peptidase. MEROPS family S41A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2057(Tail-specific protease precursor,carboxy-terminal protease,C-terminal processing peptidase,Peptidase family S41) b1830(carboxy-terminal protease for penicillin-binding protein 3) BN373_29311(C-terminal processing peptidase) t1033(tail-specific protease precursor) SL1344_1774(tail-specific protease precursor) Cluster1166 1 1 1 1 1 1 1 ROD_18691(probable protease (heat shock protein)) ENC_06660(Zn-dependent protease with chaperone function) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2058(Protease HtpX,heat shock protein HtpX,Putative Zn-dependent protease,Peptidase family M48) b1829(predicted endopeptidase) BN373_29301(M48B family peptidase) t1034(heat shock protein) SL1344_1773(heat shock protein) Cluster1167 1 1 1 1 1 1 1 ROD_18671(IclR-family transcriptional regulator) ENC_06680(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2060(Transcriptional regulator kdgR,DNA-binding transcriptional regulator KdgR,beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family,Bacterial transcriptional regulator) b1827(DNA-binding transcriptional regulator f kdgK, kdgT, eda) BN373_29281(transcriptional regulator KdgR) t1036(transcriptional regulator KdgR) SL1344_1771(transcriptional regulator KdgR) Cluster1168 1 1 1 1 1 1 1 ROD_18661(putative exported protein) ENC_06690(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2061(hypothetical protein) b4536(predicted protein) BN373_29271(conserved hypothetical protein) t1037(putative exported protein) SL1344_1770(putative exported protein) Cluster1169 1 1 1 1 1 1 1 ROD_18601(ribosomal RNA large subunit methyltransferase A) ENC_06740(23S rRNA m(1)G-745 methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2064(Ribosomal RNA large subunit methyltransferase A,23S rRNA methyltransferase A,Trans-aconitate methyltransferase,biotin biosynthesis protein BioC,Methyltransferase domain) b1822(23S rRNA m(1)G745 methyltransferase) BN373_29221(ribosomal RNA large subunit methyltransferase A) t1043(rRNA guanine-N1-methyltransferase) SL1344_1764(rRNA guanine-N1-methyltransferase) Cluster1170 1 1 1 1 1 1 1 ROD_18591(putative outer membrane protein) ENC_06750(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2065(hypothetical protein,hypothetical protein,putative sporulation protein YtaF,Domain of unknown function DUF) b1821(conserved inner membrane protein) BN373_29211(putative membrane protein) t1044(putative membrane protein) SL1344_1763(putative membrane protein) Cluster1171 1 1 1 1 1 1 1 ROD_18581(putative membrane protein) ENC_06760(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2066(hypothetical protein,hypothetical protein,Predicted membrane protein,Protein of unknown function (DUF986)) b1820(inner membrane protein, UPF0266 family) BN373_29191(conserved hypothetical protein) t1045(putative membrane protein) SL1344_1762(putative membrane protein) Cluster1172 1 1 1 1 1 1 1 ROD_18571(mannose-specific PTS system EIID component) ENC_06770(PTS system D-mannose-specific IID component, Man family (TC 4.A.6.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2067(PTS system mannose-specific EIID component,PTS system mannose-specific transporter subunit IID,PTS system, mannose/fructose/sorbose family, IID component,PTS system mannose/fructose/sorbose family IID component) b1819(mannose-specific enzyme IID component of PTS) BN373_29181(mannose permease IID component) t1046(phosphotransferase enzyme II, D component) SL1344_1761(phosphotransferase enzyme II, D component) Cluster1173 1 1 1 1 1 1 1 ROD_18561(mannose-specific PTS system EIIC component) ENC_06780(PTS system D-mannose-specific IIC component, Man family (TC 4.A.6.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2068(PTS system mannose-specific EIIC component,PTS system mannose-specific transporter subunit IIC,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC,PTS system, mannose/fructose/sorbose family, IIC component,PTS system sorbose-specific iic component) b1818(mannose-specific enzyme IIC component of PTS) BN373_29171(mannose permease IIC component) t1047(phosphotransferase enzyme II, C component) SL1344_1760(phosphotransferase enzyme II, C component) Cluster1174 1 1 1 1 1 1 1 ROD_18551(mannose-specific PTS system EIIAB component) ENC_06790(PTS system D-mannose-specific IIA component, Man family (TC 4.A.6.1.1)/PTS system D-mannose-specific IIB component, Man family (TC 4.A.6.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2069(EIIAB-Man,PTS system mannose-specific transporter subunits IIAB,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,PTS system, mannose/fructose/sorbose family, IIB component,PTS system sorbose subfamily IIB component) b1817(fused mannose-specific PTS enzymes: IIA component/IIB component) BN373_29161(PTS system mannose-specific EIIAB component) t1048(mannose-specific IIAB component of PTS system) SL1344_1759(PTS system, mannose-specific IIAB component) Cluster1175 1 1 1 1 1 1 1 ROD_18531(putative signal transduction protein) ENC_06820(FOG: EAL domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2071(Cyclic di-GMP phosphodiesterase yahA,phage resistance protein,Predicted signal transduction protein containing sensor and EAL domains,EAL domain) b1815(predicted phosphodiesterase) BN373_29141(conserved hypothetical protein) t1050(conserved hypothetical protein) SL1344_1756(conserved hypothetical protein) Cluster1176 1 1 1 1 1 1 1 ROD_18501(para-aminobenzoate synthase component I) ENC_06850(aminodeoxychorismate synthase, subunit I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2074(Para-aminobenzoate synthase component 1,aminodeoxychorismate synthase subunit I,Anthranilate/para-aminobenzoate synthases component I,aminodeoxychorismate synthase, component I,chorismate binding enzyme) b1812(aminodeoxychorismate synthase, subunit I) BN373_29111(aminodeoxychorismate synthase, component I) t1053(para-aminobenzoate synthase component I) SL1344_1753(para-aminobenzoate synthase component I) Cluster1177 1 1 1 1 1 1 1 ROD_18491(conserved hypothetical protein) ENC_06860(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2075(hypothetical protein,Uncharacterized protein conserved in bacteria,Uncharacterised protein family (UPF0181)) b1811(conserved protein) BN373_29101(conserved hypothetical protein) t1054(conserved hypothetical protein) SL1344_1752(hypothetical protein) Cluster1178 1 1 1 1 1 1 1 ROD_18481(putative endoribonuclease) ENC_06870(Putative translation initiation inhibitor, yjgF family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2077(Enamine/imine deaminase,putative endoribonuclease L-PSP,putative endoribonuclease L-PSP,Endoribonuclease L-PSP) b1809(conserved protein, UPF0076 famiily) BN373_29091(endoribonuclease L-PSP family protein) t1055(conserved hypothetical protein) SL1344_1751(conserved hypothetical protein) Cluster1179 1 1 1 1 1 1 1 ROD_18461(conserved hypothetical protein) ENC_06900(Inactive homolog of metal-dependent proteases, putative molecular chaperone) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2079(hypothetical protein,UGMP family protein,universal bacterial protein YeaZ,Glycoprotease family) b1807(protease specific for Gcp(YgjD), essential for nucleoid maintanence) BN373_29071(glycoprotease family protein) t1057(conserved hypothetical protein) SL1344_1749(conserved hypothetical protein) Cluster1180 1 1 1 1 1 1 1 ROD_18451(putative lipoprotein) ENC_06910(outer membrane lipoprotein, Slp family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2080(Outer membrane protein slp precursor,Starvation-inducible outer membrane lipoprotein,outer membrane lipoprotein, Slp family,Outer membrane lipoprotein Slp family) b1806(lipoprotein, RpoE-regulated, fucntion unknown) BN373_29061(outer membrane protein Slp) t1058(putative lipoprotein) SL1344_1748(putative lipoprotein) Cluster1181 1 1 1 1 1 1 1 ROD_18431(ribonuclease D) ENC_06930(ribonuclease D) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2082(Ribonuclease D,ribonuclease D,Ribonuclease D,ribonuclease D,3'-5' exonuclease) b1804(ribonuclease D) BN373_29041(ribonuclease D) t1060(ribonuclease D) SL1344_1745(ribonuclease D) Cluster1182 1 1 1 1 1 1 1 ROD_18401(Cell division topological specificity factor) ENC_06940(cell division topological specificity factor MinE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2710(Cell division topological specificity factor,cell division topological specificity factor MinE,cell division topological specificity factor MinE,Septum formation topological specificity factor MinE) b1174(cell division topological specificity factor) BN373_29031(cell division topological specificity factor MinE) t1061(cell division topological specificity factor) SL1344_1744(Cell division topological specificity factor) Cluster1183 1 1 1 1 1 1 1 ROD_18391(septum site determining protein) ENC_06950(septum site-determining protein MinD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2709(Cell division inhibitor MinD,cell division inhibitor MinD,Septum formation inhibitor-activating ATPase,septum site-determining protein MinD,CobQ/CobB/MinD/ParA nucleotide binding domain) b1175(membrane ATPase of the MinC-MinD-MinE system) BN373_29021(septum site-determining protein MinD) t1062(septum site determining protein) SL1344_1743(septum site determining protein) Cluster1184 1 1 1 1 1 1 1 ROD_18381(septum site determining protein) ENC_06960(septum site-determining protein MinC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2708(Septum site-determining protein MinC,septum formation inhibitor,septum site-determining protein MinC,Septum formation inhibitor MinC, C-terminal domain) b1176(cell division inhibitor) BN373_29011(septum site-determining protein MinC) t1063(septum site determining protein) SL1344_1742(Probable septum site-determining protein minC) Cluster1185 1 1 1 1 1 1 1 ROD_18371(conserved hypothetical protein) ENC_06970(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2705(hypothetical protein,YcgL domain) b1179(conserved protein) BN373_29001(conserved hypothetical protein) t1064(conserved hypothetical protein) SL1344_1741(conserved hypothetical protein) Cluster1186 1 1 1 1 1 1 1 ROD_18361(putative hydrolase) ENC_06980(2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2704(hypothetical protein,hypothetical protein,2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway),4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit,Fumarylacetoacetate (FAA) hydrolase family) b1180(predicted isomerase/hydrolase) BN373_28991(fumarylacetoacetate hydrolase family protein) t1065(putative hydrolase) SL1344_1740(putative hydrolase) Cluster1187 1 1 1 1 1 1 1 ROD_18351(conserved hypothetical protein) ENC_06990(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2703(hypothetical protein,Uncharacterized conserved protein,Flagellin N-methylase) b1181(conserved protein) BN373_28981(conserved hypothetical protein) t1066(conserved hypothetical protein) SL1344_1739(hypothetical protein) Cluster1188 1 1 1 1 1 1 1 ROD_18311(fatty acid metabolism regulator protein) ENC_07020(fatty acid metabolism transcriptional regulator FadR) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2696(Fatty acid metabolism regulator protein,fatty acid metabolism regulator,Transcriptional regulators,fatty acid metabolism transcriptional regulator FadR,FadR C-terminal domain) b1187(DNA-binding transcriptional dual regulator of fatty acid metabolism) BN373_28941(fatty acid metabolism transcriptional regulator FadR) t1072(fatty acid-fatty acyl responsive DNA-binding protein) SL1344_1733(Fatty acid metabolism regulator protein) Cluster1189 1 1 1 1 1 1 1 ROD_18301(conserved hypothetical protein) ENC_07030(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2695(SpoVR family protein,Uncharacterized conserved protein,SpoVR like protein) b1188(conserved protein) BN373_28931(SpoVR-like protein) t1073(conserved hypothetical protein) SL1344_1732(conserved hypothetical protein) Cluster1190 1 1 1 1 1 1 1 ROD_18291(D-amino acid dehydrogenase small subunit) ENC_07040(D-amino acid dehydrogenase small subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2694(Sarcosine oxidase subunit beta,D-amino acid dehydrogenase small subunit,Glycine cleavage system T protein (aminomethyltransferase),glycine oxidase ThiO,FAD dependent oxidoreductase) b1189(D-amino acid dehydrogenase) BN373_28921(D-amino acid dehydrogenase, small subunit) t1074(D-amino acid dehydrogenase) SL1344_1731(D-amino acid dehydrogenase small subunit) Cluster1191 1 1 1 1 1 1 1 ROD_18281(alanine racemase, catabolic) ENC_07050(alanine racemase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2693(Alanine racemase, catabolic,alanine racemase,Uncharacterized protein conserved in bacteria,alanine racemase,Alanine racemase, N-terminal domain) b1190(alanine racemase 2, PLP-binding) BN373_28911(alanine racemase) t1075(alanine racemase) SL1344_1730(Alanine racemase) Cluster1192 1 1 1 1 1 1 1 ROD_18271(cell volume regulation protein A) ENC_07060(potassium/proton antiporter, CPA1 family (TC 2.A.36)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2692(potassium/proton antiporter,NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain,Na+/H+ antiporter,Sodium/hydrogen exchanger family) b1191(predicted cation/proton antiporter) BN373_28901(cell volume regulation protein A) t1076(putative Na+/H+ exchanger) SL1344_1729(Cell volume regulation protein A. Cell volume regulation protein A homolog) Cluster1193 1 1 1 1 1 1 1 ROD_18261(muramoyltetrapeptide carboxypeptidase) ENC_07070(murein tetrapeptidase LD-carboxypeptidase . Serine peptidase. MEROPS family S66) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2691(Murein tetrapeptide carboxypeptidase,L,D-carboxypeptidase A,LD-carboxypeptidase) b1192(L,D-carboxypeptidase A) BN373_28891(muramoyltetrapeptide carboxypeptidase) t1077(conserved hypothetical protein) SL1344_1728(conserved hypothetical protein) Cluster1194 1 1 1 1 1 1 1 ROD_18251(membrane-bound lytic murein transglycosylase E) ENC_07080(Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2690(Endo-type membrane-bound lytic murein transglycosylase A precursor,lytic murein endotransglycosylase E,Transglycosylase SLT domain) b1193(lytic murein endotransglycosylase E) BN373_28881(membrane-bound lytic murein transglycosylase E) t1078(membrane-bound lytic murein transglycosylase E) SL1344_1727(membrane-bound lytic murein transglycosylase E) Cluster1195 1 1 1 1 1 1 1 ROD_47591(tdc operon transcriptional activator) ENC_33690(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.572(HTH-type transcriptional regulator AbgR,DNA-binding transcriptional activator TdcA,pca operon transcription factor PcaQ,LysR substrate binding domain) b3118(DNA-binding transcriptional activator) BN373_28751(transcriptional regulator tdcA) t3165(TDC operon transcriptional activator) SL1344_3217(TDC operon transcriptional activator) Cluster1196 1 1 1 1 1 1 1 ROD_47601(catabolic threonine dehydratase) ENC_33680(L-threonine ammonia-lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.573(L-threonine dehydratase catabolic TdcB,threonine dehydratase,Threonine dehydratase,threonine ammonia-lyase,Pyridoxal-phosphate dependent enzyme) b3117(catabolic threonine dehydratase, PLP-dependent) BN373_28741(threonine dehydratase, catabolic) t3164(catabolic threonine dehydratase) SL1344_3216(catabolic threonine dehydratase) Cluster1197 1 1 1 1 1 1 1 ROD_47621(propionate kinase) ENC_33660(propanoate kinase /acetate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.575(Propionate kinase,propionate/acetate kinase,Acetate kinase,acetate kinase,Acetokinase family) b3115(propionate kinase/acetate kinase C, anaerobic) BN373_28721(propionate kinase) t3162(propionate kinase) SL1344_3214(propionate kinase) Cluster1198 1 1 1 1 1 1 1 ROD_27991(conserved hypothetical protein) ENC_11460(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3617(Uncharacterized protein conserved in bacteria,Uncharacterized protein conserved in bacteria (DUF2058)) b0354(predicted protein) BN373_28561(conserved hypothetical protein) t4119(conserved hypothetical protein) SL1344_4127(conserved hypothetical protein) Cluster1199 1 1 1 1 1 1 1 ROD_18101(GTP-dependent nucleic acid-binding protein) ENC_07500(GTP-binding protein YchF) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2643(GTP-dependent nucleic acid-binding protein engD,GTP-binding protein YchF,Predicted GTPase, probable translation factor,GTP-binding protein YchF,Protein of unknown function (DUF933)) b1203(ATPase, K+-dependent, ribosome-associated) BN373_28371(GTP-binding protein EngD) t1092(putative ATP/GTP-binding protein) SL1344_1712(putative ATP/GTP-binding protein) Cluster1200 1 1 1 1 1 1 1 ROD_18081(putative outer membrane protein) ENC_07520(Protein of unknown function (DUF2583).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2641(hypothetical protein,Protein of unknown function (DUF2583)) b1205(predicted inner membrane protein) BN373_28351(conserved hypothetical protein) t1094(putative membrane protein) SL1344_1710(putative exported protein) Cluster1201 1 1 1 1 1 1 1 ROD_18061(ribose-phosphate pyrophosphokinase) ENC_07550(ribose-phosphate pyrophosphokinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2639(Ribose-phosphate pyrophosphokinase,ribose-phosphate pyrophosphokinase,ribose-phosphate diphosphokinase,Phosphoribosyl transferase domain) b1207(phosphoribosylpyrophosphate synthase) BN373_28321(ribose-phosphate pyrophosphokinase) t1096(ribose-phosphate pyrophosphokinase) SL1344_1708(Ribose-phosphate pyrophosphokinase) Cluster1202 1 1 1 1 1 1 1 ROD_18041(outer-membrane lipoprotein) ENC_07580(outer membrane lipoprotein LolB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2637(Outer-membrane lipoprotein lolB precursor,outer membrane lipoprotein LolB,outer membrane lipoprotein LolB,Outer membrane lipoprotein LolB) b1209(OM lipoprotein required for localization of lipoproteins) BN373_28301(outer membrane lipoprotein LolB) t1098(outer membrane lipoprotein) SL1344_1706(Outer-membrane lipoprotein lolB precursor) Cluster1203 1 1 1 1 1 1 1 ROD_18031(glutamyl-tRNA reductase) ENC_07590(glutamyl-tRNA reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2636(Glutamyl-tRNA reductase,glutamyl-tRNA reductase,Glutamyl-tRNA reductase,glutamyl-tRNA reductase,Glutamyl-tRNAGlu reductase, N-terminal domain) b1210(glutamyl tRNA reductase) BN373_28291(glutamyl-tRNA reductase) t1099(glutamyl-tRNA reductase) SL1344_1705(Glutamyl-tRNA reductase) Cluster1204 1 1 1 1 1 1 1 ROD_18011(protein methyltransferase hemk (protein-glutamine N methyltransferase)) ENC_07620([protein release factor]-glutamine N5-methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2634(Release factor glutamine methyltransferase,N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase,Methylase of polypeptide chain release factors,methyltransferase, HemK family,Methyltransferase small domain) b1212(N5-glutamine methyltransferase, modifies release factors RF-1 and RF-2) BN373_28271(protein-(glutamine-N5) methyltransferase, release factor-specific) t1101(HemK protein) SL1344_1703(HemK protein, putative protoporphyrinogen oxidase) Cluster1205 1 1 1 1 1 1 1 ROD_18001(putative membrane protein) ENC_07630(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2633(hypothetical protein,hypothetical protein,Invasion gene expression up-regulator, SirB) b1213(predicted inner membrane protein, SIRB family) BN373_28261(putative Invasion gene expression up-regulator SirB) t1102(putative regulator) SL1344_1702(putative regulator) Cluster1206 1 1 1 1 1 1 1 ROD_17991(protein SirB1) ENC_07640(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2632(hypothetical protein) b1214(conserved protein) BN373_28251(SirB1 protein) t1103(putative regulator) SL1344_1701(putative regulator) Cluster1207 1 1 1 1 1 1 1 ROD_17971(calcium/proton antiporter) ENC_07660(calcium/proton exchanger) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2628(Calcium/proton antiporter,calcium/sodium:proton antiporter,Ca2+/H+ antiporter,calcium/proton exchanger,Sodium/calcium exchanger protein) b1216(calcium/sodium:proton antiporter) BN373_28231(calcium/proton antiporter) t1680(putative calcium/proton antiporter) SL1344_1699(putative calcium/proton antiporter) Cluster1208 1 1 1 1 1 1 1 ROD_17961(cation transport regulator) ENC_07670(Putative cation transport regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2627(Cation transport regulator ChaB,cation transport regulator,Putative cation transport regulator,ChaB) b1217(cation transport regulator) BN373_28221(cation transport regulator) t1679(cation transport regulator ChaB) SL1344_1698(cation transport regulator ChaB) Cluster1209 1 1 1 1 1 1 1 ROD_17931(conserved hypothetical protein) ENC_07720(Uncharacterized conserved protein involved in intracellular sulfur reduction) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2625(hypothetical protein,Uncharacterized conserved protein involved in intracellular sulfur reduction,sulfur relay protein TusD/DsrE,DsrE/DsrF-like family) b1219(conserved protein) BN373_28191(DsrE/DsrF family protein) t1678(conserved hypothetical protein) SL1344_1697(conserved hypothetical protein) Cluster1210 1 1 1 1 1 1 1 ROD_17851(nitrate/nitrite two-component response regulator) ENC_07810(Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2623(Nitrate/nitrite response regulator protein narL,transcriptional regulator NarL,Signal transduction histidine kinase, nitrate/nitrite-specific,sporulation transcription factor Spo0A,Response regulator receiver domain) b1221(DNA-binding response regulator in two-component regulatory system with NarX (or NarQ)) BN373_28111(nitrate/nitrite response regulator protein NarL) t1675(nitrate/nitrite response regulator protein NarL) SL1344_1695(nitrate/nitrite response regulator protein NarL) Cluster1211 1 1 1 1 1 1 1 ROD_17801(respiratory nitrate reductase 1 delta chain) ENC_07880(respiratory nitrate reductase chaperone NarJ) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2617(Redox enzyme maturation protein NarJ,nitrate reductase 2 subunit delta,nitrate reductase molybdenum cofactor assembly chaperone,Nitrate reductase delta subunit) b1226(molybdenum-cofactor-assembly chaperone subunit (delta subunit) of nitrate reductase 1) BN373_28061(nitrate reductase molybdenum cofactor assembly chaperone 1) t1671(respiratory nitrate reductase 1 delta chain) SL1344_1690(respiratory nitrate reductase 1 delta chain) Cluster1212 1 1 1 1 1 1 1 ROD_17791(respiratory nitrate reductase 1 gamma chain) ENC_07890(respiratory nitrate reductase gamma subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2616(Respiratory nitrate reductase 1 gamma chain,Nitrate reductase gamma subunit,respiratory nitrate reductase, gamma subunit,Nitrate reductase gamma subunit) b1227(nitrate reductase 1, gamma (cytochrome b(NR)) subunit) BN373_28051(respiratory nitrate reductase 1, gamma subunit) t1670(respiratory nitrate reductase 1 gamma chain) SL1344_1689(respiratory nitrate reductase 1 gamma chain) Cluster1213 1 1 1 1 1 1 1 ROD_17761(formyltetrahydrofolate deformylase) ENC_07900(formyltetrahydrofolate deformylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2607(Formyltetrahydrofolate deformylase,formyltetrahydrofolate deformylase,Folate-dependent phosphoribosylglycinamide formyltransferase PurN,formyltetrahydrofolate deformylase,Formyl transferase) b1232(formyltetrahydrofolate hydrolase) BN373_28021(formyltetrahydrofolate deformylase) t1667(formyltetrahydrofolate deformylase) SL1344_1687(formyltetrahydrofolate deformylase) Cluster1214 1 1 1 1 1 1 1 ROD_17741(patatin-like phospholipase) ENC_07920(Predicted esterase of the alpha-beta hydrolase superfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2605(NTE family protein rssA,hypothetical protein,Patatin-like phospholipase) b1234(predicted phospholipase, patatin-like family) BN373_28001(phospholipase, patatin family) t1665(conserved hypothetical protein) SL1344_1685(conserved hypothetical protein) Cluster1215 1 1 1 1 1 1 1 ROD_17731(orphan two-component response regulator) ENC_07930(Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2604(hypothetical protein,response regulator of RpoS,Response regulator of citrate/malate metabolism,heavy metal response regulator,Response regulator receiver domain) b1235(response regulator binding RpoS to initiate proteolysis by ClpXP; required for the PcnB-degradosome interaction during stationary phase) BN373_27991(response regulator) t1664(putative regulatory protein) SL1344_1684(putative regulatory protein) Cluster1216 1 1 1 1 1 1 1 ROD_17721(UTP--glucose-1-phosphate uridylyltransferase) ENC_07940(UTP-glucose-1-phosphate uridylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2603(UTP--glucose-1-phosphate uridylyltransferase,UTP--glucose-1-phosphate uridylyltransferase subunit GalU,CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes,UTP-glucose-1-phosphate uridylyltransferase,Nucleotidyl transferase) b1236(glucose-1-phosphate uridylyltransferase) BN373_27981(UTP-glucose-1-phosphate uridylyltransferase) t1663(glucose-1-phosphate uridylyltransferase) SL1344_1683(glucose-1-phosphate uridylyltransferase) Cluster1217 1 1 1 1 1 1 1 ROD_17711(DNA-binding protein H-NS (Histone-like protein HLP-II)) ENC_07950(nucleoid protein H-NS) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2602(Pathogenesis protein kcpA,global DNA-binding transcriptional dual regulator H-NS,H-NS histone family) b1237(global DNA-binding transcriptional dual regulator H-NS) BN373_27971(DNA-binding protein H-NS) t1662(DNA-binding protein) SL1344_1682(DNA-binding protein (histone-like protein Hlp-II)) Cluster1218 1 1 1 1 1 1 1 ROD_17691(thymidine kinase) ENC_07960(thymidine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2601(Thymidine kinase,thymidine kinase,Thymidine kinase) b1238(thymidine kinase/deoxyuridine kinase) BN373_27961(thymidine kinase) t1661(thymidine kinase) SL1344_1681(Thymidine kinase) Cluster1219 1 1 1 1 1 1 1 ROD_17641(oligopeptide ABC transporter, permease protein) ENC_08010(ABC-type dipeptide/oligopeptide/nickel transport systems, permease components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2594(Oligopeptide transport system permease protein oppB,oligopeptide transporter permease,nickel ABC transporter, permease subunit NikB,Binding-protein-dependent transport system inner membrane component) b1244(oligopeptide transporter subunit) BN373_27921(oligopeptide ABC transporter, permease protein OppB) t1657(oligopeptide transport system permease protein OppB) SL1344_1676(oligopeptide transport system permease protein (OppB)) Cluster1220 1 1 1 1 1 1 1 ROD_17621(oligopeptide ABC transporter, ATP-binding protein) ENC_08030(oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2592(Glutathione import ATP-binding protein GsiA,oligopeptide transporter ATP-binding component,ABC-type oligopeptide transport system, ATPase component,nickel import ATP-binding protein NikD,Oligopeptide/dipeptide transporter, C-terminal region) b1246(oligopeptide transporter subunit) BN373_27901(oligopeptide ABC transporter, ATP-binding protein OppD) t1655(oligopeptide transport ATP-binding protein OppD) SL1344_1674(oligopeptide transport ATP-binding protein (OppD)) Cluster1221 1 1 1 1 1 1 1 ROD_17611(oligopeptide ABC transporter, ATP-binding protein) ENC_24760(oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2591(Glutathione import ATP-binding protein GsiA,oligopeptide ABC transporter ATP-binding protein OppF,ABC-type oligopeptide transport system, ATPase component,nickel import ATP-binding protein NikE,ABC transporter) b1247(oligopeptide transporter subunit) BN373_27891(oligopeptide ABC transporter, ATP-binding protein OppF) t1654(oligopeptide transport ATP-binding protein OppF) SL1344_1673(oligopeptide transport ATP-binding protein (OppF)) Cluster1222 1 1 1 1 1 1 1 ROD_17601(conserved hypothetical protein) ENC_08060(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2590(hypothetical protein,dsDNA-mimic protein,Protein of unknown function, DUF440) b1248(conserved protein, UPF0263 family) BN373_27871(conserved hypothetical protein) t1652(conserved hypothetical protein) SL1344_1671(conserved hypothetical protein) Cluster1223 1 1 1 1 1 1 1 ROD_17591(cardiolipin synthetase) ENC_08070(cardiolipin synthetase 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2589(Cardiolipin synthase,cardiolipin synthetase,cardiolipin synthase,Phospholipase D Active site motif) b1249(cardiolipin synthase 1) BN373_27861(cardiolipin synthetase) t1651(cardiolipin synthetase) SL1344_1670(Cardiolipin synthetase) Cluster1224 1 1 1 1 1 1 1 ROD_17561(TonB protein) ENC_08110(outer membrane transport energization protein TonB (TC 2.C.1.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2586(hypothetical protein,transport protein TonB,TonB family C-terminal domain,Gram-negative bacterial tonB protein) b1252(membrane spanning protein in TonB-ExbB-ExbD transport complex) BN373_27721(protein TonB) t1649(TonB protein) SL1344_1668(TonB protein) Cluster1225 1 1 1 1 1 1 1 ROD_13311(putative kinase) ENC_14250(Fructosamine-3-kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2154(Fructosamine-3-kinase,Fructosamine kinase) b1725(predicted phosphotransferase/kinase) BN373_27711(fructosamine kinase family protein) t1204(conserved hypothetical protein) SL1344_1259(conserved hypothetical protein) Cluster1226 1 1 1 1 1 1 1 ROD_13321(conserved hypothetical protein) ENC_14240(Protein of unknown function (DUF2622).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2155(Protein of unknown function (DUF2622)) b1724(predicted protein) BN373_27701(conserved hypothetical protein) t1205(conserved hypothetical protein) SL1344_1260(conserved hypothetical protein) Cluster1227 1 1 1 1 1 1 1 ROD_13331(6-phosphofructokinase isozyme 2 (phosphofructokinase-2)) ENC_14230(6-phosphofructokinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2156(6-phosphofructokinase isozyme 2,6-phosphofructokinase 2,ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase,hexose kinase, 1-phosphofructokinase family,pfkB family carbohydrate kinase) b1723(6-phosphofructokinase II) BN373_27691(6-phosphofructokinase 2) t1206(6-phosphofructokinase isozyme) SL1344_1261(6-phosphofructokinase isozyme) Cluster1228 1 1 1 1 1 1 1 ROD_13341(putative exported protein) ENC_14210(Putative salt-induced outer membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2157(Putative salt-induced outer membrane protein,Protein of unknown function, DUF481) b1722(predicted outer membrane protein, acid-inducible) BN373_27681(conserved hypothetical protein) t1207(putative outer membrane protein) SL1344_1262(putative outer membrane protein) Cluster1229 1 1 1 1 1 1 1 ROD_13371(threonyl-tRNA synthetase) ENC_14180(threonyl-tRNA synthetase /Ser-tRNA(Thr) hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2160(Threonine--tRNA ligase,threonyl-tRNA synthetase,Prolyl-tRNA synthetase,threonine--tRNA ligase,tRNA synthetase class II core domain (G, H, P, S and T)) b1719(threonyl-tRNA synthetase) BN373_27661(threonyl-tRNA synthetase) t1213(threonyl-tRNA synthetase) SL1344_1267(Threonyl-tRNA synthetase) Cluster1230 1 1 1 1 1 1 1 ROD_13401(50S ribosomal subunit protein L20) ENC_14150(LSU ribosomal protein L20P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2163(50S ribosomal protein L20,50S ribosomal protein L20,ribosomal protein L20,Ribosomal protein L20) b1716(50S ribosomal subunit protein L20) BN373_27631(ribosomal protein L20) t1216(50S ribosomal subunit protein L20) SL1344_1270(50S ribosomal protein L20. Chloroplast 50S ribosomal protein L20) Cluster1231 1 1 1 1 1 1 1 ROD_13411(Phenylalanyl-tRNA synthetase alpha chain) ENC_14140(phenylalanyl-tRNA synthetase, alpha subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2165(Phenylalanine--tRNA ligase alpha subunit,phenylalanyl-tRNA synthetase subunit alpha,Phenylalanyl-tRNA synthetase alpha subunit,phenylalanine--tRNA ligase, alpha subunit,tRNA synthetases class II core domain (F)) b1714(phenylalanine tRNA synthetase, alpha subunit) BN373_27621(phenylalanyl-tRNA synthetase, alpha subunit) t1218(phenylalanyl-tRNA synthetase alpha chain) SL1344_1271(phenylalanyl-tRNA synthetase alpha chain) Cluster1232 1 1 1 1 1 1 1 ROD_13421(Phenylalanyl-tRNA synthetase beta chain) ENC_14130(phenylalanyl-tRNA synthetase beta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2166(Phenylalanine--tRNA ligase beta subunit,phenylalanyl-tRNA synthetase subunit beta,EMAP domain,phenylalanine--tRNA ligase, beta subunit,B3/4 domain) b1713(phenylalanine tRNA synthetase, beta subunit) BN373_27611(phenylalanyl-tRNA synthetase, beta subunit) t1219(phenylalanyl-tRNA synthetase beta chain) SL1344_1272(Phenylalanyl-tRNA synthetase beta chain) Cluster1233 1 1 1 1 1 1 1 ROD_13441(Vitamin B12 ABC transporter, permease protein) ENC_14100(ABC-type cobalamin transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2168(Vitamin B12 import system permease protein BtuC,vtamin B12-transporter permease,ABC-type cobalamin transport system, permease component,proposed F420-0 ABC transporter, permease protein,FecCD transport family) b1711(vitamin B12 transporter subunit: membrane component of ABC superfamily) BN373_27551(vitamin B12 import system permease protein BtuC) t1221(vitamin B12 transport system permease) SL1344_1274(Vitamin B12 transport system permease protein btuC) Cluster1234 1 1 1 1 1 1 1 ROD_13451(vitamin B12 transport periplasmic protein (putative glutathione peroxidase)) ENC_14090(Glutathione peroxidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2169(Glutathione peroxidase homolog BsaA,putative glutathione peroxidase,putative glutathione peroxidase Gpx7,Glutathione peroxidase) b1710(glutathione peroxidase) BN373_27531(vitamin B12 transport periplasmic protein BtuE) t1222(putative glutathione peroxidase) SL1344_1275(putative glutathione peroxidase/vitamin B12 transport periplasmic protein BtuE) Cluster1235 1 1 1 1 1 1 1 ROD_13461(vitamin B12 ABC transporter, ATP-binding protein) ENC_14080(ABC-type cobalamin transport system, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2170(Vitamin B12 import ATP-binding protein BtuD,vitamin B12-transporter ATPase,ABC-type enterochelin transport system, ATPase component,proposed F420-0 ABC transporter, ATP-binding protein,ABC transporter) b1709(vitamin B12 transporter subunit : ATP-binding component of ABC superfamily) BN373_27521(vitamin B12 import ATP-binding protein BtuD) t1223(vitamin B12 ABC transport ATP-binding protein) SL1344_1276(vitamin B12 ABC transport ATP-binding protein) Cluster1236 1 1 1 1 1 1 1 ROD_13471(putative lipoprotein) ENC_14070(Cell wall-associated hydrolases (invasion-associated proteins)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2171(Probable endopeptidase Spr precursor,outer membrane lipoprotein,Uncharacterized protein conserved in bacteria,putative phage cell wall peptidase, NlpC/P60 family,NlpC/P60 family) b1708(predicted peptidase, C40 clan, lipoprotein) BN373_27511(lipoprotein, NlpC/P60 family) t1224(putative lipoprotein) SL1344_1277(putative lipoprotein) Cluster1237 1 1 1 1 1 1 1 ROD_13491(conserved hypothetical protein) ENC_14050(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2173(hypothetical protein,Uncharacterized conserved protein,Uncharacterized ACR, YdiU/UPF0061 family) b1706(conserved protein, UPF0061 family) BN373_27501(conserved hypothetical protein) t1226(conserved hypothetical protein) SL1344_1279(conserved hypothetical protein) Cluster1238 1 1 1 1 1 1 1 ROD_13501(conserved hypothetical protein) ENC_13990(Hemin uptake protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2174(hypothetical protein,Hemin uptake protein,Hemin uptake protein hemP) b1705(hemin uptake protein HemP homolog) BN373_27491(conserved hypothetical protein) t1227(conserved hypothetical protein) SL1344_1280(conserved hypothetical protein) Cluster1239 1 1 1 1 1 1 1 ROD_13511(phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive) ENC_13980(3-deoxy-D-arabinoheptulosonate-7-phosphate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2175(Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive,phospho-2-dehydro-3-deoxyheptonate aldolase,3-deoxy-7-phosphoheptulonate synthase,DAHP synthetase I family) b1704(3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible) BN373_27481(3-deoxy-7-phosphoheptulonate synthase, Trp-sensitive) t1228(3-deoxy-D-arabinoheptulosonate 7-phosphate synthase) SL1344_1281(3-deoxy-D-arabinoheptulosonate 7-phosphate synthase) Cluster1240 1 1 1 1 1 1 1 ROD_13621(putative outer membrane protein) ENC_13930(Predicted permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2192(hypothetical protein,putative inner membrane protein,sporulation integral membrane protein YtvI,Domain of unknown function DUF20) b1688(inner membrane protein, UPF0118 family) BN373_27451(inner membrane protein YdiK) t1232(putative membrane protein) SL1344_1298(lipoprotein) Cluster1241 1 1 1 1 1 1 1 ROD_13641(esterase) ENC_13900(uncharacterized domain 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2194(Esterase YdiI,acyl-CoA esterase,Uncharacterized protein, possibly involved in aromatic compounds catabolism,uncharacterized domain 1,Thioesterase superfamily) b1686(acyl-CoA esterase in vitro) BN373_27431(esterase YdiI) t1234(conserved hypothetical protein) SL1344_1300(conserved hypothetical protein) Cluster1242 1 1 1 1 1 1 1 ROD_12571(putative transglycosylase associated protein) ENC_14960(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2086(hypothetical protein,Transglycosylase associated protein) b1795(conserved protein, UPF0410 family) BN373_27421(putative membrane protein) t1153(putative membrane protein) SL1344_1210(putative inner membrane protein) Cluster1243 1 1 1 1 1 1 1 ROD_13661(Fe-S cluster assembly protein) ENC_13700(FeS assembly scaffold SufA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2197(hypothetical protein,iron-sulfur cluster assembly scaffold protein,FeS assembly scaffold SufA,Iron-sulphur cluster biosynthesis) b1684(Fe-S cluster assembly protein) BN373_27261(FeS assembly scaffold SufA) t1237(conserved hypothetical protein) SL1344_1303(conserved hypothetical protein) Cluster1244 1 1 1 1 1 1 1 ROD_13671(component of SufB-SufC-SufD cysteine desulfurase activator complex) ENC_13690(Iron-regulated ABC transporter membrane component SufB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2198(FeS cluster assembly protein sufB,cysteine desulfurase activator complex subunit SufB,FeS assembly protein SufB,Uncharacterized protein family (UPF0051)) b1683(component of SufBCD complex) BN373_27251(FeS assembly protein SufB) t1238(conserved hypothetical protein) SL1344_1304(conserved hypothetical protein) Cluster1245 1 1 1 1 1 1 1 ROD_13681(ABC transport ATP-binding protein (component of SufBCD complex)) ENC_13680(Iron-regulated ABC transporter ATPase subunit SufC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2199(Probable ATP-dependent transporter SufC,cysteine desulfurase ATPase component,ABC-type transport system involved in Fe-S cluster assembly, ATPase component,FeS assembly ATPase SufC,ABC transporter) b1682(component of SufBCD complex, ATP-binding component of ABC superfamily) BN373_27241(FeS assembly ATPase SufC) t1239(putative ABC transport ATP-binding subunit) SL1344_1305(putative ABC transport ATP-binding subunit) Cluster1246 1 1 1 1 1 1 1 ROD_13691(component of SufB-SufC-SufD cysteine desulfurase activator complex) ENC_13670(Iron-regulated ABC transporter permease protein SufD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2200(FeS cluster assembly protein sufD,cysteine desulfurase activator complex subunit SufD,FeS assembly protein SufD,Uncharacterized protein family (UPF0051)) b1681(FeS cluster assembly protein of SufBCD complex) BN373_27231(FeS assembly protein SufD) t1240(conserved hypothetical protein) SL1344_1306(conserved hypothetical protein) Cluster1247 1 1 1 1 1 1 1 ROD_13701(cysteine desulfurase (selenocysteine lyase)) ENC_13660(cysteine desulfurase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2201(Cysteine desulfurase,bifunctional cysteine desulfurase/selenocysteine lyase,Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase,cysteine desulfurase, SufS family,Aminotransferase class-V) b1680(cysteine desulfurase, stimulated by SufE; selenocysteine lyase, PLP-dependent) BN373_27221(cysteine desulfurase) t1241(putative amintransferase) SL1344_1307(putative amintransferase) Cluster1248 1 1 1 1 1 1 1 ROD_13711(cysteine desulfuration protein) ENC_13650(Cysteine desulfuration protein SufE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2202(Cysteine desulfuration protein sufE,cysteine desufuration protein SufE,cysteine desulfurase, sulfur acceptor subunit CsdE,Fe-S metabolism associated domain) b1679(sulfur acceptor protein) BN373_27211(cysteine desulfuration protein SufE) t1242(conserved hypothetical protein) SL1344_1308(conserved hypothetical protein) Cluster1249 1 1 1 1 1 1 1 ROD_13731(major outer membrane lipoprotein (murein-lipoprotein)) ENC_13630(Murein lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2204(Murein-lipoprotein,murein lipoprotein,Repeated sequence found in lipoprotein LPP) b1677(murein lipoprotein) BN373_27191(major outer membrane lipoprotein) t1245(major outer membrane lipoprotein) SL1344_1311(major outer membrane lipoprotein) Cluster1250 1 1 1 1 1 1 1 ROD_13741(pyruvate kinase I) ENC_13620(pyruvate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2205(Pyruvate kinase I,pyruvate kinase,pyruvate kinase,Pyruvate kinase, barrel domain) b1676(pyruvate kinase I) BN373_27181(pyruvate kinase I) t1246(pyruvate kinase) SL1344_1312(pyruvate kinase) Cluster1251 1 1 1 1 1 1 1 ROD_13791(conserved hypothetical protein) ENC_13540(Protein of unknown function (DUF2767).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2206(hypothetical protein,Protein of unknown function (DUF2767)) b1675(predicted protein) BN373_27171(conserved hypothetical protein) t1256(conserved hypothetical protein) SL1344_1322(conserved hypothetical protein) Cluster1252 1 0 1 1 1 2 1 ROD_23291(heme exporter protein D (cytochrome C-type biogenesis protein)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1511(Cytochrome c-type biogenesis protein CcmD,heme exporter protein CcmD,Heme exporter protein D (CcmD)) b2198(cytochrome c biogenesis protein) BN373_26631(heme exporter protein D) t0613(heme exporter protein D1),t3702(heme exporter protein D2) SL1344_3782A(protoheme transport protein D1) Cluster1253 1 0 1 1 1 2 1 ROD_23281(cytochrome C-type biogenesis protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1512(Heme chaperone CcmE,cytochrome c-type biogenesis protein CcmE,ABC-type transport system involved in cytochrome c biogenesis, ATPase component,CcmE) b2197(periplasmic heme chaperone) BN373_26621(cytochrome c-type biogenesis protein CcmE) t0614(cytochrome c-type biogenesis protein E1),t3703(cytochrome c-type biogenesis protein E2) SL1344_2223C(protoheme transport protein) Cluster1254 1 1 1 1 1 1 1 ROD_14061(multidrug resistance protein) ENC_13390(putative efflux protein, MATE family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2218(Multidrug-efflux transporter,multidrug efflux protein,MATE efflux family protein,MatE) b1663(multidrug efflux system transporter) BN373_25841(multidrug resistance protein MdtK) t1293(hypothetical integral membrane protein) SL1344_1357(Probable multidrug resistance protein norM) Cluster1255 1 1 1 1 1 1 1 ROD_14071(riboflavin synthase alpha chain) ENC_13370(riboflavin synthase alpha chain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2219(Riboflavin synthase alpha chain,riboflavin synthase subunit alpha,riboflavin synthase, alpha subunit,Lumazine binding domain) b1662(riboflavin synthase, alpha subunit) BN373_25831(riboflavin synthase, alpha subunit) t1294(riboflavin synthase alpha chain) SL1344_1358(riboflavin synthase alpha chain) Cluster1256 1 1 1 1 1 1 1 ROD_14081(cyclopropane-fatty-acyl-phospholipid synthase) ENC_13360(cyclopropane-fatty-acyl-phospholipid synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2220(Cyclopropane-fatty-acyl-phospholipid synthase,cyclopropane fatty acyl phospholipid synthase,Trans-aconitate methyltransferase,3-demethylubiquinone-9 3-O-methyltransferase,Mycolic acid cyclopropane synthetase) b1661(cyclopropane fatty acyl phospholipid synthase (unsaturated-phospholipid methyltransferase)) BN373_25821(cyclopropane-fatty-acyl-phospholipid synthase) t1295(cyclopropane-fatty-acyl-phospholipid synthase) SL1344_1359(cyclopropane-fatty-acyl-phospholipid synthase) Cluster1257 1 1 1 1 1 1 1 ROD_14101(LysR-family transcriptional regulator) ENC_13340(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2222(HTH-type transcriptional activator AllS,putative DNA-binding transcriptional regulator,transcriptional regulator, ArgP family,LysR substrate binding domain) b1659(predicted DNA-binding transcriptional regulator) BN373_25801(transcriptional regulator, LysR family) t1297(putative transcriptional regulator) SL1344_1361(putative transcriptional regulator) Cluster1258 1 1 1 1 1 1 1 ROD_14111(purine nucleotide synthesis repressor) ENC_13330(transcriptional regulator, LacI family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2223(Purine nucleotide synthesis repressor,DNA-binding transcriptional repressor PurR,ABC-type sugar transport system, periplasmic component,catabolite control protein A,Periplasmic binding proteins and sugar binding domain of LacI family) b1658(DNA-binding transcriptional repressor, hypoxanthine-binding) BN373_25791(transcriptional repressor PurR) t1298(purine nucleotide synthesis repressor) SL1344_1362(purine nucleotide synthesis repressor) Cluster1259 1 1 1 1 1 1 1 ROD_14151(putative exported protein) ENC_13280(Cell wall-associated hydrolases (invasion-associated proteins)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2227(Probable endopeptidase YafL precursor,outer membrane lipoprotein,Uncharacterized protein conserved in bacteria,NlpC/P60 family) b1655(predicted peptidase, C40 clan) BN373_25741(NlpC/P60 family protein) t1300(putative secreted protein) SL1344_1364(putative secreted protein) Cluster1260 1 1 1 1 1 1 1 ROD_14161(conserved hypothetical protein) ENC_13270(glutaredoxin-related protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2228(Monothiol glutaredoxin,glutaredoxin-4,Nucleotide-binding protein implicated in inhibition of septum formation,monothiol glutaredoxin, Grx4 family,Glutaredoxin) b1654(glutaredoxin-4) BN373_25731(putative monothiol glutaredoxin) t1301(conserved hypothetical protein) SL1344_1365(conserved hypothetical protein) Cluster1261 1 1 1 1 1 1 1 ROD_14171(ribonuclease T) ENC_13260(RNAse T) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2229(Ribonuclease T,ribonuclease T,ribonuclease T,Exonuclease) b1652(ribonuclease T (RNase T)) BN373_25721(ribonuclease T) t1302(ribonuclease T) SL1344_1366(ribonuclease T) Cluster1262 1 1 1 1 1 1 1 ROD_14181(lactoylglutathione lyase) ENC_13250(lactoylglutathione lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2230(Lactoylglutathione lyase,glyoxalase I,Predicted enzyme related to lactoylglutathione lyase,lactoylglutathione lyase,Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily) b1651(glyoxalase I, Ni-dependent) BN373_25711(lactoylglutathione lyase) t1303(lactoylglutathione lyase) SL1344_1367(lactoylglutathione lyase) Cluster1263 1 1 1 1 1 1 1 ROD_14191(N-ethylmaleimide reductase) ENC_13240(NADH:flavin oxidoreductases, Old Yellow Enzyme family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2231(N-ethylmaleimide reductase,N-ethylmaleimide reductase,mycofactocin system FadH/OYE family oxidoreductase 2,NADH:flavin oxidoreductase / NADH oxidase family) b1650(N-ethylmaleimide reductase, FMN-linked) BN373_25701(N-ethylmaleimide reductase) t1304(N-ethylmaleimide reductase) SL1344_1368(N-ethylmaleimide reductase) Cluster1264 1 1 1 1 1 1 1 ROD_14201(TetR-family transcriptional regulator) ENC_13230(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2232(HTH-type transcriptional repressor nemR,Bacterial regulatory proteins, tetR family) b1649(transcriptional repressor for the nem operon, NEM-inactivated) BN373_25691(transcriptional regulator, TetR family) t1305(putative TetR-family transcriptional regulator) SL1344_1369(putative TetR-family transcriptional regulator) Cluster1265 1 1 1 1 1 1 1 ROD_14211(putative aldo/keto reductase) ENC_13200(Predicted oxidoreductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2234(Oxidoreductase YdhF,2,5-diketo-D-gluconate reductase B,Predicted oxidoreductase,voltage-dependent potassium channel beta subunit,Aldo/keto reductase family) b1647(predicted oxidoreductase) BN373_25671(oxidoreductase YdhF) t1307(putative oxidoreductase) SL1344_1371(putative oxidoreductase) Cluster1266 1 1 1 1 1 1 1 ROD_14221(superoxide dismutase [Cu-Zn]) ENC_13190(Cu/Zn superoxide dismutase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2235(Superoxide dismutase [Cu-Zn] precursor,superoxide dismutase,Copper/zinc superoxide dismutase (SODC)) b1646(superoxide dismutase, Cu, Zn) BN373_25661(superoxide dismutase (Cu-Zn)) t1308(copper-zinc superoxide dismutase) SL1344_1372(copper-zinc superoxide dismutase) Cluster1267 1 1 1 1 1 1 1 ROD_14231(putative efflux pump protein) ENC_13180(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2236(p-hydroxybenzoic acid efflux pump subunit AaeB,p-hydroxybenzoic acid efflux subunit AaeB,Predicted membrane protein,Fusaric acid resistance protein family) b1645(Efflux protein family (PET) component of predicted YdhJK efflux pump) BN373_25651(fusaric acid resistance domain protein) t1309(putative membrane protein) SL1344_1373(putative membrane protein) Cluster1268 1 1 1 1 1 1 1 ROD_14251(MarR-family transcriptional regulator) ENC_13150(Transcriptional regulators) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2239(Salmolysin,transcriptional regulator SlyA,homoprotocatechuate degradation operon regulator, HpaR,MarR family) b1642(DNA-binding transcriptional activator) BN373_25621(transcriptional regulator SlyA) t1312(transcriptional regulator) SL1344_1376(Transcriptional regulator slyA) Cluster1269 1 1 1 1 1 1 1 ROD_14261(outer membrane lipoprotein) ENC_13120(Outer membrane lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2240(Outer membrane lipoprotein slyB precursor,hypothetical protein,Surface antigen,Glycine zipper 2TM domain) b1641(outer membrane lipoprotein) BN373_25601(outer membrane lipoprotein SlyB) t1313(outer membrane lipoprotein SlyB precursor) SL1344_1377(outer membrane lipoprotein SlyB precursor) Cluster1270 1 1 1 1 1 1 1 ROD_14271(anhydro-N-acetylmuramic acid kinase) ENC_13110(Predicted molecular chaperone distantly related to HSP70-fold metalloproteases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2241(Anhydro-N-acetylmuramic acid kinase,anhydro-N-acetylmuramic acid kinase,Uncharacterised protein family (UPF0075)) b1640(anhydro-N-acetylmuramic acid kinase) BN373_25591(conserved hypothetical protein) t1314(conserved hypothetical protein) SL1344_1378(conserved hypothetical protein) Cluster1271 1 1 1 1 1 1 1 ROD_14281(putative lipoprotein) ENC_13100(Predicted periplasmic protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2242(Membrane-bound lysozyme inhibitor of C-type lysozyme precursor,lysozyme inhibitor,Membrane-bound lysozyme-inhibitor of c-type lysozyme) b1639(inhibitor of c-type lysozyme, membrane-bound; predicted lipoprotein) BN373_25581(putative lipoprotein) t1315(putative lipoprotein) SL1344_1379(lipoprotein) Cluster1272 1 1 1 1 1 1 1 ROD_14291(pyridoxamine 5'-phosphate oxidase) ENC_13090(Pyridoxamine 5'-phosphate oxidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2243(Pyridoxine/pyridoxamine 5'-phosphate oxidase,pyridoxamine 5'-phosphate oxidase,Pyridoxamine-phosphate oxidase,pyridoxamine 5'-phosphate oxidase,Pyridoxamine 5'-phosphate oxidase) b1638(pyridoxine 5'-phosphate oxidase) BN373_25571(pyridoxamine 5'-phosphate oxidase) t1316(pyridoxamine 5'-phosphate oxidase) SL1344_1380(pyridoxamine 5'-phosphate oxidase) Cluster1273 1 1 1 1 1 1 1 ROD_14301(tyrosyl-tRNA synthetase) ENC_13080(tyrosyl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2244(Tyrosine--tRNA ligase,tyrosyl-tRNA synthetase,Tyrosyl-tRNA synthetase,tyrosine--tRNA ligase,tRNA synthetases class I (W and Y)) b1637(tyrosyl-tRNA synthetase) BN373_25561(tyrosyl-tRNA synthetase) t1317(tyrosyl-tRNA synthetase) SL1344_1381(tyrosyl-tRNA synthetase) Cluster1274 1 1 1 1 1 1 1 ROD_14311(pyridoxamine kinase) ENC_13060(Pyridoxal kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2245(Pyridoxamine kinase,pyridoxamine kinase,pyridoxal kinase,Phosphomethylpyrimidine kinase) b1636(pyridoxamine kinase) BN373_25551(pyridoxal kinase) t1318(pyridoxamine kinase) SL1344_1382(pyridoxamine kinase (ec 2.7.1.35) (pm kinase)) Cluster1275 1 1 1 1 1 1 1 ROD_14321(glutathione S-transferase) ENC_13050(Glutathione S-transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2246(Glutathione S-transferase GstA,glutathionine S-transferase,maleylacetoacetate isomerase,Glutathione S-transferase, C-terminal domain) b1635(glutathionine S-transferase) BN373_25541(glutathione S-transferase) t1319(glutathione S-transferase) SL1344_1383(glutathione S-transferase) Cluster1276 1 1 1 1 1 1 1 ROD_14341(endonuclease III) ENC_13030(DNA-(apurinic or apyrimidinic site) lyase /endonuclease III) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2248(Endonuclease III,endonuclease III,3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase,endonuclease III,HhH-GPD superfamily base excision DNA repair protein) b1633(DNA glycosylase and apyrimidinic (AP) lyase (endonuclease III)) BN373_25521(endonuclease III) t1321(endonuclease III) SL1344_1385(endonuclease III) Cluster1277 1 1 1 1 1 1 1 ROD_14351(electron transport complex protein) ENC_13020(electron transport complex, RnfABCDGE type, E subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2249(Electron transport complex protein rnfE,electron transport complex RsxE subunit,Predicted NADH:ubiquinone oxidoreductase, subunit RnfE,electron transport complex, RnfABCDGE type, E subunit,Rnf-Nqr subunit, membrane protein) b1632(electron transport complex inner membrane NADH-quinone reductase required for the reduction of SoxR) BN373_25511(electron transport complex, RnfABCDGE type, E subunit) t1322(conserved hypothetical protein) SL1344_1386(Electron transport complex protein rnfE) Cluster1278 1 1 1 1 1 1 1 ROD_14361(electron transport complex protein) ENC_13010(electron transport complex, RnfABCDGE type, G subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2250(electron transport complex protein RnfG,Predicted NADH:ubiquinone oxidoreductase, subunit RnfG,electron transport complex, RnfABCDGE type, G subunit,FMN-binding domain) b1631(electron transport complex protein required for the reduction of SoxR) BN373_25501(electron transport complex, RnfABCDGE type, G subunit) t1323(conserved hypothetical protein) SL1344_1387(Electron transport complex protein rnfG) Cluster1279 1 1 1 1 1 1 1 ROD_14371(electron transport complex protein) ENC_13000(electron transport complex, RnfABCDGE type, D subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2251(Na(+)-translocating NADH-quinone reductase subunit B,electron transport complex protein RnfD,Predicted NADH:ubiquinone oxidoreductase, subunit RnfD,electron transport complex, RnfABCDGE type, D subunit,NQR2, RnfD, RnfE family) b1630(electron transport complex protein required for the reduction of SoxR; predicted membrane protein) BN373_25491(electron transport complex, RnfABCDGE type, D subunit) t1324(putative membrane protein) SL1344_1388(Electron transport complex protein rnfD) Cluster1280 1 1 1 1 1 1 1 ROD_14381(electron transport complex protein) ENC_12990(electron transport complex, RnfABCDGE type, C subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2252(Nitrogen fixation protein rnfC,electron transport complex protein RnfC,Predicted NADH:ubiquinone oxidoreductase, subunit RnfC,electron transport complex, RnfABCDGE type, C subunit,Respiratory-chain NADH dehydrogenase 51 Kd subunit) b1629(electron transport complex protein required for the reduction of SoxR; predicted membrane-associated NADH oxidoreductase) BN373_25481(electron transport complex protein rnfc) t1325(putative NADH reducing dehydrogenase) SL1344_1389(Electron transport complex protein rnfC) Cluster1281 1 1 1 1 1 1 1 ROD_14391(electron transport complex protein) ENC_12980(electron transport complex, RnfABCDGE type, B subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2253(Nitrogen fixation protein rnfB,electron transport complex protein RnfB,Dihydroorotate dehydrogenase,electron transport complex, RnfABCDGE type, B subunit,Putative Fe-S cluster) b1628(electron transport complex protein, iron-sulfur protein, required for the reduction of SoxR) BN373_25471(electron transport complex, RnfABCDGE type, B subunit) t1326(putative ferredoxin-like protein, cytoplasmic membrane) SL1344_1390(Electron transport complex protein rnfB) Cluster1282 1 1 1 1 1 1 1 ROD_14401(electron transport complex protein) ENC_12970(electron transport complex, RnfABCDGE type, A subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2254(Electron transport complex protein rnfA,electron transport complex protein RsxA,Predicted NADH:ubiquinone oxidoreductase, subunit RnfA,electron transport complex, RnfABCDGE type, A subunit,Rnf-Nqr subunit, membrane protein) b1627(electron transport complex protein required for the reduction of SoxR) BN373_25461(electron transport complex, RnfABCDGE type, A subunit) t1327(putative membrane protein) SL1344_1391(Electron transport complex protein rnfA) Cluster1283 1 1 1 1 1 1 1 ROD_14411(putative outer membrane protein) ENC_12960(Protein of unknown function (DUF2569).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2255(Inner membrane protein ydgK,Protein of unknown function (DUF2569)) b1626(inner membrane protein, DUF2569 family) BN373_25451(putative membrane protein) t1328(putative membrane protein) SL1344_1392(putative membrane protein) Cluster1284 1 1 1 1 1 1 1 ROD_14421(H-NS-and StpA-binding protein) ENC_12950(Haemolysin expression modulating protein.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2256(H-NS/StpA-binding protein 2,oriC-binding nucleoid-associated protein,Haemolysin expression modulating protein) b1625(oriC-binding complex H-NS/Cnu; binds 26 bp cnb site; also forms a complex with StpA) BN373_25441(haemolysin expression modulating protein) t1329(conserved hypothetical protein) SL1344_1393(conserved hypothetical protein) Cluster1285 1 1 1 1 1 1 1 ROD_14461(adenosine deaminase) ENC_12910(adenosine deaminase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2258(Adenine deaminase,adenosine deaminase,Adenosine deaminase,adenosine deaminase,Adenosine/AMP deaminase) b1623(adenosine deaminase) BN373_25401(adenosine deaminase) t1331(adenosine deaminase) SL1344_1395(Adenosine deaminase) Cluster1286 1 1 1 1 1 1 1 ROD_31281(major facilitator superfamily protein) ENC_29290(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1099(Inner membrane transport protein ynfM,putative arabinose transporter,Arabinose efflux permease,MFS transporter, aromatic acid:H+ symporter (AAHS) family,Major Facilitator Superfamily) pseudob2681(unknown) BN373_25391(transporter, major facilitator family) t2709(putative transmembrane transport protein) SL1344_2797(putative transmembrane transport protein) Cluster1287 1 1 1 1 1 1 1 ROD_16211(cytochrome b561 (cytochrome b-561)) ENC_11340(Cytochrome B561) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2399(Cytochrome b-561,cytochrome b561,Uncharacterized conserved protein,Cytochrome b(N-terminal)/b6/petB) b1418(cytochrome b561) BN373_25351(nickel-dependent hydrogenases b-type cytochrome subunit) t1542(putative cytochrome) SL1344_1569(cytochrome b561 (cytochrome b-561)) Cluster1288 1 1 1 1 1 1 1 ROD_16091(glucans biosynthesis protein D) ENC_11110(Periplasmic glucans biosynthesis protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2392(Glucans biosynthesis protein D precursor,glucan biosynthesis protein D,Periplasmic glucans biosynthesis protein,Periplasmic glucan biosynthesis protein, MdoG) b1424(osmoregulated periplasmic glucan (OPG) biosynthesis periplasmic protein) BN373_25251(periplasmic glucan biosynthesis protein, MdoG) t1531(putative exported protein) SL1344_1552(Glucans biosynthesis protein D precursor) Cluster1289 1 1 1 1 1 1 1 ROD_16061(putative transferase) ENC_11080(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2389(glucose-1-phosphate adenylyltransferase) b1428(predicted enzyme) BN373_25231(conserved hypothetical protein) t1519(putative transferase) SL1344_1540(putative transferase) Cluster1290 1 1 1 1 1 1 1 ROD_16051(tellurite resistance protein) ENC_11070(C4-dicarboxylate transporter/malic acid transport protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2388(Tellurite resistance protein tehA,potassium-tellurite ethidium and proflavin transporter,C4-dicarboxylate transporter/malic acid transport protein,C4-dicarboxylate transporter/malic acid transport protein) b1429(potassium-tellurite ethidium and proflavin transporter) BN373_25221(tellurite resistance protein TehA) t1518(tellurite resistance protein TehA) SL1344_1539(tellurite resistance protein TehA) Cluster1291 1 1 1 1 1 1 1 ROD_16041(tellurite resistance protein) ENC_11060(tellurite resistance protein TehB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2387(Tellurite resistance protein TehB,tellurite resistance protein TehB,Uncharacterized protein/domain, possibly involved in tellurite resistance,tellurite resistance protein TehB,Tellurite resistance protein TehB) b1430(tellurite resistance protein, SAM-dependent; predicted S-adenosyl-L-methionine-dependent methyltransferase) BN373_25211(tellurite resistance protein TehB) t1517(tellurite resistance protein TehB) SL1344_1538(tellurite resistance protein TehB) Cluster1292 1 1 1 1 1 1 1 ROD_16031(putative lipoprotein) ENC_11030(Protein of unknown function (DUF3313).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2386(Protein of unknown function (DUF3313)) b1431(lipoprotein) BN373_25201(putative lipoprotein) t1516(putative lipoprotein) SL1344_1537(putative lipoprotein) Cluster1293 1 1 1 1 1 1 1 ROD_15991(putative transcriptional regulator) ENC_10970(Predicted transcriptional regulators) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2384(HTH-type transcriptional regulator sinR,DNA-binding transcriptional repressor PuuR,Predicted transcriptional regulator,transcriptional regulator, y4mF family,Helix-turn-helix) b1434(predicted DNA-binding transcriptional regulator) BN373_25161(DNA-binding protein) t1514(putative DNA-binding protein) SL1344_1535(putative DNA-binding protein) Cluster1294 1 1 1 1 1 1 1 ROD_15981(putative peptidase) ENC_10960(Collagenase and related proteases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2383(Uncharacterized protease yhbU precursor,putative protease,Collagenase and related proteases,Peptidase family U32) b1435(predicted peptidase) BN373_25151(peptidase, U32 family) t1513(putative peptidase) SL1344_1534(putative peptidase) Cluster1295 1 1 1 1 1 1 1 ROD_15971(putative exported protein) ENC_10950(Protein of unknown function (DUF2554).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2382(Protein of unknown function (DUF2554)) b1436(predicted protein) BN373_25126(Protein of unknown function (DUF2554)) t1512(conserved hypothetical protein) SL1344_1533(conserved hypothetical protein) Cluster1296 1 1 1 1 1 1 1 ROD_15951(putative GntR-family transciptional regulator) ENC_09320(transcriptional regulator, GntR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2381(Uncharacterized HTH-type transcriptional regulator ydcR,transcriptional regulatory protein PtsJ,Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase,tyrosine/nicotianamine family aminotransferase,Aminotransferase class I and II) b1439(fused predicted DNA-binding transcriptional regulator/predicted amino transferase) BN373_25071(transcriptional regulator, GntR family/aminotransferase, classes I and II) t1507(putative regulatory protein) SL1344_1529(putative regulatory protein) Cluster1297 1 1 1 1 1 1 1 ROD_15851(conserved hypothetical protein) ENC_09420(Protein of unknown function (DUF2526).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2374(Protein of unknown function (DUF2526)) b1446(predicted protein) BN373_24931(conserved hypothetical protein) t1502(conserved hypothetical protein) SL1344_1523(conserved hypothetical protein) Cluster1298 1 1 1 1 1 1 1 ROD_15841(putative outer membrane protein) ENC_09430(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2373(Inner membrane protein ydcZ,Uncharacterized protein conserved in bacteria,Protein of unknown function, DUF606) b1447(inner membrane protein, DUF606 family) BN373_24921(putative membrane protein) t1501(putative membrane protein) SL1344_1522(putative membrane protein) Cluster1299 1 1 1 1 1 1 1 ROD_15831(putative acetyltransferase) ENC_09440(Sortase and related acyltransferases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2372(N-acyltransferase YncA,putative acetyltransferase,Uncharacterized protein conserved in bacteria,ribosomal-protein-alanine acetyltransferase,Acetyltransferase (GNAT) family) b1448(predicted acyltransferase with acyl-CoA N-acyltransferase domain) BN373_24911(acetyltransferase, GNAT family) t1500(putative acetyltransferase) SL1344_1521(putative acetyltransferase) Cluster1300 1 1 1 1 1 1 1 pseudoROD_15781(TonB-dependent receptor (pseudogene)) ENC_09490(TonB-dependent siderophore receptor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2370(Iron(III) dicitrate transport protein FecA,catecholate siderophore receptor CirA,Outer membrane cobalamin receptor protein,TonB-dependent siderophore receptor,TonB dependent receptor) b1451(predicted iron outer membrane transporter) BN373_24851(TonB-dependent receptor) t1497(probable TonB-dependent receptor) SL1344_1518(probable TonB-dependent receptor YncD precursor) Cluster1301 1 1 1 1 1 1 1 ROD_15771(possible exported protein) ENC_09500(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2369(hypothetical protein,Streptogramin lyase,PQQ-dependent catabolism-associated beta-propeller protein,SMP-30/Gluconolaconase/LRE-like region) b1452(ATP-binding protein, periplasmic, function unknown) BN373_24841(conserved hypothetical protein) t1496(possible ATP-binding protein) SL1344_1517(possible ATP-binding protein) Cluster1302 1 1 1 1 1 1 1 ROD_15741(N-hydroxyarylamine O-acetyltransferase) ENC_09710(Arylamine N-acetyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2365(N-hydroxyarylamine O-acetyltransferase,N-hydroxyarylamine O-acetyltransferase,N-acetyltransferase) b1463(N-hydroxyarylamine O-acetyltransferase) BN373_24651(N-hydroxyarylamine O-acetyltransferase) t1492(N-hydroxyarylamine O-acetyltransferase) SL1344_1513(N-hydroxyarylamine O-acetyltransferase) Cluster1303 1 1 1 1 1 1 1 ROD_15561(NAD-dependent malic enzyme) ENC_09940(NAD-dependent malic enzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2350(NAD-dependent malic enzyme,malate dehydrogenase,Malic enzyme, NAD binding domain) b1479(malate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme)) BN373_24281(malate dehydrogenase (oxaloacetate-decarboxylating)) t1481(NAD-linked malic enzyme) SL1344_1496(NAD-linked malic enzyme; malate oxidoreductase) Cluster1304 1 1 1 1 1 1 1 ROD_15551(stationary-phase-induced ribosome-associated protein (sra) (protein d) (30s ribosomal protein s22)) ENC_09950(SSU ribosomal protein S22P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2349(30S ribosomal protein S22,30S ribosomal subunit S22,30S ribosomal protein subunit S22 family) b1480(Stationary-phase-induced ribosome-associated protein) BN373_24271(30S ribosomal protein, S22 family) t1480(30S ribosomal protein S22) SL1344_1495(30S ribosomal protein S22) Cluster1305 1 1 1 1 1 1 1 ROD_35531(putative short chain dehydrogenase) ENC_10310(Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.703(Uncharacterized oxidoreductase yghA,oxidoreductase,Uncharacterized conserved protein,3-oxoacyl-[acyl-carrier-protein] reductase,short chain dehydrogenase) b3003(predicted oxidoreductase) BN373_24231(oxidoreductase, short chain dehydrogenase/reductase family) t3077(possible oxidoreductase) SL1344_3131(possible oxidoreductase) Cluster1306 1 1 1 1 1 1 1 ROD_15531(peroxiredoxin (osmotically-inducible protein C)) ENC_10010(peroxiredoxin, OsmC subfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2347(Peroxiredoxin osmC,peroxiredoxin, OsmC subfamily,OsmC-like protein) b1482(Lipoyl-dependent Cys-based peroxidase, hydroperoxide resistance; salt-shock inducible membrane protein; peroxiredoxin) BN373_24101(peroxiredoxin OsmC) t1478(osmotically inducible protein C) SL1344_1493(osmotically inducible protein C) Cluster1307 1 1 1 1 1 1 1 ROD_15231(putative membrane protein) ENC_10620(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2326(Predicted membrane protein,Bestrophin, RFP-TM, chloride channel) b1520(predicted inner membrane protein, bestrophin family) BN373_24051(conserved hypothetical protein) t1448(putative membrane protein) SL1344_1457(putative membrane protein) Cluster1308 1 1 1 1 1 1 1 ROD_38001(catalase-peroxidase (hydroperoxidase I)) ENC_01040(catalase/peroxidase HPI) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4558(Catalase-peroxidase,catalase/hydroperoxidase HPI(I),catalase/peroxidase HPI,Peroxidase) b3942(catalase-peroxidase HPI, heme b-containing) BN373_23981(catalase/peroxidase HPI) t3510(catalase) SL1344_4056(catalase (hydroperoxidase I)) Cluster1309 1 1 1 1 1 1 1 ROD_15801(GntR-family transcriptional regulator) ENC_09480(transcriptional regulator, GntR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2371(HTH-type transcriptional regulator mcbR,colanic acid/biofilm transcriptional regulator) b1450(colanic acid and biofilm gene transcriptional regulator, MqsR-controlled) BN373_23631(transcriptional regulator, GntR family) t1498(putative regulatory protein) SL1344_1519(putative regulatory protein) Cluster1310 1 1 1 1 1 1 1 ROD_17141(putative signal transduction protein) ENC_08480(EAL domain./GGDEF domain.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2478(Cyclic di-GMP phosphodiesterase Gmr,RNase II stability modulator,MHYT domain (predicted integral membrane sensor domain),diguanylate cyclase (GGDEF) domain,EAL domain) b1285(cyclic-di-GMP phosphodiesterase; csgD regulator; modulator of Rnase II stability) BN373_22571(sensory box-containing diguanylate cyclase/cyclic diguanylate phosphodiesterase) t1616(conserved hypothetical protein) SL1344_1634(conserved hypothetical protein) Cluster1311 1 1 1 1 1 1 1 ROD_15201(conserved hypothetical protein) ENC_10660(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2323(hypothetical protein) b1523(conserved protein) BN373_22131(conserved hypothetical protein) t1447(conserved hypothetical protein) SL1344_1456(conserved hypothetical protein) Cluster1312 1 1 1 1 1 1 1 ROD_15191(glutaminase 2) ENC_10670(L-glutaminase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2322(Thermolabile glutaminase,glutaminase,glutaminase A,Glutaminase) b1524(glutaminase) BN373_22121(glutaminase) t1446(hypothetical protein) SL1344_1455(probable glutaminase) Cluster1313 1 1 1 1 1 1 1 ROD_15181(putative aldehyde dehydrogenase) ENC_10690(succinate semialdehyde dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2321(Succinate semialdehyde dehydrogenase [NAD(P)+] Sad,putative succinate semialdehyde dehydrogenase,Delta 1-pyrroline-5-carboxylate dehydrogenase,betaine aldehyde dehydrogenase,Aldehyde dehydrogenase family) b1525(succinate semialdehyde dehydrogenase, NAD(P)+-dependent) BN373_22111(aldehyde dehydrogenase (NAD) family protein) t1445(putative aldehyde-dehydrogenase) SL1344_1454(putative oxidoreductase) Cluster1314 1 1 1 1 1 1 1 ROD_15171(LysR-family transcriptional regulator) ENC_10700(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2320(HTH-type transcriptional regulator gltR,DNA-binding transcriptional regulator IlvY,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b1526(predicted DNA-binding transcriptional regulator) BN373_22101(transcriptional regulator, LysR family) t1444(putative regulatory protein) SL1344_1453(putative regulatory protein) Cluster1315 1 1 1 1 1 1 1 ROD_15111(conserved hypothetical protein) ENC_10720(phenazine biosynthesis protein PhzF family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2363(Uncharacterized isomerase yddE,hypothetical protein,Predicted epimerase, PhzC/PhzF homolog,phenazine biosynthesis protein, PhzF family,Phenazine biosynthesis-like protein) b1464(conserved predicted enzyme, PhzC-PhzF family) BN373_21981(phenazine biosynthesis protein PhzF family) t1491(conserved hypothetical protein) SL1344_1512(conserved hypothetical protein) Cluster1316 1 1 1 1 1 1 1 ROD_15091(multiple antibiotic resistance protein) ENC_10760(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2318(hypothetical protein,inner membrane protein,membrane protein, MarC family,MarC family integral membrane protein) b1529(inner membrane protein, UPF0056 family) BN373_21961(multiple antibiotic resistance protein MarC) t1442(putative membrane protein) SL1344_1451(putative membrane protein) Cluster1317 1 1 1 1 1 1 1 ROD_15071(multiple antibiotic resistance regulatory protein) ENC_10790(transcriptional regulator, AraC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2316(Multiple antibiotic resistance protein marA,DNA-binding transcriptional activator MarA,DNA gyrase inhibitor,YSIRK-targeted surface antigen transcriptional regulator,Helix-turn-helix domain) b1531(DNA-binding transcriptional dual activator of multiple antibiotic resistance) BN373_21931(multiple antibiotic resistance protein MarA) t1440(multiple antibiotic resistance protein MarA) SL1344_1449(multiple antibiotic resistance protein MarA) Cluster1318 1 1 1 1 1 1 1 ROD_15061(multiple antibiotic resistance protein) ENC_10800(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2315(hypothetical protein) b1532(predicted protein) BN373_21921(multiple antibiotic resistance protein MarB) t1439(multiple antibiotic resistance protein MarB) SL1344_1448(multiple antibiotic resistance protein MarB) Cluster1319 1 1 1 1 1 1 1 ROD_15041(major facilitator superfamily protein) ENC_10830(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2313(putative transporter,Arabinose efflux permease,multidrug resistance protein,Major Facilitator Superfamily) b1534(predicted transporter) BN373_21901(transporter, major facilitator family) t1437(putative membrane protein) SL1344_1446(putative membrane protein) Cluster1320 1 1 1 1 1 1 1 ROD_14891(dipeptidyl carboxypeptidase II) ENC_11960(peptidyl-dipeptidase Dcp . Metallo peptidase. MEROPS family M03A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2310(Peptidyl-dipeptidase dcp,dipeptidyl carboxypeptidase II,Zn-dependent oligopeptidases,Peptidase family M3) b1538(dipeptidyl carboxypeptidase II) BN373_21481(peptidyl-dipeptidase Dcp) t1433(dipeptidyl carboxypeptidase II) SL1344_1442(dipeptidyl carboxypeptidase II) Cluster1321 1 1 1 1 1 1 1 ROD_14881(NADP-dependent L-serine/L-allo-threonine dehydrogenase) ENC_11970(Short-chain alcohol dehydrogenase of unknown specificity) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2309(NADP-dependent 3-hydroxy acid dehydrogenase YdfG,malonic semialdehyde reductase,Outer membrane receptor for Fe3+-dicitrate,acetoacetyl-CoA reductase,short chain dehydrogenase) b1539(Malonic semialdehyde reductase, NADPH-dependent; L-allo-threonine dehydrogenase, NAD(P)-dependent; also oxidizes L-serine, D-serine, D-threonine and 3-hydroxyisobutyrate) BN373_21471(NADP-dependent l-serine/l-allo-threonine dehydrogenase ydfg) t1432(putative oxidoreductase) SL1344_1441(putative oxidoreductase) Cluster1322 1 1 1 1 1 1 1 ROD_14871(GntR-family transcriptional regulator) ENC_11980(transcriptional regulator, GntR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2308(Uncharacterized HTH-type transcriptional regulator ydfH,transcriptional regulator NanR,Transcriptional regulators,phosphonate utilization associated transcriptional regulator,FCD domain) b1540(predicted DNA-binding transcriptional regulator) BN373_21461(transcriptional regulator, GntR family) t1431(putative regulatory protein) SL1344_1440(putative regulatory protein) Cluster1323 1 1 1 1 1 1 1 ROD_14801(putative exported protein) ENC_12090(Protein of unknown function (DUF1283).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2301(hypothetical protein,hypothetical protein,Protein of unknown function (DUF1283)) b1583(predicted protein) BN373_21411(conserved hypothetical protein) t1424(putative secreted protein) SL1344_1433(putative secreted protein) Cluster1324 1 1 1 1 1 1 1 ROD_14791(spermidine N1-acetyltransferase) ENC_12100(spermine/spermidine N-acetyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2300(Spermidine N(1)-acetyltransferase,spermidine N1-acetyltransferase,Predicted acetyltransferase,pseudaminic acid biosynthesis N-acetyl transferase,Acetyltransferase (GNAT) family) b1584(spermidine N1-acetyltransferase) BN373_21401(acetyltransferase, GNAT family) t1423(spermidine N1-acetyltransferase) SL1344_1432(spermidine N1-acetyltransferase) Cluster1325 1 1 1 1 1 1 1 ROD_14771(anaerobic dimethyl sulfoxide reductase maturation protein (twin-arginine leader-binding protein)) ENC_12170(Uncharacterized component of anaerobic dehydrogenases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2292(Twin-arginine leader-binding protein DmsD,twin-argninine leader-binding protein DmsD,Uncharacterized component of anaerobic dehydrogenases,Nitrate reductase delta subunit) b1591(twin-argninine leader-binding protein for DmsA and TorA) BN373_21341(twin-arginine leader-binding protein DmsD) t1416(conserved hypothetical protein) SL1344_1425(conserved hypothetical protein) Cluster1326 1 1 1 1 1 1 1 ROD_14721(putative dethiobiotin synthetase) ENC_12310(dethiobiotin synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2290(ATP-dependent dethiobiotin synthetase BioD 1,putative dithiobiotin synthetase,dethiobiotin synthase,CobQ/CobB/MinD/ParA nucleotide binding domain) b1593(predicted dethiobiotin synthetase) BN373_21321(putative dethiobiotin synthase) t1410(putative dethiobiotin synthetase) SL1344_1419(Dethiobiotin synthetase) Cluster1327 1 1 1 1 1 1 1 ROD_14701(LysR-family transcriptional regulator) ENC_12330(transcriptional regulator, LysR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2288(Hca operon transcriptional activator,DNA-binding transcriptional activator XapR,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b1595(predicted DNA-binding transcriptional regulator) BN373_21301(transcriptional regulator, LysR family) t1408(putative regulatory protein) SL1344_1417(putative regulatory protein) Cluster1328 1 1 1 1 1 1 1 ROD_14691(major facilitator superfamily protein) ENC_12340(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2287(Inner membrane transport protein ynfM,putative sialic acid transporter,Argininosuccinate lyase,MFS transporter, aromatic acid:H+ symporter (AAHS) family,Major Facilitator Superfamily) b1596(predicted transporter) BN373_21291(transporter, major facilitator family) t1407(putative membrane transport protein) SL1344_1416(putative membrane transport protein) Cluster1329 1 1 1 1 1 1 1 ROD_14652(multidrug efflux system protein MdtJ) ENC_12390(Membrane transporters of cations and cationic drugs) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2283(Spermidine export protein MdtJ,multidrug efflux system protein MdtJ,Membrane transporters of cations and cationic drugs,Small Multidrug Resistance protein) b1600(multidrug efflux system transporter) BN373_21211(multidrug resistance protein MdtJ) t1402(putative conserved membrane protein) SL1344_1412(putative conserved membrane protein) Cluster1330 1 1 1 1 1 1 1 ROD_14641(AI-2 transport protein TqsA) ENC_12400(Predicted permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2282(Transport of quorum-sensing signal protein,pheromone autoinducer 2 transporter,sporulation integral membrane protein YtvI,Domain of unknown function DUF20) b1601(pheromone AI-2 transporter) BN373_21201(inner membrane protein YdgG) t1401(putative membrane protein) SL1344_1411(putative membrane protein) Cluster1331 1 1 1 1 1 1 1 ROD_34881(two-component sensor kinase) ENC_41990(Signal transduction histidine kinase regulating citrate/malate metabolism) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4342(Sensor histidine kinase DcuS,sensory histidine kinase DcuS,Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation,phosphate regulon sensor kinase PhoR,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b4125(sensory histidine kinase in two-component regulatory system with DcuR, regulator of anaerobic fumarate respiration) BN373_21071(sensor protein DcuS) t4211(two-component sensor kinase) SL1344_4241(two-component sensor kinase) Cluster1332 1 1 1 1 1 1 1 ROD_16701(conserved hypothetical protein) ENC_12600(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2426(Probable DNA endonuclease SmrA,hypothetical protein,MutS2 family protein,Smr domain) b1340(DNA endonuclease) BN373_20931(Smr domain protein) t1562(conserved hypothetical protein) SL1344_1589(conserved hypothetical protein) Cluster1333 1 1 1 1 1 1 1 ROD_16711(methylated-DNA-protein-cysteine methyltransferase) ENC_12650(O-6-methylguanine DNA methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2431(Methylated-DNA--protein-cysteine methyltransferase,O-6-alkylguanine-DNA:cysteine-protein methyltransferase,Methylated DNA-protein cysteine methyltransferase,methylated-DNA-[protein]-cysteine S-methyltransferase,6-O-methylguanine DNA methyltransferase, DNA binding domain) b1335(O-6-alkylguanine-DNA:cysteine-protein methyltransferase) BN373_20871(methylated-DNA--protein-cysteine methyltransferase) t1563(O6-methylguanine-DNA-alkyltransferase) SL1344_1590(O6-methylguanine-DNA-alkyltransferase) Cluster1334 1 1 1 1 1 1 1 ROD_16721(fumarate and nitrate reduction regulatory protein) ENC_12660(cAMP-binding proteins-catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2432(Fumarate and nitrate reduction regulatory protein,fumarate/nitrate reduction transcriptional regulator,Predicted signal-transduction protein containing cAMP-binding and CBS domains,global nitrogen regulator NtcA,Cyclic nucleotide-binding domain) b1334(DNA-binding transcriptional dual regulator, global regulator of anaerobic growth) BN373_20861(fumarate and nitrate reduction regulatory protein) t1564(fumarate and nitrate reduction regulatory protein) SL1344_1591(fumarate and nitrate reduction regulatory protein) Cluster1335 1 1 1 1 1 1 1 ROD_16731(universal stress protein E) ENC_12670(Universal stress protein UspA and related nucleotide-binding proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2433(Universal stress protein E,universal stress protein UspE,Universal stress protein family) b1333(stress-induced protein) BN373_20851(universal stress protein E) t1565(conserved hypothetical protein) SL1344_1592(conserved hypothetical protein) Cluster1336 1 1 1 1 1 1 1 ROD_13651(conserved hypothetical protein) ENC_13890(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2195(hypothetical protein) b1685(predicted protein) BN373_20841(conserved hypothetical protein) t1235(conserved hypothetical protein) SL1344_1301(conserved hypothetical protein) Cluster1337 1 1 1 1 1 1 1 ROD_14631(NAD(P) transhydrogenase subunit beta) ENC_12690(NAD/NADP transhydrogenase beta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2281(NAD(P) transhydrogenase subunit beta,pyridine nucleotide transhydrogenase,NAD/NADP transhydrogenase alpha subunit,NAD(P) transhydrogenase beta subunit) b1602(pyridine nucleotide transhydrogenase, beta subunit) BN373_20831(NAD(P) transhydrogenase, beta subunit) t1400(pyridine nucleotide transhydrogenase subunit-beta) SL1344_1410(pyridine nucleotide transhydrogenase subunit-beta) Cluster1338 1 1 1 1 1 1 1 ROD_14621(NAD(P) transhydrogenase subunit alpha) ENC_12700(NAD(P) transhydrogenase, alpha subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2280(NAD(P) transhydrogenase subunit alpha,NAD(P) transhydrogenase subunit alpha,NAD/NADP transhydrogenase alpha subunit,NAD(P)(+) transhydrogenase (AB-specific), alpha subunit,Alanine dehydrogenase/PNT, C-terminal domain) b1603(pyridine nucleotide transhydrogenase, alpha subunit) BN373_20821(NAD(P) transhydrogenase, alpha subunit) t1399(pyridine nucleotide transhydrogenase subunit-alpha) SL1344_1409(pyridine nucleotide transhydrogenase subunit-alpha) Cluster1339 1 1 1 1 1 1 1 ROD_14601(putative exported protein) ENC_12710(Protein of unknown function (DUF1471).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2279(hypothetical protein,putative biofilm stress and motility protein A,Protein of unknown function (DUF1471)) b1604(predicted protein) BN373_20811(conserved hypothetical protein) t1398(putative exported protein) SL1344_1408(putative exported protein) Cluster1340 1 1 1 1 1 1 1 ROD_14591(putative arginine/ornithine antiporter) ENC_12720(arginine/ornithine antiporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2278(Putative arginine/ornithine antiporter,arginine:agmatin antiporter,transporter, basic amino acid/polyamine antiporter (APA) family) b1605(predicted arginine/ornithine antiporter transporter) BN373_20801(arginine/ornithine antiporter) t1345(putative amino acid permease) SL1344_1407(putative amino acid permease) Cluster1341 1 1 1 1 1 1 1 ROD_14571(putative outer membrane protein) ENC_12740(Uncharacterized membrane protein required for alginate biosynthesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2276(Inner membrane protein ydgC,Uncharacterized membrane protein required for alginate biosynthesis,GlpM protein) b1607(inner membrane protein, GlpM family) BN373_20781(putative membrane protein) t1344(putative membrane protein) SL1344_1406(putative membrane protein) Cluster1342 1 1 1 1 1 1 1 ROD_14561(two-component response regulator) ENC_12750(Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2275(Transcriptional regulatory protein RstA,DNA-binding transcriptional regulator RstA,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Transcriptional regulatory protein, C terminal) b1608(multicopy supressor of yjeE, yeaZ or ygjD deletion lethality, predicted response regulator of two-component regulatory system with sensor protein RstB) BN373_20771(transcriptional regulatory protein RstA) t1343(putative two-component response regulator) SL1344_1405(putative two-component response regulator) Cluster1343 1 1 1 1 1 1 1 ROD_14541(DNA replication terminus site-binding protein) ENC_12820(DNA replication terminus site binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2273(DNA replication terminus site-binding protein,DNA replication terminus site-binding protein,DNA replication terminus site-binding protein,DNA replication terminus site-binding protein (Ter protein)) b1610(inhibitor of replication at Ter, DNA-binding protein) BN373_20741(DNA replication terminus site-binding protein) t1338(DNA replication terminus site-binding protein) SL1344_1401(DNA replication terminus site-binding protein) Cluster1344 1 1 1 1 1 1 1 ROD_14531(fumarate hydratase class II) ENC_12830(fumarase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2272(Fumarate hydratase class II,fumarate hydratase,Fumarase,fumarate hydratase, class II,Lyase) b1611(fumarate hydratase (fumarase C),aerobic Class II) BN373_20731(fumarate hydratase) t1337(fumarate hydratase class II) SL1344_1400(Fumarate hydratase class II) Cluster1345 1 1 1 1 1 1 1 ROD_14511(mannose-6-phosphate isomerase) ENC_12850(mannose-6-phosphate isomerase, type 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2270(Mannose-6-phosphate isomerase,mannose-6-phosphate isomerase,mannose-6-phosphate isomerase, class I,Phosphomannose isomerase type I) b1613(mannose-6-phosphate isomerase) BN373_20711(mannose-6-phosphate isomerase, class I) t1335(mannose-6-phosphate isomerase) SL1344_1397(mannose-6-phosphate isomerase) Cluster1346 1 1 1 1 1 1 1 ROD_14501(putative exported protein) ENC_12860(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2269(hypothetical protein,hypothetical protein,Bacterial protein of unknown function (DUF945)) b1614(conserved protein, DUF945 family) BN373_20701(conserved hypothetical protein) t1334(conserved hypothetical protein) SL1344_1396(conserved hypothetical protein) Cluster1347 1 1 1 1 1 1 1 ROD_14471(protein MalY) ENC_12900(Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2259(hypothetical protein,aspartate aminotransferase,Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase,tyrosine/nicotianamine family aminotransferase,Aminotransferase class I and II) b1622(bifunctional beta-cystathionase, PLP-dependent/ regulator of maltose regulon) BN373_20671(MalY protein) t1470(putative aminotransferase) SL1344_1487(putative aminotransferase) Cluster1348 1 1 1 1 1 1 1 ROD_14861(conserved hypothetical protein) ENC_12000(putative selenium-binding protein YdfZ) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2307(Putative selenoprotein ydfZ,putative selenium-binding protein YdfZ) b1541(selenoprotein, function unknown) BN373_20651(conserved hypothetical protein) t1430(conserved hypothetical protein) SL1344_1439(conserved hypothetical protein) Cluster1349 1 1 1 1 1 1 1 ROD_20131(putative membrane protein) ENC_08190(Predicted transporter component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1894(hypothetical protein,putative inner membrane protein,Predicted transporter component,YeeE/YedE family (DUF395)) b1929(predicted inner membrane protein) BN373_20621(putative membrane protein) t0912(putative membrane protein) SL1344_1894(putative membrane protein) Cluster1350 1 1 1 1 1 1 1 ROD_20141(conserved hypothetical protein) ENC_08180(Predicted redox protein, regulator of disulfide bond formation) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1893(hypothetical protein,hypothetical protein,Predicted transporter component,SirA-like protein) b1930(conserved protein, UPF0033 family) BN373_20611(conserved hypothetical protein) t0911(conserved hypothetical protein) SL1344_1895(conserved hypothetical protein) Cluster1351 1 1 1 1 1 1 1 ROD_31421(putative membrane protein) ENC_29160(Uncharacterized homolog of Blt101) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1113(Uncharacterized homolog of Blt101,Proteolipid membrane potential modulator) b2666(regulated by cyaR sRNA, UPF0057 family; predicted membrane protein) BN373_20591(conserved hypothetical protein) t2691(conserved hypothetical protein) SL1344_2780(conserved hypothetical protein) Cluster1352 1 1 1 1 1 1 1 ROD_16241(conserved hypothetical protein) ENC_11360(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2402(hypothetical protein,DUF218 domain) b1414(conserved SAM-binding protein, DUF218 superfamily) BN373_20561(conserved hypothetical protein) t1543(conserved hypothetical protein) SL1344_1570(conserved hypothetical protein) Cluster1353 1 1 1 1 1 1 1 ROD_16281(FMN-dependent NADH-azoreductase) ENC_11440(Acyl carrier protein phosphodiesterase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2404(FMN-dependent NADH-azoreductase,azoreductase,Putative NADPH-quinone reductase (modulator of drug activity B),Flavodoxin-like fold) b1412(NADH-azoreductase, FMN-dependent) BN373_20381(FMN-dependent NADH-azoreductase) t1545(acyl carrier protein phosphodiesterase) SL1344_1572(Acyl carrier protein phosphodiesterase) Cluster1354 0 1 1 2 1 1 1 ENC_11570(phenylacetic acid degradation protein PaaY) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3958(hypothetical protein,carnitine operon protein CaiE,Acetyltransferase (isoleucine patch superfamily),phenylacetic acid degradation protein PaaY,Bacterial transferase hexapeptide (six repeats)) b0035(stimulator of CaiD and CaiB enzyme activities),b1400(predicted hexapeptide repeat acetyltransferase) BN373_20361(phenylacetic acid degradation protein PaaY) t0070(carnitine operon protein CaiE) SL1344_0070(carnitine operon protein CaiE) Cluster1355 1 1 1 1 1 1 1 ROD_16361(putative exported protein) ENC_11800(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2409(Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF1318)) b1383(conserved protein) BN373_20071(conserved hypothetical protein) t1547(putative secreted protein) SL1344_1574(putative secreted protein) Cluster1356 1 1 1 1 1 1 1 ROD_16411(heat shock protein) ENC_09270(Heat shock protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2413(Heat shock protein hslJ,heat-inducible protein,META domain) b1379(heat-inducible lipoprotein involved in novobiocin resistance) BN373_20021(heat shock protein HslJ) t1551(heat shock protein) SL1344_1578(heat shock protein (hslJ)) Cluster1357 1 1 1 1 1 1 1 ROD_16441(probable pyruvate-flavodoxin oxidoreductase) ENC_09260(Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2415(Pyruvate synthase subunit porA,pyruvate flavodoxin oxidoreductase subunit alpha,Sulfite reductase, beta subunit (hemoprotein),pyruvate:ferredoxin (flavodoxin) oxidoreductase,domain) b1378(fused predicted pyruvate-flavodoxin oxidoreductase: conserved protein/conserved protein/FeS binding protein) BN373_20001(putative pyruvate:ferredoxin (flavodoxin) oxidoreductase) t1553(probable pyruvate-flavodoxin oxidoreductase) SL1344_1581(probable pyruvate-flavodoxin oxidoreductase) Cluster1358 1 1 1 1 1 1 1 ROD_16461(outer membrane protein N (porin)) ENC_09240(Outer membrane protein (porin)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2417(Porin OmpN,outer membrane porin protein C,Outer membrane protein (porin),Gram-negative porin) b1377(outer membrane pore protein N, non-specific) BN373_19991(outer membrane protein N) t1341(outer membrane protein) SL1344_1404(outer membrane protein) Cluster1359 1 1 1 1 1 1 1 ROD_16581(tRNA 2-thiocytidine biosynthesis protein ttcA) ENC_09200(tRNA s(2)C-32 sulfurtransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2420(tRNA 2-thiocytidine biosynthesis protein TtcA,tRNA 2-thiocytidine biosynthesis protein TtcA,Predicted ATPase of the PP-loop superfamily implicated in cell cycle control,tRNA(Ile)-lysidine synthetase,PP-loop family) b1344(tRNA 2-thiocytidine biosynthesis protein) BN373_19961(PP-loop family protein) t1558(conserved hypothetical protein) SL1344_1585(conserved hypothetical protein) Cluster1360 1 1 1 1 1 1 1 ROD_16761(putative carboxypeptidase) ENC_08870(Predicted carboxypeptidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2440(murein peptide amidase A,Zinc carboxypeptidase) b1326(murein peptide amidase A) BN373_19361(zinc carboxypeptidase family protein) t1584(conserved hypothetical protein) SL1344_1610(conserved hypothetical protein) Cluster1361 1 1 1 1 1 1 1 ROD_16771(putative mandelate racemase/muconate lactonizing family protein) ENC_08860(L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2441(L-Ala-D/L-Glu epimerase,L-Ala-D/L-Glu epimerase,L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily,o-succinylbenzoate synthase,Mandelate racemase / muconate lactonizing enzyme, N-terminal domain) b1325(L-Ala-D/L-Glu epimerase) BN373_19351(mandelate racemase/muconate lactonizing enzyme family protein) t1585(putative mandelate racemase) SL1344_1611(putative mandelate racemase / muconate lactonizing enzyme family protein) Cluster1362 1 1 1 1 1 1 1 ROD_16781(thiol peroxidase) ENC_08850(thiol peroxidase (atypical 2-Cys peroxiredoxin)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2442(Thiol peroxidase,lipid hydroperoxide peroxidase,Redoxin) b1324(lipid hydroperoxide peroxidase) BN373_19341(thiol peroxidase) t1586(thiol peroxidase) SL1344_1612(Probable thiol peroxidase) Cluster1363 1 1 1 1 1 1 1 ROD_16791(transcriptional regulator) ENC_08840(Transcriptional regulator of aromatic amino acids metabolism) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2443(Transcriptional regulatory protein tyrR,DNA-binding transcriptional regulator TyrR,Transcriptional regulator of aromatic amino acids metabolism,Nif-specific regulatory protein,Sigma-54 interaction domain) b1323(DNA-binding transcriptional dual regulator, tyrosine-binding) BN373_19321(transcriptional regulatory protein TyrR) t1588(transcriptional regulatory protein TyrR) SL1344_1613(transcriptional regulatory protein TyrR) Cluster1364 1 1 1 1 1 1 1 ROD_16801(putative membrane protein) ENC_08830(conserved hypothetical protein, TIGR01620) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2444(hypothetical protein,hypothetical protein,conserved hypothetical protein,Domain of unknown function (DUF697)) b1322(inner membrane protein, UPF0283 family) BN373_19291(conserved hypothetical protein TIGR01620) t1589(putative membrane protein) SL1344_1614(putative membrane protein) Cluster1365 1 1 1 1 1 1 1 ROD_17011(phage shock protein D) ENC_08680(phage shock protein PspD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2459(peripheral inner membrane phage-shock protein,phage shock protein PspD,Phage shock protein PspD (Phageshock_PspD)) b1307(peripheral inner membrane phage-shock protein) BN373_19271(phage shock protein D) t1592(phage shock protein D) SL1344_1617(bacteriophage shock protein D) Cluster1366 1 1 1 1 1 1 1 ROD_17021(phage shock protein C) ENC_08670(phage shock protein C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2460(Phage shock protein C,DNA-binding transcriptional activator PspC,phage shock protein C,PspC domain) b1306(DNA-binding transcriptional activator) BN373_19261(phage shock protein C) t1593(phage shock protein C) SL1344_1618(bacteriophage shock protein C) Cluster1367 1 1 1 1 1 1 1 ROD_17031(phage shock protein B) ENC_08660(phage shock protein B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2461(Phage shock protein B,phage shock protein B,phage shock protein B,Phage shock protein B) b1305(DNA-binding transcriptional regulator of psp operon) BN373_19251(phage shock protein B) t1594(phage shock protein B) SL1344_1619(bacteriophage shock protein B) Cluster1368 1 1 1 1 1 1 1 ROD_17041(phage shock protein A) ENC_08650(phage shock protein A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2462(Phage shock protein A,phage shock protein PspA,phage shock protein A,PspA/IM30 family) b1304(regulatory protein for phage-shock-protein operon) BN373_19241(phage shock protein A) t1595(phage shock protein A) SL1344_1620(bacteriophage shock protein A) Cluster1369 1 1 1 1 1 1 1 ROD_17051(Psp operon transcriptional activator) ENC_08640(psp operon transcriptional activator PspF) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2463(Phage shock protein F,phage shock protein operon transcriptional activator,Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,psp operon transcriptional activator,Sigma-54 interaction domain) b1303(DNA-binding transcriptional activator) BN373_19231(psp operon transcriptional activator) t1596(psp operon transcriptional activator PspF) SL1344_1621(psp operon transcriptional activator PspF) Cluster1370 1 1 1 1 1 1 1 ROD_17081(peptide ABC transporter, permease protein) ENC_08610(ABC-type antimicrobial peptide transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2467(Peptide transport system permease protein sapC,antimicrobial peptide ABC transporter permease SapC,ABC-type antimicrobial peptide transport system, permease component,nickel ABC transporter, permease subunit NikC,Binding-protein-dependent transport system inner membrane component) b1292(antimicrobial peptide transport ABC transporter permease) BN373_19151(peptide ABC transporter, permease protein SapC) t1608(peptide transport system permease protein SapC) SL1344_1624(peptide transport system permease protein SapC) Cluster1371 1 1 1 1 1 1 1 ROD_17091(peptide ABC transporter, ATP-binding protein) ENC_08600(oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2468(Glutathione import ATP-binding protein GsiA,antimicrobial peptide ABC transporter ATP-binding protein,ABC-type oligopeptide transport system, ATPase component,nickel import ATP-binding protein NikD,ABC transporter) b1291(antimicrobial peptide transport ABC system ATP-binding protein) BN373_19141(peptide ABC transporter, ATP-binding protein SapD) t1609(peptide transport system ATP-binding protein SapD) SL1344_1625(peptide transport system ATP-binding protein SapD) Cluster1372 1 1 1 1 1 1 1 ROD_17101(peptide ABC transporter, ATP-binding protein) ENC_08590(ABC-type antimicrobial peptide transport system, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2469(Glutathione import ATP-binding protein GsiA,antimicrobial peptide ABC system ATP-binding protein SapF,ABC-type antimicrobial peptide transport system, ATPase component,nickel import ATP-binding protein NikE,ABC transporter) b1290(antimicrobial peptide transport ABC system ATP-binding protein) BN373_19131(peptide ABC transporter, ATP-binding protein SapF) t1610(peptide transport system ATP-binding protein SapF) SL1344_1626(peptide transport system ATP-binding protein SapF) Cluster1373 1 1 1 1 1 1 1 ROD_17111(enoyl-[acyl-carrier-protein] reductase (NADH)) ENC_08530(Enoyl-[acyl-carrier-protein] reductase [NADH]) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2475(Enoyl-[acyl-carrier-protein] reductase [NADH] FabI,enoyl-(acyl carrier protein) reductase,Uncharacterized conserved protein,3-oxoacyl-[acyl-carrier-protein] reductase,short chain dehydrogenase) b1288(enoyl-[acyl-carrier-protein] reductase, NADH-dependent) BN373_19101(enoyl-(acyl-carrier-protein) reductase (NADH)) t1613(enoyl-[acyl-carrier-protein] reductase (NADH)) SL1344_1631(enoyl-[acyl-carrier-protein] reductase (NADH)) Cluster1374 1 1 1 1 1 1 1 ROD_17121(conserved hypothetical protein) ENC_08520(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2476(Uncharacterized protein conserved in bacteria,uncharacterized peroxidase-related enzyme) b1287(predicted oxidoreductase) BN373_19091(conserved hypothetical protein) t1614(conserved hypothetical protein) SL1344_1632(conserved hypothetical protein) Cluster1375 1 1 1 1 1 1 1 ROD_17161(DeoR-family transcriptional regulator) ENC_08440(Transcriptional regulators of sugar metabolism) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2480(Glycerol-3-phosphate regulon repressor,DNA-binding transcriptional regulator AgaR,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,CRISPR locus-related DNA-binding protein,Bacterial regulatory proteins, deoR family) b1284(global regulator of transcription; DeoR family) BN373_19061(transcriptional regulator, DeoR family) t1617(putative regulatory protein) SL1344_1636(putative regulatory protein) Cluster1376 1 1 1 1 1 1 1 ROD_17181(putative translation initiaiton factor) ENC_08430(translation initiation factor 1 (eIF-1/SUI1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2482(hypothetical protein,translation initiation factor Sui1,putative translation initiation factor SUI1,Translation initiation factor SUI1) b1282(initiation factor function partial mimic, SUI1 family) BN373_19041(putative translation initation factor SUI1) t1619(putative translation initiaiton factor) SL1344_1638(putative translation initiaiton factor) Cluster1377 1 1 1 1 1 1 1 ROD_17191(orotidine 5'-phosphate decarboxylase) ENC_08420(orotidine-5'-phosphate decarboxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2483(Orotidine 5'-phosphate decarboxylase,orotidine 5'-phosphate decarboxylase,Orotidine-5'-phosphate decarboxylase,orotidine 5'-phosphate decarboxylase,Orotidine 5'-phosphate decarboxylase / HUMPS family) b1281(orotidine-5'-phosphate decarboxylase) BN373_19031(orotidine 5'-phosphate decarboxylase) t1620(orotidine-5'-P decarboxylase) SL1344_1639(Orotidine 5'-phosphate decarboxylase) Cluster1378 1 1 1 1 1 1 1 ROD_17221(phosphatidylglycerophosphatase B) ENC_08390(phosphatidylglycerophosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2486(Phosphatidylglycerophosphatase B,phosphatidylglycerophosphatase B,PAP2 (acid phosphatase) superfamily protein,PAP2 superfamily) b1278(phosphatidylglycerophosphatase B) BN373_19001(phosphatidylglycerophosphatase B) t1623(phosphatidylglycerophosphatase B) SL1344_1642(phosphatidylglycerophosphatase B) Cluster1379 1 1 1 1 1 1 1 ROD_17231(GTP cyclohydrolase II) ENC_08380(GTP cyclohydrolase II) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2487(GTP cyclohydrolase-2,GTP cyclohydrolase II,GTP cyclohydrolase II,GTP cyclohydrolase II) b1277(GTP cyclohydrolase II) BN373_18991(GTP cyclohydrolase II) t1624(GTP cyclohydrolase II) SL1344_1643(GTP cyclohydrolase II) Cluster1380 2 0 1 1 1 1 1 ROD_12451(putative aconitate hydratase),ROD_17241(aconitate hydratase 1 (citrate hydro-lyase 1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2488(Aconitate hydratase 1,aconitate hydratase,3-isopropylmalate dehydratase large subunit,aconitate hydratase 1,Aconitase family (aconitate hydratase)) b1276(aconitate hydratase 1) BN373_18981(aconitate hydratase 1) t1625(aconitate hydratase 1) SL1344_1644(aconitate hydratase 1 (citrate hydro-lyase 1)) Cluster1381 1 1 1 1 1 1 1 ROD_17281(Cys regulon transcriptional activator) ENC_08340(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2492(Cys regulon transcriptional activator,transcriptional regulator CysB,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b1275(DNA-binding transcriptional dual regulator, O-acetyl-L-serine-binding) BN373_18961(transcriptional regulator CysB) t1626(cys regulon transcriptional activator) SL1344_1645(cys regulon transcriptional activator) Cluster1382 1 1 1 1 1 1 1 ROD_17291(DNA topoisomerase I (omega protein)) ENC_08330(DNA topoisomerase I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2493(DNA topoisomerase 1,DNA topoisomerase I subunit omega,Zn-finger domain associated with topoisomerase type I,DNA topoisomerase I,DNA topoisomerase) b1274(DNA topoisomerase I, omega subunit) BN373_18951(DNA topoisomerase I) t1627(DNA topoisomerase I, omega protein I) SL1344_1646(DNA topoisomerase I, omega protein I) Cluster1383 1 1 1 1 1 1 1 ROD_17341(cob(I)yrinic acid a,c-diamide adenosyltransferase) ENC_08290(cob(I)yrinic acid a,c-diamide adenosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2497(Cob(I)yrinic acid a,c-diamide adenosyltransferase,cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase,Ferredoxin,cob(I)yrinic acid a,c-diamide adenosyltransferase,ATP:corrinoid adenosyltransferase BtuR/CobO/CobP) b1270(cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase) BN373_18891(cob(I)yrinic acid a,c-diamide adenosyltransferase) t1631(COB(I) alamin adenosyltransferase) SL1344_1650(COB(I) alamin adenosyltransferase) Cluster1384 1 1 1 1 1 1 1 ROD_17371(conserved hypothetical protein) ENC_08270(Sua5/YciO/YrdC/YwlC family protein) Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.31(hypothetical protein,hypothetical protein,Putative translation factor (SUA5),Sua5/YciO/YrdC/YwlC family protein,yrdC domain) b1267(predicted RNA binding protein) BN373_18851(Sua5/YciO/YrdC/YwlC family protein) t1633(conserved hypothetical protein) SL1344_1652(conserved hypothetical protein) Cluster1385 1 0 2 1 1 1 1 ROD_17381(putative phosphoesterase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2503(hypothetical protein,Histidinol phosphatase and related hydrolases of the PHP family,PHP domain),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.30(hypothetical protein,Histidinol phosphatase and related hydrolases of the PHP family,PHP domain) b1266(conserved protein) BN373_18841(putative phosphoesterase) t1634(conserved hypothetical protein) SL1344_1653(conserved hypothetical protein) Cluster1386 1 1 1 1 1 1 1 ROD_17491(outer membrane protein W) ENC_08170(Outer membrane protein W) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2582(Outer membrane protein W precursor,outer membrane protein W,Outer membrane protein W,OmpW family) b1256(outer membrane protein W) BN373_18711(outer membrane protein W) t1644(putative outer membrane protein) SL1344_1663(putative outer membrane protein) Cluster1387 1 1 1 1 1 1 1 ROD_17501(putative outer membrane protein) ENC_08160(Uncharacterised protein family (UPF0259).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2583(hypothetical protein,hypothetical protein,Uncharacterised protein family (UPF0259)) b1255(inner membrane protein, UPF0259 family) BN373_18691(putative membrane protein) t1646(putative membrane protein) SL1344_1665(putative membrane protein) Cluster1388 1 1 1 1 1 1 1 ROD_17511(putative intracellular septation protein) ENC_08150(intracellular septation protein A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2584(Probable intracellular septation protein A,intracellular septation protein A,Predicted membrane protein,intracellular septation protein A,Intracellular septation protein A) b1254(predicted inner membrane protein) BN373_18681(intracellular septation protein A) t1647(putative intracellular septation protein) SL1344_1666(Probable intracellular septation protein) Cluster1389 1 1 1 1 1 1 1 ROD_17551(putative acyl-coA thioester hydrolase) ENC_08120(Acyl-CoA hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2585(Uncharacterized acyl-CoA thioester hydrolase HI_0827,acyl-CoA esterase,Uncharacterized protein, possibly involved in aromatic compounds catabolism,Thioesterase superfamily) b1253(Acyl-CoA esterase, role unknown) BN373_18661(acyl-CoA thioester hydrolase YciA) t1648(putative acyl-coA hydrolase) SL1344_1667(putative acyl-coA hydrolase) Cluster1390 1 1 1 1 1 1 1 ROD_13301(putative membrane protein) ENC_14260(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2153(hypothetical protein) b1726(predicted inner membrane protein) BN373_18651(conserved hypothetical protein) t1203(putative membrane protein) SL1344_1258(putative membrane protein) Cluster1391 1 1 1 1 1 1 1 ROD_13291(putative phosphatase) ENC_14270(haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2152(Phosphatase YniC,2-deoxyglucose-6-phosphatase,beta-phosphoglucomutase family hydrolase,haloacid dehalogenase-like hydrolase) b1727(2-deoxyglucose-6-P phosphatase) BN373_18641(HAD-superfamily hydrolase, subfamily IA, variant 3) t1202(putative hydrolase) SL1344_1257(putative hydrolase) Cluster1392 1 1 1 1 1 1 1 ROD_13271(putative membrane-bound metal-dependent hydrolase) ENC_14290(Predicted membrane-bound metal-dependent hydrolases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2151(Inner membrane protein ydjM,inner membrane protein,Predicted membrane-bound metal-dependent hydrolase (DUF457)) b1728(inner membrane protein regulated by LexA) BN373_18621(putative metal-dependent hydrolase, membrane-bound) t1201(conserved hypothetical protein) SL1344_1256(conserved hypothetical protein) Cluster1393 1 1 1 1 1 1 1 ROD_13261(putative sodium:dicarboxylate symporter) ENC_14300(Predicted Na+/dicarboxylate symporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2150(Transporter of cystine tcyP,glutamate/aspartate:proton symporter,Sodium:dicarboxylate symporter family) b1729(predicted transporter) BN373_18611(transporter, dicarboxylate/amino acid:cation (Na+ or H+) symporter (DAACS) family) t1200(putative sodium:dicarboxylate symporter) SL1344_1255(putative sodium:dicarboxylate symporter) Cluster1394 1 1 1 1 1 1 1 ROD_13251(cell division activator) ENC_14310(cell division activator CedA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2149(Cell division activator CedA,cell division modulator,Cell division activator CedA) b1731(cell division modulator) BN373_18601(cell division activator cedA) t1199(cell division activator CedA) SL1344_1254(cell division activator CedA) Cluster1395 1 1 1 1 1 1 1 ROD_13241(catalase HPII) ENC_14320(Catalase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2148(Catalase HPII,hydroperoxidase II,Catalase) b1732(catalase HPII, heme d-containing) BN373_18591(catalase HPII) t1198(catalase HPII) SL1344_1253(catalase HPII) Cluster1396 1 1 1 1 1 1 1 ROD_13231(putative chitobiose-phosphate hydrolase) ENC_14330(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2147(hypothetical protein,hypothetical protein,Uncharacterized protein conserved in bacteria,hopanoid biosynthesis associated protein HpnK,YdjC-like protein) b1733(UPF0249 family protein) BN373_18581(conserved hypothetical protein) t1196(conserved hypothetical protein) SL1344_1252(conserved hypothetical protein) Cluster1397 1 1 1 1 1 1 1 ROD_13211(chb operon repressor) ENC_14350(transcriptional regulator, AraC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2145(Chb operon repressor,DNA-binding transcriptional regulator ChbR,Adenosine deaminase,4-hydroxyphenylacetate catabolism regulatory protein HpaA,Helix-turn-helix domain) b1735(rRepressor, chb operon for N,N'-diacetylchitobiose utilization) BN373_18561(transcriptional regulator ChbR) t1194(putative cel operon repressor) SL1344_1250(putative cel operon repressor) Cluster1398 1 1 1 1 1 1 1 ROD_13201(N,N'-diacetylchitobiose-specific PTS system, EIIA component) ENC_14360(PTS system N,N'-diacetylchitobiose-specific IIA component, Lac family (TC 4.A.3.2.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2144(N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA component,PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA,PTS system, lactose-specific IIa component,PTS system, Lactose/Cellobiose specific IIA subunit) b1736(N,N'-diacetylchitobiose-specific enzyme IIA component of PTS) BN373_18551(PTS system, N,N'-diacetylchitobiose-specific EIIA component) t1193(phosphoenolpyruvate dependent phosphotransferase enzyme III-cellobiose) SL1344_1249(phosphoenolpyruvate dependent phosphotransferase enzyme III-cellobiose) Cluster1399 1 1 1 1 1 1 1 ROD_13181(N,N'-diacetylchitobiose-specific PTS syetem, EIIB component) ENC_14380(PTS system N,N'-diacetylchitobiose-specific IIB component, Lac family (TC 4.A.3.2.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2142(N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIB component,PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB,Phosphotransferase system cellobiose-specific component IIB,PTS system, lactose/cellobiose family IIB component,PTS system, Lactose/Cellobiose specific IIB subunit) b1738(N,N'-diacetylchitobiose-specific enzyme IIB component of PTS) BN373_18531(PTS system, N,N'-diacetylchitobiose-specific IIB component) t1191(cellobiose-specific IIB component of PTS system) SL1344_1247(PTS system, cellobiose-specific IIB component) Cluster1400 1 1 1 1 1 1 1 ROD_13151(excinuclease Cho) ENC_14390(Excinuclease Cho) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2139(Excinuclease cho,nucleotide excision repair endonuclease,Nuclease subunit of the excinuclease complex,excinuclease ABC subunit C) b1741(endonuclease of nucleotide excision repair) BN373_18501(excinuclease cho) t1188(conserved hypothetical protein) SL1344_1244(conserved hypothetical protein) Cluster1401 1 1 1 1 1 1 1 ROD_13141(spheroplast protein Y) ENC_14410(P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2137(Spheroplast protein Y precursor,periplasmic protein,P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein,LTXXQ motif) b1743(periplasmic ATP-independent protein refolding chaperone, stress-induced) BN373_18491(spheroplast protein Y) t1187(putative exported protein) SL1344_1243(putative exported protein) Cluster1402 1 1 1 1 1 1 1 ROD_13131(succinylglutamate desuccinylase) ENC_14420(succinylglutamate desuccinylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2136(Succinylglutamate desuccinylase,succinylglutamate desuccinylase,succinylglutamate desuccinylase,Succinylglutamate desuccinylase / Aspartoacylase family) b1744(succinylglutamate desuccinylase) BN373_18481(succinylglutamate desuccinylase) t1186(succinylglutamate desuccinylase) SL1344_1242(Succinylglutamate desuccinylase) Cluster1403 1 0 1 1 2 1 1 ROD_13111(N-succinylglutamate 5-semialdehyde dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2134(N-succinylglutamate 5-semialdehyde dehydrogenase,succinylglutamic semialdehyde dehydrogenase,Delta 1-pyrroline-5-carboxylate dehydrogenase,succinylglutamic semialdehyde dehydrogenase,Aldehyde dehydrogenase family) b1746(succinylglutamic semialdehyde dehydrogenase) BN373_18461(succinylglutamic semialdehyde dehydrogenase),BN373_20511(putative succinylglutamic semialdehyde dehydrogenase) t1184(succinylglutamic semialdehyde dehydrogenase) SL1344_1240(succinylglutamic semialdehyde dehydrogenase) Cluster1404 1 1 1 1 1 1 1 ROD_13071(exodeoxyribonuclease III) ENC_14480(Exodeoxyribonuclease III) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2131(Exodeoxyribonuclease III,exonuclease III,Uncharacterized protein conserved in bacteria,exodeoxyribonuclease III,Endonuclease/Exonuclease/phosphatase family) b1749(exonuclease III) BN373_18431(exodeoxyribonuclease III) t1181(exodeoxyribonuclease III) SL1344_1237(exodeoxyribonuclease III) Cluster1405 1 1 1 1 1 1 1 ROD_12991(CTP pyrophosphohydrolase) ENC_14560(ADP-ribose pyrophosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2121(CTP pyrophosphohydrolase,pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase,NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding,mutator mutT protein,NUDIX domain) b1759(CTP pyrophosphohydrolas; also hydrolyzes 2-hydroxy-dATP, 8-hydroxy-dGTP, CTP, dCTP and 5-methyl-dCTP) BN373_18341(CTP pyrophosphohydrolase) t1180(putative MutT-family protein) SL1344_1236(putative MutT-family protein) Cluster1406 1 1 1 1 1 1 1 ROD_12971(NADP-specific glutamate dehydrogenase) ENC_14570(glutamate dehydrogenase (NADP)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2119(NADP-specific glutamate dehydrogenase,glutamate dehydrogenase,Glutamate/Leucine/Phenylalanine/Valine dehydrogenase) b1761(glutamate dehydrogenase, NADP-specific) BN373_18331(NADP-specific glutamate dehydrogenase) t1178(NADP-specific glutamate dehydrogenase) SL1344_1234(NADP-specific glutamate dehydrogenase) Cluster1407 1 1 1 1 1 1 1 ROD_12941(Selenide,water dikinase) ENC_14670(selenophosphate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2117(Selenide, water dikinase,selenophosphate synthetase,Hydrogenase maturation factor,selenide, water dikinase,AIR synthase related protein, C-terminal domain) b1764(selenophosphate synthase) BN373_18301(selenide, water dikinase) t1176(selenophosphate synthase) SL1344_1232(Selenide,water dikinase) Cluster1408 1 1 1 1 1 1 1 ROD_12931(putative nitroreductase) ENC_14680(Nitroreductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2116(Putative NAD(P)H nitroreductase ydjA,putative oxidoreductase,5,6-dimethylbenzimidazole synthase,Nitroreductase family) b1765(predicted oxidoreductase) BN373_18271(nitroreductase family protein) t1175(putative nitroreductase) SL1344_1231(putative nitroreductase) Cluster1409 1 1 1 1 1 1 1 ROD_12921(protease IV) ENC_14690(signal peptide peptidase SppA, 67K type) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2115(Protease 4,protease 4,signal peptide peptidase SppA, 67K type,Peptidase family S49) b1766(protease IV (signal peptide peptidase)) BN373_18261(protease 4) t1174(protease IV) SL1344_1230(protease IV) Cluster1410 1 1 1 1 1 1 1 ROD_12911(L-Asparaginase I) ENC_14710(L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2113(L-asparaginase 1,cytoplasmic asparaginase I,L-asparaginase, type I,Asparaginase) b1767(cytoplasmic L-asparaginase I) BN373_18251(L-asparaginase 1) t1173(L-Asparaginase I) SL1344_1229(L-Asparaginase I) Cluster1411 1 1 1 1 1 1 1 ROD_12901(pyrazinamidase/nicotinamidase) ENC_14720(Amidases related to nicotinamidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2112(nicotinamidase/pyrazinamidase,pyrimidine utilization protein B,Isochorismatase family) b1768(nicotinamidase/pyrazinamidase) BN373_18241(pyrazinamidase/nicotinamidase) t1172(pyrazinamidase/nicotinamidase) SL1344_1228(pyrazinamidase/nicotinamidase) Cluster1412 1 1 1 1 1 1 1 ROD_12761(putative endonuclease) ENC_12430(HNH endonuclease.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3572(hypothetical protein,HNH endonuclease) b0410(conserved protein, HNH family) BN373_18221(HNH endonuclease domain protein) t2452(conserved hypothetical protein) SL1344_0406(conserved hypothetical protein) Cluster1413 1 1 1 1 1 1 1 ROD_12751(conserved hypothetical protein) ENC_14740(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2103(Protein of unknown function (DUF1315)) b1777(conserved protein) BN373_18211(conserved hypothetical protein) t1171(conserved hypothetical protein) SL1344_1227(conserved hypothetical protein) Cluster1414 1 1 1 1 1 1 1 ROD_12741(peptide methionine sulfoxide reductase) ENC_14750(methionine-R-sulfoxide reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2102(Peptide methionine sulfoxide reductase MsrB,methionine sulfoxide reductase B,methionine-R-sulfoxide reductase,SelR domain) b1778(methionine sulfoxide reductase B) BN373_18201(methionine-R-sulfoxide reductase) t1170(conserved hypothetical protein) SL1344_1226(conserved hypothetical protein) Cluster1415 1 1 1 1 1 1 1 ROD_12731(glyceraldehyde 3-phosphate dehydrogenase A) ENC_14760(glyceraldehyde-3-phosphate dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2101(Glyceraldehyde-3-phosphate dehydrogenase A,glyceraldehyde-3-phosphate dehydrogenase A,Transketolase,glyceraldehyde-3-phosphate dehydrogenase, type I,Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain) b1779(glyceraldehyde-3-phosphate dehydrogenase A) BN373_18191(gIyceraldehyde-3-phosphate dehydrogenase (phosphorylating)) t1169(glyceraldehyde 3-phosphate dehydrogenase A) SL1344_1225(glyceraldehyde 3-phosphate dehydrogenase A) Cluster1416 1 1 1 1 1 1 1 ROD_12691(putative serine protein kinase) ENC_14790(Putative Ser protein kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2097(PrkA family serine protein kinase,PrkA AAA domain) b1783(protein kinase, function unknown; autokinase) BN373_18151(serine protein kinase, PrkA family) t1164(conserved hypothetical protein) SL1344_1220(conserved hypothetical protein) Cluster1417 1 1 1 1 1 1 1 ROD_12681(conserved hypothetical protein) ENC_14800(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2096(hypothetical protein,Uncharacterized conserved protein,sporulation protein YhbH,Protein of unknown function (DUF444)) b1784(conserved protein) BN373_18141(conserved hypothetical protein) t1163(conserved hypothetical protein) SL1344_1219(conserved hypothetical protein) Cluster1418 1 1 1 1 1 1 1 ROD_12361(SOS mutagenesis and repair protein) ENC_35720(SOS response UmuD protein. Serine peptidase. MEROPS family S24) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2700(hypothetical protein,DNA polymerase V subunit UmuD,repressor LexA,Peptidase S24-like) b1183(DNA polymerase V, subunit D) BN373_18051(DNA polymerase V subunit UmuD) t0880(UmuD protein) SL1344_1926(DNA repair protein) Cluster1419 1 1 1 1 1 1 1 ROD_12661(conserved hypothetical protein) ENC_14810(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2093(Uncharacterized conserved protein,YbaK/EbsC protein,YbaK / prolyl-tRNA synthetases associated domain) b1787(conserved protein) BN373_18021(YbaK/prolyl-tRNA synthetase-associated domain protein) t1161(conserved hypothetical protein) SL1344_1217(conserved hypothetical protein) Cluster1420 1 1 1 1 1 1 1 ROD_12651(putative outer membrane protein) ENC_14850(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2092(Protein of unknown function (DUF441)) b1789(predicted inner membrane protein, UPF0756 family) BN373_18011(conserved hypothetical protein) t1160(putative membrane protein) SL1344_1216(putative membrane protein) Cluster1421 1 1 1 1 1 1 1 ROD_12611(conserved hypothetical protein) ENC_14900(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2089(Uncharacterized conserved protein,Protein of unknown function, DUF488) b1792(conserved protein) BN373_17961(conserved hypothetical protein) t1157(putative bacteriophage protein) SL1344_1213(predicted bacteriophage protein) Cluster1422 1 1 1 1 1 1 1 ROD_12591(putative exported protein) ENC_14920(Putative hemolysin) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2088(Putative hemolysin,Domain of unknown function (DUF333)) b1793(conserved outer membrane lipoprotein) BN373_17951(putative lipoprotein) t1155(conserved hypothetical protein) SL1344_1211(conserved hypothetical protein) Cluster1423 1 1 1 1 1 1 1 ROD_16741(putative outer membrane protein) ENC_39780(Protein of unknown function (DUF2534).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2434(Protein of unknown function (DUF2534)) b1332(predicted inner membrane protein, DUF2534 family) BN373_17911(conserved hypothetical protein) t1566(putative membrane protein) SL1344_1593(putative membrane protein) Cluster1424 1 2 0 0 2 1 1 ROD_03911(putative terminal oxidase subunit II) ENC_09290(cytochrome bd quinol oxidase subunit 2 apoprotein),ENC_31040(cytochrome bd quinol oxidase subunit 2 apoprotein) BN373_17791(putative cyanide-insensitive terminal oxidase CioB),BN373_25101(cyanide-insensitive terminal oxidase CioB) t2503(probable terminal oxidase subunit II) SL1344_0356(probable terminal oxidase subunit II) Cluster1425 1 2 0 0 2 1 1 ROD_03901(putative terminal oxidase subunit I) ENC_09300(cytochrome bd quinol oxidase subunit 1 apoprotein),ENC_31030(cytochrome bd quinol oxidase subunit 1 apoprotein) BN373_17781(putative cyanide-insensitive terminal oxidase CioA),BN373_25091(cyanide-insensitive terminal oxidase CioA) t2504(probable terminal oxidase subunit I) SL1344_0355(probable terminal oxidase subunit I) Cluster1426 1 1 1 1 1 1 1 ROD_04291(putative signal transduction protein) ENC_23760(diguanylate cyclase (GGDEF) domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3596(Probable diguanylate cyclase AdrA,diguanylate cyclase AdrA,Response regulator containing a CheY-like receiver domain and a GGDEF domain,diguanylate cyclase (GGDEF) domain,GGDEF domain) b0385(diguanylate cyclase for cellulose, biofilm, motility regulation) BN373_17661(MASE2 domain/diguanylate cyclase) t2479(adrA protein) SL1344_0380(adrA protein) Cluster1427 1 1 1 1 1 1 1 ROD_12261(isocitrate dehydrogenase [NADP]) ENC_14990(isocitrate dehydrogenase (NADP)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2780(Isocitrate dehydrogenase [NADP],isocitrate dehydrogenase,isocitrate dehydrogenase, NADP-dependent,Isocitrate/isopropylmalate dehydrogenase) b1136(e14 prophage; isocitrate dehydrogenase, specific for NADP+) BN373_17611(isocitrate dehydrogenase, NADP-dependent) t1682(isocitrate dehydrogenase) SL1344_1176(isocitrate dehydrogenase) Cluster1428 1 1 1 1 1 1 1 ROD_12241(putative NUDIX-family hydrolase) ENC_15010(ADP-ribose pyrophosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2782(Phosphatase nudJ,hypothetical protein,NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding,nucleoside triphosphatase YtkD,NUDIX domain) b1134(bifunctional thiamin pyrimidine pyrophosphate hydrolase/ thiamin pyrophosphate hydrolase) BN373_17591(hydrolase, NUDIX family) t1685(putative MutT-family protein) SL1344_1173(putative mutT family protein) Cluster1429 1 1 1 1 1 1 1 ROD_12231(tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase) ENC_15020(tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2783(tRNA-specific 2-thiouridylase mnmA,tRNA-specific 2-thiouridylase MnmA,Predicted ATPase of the PP-loop superfamily implicated in cell cycle control,tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase,tRN A methyl transferase) b1133(tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase) BN373_17581(tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase) t1686(tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase) SL1344_1172(Probable tRNA) Cluster1430 1 1 1 1 1 1 1 ROD_12211(adenylosuccinate lyase) ENC_15040(Adenylosuccinate lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2785(Adenylosuccinate lyase,adenylosuccinate lyase,Adenylosuccinate lyase,adenylosuccinate lyase,Lyase) b1131(adenylosuccinate lyase) BN373_17561(adenylosuccinate lyase) t1688(adenylosuccinate lyase) SL1344_1170(adenylosuccinate lyase) Cluster1431 1 1 1 1 1 1 1 ROD_12191(two-component response regulator) ENC_15070(Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2786(Transcriptional regulatory protein phoP,DNA-binding transcriptional regulator PhoP,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain) b1130(DNA-binding response regulator in two-component regulatory system with PhoQ) BN373_17531(transcriptional regulatory protein PhoP) t1689(transcriptional regulatory protein PhoP) SL1344_1169(transcriptional regulatory protein PhoP, regulator of virulence determinants) Cluster1432 1 1 1 1 1 1 1 ROD_12181(two-component sensor kinase) ENC_15080(Signal transduction histidine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2787(Sensor protein PhoQ,sensor protein PhoQ,Signal transduction histidine kinase regulating C4-dicarboxylate transport system,phosphate regulon sensor kinase PhoR,PhoQ Sensor) b1129(sensory histidine kinase in two-component regulatory system with PhoP) BN373_17521(sensor protein PhoQ) t1690(sensor protein PhoQ) SL1344_1168(sensor protein PhoQ, regulator of virulence determinants) Cluster1433 1 1 1 1 1 1 1 ROD_12171(conserved hypothetical protein) ENC_15090(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2788(hypothetical protein,Cupin superfamily protein) b1128(cupin superfamily protein) BN373_17511(cupin family protein) t1691(conserved hypothetical protein) SL1344_1167(conserved hypothetical protein) Cluster1434 1 1 1 1 1 1 1 ROD_12151(peptidase T) ENC_11050(peptidase T) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2789(Peptidase T,peptidase T,Metal-dependent amidase/aminoacylase/carboxypeptidase,peptidase T,Peptidase family M20/M25/M40) b1127(peptidase T) BN373_17501(peptidase T) t1693(aminotripeptidase) SL1344_1164(Peptidase T) Cluster1435 1 1 1 1 1 1 1 ROD_12131(spermidine/putrescine ABC transporter, permease protein) ENC_15140(ABC-type spermidine/putrescine transport system, permease component I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2791(Spermidine/putrescine transport system permease protein PotB,spermidine/putrescine ABC transporter membrane protein,ABC-type spermidine/putrescine transport systems, ATPase components,NifC-like ABC-type porter,Binding-protein-dependent transport system inner membrane component) b1125(polyamine transporter subunit) BN373_17481(spermidine/putrescine ABC transporter, permease protein PotB) t1695(spermidine/putrescine transport system permease protein PotB) SL1344_1162(spermidine/putrescine transport system permease protein PotB) Cluster1436 1 1 1 1 1 1 1 ROD_12041(spermidine/putrescine ABC transporter, permease protein) ENC_15150(ABC-type spermidine/putrescine transport system, permease component II) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2792(Inner membrane ABC transporter permease protein ydcV,spermidine/putrescine ABC transporter membrane protein,ABC-type uncharacterized transport system, permease component,2-aminoethylphosphonate ABC transport system, membrane component PhnV,Binding-protein-dependent transport system inner membrane component) b1124(polyamine transporter subunit) BN373_17471(spermidine/putrescine ABC transporter, permease protein PotC) t1697(spermidine/putrescine transport system permease protein PotC) SL1344_1160(spermidine/putrescine transport system permease protein PotC) Cluster1437 1 1 1 1 1 1 1 ROD_12031(spermidine/putrescine ABC transporter, substrate-binding protein) ENC_15160(Spermidine/putrescine-binding periplasmic protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2793(Spermidine/putrescine-binding periplasmic protein precursor,spermidine/putrescine ABC transporter periplasmic substrate-binding protein,ABC-type uncharacterized transport system, periplasmic component,putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein,Bacterial extracellular solute-binding protein) b1123(polyamine transporter subunit) BN373_17461(spermidine/putrescine ABC transporter, periplasmic spermidine/putrescine-binding protein) t1698(spermidine/putrescine-binding periplasmic protein precursor) SL1344_1159(spermidine/putrescine-binding periplasmic protein precursor) Cluster1438 1 1 1 1 1 1 1 ROD_11871(NAD-dependent deacetylase (regulatory protein Sir homolog)) ENC_15170(NAD-dependent protein deacetylases, SIR2 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2796(NAD-dependent deacetylase,NAD-dependent deacetylase,Sir2 family) b1120(deacetylase of acs and cheY, regulates chemotaxis) BN373_17311(NAD-dependent deacetylase) t1699(putative regulatory protein) SL1344_1158(NAD-dependent deacetylase) Cluster1439 1 1 1 1 1 1 1 ROD_11861(N-acetyl-D-glucosamine kinase) ENC_15180(Transcriptional regulator/sugar kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2797(N-acetyl-D-glucosamine kinase,N-acetyl-D-glucosamine kinase,Predicted phosphosugar isomerases,ROK family protein (putative glucokinase),ROK family) b1119(N-acetyl-D-glucosamine kinase) BN373_17301(N-acetylglucosamine kinase) t1700(putative ROK-family protein) SL1344_1157(putative ROK-family protein) Cluster1440 1 1 1 1 1 1 1 ROD_11851(lipoprotein-releasing system transmembrane protein) ENC_15200(ABC-type transport system, involved in lipoprotein release, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2798(Lipoprotein-releasing system transmembrane protein lolE,outer membrane-specific lipoprotein transporter subunit LolE,lipoprotein releasing system, transmembrane protein LolE,FtsX-like permease family) b1118(lipoprotein-releasing system transmembrane protein) BN373_17291(lipoprotein releasing system, transmembrane protein LolE) t1701(ABC transporter integral membrane subunit) SL1344_1156(ABC transporter integral membrane subunit) Cluster1441 1 1 1 1 1 1 1 ROD_11841(lipoprotein-releasing system ATP-binding protein) ENC_15210(lipoprotein releasing system, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2799(Lipoprotein-releasing system ATP-binding protein LolD,lipoprotein transporter ATP-binding subunit,Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component,lipoprotein releasing system, ATP-binding protein,ABC transporter) b1117(outer membrane-specific lipoprotein transporter subunit) BN373_17281(lipoprotein releasing system, ATP-binding protein LolD) t1702(ABC transporter ATP-binding subunit) SL1344_1155(ABC transporter ATP-binding subunit) Cluster1442 1 1 1 1 1 1 1 ROD_11831(lipoprotein-releasing system transmembrane protein) ENC_15220(lipoprotein releasing system, transmembrane protein, LolC/E family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2800(Lipoprotein-releasing system transmembrane protein lolC,outer membrane-specific lipoprotein transporter subunit LolC,lipoprotein releasing system, transmembrane protein, LolC/E family,FtsX-like permease family) b1116(lipoprotein-releasing system transmembrane protein) BN373_17271(lipoprotein-releasing system transmembrane protein LolC) t1703(ABC transporter integral membrane subunit) SL1344_1154(ABC transporter integral membrane subunit) Cluster1443 1 1 1 1 1 1 1 ROD_11811(transcription-repair coupling factor) ENC_15240(transcription-repair coupling factor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2802(Transcription-repair-coupling factor,transcription-repair coupling factor,Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein),transcription-repair coupling factor,TRCF domain) b1114(transcription-repair coupling factor) BN373_17261(transcription-repair coupling factor) t1704(transcription-repair coupling factor) SL1344_1153(transcription-repair coupling factor (TrcF)) Cluster1444 1 1 1 1 1 1 1 ROD_11751(TetR-family transcriptional regulator) ENC_15270(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2805(DNA-binding transcriptional repressor AcrR,mycofactocin system transcriptional regulator,Bacterial regulatory proteins, tetR family) b1111(repressor for bhsA(ycfR)) BN373_17231(transcriptional regulator, TetR family) t1707(putative TetR-family regulatory protein) SL1344_1150(putative TetR-family regulatory protein) Cluster1445 1 1 1 1 1 1 1 ROD_11731(putative exported protein) ENC_15280(Predicted outer membrane lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2806(hypothetical protein,Uncharacterized protein conserved in bacteria,Glycine zipper 2TM domain) b1110(predicted protein) BN373_17211(surface antigen domain protein) t1708(putative secreted protein) SL1344_1149(putative secreted protein) Cluster1446 1 1 1 1 1 1 1 ROD_11721(NADH dehydrogenase) ENC_09900(NADH dehydrogenase, FAD-containing subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2807(NADH dehydrogenase,NADH:flavorubredoxin oxidoreductase,Uncharacterized conserved protein,pyridine nucleotide-disulfide oxidoreductase family protein,Pyridine nucleotide-disulphide oxidoreductase) b1109(respiratory NADH dehydrogenase 2/cupric reductase) BN373_17201(NADH dehydrogenase) t1709(NADH dehydrogenase) SL1344_1148(NADH dehydrogenase) Cluster1447 1 1 1 1 1 1 1 ROD_11701(conserved hypothetical protein) ENC_15300(Predicted esterase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2808(hypothetical protein,Predicted esterase,Uncharacterised protein family (UPF0227)) b1108(conserved protein) BN373_17191(conserved hypothetical protein) t1710(conserved hypothetical protein) SL1344_1147(conserved hypothetical protein) Cluster1448 1 1 1 1 1 1 1 ROD_11691(Beta-hexosaminidase) ENC_15310(beta-N-acetylhexosaminidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2809(Beta-hexosaminidase,beta-hexosaminidase,Glycosyl hydrolase family 3 N terminal domain) b1107(beta N-acetyl-glucosaminidase) BN373_17181(beta-N-acetylhexosaminidase) t1711(putative glycosyl hydrolase) SL1344_1146(Beta-hexosaminidase) Cluster1449 1 1 1 1 1 1 1 ROD_11661(putative lipoprotein) ENC_15340(Predicted periplasmic lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2812(Predicted periplasmic lipoprotein,Protein of unknown function (DUF1425)) b1104(predicted protein) BN373_17151(putative lipoprotein) t1714(putative lipoprotein) SL1344_1143(putative lipoprotein) Cluster1450 1 1 1 1 1 1 1 ROD_11651(putative nucleotide-binding protein) ENC_15350(Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2813(HIT-like protein hinT,purine nucleoside phosphoramidase,HIT domain) b1103(purine nucleoside phosphoramidase, dadA activator protein) BN373_17141(purine nucleoside phosphoramidase) t1715(putative protein kinase C inhibitor) SL1344_1142(putative protein kinase C inhibitor) Cluster1451 1 1 1 1 1 1 1 ROD_11631(glucose-specific PTS system IIBC component) ENC_15370(PTS system D-glucose-specific IIB component, Glc family (TC 4.A.1.1.1)/PTS system D-glucose-specific IIC component, Glc family (TC 4.A.1.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2815(EIICB-Glc,PTS system glucose-specific transporter subunits IIBC,PTS system, glucose-specific IIBC component,Phosphotransferase system, EIIC) b1101(fused glucose-specific PTS enzymes: IIB component/IIC component) BN373_17131(PTS system, glucose-specific IIBC component) t1717(glucose-specific IIBC component of PTS system) SL1344_1140(PTS system, glucose-specific IIBC component) Cluster1452 1 1 1 1 1 1 1 ROD_11621(putative deoxyribonuclease) ENC_15380(hydrolase, TatD family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2816(Uncharacterized deoxyribonuclease YcfH,putative DNAse,Mg-dependent DNase,hydrolase, TatD family,TatD related DNase) b1100(predicted DNAse) BN373_17121(hydrolase, TatD family) t1718(conserved hypothetical protein) SL1344_1139(conserved hypothetical protein) Cluster1453 1 1 1 1 1 1 1 ROD_11611(DNA polymerase III, delta subunit) ENC_15390(DNA polymerase III, delta prime subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2817(DNA polymerase III subunit delta',DNA polymerase III subunit delta',DNA polymerase III, delta' subunit,DNA polymerase III, delta subunit, C terminal) b1099(DNA polymerase III, delta prime subunit) BN373_17111(DNA polymerase III, delta' subunit) t1719(DNA polymerase III, delta' subunit) SL1344_1138(DNA polymerase III, delta' subunit) Cluster1454 1 1 1 1 1 1 1 ROD_11601(Thymidylate kinase) ENC_15400(thymidylate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2818(Thymidylate kinase,thymidylate kinase,thymidylate kinase,Thymidylate kinase) b1098(thymidylate kinase) BN373_17101(thymidylate kinase) t1720(thymidylate kinase) SL1344_1137(Thymidylate kinase) Cluster1455 1 1 1 1 1 1 1 ROD_11581(4-amino-4-deoxychorismate lyase) ENC_15430(aminodeoxychorismate lyase apoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2820(Aminodeoxychorismate lyase,4-amino-4-deoxychorismate lyase,Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase,aminodeoxychorismate lyase,Aminotransferase class IV) b1096(4-amino-4-deoxychorismate lyase component of para-aminobenzoate synthase multienzyme complex) BN373_17081(aminodeoxychorismate lyase) t1722(4-amino-4-deoxychorismate lyase) SL1344_1135(4-amino-4-deoxychorismate lyase) Cluster1456 1 1 1 1 1 1 1 ROD_11571(3-oxoacyl-[acyl-carrier-protein] synthase 2) ENC_15440(3-oxoacyl-[acyl-carrier-protein] synthase II) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2821(3-oxoacyl-[acyl-carrier-protein] synthase 2,3-oxoacyl-(acyl carrier protein) synthase II,Enoyl reductase domain of yeast-type FAS1,beta-ketoacyl-acyl-carrier-protein synthase II,Beta-ketoacyl synthase, N-terminal domain) b1095(3-oxoacyl-[acyl-carrier-protein] synthase II) BN373_17071(3-oxoacyl-[acyl-carrier-protein] synthase II) t1723(3-oxoacyl-[acyl-carrier-protein] synthase II) SL1344_1134(3-oxoacyl-[acyl-carrier-protein] synthase II) Cluster1457 1 1 1 1 1 1 1 ROD_11561(acyl carrier protein) ENC_15450(acyl carrier protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2822(Fatty acid synthase acyl carrier protein,acyl carrier protein,Acyl carrier protein,acyl carrier protein,Phosphopantetheine attachment site) b1094(acyl carrier protein (ACP)) BN373_17061(acyl carrier protein) t1724(acyl carrier protein) SL1344_1133(acyl carrier protein) Cluster1458 1 1 1 1 1 1 1 ROD_11551(3-oxoacyl-[acyl-carrier protein] reductase) ENC_15460(3-oxoacyl-[acyl-carrier-protein] reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2823(3-oxoacyl-[acyl-carrier-protein] reductase FabG,3-ketoacyl-(acyl-carrier-protein) reductase,Uncharacterized conserved protein,3-oxoacyl-[acyl-carrier-protein] reductase,short chain dehydrogenase) b1093(3-oxoacyl-[acyl-carrier-protein] reductase) BN373_17051(3-oxoacyl-[acyl-carrier-protein] reductase) t1725(3-oxoacyl-[acyl-carrier protein] reductase) SL1344_1132(3-oxoacyl-[acyl-carrier protein] reductase) Cluster1459 1 1 1 1 1 1 1 ROD_11541(malonyl CoA-acyl carrier protein transacylase) ENC_15470([Acyl-carrier-protein] S-malonyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2824(Malonyl CoA-acyl carrier protein transacylase,(acyl-carrier-protein) S-malonyltransferase,malonyl CoA-acyl carrier protein transacylase,Acyl transferase domain) b1092(malonyl-CoA-[acyl-carrier-protein] transacylase) BN373_17041(malonyl CoA-acyl carrier protein transacylase) t1726(malonyl CoA-acyl carrier protein transacylase) SL1344_1131(malonyl CoA-acyl carrier protein transacylase) Cluster1460 1 1 1 1 1 1 1 ROD_11521(fatty acid/phospholipid synthesis protein) ENC_15500(phosphate:acyl-[acyl carrier protein] acyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2826(Phosphate acyltransferase,putative phosphate acyltransferase,Fatty acid/phospholipid biosynthesis enzyme,fatty acid/phospholipid synthesis protein PlsX,Fatty acid synthesis protein) b1090(probable phosphate acyltransferase) BN373_17021(fatty acid/phospholipid synthesis protein PlsX) t1728(fatty acid/phospholipid synthesis protein PlsX) SL1344_1129(Fatty acid/phospholipid synthesis protein plsX) Cluster1461 1 1 1 1 1 1 1 ROD_11511(50S ribosomal protein L32) ENC_15510(LSU ribosomal protein L32P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2827(50S ribosomal protein L32,50S ribosomal protein L32,ribosomal protein L32,Ribosomal L32p protein family) b1089(50S ribosomal subunit protein L32) BN373_17011(ribosomal protein L32) t1729(50S ribosomal protein L32) SL1344_1128(50S ribosomal protein L32. Chloroplast 50S ribosomal protein L32) Cluster1462 1 1 1 1 1 1 1 ROD_11501(conserved hypothetical protein) ENC_15520(Predicted metal-binding, possibly nucleic acid-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2828(hypothetical protein,Uncharacterized ACR, COG1399) b1088(conserved protein, DUF177 family) BN373_17001(conserved hypothetical protein) t1730(conserved hypothetical protein) SL1344_1127(conserved hypothetical protein) Cluster1463 1 1 1 1 1 1 1 ROD_11291(conserved hypothetical protein) ENC_15770(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2849(G20.3,hypothetical protein,Uncharacterized protein conserved in bacteria,Protein of unknown function, DUF480) b1067(conserved protein, UPF0502 family) BN373_16921(conserved hypothetical protein) t1752(conserved hypothetical protein) SL1344_1105(conserved hypothetical protein) Cluster1464 1 1 1 1 1 1 1 ROD_11281(ribosomal-protein-alanine acetyltransferase) ENC_15780([SSU ribosomal protein S5P]-alanine acetyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2850(Putative ribosomal N-acetyltransferase YdaF,ribosomal-protein-S5-alanine N-acetyltransferase,pseudaminic acid biosynthesis N-acetyl transferase,Acetyltransferase (GNAT) family) b1066(ribosomal-protein-S5-alanine N-acetyltransferase) BN373_16911(ribosomal-protein-alanine acetyltransferase) t1753(ribosomal-protein-alanine acetyltransferase) SL1344_1104(ribosomal-protein-alanine acetyltransferase) Cluster1465 1 1 1 1 1 1 1 pseudoROD_11261(multidrug resistance protein MdtH (pseudogene)) ENC_15790(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2851(Multidrug resistance protein MdtH,multidrug resistance protein MdtH,Arabinose efflux permease,multidrug resistance protein,Major Facilitator Superfamily) b1065(multidrug resistance efflux transporter conferring overexpression resistance to norfloxacin and enoxacin) BN373_16901(multidrug resistance protein MdtH) t1754(putative membrane transporter) SL1344_1103(putative membrane transporter) Cluster1466 1 1 1 1 1 1 1 ROD_11231(putative lipoprotein) ENC_15800(Protein of unknown function (DUF1439).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2853(Uncharacterized lipoprotein yceB precursor,lipoprotein,Protein of unknown function (DUF1439)) b1063(lipoprotein, DUF1439 family) BN373_16891(putative lipoprotein) t1756(conserved hypothetical protein) SL1344_1101(conserved hypothetical protein) Cluster1467 1 1 1 1 1 1 1 ROD_11221(dihydroorotase) ENC_15810(dihydroorotase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2854(Dihydroorotase,dihydroorotase,Dihydroorotase,dihy droorotase, homodimeric type,Amidohydrolase family) b1062(dihydro-orotase) BN373_16881(dihydroorotase, homodimeric type) t1757(dihydroorotase) SL1344_1100(Dihydroorotase) Cluster1468 1 1 1 1 1 1 1 ROD_11211(damage-inducible protein) ENC_15820(DinI-like family.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2855(DNA-damage-inducible protein I,DNA damage-inducible protein I,DinI-like family) b1061(DNA damage-inducible protein I) BN373_16871(DNA-damage-inducible protein I) t1758(damage-inducible protein) SL1344_1099(damage-inducible protein) Cluster1469 1 1 1 1 1 1 1 ROD_11191(biofilm regulator) ENC_15830(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2856(biofilm formation regulatory protein BssS) b1060(biofilm regulator) BN373_16861(conserved hypothetical protein) t1759(conserved hypothetical protein) SL1344_1098(conserved hypothetical protein) Cluster1470 1 1 1 1 1 1 1 ROD_11181(N-methyl-L-tryptophan oxidase) ENC_15840(Glycine/D-amino acid oxidases (deaminating)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2857(N-methyl-L-tryptophan oxidase,N-methyltryptophan oxidase,Uncharacterized conserved protein,sarcosine oxidase, monomeric form,FAD dependent oxidoreductase) b1059(N-methyltryptophan oxidase, FAD-binding) BN373_16851(N-methyl-L-tryptophan oxidase) t1760(putative sarcosine oxidase) SL1344_1097(N-methyl-L-tryptophan oxidase) Cluster1471 1 1 1 1 1 1 1 ROD_11141(rhodanase-like protein) ENC_15860(Predicted sulfurtransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2861(Probable adenylyltransferase/sulfurtransferase MoeZ,putative rhodanese-related sulfurtransferase,Uncharacterized conserved protein,Rhodanese-like domain) b1055(predicted rhodanese-related sulfurtransferase) BN373_16831(rhodanese domain protein) t1764(conserved hypothetical protein) SL1344_1093(conserved hypothetical protein) Cluster1472 1 1 1 1 1 1 1 ROD_11121(multidrug resistance protein) ENC_15880(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2863(Metal-tetracycline/H(+) antiporter,drug efflux system protein MdtG,Arabinose efflux permease,multidrug resistance protein,Major Facilitator Superfamily) b1053(predicted drug efflux system) BN373_16811(multidrug resistance protein MdtG) t1766(putative membrane transport protein) SL1344_1091(putative membrane transport protein) Cluster1473 1 1 1 1 1 1 1 ROD_11111(acidic protein) ENC_15890(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2864(secY/secA suppressor protein) b1051(multicopy suppressor of secY and secA) BN373_16801(acidic protein MsyB) t1767(acidic protein MsyB) SL1344_1090(acidic protein MsyB; multicopy suppressor of SecY) Cluster1474 1 1 1 1 1 1 1 ROD_11101(putative lipoprotein) ENC_15900(Predicted periplasmic lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2865(lipoprotein,Predicted periplasmic lipoprotein,Protein of unknown function (DUF1375)) b1050(lipoprotein, DUF1375 family) BN373_16791(putative lipoprotein) t1768(putative lipoprotein) SL1344_1089(putative lipoprotein) Cluster1475 1 1 1 1 1 1 1 ROD_11091(glucans biosynthesis glucosyltransferase) ENC_15910(Membrane glycosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2866(Glucans biosynthesis glucosyltransferase H,glucosyltransferase MdoH,Glycosyl transferase family 2) b1049(membrane glycosyltransferase) BN373_16781(glucans biosynthesis glucosyltransferase H) t1769(periplasmic glucans biosynthesis protein MdoH) SL1344_1088(Glucans biosynthesis glucosyltransferase H) Cluster1476 1 1 1 1 1 1 1 ROD_11081(glucans biosynthesis protein G) ENC_15920(Periplasmic glucans biosynthesis protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2867(Glucans biosynthesis protein G precursor,glucan biosynthesis protein G,Periplasmic glucans biosynthesis protein,Periplasmic glucan biosynthesis protein, MdoG) b1048(osmoregulated periplasmic glucan (OPG) biosynthesis periplasmic protein) BN373_16771(glucans biosynthesis protein G) t1770(periplasmic glucans biosynthesis protein MdoG precursor) SL1344_1087(Glucans biosynthesis protein G precursor) Cluster1477 1 1 1 1 1 1 1 ROD_11061(glucans biosynthesis acyltransferase) ENC_15940(Acyltransferase family.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2868(Glucans biosynthesis protein C,glucans biosynthesis protein,Uncharacterized protein conserved in bacteria,Acyltransferase family) b1047(membrane protein required for succinylation of osmoregulated periplasmic glucans (OPGs)) BN373_16761(putative glucans biosynthesis protein C) t1771(glucans biosynthesis protein) SL1344_1086(Glucans biosynthesis protein C) Cluster1478 1 1 1 1 1 1 1 ROD_11041(putative DNA and/or RNA unwinding protein) ENC_15950(Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2870(O-acetyl-ADP-ribose deacetylase,RNase III inhibitor,Macro domain) b1045(O-acetyl-ADP-ribose deacetylase; RNase III inhibitor during cold shock) BN373_16741(Appr-1-p processing enzyme domain protein) t1773(conserved hypothetical protein) SL1344_1084(Hypothetical UPF0189 protein) Cluster1479 1 1 1 1 1 1 1 ROD_10931(putative chaperone) ENC_16020(Uncharacterized component of anaerobic dehydrogenases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2880(Chaperone protein YcdY,twin-argninine leader-binding protein DmsD,Uncharacterized component of anaerobic dehydrogenases,Nitrate reductase delta subunit) b1035(conserved protein, REMP family) BN373_16721(chaperone, TorD family) t1783(conserved hypothetical protein) SL1344_1074(conserved hypothetical protein) Cluster1480 1 1 1 1 1 1 1 ROD_10921(putative phosphoesterase) ENC_16030(Histidinol phosphatase and related hydrolases of the PHP family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2881(Probable phosphatase YcdX,putative hydrolase,Histidinol phosphatase and related hydrolases of the PHP family,histidinol phosphate phosphatase, HisJ family,PHP domain) b1034(predicted zinc-binding hydrolase) BN373_16711(PHP domain protein) t1784(conserved hypothetical protein) SL1344_1073(conserved hypothetical protein) Cluster1481 1 1 1 1 1 1 1 ROD_10911(putative 2-hydroxyacid dehydrogenase) ENC_16040(Phosphoglycerate dehydrogenase and related dehydrogenases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2882(Glyoxylate/hydroxypyruvate reductase A,bifunctional glyoxylate/hydroxypyruvate reductase A,Phosphoserine aminotransferase,phosphoglycerate dehydrogenase,D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain) b1033(glyoxylate/hydroxypyruvate reductase A) BN373_16701(putative dehydrogenase) t1785(putative 2-hydroxyacid dehydrogenase in phoh-csgg intergenic region) SL1344_1072(putative 2-hydroxyacid dehydrogenase in phoh-csgg intergenic region) Cluster1482 1 1 1 1 1 1 1 ROD_09611(putative isochorismatase) ENC_31170(Amidases related to nicotinamidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3046(hypothetical protein,nicotinamidase/pyrazinamidase,Isochorismatase family) b0897(predicted hydrolase, isochorismatase family) BN373_16651(isochorismatase hydrolase family protein) t3757(conserved hypothetical protein) SL1344_3726(conserved hypothetical protein) Cluster1483 1 1 1 1 1 1 1 ROD_10681(bifunctional protein PutA) ENC_16200(L-proline dehydrogenase /delta-1-pyrroline-5-carboxylate dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2895(Bifunctional protein putA,trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase,Delta 1-pyrroline-5-carboxylate dehydrogenase,delta-1-pyrroline-5-carboxylate dehydrogenase,Proline dehydrogenase) b1014(fused DNA-binding transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase) BN373_16561(bifunctional protein PutA) t1797(proline dehydrogenase) SL1344_1062(proline dehydrogenase (proline oxidase)) Cluster1484 1 1 1 1 1 1 1 ROD_10661(rut operon repressor (TetR-family transcriptional regulator)) ENC_16220(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2896(Rut operon repressor,HTH-type transcriptional regulator RutR,pyrimidine utilization regulatory protein R,YcdC-like protein, C-terminal region) b1013(DNA-binding transcriptional repressor for rut operon) BN373_16541(transcriptional regulator RutR) t1799(putative transcriptional regulator) SL1344_1060(putative transcriptional regulator) Cluster1485 1 1 1 1 1 1 1 ROD_10641(flavoprotein (Trp repressor-binding protein)) ENC_16400(NAD(P)H:quinone oxidoreductase, type IV) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2905(Trp repressor-binding protein,NAD(P)H:quinone oxidoreductase,Flavodoxin,NAD(P)H:quinone oxidoreductase, type IV,NADPH-dependent FMN reductase) b1004(NAD(P)H:quinone oxidoreductase) BN373_16421(NAD(P)H:quinone oxidoreductase, type IV) t1801(trp repressor binding protein) SL1344_1058(trp repressor binding protein) Cluster1486 1 1 1 1 1 1 1 ROD_10631(conserved hypothetical protein) ENC_16410(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2906(hypothetical protein,hypothetical protein) b1003(predicted protein) BN373_16411(conserved hypothetical protein) t1802(conserved hypothetical protein) SL1344_1057(conserved hypothetical protein) Cluster1487 1 0 1 1 2 1 1 ROD_17651(oligopeptide ABC transporter, substrate-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2595(Periplasmic oligopeptide-binding protein precursor,oligopeptide ABC transporter substrate-binding protein OppA,ABC-type oligopeptide transport system, periplasmic component,nickel ABC transporter, nickel/metallophore periplasmic binding protein,Bacterial extracellular solute-binding proteins, family 5 Middle) b1243(oligopeptide transporter subunit) BN373_16211(periplasmic oligopeptide-binding protein),BN373_27931(oligopeptide ABC transporter, periplasmic oligopeptide-binding protein) t1658(periplasmic oligopeptide-binding protein precursor) SL1344_1677(periplasmic oligopeptide-binding protein precursor (OppA)) Cluster1488 1 1 1 1 1 1 1 ROD_10321(putative outer membrane protein) ENC_16570(Integral membrane protein, interacts with FtsH) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2930(Modulator of FtsH protease YccA,HflBKC-binding inner membrane protein,Inhibitor of apoptosis-promoting Bax1) b0970(HflBKC-binding inner membrane protein, UPF0005 family) BN373_16201(putative membrane protein) t1834(putative membrane protein) SL1344_1025(putative membrane protein) Cluster1489 1 1 1 1 1 1 1 ROD_10311(sulfurtransferase (tRNA 2-thiouridine synthesizing protein E)) ENC_16580(sulfur relay protein, TusE/DsrC/DsvC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2931(Sulfurtransferase TusE,sulfur transfer protein TusE,sulfur relay protein, TusE/DsrC/DsvC family,DsrC like protein) b0969(sulfurtransferase required for 2-thiolation step of mnm(5)-s(2)U34-tRNA synthesis) BN373_16191(sulfurtransferase TusE) t1835(hypothetical protein in helD-serT intergenic region) SL1344_1024(hypothetical protein in helD-serT intergenic region) Cluster1490 1 1 1 1 1 1 1 ROD_10301(putative acylphosphatase) ENC_16590(Acylphosphatases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2932(Acylphosphatase,acylphosphatase,Hydrogenase maturation factor,carbamoyltransferase HypF,Acylphosphatase) b0968(weak acylphosphatase) BN373_16181(acylphosphatase) t1836(putative acylphosphatase) SL1344_1023(putative acylphosphatase) Cluster1491 1 1 1 1 1 1 1 ROD_10291(conserved hypothetical protein) ENC_16600(SAM-dependent methyltransferase /23S rRNA m(5)C-1962 methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2933(Ribosomal RNA large subunit methyltransferase I,23S rRNA m(5)C1962 methyltransferase,Uncharacterized conserved protein,RNA methyltransferase, RsmD family,S-adenosylmethionine-dependent methyltransferase) b0967(23S rRNA m(5)C1962 methyltransferase, SAM-dependent) BN373_16081(conserved hypothetical protein) t1840(conserved hypothetical protein) SL1344_1020(conserved hypothetical protein) Cluster1492 1 1 1 1 1 1 1 ROD_10281(conserved hypothetical protein) ENC_16610(hemimethylated DNA binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2934(Heat shock protein hspQ,heat shock protein HspQ,hemimethylated DNA binding domain,Hemimethylated DNA-binding protein YccV like) b0966(heat shock protein involved in degradation of mutant DnaA; hemimethylated oriC DNA-binding protein) BN373_16071(hemimethylated DNA-binding protein) t1841(conserved hypothetical protein) SL1344_1019(conserved hypothetical protein) Cluster1493 1 1 1 1 1 1 1 ROD_10271(putative CoA-binding protein) ENC_16620(Predicted CoA-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2935(hypothetical protein,acetyl coenzyme A synthetase (ADP forming), alpha domain) b0965(predicted CoA-binding protein with NAD(P)-binding Rossmann-fold domain) BN373_16061(putative CoA-binding protein) t1842(conserved hypothetical protein) SL1344_1018(conserved hypothetical protein) Cluster1494 1 1 1 1 1 1 1 ROD_10251(methylglyoxal synthase) ENC_16650(methylglyoxal synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2937(Methylglyoxal synthase,methylglyoxal synthase,Methylglyoxal synthase,methylglyoxal synthase,MGS-like domain) b0963(methylglyoxal synthase) BN373_16051(methylglyoxal synthase) t1844(methylglyoxal synthase) SL1344_1016(methylglyoxal synthase) Cluster1495 1 1 1 1 1 1 1 ROD_10241(helicase IV) ENC_16660(Superfamily I DNA and RNA helicases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2938(Helicase IV,DNA helicase IV,ATP-dependent DNA helicase PcrA,DNA helicase IV / RNA helicase N terminal) b0962(DNA helicase IV) BN373_16041(helicase IV) t1845(helicase IV) SL1344_1015(helicase IV (75 kD helicase)) Cluster1496 1 1 1 1 1 1 1 ROD_10231(putative membrane protein) ENC_16670(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2939(Inner membrane protein yccF,hypothetical protein,Predicted membrane protein,Domain of unknown function (DUF307)) b0961(inner membrane protein, DUF307 family) BN373_16031(conserved hypothetical protein) t1846(putative membrane protein) SL1344_1014(putative membrane protein) Cluster1497 1 1 1 1 1 1 1 ROD_10221(putative membrane protein) ENC_16680(hypothetical membrane protein, TIGR01666) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2940(Inner membrane protein yccS,TIGR01666 family membrane protein,FUSC-like inner membrane protein yccS) b0960(inner membrane protein) BN373_16021(integral membrane protein, YccS/YhfK family) t1847(putative membrane protein) SL1344_1013(putative membrane protein) Cluster1498 1 1 1 1 1 1 1 ROD_10211(conserved hypothetical protein) ENC_16690(Regulator of competence-specific genes) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2941(hypothetical protein,Regulator of competence-specific genes,TfoX N-terminal domain) b0959(required for expression of CRP-S-dependent promoters) BN373_16011(conserved hypothetical protein) t1848(conserved hypothetical protein) SL1344_1012(conserved hypothetical protein) Cluster1499 1 1 1 1 1 1 1 ROD_10201(cell division inhibitor) ENC_16700(SOS cell division inhibitor SulA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2942(Cell division inhibitor SulA,SOS cell division inhibitor,SOS-response cell division inhibitor, blocks FtsZ ring formation,cell division inhibitor SulA,Cell division inhibitor SulA) b0958(SOS cell division inhibitor) BN373_15991(cell division inhibitor SulA) t1849(cell division inhibitor) SL1344_1011(cell division inhibitor) Cluster1500 1 1 1 1 1 1 1 ROD_10191(outer membrane protein A) ENC_31140(Opacity protein and related surface antigens) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2943(Outer membrane protein II*,outer membrane protein A,Outer membrane protein and related peptidoglycan-associated (lipo)proteins,peptidoglycan-associated lipoprotein,OmpA-like transmembrane domain) b0957(outer membrane protein A (3a;II*;G;d)) BN373_15981(outer membrane protein A) t1850(outer membrane protein A) SL1344_1010(outer membrane protein A) Cluster1501 1 1 1 1 1 1 1 ROD_10181(conserved hypothetical protein) ENC_16720(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2944(Macrodomain Ter protein,Ter macrodomain organizer matS-binding protein,Uncharacterized protein conserved in bacteria,Organiser of macrodomain of Terminus of chromosome) b0956(Ter macrodomain organizer matS-binding protein) BN373_15971(conserved hypothetical protein) t1851(conserved hypothetical protein) SL1344_1009(conserved hypothetical protein) Cluster1502 1 1 1 1 1 1 1 ROD_10161(conserved hypothetical protein) ENC_16740(Predicted ATP-dependent protease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2945(ATP-dependent protease Lon,Archaeal serine proteases,putative ATP-dependent protease,Lon protease (S16) C-terminal proteolytic domain) b0955(predicted peptidase) BN373_15961(peptidase, S16 (lon protease) family) t1852(conserved hypothetical protein) SL1344_1008(conserved hypothetical protein) Cluster1503 1 1 1 1 1 1 1 ROD_10141(putative lipoprotein) ENC_16770(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2948(ABC-type uncharacterized transport system, auxiliary component,Protein of unknown function (DUF330)) b0952(conserved protein) BN373_15931(putative lipoprotein) t1855(putative lipoprotein) SL1344_1005(putative lipoprotein) Cluster1504 1 1 1 1 1 1 1 ROD_10131(paraquat-inducible protein B) ENC_16780(Paraquat-inducible protein B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2949(hypothetical protein,paraquat-inducible protein B,virulence factor Mce family protein,mce related protein) b0951(paraquat-inducible protein B) BN373_15921(mce-related protein) t1856(putative secreted protein) SL1344_1004(putative secreted protein) Cluster1505 1 1 1 1 1 1 1 ROD_10121(paraquat-inducible protein A) ENC_16790(integral membrane protein, PqiA family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2950(Inner membrane protein yebS,paraquat-inducible membrane protein A,Uncharacterized paraquat-inducible protein A,integral membrane protein, PqiA family,Paraquat-inducible protein A) b0950(paraquat-inducible membrane protein A) BN373_15911(integral membrane protein, PqiA family) t1857(putative inner membrane protein) SL1344_1003(putative inner membrane protein) Cluster1506 1 1 1 1 1 1 1 ROD_10111(ABC transporter ATP-binding protein) ENC_16800(ATPase components of ABC transporters with duplicated ATPase domains) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2951(Uncharacterized ABC transporter ATP-binding protein Rv2477c/MT2552,ABC transporter ATPase component,ATP-dependent transcriptional regulator,ATP-binding cassette protein, ChvD family,ABC transporter) b0949(fused predicted transporter subunits of ABC superfamily: ATP-binding components) BN373_15901(ABC transporter, ATP-binding protein) t1858(ABC transporter ATP-binding protein) SL1344_1002(ABC transporter ATP-binding protein) Cluster1507 1 1 1 1 1 1 1 ROD_10101(putative RNA methylase) ENC_16820(23S rRNA m(2)G-2445 methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2952(Ribosomal RNA large subunit methyltransferase L,23S rRNA m(2)G2445 methyltransferase,Predicted O-methyltransferase,conserved hypothetical protein,Putative RNA methylase family UPF0020) b0948(23S rRNA mG2445 methyltransferase, SAM-dependent) BN373_15891(putative RNA methylase family UPF0020) t1859(conserved hypothetical protein) SL1344_1001(conserved hypothetical protein) Cluster1508 1 1 1 1 1 1 1 ROD_10091(putative 2Fe-2S iron-sulfur cluster binding protein) ENC_16830(Uncharacterized Fe-S protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2953(hypothetical protein,2Fe-2S ferredoxin YfaE,Uncharacterized Fe-S protein,ferredoxin [2Fe-2S],MOSC domain) b0947(predicted 2Fe-2S cluster-containing protein; 6-N-hydroxylaminopurine resistance protein) BN373_15881(MOSC domain protein) t1860(conserved hypothetical protein) SL1344_1000(conserved hypothetical protein) Cluster1509 1 1 1 1 1 1 1 ROD_10081(conserved hypothetical protein) ENC_16840(Protein of unknown function (DUF1379).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2954(Z-ring-associated protein C,Protein of unknown function (DUF1379)) b0946(FtsZ-associated protein) BN373_15871(conserved hypothetical protein) t1861(conserved hypothetical protein) SL1344_0999(conserved hypothetical protein) Cluster1510 1 1 1 1 1 1 1 ROD_10071(dihydroorotate dehydrogenase) ENC_16850(dihydroorotate oxidase A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2955(Dihydroorotate dehydrogenase (quinone),dihydroorotate dehydrogenase 2,Dihydroorotate dehydrogenase,dihydroorotate dehydrogenase (fumarate),Dihydroorotate dehydrogenase) b0945(dihydro-orotate oxidase, FMN-linked) BN373_15861(dihydroorotate oxidase) t1862(dihydroorotate dehydrogenase) SL1344_0998(dihydroorotate dehydrogenase) Cluster1511 1 1 1 1 1 1 1 ROD_10011(aminopeptidase N) ENC_16920(aminopeptidase N, Escherichia coli type) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2961(Aminopeptidase N,aminopeptidase N,aminopeptidase N,Domain of unknown function (DUF3458)) b0932(aminopeptidase N) BN373_15801(aminopeptidase N) t1863(aminopeptidase N) SL1344_0997(aminopeptidase N) Cluster1512 1 1 1 1 1 1 1 ROD_10001(nicotinate phosphoribosyltransferase) ENC_17500(nicotinate phosphoribosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2962(Nicotinate phosphoribosyltransferase,nicotinate phosphoribosyltransferase,nicotinate phosphoribosyltransferase,Nicotinate phosphoribosyltransferase (NAPRTase) family) b0931(nicotinate phosphoribosyltransferase) BN373_15791(nicotinate phosphoribosyltransferase) t1930(nicotinate phosphoribosyltransferase) SL1344_0941(nicotinate phosphoribosyltransferase (ec 2.4.2.11) (naprtase)) Cluster1513 1 1 1 1 1 1 1 ROD_09991(asparaginyl-tRNA synthetase) ENC_17510(asparaginyl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2963(Asparagine--tRNA ligase,asparaginyl-tRNA synthetase,Aspartyl/asparaginyl-tRNA synthetases,asparagine--tRNA ligase,tRNA synthetases class II (D, K and N)) b0930(asparaginyl tRNA synthetase) BN373_15731(asparaginyl-tRNA synthetase) t1934(asparaginyl-tRNA synthetase) SL1344_0937(asparaginyl-tRNA synthetase) Cluster1514 1 1 1 1 1 1 1 ROD_09971(aspartate aminotransferase) ENC_17540(Aspartate/tyrosine/aromatic aminotransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2965(Aspartate aminotransferase,aromatic amino acid aminotransferase,threonine-phosphate decarboxylase,Aminotransferase class I and II) b0928(aspartate aminotransferase, PLP-dependent) BN373_15711(aspartate transaminase) t1936(aspartate aminotransferase) SL1344_0935(aspartate aminotransferase) Cluster1515 1 1 1 1 1 1 1 ROD_09961(conserved hypothetical protein) ENC_17550(Zn-dependent hydrolases, including glyoxylases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2966(hypothetical protein,hydroxyacylglutathione hydrolase,hydroxyacylglutathione hydrolase,Metallo-beta-lactamase superfamily) b0927(predicted metal-binding enzyme) BN373_15701(metallo-beta-lactamase domain protein) t1937(conserved hypothetical protein) SL1344_0934(conserved hypothetical protein) Cluster1516 1 1 1 1 1 1 1 ROD_09951(putative exported protein) ENC_17560(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2967(Bacterial protein of unknown function (DUF882)) b0926(conserved protein) BN373_15691(Tat (twin-arginine translocation) pathway signal sequence domain/peptidase M15 family protein) t1938(putative exported protein) SL1344_0933(putative exported protein) Cluster1517 1 1 1 1 1 1 1 ROD_09941(putative exported protein) ENC_17570(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2968(murein L,D-transpeptidase,L,D-transpeptidase catalytic domain) b0925(murein L,D-transpeptidase) BN373_15681(putative peptidoglycan binding protein) t1939(putative exported protein) SL1344_0932(putative exported protein) Cluster1518 1 1 1 1 1 1 1 ROD_09921(chromosome partition protein) ENC_17580(bacterial condensin subunit MukB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2969(Structural maintenance of chromosome-related protein,cell division protein MukB,Uncharacterized protein involved in chromosome partitioning,MukB N-terminal) b0924(chromosome condensin MukBEF, ATPase and DNA-binding subunit) BN373_15671(chromosome partition protein MukB) t1940(cell division protein) SL1344_0931(cell division protein) Cluster1519 1 1 1 1 1 1 1 ROD_09911(chromosome partition protein) ENC_17590(Uncharacterized protein involved in chromosome partitioning) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2970(hypothetical protein,condesin subunit E,Uncharacterized protein involved in chromosome partitioning,MukE-like family) b0923(chromosome condensin MukBEF, MukE subunit) BN373_15661(chromosome partition protein MukE) t1941(KicA protein) SL1344_0930(KicA protein) Cluster1520 1 1 1 1 1 1 1 ROD_09901(chromosome partition protein) ENC_17600(bacterial condensin subunit MukF) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2971(hypothetical protein,condesin subunit F,KicB killing factor) b0922(chromosome condensin MukBEF, kleisin-like subunit, binds calcium) BN373_15651(chromosome partition protein MukF) t1942(killing factor KicB) SL1344_0929(killing factor KicB) Cluster1521 1 1 1 1 1 1 1 ROD_09891(putative S-adenosylmethionine-dependent methyltransferase) ENC_17610(2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2972(hypothetical protein,putative S-adenosyl-L-methionine-dependent methyltransferase,Trans-aconitate methyltransferase,3-demethylubiquinone-9 3-O-methyltransferase,Methyltransferase domain) b0921(predicted S-adenosyl-L-methionine-dependent methyltransferase) BN373_15641(SmtA protein) t1943(SmtA protein) SL1344_0928(SmtA protein) Cluster1522 1 1 1 1 1 1 1 ROD_09881(putative exported protein) ENC_17620(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2973(hypothetical protein,DUF218 domain) b0920(conserved protein, DUF218 superfamily) BN373_15631(conserved hypothetical protein) t1944(putative membrane protein) SL1344_0927(putative membrane protein) Cluster1523 1 1 1 1 1 1 1 ROD_09861(3-deoxy-manno-octulosonate cytidylyltransferase) ENC_17650(3-deoxy-D-manno-octulosonate cytidylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2975(3-deoxy-manno-octulosonate cytidylyltransferase,3-deoxy-manno-octulosonate cytidylyltransferase,Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase,3-deoxy-D-manno-octulosonate cytidylyltransferase,Cytidylyltransferase) b0918(3-deoxy-manno-octulosonate cytidylyltransferase) BN373_15611(3-deoxy-D-manno-octulosonate cytidylyltransferase) t1946(3-deoxy-manno-octulosonate cytidylyltransferase) SL1344_0925(3-deoxy-manno-octulosonate cytidylyltransferase) Cluster1524 1 1 1 1 1 1 1 ROD_09851(conserved hypothetical protein) ENC_17660(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2976(hypothetical protein,hypothetical protein,Trm112p-like protein) b0917(conserved protein, UPF0434 family) BN373_15601(conserved hypothetical protein) t1947(conserved hypothetical protein) SL1344_0924(conserved hypothetical protein) Cluster1525 1 1 1 1 1 1 1 ROD_09831(tetraacyldisaccharide 4'-kinase (lipid A 4'-kinase)) ENC_17680(lipid-A-disaccharide kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2978(Tetraacyldisaccharide 4'-kinase,tetraacyldisaccharide 4'-kinase,tetraacyldisaccharide 4'-kinase,Tetraacyldisaccharide-1-P 4'-kinase) b0915(lipid A 4'kinase) BN373_15581(tetraacyldisaccharide 4'-kinase) t1949(tetraacyldisaccharide 4'-kinase) SL1344_0922(tetraacyldisaccharide 4'-kinase) Cluster1526 1 1 1 1 1 1 1 ROD_09821(lipid A export ATP-binding/permease protein) ENC_17690(lipid A export permease/ATP-binding protein MsbA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2979(Lipid A export ATP-binding/permease protein MsbA,lipid transporter ATP-binding/permease protein,ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain,lipid A export permease/ATP-binding protein MsbA,ABC transporter transmembrane region) b0914(fused lipid transporter subunits of ABC superfamily: membrane component/ATP-binding component) BN373_15571(lipid A export permease/ATP-binding protein MsbA) t1950(probable transport ATP-binding protein MsbA) SL1344_0921(probable transport ATP-binding protein MsbA) Cluster1527 1 1 1 1 1 1 1 ROD_09811(putative competence-related protein) ENC_17700(DNA internalization-related competence protein ComEC/Rec2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2980(ComEC family competence protein,DNA internalization-related competence protein ComEC/Rec2,Competence protein) b0913(inner membrane protein, ComEC family of competence proteins) BN373_15561(DNA internalization-related competence protein ComEC/Rec2) t1951(putative competence-related protein) SL1344_0920(putative competence-related protein) Cluster1528 1 1 1 1 1 1 1 ROD_09801(integration host factor beta-subunit (IHF-beta)) ENC_17710(integration host factor, beta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2981(Integration host factor subunit beta,integration host factor subunit beta,integration host factor, beta subunit,Bacterial DNA-binding protein) b0912(integration host factor (IHF), DNA-binding protein, beta subunit) BN373_15551(integration host factor, beta subunit) t1952(integration host factor beta-subunit) SL1344_0919(integration host factor beta-subunit (IHF-beta)) Cluster1529 1 1 1 1 1 1 1 ROD_09791(30S ribosomal protein S1) ENC_17720(SSU ribosomal protein S1P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2982(30S ribosomal protein S1,30S ribosomal protein S1,Cytidylate kinase,ribosomal protein S1,S1 RNA binding domain) b0911(30S ribosomal subunit protein S1) BN373_15541(ribosomal protein S1) t1953(30S ribosomal protein S1) SL1344_0918(30S ribosomal protein S1) Cluster1530 1 1 1 1 1 1 1 ROD_09781(cytidylate kinase) ENC_17730(cytidylate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2983(Cytidylate kinase,cytidylate kinase,Cytidylate kinase,cytidylate kinase,Cytidylate kinase) b0910(cytidylate kinase) BN373_15531(cytidylate kinase) t1954(cytidylate kinase) SL1344_0917(cytidylate kinase) Cluster1531 1 1 1 1 1 1 1 ROD_09771(3-phosphoshikimate 1-carboxyvinyltransferase) ENC_17740(3-phosphoshikimate 1-carboxyvinyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3038(3-phosphoshikimate 1-carboxyvinyltransferase,bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidine monophosphate kinase,5-enolpyruvylshikimate-3-phosphate synthase,3-phosphoshikimate 1-carboxyvinyltransferase,EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)) b0908(5-enolpyruvylshikimate-3-phosphate synthetase) BN373_15521(3-phosphoshikimate 1-carboxyvinyltransferase) t1956(3-phosphoshikimate 1-carboxyvinyltransferase) SL1344_0915(3-phosphoshikimate 1-carboxyvinyltransferase) Cluster1532 1 1 1 1 1 1 1 ROD_09761(phosphoserine aminotransferase) ENC_17750(phosphoserine aminotransferase apoenzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3039(Phosphoserine aminotransferase,3-phosphoserine/phosphohydroxythreonine aminotransferase,Phosphoserine aminotransferase,phosphoserine transaminase,Aminotransferase class-V) b0907(3-phosphoserine/phosphohydroxythreonine aminotransferase) BN373_15511(phosphoserine aminotransferase) t1957(phosphoserine aminotransferase) SL1344_0914(phosphoserine aminotransferase) Cluster1533 1 1 1 1 1 1 1 ROD_09751(putative membrane protein) ENC_17770(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3040(hypothetical protein,Protein of unknown function (DUF421)) b0906(predicted inner membrane protein, UPF0702 family) BN373_15501(conserved hypothetical protein) t1958(putative membrane protein) SL1344_0913(putative membrane protein) Cluster1534 1 1 1 1 1 1 1 ROD_09741(putative fatty acid binding protein) ENC_17790(uncharacterized domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3041(conserved hypothetical protein,YcaO-like family) b0905(ribosomal protein S12 methylthiotransferase accessory factor) BN373_15491(conserved hypothetical protein) t1959(conserved hypothetical protein) SL1344_0912(conserved hypothetical protein) Cluster1535 1 1 1 1 1 1 1 ROD_09711(pyruvate formate-lyase 1 activating enzyme) ENC_17820(pyruvate formate-lyase 1-activating enzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3044(Pyruvate formate-lyase 1-activating enzyme,pyruvate formate lyase-activating enzyme 1,Predicted metal-binding protein,pyruvate formate-lyase 1-activating enzyme,Radical SAM superfamily) b0902(pyruvate formate lyase activating enzyme 1) BN373_15461(pyruvate formate-lyase 1-activating enzyme) t1964(pyruvate formate-lyase 1 activating enzyme) SL1344_0907(pyruvate formate-lyase 1 activating enzyme) Cluster1536 1 1 1 1 1 1 1 ROD_09621(major facilitator superfamily protein) ENC_17840(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3045(Uncharacterized MFS-type transporter ycaD,putative MFS family transporter protein,Arabinose efflux permease,MFS transporter, aromatic acid:H+ symporter (AAHS) family,Major Facilitator Superfamily) b0898(predicted MFS-type transporter) BN373_15451(transporter, major facilitator family) t1966(probable transport protein) SL1344_0905(probable transport protein) Cluster1537 1 0 1 1 2 1 1 ROD_09591(anaerobic dimethyl sulfoxide reductase chain B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3048(DMSO reductase iron-sulfur subunit,hydrogenase 2 protein HybA,Uncharacterized Fe-S center protein,dimethylsulfoxide reductase, chain B,4Fe-4S dicluster domain) b0895(dimethyl sulfoxide reductase, anaerobic, subunit B) BN373_15431(anaerobic dimethyl sulfoxide reductase, B subunit),BN373_21361(anaerobic dimethyl sulfoxide reductase, B subunit) t1969(anaerobic dimethyl sulfoxide reductase chain B) SL1344_0903(anaerobic dimethyl sulfoxide reductase chain B) Cluster1538 1 1 1 1 1 1 1 ROD_09571(seryl-tRNA synthetase) ENC_17880(seryl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3104(Serine--tRNA ligase,seryl-tRNA synthetase,Prolyl-tRNA synthetase,serine--tRNA ligase,tRNA synthetase class II core domain (G, H, P, S and T)) b0893(seryl-tRNA synthetase, also charges selenocysteinyl-tRNA with serine) BN373_15411(seryl-tRNA synthetase) t1971(seryl-tRNA synthetase) SL1344_0901(seryl-tRNA synthetase) Cluster1539 1 1 1 1 1 1 1 ROD_09551(outer membrane lipoprotein carrier protein) ENC_17900(periplasmic chaperone LolA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3106(P20,lipoprotein chaperone,Outer membrane lipoprotein-sorting protein,outer membrane lipoprotein carrier protein LolA,Outer membrane lipoprotein carrier protein LolA) b0891(chaperone for lipoproteins) BN373_15391(outer membrane lipoprotein carrier protein LolA) t1973(outer membrane lipoprotein carrier protein precursor) SL1344_0899(outer membrane lipoprotein carrier protein precursor) Cluster1540 1 1 1 1 1 1 1 ROD_09531(leucine-responsive regulatory protein) ENC_17930(Transcriptional regulators) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3108(Leucine-responsive regulatory protein,leucine-responsive transcriptional regulator,AsnC family) b0889(DNA-binding transcriptional dual regulator, leucine-binding) BN373_15371(leucine-responsive regulatory protein) t1975(leucine-responsive regulatory protein) SL1344_0897(leucine-responsive regulatory protein) Cluster1541 1 1 1 1 1 1 1 ROD_09521(thioredoxin reductase) ENC_17940(thioredoxin-disulfide reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3109(Thioredoxin reductase,thioredoxin reductase,Alkyl hydroperoxide reductase, large subunit,thioredoxin-disulfide reductase,Pyridine nucleotide-disulphide oxidoreductase) b0888(thioredoxin reductase, FAD/NAD(P)-binding) BN373_15361(thioredoxin-disulfide reductase) t1976(thioredoxin reductase) SL1344_0896(thioredoxin reductase) Cluster1542 1 1 1 1 1 1 1 ROD_09511(transport ATP-binding protein CydD) ENC_17950(ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3110(ATP-binding/permease protein CydD,cysteine/glutathione ABC transporter membrane/ATP-binding component,ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain,thiol reductant ABC exporter, CydD subunit,ABC transporter transmembrane region) b0887(fused glutathione, cysteine exporter subunits of ABC superfamily: membrane component/ATP-binding component) BN373_15351(ABC transporter, CydDC cysteine exporter family, permease/ATP-binding protein CydD) t1977(transport ATP-binding protein CydD) SL1344_0895(transport ATP-binding protein CydD) Cluster1543 1 1 1 1 1 1 1 ROD_09491(leucyl/phenylalanyl-tRNA-protein transferase) ENC_17980(leucyl/phenylalanyl-tRNA--protein transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3112(Leucyl/phenylalanyl-tRNA--protein transferase,leucyl/phenylalanyl-tRNA--protein transferase,Leu/Phe-tRNA-protein transferase,leucyl/phenylalanyl-tRNA--protein transferase,Leucyl/phenylalanyl-tRNA protein transferase) b0885(leucyl/phenylalanyl-tRNA-protein transferase) BN373_15331(leucyl/phenylalanyl-tRNA--protein transferase) t1979(leucyl/phenylalanyl-tRNA-protein transferase) SL1344_0893(leucyl/phenylalanyl-tRNA-protein transferase) Cluster1544 1 1 1 1 1 1 1 ROD_09485(translation initiation factor IF-1) ENC_17990(bacterial translation initiation factor 1 (bIF-1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3113(Translation initiation factor IF-1,translation initiation factor IF-1,translation initiation factor IF-1,Translation initiation factor 1A / IF-1) b0884(translation initiation factor IF-1) BN373_15321(translation initiation factor IF-1) t1980(initiation factor IF-1) SL1344_0891(initiation factor IF-1) Cluster1545 1 1 1 1 1 1 1 ROD_08931(ATP-dependent Clp protease ATP-binding subunit) ENC_18030(ATP-dependent Clp protease ATP-binding subunit ClpA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3116(ATP-dependent Clp protease ATP-binding subunit ClpA,ATP-dependent Clp protease ATP-binding subunit,Predicted ATPase,ATP-dependent Clp protease ATP-binding subunit ClpA,AAA domain (Cdc48 subfamily)) b0882(ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity) BN373_15311(ATP-dependent Clp protease ATP-binding subunit ClpA) t1988(ATP-dependent Clp protease ATP-binding subunit ClpA) SL1344_0884(ATP-dependent Clp protease ATP-binding subunit ClpA) Cluster1546 1 1 1 1 1 1 1 ROD_08921(ATP-dependent Clp protease adaptor protein) ENC_18040(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3117(ATP-dependent Clp protease adapter protein ClpS,ATP-dependent Clp protease adaptor protein ClpS,ATP-dependent Clp protease adaptor protein ClpS) b0881(regulatory protein for ClpA substrate specificity) BN373_15301(ATP-dependent Clp protease adaptor protein ClpS) t1989(conserved hypothetical protein) SL1344_0883(conserved hypothetical protein) Cluster1547 1 1 1 1 1 1 1 ROD_08911(cold shock-like protein CspD) ENC_18050(cold-shock DNA-binding protein family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3118(Cold shock-like protein CspD,stationary phase/starvation inducible regulatory protein CspD,cold shock domain protein CspD,'Cold-shock' DNA-binding domain) b0880(inhibitor of DNA replication, cold shock protein homolog) BN373_15291(cold shock domain protein CspD) t1990(cold shock-like protein CspD) SL1344_0882(cold shock-like protein CspD) Cluster1548 1 1 1 1 1 1 1 ROD_08901(macrolide export ATP-binding/permease protein) ENC_18060(ABC-type antimicrobial peptide transport system, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3119(Macrolide export ATP-binding/permease protein MacB,macrolide transporter ATP-binding /permease protein,Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component,lipoprotein releasing system, ATP-binding protein,MacB-like periplasmic core domain) b0879(fused macrolide transporter subunits of ABC superfamily: ATP-binding component/membrane component) BN373_15281(macrolide export ATP-binding/permease protein MacB) t1991(conserved hypothetical ABC transporter) SL1344_0881(conserved hypothetical ABC transporter) Cluster1549 1 1 1 1 1 1 1 ROD_08891(macrolide-specific efflux protein) ENC_18070(RND family efflux transporter, MFP subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3120(Macrolide-specific efflux protein macA precursor,macrolide transporter subunit MacA,efflux transporter, RND family, MFP subunit,HlyD family secretion protein) b0878(macrolide transporter subunit, membrane fusion protein (MFP) component) BN373_15271(macrolide-specific efflux protein MacA) t1992(putative exported protein) SL1344_0880(putative exported protein) Cluster1550 1 1 1 1 1 1 1 ROD_08871(conserved hypothetical protein) ENC_18100(Predicted ATP-dependent endonuclease of the OLD family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3122(Predicted ATPase,Protein of unknown function (DUF2813)) b0876(conserved protein with nucleoside triphosphate hydrolase domain) BN373_15261(conserved hypothetical protein) t1994(conserved hypothetical protein) SL1344_0878(conserved hypothetical protein) Cluster1551 1 1 1 1 1 1 1 ROD_08841(putative membrane protein) ENC_18120(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3124(Membrane protein of unknown function (DUF340)) b0874(predicted transporter) BN373_15241(putative membrane protein) t1995(putative membrane protein) SL1344_0877(putative membrane protein) Cluster1552 1 1 1 1 1 1 1 ROD_08831(hydroxylamine reductase) ENC_18130(hydroxylamine reductase precursor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3125(Hydroxylamine reductase,hybrid cluster protein,hydroxylamine reductase,Prismane/CO dehydrogenase family) b0873(hybrid-cluster [4Fe-2S-2O] protein in anaerobic terminal reductases) BN373_15231(hydroxylamine reductase) t1996(prismane-like protein) SL1344_0876(prismane protein homolog (hybrid-cluster protein)) Cluster1553 1 1 1 1 1 1 1 ROD_08821(NADH oxidoreductase) ENC_18140(Flavodoxin reductases (ferredoxin-NADPH reductases) family 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3126(NADH oxidoreductase hcr,HCP oxidoreductase, NADH-dependent,Uncharacterized Fe-S protein,phenylacetate-CoA oxygenase/reductase, PaaK subunit,2Fe-2S iron-sulfur cluster binding domain) b0872(HCP oxidoreductase, NADH-dependent) BN373_15221(NADH oxidoreductase hcr) t1997(NADH oxidoreductase Hcr) SL1344_0875(NADH oxidoreductase Hcr) Cluster1554 1 1 1 1 1 1 1 ROD_08801(low specificity L-threonine aldolase) ENC_18160(Threonine aldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3128(Low specificity L-threonine aldolase,L-threonine aldolase,Beta-eliminating lyase) b0870(L-allo-threonine aldolase, PLP-dependent) BN373_15191(low-specificity L-threonine aldolase) t1999(L-allo-threonine aldolase) SL1344_0873(L-allo-threonine aldolase) Cluster1555 1 1 1 1 1 1 1 ROD_08791(conserved hypothetical protein) ENC_18180(Protein of unknown function (DUF2867).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3129(short chain dehydrogenase,Putative NADH-flavin reductase,NAD dependent epimerase/dehydratase family) b0869(conserved protein with NAD(P)-binding Rossmann-fold domain) BN373_15181(NAD dependent epimerase/dehydratase family protein) t2000(conserved hypothetical protein) SL1344_0872(conserved hypothetical protein) Cluster1556 1 1 1 1 1 1 1 ROD_08781(conserved hypothetical protein) ENC_18190(Nucleoside-diphosphate-sugar epimerases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3130(Cholesterol dehydrogenase,short chain dehydrogenase,Putative NADH-flavin reductase,hopanoid-associated sugar epimerase,NAD dependent epimerase/dehydratase family) b0868(predicted NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain) BN373_15171(NAD dependent epimerase/dehydratase family) t2001(putative oxidoreductase) SL1344_0871(putative oxidoreductase) Cluster1557 1 1 1 1 1 1 1 ROD_08771(putative N-acetylmuramoyl-L-alanine amidase) ENC_18380(Negative regulator of beta-lactamase expression) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3131(N-acetylmuramoyl-L-alanine amidase AmiD precursor,N-acetyl-anhydromuranmyl-L-alanine amidase,N-acetylmuramoyl-L-alanine amidase) b0867(1,6-anhydro-N-acetylmuramyl-L-alanine amidase, Zn-dependent; OM lipoprotein) BN373_15161(N-acetylmuramoyl-L-alanine amidase amiD) t2002(putative N-acetylmuramoyl-L-alanine amidase) SL1344_0870(putative N-acetylmuramoyl-L-alanine amidase) Cluster1558 1 1 1 1 1 1 1 ROD_08751(probable lipoprotein) ENC_18400(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3133(Uncharacterized lipoprotein ybjP precursor,putative lipoprotein) b0865(lipoprotein) BN373_15131(putative lipoprotein) t2004(probable lipoprotein) SL1344_0868(probable lipoprotein) Cluster1559 1 1 1 1 1 1 1 ROD_08731(arginine ABC transporter, substrate-binding protein) ENC_18420(L-arginine-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3135(Putative ABC transporter arginine-binding protein 2 precursor,putative ABC transporter arginine-biding protein,Response regulator containing a CheY-like receiver domain and a GGDEF domain,lysine-arginine-ornithine-binding periplasmic protein,Bacterial extracellular solute-binding proteins, family 3) b0863(arginine transporter subunit) BN373_15111(arginine ABC transporter, periplasmic arginine-binding protein ArtI) t2006(arginine-binding periplasmic protein 1 precursor) SL1344_0866(arginine-binding periplasmic protein 1 precursor) Cluster1560 1 1 1 1 1 1 1 ROD_08721(arginine ABC transporter, permease protein) ENC_18430(L-arginine ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3136(Arginine ABC transporter permease protein ArtQ,arginine transporter permease subunit ArtQ,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuD,Binding-protein-dependent transport system inner membrane component) b0862(arginine transporter subunit) BN373_15101(arginine ABC transporter, permease protein ArtQ) t2007(arginine transport system permease protein ArtQ) SL1344_0865(arginine transport system permease protein ArtQ) Cluster1561 1 1 1 1 1 1 1 ROD_08711(arginine ABC transporter, permease protein) ENC_18440(L-arginine ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3137(Arginine ABC transporter permease protein ArtM,arginine transporter permease subunit ArtM,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component) b0861(arginine transporter subunit) BN373_15091(arginine ABC transporter, permease protein ArtM) t2008(arginine transport system permease protein ArtM) SL1344_0864(arginine transport system permease protein ArtM) Cluster1562 1 1 1 1 1 1 1 ROD_08701(arginine ABC transporter, substrate-binding protein) ENC_18450(L-arginine-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3138(ABC transporter arginine-binding protein 1 precursor,putative ABC transporter arginine-biding protein,Response regulator containing a CheY-like receiver domain and a GGDEF domain,lysine-arginine-ornithine-binding periplasmic protein,Bacterial extracellular solute-binding proteins, family 3) b0860(arginine binding protein, periplasmic) BN373_15081(arginine ABC transporter, periplasmic arginine-binding protein ArtJ) t2009(arginine-binding periplasmic protein 2 precursor) SL1344_0863(arginine-binding periplasmic protein 2 precursor) Cluster1563 1 1 1 1 1 1 1 ROD_08651(23S rRNA (uracil-5-)-methyltransferase) ENC_18490(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3139(23S rRNA (uracil(747)-C(5))-methyltransferase RlmC,23S rRNA methyluridine methyltransferase,Predicted O-methyltransferase,23S rRNA (uracil-5-)-methyltransferase RumB,tRNA (Uracil-5-)-methyltransferase) b0859(23S rRNA m(5)U747 methyltransferase) BN373_15051(23S rRNA (uracil-5-)-methyltransferase RumB) t2014(hypothetical RNA methyltransferase) SL1344_0859(hypothetical RNA methyltransferase) Cluster1564 1 1 1 1 1 1 1 ROD_08631(putrescine ABC transporter, permease protein) ENC_18510(ABC-type spermidine/putrescine transport system, permease component II) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3141(Inner membrane ABC transporter permease protein ydcV,putrescine transporter subunit: membrane component of ABC superfamily,ABC-type molybdate transport system, permease component,2-aminoethylphosphonate ABC transport system, membrane component PhnV,Binding-protein-dependent transport system inner membrane component) b0857(putrescine transporter subunit: membrane component of ABC superfamily) BN373_15031(putrescine ABC transporter, permease protein PotI) t2016(putrescine transport system permease protein PotI) SL1344_0857(putrescine transport system permease protein PotI) Cluster1565 1 1 1 1 1 1 1 ROD_08621(putrescine ABC transporter, permease protein) ENC_18520(ABC-type spermidine/putrescine transport system, permease component I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3142(Putrescine transport system permease protein PotH,putrescine transporter subunit: membrane component of ABC superfamily,ABC-type spermidine/putrescine transport systems, ATPase components,putative 2-aminoethylphosphonate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component) b0856(putrescine transporter subunit: membrane component of ABC superfamily) BN373_15021(putrescine ABC transporter, permease protein PotH) t2017(putrescine transport system permease protein PotH) SL1344_0856(putrescine transport system permease protein PotH) Cluster1566 1 1 1 1 1 1 1 ROD_08601(putrescine ABC transporter, substrate-binding protein) ENC_18540(Spermidine/putrescine-binding periplasmic protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3144(Putrescine-binding periplasmic protein precursor,putrescine transporter subunit: periplasmic-binding component of ABC superfamily,ABC-type uncharacterized transport system, periplasmic component,Bacterial extracellular solute-binding protein) b0854(putrescine transporter subunit: periplasmic-binding component of ABC superfamily) BN373_15001(putrescine ABC transporter, periplasmic putrescine-binding protein) t2019(putrescine-binding periplasmic protein precursor) SL1344_0854(putrescine-binding periplasmic protein precursor) Cluster1567 1 1 1 1 1 1 1 ROD_08591(conserved hypothetical protein) ENC_18550(Putative bacterial sensory transduction regulator.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3145(Putative bacterial sensory transduction regulator) b0853(predicted oxidoreductase) BN373_14991(conserved hypothetical protein) t2020(conserved hypothetical protein) SL1344_0853(conserved hypothetical protein) Cluster1568 1 1 1 1 1 1 1 ROD_08581(ribosomal protein S6 modification protein) ENC_18560(SSU ribosomal protein S6P modification protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3146(Alpha-aminoadipate--lysW ligase lysX,ribosomal protein S6 modification protein,Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase),alpha-L-glutamate ligases, RimK family,RimK-like ATP-grasp domain) b0852(ribosomal protein S6 modification protein) BN373_14981(ribosomal protein S6 modification protein) t2021(ribosomal protein S6 modification protein) SL1344_0852(ribosomal protein S6 modification protein) Cluster1569 1 1 1 1 1 1 1 ROD_08571(oxygen-insensitive NADPH nitroreductase) ENC_18570(Nitroreductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3147(Oxygen-insensitive NADPH nitroreductase,nitroreductase A,5,6-dimethylbenzimidazole synthase,Nitroreductase family) b0851(nitroreductase A, NADPH-dependent, FMN-dependent) BN373_14971(oxygen-insensitive NADPH nitroreductase) t2022(oxygen-insensitive NADPH nitroreductase) pseudoSL1344_0850(oxygen-insensitive NADPH nitroreductase (pseudogene)) Cluster1570 1 1 1 1 1 1 1 ROD_08561(glutaredoxin 1) ENC_18580(Glutaredoxin, GrxA family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3149(Glutaredoxin-1,glutaredoxin 1,glutaredoxin, GrxA family,Glutaredoxin) b0849(glutaredoxin 1, redox coenzyme for ribonucleotide reductase (RNR1a)) BN373_14951(glutaredoxin) t2024(glutaredoxin 1) SL1344_0848(glutaredoxin 1) Cluster1571 1 1 1 1 1 1 1 ROD_08551(putative membrane protein) ENC_18590(Putative inner membrane protein of Enterobacteriaceae.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3150(Inner membrane protein ybjM,Putative inner membrane protein of Enterobacteriaceae) b0848(inner membrane protein) BN373_14941(putative membrane protein) t2025(putative membrane protein) SL1344_0847(putative membrane protein) Cluster1572 2 0 2 0 1 1 1 ROD_19891(phage tail protein),ROD_36561(phage tail protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3096(Phage protein U,Phage P2 GpU),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.10(Phage protein U,Phage P2 GpU) BN373_14901(phage tail protein) t4296(putative phage tail protein) SL1344_2667(putative bacteriophage tail protein) Cluster1573 1 0 2 0 1 2 1 ROD_36621(phage tail protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3090(Bacteriophage P2-related tail formation protein,phage tail protein I,Phage tail protein (Tail_P2_I)),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.16(Bacteriophage P2-related tail formation protein,phage tail protein I,Phage tail protein (Tail_P2_I)) BN373_14811(putative prophage tail protein) t3432(putative phage tail protein),t4306(putative phage tail protein) SL1344_2677(putative bacteriophage tail protein) Cluster1574 1 0 2 0 1 2 1 ROD_36631(phage baseplate assembly protein J) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3089(Baseplate J-like protein),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.17(Baseplate J-like protein) BN373_14801(putative prophage baseplate assembly protein) t3431(phage baseplate assembly protein),t4307(probable phage baseplate assembly protein) SL1344_2678(bacteriophage baseplate assembly protein) Cluster1575 1 0 2 0 1 2 1 ROD_36731(putative capsid completion protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3079(Phage head completion protein (GPL)),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.28(Phage head completion protein (GPL)) BN373_14691(conserved hypothetical protein) t3421(putative capsid completion protein),t4317(putative capsid completion protein) SL1344_2689(putative capsid completion protein) Cluster1576 1 0 2 0 1 2 1 ROD_36741(putative small terminase subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3078(Phage small terminase subunit),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.29(Phage small terminase subunit) BN373_14681(terminase, endonuclease subunit (GpM)) t3420(terminase, endonuclease subunit),t4318(putative phage terminase) SL1344_2690(putative bacteriophage terminase) Cluster1577 1 0 2 0 1 2 1 ROD_36751(putative major capsid protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3077(phage major capsid protein, P2 family,Phage major capsid protein, P2 family),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.30(phage major capsid protein, P2 family,Phage major capsid protein, P2 family) BN373_14671(major capsid protein) t3419(major capsid protein),t4319(putative major capsid protein) SL1344_2691(putative major capsid protein) Cluster1578 2 0 1 0 1 2 1 ROD_19911(putative phage DNA replication protein),ROD_36831(putative phage DNA replication protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3068(Bacteriophage replication gene A protein (GPA)) BN373_14601(bacteriophage replication protein A) t3410(possible endonuclease),t4328(conserved hypothetical protein) SL1344_2701(predicted bacteriophage protein) Cluster1579 1 1 1 1 1 1 1 ROD_08521(TetR-family transcriptional regulator) ENC_18660(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3153(transcriptional regulator BetI,transcriptional repressor BetI,Bacterial regulatory proteins, tetR family) b0846(predicted DNA-binding transcriptional regulator) BN373_14441(transcriptional regulator, TetR family) t2027(putative TetR-family transcriptional regulator) SL1344_0845(putative tetR-family transcriptional regulator) Cluster1580 1 1 1 1 1 1 1 ROD_08511(major facilitator superfamily protein) ENC_18670(Major Facilitator Superfamily.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3154(Inner membrane protein ybjJ,putative transporter,Arabinose efflux permease,D-galactonate transporter,Major Facilitator Superfamily) b0845(predicted transporter) BN373_14431(transporter, major facilitator family) t2028(putative membrane protein) SL1344_0844(putative membrane protein) Cluster1581 1 1 1 1 1 1 1 ROD_08501(putative hydrolase) ENC_18680(HAD-superfamily hydrolase, subfamily IIB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3155(Phosphatase YbjI,sugar phosphate phosphatase,Predicted hydrolase (HAD superfamily),Cof-like hydrolase,haloacid dehalogenase-like hydrolase) b0844(FMN and erythrose-4-P phosphatase) BN373_14421(phosphatase YbjI) t2029(conserved hypothetical protein) SL1344_0843(conserved hypothetical protein) Cluster1582 1 1 1 1 1 1 1 pseudoROD_08491(multidrug translocase MdfA (pseudogene)) ENC_18690(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3157(Chloramphenicol resistance pump Cmr,multidrug efflux system translocase MdfA,Arabinose efflux permease,drug resistance transporter, Bcr/CflA subfamily,Major Facilitator Superfamily) b0842(multidrug efflux system protein) BN373_14411(multidrug translocase MdfA) t2030(multidrug translocase MdfA) SL1344_0842(multidrug translocase MdfA) Cluster1583 1 1 1 1 1 1 1 ROD_08471(putative phosphatase) ENC_18710(Undecaprenyl-diphosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3158(Putative undecaprenyl-diphosphatase ybjG,undecaprenyl pyrophosphate phosphatase,PAP2 superfamily) b0841(undecaprenyl pyrophosphate phosphatase) BN373_14401(undecaprenyl-diphosphatase) t2031(putative permease protein) SL1344_0841(putative permease protein) Cluster1584 1 1 1 1 1 1 1 ROD_08441(putative glutathione S-transferase) ENC_18740(Glutathione S-transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3161(Glutathione S-transferase GstB,putative S-transferase,maleylacetoacetate isomerase,Glutathione S-transferase, N-terminal domain) b0838(glutathione S-transferase) BN373_14361(glutathione S-transferase family protein) t2034(glutathione s-transferase family protein) SL1344_0838(glutathione s-transferase family protein) Cluster1585 1 1 1 1 1 1 1 ROD_08391(biofilm regulator) ENC_18760(Biofilm formation protein (YliH/bssR).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3163(biofilm formation regulatory protein BssR,Biofilm formation protein (YliH/bssR)) b0836(repressor of biofilm formation by indole transport regulation) BN373_14341(biofilm regulator BssR) t2036(conserved hypothetical protein) SL1344_0829(conserved hypothetical protein) Cluster1586 1 1 1 1 1 1 1 ROD_08371(ABC transporter, permease protein) ENC_18790(ABC-type dipeptide/oligopeptide/nickel transport systems, permease components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3167(Glutathione transport system permease protein gsiD,glutathione ABC transporter permease GsiD,ABC-type antimicrobial peptide transport system, permease component,nickel ABC transporter, permease subunit NikC,Binding-protein-dependent transport system inner membrane component) b0832(glutathione transporter, permease component, ABC superfamily) BN373_14311(glutathione ABC transporter, permease protein GsiD) t2038(hypothetical ABC transporter permease protein) SL1344_0827(hypothetical ABC transporter permease protein) Cluster1587 1 1 1 1 1 1 1 ROD_08361(ABC transporter, permease protein) ENC_18800(ABC-type dipeptide/oligopeptide/nickel transport systems, permease components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3168(Glutathione transport system permease protein gsiC,glutathione ABC transporter permease GsiC,nickel ABC transporter, permease subunit NikB,Binding-protein-dependent transport system inner membrane component) b0831(glutathione transporter, permease component, ABC superfamily) BN373_14301(glutathione ABC transporter, permease protein GsiC) t2039(hypothetical ABC transporter permease protein) SL1344_0826(hypothetical ABC transporter permease protein) Cluster1588 1 1 1 1 1 1 1 ROD_08351(ABC transporter, substrate-binding protein) ENC_18810(ABC-type dipeptide transport system, periplasmic component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3169(Glutathione-binding protein gsiB precursor,glutathione ABC transporter substrate-binding protein GsiB,ABC-type oligopeptide transport system, periplasmic component,nickel ABC transporter, nickel/metallophore periplasmic binding protein,Bacterial extracellular solute-binding proteins, family 5 Middle) b0830(glutathione periplasmic binding protein, ABC superfamily transporter) BN373_14291(glutathione ABC transporter, periplasmic glutathione-binding protein) t2040(putative ABC transporter periplasmic binding protein) SL1344_0825(putative ABC transporter periplasmic binding protein) Cluster1589 1 1 1 1 1 1 1 ROD_08341(ABC transporter, ATP-binding protein) ENC_18820(ATPase components of various ABC-type transport systems, contain duplicated ATPase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3170(Glutathione import ATP-binding protein GsiA,glutathione transporter ATP-binding protein,ABC-type oligopeptide transport system, ATPase component,nickel import ATP-binding protein NikD,ABC transporter) b0829(glutathione transporter ATP-binding protein, ABC superfamily) BN373_14281(glutathione ABC transporter, ATP-binding protein) t2041(hypothetical ABC transporter ATP-binding protein) SL1344_0824(hypothetical ABC transporter ATP-binding protein) Cluster1590 1 1 1 1 1 1 1 ROD_08331(putative L-asparaginase) ENC_18840(asparaginase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3171(Isoaspartyl peptidase precursor,isoaspartyl peptidase,Asparaginase) b0828(Isoaspartyl peptidase) BN373_14271(L-asparaginase) t2042(putative L-asparaginase) SL1344_0823(putative L-asparaginase) Cluster1591 1 1 1 1 1 1 1 ROD_08321(molybdopterin biosynthesis protein) ENC_18850(molybdopterin molybdochelatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3172(Molybdopterin molybdenumtransferase,molybdopterin biosynthesis protein MoeA,Molybdopterin biosynthesis enzyme,molybdenum cofactor synthesis domain,MoeA N-terminal region (domain I and II)) b0827(molybdopterin biosynthesis protein) BN373_14261(molybdopterin biosynthesis protein MoeA) t2043(molybdopterin biosynthesis MoeA protein) SL1344_0822(molybdopterin biosynthesis MoeA protein) Cluster1592 1 1 1 1 1 1 1 ROD_08311(molybdopterin biosynthesis protein) ENC_18870(Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3173(Molybdopterin-synthase adenylyltransferase,molybdopterin biosynthesis protein MoeB,molybdopterin synthase sulfurylase MoeB,ThiF family) b0826(molybdopterin synthase sulfurylase) BN373_14251(molybdopterin synthase sulfurylase MoeB) t2044(molybdopterin biosynthesis MoeB protein) SL1344_0821(molybdopterin biosynthesis MoeB protein) Cluster1593 1 1 1 1 1 1 1 ROD_08281(putative pyruvate formate-lyase 3-activating enzyme) ENC_18890(glycyl-radical enzyme activating protein family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3175(4-hydroxyphenylacetate decarboxylase activating enzyme,pyruvate formate lyase II activase,glycyl-radical enzyme activating protein family,Radical SAM superfamily) b0824(predicted pyruvate formate lyase activating enzyme) BN373_14241(glycyl-radical enzyme activating protein family) t2045(putative pyruvate formate-lyase 3 activating enzyme) SL1344_0820(putative pyruvate formate-lyase 3 activating enzyme) Cluster1594 1 1 1 1 1 1 1 ROD_08271(putative formate acetyltransferase 3 (pyruvate formate lyase 3)) ENC_18900(pyruvate formate-lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3176(4-hydroxyphenylacetate decarboxylase large subunit,putative formate acetyltransferase 2,glycyl radical enzyme, PFL2/glycerol dehydratase family,Pyruvate formate lyase) b0823(predicted pyruvate formate lyase) BN373_14231(formate C-acetyltransferase 3) t2046(putative formate acetyltransferase 3) SL1344_0819(putative formate acetyltransferase 3) Cluster1595 1 1 1 1 1 1 1 ROD_08261(putative hydrolase) ENC_18910(HAD-superfamily hydrolase, subfamily IIB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3177(Sugar phosphatase SupH,phosphoglycolate phosphatase,Predicted hydrolase (HAD superfamily),Cof-like hydrolase,haloacid dehalogenase-like hydrolase) b0822(sugar phosphatase; preference for fructose-1-P, ribose-5-P and glucose-6-P) BN373_14221(sugar phosphatase SupH) t2047(conserved hypothetical protein) SL1344_0818(conserved hypothetical protein) Cluster1596 1 1 1 1 1 1 1 ROD_08221(ABC transporter ATP-binding protein) ENC_18960(ATPase components of ABC transporters with duplicated ATPase domains) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3178(Uncharacterized ABC transporter ATP-binding protein YheS,ABC transporter ATP-binding protein,ATP-dependent transcriptional regulator,ATP-binding cassette protein, ChvD family,ABC transporter) b0820(fused predicted transporter subunits of ABC superfamily: ATP-binding components) BN373_14161(ABC transporter, ATP-binding protein) t2049(ABC transporter ATP-binding protein) SL1344_0813(ABC transporter ATP-binding protein) Cluster1597 1 1 1 1 1 1 1 ROD_08211(putative exported protein) ENC_18970(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3179(Probable L,D-transpeptidase YbiS precursor,L,D-transpeptidase,L,D-transpeptidase catalytic domain) b0819(L,D-transpeptidase linking Lpp to murein) BN373_14141(YbiS protein) t2050(putative exported protein) SL1344_0812(putative exported protein) Cluster1598 1 1 1 1 1 1 1 ROD_08201(putative exported protein) ENC_19160(transporter, YbiR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3180(Inner membrane protein YbiR,H+/gluconate symporter and related permeases,transporter, divalent anion:Na+ symporter (DASS) family,Citrate transporter) b0818(predicted transporter) BN373_14111(citrate transporter family protein) t2051(putative membrane protein) SL1344_0811(putative membrane protein) Cluster1599 1 1 1 1 1 1 1 ROD_08191(transcriptional regulator (manganese transport regulator)) ENC_19170(Mn-dependent transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3181(Manganese transport regulator,manganese transport regulator MntR,Transcriptional regulators,Iron dependent repressor, metal binding and dimerisation domain) b0817(DNA-binding transcriptional regulator of mntH) BN373_14101(transcriptional regulator MntR) t2052(transcriptional regulator) SL1344_0810(transcriptional regulator (iron dependant repressor family)) Cluster1600 1 1 1 1 1 1 1 ROD_08171(putative membrane protein) ENC_19190(Predicted membrane-associated, metal-dependent hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3183(Putative phosphoethanolamine transferase ybiP,hypothetical protein,Predicted membrane-associated, metal-dependent hydrolase,Sulfatase) b0815(predicted hydrolase, inner membrane) BN373_14081(sulfatase family protein) t2053(putative membrane protein) SL1344_0809(putative membrane protein) Cluster1601 1 1 1 1 1 1 1 ROD_08161(outer membrane protein X) ENC_19200(Opacity protein and related surface antigens) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3184(Outer membrane protein X precursor,outer membrane protein X,Opacity protein and related surface antigens,Enterobacterial Ail/Lom protein) b0814(outer membrane protein X) BN373_14071(outer membrane protein X) t2055(outer membrane protein x precursor) SL1344_0808(outer membrane protein x precursor) Cluster1602 1 1 1 1 1 1 1 ROD_08151(putative exported protein) ENC_19220(Predicted permease, DMT superfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3185(Inner membrane transporter rhtA,threonine and homoserine efflux system,Predicted permease, DMT superfamily,carboxylate/amino acid/amine transporter,EamA-like transporter family) b0813(threonine and homoserine efflux system) BN373_14061(threonine/homoserine efflux transporter RhtA) t2056(putative membrane protein) SL1344_0807(putative membrane protein) Cluster1603 1 1 1 1 1 1 1 ROD_08141(DNA protection during starvation protein) ENC_19230(DNA-binding ferritin-like protein (oxidative damage protectant)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3186(DNA protection during starvation protein,DNA starvation/stationary phase protection protein Dps,Ferritin-like domain) b0812(Fe-binding and storage protein) BN373_14051(DNA protection during starvation protein) t2057(DNA protection during starvation protein) SL1344_0806(DNA protection during starvation protein) Cluster1604 1 1 1 1 1 1 1 ROD_08121(glutamine ABC transporter, substrate-binding protein) ENC_19240(L-glutamine-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3187(Glutamine-binding periplasmic protein precursor,glutamine ABC transporter periplasmic protein,Response regulator containing a CheY-like receiver domain and a GGDEF domain,lysine-arginine-ornithine-binding periplasmic protein,Bacterial extracellular solute-binding proteins, family 3) b0811(glutamine transporter subunit) BN373_14041(glutamine ABC transporter, periplasmic glutamine-binding protein) t2058(glutamine-binding periplasmic protein precursor) SL1344_0805(glutamine-binding periplasmic protein precursor) Cluster1605 1 1 1 1 1 1 1 ROD_08071(putative zinc ion binding protein) ENC_19310(phage/conjugal plasmid C-4 type zinc finger protein, TraR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3195(hypothetical protein,hypothetical protein,DnaK suppressor protein,phage/conjugal plasmid C-4 type zinc finger protein, TraR family,Prokaryotic dksA/traR C4-type zinc finger) b0803(DksA-type zinc finger protein, function unknown) BN373_13971(C4-type zinc finger protein, DksA/TraR family) t2063(hypothetical Zinc-finger containing protein) SL1344_0800(hypothetical Zinc-finger containing protein) Cluster1606 1 1 1 1 1 1 1 ROD_08061(putative exported protein) ENC_19320(Protein of unknown function (DUF1471).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3196(Multiple stress resistance protein BhsA precursor,hypothetical protein,Protein of unknown function (DUF1471)) b0802(predicted protein) BN373_13961(conserved hypothetical protein) t2065(putative exported protein) SL1344_0799(putative exported protein) Cluster1607 1 1 1 1 1 1 1 ROD_07961(TetR-family transcriptional regulator) ENC_19420(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3202(putative DNA-binding transcriptional regulator,transcriptional repressor BetI,Domain of unknown function (DUF1956)) b0796(predicted DNA-binding transcriptional regulator) BN373_13871(transcriptional regulator, TetR family) t2069(hypothetical tetR-family transcriptional regulator) SL1344_0795(hypothetical tetR-family transcriptional regulator) Cluster1608 1 1 1 1 1 1 1 ROD_07951(putative membrane protein) ENC_19430(Multidrug resistance efflux pump) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3203(Macrolide-specific efflux protein macA precursor,putative efflux pump membrane fusion protein,efflux pump membrane protein,HlyD family secretion protein) b0795(predicted membrane fusion protein (MFP) component of efflux pump, membrane anchor) BN373_13861(auxiliary transport protein, membrane fusion protein (MFP) family) t2070(HlyD-family secretion protein) SL1344_0794(HlyD-family secretion protein) Cluster1609 1 1 1 1 1 1 1 ROD_07941(ABC transporter ATP-binding protein) ENC_19440(ABC-type multidrug transport system, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3204(Uncharacterized ABC transporter ATP-binding protein YbhF,nodulation ABC transporter NodI,ABC-type Na+ transport system, ATPase component,daunorubicin resistance ABC transporter, ATP-binding protein,ABC transporter) b0794(fused predicted transporter subunits of ABC superfamily: ATP-binding components) BN373_13851(ABC transporter, ATP-binding protein) t2071(hypothetical ABC transporter ATP-binding protein) SL1344_0793(hypothetical ABC transporter ATP-binding protein) Cluster1610 1 1 1 1 1 1 1 ROD_07931(ABC transporter, permease protein) ENC_19450(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3205(Inner membrane transport permease ybhS,ABC-type transport system involved in multi-copper enzyme maturation, permease component,ABC transporter efflux protein, DrrB family,ABC-2 family transporter protein) b0793(predicted transporter subunit: membrane component of ABC superfamily) BN373_13841(ABC-2 type transporter, permease protein) t2072(putative inner membrane protein) SL1344_0792(putative inner membrane protein) Cluster1611 1 1 1 1 1 1 1 ROD_07911(putative membrane protein) ENC_19470(Putative inner membrane protein YbhQ.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3207(Inner membrane protein ybhQ,Putative inner membrane protein YbhQ) b0791(inner membrane protein) BN373_13821(putative membrane protein) t2074(putative membrane protein) SL1344_0790(putative membrane protein) Cluster1612 1 1 1 1 1 1 1 ROD_07891(putative phospholipase) ENC_19490(Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3209(Putative cardiolipin synthase YbhO,cardiolipin synthase 2,cardiolipin synthase,Phospholipase D Active site motif) b0789(cardiolipin synthase 2) BN373_13801(putative cardiolipin synthetase) t2076(putative phospholipase) SL1344_0788(putative phospholipase) Cluster1613 1 1 1 1 1 1 1 ROD_07881(putative exported protein) ENC_19500(Predicted integral membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3210(Inner membrane protein ybhN,conserved hypothetical protein,Uncharacterised protein family (UPF0104)) b0788(conserved inner membrane protein) BN373_13791(putative membrane protein) t2077(putative membrane protein) SL1344_0787(putative membrane protein) Cluster1614 1 1 1 1 1 1 1 ROD_07861(molybdopterin converting factor, subunit 2) ENC_19520(molybdopterin synthase subunit MoaE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3213(Molybdopterin synthase catalytic subunit,molybdopterin guanine dinucleotide biosynthesis protein MoaE,Molybdopterin converting factor, large subunit,MoaE protein) b0785(molybdopterin synthase, large subunit) BN373_13771(molybdopterin converting factor, subunit 2) t2081(molybdopterin converting factor, subunit 2) SL1344_0782(molybdopterin converting factor, subunit 2) Cluster1615 1 1 1 1 1 1 1 ROD_07851(molybdopterin converting factor, subunit 1) ENC_19530(molybdopterin synthase subunit MoaD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3214(Sulfur carrier protein moaD,molybdopterin synthase small subunit,molybdopterin converting factor, subunit 1,ThiS family) b0784(molybdopterin synthase, small subunit) BN373_13761(molybdopterin converting factor, subunit 1) t2082(molybdopterin converting factor, subunit 1) SL1344_0781(molybdopterin converting factor, subunit 1) Cluster1616 1 1 1 1 1 1 1 ROD_07841(molybdenum cofactor biosynthesis protein C) ENC_19540(GTP cyclohydrolase subunit MoaC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3215(Molybdenum cofactor biosynthesis protein C,molybdenum cofactor biosynthesis protein MoaC,molybdenum cofactor biosynthesis protein C,MoaC family) b0783(molybdopterin biosynthesis, protein C) BN373_13751(molybdenum cofactor biosynthesis protein C) t2083(molybdenum cofactor biosynthesis protein C) SL1344_0780(molybdenum cofactor biosynthesis protein C) Cluster1617 1 1 1 1 1 1 1 ROD_07831(molybdenum cofactor biosynthesis protein B) ENC_19550(molybdenum cofactor biosynthesis protein B, proteobacterial) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3216(Molybdenum cofactor biosynthesis protein B,bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA,Molybdopterin biosynthesis enzyme,molybdenum cofactor biosynthesis protein B,Probable molybdopterin binding domain) b0782(molybdopterin biosynthesis protein B) BN373_13741(molybdenum cofactor biosynthesis protein B) t2084(molybdenum cofactor biosynthesis protein B) SL1344_0779(molybdenum cofactor biosynthesis protein B) Cluster1618 1 1 1 1 1 1 1 ROD_34841(putative outer membrane protein) ENC_13220(Predicted membrane-associated, metal-dependent hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4352(Phosphoethanolamine transferase eptA,putative metal dependent hydrolase,Predicted membrane-associated, metal-dependent hydrolase,Sulfatase) b4114(predicted metal dependent hydrolase) BN373_13711(membrane-associated sulfatase) t4200(putative membrane protein) SL1344_4230(putative membrane protein) Cluster1619 1 1 1 1 1 1 1 ROD_34831(two-component response regulator) ENC_34180(Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4353(Transcriptional regulatory protein BasR,DNA-binding transcriptional regulator BasR,Response regulator of citrate/malate metabolism,heavy metal response regulator,Response regulator receiver domain) b4113(DNA-binding response regulator in two-component regulatory system with BasS) BN373_13701(transcriptional regulatory protein BasR) t4199(two-component response regulator) SL1344_4229(two-component response regulator) Cluster1620 1 1 1 1 1 1 1 ROD_07801(UvrABC system protein B (excinuclease ABC subunit B)) ENC_19570(excinuclease ABC, B subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3219(Excinuclease ABC subunit B,excinuclease ABC subunit B,Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein),excinuclease ABC subunit B,Ultra-violet resistance protein B) b0779(excinulease of nucleotide excision repair, DNA damage recognition component) BN373_13681(excinuclease ABC, B subunit) t2089(excision nuclease ABC subunit B) SL1344_0775(excision nuclease ABC subunit B) Cluster1621 1 1 1 1 1 1 1 ROD_07781(biotin synthesis protein) ENC_19600(pimeloyl-CoA biosynthesis protein BioC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3221(Malonyl-CoA O-methyltransferase BioC,biotin biosynthesis protein BioC,Trans-aconitate methyltransferase,biotin biosynthesis protein BioC,Methyltransferase domain) b0777(malonyl-CoA methyltransferase, SAM-dependent) BN373_13641(biotin biosynthesis protein BioC) t2091(biotin synthesis protein BioC) SL1344_0773(biotin synthesis protein BioC) Cluster1622 1 1 1 1 1 1 1 ROD_07761(biotin synthetase) ENC_19630(biotin synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3223(Biotin synthase,biotin synthase,biotin synthase,Biotin and Thiamin Synthesis associated domain) b0775(biotin synthase) BN373_13621(biotin synthase) t2093(biotin synthetase) SL1344_0771(biotin synthetase) Cluster1623 1 1 1 1 1 1 1 ROD_07751(adenosylmethionine-8-amino-7-oxononanoate aminotransferase) ENC_19640(adenosylmethionine-8-amino-7-oxononanoate aminotransferase apoenzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3224(Adenosylmethionine-8-amino-7-oxononanoate aminotransferase,adenosylmethionine--8-amino-7-oxononanoate transaminase,Ornithine/acetylornithine aminotransferase,adenosylmethionine-8-amino-7-oxononanoate transaminase,Aminotransferase class-III) b0774(7,8-diaminopelargonic acid synthase, PLP-dependent) BN373_13611(adenosylmethionine-8-amino-7-oxononanoate transaminase) t2094(adenosylmethionine-8-amino-7-oxononanoate aminotransferase) SL1344_0770(adenosylmethionine-8-amino-7-oxononanoate aminotransferase) Cluster1624 1 1 1 1 1 1 1 ROD_07741(putative phosphatidylethanolamine-binding protein) ENC_19650(phospholipid-binding protein, PBP family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3225(hypothetical protein,putative kinase inhibitor protein,Phospholipid-binding protein,Raf kinase inhibitor-like protein, YbhB/YbcL family,Phosphatidylethanolamine-binding protein) b0773(kinase inhibitor homolog, UPF0098 family) BN373_13601(phosphatidylethanolamine-binding protein) t2095(conserved hypothetical protein) SL1344_0769(conserved hypothetical protein) Cluster1625 1 1 1 1 1 1 1 ROD_07681(acyl-CoA thioester hydrolase) ENC_19710(Pectin methylesterase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3226(Putative acyl-CoA thioester hydrolase ybhC precursor,acyl-CoA thioesterase,Pectinesterase) b0772(acyl-CoA thioesterase, lipoprotein) BN373_13531(pectinesterase) t2101(possible pectinesterase precursor) SL1344_0763(possible pectinesterase precursor) Cluster1626 1 1 1 1 1 1 1 ROD_15401(conserved hypothetical protein) ENC_13760(Biofilm development protein YmgB/AriR.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2718(Probable two-component-system connector protein AriR,Biofilm development protein YmgB/AriR) b1166(connector protein for RcsB regulation of biofilm and acid-resistance) BN373_13381(conserved hypothetical protein) t1145(hypothetical protein) SL1344_1202(hypothetical protein) Cluster1627 1 1 1 1 1 1 1 ROD_07631(6-phosphogluconolactonase) ENC_19720(3-carboxymuconate cyclase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3231(6-phosphogluconolactonase,6-phosphogluconolactona se,3-carboxymuconate cyclase,Lactonase, 7-bladed beta-propeller) b0767(6-phosphogluconolactonase) BN373_13371(6-phosphogluconolactonase) t2102(conserved hypothetical protein) SL1344_0762(conserved hypothetical protein) Cluster1628 1 1 1 1 1 1 1 ROD_07601(molybdenum ABC transporter, permease protein) ENC_19770(molybdate ABC transporter, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3234(Molybdenum transport system permease protein modB,molybdate ABC transporter permease protein,ABC-type molybdate transport system, permease component,molybdate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component) b0764(molybdate transporter subunit) BN373_13341(molybdate ABC transporter, permease protein) t2105(molybdenum transport system permease protein ModB) SL1344_0759(molybdenum transport system permease protein ModB) Cluster1629 1 1 1 1 1 1 1 ROD_07591(molybdate ABC transporter, substrate-binding protein) ENC_19780(molybdenum ABC transporter, periplasmic molybdate-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3235(Molybdate-binding periplasmic protein precursor,molybdate transporter periplasmic protein,Accessory colonization factor AcfC, contains ABC-type periplasmic domain,molybdate ABC transporter, periplasmic molybdate-binding protein,Bacterial extracellular solute-binding protein) b0763(molybdate transporter subunit) BN373_13331(molybdate ABC transporter, periplasmic molybdate-binding protein) t2106(molybdate-binding periplasmic protein precursor) SL1344_0758(molybdate-binding periplasmic protein precursor) Cluster1630 1 1 1 1 1 1 1 ROD_07581(putative membrane protein) ENC_19790(Protein of unknown function (DUF2592).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3236(Uncharacterized membrane protein ybhT,Protein of unknown function (DUF2592)) b0762(predicted protein) BN373_13321(conserved hypothetical protein) t2107(putative exported protein) SL1344_0757(putative membrane protein) Cluster1631 1 1 1 1 1 1 1 ROD_07571(transcriptional regulator) ENC_19800(ModE molybdate transport repressor domain/molybdenum-pterin binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3237(Transcriptional regulator modE,DNA-binding transcriptional regulator ModE,Molybdopterin-binding protein,ModE molybdate transport repressor domain,TOBE domain) b0761(DNA-binding transcriptional repressor for the molybdenum transport operon modABC) BN373_13311(transcriptional regulator ModE) t2108(putative molybdenum transport protein ModE) SL1344_0756(putative molybdenum transport protein ModE) Cluster1632 1 1 1 1 1 1 1 ROD_07561(putative molybdenum transport ATP-binding protein (photorepair protein PhrA)) ENC_19810(ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3238(Xylose import ATP-binding protein XylG,putative molybdenum transport ATP-binding protein ModF,ABC-type uncharacterized transport system, ATPase component,ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system,ABC transporter) b0760(fused molybdate transporter subunits of ABC superfamily: ATP-binding components) BN373_13301(putative molybdenum transport ATP-binding protein ModF) t2109(putative molybdenum transport ATP-binding protein ModF) SL1344_0755(putative molybdenum transport ATP-binding protein ModF (photorepair protein PhrA)) Cluster1633 1 1 1 1 1 1 1 ROD_07531(galactokinase) ENC_19850(galactokinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3241(Galactokinase,galactokinase,Galactokinase,galacto kinase,Galactokinase galactose-binding signature) b0757(galactokinase) BN373_13271(galactokinase) t2113(galactokinase) SL1344_0751(galactokinase) Cluster1634 1 1 1 1 1 1 1 ROD_07471(2,3-bisphosphoglycerate-dependent phosphoglycerate mutase) ENC_19870(phosphoglycerate mutase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3243(2,3-bisphosphoglycerate-dependent phosphoglycerate mutase,phosphoglyceromutase,phosphoglycerate mutase 1 family,Histidine phosphatase superfamily (branch 1)) b0755(phosphoglyceromutase 1) BN373_13251(2,3-bisphosphoglycerate-dependent phosphoglycerate mutase) t2115(phosphoglycerate mutase 1) SL1344_0749(phosphoglycerate mutase 1) Cluster1635 1 1 1 1 1 1 1 ROD_07421(phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive) ENC_19880(3-deoxy-D-arabinoheptulosonate-7-phosphate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3244(Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive,phospho-2-dehydro-3-deoxyheptonate aldolase,3-deoxy-7-phosphoheptulonate synthase,DAHP synthetase I family) b0754(3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible) BN373_13241(3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive) t2118(phospho-2-dehydro-3-deoxyheptonate aldolase) SL1344_0737(phospho-2-dehydro-3-deoxyheptonate aldolase (DAHP synthetase) phenylalanine repressible) Cluster1636 1 1 1 1 1 1 1 ROD_07401(zinc transporter) ENC_19910(cation diffusion facilitator family transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3246(Zinc transporter zitB,zinc transporter ZitB,Predicted Co/Zn/Cd cation transporters,cation diffusion facilitator family transporter,Cation efflux family) b0752(zinc efflux system) BN373_13221(zinc transporter ZitB) t2120(probable cation transport protein) SL1344_0735(probable cation transport protein) Cluster1637 1 1 1 1 1 1 1 ROD_07391(nicotinamide mononucleotide transport protein) ENC_19920(nicotinamide mononucleotide transporter PnuC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3247(Nicotinamide riboside transporter pnuC,nicotinamide riboside transporter PnuC,Nicotinamide mononucleotide transporter,nicotinamide mononucleotide transporter PnuC,Nicotinamide mononucleotide transporter) b0751(nicotinamide mononucleotide transporter) BN373_13211(nicotinamide mononucleotide transporter PnuC) t2121(pnuC protein) SL1344_0734(pnuC protein) Cluster1638 1 1 1 1 1 1 1 ROD_07381(quinolinate synthetase A) ENC_19930(quinolinate synthetase A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3248(Quinolinate synthase A,quinolinate synthetase,quinolinate synthetase complex, A subunit,Quinolinate synthetase A protein) b0750(quinolinate synthase, subunit A) BN373_13201(quinolinate synthetase complex, A subunit) t2122(quinolinate synthetase A protein) SL1344_0733(quinolinate synthetase A protein) Cluster1639 1 1 1 1 1 1 1 ROD_07361(putative tetratricopeptide repeat exported protein) ENC_19940(tol-pal system protein YbgF) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3256(hypothetical protein,tol-pal system protein YbgF,DNA uptake lipoprotein,tol-pal system protein YbgF,Tetratricopeptide repeat) b0742(periplasmic TolA-binding protein) BN373_13191(tol-pal system protein YbgF) t2126(putative exported protein) SL1344_0732(putative exported protein) Cluster1640 1 1 1 1 1 1 1 ROD_07351(peptidoglycan-associated lipoprotein) ENC_19960(peptidoglycan-associated lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3257(Peptidoglycan-associated lipoprotein precursor,peptidoglycan-associated outer membrane lipoprotein,Outer membrane protein and related peptidoglycan-associated (lipo)proteins,peptidoglycan-associated lipoprotein,OmpA family) b0741(peptidoglycan-associated outer membrane lipoprotein) BN373_13181(peptidoglycan-associated lipoprotein) t2127(peptidoglycan-associated lipoprotein precursor) SL1344_0731(peptidoglycan-associated lipoprotein precursor) Cluster1641 1 1 1 1 1 1 1 ROD_07321(colicin import protein) ENC_19990(Cell division and transport-associated protein TolR (TC 2.C.1.2.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3260(hypothetical protein,colicin uptake protein TolR,protein TolR,Biopolymer transport protein ExbD/TolR) b0738(membrane spanning protein in TolA-TolQ-TolR complex) BN373_13151(protein TolR) t2130(tolR protein) SL1344_0728(tolR protein) Cluster1642 1 1 1 1 1 1 1 ROD_07311(colicin import protein) ENC_20000(Cell division and transport-associated protein TolQ (TC 2.C.1.2.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3261(hypothetical protein,colicin uptake protein TolQ,Uncharacterized conserved protein,protein TolQ,MotA/TolQ/ExbB proton channel family) b0737(membrane spanning protein in TolA-TolQ-TolR complex) BN373_13141(protein TolQ) t2131(tolQ protein) SL1344_0727(TolQ protein) Cluster1643 1 1 1 1 1 1 1 ROD_07301(acyl-CoA thioester hydrolase) ENC_20010(conserved hypothetical protein TIGR00051) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3262(Acyl-CoA thioester hydrolase YbgC,acyl-CoA thioesterase YbgC,Acyl-ACP thioesterase,tol-pal system-associated acyl-CoA thioesterase,Thioesterase superfamily) b0736(acyl-CoA thioesterase, involved in phospholipid metabolism) BN373_13131(acyl-CoA thioesterase YbgC) t2132(conserved hypothetical protein) SL1344_0726(conserved hypothetical protein) Cluster1644 1 1 1 1 1 1 1 ROD_07291(putative exported protein) ENC_20020(cyd operon protein YbgE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3263(hypothetical protein,cyd operon protein YbgE,Cyd operon protein YbgE (Cyd_oper_YbgE)) b0735(conserved protein) BN373_13121(cyd operon protein ybge) t2133(putative membrane protein) SL1344_0725(putative membrane protein) Cluster1645 1 1 1 1 1 1 1 ROD_07281(cytochrome d ubiquinol oxidase subunit 2) ENC_20040(cytochrome bd quinol oxidase subunit 2 apoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3265(Cytochrome d ubiquinol oxidase subunit 2,cytochrome d ubiquinol oxidase subunit 2,cytochrome d ubiquinol oxidase, subunit II,Cytochrome oxidase subunit II) b0734(cytochrome d terminal oxidase, subunit II) BN373_13111(cytochrome d ubiquinol oxidase, subunit II) t2135(cytochrome d ubiquinol oxidase subunit II) SL1344_0723(cytochrome d ubiquinol oxidase subunit II) Cluster1646 1 1 1 1 1 1 1 ROD_07261(succinyl-CoA synthetase alpha chain) ENC_20090(succinyl-CoA synthetase (ADP-forming) alpha subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3271(Succinyl-CoA ligase [ADP-forming] subunit alpha,succinyl-CoA synthetase subunit alpha,Succinyl-CoA synthetase, alpha subunit,succinate-CoA ligase, alpha subunit,CoA binding domain) b0729(succinyl-CoA synthetase, NAD(P)-binding, alpha subunit) BN373_13081(succinate-CoA ligase, alpha subunit) t2137(succinyl-CoA synthetase alpha chain) SL1344_0721(succinyl-CoA synthetase alpha chain) Cluster1647 1 1 1 1 1 1 1 ROD_07241(dihydrolipoamide succinyltransferase component (E2)) ENC_20120(2-oxoglutarate dehydrogenase E2 component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3273(Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex,dihydrolipoamide succinyltransferase,Acetyl/propionyl-CoA carboxylase, alpha subunit,dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex,2-oxoacid dehydrogenases acyltransferase (catalytic domain)) b0727(dihydrolipoyltranssuccinase) BN373_13061(dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex) t2139(dihydrolipoamide succinyltransferase component) SL1344_0719(dihydrolipoamide succinyltransferase component (E2)) Cluster1648 1 1 1 1 1 1 1 ROD_07221(succinate dehydrogenase iron-sulfur protein) ENC_20140(succinate dehydrogenase subunit B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3275(Succinate dehydrogenase iron-sulfur subunit,succinate dehydrogenase iron-sulfur subunit,Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit,succinate dehydrogenase and fumarate reductase iron-sulfur protein) b0724(succinate dehydrogenase, FeS subunit) BN373_13041(succinate dehydrogenase, iron-sulfur subunit) t2141(succinate dehydrogenase iron-sulfur protein) SL1344_0717(succinate dehydrogenase iron-sulfur protein) Cluster1649 1 1 1 1 1 1 1 ROD_07211(succinate dehydrogenase flavoprotein subunit) ENC_20150(succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgroup) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3276(Succinate dehydrogenase flavoprotein subunit,succinate dehydrogenase flavoprotein subunit,Aspartate oxidase,succinate dehydrogenase, flavoprotein subunit,FAD binding domain) b0723(succinate dehydrogenase, flavoprotein subunit) BN373_13031(succinate dehydrogenase, flavoprotein subunit) t2142(succinate dehydrogenase flavoprotein subunit) SL1344_0716(succinate dehydrogenase flavoprotein subunit) Cluster1650 1 1 1 1 1 1 1 ROD_07201(succinate dehydrogenase hydrophobic membrane anchor protein) ENC_20160(succinate dehydrogenase subunit D) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3277(Succinate dehydrogenase hydrophobic membrane anchor subunit,succinate dehydrogenase cytochrome b556 small membrane subunit,succinate dehydrogenase, hydrophobic membrane anchor protein,Succinate dehydrogenase/Fumarate reductase transmembrane subunit) b0722(succinate dehydrogenase, membrane subunit, binds cytochrome b556) BN373_13021(succinate dehydrogenase, hydrophobic membrane anchor protein) t2143(succinate dehydrogenase hydrophobic membrane anchor protein) SL1344_0715(succinate dehydrogenase hydrophobic membrane anchor protein) Cluster1651 1 1 1 1 1 1 1 ROD_07191(succinate dehydrogenase cytochrome b-556 subunit) ENC_20170(succinate dehydrogenase subunit C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3278(Succinate dehydrogenase cytochrome b556 subunit,succinate dehydrogenase cytochrome b556 large membrane subunit,Succinate dehydrogenase/fumarate reductase, cytochrome b subunit,succinate dehydrogenase, cytochrome b556 subunit,Succinate dehydrogenase/Fumarate reductase transmembrane subunit) b0721(succinate dehydrogenase, membrane subunit, binds cytochrome b556) BN373_13011(succinate dehydrogenase, cytochrome b556 subunit) t2144(succinate dehydrogenase cytochrome b556 subunit) SL1344_0714(succinate dehydrogenase cytochrome b-556 subunit) Cluster1652 1 1 1 1 1 1 1 pseudoROD_07162(Endonuclease VIII (fragment)) ENC_20190(DNA-(apurinic or apyrimidinic site) lyase /endonuclease VIII) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3291(DNA glycosylase/AP lyase Nei,endonuclease VIII,formamidopyrimidine-DNA glycosylase,Formamidopyrimidine-DNA glycosylase H2TH domain) b0714(endonuclease VIII/ 5-formyluracil/5-hydroxymethyluracil DNA glycosylase) BN373_12991(endonuclease VIII) t2148(endonuclease VIII) SL1344_0710(endonuclease VIII, DNA N-glycosylase with an AP lyase activity) Cluster1653 1 1 1 1 1 1 1 ROD_07131(LamB/YcsF-family protein) ENC_20200(Uncharacterized proteins, homologs of lactam utilization protein B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3292(hypothetical protein,LamB/YcsF family protein,LamB/YcsF family) b0713(conserved protein, UPF0271 family) BN373_12951(conserved hypothetical protein) t2162(conserved hypothetical protein) SL1344_0695(conserved hypothetical protein) Cluster1654 1 1 1 1 1 1 1 ROD_07121(putative allophanate hydrolase subunit 2) ENC_20210(biotin-dependent carboxylase uncharacterized domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3293(Allophanate hydrolase subunit 2,biotin-dependent carboxylase uncharacterized domain,Allophanate hydrolase subunit 2) b0712(predicted enzyme subunit) BN373_12941(putative carboxylase) t2163(conserved hypothetical protein) SL1344_0694(conserved hypothetical protein) Cluster1655 1 1 1 1 1 1 1 ROD_07071(deoxyribodipyrimidine photolyase) ENC_20260(Deoxyribodipyrimidine photolyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3297(Deoxyribodipyrimidine photo-lyase,deoxyribodipyrimidine photolyase,deoxyribodipyrimidine photo-lyase, 8-HDF type,FAD binding domain of DNA photolyase) b0708(deoxyribodipyrimidine photolyase, FAD-binding) BN373_12901(deoxyribodipyrimidine photo-lyase) t2167(deoxyribodipyrimidine photolyase) SL1344_0690(deoxyribodipyrimidine photolyase) Cluster1656 1 1 1 1 1 1 1 ROD_07051(putative membrane protein) ENC_20280(Protein of unknown function (DUF2517).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3299(Protein of unknown function (DUF2517)) b0699(predicted protein) BN373_12891(conserved hypothetical protein) t2168(putative exported protein) SL1344_0689(putative exported protein) Cluster1657 1 1 1 1 1 1 1 ROD_07031(potassium-transporting ATPase B chain) ENC_20320(K+-transporting ATPase, B subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3301(Potassium-transporting ATPase B chain,potassium-transporting ATPase subunit B,Uncharacterized protein conserved in bacteria,K+-transporting ATPase, B subunit,E1-E2 ATPase) b0697(potassium translocating ATPase, subunit B) BN373_12871(K+-transporting ATPase, B subunit) t2170(potassium-transporting ATPase B chain) SL1344_0687(potassium-transporting ATPase B chain) Cluster1658 1 1 1 1 1 1 1 ROD_07021(potassium-transporting ATPase C chain) ENC_20330(K+-transporting ATPase, C subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3302(potassium-transporting ATPase subunit C,K+-transporting ATPase, C subunit,K+-transporting ATPase, c chain) b0696(potassium translocating ATPase, subunit C) BN373_12861(K+-transporting ATPase, C subunit) t2171(potassium-transporting ATPase C chain) SL1344_0686(potassium-transporting ATPase C chain) Cluster1659 1 1 1 1 1 1 1 ROD_07011(two-component sensor kinase) ENC_20340(Osmosensitive K+ channel histidine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3303(Sensor protein KdpD,sensor protein KdpD,Signal transduction histidine kinase regulating C4-dicarboxylate transport system,phosphate regulon sensor kinase PhoR,Osmosensitive K+ channel His kinase sensor domain) b0695(fused sensory histidine kinase in two-component regulatory system with KdpE: signal sensing protein) BN373_12851(sensor protein KdpD) t2173(sensor protein KdpD) SL1344_0685(sensor protein KdpD) Cluster1660 1 1 1 1 1 1 1 ROD_06961(phosphoglucomutase) ENC_20380(phosphoglucomutase, alpha-D-glucose phosphate-specific) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3307(Phosphoglucomutase,phosphoglucomutase,phosphogluc omutase, alpha-D-glucose phosphate-specific,Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I) b0688(phosphoglucomutase) BN373_12821(phosphoglucomutase, alpha-D-glucose phosphate-specific) t2177(phosphoglucomutase) SL1344_0680(phosphoglucomutase) Cluster1661 1 1 1 1 1 1 1 ROD_06951(negative modulator of initiation of replication) ENC_20390(negative regulator of replication initiation SeqA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3308(Negative modulator of initiation of replication,replication initiation regulator SeqA,Negative regulator of replication initiationR,SeqA protein) b0687(regulatory protein for replication initiation) BN373_12811(protein SeqA) t2178(seqA protein) SL1344_0679(seqA protein) Cluster1662 1 1 1 1 1 1 1 ROD_06941(putative esterase/lipase) ENC_20400(Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3309(Esterase ybfF,acyl-CoA esterase,Predicted dienelactone hydrolase,3-oxoadipate enol-lactonase,Alpha/beta hydrolase family) b0686(acyl-CoA esterase in vitro) BN373_12801(putative esterase YbfF) t2179(putative esterase/lipase YbfF) SL1344_0678(putative esterase/lipase YbfF) Cluster1663 1 1 1 1 1 1 1 ROD_06931(conserved hypothetical protein) ENC_20410(Ribbon-helix-helix protein, copG family.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3310(LexA regulated protein,Ribbon-helix-helix protein, copG family) b0685(LexA-regulated conserved protein) BN373_12791(ribbon-helix-helix protein, CopG family) t2180(conserved hypothetical protein) SL1344_0677(conserved hypothetical protein) Cluster1664 1 1 1 1 1 1 1 ROD_06921(flavodoxin 1) ENC_20420(flavodoxin, long chain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3311(Flavodoxin-1,flavodoxin FldA,Flavodoxin,flavodoxin,Flavodoxin) b0684(flavodoxin 1) BN373_12781(flavodoxin) t2181(flavodoxin 1) SL1344_0676(flavodoxin 1) Cluster1665 1 1 1 1 1 1 1 ROD_06911(ferric uptake regulation protein) ENC_20430(Fe2+/Zn2+ uptake regulation proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3312(Ferric uptake regulation protein,ferric uptake regulator,Ferric uptake regulator family) b0683(DNA-binding transcriptional dual regulator of siderophore biosynthesis and transport) BN373_12771(ferric uptake regulation protein) t2182(ferric uptake regulation protein) SL1344_0675(ferric uptake regulation protein) Cluster1666 1 1 1 1 1 1 1 ROD_06861(putative exported protein) ENC_20450(outer membrane porin, OprD family.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3314(outer membrane porin, OprD family) b0681(chitoporin, uptake of chitosugars) BN373_12751(outer membrane porin, OprD family) t2188(putative outer membrane protein) SL1344_0669(putative outer membrane protein) Cluster1667 1 1 1 1 1 1 1 ROD_06851(glutaminyl-tRNA synthetase) ENC_20470(glutaminyl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3315(Glutamine--tRNA ligase,glutaminyl-tRNA synthetase,Glutamyl- and glutaminyl-tRNA synthetases,glutamine--tRNA ligase,tRNA synthetases class I (E and Q), catalytic domain) b0680(glutamyl-tRNA synthetase) BN373_12741(glutaminyl-tRNA synthetase) t2189(glutaminyl-tRNA synthetase) SL1344_0668(glutaminyl-tRNA synthetase) Cluster1668 1 1 1 1 1 1 1 ROD_06781(N-acetylglucosamine repressor) ENC_20500(N-acetylglucosamine repressor, NagC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3328(Making large colonies protein,D-allose kinase,Predicted phosphosugar isomerases,ROK family protein (putative glucokinase),ROK family) b0676(DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine) BN373_12701(N-acetylglucosamine repressor) t2193(N-acetylglucosamine repressor) SL1344_0664(N-acetylglucosamine repressor) Cluster1669 1 1 1 1 1 1 1 ROD_06771(putative N-acetylglucosamine metabolism protein) ENC_20510(Predicted sugar phosphatases of the HAD superfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3329(hypothetical protein,UMP phosphatase,Glycerol dehydrogenase and related enzymes,HAD hydrolase, family IIA,haloacid dehalogenase-like hydrolase) b0675(UMP phosphatase) BN373_12691(nagD protein) t2194(NagD protein) SL1344_0663(NagD protein) Cluster1670 1 1 1 1 1 1 1 ROD_06761(asparagine synthetase B [glutamine-hydrolyzing]) ENC_20520(asparagine synthase (glutamine-hydrolysing)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3330(Asparagine synthetase B [glutamine-hydrolyzing],asparagine synthetase B,Asparagine synthase (glutamine-hydrolyzing),asparagine synthase (glutamine-hydrolyzing),Asparagine synthase) b0674(asparagine synthetase B) BN373_12681(asparagine synthase (glutamine-hydrolyzing)) t2195(asparagine synthetase B) SL1344_0662(asparagine synthetase B) Cluster1671 1 1 1 1 1 1 1 ROD_06751(2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase) ENC_20540(2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3339(2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase,2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase,Uncharacterized conserved protein,ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family,FAD binding domain) b0662(2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol oxygenase) BN373_12671(2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase) t2202(putative monooxygenase) SL1344_0660(putative monooxygenase) Cluster1672 1 1 1 1 1 1 1 ROD_06741(isopentenyl-adenosine A37 tRNA methylthiolase) ENC_20550(tRNA-i(6)A37 thiotransferase enzyme MiaB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3340((Dimethylallyl)adenosine tRNA methylthiotransferase MiaB,(dimethylallyl)adenosine tRNA methylthiotransferase,tRNA-i(6)A37 thiotransferase enzyme MiaB,Radical SAM superfamily) b0661(tRNA-i(6)A37 methylthiotransferase) BN373_12661(tRNA-i(6)A37 thiotransferase enzyme MiaB) t2203(MiaB protein) SL1344_0659(MiaB protein (putative tRNA-thiotransferase (or tRNA-methylthiotransferase))) Cluster1673 1 1 1 1 1 1 1 ROD_06711(conserved hypothetical protein) ENC_20580(conserved hypothetical protein TIGR00043) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3342(Probable rRNA maturation factor YbeY,metal-binding heat shock protein,metalloprotein, YbeY/UPF0054 family,Uncharacterized protein family UPF0054) b0659(metal-binding heat shock protein required for rRNA maturation) BN373_12641(conserved hypothetical protein TIGR00043) t2205(conserved hypothetical protein) SL1344_0657(conserved hypothetical protein) Cluster1674 1 1 1 1 1 1 1 ROD_06701(magnesium and cobalt efflux protein) ENC_20590(Putative Mg2+ and Co2+ transporter CorC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3343(Magnesium and cobalt efflux protein CorC,magnesium/cobalt efflux protein CorC,Putative Mg2+ and Co2+ transporter CorC,gliding motility-associated protein GldE,Transporter associated domain) b0658(predicteed ion transport) BN373_12631(magnesium and cobalt efflux protein CorC) t2206(haemolysin-related protein) SL1344_0656(haemolysin-related protein) Cluster1675 1 1 1 1 1 1 1 ROD_06691(apolipoprotein N-acyltransferase) ENC_20600(apolipoprotein N-acyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3344(Apolipoprotein N-acyltransferase,apolipoprotein N-acyltransferase,apolipoprotein N-acyltransferase,Carbon-nitrogen hydrolase) b0657(apolipoprotein N-acyltransferase) BN373_12621(apolipoprotein N-acyltransferase) t2207(apolipoprotein N-acyltransferase) SL1344_0655(apolipoprotein N-acyltransferase) Cluster1676 1 1 1 1 1 1 1 ROD_06671(glutamate/aspartate ABC transporter, permease protein) ENC_20620(L-glutamate ABC transporter membrane protein/L-aspartate ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3347(Inner membrane amino-acid ABC transporter permease protein yecS,glutamate/aspartate transport system permease GltK,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component) b0654(glutamate, aspartate ABC transporter permease subunit) BN373_12601(glutamate/aspartate ABC transporter, permease protein GltJ) t2209(glutamate/aspartate transport system permease protein GltJ) SL1344_0653(glutamate/aspartate transport system permease protein GltJ) Cluster1677 1 1 1 1 1 1 1 ROD_06661(glutamate/aspartate ABC transporter, permease protein) ENC_20630(L-glutamate ABC transporter membrane protein/L-aspartate ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3348(Glutamate/aspartate transport system permease protein gltK,glutamate/aspartate transport system permease GltK,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component) b0653(glutamate, aspartate ABC transporter permease subunit) BN373_12591(glutamate/aspartate ABC transporter, permease protein GltK) t2210(glutamate/aspartate transport system permease protein GltK) SL1344_0652(glutamate/aspartate transport system permease protein GltK) Cluster1678 1 1 1 1 1 1 1 ROD_06651(glutamate/aspartate ABC transporter, ATP-binding protein) ENC_20640(L-glutamate ABC transporter ATP-binding protein/L-aspartate ABC transporter ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3349(Arginine transport ATP-binding protein ArtM,glutamine ABC transporter ATP-binding protein,ABC-type histidine transport system, ATPase component,ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA,ABC transporter) b0652(glutamate, aspartate ABC transporter ATP-binding subunit) BN373_12581(glutamate/aspartate ABC transporter, ATP-binding protein) t2211(glutamate/aspartate transport ATP-binding protein GltL) SL1344_0651(glutamate/aspartate transport ATP-binding protein GltL) Cluster1679 1 1 1 1 1 1 1 ROD_06631(conserved hypothetical protein) ENC_20670(Protein of unknown function (DUF1451).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3356(hypothetical protein,Protein of unknown function (DUF1451)) b0643(conserved protein, DUF1451 family) BN373_12551(conserved hypothetical protein) t2214(conserved hypothetical protein) SL1344_0641(conserved hypothetical protein) Cluster1680 1 1 1 1 1 1 1 ROD_06621(leucyl-tRNA synthetase) ENC_20680(leucyl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3357(Leucine--tRNA ligase,leucyl-tRNA synthetase,Leucyl-tRNA synthetase,leucine--tRNA ligase,tRNA synthetases class I (I, L, M and V)) b0642(leucyl-tRNA synthetase) BN373_12541(leucyl-tRNA synthetase) t2219(leucyl-tRNA synthetase) SL1344_0636(leucyl-tRNA synthetase) Cluster1681 1 1 1 1 1 1 1 ROD_06601(DNA polymerase III, delta subunit) ENC_20700(DNA polymerase III, delta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3359(DNA polymerase III subunit delta,DNA polymerase III subunit delta,DNA polymerase III, delta subunit,DNA polymerase III, delta subunit) b0640(DNA polymerase III, delta subunit) BN373_12521(DNA polymerase III, delta subunit) t2221(DNA polymerase III, delta subunit) SL1344_0634(DNA polymerase III, delta subunit) Cluster1682 1 1 1 1 1 1 1 ROD_06591(nicotinate-nucleotide adenylyltransferase) ENC_20710(nicotinate-nucleotide adenylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3360(Nicotinate-nucleotide adenylyltransferase,nicotinic acid mononucleotide adenylyltransferase,nicotinate (nicotinamide) nucleotide adenylyltransferase,Cytidylyltransferase) b0639(nicotinic acid mononucleotide adenylyltransferase, NAD(P)-dependent) BN373_12511(nicotinate (nicotinamide) nucleotide adenylyltransferase) t2222(conserved hypothetical protein) SL1344_0633(conserved hypothetical protein) Cluster1683 1 1 1 1 1 1 1 ROD_06521(rod shape-determining protein RodA) ENC_20750(cell elongation-specific peptidoglycan biosynthesis regulator RodA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3365(Rod shape-determining protein RodA,cell wall shape-determining protein,rod shape-determining protein RodA,Cell cycle protein) b0634(cell wall shape-determining protein) BN373_12461(rod shape-determining protein RodA) t2228(rod shape-determining protein RodA) SL1344_0627(rod shape-determining protein RodA) Cluster1684 1 1 1 1 1 1 1 ROD_06511(rare lipoprotein A) ENC_20760(rare lipoprotein A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3366(Rare lipoprotein A precursor,rare lipoprotein A,Uncharacterized protein conserved in bacteria,rare lipoprotein A,Sporulation related domain) b0633(septal ring protein, suppressor of prc, minor lipoprotein) BN373_12451(rare lipoprotein A) t2229(rare lipoprotein A precursor) SL1344_0626(rare lipoprotein A precursor) Cluster1685 1 1 1 1 1 1 1 ROD_06501(penicillin-binding protein 5 (D-alanyl-D-alanine carboxypeptidase)) ENC_20770(penicillin-binding protein 6. Serine peptidase. MEROPS family S11) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3367(D-alanyl-D-alanine carboxypeptidase dacA precursor,D-alanyl-D-alanine carboxypeptidase fraction A,D-alanyl-D-alanine carboxypeptidase) b0632(D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)) BN373_12441(serine-type D-Ala-D-Ala carboxypeptidase) t2230(D-alanine carboxypeptidase) SL1344_0625(D-alanine carboxypeptidase) Cluster1686 1 1 1 1 1 1 1 ROD_06491(conserved hypothetical protein) ENC_20780(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3368(hypothetical protein,hypothetical protein,Uncharacterized conserved protein,Protein of unknown function (DUF493)) b0631(conserved protein, UPF0250 family) BN373_12431(protein YbeD) t2231(conserved hypothetical protein) SL1344_0624(conserved hypothetical protein) Cluster1687 1 1 1 1 1 1 1 ROD_06481(lipoyltransferase (lipoate-protein ligase B)) ENC_20790(lipoate-protein ligase B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3369(Octanoyltransferase,lipoate-protein ligase B,lipoyl(octanoyl) transferase,Biotin/lipoate A/B protein ligase family) b0630(octanoyltransferase; octanoyl-[ACP]:protein N-octanoyltransferase) BN373_12421(lipoyltransferase) t2232(lipoate-protein ligase B) SL1344_0623(lipoate-protein ligase B (lipoate biosynthesis protein B)) Cluster1688 1 1 1 1 1 1 1 ROD_06461(lipoic acid synthetase) ENC_20820(lipoate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3371(Lipoyl synthase,lipoyl synthase,lipoyl synthase,Radical SAM superfamily) b0628(lipoate synthase) BN373_12401(lipoic acid synthetase) t2234(lipoic acid synthetase) SL1344_0621(lipoic acid synthetase) Cluster1689 1 1 1 1 1 1 1 ROD_06411(Sec-independent protein translocase protein) ENC_20830(Sec-independent protein translocase TatE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3372(Sec-independent protein translocase protein TatE,twin arginine translocase protein E,twin arginine-targeting protein translocase, TatA/E family,mttA/Hcf106 family) b0627(TatABCE protein translocation system subunit) BN373_12391(twin arginine-targeting protein translocase, TatA/E family) t2235(sec-independent protein translocase protein TatE) SL1344_0620(sec-independent protein translocase protein TatE) Cluster1690 1 1 1 1 1 1 1 ROD_06391(putative membrane protein) ENC_20850(camphor resistance protein CrcB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3374(hypothetical protein,chromosome condensation membrane protein,protein CrcB,CrcB-like protein) b0624(inner membrane protein associated with chromosome condensation) BN373_12371(CrcB protein) t2237(putative membrane protein) SL1344_0618(putative membrane protein) Cluster1691 1 1 1 1 1 1 1 ROD_06371(putative antimicrobial peptide resistance and lipid A acylation protein) ENC_41620(Antimicrobial peptide resistance and lipid A acylation PagP) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3376(Lipid A palmitoyltransferase PagP precursor,phospholipid:lipid A palmitoyltransferase,Antimicrobial peptide resistance and lipid A acylation protein PagP) b0622(phospholipid:lipid A palmitoyltransferase) BN373_12351(antimicrobial peptide resistance and lipid A acylation protein PagP) t2239(antimicrobial peptide resistance and lipid A acylation protein) SL1344_0616(antimicrobial peptide resistance and lipid A acylation protein) Cluster1692 1 1 1 1 1 1 1 ROD_06361(anaerobic C4-dicarboxylate transporter) ENC_20970(c4-dicarboxylate anaerobic carrier family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3377(Putative cryptic C4-dicarboxylate transporter DcuD,C4-dicarboxylate transporter DcuC,C4-dicarboxylate transporter,transporter, anaerobic C4-dicarboxylate uptake C (DcuC) family,C4-dicarboxylate anaerobic carrier) b0621(anaerobic C4-dicarboxylate transport) BN373_12341(anaerobic C4-dicarboxylate transporter) t2240(C4-dicarboxylate anaerobic carrier) SL1344_0615(C4-dicarboxylate anaerobic carrier) Cluster1693 1 1 1 1 1 1 1 ROD_06261(ribonuclease I) ENC_20980(Ribonuclease I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3387(Ribonuclease I precursor,ribonuclease I,Ribonuclease I,Ribonuclease T2 family) b0611(ribonuclease I) BN373_12331(ribonuclease I) t2250(ribonuclease I precursor) SL1344_0605(ribonuclease I precursor) Cluster1694 1 1 1 1 1 1 1 ROD_06241(regulator of nucleoside diphosphate kinase) ENC_21060(Transcription elongation factor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3389(Regulator of nucleoside diphosphate kinase,nucleoside diphosphate kinase regulator,Transcription elongation factor,transcription elongation factor GreA,Transcription elongation factor, GreA/GreB, C-term) b0610(regulator of nucleoside diphosphate kinase) BN373_12321(regulator of nucleoside diphosphate kinase) t2251(regulator of nucleoside diphosphate kinase) SL1344_0604(regulator of nucleoside diphosphate kinase) Cluster1695 1 1 1 1 1 1 1 ROD_06171(alkyl hydroperoxide reductase subunit F) ENC_21110(Alkyl hydroperoxide reductase, large subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3391(Alkyl hydroperoxide reductase subunit F,alkyl hydroperoxide reductase subunit F,Alkyl hydroperoxide reductase, large subunit,alkyl hydroperoxide reductase, F subunit,Pyridine nucleotide-disulphide oxidoreductase) b0606(alkyl hydroperoxide reductase, F52a subunit, FAD/NAD(P)-binding) BN373_12301(alkyl hydroperoxide reductase subunit F) t2259(alkyl hydroperoxide reductase F52A protein subunit F) SL1344_0597(alkyl hydroperoxide reductase F52A protein (subunit F)) Cluster1696 1 1 1 1 1 1 1 ROD_06151(thiol:disulfide interchange protein) ENC_10220(Protein-disulfide isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3393(Thiol:disulfide interchange protein DsbG precursor,disulfide isomerase/thiol-disulfide oxidase,Protein-disulfide isomerase) b0604(thiol:disulfide interchange protein, periplasmic) BN373_12281(thiol:disulfide interchange protein DsbG) t2261(thiol:disulfide interchange protein DsbG precursor) SL1344_0595(thiol:disulfide interchange protein DsbG precursor) Cluster1697 1 1 1 1 1 1 1 ROD_06141(transcriptional regulator) ENC_21130(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3394(HTH-type transcriptional regulator LeuO,putative DNA-binding transcriptional regulator,D-serine deaminase transcriptional activator,Bacterial regulatory helix-turn-helix protein, lysR family) b0603(predicted DNA-binding transcriptional regulator) BN373_12271(LysR family transcriptional regulator) t2262(putative LysR-family transcriptional regulator) SL1344_0594(putative lysR-family transcriptional regulator) Cluster1698 1 1 1 1 1 1 1 ROD_06121(ParB-like nuclease) ENC_21150(Predicted transcriptional regulators) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3396(Predicted phosphoadenosine phosphosulfate sulfotransferase,ParB-like nuclease domain) b0601(conserved protein) BN373_12251(IbrB protein) t2263(conserved hypothetical protein) SL1344_0592(conserved hypothetical protein) Cluster1699 1 1 1 1 1 1 1 ROD_46031(cytosine permease) ENC_34630(Purine-cytosine permease and related proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3631(Cytosine permease,cytosine permease,NCS1 nucleoside transporter family,Permease for cytosine/purines, uracil, thiamine, allantoin) b0336(cytosine transporter) BN373_12121(permease, cytosine/purine, uracil, thiamine, allantoin family) t3250(cytosine permease) SL1344_3305(cytosine permease) Cluster1700 1 1 1 1 1 1 1 ROD_06111(conserved hypothetical protein) ENC_21340(Uncharacterized small protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3399(Uncharacterized small protein,Protein of unknown function (DUF466)) b4512(conserved protein, DUF466 family) BN373_11951(conserved hypothetical protein) t2267(conserved hypothetical protein) SL1344_0589(conserved hypothetical protein) Cluster1701 1 1 1 1 1 1 1 ROD_06061(esterase) ENC_21360(uncharacterized domain 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3401(Proofreading thioesterase EntH,thioesterase,Uncharacterized protein, possibly involved in aromatic compounds catabolism,uncharacterized domain 1,Thioesterase superfamily) b0597(thioesterase required for efficient enterobactin production) BN373_11931(putative esterase YbdB) t2269(conserved hypothetical protein) SL1344_0587(conserved hypothetical protein) Cluster1702 1 1 1 1 1 1 1 ROD_06051(2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase) ENC_21370(Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3402(2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase,2,3-dihydroxybenzoate-2,3-dehydrogenase,Uncha racterized conserved protein,3-oxoacyl-[acyl-carrier-protein] reductase,short chain dehydrogenase) b0596(2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase) BN373_11921(2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase) t2270(2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase) SL1344_0586(2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase) Cluster1703 1 1 1 1 1 1 1 ROD_06041(isochorismatase) ENC_21380(Isochorismate hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3403(Isochorismatase,putative hydrolase,pyrimidine utilization protein B,Isochorismatase family) b0595(isochorismatase) BN373_11911(isochorismatase) t2271(isochorismatase) SL1344_0585(isochorismatase) Cluster1704 1 1 1 1 1 1 1 ROD_06031(enterobactin synthetase component E) ENC_21390(2,3-dihydroxybenzoate-AMP ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3404(2,3-dihydroxybenzoate-AMP ligase,enterobactin synthase subunit E,Uncharacterized protein conserved in bacteria,(2,3-dihydroxybenzoyl)adenylate synthase,AMP-binding enzyme) b0594(2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex) BN373_11901(enterobactin synthetase, (2,3-dihydroxybenzoyl)adenylate synthase component) t2272(2,3-dihydroxybenzoate-AMP ligase) SL1344_0584(2,3-dihydroxybenzoate-AMP ligase) Cluster1705 1 1 1 1 1 1 1 ROD_06021(isochorismate synthase) ENC_21400(isochorismate synthases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3405(Isochorismate synthase entC,isochorismate synthase EntC,Anthranilate/para-aminobenzoate synthases component I,isochorismate synthase,chorismate binding enzyme) b0593(isochorismate synthase 1) BN373_11891(isochorismate synthase EntC) t2273(isochorismate synthase EntC) SL1344_0583(isochorismate synthase EntC) Cluster1706 1 1 1 1 1 1 1 ROD_06001(enterobactin exporter) ENC_21420(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3407(hypothetical protein,enterobactin exporter EntS,Arabinose efflux permease,H+ Antiporter protein,Major Facilitator Superfamily) b0591(enterobactin exporter, iron-regulated) BN373_11871(enterobactin exporter EntS) t2275(hypothetical membrane protein p43) SL1344_0581(hypothetical membrane protein p43) Cluster1707 1 1 1 1 1 1 1 ROD_05991(ferric enterobactin transport protein) ENC_21430(ABC-type Fe3+-siderophore transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3408(Ferric enterobactin transport system permease protein fepD,iron-enterobactin transporter membrane protein,ABC-type Fe3+-siderophore transport system, permease component,proposed F420-0 ABC transporter, permease protein,FecCD transport family) b0590(iron-enterobactin transporter subunit) BN373_11861(ferric enterobactin ABC transporter, permease protein FepD) t2276(ferric enterobactin transport protein FepD) SL1344_0580(ferric enterobactin transport protein FepD) Cluster1708 1 1 1 1 1 1 1 ROD_05981(ferric enterobactin transport protein) ENC_21440(ABC-type enterobactin transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3409(Ferric enterobactin transport system permease protein fepG,iron-enterobactin transporter permease,ABC-type enterobactin transport system, permease component,proposed F420-0 ABC transporter, permease protein,FecCD transport family) b0589(iron-enterobactin transporter subunit) BN373_11851(ferric enterobactin ABC transporter, permease protein FepG) t2277(ferric enterobactin transport protein FepG) SL1344_0579(ferric enterobactin transport protein FepG) Cluster1709 1 1 1 1 1 1 1 ROD_05961(enterobactin synthetase component F) ENC_21460(amino acid adenylation domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3412(Enterobactin synthase component F,enterobactin synthase subunit F,Glutamate-1-semialdehyde aminotransferase,amino acid adenylation domain,AMP-binding enzyme) b0586(enterobactin synthase multienzyme complex component, ATP-dependent) BN373_11831(enterobactin synthetase, component EntF) t2280(enterobactin synthetase component F) SL1344_0576(enterobactin synthetase component F) Cluster1710 1 1 1 1 1 1 1 ROD_05731(carboxylate-amine ligase) ENC_21800(uncharacterized enzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3429(Carboxylate-amine ligase YbdK,gamma-glutamyl:cysteine ligase,Gamma-glutamylcysteine synthetase,carboxylate-amine ligase, YbdK family,Glutamate-cysteine ligase family 2(GCS2)) b0581(weak gamma-glutamyl:cysteine ligase) BN373_11351(putative carboxylate-amine ligase ybdK) t2285(conserved hypothetical protein) SL1344_0571(conserved hypothetical protein) Cluster1711 1 1 1 1 1 1 1 ROD_05721(putative exported protein) ENC_21850(Protein of unknown function (DUF1158).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3430(Protein of unknown function (DUF1158)) b0580(predicted inner membrane protein) BN373_11291(putative lipoprotein) t2286(putative membrane protein) SL1344_0570(putative membrane protein) Cluster1712 1 1 1 1 1 1 1 ROD_05691(conserved hypothetical protein) ENC_21910(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3431(hypothetical protein,hypothetical protein,Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF419)) b0579(conserved protein) BN373_11251(conserved hypothetical protein) t2289(conserved hypothetical protein) SL1344_0567(conserved hypothetical protein) Cluster1713 1 1 1 1 1 1 1 ROD_05681(oxygen-insensitive NAD(P)H nitroreductase) ENC_21920(dihydropteridine reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3432(Oxygen-insensitive NAD(P)H nitroreductase,dihydropteridine reductase,Nitroreductase family) b0578(dihydropteridine reductase, NAD(P)H-dependent, oxygen-insensitive) BN373_11241(oxygen-insensitive NAD(P)H nitroreductase) t2290(oxygen-insensitive NAD(P)H nitroreductase) SL1344_0566(oxygen-insensitive NAD(P)H nitroreductase) Cluster1714 1 1 1 1 1 1 1 ROD_05671(putative mechanosensitive ion channel protein) ENC_21980(Small-conductance mechanosensitive channel) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3433(Miniconductance mechanosensitive channel,Mechanosensitive ion channel) b0577(mechanosensitive channel protein, miniconductance) BN373_11131(transporter, small conductance mechanosensitive ion channel (MscS) family) t2292(putative membrane protein) SL1344_0557(putative membrane protein) Cluster1715 1 1 1 1 1 1 1 ROD_50451(transthyretin-like protein) ENC_03070(hydroxyisourate hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1855(5-hydroxyisourate hydrolase precursor,hydroxyisourate hydrolase,hydroxyisourate hydrolase,HIUase/Transthyretin family) b1970(Hydroxyisourate hydrolase) BN373_10521(hydroxyisourate hydrolase) t1822(putative exported protein) SL1344_1036(putative exported protein) Cluster1716 1 0 1 1 1 1 2 ROD_47111(phage lysozyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2551(Phage-related lysozyme (muraminidase),Phage lysozyme) b0555(DLP12 prophage; predicted lysozyme) BN373_10151(phage lysozyme) t3424(putative lysozyme) SL1344_0966(putative bacteriophage lysozyme),SL1344_2576(bacteriophage lysozyme) Cluster1717 1 1 1 1 1 1 1 ROD_05611(bifunctional protein FolD) ENC_22180(methenyltetrahydrofolate cyclohydrolase /5,10-methylenetetrahydrofolate dehydrogenase (NADP+)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3449(Bifunctional protein FolD,bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase,Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain) b0529(bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase) BN373_09731(methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase) t2321(methylenetetrahydrofolate dehydrogenase) SL1344_0535(FolD bifunctional protein [includes: methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase) Cluster1718 1 1 1 1 1 1 1 ROD_05601(conserved hypothetical protein) ENC_22190(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3450(hypothetical protein,ribosome-associated protein,Uncharacterized conserved protein,S4 domain protein YaaA) b0528(Ribosome-associated protein; predicted RNA-binding protein) BN373_09721(conserved hypothetical protein) t2322(conserved hypothetical protein) SL1344_0534(conserved hypothetical protein) Cluster1719 1 1 1 1 1 1 1 ROD_05581(cysteinyl-tRNA synthetase) ENC_22230(cysteinyl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3452(Cysteine--tRNA ligase,cysteinyl-tRNA synthetase,Cysteinyl-tRNA synthetase,cysteine--tRNA ligase,tRNA synthetases class I (C) catalytic domain) b0526(cysteinyl-tRNA synthetase) BN373_09711(cysteinyl-tRNA synthetase) t2324(cysteinyl-tRNA synthetase) SL1344_0530(cysteinyl-tRNA synthetase) Cluster1720 1 1 1 1 1 1 1 ROD_05571(peptidyl-prolyl cis-trans isomerase B) ENC_22240(Peptidyl-prolyl cis-trans isomerase (rotamase)-cyclophilin family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3453(Peptidyl-prolyl cis-trans isomerase B,peptidyl-prolyl cis-trans isomerase B (rotamase B),Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD) b0525(peptidyl-prolyl cis-trans isomerase B (rotamase B)) BN373_09701(peptidylprolyl isomerase) t2325(peptidyl-prolyl cis-trans isomerase B) SL1344_0529(peptidyl-prolyl cis-trans isomerase B) Cluster1721 1 1 1 1 1 1 1 ROD_05551(phosphoribosylaminoimidazole carboxylase catalytic subunit) ENC_22260(5-(carboxyamino)imidazole ribonucleotide mutase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3456(N5-carboxyaminoimidazole ribonucleotide mutase,Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase,phosphoribosylaminoimidazole carboxylase, catalytic subunit,AIR carboxylase) b0523(N5-carboxyaminoimidazole ribonucleotide mutase) BN373_09671(phosphoribosylaminoimidazole carboxylase, catalytic subunit) t2327(phosphoribosylaminoimidazole carboxylase catalytic subunit) SL1344_0527(phosphoribosylaminoimidazole carboxylase catalytic subunit) Cluster1722 1 1 1 1 1 1 1 ROD_05531(tRNA 2-selenouridine synthase) ENC_22290(tRNA 2-selenouridine synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3476(tRNA 2-selenouridine synthase,tRNA 2-selenouridine synthase,Predicted ATPase,tRNA 2-selenouridine synthase) b0503(tRNA 2-selenouridine synthase, selenophosphate-dependent) BN373_09651(tRNA 2-selenouridine synthase) t2347(hypothetical ATP-binding protein) SL1344_0506(hypothetical ATP-binding protein) Cluster1723 1 1 1 1 1 1 1 ROD_05511(putative permease) ENC_22330(Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3481(FtsX-like permease family) b0496(predicted ABC transporter permease) BN373_09631(efflux ABC transporter, permease protein) t2352(putative membrane protein) SL1344_0501(putative membrane protein) Cluster1724 1 1 1 1 1 1 1 ROD_05501(ABC transporter, ATP-binding protein) ENC_22340(Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3482(Lipoprotein-releasing system ATP-binding protein LolD,putative ABC transporter ATP-binding protein YbbA,Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component,lipoprotein releasing system, ATP-binding protein,ABC transporter) b0495(predicted transporter subunit: ATP-binding component of ABC superfamily) BN373_09621(ABC transporter, ATP-binding protein) t2354(hypothetical ABC transporter ATP-binding protein) SL1344_0500(hypothetical ABC transporter ATP-binding protein) Cluster1725 1 1 1 1 1 1 1 ROD_05491(acyl-coA thioesterase I) ENC_22350(Lysophospholipase L1 and related esterases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3483(Acyl-CoA thioesterase I precursor,multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1,GDSL-like Lipase/Acylhydrolase) b0494(multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1) BN373_09611(acyl-CoA thioesterase I) t2353(acyl-coA thioesterase I) SL1344_0499(acyl-coA thioesterase I) Cluster1726 1 1 1 1 1 1 1 ROD_05481(putative short chain dehydrogenase) ENC_22360(Short-chain dehydrogenases of various substrate specificities) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3484(3-oxoacyl-[acyl-carrier-protein] reductase FabG,oxidoreductase,Uncharacterized conserved protein,3-oxoacyl-[acyl-carrier-protein] reductase,short chain dehydrogenase) b0493(predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain) BN373_09601(oxidoreductase, short chain dehydrogenase/reductase family) t2355(hypothetical oxidoreductase) SL1344_0498(hypothetical oxidoreductase) Cluster1727 1 1 1 1 1 1 1 ROD_05471(thioredoxin-like protein) ENC_22370(Thioredoxin domain-containing protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3485(hypothetical protein,thioredoxin 2,thioredoxin,Thioredoxin) b0492(DnaK co-chaperone, thioredoxin-like protein) BN373_09591(protein YbbN) t2356(thioredoxin-like protein) SL1344_0497(thioredoxin-like protein) Cluster1728 1 1 1 1 1 1 1 ROD_05451(putative ABC transporter, ATP-binding protein) ENC_22390(ABC-type uncharacterized transport system, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3487(Uncharacterized ABC transporter ATP-binding protein YbbL,putative ABC transporter ATP-binding protein YbbL,ABC-type spermidine/putrescine transport systems, ATPase components,thiol reductant ABC exporter, CydD subunit,ABC transporter) b0490(predicted transporter subunit: ATP-binding component of ABC superfamily) BN373_09571(ABC transporter, ATP-binding protein) t2358(putative ABC transporter ATP-binding protein) SL1344_0495(putative ABC transporter ATP-binding protein) Cluster1729 1 1 1 1 1 1 1 ROD_05441(putative membrane protein) ENC_22410(SPFH domain, Band 7 family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3488(hypothetical protein,FtsH protease regulator HflK,Uncharacterized protein conserved in bacteria,HflK protein,SPFH domain / Band 7 family) b0489(multicopy suppressor of ftsH htpX double mutant; membrane-anchored predicted protease with C-terminal cytoplasmic PHB domain) BN373_09561(SPFH domain /band 7 family protein) t2359(putative membrane protein) SL1344_0494(putative membrane protein) Cluster1730 1 1 1 1 1 1 1 ROD_05431(putative membrane protein) ENC_22420(Membrane protein implicated in regulation of membrane protease activity) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3489(Inner membrane protein ybbJ,NfeD-like C-terminal, partner-binding) b0488(inner membrane protein that stimulates the ftsH htpX mutant suppressor activity of QmcA) BN373_09551(activity regulator of membrane protease YbbK,Inner membrane protein ybbJ,NfeD-like C-terminal, partner-binding) t2360(putative membrane protein) SL1344_0493(putative membrane protein) Cluster1731 1 1 1 1 1 1 1 ROD_05391(conserved hypothetical protein) ENC_22460(Cys-tRNA(Pro) hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3498(Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase ybaK,hypothetical protein,Uncharacterized conserved protein,YbaK/EbsC protein,YbaK / prolyl-tRNA synthetases associated domain) b0481(conserved protein) BN373_09511(ybaK/ebsC protein) t2365(conserved hypothetical protein) SL1344_0488(conserved hypothetical protein) Cluster1732 1 1 1 1 1 1 1 ROD_05371(fosmidomycin resistance protein) ENC_22480(Nitrate/nitrite transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3502(Fosmidomycin resistance protein,putative 3-hydroxyphenylpropionic transporter MhpT,Arabinose efflux permease,phosphoglycerate transporter family protein,Major Facilitator Superfamily) b0479(predicted fosmidomycin efflux system) BN373_09491(fosmidomycin resistance protein) t2367(fosmidomycin resistance protein) SL1344_0486(fosmidomycin resistance protein) Cluster1733 1 1 1 1 1 1 1 ROD_05361(putative transport protein) ENC_22490(Kef-type potassium/proton antiporter, CPA2 family (TC 2.A.37.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3503(Inner membrane protein ybaL,putative cation:proton antiport protein,Kef-type K+ transport system, predicted NAD-binding component,transporter, monovalent cation:proton antiporter-2 (CPA2) family,Sodium/hydrogen exchanger family) b0478(predicted transporter with NAD(P)-binding Rossmann-fold domain) BN373_09471(transporter, monovalent cation:proton antiporter-2 family) t2368(putative transport protein) SL1344_0485(putative transport protein) Cluster1734 1 1 1 1 1 1 1 ROD_05331(ferrochelatase) ENC_22510(ferrochelatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3506(Ferrochelatase,ferrochelatase,Protoheme ferro-lyase (ferrochelatase),ferrochelatase,Ferrochelatase) b0475(ferrochelatase) BN373_09451(ferrochelatase) t2371(ferrochelatase) SL1344_0482(ferrochelatase) Cluster1735 1 1 1 1 1 1 1 ROD_05321(adenylate kinase) ENC_22520(Adenylate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3507(Adenylate kinase,adenylate kinase,adenylate kinase,Adenylate kinase) b0474(adenylate kinase) BN373_09441(adenylate kinase) t2372(adenylate kinase) SL1344_0481(adenylate kinase) Cluster1736 1 1 1 1 1 1 1 ROD_05311(chaperone (heat shock protein)) ENC_22530(Molecular chaperone, HSP90 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3508(High temperature protein G,heat shock protein 90,Molecular chaperone, HSP90 family,Hsp90 protein) b0473(protein refolding molecular co-chaperone Hsp90, Hsp70-dependent; heat-shock protein; ATPase) BN373_09431(chaperone protein HtpG) t2373(heat shock protein HtpG) SL1344_0480(heat shock protein HtpG) Cluster1737 1 1 1 1 1 1 1 ROD_05301(recombination protein) ENC_22540(DNA replication and repair protein RecR) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3509(Recombination protein RecR,recombination protein RecR,Recombinational DNA repair protein (RecF pathway),recombination protein RecR,RecR protein) b0472(gap repair protein) BN373_09421(recombination protein RecR) t2374(recombination protein RecR) SL1344_0479(recombination protein RecR) Cluster1738 1 1 1 1 1 1 1 ROD_05291(conserved hypothetical protein) ENC_22550(conserved hypothetical protein TIGR00103) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3510(hypothetical protein,hypothetical protein,DNA-binding protein, YbaB/EbfC family,Uncharacterised BCR, YbaB family COG0718) b0471(conserved protein) BN373_09411(conserved hypothetical protein TIGR00103) t2375(conserved hypothetical protein) SL1344_0478(conserved hypothetical protein) Cluster1739 1 1 1 1 1 1 1 ROD_05271(adenine phosphoribosyltransferase) ENC_22580(adenine phosphoribosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3512(Adenine phosphoribosyltransferase,adenine phosphoribosyltransferase,GTP cyclohydrolase I,adenine phosphoribosyltransferase,Phosphoribosyl transferase domain) b0469(adenine phosphoribosyltransferase) BN373_09391(adenine phosphoribosyltransferase) t2377(adenine phosphoribosyltransferase) SL1344_0476(adenine phosphoribosyltransferase) Cluster1740 1 1 1 1 1 1 1 ROD_05191(acrAB operon repressor) ENC_22630(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3517(Potential acrAB operon repressor,DNA-binding transcriptional repressor AcrR,mycofactocin system transcriptional regulator,MAATS-type transcriptional repressor, C-terminal region) b0464(DNA-binding transcriptional repressor) BN373_09331(transcriptional regulator AcrR) t2383(potential acrAB operon repressor) SL1344_0470(potential acrAB operon repressor) Cluster1741 1 1 1 1 1 1 1 ROD_05161(conserved hypothetical protein) ENC_22680(Biofilm formation regulator YbaJ.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3520(Toxin overexpression modulator in biofilms,Hha toxicity attenuator,Biofilm formation regulator YbaJ) b0461(Hha toxicity attenuator; conjugation-related protein) BN373_09301(conserved hypothetical protein) t2386(conserved hypothetical protein) SL1344_0467(conserved hypothetical protein) Cluster1742 1 1 1 1 1 1 1 ROD_05151(haemolysin expression regulatory protein) ENC_22690(Haemolysin expression modulating protein.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3521(Hemolysin expression-modulating protein Hha,gene expression modulator,Haemolysin expression modulating protein) b0460(modulator of gene expression, with H-NS) BN373_09291(haemolysin expression modulating protein) t2387(haemolysin expression modulating protein) SL1344_0466(haemolysin expression modulating protein) Cluster1743 1 1 1 1 1 1 1 ROD_05141(maltose O-acetyltransferase) ENC_22700(Acetyltransferase (isoleucine patch superfamily)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3522(Maltose O-acetyltransferase,maltose O-acetyltransferase,Acetyltransferase (isoleucine patch superfamily),sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family,Maltose acetyltransferase) b0459(maltose O-acetyltransferase) BN373_09281(maltose O-acetyltransferase) t2388(maltose O-acetyltransferase) SL1344_0465(maltose O-acetyltransferase) Cluster1744 1 1 1 1 1 1 1 ROD_05131(putative membrane protein) ENC_22710(Extracytoplasmic function sigma factor YlaC.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3523(Inner membrane protein ylaC,Extracytoplasmic function sigma factor YlaC) b0458(inner membrane protein, DUF1449 family) BN373_09271(conserved hypothetical protein) t2389(putative membrane protein) SL1344_0464(putative membrane protein) Cluster1745 1 1 1 1 1 1 1 ROD_05121(putative signal transduction protein) ENC_22780(Predicted signal transduction protein containing sensor and EAL domains) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3524(Uncharacterized membrane protein YjcC,phage resistance protein,Predicted signal transduction protein containing sensor and EAL domains,EAL domain) b0457(predicted cyclic-di-GMP phosphodiesterase) BN373_09131(cyclic diguanylate phosphodiesterase (EAL) domain protein) t2392(hypothetical 58.9 kDa protein) SL1344_0461(hypothetical 58.9 kDa protein in tesb-hha intergenic region. Contains probable N-terminal signal sequence) Cluster1746 1 1 1 1 1 1 1 ROD_29021(conserved hypothetical protein) ENC_22790(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1608(Transcriptional repressor rcnR,transcriptional repressor RcnR to maintain nickel and cobalt homeostasis,Uncharacterised BCR, COG1937) b2105(DNA-binding transcriptional repressor of rcnA) BN373_09121(transcriptional repressor RcnR) t2933(conserved hypothetical protein) SL1344_3001(conserved hypothetical protein) Cluster1747 1 1 1 1 1 1 1 ROD_05101(putative methyltransferase) ENC_22870(O(6)-alkylguanine repair protein YbaZ) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3527(Methylated-DNA--protein-cysteine methyltransferase,O-6-alkylguanine-DNA:cysteine-protein methyltransferase,Predicted methylated DNA-protein cysteine methyltransferase,methylated-DNA-[protein]-cysteine S-methyltransferase,6-O-methylguanine DNA methyltransferase, DNA binding domain) b0454(binds and enhances nucleotide excision repair of O(6)-alkylguanine; degenerate cysteine methyltransferase homolog) BN373_09061(methylated-DNA-[protein]-cysteine S-methyltransferase) t2393(putative methylated-DNA methyltransferase) SL1344_0460(putative methylated-DNA methyltransferase) Cluster1748 1 1 1 1 1 1 1 ROD_05081(acyl-CoA thioesterase II) ENC_22900(acyl-CoA thioesterase II) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3529(Acyl-CoA thioesterase 2,acyl-CoA thioesterase II,acyl-CoA thioesterase II,Acyl-CoA thioesterase) b0452(acyl-CoA thioesterase II) BN373_09041(acyl-CoA thioesterase II) t2395(acyl-CoA thioesterase II) SL1344_0458(acyl-CoA thioesterase II) Cluster1749 1 1 1 1 1 1 1 ROD_05061(ammonia channel precursor (ammonia transporter)) ENC_22910(ammonium transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3530(Ammonia transporter,ammonium transporter,Ammonia permease,ammonium transporter,Ammonium Transporter Family) b0451(ammonium transporter) BN373_09031(ammonium transporter) t2396(probable ammonium transporter) SL1344_0457(probable ammonium transporter) Cluster1750 1 1 1 1 1 1 1 ROD_05051(nitrogen regulatory protein P-II) ENC_22920(Nitrogen regulatory protein PII) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3531(Nitrogen regulatory protein P-II 2,nitrogen regulatory protein P-II 2,Nitrogen regulatory protein P-II) b0450(nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB) BN373_09021(nitrogen regulatory protein P-II 2) t2397(nitrogen regulatory protein P-II) SL1344_0456(nitrogen regulatory protein P-II) Cluster1751 1 1 1 1 1 1 1 ROD_05041(putative ABC transporter, ATP-binding/permease protein) ENC_22930(ABC-type multidrug transport system, ATPase and permease components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3532(Multidrug resistance-like ATP-binding protein MdlB,putative multidrug transporter membrane\ATP-binding components,ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain,lipid A export permease/ATP-binding protein MsbA,ABC transporter transmembrane region) b0449(fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components) BN373_09011(multidrug ABC transporter, permease/ATP-binding protein) t2398(putative ABC transporter ATP-binding membrane protein) SL1344_0455(putative ABC transporter ATP-binding membrane protein) Cluster1752 1 1 1 1 1 1 1 ROD_05022(putative transcriptional regulator) ENC_22960(transcriptional regulator, AsnC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3534(Leucine-responsive regulatory protein,leucine-responsive transcriptional regulator,AsnC family) b0447(predicted DNA-binding transcriptional regulator) BN373_08991(transcriptional regulator, AsnC family) t2400(hypothetical transcriptional regulator) SL1344_0453(hypothetical transcriptional regulator) Cluster1753 1 1 1 1 1 1 1 ROD_05011(putative hydrolase) ENC_22980(HAD-superfamily hydrolase, subfamily IIB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3535(HMP-PP phosphatase,thiamin pyrimidine pyrophosphate hydrolase,Predicted hydrolase (HAD superfamily),Cof-like hydrolase,haloacid dehalogenase-like hydrolase) b0446(thiamin pyrimidine pyrophosphate hydrolase; HMP-PP phosphatase) BN373_08971(hydrolase Cof) t2403(conserved hypothetical protein) SL1344_0451(conserved hypothetical protein) Cluster1754 1 1 1 1 1 1 1 ROD_05001(putative substrate-binding protein) ENC_22990(ABC-type uncharacterized transport system, periplasmic component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3536(HTH-type transcriptional regulator sgrR,transcriptional regulator SgrR,ABC-type uncharacterized transport system, periplasmic component,Sugar transport-related sRNA regulator N-term) b0445(predicted transporter subunit: periplasmic-binding component of ABC superfamily) BN373_08961(putative periplasmic solute-binding protein) t2404(putative solute-binding protein) SL1344_0450(putative solute-binding protein) Cluster1755 1 1 1 1 1 1 1 ROD_04991(queuosine biosynthesis protein) ENC_23000(preQ(0) biosynthesis protein QueC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3537(7-cyano-7-deazaguanine synthase,queuosine biosynthesis protein QueC,ATP-utilizing enzymes of the PP-loop superfamily,queuosine biosynthesis protein QueC,ExsB) b0444(7-cyano-7-deazaguanine (preQ0) synthase; queuosine biosynthesis) BN373_08951(queuosine biosynthesis protein QueC) t2405(conserved hypothetical protein) SL1344_0449(conserved hypothetical protein) Cluster1756 1 1 1 1 1 1 1 ROD_04981(conserved hypothetical protein) ENC_23010(conserved hypothetical protein TIGR00051) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3538(Long-chain acyl-CoA thioesterase FadM,acyl-CoA thioesterase YbgC,Acyl-ACP thioesterase,acyl-CoA thioester hydrolase, YbgC/YbaW family,Acyl-ACP thioesterase) b0443(long-chain acyl-CoA thioesterase III) BN373_08941(thioesterase family protein) t2406(conserved hypothetical protein) SL1344_0448(conserved hypothetical protein) Cluster1757 1 1 1 1 1 1 1 ROD_04971(putative DNA uptake protein) ENC_23020(competence protein ComEA helix-hairpin-helix repeat region) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3539(hypothetical protein,competence protein ComEA helix-hairpin-helix repeat region,Helix-hairpin-helix motif) b0442(conserved protein, ComEA homolog) BN373_08931(competence protein ComEA homolog) t2407(putative exported protein) SL1344_0447(putative exported protein) Cluster1758 1 1 1 1 1 1 1 ROD_04961(peptidyl-prolyl cis-trans isomerase D) ENC_23030(Parvulin-like peptidyl-prolyl isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3540(Peptidyl-prolyl cis-trans isomerase D,periplasmic folding chaperone,nitrogen fixation protein NifM,PPIC-type PPIASE domain) b0441(periplasmic folding chaperone, has an inactive PPIase domain) BN373_08921(peptidylprolyl isomerase) t2408(peptidyl-prolyl cis-trans isomerase D) SL1344_0446(peptidyl-prolyl cis-trans isomerase D) Cluster1759 1 1 1 1 1 1 1 ROD_04941(ATP-dependent protease La) ENC_23050(ATP-dependent proteinase. Serine peptidase. MEROPS family S16) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3542(Lon protease,DNA-binding ATP-dependent protease La,Archaeal serine proteases,ATP-dependent protease La,Lon protease (S16) C-terminal proteolytic domain) b0439(DNA-binding ATP-dependent protease La) BN373_08901(ATP-dependent protease La) t2410(Lon protease) SL1344_0444(Lon protease) Cluster1760 1 1 1 1 1 1 1 ROD_04931(ATP-dependent Clp protease ATP-binding subunit) ENC_23060(ATP-dependent Clp protease ATP-binding subunit ClpX) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3544(ATP-dependent Clp protease ATP-binding subunit ClpX,ATP-dependent protease ATP-binding subunit ClpX,DnaK suppressor protein,ATP-dependent Clp protease, ATP-binding subunit ClpX,AAA domain (Cdc48 subfamily)) b0438(ATPase and specificity subunit of ClpX-ClpP ATP-dependent serine protease) BN373_08891(ATP-dependent Clp protease, ATP-binding subunit ClpX) t2411(ATP-dependent clp protease ATP-binding subunit ClpX) SL1344_0443(ATP-dependent clp protease ATP-binding subunit ClpX) Cluster1761 1 1 1 1 1 1 1 ROD_04921(ATP-dependent clp protease proteolytic subunit) ENC_44340(Protease subunit of ATP-dependent Clp proteases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3545(ATP-dependent Clp protease proteolytic subunit precursor,ATP-dependent Clp protease proteolytic subunit,ATP-dependent Clp endopeptidase, proteolytic subunit ClpP,Clp protease) b0437(proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP-dependent serine proteases) BN373_08881(ATP-dependent Clp protease, proteolytic subunit ClpP) t2412(ATP-dependent clp protease proteolytic subunit) SL1344_0442(ATP-dependent clp protease proteolytic subunit) Cluster1762 1 1 1 1 1 1 1 ROD_04911(trigger factor) ENC_23090(trigger factor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3546(Trigger factor,trigger factor,FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor),trigger factor,Bacterial trigger factor protein (TF)) b0436(peptidyl-prolyl cis/trans isomerase (trigger factor)) BN373_08871(trigger factor) t2413(trigger factor) SL1344_0441(trigger factor) Cluster1763 1 1 1 1 1 1 1 ROD_04901(putative transcriptional regulator) ENC_23100(transcriptional regulator, BolA protein family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3547(hypothetical protein,transcriptional regulator BolA,Predicted transcriptional regulator, BolA superfamily,BolA-like protein) b0435(stationary-phase morphogene, transcriptional repressor for mreB; also regulator for dacA, dacC, and ampC) BN373_08861(protein BolA) t2414(BolA protein) SL1344_0440(BolA protein) Cluster1764 1 1 1 1 1 1 1 ROD_04891(putative exported protein) ENC_23110(Uncharacterized lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3548(hypothetical protein,Uncharacterized lipoprotein,Uncharacterized lipoprotein) b0434(predicted lipoprotein) BN373_08851(putative lipoprotein) t2415(putative lipoprotein) SL1344_0439(putative lipoprotein) Cluster1765 1 1 1 1 1 1 1 ROD_04881(peptidoglycan monomer (N-acetylglucosamine-1,6-anhydro-N-acetylmuramic acid-tetrapeptide) uptake protein (major facilitator superfamily protein)) ENC_23120(AmpG-related permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3549(hypothetical protein,muropeptide transporter,Arabinose efflux permease,AmpG-like permease,Major Facilitator Superfamily) b0433(muropeptide transporter) BN373_08841(AmpG protein) t2416(AmpG protein) SL1344_0438(muropeptide MFS transporter protein) Cluster1766 1 1 1 1 1 1 1 ROD_04871(cytochrome o ubiquinol oxidase subunit 2) ENC_23130(cytochrome bo3 quinol oxidase subunit 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3550(Ubiquinol oxidase subunit 2 precursor,cytochrome o ubiquinol oxidase subunit II,ubiquinol oxidase, subunit II,COX Aromatic Rich Motif) b0432(cytochrome o ubiquinol oxidase subunit II) BN373_08831(cytochrome o ubiquinol oxidase, subunit II) t2417(cytochrome o ubiquinol oxidase subunit II) SL1344_0437(cytochrome o ubiquinol oxidase subunit II) Cluster1767 1 1 1 1 1 1 1 ROD_04851(cytochrome o ubiquinol oxidase subunit 3) ENC_23160(cytochrome bo3 quinol oxidase subunit 3) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3552(Cytochrome o ubiquinol oxidase subunit 3,cytochrome o ubiquinol oxidase subunit III,cytochrome o ubiquinol oxidase, subunit III,Cytochrome c oxidase subunit III) b0430(cytochrome o ubiquinol oxidase subunit III) BN373_08811(cytochrome o ubiquinol oxidase, subunit III) t2419(cytochrome o ubiquinol oxidase subunit III) SL1344_0435(cytochrome o ubiquinol oxidase subunit III) Cluster1768 1 1 1 1 1 1 1 ROD_04842(cytochrome o ubiquinol oxidase subunit IV) ENC_23170(cytochrome bo3 quinol oxidase subunit 4) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3553(Cytochrome o ubiquinol oxidase protein CyoD,cytochrome o ubiquinol oxidase subunit IV,cytochrome o ubiquinol oxidase subunit IV,Prokaryotic Cytochrome C oxidase subunit IV) b0429(cytochrome o ubiquinol oxidase subunit IV) BN373_08801(cytochrome o ubiquinol oxidase, subunit IV) t2420(cytochrome o ubiquinol oxidase C subunit) SL1344_0434(cytochrome o ubiquinol oxidase C subunit) Cluster1769 1 1 1 1 1 1 1 ROD_04841(protoheme IX farnesyltransferase (heme O synthase)) ENC_23180(protoheme IX farnesyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3554(Protoheme IX farnesyltransferase,protoheme IX farnesyltransferase,Polyprenyltransferase (cytochrome oxidase assembly factor),protoheme IX farnesyltransferase,UbiA prenyltransferase family) b0428(protoheme IX farnesyltransferase) BN373_08791(protoheme IX farnesyltransferase) t2421(cytochrome o ubiquinol oxidase C subunit) SL1344_0433(cytochrome o ubiquinol oxidase C subunit) Cluster1770 1 1 1 1 1 1 1 ROD_04761(Major facilitator superfamily transporter) ENC_23290(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3555(Inner membrane transport protein yajR,bicyclomycin/multidrug efflux system,Arabinose efflux permease,multidrug resistance protein,Major Facilitator Superfamily) b0427(predicted transporter) BN373_08691(transporter, major facilitator family) t2427(hypothetical major facilitator family transport protein) SL1344_0430(hpothetical major facilitator family transport protein) Cluster1771 1 1 1 1 1 1 1 ROD_04751(conserved hypothetical protein) ENC_23300(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3556(hypothetical protein,putative nucleotide-binding protein,Arsenate reductase and related proteins, glutaredoxin family,Protein of unknown function (DUF520)) b0426(Phi6 host factor; binds ATP and GTP) BN373_08681(conserved hypothetical protein) t2428(conserved hypothetical protein) SL1344_0429(conserved hypothetical protein) Cluster1772 1 1 1 1 1 1 1 ROD_04731(4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein) ENC_23320(DJ-1 family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3558(Chaperone protein YajL,oxidative-stress-resistance chaperone,Uncharacterized protein conserved in bacteria,DJ-1 family protein,DJ-1/PfpI family) b0424(Oxidative-stress-resistance chaperone) BN373_08661(protein ThiJ) t2429(4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein) SL1344_0427(4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis (ThiJ) protein) Cluster1773 1 1 1 1 1 1 1 ROD_04721(thiamine biosynthesis protein ThiI) ENC_23370([ThiS-adenylate] sulfurtransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3559(tRNA sulfurtransferase,tRNA s(4)U8 sulfurtransferase,tRNA sulfurtransferase ThiI,Thiamine biosynthesis protein (ThiI)) b0423(tRNA s(4)U8 sulfurtransferase) BN373_08641(thiamine biosynthesis/tRNA modification protein ThiI) t2438(thiamine biosynthesis protein ThiI) SL1344_0419(thiamine biosynthesis protein ThiI) Cluster1774 1 1 1 1 1 1 1 ROD_04711(exodeoxyribonuclease 7 small subunit) ENC_23380(Exodeoxyribonuclease VII small subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3560(Exodeoxyribonuclease 7 small subunit,exodeoxyribonuclease VII small subunit,exodeoxyribonuclease VII, small subunit,Exonuclease VII small subunit) b0422(exonuclease VII small subunit) BN373_08631(exodeoxyribonuclease VII, small subunit) t2439(exodeoxyribonuclease small subunit) SL1344_0418(exodeoxyribonuclease small subunit) Cluster1775 1 1 1 1 1 1 1 ROD_04701(geranyltranstransferase) ENC_23390(farnesyl-diphosphate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3561(Farnesyl diphosphate synthase,geranyltranstransferase,Geranylgeranyl pyrophosphate synthase,heptaprenyl diphosphate synthase component II,Polyprenyl synthetase) b0421(geranyltranstransferase) BN373_08621(geranyltranstransferase) t2440(geranyltranstransferase) SL1344_0417(geranyltranstransferase) Cluster1776 1 1 1 1 1 1 1 ROD_04691(1-deoxyxylulose-5-phosphate synthase) ENC_23400(1-deoxy-D-xylulose-5-phosphate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3562(1-deoxy-D-xylulose-5-phosphate synthase,1-deoxy-D-xylulose-5-phosphate synthase,Transketolase, C-terminal subunit,1-deoxy-D-xylulose-5-phosphate synthase,Transketolase, pyrimidine binding domain) b0420(1-deoxyxylulose-5-phosphate synthase, thiamine-requiring, FAD-requiring) BN373_08611(1-deoxy-D-xylulose-5-phosphate synthase) t2441(1-deoxyxylulose-5-phosphate synthase) SL1344_0416(1-deoxyxylulose-5-phosphate synthase) Cluster1777 1 1 1 1 1 1 1 ROD_04681(putative aldo/keto reductase) ENC_23410(Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3563(hypothetical protein,L-glyceraldehyde 3-phosphate reductase,Predicted oxidoreductase,voltage-dependent potassium channel beta subunit,Aldo/keto reductase family) b0419(2-carboxybenzaldehyde reductase, function unknown) BN373_08601(oxidoreductase, aldo/keto reductase family) t2442(putative oxidoreductase) SL1344_0415(putative oxidoreductase) Cluster1778 1 1 1 1 1 1 1 ROD_04661(thiamine-monophosphate kinase) ENC_23420(thiamine-phosphate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3565(Thiamine-monophosphate kinase,thiamine monophosphate kinase,Hydrogenase maturation factor,thiamine-monophosphate kinase,AIR synthase related protein, N-terminal domain) b0417(thiamin-monophosphate kinase) BN373_08581(thiamine-monophosphate kinase) t2444(thiamine-monophosphate kinase) SL1344_0413(thiamine-monophosphate kinase) Cluster1779 1 1 1 1 1 1 1 ROD_04641(6,7-dimethyl-8-ribityllumazine synthase (riboflavin synthase beta chain)) ENC_23440(6,7-dimethyl-8-ribityllumazine synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3567(6,7-dimethyl-8-ribityllumazine synthase,6,7-dimethyl-8-ribityllumazine synthase,6,7-dimethyl-8-ribityllumazine synthase,6,7-dimethyl-8-ribityllumazine synthase) b0415(riboflavin synthase beta chain) BN373_08561(6,7-dimethyl-8-ribityllumazine synthase) t2446(6,7-dimethyl-8-ribityllumazine synthase) SL1344_0411(6,7-dimethyl-8-ribityllumazine synthase (riboflavin synthase beta chain)) Cluster1780 1 1 1 1 1 1 1 ROD_04631(riboflavin biosynthesis protein) ENC_23450(diaminohydroxyphosphoribosylaminopyrimidine deaminase /5-amino-6-(5-phosphoribosylamino)uracil reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3568(Riboflavin biosynthesis protein RibD,bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase,Pyrimidine deaminase,riboflavin biosynthesis protein RibD,RibD C-terminal domain) b0414(fused diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase) BN373_08551(riboflavin biosynthesis protein RibD) t2447(riboflavin biosynthesis protein RibD) SL1344_0410(riboflavin biosynthesis protein RibD) Cluster1781 1 1 1 1 1 1 1 ROD_04611(putative lipoprotein) ENC_23470(Protein of unknown function (DUF3251).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3570(Uncharacterized lipoprotein yajI precursor,hypothetical protein,Protein of unknown function (DUF3251)) b0412(predicted lipoprotein) BN373_08531(putative lipoprotein) t2449(putative lipoprotein) SL1344_0408(putative lipoprotein) Cluster1782 1 1 1 1 1 1 1 ROD_04601(nucleoside-specific channel-forming protein) ENC_23480(Nucleoside-binding outer membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3571(Nucleoside-specific channel-forming protein tsx precursor,nucleoside-specific channel-forming protein Tsx,Nucleoside-specific channel-forming protein, Tsx) b0411(nucleoside channel, receptor of phage T6 and colicin K) BN373_08521(nucleoside-specific channel-forming protein) t2450(nucleoside-specific channel-forming protein tsx precursor) SL1344_0407(nucleoside-specific channel-forming protein tsx precursor) Cluster1783 1 1 1 1 1 1 1 ROD_04561(protein-export protein) ENC_23520(protein-export membrane protein SecD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3574(hypothetical protein,preprotein translocase subunit SecD,Predicted exporter,protein-export membrane protein SecD,Protein export membrane protein) b0408(SecYEG protein translocase auxillary subunit) BN373_08481(protein-export membrane protein SecD) t2456(export membrane protein SecD) SL1344_0402(protein-export membrane protein SecD) Cluster1784 1 1 1 1 1 1 1 ROD_04551(putative preprotein translocase subunit) ENC_23530(protein translocase subunit yajC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3575(hypothetical protein,preprotein translocase subunit YajC,preprotein translocase, YajC subunit,Preprotein translocase subunit) b0407(SecYEG protein translocase auxillary subunit) BN373_08471(preprotein translocase, YajC subunit) t2457(putative membrane protein) SL1344_0401(putative membrane protein) Cluster1785 1 1 1 1 1 1 1 ROD_04541(queuine tRNA-ribosyltransferase) ENC_23540(tRNA-guanine transglycosylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3576(Queuine tRNA-ribosyltransferase,queuine tRNA-ribosyltransferase,queuine tRNA-ribosyltransferase,Queuine tRNA-ribosyltransferase) b0406(tRNA-guanine transglycosylase) BN373_08461(queuine tRNA-ribosyltransferase) t2458(queuine tRNA-ribosyltransferase) SL1344_0400(queuine tRNA-ribosyltransferase; tRNA-guanine transglycosylase) Cluster1786 1 1 1 1 1 1 1 ROD_04531(S-adenosylmethionine:tRNA ribosyltransferase-isomerase) ENC_23550(S-adenosylmethionine:tRNA ribosyltransferase-isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3577(S-adenosylmethionine:tRNA ribosyltransferase-isomerase,S-adenosylmethionine:tRNA ribosyltransferase-isomerase,S-adenosylmethionine:tRNA-ribo syltransferase-isomerase (queuine synthetase),S-adenosylmethionine:tRNA ribosyltransferase-isomerase,Queuosine biosynthesis protein) b0405(S-adenosylmethionine:tRNA ribosyltransferase-isomerase) BN373_08451(S-adenosylmethionine:tRNA ribosyltransferase-isomerase) t2459(S-adenosylmethionine:tRNA ribosyltransferase-isomerase) SL1344_0399(S-adenosylmethionine:tRNA ribosyltransferase-isomerase) Cluster1787 1 1 1 1 1 1 1 ROD_04521(acyl carrier protein phosphodiesterase) ENC_23560(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3578(acyl carrier protein phosphodiesterase,Uncharacterized protein conserved in bacteria,Protein of unknown function, DUF479) b0404(conserved protein) BN373_08441(acyl carrier protein phosphodiesterase) t2460(conserved hypothetical protein) SL1344_0398(conserved hypothetical protein) Cluster1788 1 1 1 1 1 1 1 ROD_38781(putative sugar kinase) ENC_00310(Sugar kinases, ribokinase family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4627(Ribokinase,ribokinase,Uncharacterized protein conserved in bacteria,ribokinase,pfkB family carbohydrate kinase) b3883(predicted sugar kinase) BN373_08381(kinase, pfkB family) t3597(putative sugar kinase) SL1344_3970(putative sugar kinase) Cluster1789 1 1 1 1 1 1 1 ROD_04481(maltodextrin glucosidase) ENC_23600(Glycosidases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3579(Neopullulanase 1 precursor,maltodextrin glucosidase,Maltooligosyl trehalose synthase,trehalose synthase,Alpha amylase, catalytic domain) b0403(maltodextrin glucosidase) BN373_08321(maltodextrin glucosidase) t2462(maltodextrin glucosidase) SL1344_0396(maltodextrin glucosidase) Cluster1790 1 1 1 1 1 1 1 ROD_04451(branched chain amino acid transport system II carrier protein) ENC_23620(branched-chain amino acid uptake carrier) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3581(LIV-II,branched-chain amino acid transport system 2 carrier protein BrnQ,Uncharacterized membrane protein,branched-chain amino acid transport system II carrier protein,Branched-chain amino acid transport protein) b0401(Branched-chain amino acid transport system 2 carrier protein; LIV-II transport system for Ile, Leu, and Val) BN373_08301(branched-chain amino acid transport system II carrier protein) t2465(branched chain amino acid transport system II carrier protein) SL1344_0394(branched chain amino acid transport system II carrier protein) Cluster1791 1 1 1 1 1 1 1 ROD_04431(phosphate regulon two-component system, response regulator) ENC_23640(phosphate regulon transcriptional regulatory protein PhoB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3583(Phosphate regulon transcriptional regulatory protein phoB,transcriptional regulator PhoB,Response regulator containing a CheY-like receiver domain and an HD-GYP domain,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain) b0399(DNA-binding response regulator in two-component regulatory system with PhoR (or CreC)) BN373_08281(phosphate regulon transcriptional regulatory protein PhoB) t2467(phosphate regulon transcriptional regulatory protein PhoB) SL1344_0392(phosphate regulon transcriptional regulatory protein PhoB) Cluster1792 1 1 1 1 1 1 1 ROD_04421(exonuclease SbcD) ENC_23660(Exodeoxyribonuclease I subunit D) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3584(Nuclease sbcCD subunit D,exonuclease subunit SbcD,Uncharacterized protein conserved in bacteria,exonuclease SbcCD, D subunit,Type 5 capsule protein repressor C-terminal domain) b0398(exonuclease, dsDNA, ATP-dependent) BN373_08271(nuclease SbcCD, D subunit) t2468(exonuclease SbcD) SL1344_0391(exonuclease SbcD) Cluster1793 1 1 1 1 1 1 1 ROD_04411(exonuclease SbcC) ENC_23670(exonuclease SbcC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3585(Nuclease sbcCD subunit C,exonuclease subunit SbcC,ATPase involved in DNA repair,exonuclease SbcC) b0397(exonuclease, dsDNA, ATP-dependent) BN373_08261(nuclease SbcCD, C subunit) t2469(exonuclease SbcC) SL1344_0390(exonuclease SbcC) Cluster1794 1 1 1 1 1 1 1 ROD_04361(conserved hypothetical protein) ENC_23700(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3590(hypothetical protein,hypothetical protein,Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF1255)) b0391(conserved protein, UPF0345 family) BN373_08231(conserved hypothetical protein) t2473(conserved hypothetical protein) SL1344_0386(conserved hypothetical protein) Cluster1795 1 1 1 1 1 1 1 ROD_04331(conserved hypothetical protein) ENC_23720(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3592(hypothetical protein,hypothetical protein) b0389(predicted protein) BN373_08211(conserved hypothetical protein) t2475(conserved hypothetical protein) SL1344_0384(conserved hypothetical protein) Cluster1796 1 1 1 1 1 1 1 ROD_04311(conserved hypothetical protein) ENC_23740(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3594(hypothetical protein,hypothetical protein,Uncharacterized BCR, YaiI/YqxD family COG1671) b0387(conserved protein, UPF0178 family, downregulated by beryllium) BN373_08181(conserved hypothetical protein) t2477(conserved hypothetical protein) SL1344_0382(conserved hypothetical protein) Cluster1797 1 1 1 1 1 1 1 ROD_04301(pyrroline-5-carboxylate reductase) ENC_23750(pyrroline-5-carboxylate reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3595(Pyrroline-5-carboxylate reductase,pyrroline-5-carboxylate reductase,Pyrroline-5-carboxylate reductase,pyrroline-5-carboxylate reductase,NADP oxidoreductase coenzyme F420-dependent) b0386(pyrroline-5-carboxylate reductase, NAD(P)-binding) BN373_08171(pyrroline-5-carboxylate reductase) t2478(pyrroline-5-carboxylate reductase) SL1344_0381(pyrroline-5-carboxylate reductase) Cluster1798 1 1 1 1 1 1 1 ROD_04281(phosphate starvation-inducible protein) ENC_23770(psiF repeat.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3597(Phosphate starvation-inducible protein psiF precursor,hypothetical protein,psiF repeat) b0384(conserved protein, PsiF family, pho regulon) BN373_08161(phosphate starvation-inducible protein PsiF) t2480(phosphate starvation-inducible protein PsiF) SL1344_0379(phosphate starvation-inducible protein PsiF) Cluster1799 1 1 1 1 1 1 1 ROD_04261(conserved hypothetical protein) ENC_23780(Sigma-S stabilisation anti-adaptor protein.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3599(Anti-adapter protein iraP,anti-RssB factor,Sigma-S stabilisation anti-adaptor protein) b0382(anti-RssB factor, RpoS stabilzer during Pi starvation; anti-adapter protein) BN373_08141(conserved hypothetical protein) t2481(conserved hypothetical protein) SL1344_0378(conserved hypothetical protein) Cluster1800 1 1 1 1 1 1 1 ROD_04211(putative membrane protein) ENC_23830(Protein of unknown function (DUF2754).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3601(Protein of unknown function (DUF2754)) b0380(predicted inner membrane protein, DUF2754 family) BN373_08101(conserved hypothetical protein) t2485(putative membrane protein) SL1344_0374(putative membrane protein) Cluster1801 1 1 1 1 1 1 1 ROD_04201(putative membrane protein) ENC_23840(Protein of unknown function (DUF2755).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3602(Inner membrane protein yaiY,Protein of unknown function (DUF2755)) b0379(inner membrane protein, DUF2755 family) BN373_08091(putative membrane protein) t2486(putative membrane protein) SL1344_0373(putative membrane protein) Cluster1802 1 1 1 1 1 1 1 ROD_04191(putative lipoprotein) ENC_23850(Protein of unknown function (DUF1615).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3603(Protein of unknown function (DUF1615)) b0378(probable lipoprotein required for swarming phenotype) BN373_08081(putative lipoprotein) t2487(putative lipoprotein) SL1344_0372(putative lipoprotein) Cluster1803 1 1 1 1 1 1 1 ROD_04181(putative microcin B17 uptake protein) ENC_23860(ABC-type long-chain fatty acid transport system, fused permease and ATPase components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3604(hypothetical protein,microcin B17 transporter,SbmA/BacA-like family) b0377(microcin B17 transporter) BN373_08071(protein SbmA) t2488(probable ABC-transporter inner membrane protein SbmA) SL1344_0371(probable ABC-transporter inner membrane protein SbmA) Cluster1804 1 1 1 1 1 1 1 ROD_04141(delta-aminolevulinic acid dehydratase) ENC_23910(porphobilinogen synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3609(Delta-aminolevulinic acid dehydratase,delta-aminolevulinic acid dehydratase,Delta-aminolevulinic acid dehydratase,Delta-aminolevulinic acid dehydratase) b0369(5-aminolevulinate dehydratase (porphobilinogen synthase)) BN373_08041(delta-aminolevulinic acid dehydratase) t2492(delta-aminolevulinic acid dehydratase) SL1344_0367(delta-aminolevulinic acid dehydratase) Cluster1805 1 1 1 1 1 1 1 ROD_03361(outer membrane pore protein E) ENC_24530(Outer membrane protein (porin)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3700(Outer membrane pore protein E precursor,outer membrane phosphoporin protein E,Outer membrane protein (porin),Gram-negative porin) b0241(outer membrane phosphoporin protein E) BN373_07701(outer membrane pore protein E) t2530(outer membrane pore protein E precursor) SL1344_0316(outer membrane pore protein E precursor) Cluster1806 1 1 1 1 1 1 1 ROD_03371(glutamate 5-kinase) ENC_24520(glutamate 5-kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3699(Glutamate 5-kinase,gamma-glutamyl kinase,Gamma-glutamyl phosphate reductase,glutamate 5-kinase,Amino acid kinase family) b0242(gamma-glutamate kinase) BN373_07691(glutamate 5-kinase) t2529(glutamate 5-kinase) SL1344_0317(glutamate 5-kinase) Cluster1807 1 1 1 1 1 1 1 ROD_03381(gamma-glutamyl phosphate reductase) ENC_24510(glutamate-5-semialdehyde dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3698(Gamma-glutamyl phosphate reductase,gamma-glutamyl phosphate reductase,Gamma-glutamyl phosphate reductase,glutamate-5-semialdehyde dehydrogenase,Aldehyde dehydrogenase family) b0243(gamma-glutamylphosphate reductase) BN373_07681(gamma-glutamyl phosphate reductase) t2528(gamma-glutamyl phosphate reductase) SL1344_0318(gamma-glutamyl phosphate reductase) Cluster1808 1 1 1 1 1 1 1 ROD_03351(sigma factor-binding protein crl (curlin genes transcriptional activator)) ENC_24550(Transcriptional regulator Crl.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3701(Curlin genes transcriptional activatory protein,DNA-binding transcriptional regulator Crl,Transcriptional regulator Crl) b0240(sigma factor-binding protein, stimulates RNA polymerase holoenzyme formation) BN373_07361(sigma factor-binding protein Crl) t2531(curlin genes transcriptional activator) SL1344_0315(curlin genes transcriptional activator) Cluster1809 1 1 1 1 1 1 1 ROD_03341(esterase) ENC_24560(Dienelactone hydrolase and related enzymes) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3702(hypothetical protein,fermentation/respiration switch protein,Alpha/beta hydrolase of unknown function (DUF1100)) b0239(fermentation-respiration switch protein; PTS Enzyme IIA(Glc)-binding protein; pNP-butyrate esterase activity) BN373_07351(fermentation-respiration switch protein) t2532(conserved hypothetical protein) SL1344_0314(conserved hypothetical protein) Cluster1810 1 1 1 1 1 1 1 ROD_03331(xanthine phosphoribosyltransferase) ENC_24570(Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3703(Xanthine phosphoribosyltransferase,xanthine-guanine phosphoribosyltransferase,hypoxanthine phosphoribosyltransferase,Phosphoribosyl transferase domain) b0238(guanine-hypoxanthine phosphoribosyltransferase) BN373_07341(xanthine phosphoribosyltransferase) t2533(xanthine-guanine phosphoribosyltransferase) SL1344_0313(xanthine-guanine phosphoribosyltransferase) Cluster1811 1 1 1 1 1 1 1 ROD_03311(DNA polymerase IV) ENC_24590(Nucleotidyltransferase/DNA polymerase involved in DNA repair) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3708(DNA polymerase IV,DNA polymerase IV,Nucleotidyltransferase/DNA polymerase involved in DNA repair,impB/mucB/samB family) b0231(DNA polymerase IV) BN373_07311(DNA polymerase IV) t2537(hypothetical protein DinP) SL1344_0309(DNA polymerase IV) Cluster1812 1 1 1 1 1 1 1 ROD_02251(putative lipoprotein) ENC_24670(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3757(Uncharacterized protein conserved in bacteria,L,D-transpeptidase catalytic domain) b0224(conserved protein) BN373_07221(conserved hypothetical protein) t2538(putative exported protein) SL1344_0308(putative exported protein) Cluster1813 1 1 1 1 1 1 1 ROD_02241(putative amidotransferase) ENC_24680(Predicted glutamine amidotransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3758(Predicted glutamine amidotransferase,conserved hypothetical protein,Glutamine amidotransferases class-II) b0223(predicted amidotransfease) BN373_07211(glutamine amidotransferase, class II) t2539(conserved hypothetical protein) SL1344_0307(conserved hypothetical protein) Cluster1814 1 1 1 1 1 1 1 ROD_02231(phosphoheptose isomerase) ENC_24690(phosphoheptose isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3759(Phosphoheptose isomerase,phosphoheptose isomerase,Uncharacterized protein containing SIS (Sugar ISomerase) phosphosugar binding domain,phosphoheptose isomerase,SIS domain) b0222(D-sedoheptulose 7-phosphate isomerase) BN373_07201(phosphoheptose isomerase) t2540(phosphoheptose isomerase) SL1344_0306(Phosphoheptose isomerase) Cluster1815 1 1 1 1 1 1 1 ROD_02221(acyl-CoA dehydrogenase) ENC_24700(Acyl-CoA dehydrogenases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3760(Acyl-CoA dehydrogenase fadE12,acyl-CoA dehydrogenase,Rubredoxin,cyclohexanecarboxyl-CoA dehydrogenase,Domain of unknown function (DUF1974)) b0221(acyl coenzyme A dehydrogenase) BN373_07191(acyl-coenzyme A dehydrogenase) t2541(possible acyl-CoA dehydrogenase) SL1344_0305(possible acyl-CoA dehydrogenase) Cluster1816 1 1 1 1 1 1 1 ROD_02211(putative carbon-nitrogen hydrolase) ENC_24710(Predicted amidohydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3762((R)-stereoselective amidase,C-N hydrolase family amidase,N-carbamoylputrescine amidase,Carbon-nitrogen hydrolase) b0219(predicted C-N hydrolase family amidase, NAD(P)-binding) BN373_07181(hydrolase, carbon-nitrogen family) t2542(possible hydrolase) SL1344_0304(possible hydrolase) Cluster1817 1 1 1 1 1 1 1 ROD_02201(DNA polymerase III epsilon subunit) ENC_24790(DNA polymerase III, epsilon subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3764(DNA polymerase III subunit epsilon,DNA polymerase III subunit epsilon,exonuclease, DNA polymerase III, epsilon subunit family,Exonuclease) b0215(DNA polymerase III epsilon subunit) BN373_07151(DNA polymerase III, epsilon subunit) t2601(DNA polymerase III epsilon subunit) SL1344_0259(DNA polymerase III epsilon subunit) Cluster1818 1 1 1 1 1 1 1 ROD_02191(ribonuclease HI) ENC_24800(RNase HI) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3765(Ribonuclease HI,ribonuclease H,Predicted double-stranded RNA/RNA-DNA hybrid binding protein,RNase H) b0214(ribonuclease HI, degrades RNA of DNA-RNA hybrids) BN373_07141(ribonuclease H) t2602(ribonuclease H) SL1344_0258(ribonuclease H) Cluster1819 1 1 1 1 1 1 1 ROD_02181(conserved hypothetical protein) ENC_24810(Methylase involved in ubiquinone/menaquinone biosynthesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3766(hypothetical protein,biotin biosynthesis protein BioC,Methyltransferase domain) b0213(predicted S-adenosyl-L-methionine-dependent methyltransferase) BN373_07131(putative methyltransferase) t2603(conserved hypothetical protein) SL1344_0257(conserved hypothetical protein) Cluster1820 1 1 1 1 1 1 1 ROD_02171(probable hydroxyacylglutathione hydrolase) ENC_24820(hydroxyacylglutathione hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3767(Hydroxyacylglutathione hydrolase,hydroxyacylglutathione hydrolase,Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain,hydroxyacylglutathione hydrolase,Metallo-beta-lactamase superfamily) b0212(hydroxyacylglutathione hydrolase) BN373_07121(hydroxyacylglutathione hydrolase) t2604(probable hydroxyacylglutathione hydrolase) SL1344_0256(probable hydroxyacylglutathione hydrolase) Cluster1821 1 1 1 1 1 1 1 ROD_02151(putative methyltransferase) ENC_24840(Methylase involved in ubiquinone/menaquinone biosynthesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3769(Uncharacterized methyltransferase ycgJ,hypothetical protein,Trans-aconitate methyltransferase,ubiquinone/menaquinone biosynthesis methyltransferase,Methyltransferase domain) b0210(predicted S-adenosyl-L-methionine-dependent methyltransferase) BN373_07101(methyltransferase, UbiE/COQ5 family) t2606(putative methyltransferase) SL1344_0254(putative methyltransferase) Cluster1822 1 1 1 1 1 1 1 ROD_02141(conserved hypothetical protein) ENC_24850(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3770(hypothetical protein,Uncharacterized protein conserved in bacteria,Endonuclease/Exonuclease/phosphatase family) b0209(conserved protein) BN373_07091(endonuclease/exonuclease/phosphatase family protein) t2607(conserved hypothetical protein) SL1344_0253(hypothetical protein) Cluster1823 1 1 1 1 1 1 1 ROD_02131(LysR-family transcriptional regulator) ENC_24870(transcriptional regulator, LysR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3771(D-malate degradation protein R,DNA-binding transcriptional activator GcvA,ABC-type uncharacterized transport system, periplasmic component,putative choline sulfate-utilization transcription factor,LysR substrate binding domain) b0208(predicted DNA-binding transcriptional regulator) BN373_07071(transcriptional regulator, LysR family) t2609(hypothetical transcriptional regulator) SL1344_0251(hypothetical transcriptional regulator) Cluster1824 1 1 1 1 1 1 1 ROD_02121(2,5-diketo-D-gluconic acid reductase A) ENC_24880(Aldo/keto reductases, related to diketogulonate reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3772(2,5-diketo-D-gluconic acid reductase B,2,5-diketo-D-gluconate reductase B,Predicted oxidoreductase,voltage-dependent potassium channel beta subunit,Aldo/keto reductase family) b0207(2,5-diketo-D-gluconate reductase B) BN373_07061(2,5-didehydrogluconate reductase B) t2610(hypothetical oxidoreductase) SL1344_0250(hypothetical oxidoreductase) Cluster1825 1 1 1 1 1 1 1 ROD_02091(D-methionine ABC transporter, ATP-binding protein) ENC_47210(D-methionine ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3779(Methionine import ATP-binding protein MetN,DL-methionine transporter ATP-binding subunit,ABC-type proline/glycine betaine transport system, ATPase component,D-methionine ABC transporter, ATP-binding protein,ABC transporter) b0199(DL-methionine transporter subunit) BN373_07041(D-methionine ABC transporter, ATP-binding protein) t0250(putative ABC transporter ATP-binding protein) SL1344_0248(putative ABC transporter ATP-binding protein) Cluster1826 1 1 1 1 1 1 1 ROD_02081(D-methionine ABC transporter, permease protein) ENC_47200(ABC-type metal ion transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3780(D-methionine transport system permease protein metI,DL-methionine transporter permease subunit,ABC-type phosphate/phosphonate transport system, permease component,phosphonate ABC transporter, permease protein PhnE,Binding-protein-dependent transport system inner membrane component) b0198(DL-methionine transporter subunit) BN373_07031(D-methionine ABC transporter, permease protein) t0249(putative ABC transporter permease protein) SL1344_0247(putative ABC transporter permease protein) Cluster1827 1 1 1 1 1 1 1 ROD_02071(D-methionine ABC transporter, substrate-binding lipoprotein) ENC_47190(lipoprotein, YaeC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3781(D-methionine-binding lipoprotein metQ precursor,DL-methionine transporter substrate-binding subunit,ABC-type taurine transport system, periplasmic component,lipoprotein, YaeC family,NLPA lipoprotein) b0197(DL-methionine transporter subunit) BN373_07021(D-methionine ABC transporter, periplasmic D-methionine-binding lipoprotein) t0248(putative lipoprotein precursor) SL1344_0246(putative lipoprotein precursor) Cluster1828 1 1 1 1 1 1 1 ROD_02061(RcsF, phosphorelay glucose and zinc sensor) ENC_47180(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3782(hypothetical protein,outer membrane lipoprotein) b0196(predicted outer membrane protein, signal) BN373_07011(exopolysaccharide synthesis regulator RcsF) t0247(rcsF protein) SL1344_0245(RcsF protein) Cluster1829 1 1 1 1 1 1 1 ROD_02051(conserved hypothetical protein) ENC_47170(conserved hypothetical protein TIGR00104) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3783(hypothetical protein,putative methyltransferase, YaeB/AF_0241 family,Uncharacterised protein family UPF0066) b0195(conserved protein, UPF0066 family) BN373_07001(conserved hypothetical protein TIGR00104) t0246(conserved hypothetical protein) SL1344_0244(conserved hypothetical protein) Cluster1830 1 1 1 1 1 1 1 ROD_02041(prolyl-tRNA synthetase) ENC_47160(prolyl-tRNA synthetase, family II) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3784(Proline--tRNA ligase,prolyl-tRNA synthetase,Prolyl-tRNA synthetase,proline--tRNA ligase,tRNA synthetase class II core domain (G, H, P, S and T)) b0194(prolyl-tRNA synthetase) BN373_06991(prolyl-tRNA synthetase) t0245(prolyl-tRNA synthetase) SL1344_0243(prolyl-tRNA synthetase) Cluster1831 1 1 1 1 1 1 1 ROD_01991(putative peptidyl-tRNA hydrolase) ENC_47140(Protein chain release factor B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3787(Peptidyl-tRNA hydrolase YaeJ,hypothetical protein,putative peptide chain release factor H,RF-1 domain) b0191(petidyl-tRNA hydrolase, ribosome-attached; stalled ribosome rescue factor) BN373_06961(putative peptidyl-tRNA hydrolase) t0242(putative release factor) SL1344_0241(putative release factor) Cluster1832 1 1 1 1 1 1 1 ROD_01981(conserved hypothetical protein) ENC_47130(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3788(hypothetical protein,Uncharacterized protein conserved in bacteria,YaeQ protein) b0190(conserved protein) BN373_06951(conserved hypothetical protein) t0241(conserved hypothetical protein) SL1344_0240(conserved hypothetical protein) Cluster1833 1 1 1 1 1 1 1 ROD_01971(Rho-binding antiterminator) ENC_47120(Transcriptional antiterminator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3790(hypothetical protein,Rho-binding antiterminator,Modulator of Rho-dependent transcription termination (ROF)) b0189(modulator of Rho-dependent transcription termination) BN373_06941(rof protein) t0239(ROF protein) SL1344_0238(ROF protein) Cluster1834 1 1 1 1 1 1 1 ROD_01961(tRNA(Ile)-lysidine synthase) ENC_47110(tRNA(Ile)-lysidine synthetase, N-terminal domain/tRNA(Ile)-lysidine synthetase, C-terminal domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3791(tRNA(Ile)-lysidine synthase,tRNA(Ile)-lysidine synthetase,Predicted ATPase of the PP-loop superfamily implicated in cell cycle control,tRNA(Ile)-lysidine synthetase,PP-loop family) b0188(tRNA(Ile)-lysidine synthetase) BN373_06931(tRNA(Ile)-lysidine synthase) t0238(cell cycle protein MesJ) SL1344_0237(cell cycle protein MesJ) Cluster1835 1 1 1 1 1 1 1 ROD_01951(conserved hypothetical protein) ENC_47100(Lactoylglutathione lyase and related lyases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3792(putative lyase,methylmalonyl-CoA epimerase,Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily) b0187(predicted lyase) BN373_06921(glyoxalase family protein) t0237(conserved hypothetical protein) SL1344_0236(conserved hypothetical protein) Cluster1836 1 1 1 1 1 1 1 ROD_01881(acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha) ENC_47080(acetyl-CoA carboxylase carboxyltransferase subunit alpha) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3794(Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha,acetyl-CoA carboxylase carboxyltransferase subunit alpha,Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta),acetyl-CoA carboxylase, carboxyl transferase, alpha subunit,Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit) b0185(acetyl-CoA carboxylase, carboxytransferase, alpha subunit) BN373_06901(acetyl-CoA carboxylase, carboxyl transferase, alpha subunit) t0233(acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha) SL1344_0233(acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha) Cluster1837 1 1 1 1 1 1 1 ROD_01871(DNA polymerase III alpha subunit) ENC_47070(DNA polymerase III, alpha subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3795(DNA polymerase III subunit alpha,DNA polymerase III subunit alpha,DNA polymerase III, alpha subunit,Bacterial DNA polymerase III alpha subunit) b0184(DNA polymerase III alpha subunit) BN373_06891(DNA polymerase III, alpha subunit) t0232(DNA polymerase III, alpha chain) SL1344_0232(DNA polymerase III, alpha chain) Cluster1838 1 1 1 1 1 1 1 ROD_01861(ribonuclease HII) ENC_47060(RNase HII) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3796(Ribonuclease HII,ribonuclease HII,ribonuclease HII,Ribonuclease HII) b0183(ribonuclease HII, degrades RNA of DNA-RNA hybrids) BN373_06881(ribonuclease HII) t0231(ribonuclease HII) SL1344_0231(ribonuclease HII) Cluster1839 1 1 1 1 1 1 1 ROD_01851(lipid-A-disaccharide synthase) ENC_47050(lipid-A-disaccharide synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3797(Lipid-A-disaccharide synthase,lipid-A-disaccharide synthase,Predicted membrane protein,lipid-A-disaccharide synthase,Lipid-A-disaccharide synthetase) b0182(tetraacyldisaccharide-1-P synthase) BN373_06871(lipid-A-disaccharide synthase) t0230(lipid-A-disaccharide synthase) SL1344_0230(Lipid-A-disaccharide synthase) Cluster1840 1 1 1 1 1 1 1 ROD_01821(UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase) ENC_47020(UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3800(UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase,UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase,Ribosomal protein S2,UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase,Bacterial transferase hexapeptide (six repeats)) b0179(UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase) BN373_06841(UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase) t0227(UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase) SL1344_0227(UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase) Cluster1841 1 1 1 1 1 1 1 ROD_01811(chaperone protein) ENC_47010(Outer membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3801(Seventeen kilodalton protein,periplasmic chaperone,Outer membrane protein,Outer membrane protein (OmpH-like)) b0178(periplasmic chaperone) BN373_06831(chaperone protein Skp) t0226(outer membrane protein OmpH precursor) SL1344_0226(outer membrane protein OmpH precursor) Cluster1842 1 1 1 1 1 1 1 ROD_01791(protease) ENC_46990(RIP metalloprotease RseP) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3803(Regulator of sigma E protease,zinc metallopeptidase RseP,Translation elongation factor Ts,RIP metalloprotease RseP,Peptidase family M50) b0176(inner membrane zinc RIP metalloprotease; RpoE activator, by degrading RseA) BN373_06811(RIP metalloprotease RseP) t0224(putative membrane protein) SL1344_0224(putative membrane protein) Cluster1843 1 1 1 1 1 1 1 ROD_01771(undecaprenyl pyrophosphate synthetase) ENC_46970(Undecaprenyl pyrophosphate synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3806(Undecaprenyl pyrophosphate synthase,undecaprenyl pyrophosphate synthase,Undecaprenyl pyrophosphate synthase,di-trans,poly-cis-decaprenylcistransferase,Putativ e undecaprenyl diphosphate synthase) b0174(undecaprenyl pyrophosphate synthase) BN373_06791(di-trans,poly-cis-decaprenylcistransferase) t0222(undecaprenyl pyrophosphate synthetase) SL1344_0222(undecaprenyl pyrophosphate synthetase) Cluster1844 1 1 1 1 1 1 1 ROD_01761(1-deoxy-D-xylulose 5-phosphate reductoisomerase) ENC_46960(1-deoxy-D-xylulose 5-phosphate reductoisomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3807(1-deoxy-D-xylulose 5-phosphate reductoisomerase,1-deoxy-D-xylulose 5-phosphate reductoisomerase,Translation elongation factor Ts,1-deoxy-D-xylulose 5-phosphate reductoisomerase,1-deoxy-D-xylulose 5-phosphate reductoisomerase) b0173(1-deoxy-D-xylulose 5-phosphate reductoisomerase) BN373_06781(1-deoxy-D-xylulose 5-phosphate reductoisomerase) t0221(1-deoxy-D-xylulose 5-phosphate reductoisomerase) SL1344_0221(1-deoxy-D-xylulose 5-phosphate reductoisomerase) Cluster1845 1 1 1 1 1 1 1 ROD_01741(uridylate kinase) ENC_46940(uridylate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3809(Uridylate kinase,uridylate kinase,Uridylate kinase,UMP kinase,Amino acid kinase family) b0171(uridylate kinase) BN373_06761(UMP kinase) t0219(uridine 5'-monophosphate kinase) SL1344_0219(Uridylate kinase) Cluster1846 1 1 1 1 1 1 1 ROD_01731(elongation factor Ts) ENC_46930(translation elongation factor Ts (EF-Ts)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3810(Elongation factor Ts,elongation factor Ts,Translation elongation factor Ts,translation elongation factor Ts,Elongation factor TS) b0170(protein chain elongation factor EF-Ts) BN373_06751(translation elongation factor Ts) t0218(elongation factor Ts) SL1344_0218(Elongation factor Ts) Cluster1847 1 1 1 1 1 1 1 ROD_01721(30S ribosomal protein S2) ENC_46920(SSU ribosomal protein S2P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3811(30S ribosomal protein S2,30S ribosomal protein S2,Ribosomal protein S2,ribosomal protein S2,Ribosomal protein S2) b0169(30S ribosomal subunit protein S2) BN373_06741(ribosomal protein S2) t0217(30S ribosomal protein S2) SL1344_0217(30S ribosomal protein S2) Cluster1848 1 1 1 1 1 1 1 ROD_01711(methionine aminopeptidase) ENC_46910(methionine aminopeptidase, type I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3813(Methionine aminopeptidase,methionine aminopeptidase,Xaa-Pro aminopeptidase,methionine aminopeptidase, type I,Metallopeptidase family M24) b0168(methionine aminopeptidase) BN373_06731(methionine aminopeptidase, type I) t0216(methionine aminopeptidase) SL1344_0216(methionine aminopeptidase) Cluster1849 1 1 1 1 1 1 1 ROD_01701([protein-PII] uridylyltransferase) ENC_46900(UTP:GlnB (protein PII) uridylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3814(PII uridylyl-transferase,UTP:GlnB (protein PII) uridylyltransferase,protein-P-II uridylyltransferase,GlnD PII-uridylyltransferase) b0167(uridylyltransferase) BN373_06721(protein-P-II uridylyltransferase) t0215([protein-PII] uridylyltransferase) SL1344_0215([Protein-PII] uridylyltransferase) Cluster1850 1 1 1 1 1 1 1 ROD_01691(2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase) ENC_46870(2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3815(2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase,2,3,4,5-tetrahydropyridine-2,6-carbox ylate N-succinyltransferase,Tetrahydrodipicolinate N-succinyltransferase,2,3,4,5-tetrahydropyridine-2,6-dicarb oxylate N-succinyltransferase,Bacterial transferase hexapeptide (six repeats)) b0166(2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase) BN373_06701(2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase) t0214(2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase) SL1344_0214(2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase) Cluster1851 1 1 1 1 1 1 1 ROD_01681(conserved hypothetical protein) ENC_46860(Protein of unknown function (DUF3461).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3816(hypothetical protein,Protein of unknown function (DUF3461)) b0163(conserved protein, UPF0325 family) BN373_06691(conserved hypothetical protein) t0212(conserved hypothetical protein) SL1344_0212(conserved hypothetical protein) Cluster1852 1 1 1 1 1 1 1 ROD_01651(protease Do precursor) ENC_46830(peptidase Do . Serine peptidase. MEROPS family S01B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3818(Periplasmic serine endoprotease DegP precursor,serine endoprotease,Predicted secreted protein containing a PDZ domain,peptidase Do,PDZ domain (Also known as DHR or GLGF)) b0161(serine endoprotease (protease Do), membrane-associated) BN373_06671(protease Do) t0210(protease DO precursor; heat shock protein HtrA) SL1344_0210(protease DO precursor; heat shock protein HtrA) Cluster1853 1 1 1 1 1 1 1 ROD_01641(deoxyguanosinetriphosphate triphosphohydrolase) ENC_46820(deoxyguanosinetriphosphate triphosphohydrolase, putative) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3819(Deoxyguanosinetriphosphate triphosphohydrolase,deoxyguanosinetriphosphate triphosphohydrolase,putative dGTPase,HD domain) b0160(deoxyguanosine triphosphate triphosphohydrolase) BN373_06661(deoxyguanosinetriphosphate triphosphohydrolase) t0209(deoxyguanosinetriphosphate triphosphohydrolase) SL1344_0209(Deoxyguanosinetriphosphate triphosphohydrolase) Cluster1854 1 1 1 1 1 1 1 ROD_01631(MTA/SAH nucleosidase (5'-methylthioadenosine nucleosidase)) ENC_46810(methylthioadenosine nucleosidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3820(5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase,5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase,MTA/SAH nucleosidase,Phosphorylase superfamily) b0159(5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase) BN373_06651(MTA/SAH nucleosidase) t0208(MTA/SAH nucleosidase) SL1344_0208(MTA/SAH nucleosidase) Cluster1855 1 1 1 1 1 1 1 ROD_01611(putative membrane protein) ENC_46780(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3822(hypothetical protein,hypothetical protein,Predicted membrane protein,UPF0126 domain) b0157(inner membrane protein, UPF0126 family) BN373_06631(putative membrane protein) t0206(putative membrane protein) SL1344_0206(putative membrane protein) Cluster1856 1 1 1 1 1 1 1 ROD_01601(conserved hypothetical protein) ENC_46770(Iron-sulfur cluster assembly accessory protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3823(Iron-sulfur cluster insertion protein erpA,iron-sulfur cluster insertion protein ErpA,iron-sulfur cluster assembly accessory protein,Iron-sulphur cluster biosynthesis) b0156(iron-sulfur cluster insertion protein) BN373_06621(iron-sulfur cluster assembly accessory protein) t0205(conserved hypothetical protein) SL1344_0205(conserved hypothetical protein) Cluster1857 1 1 1 1 1 1 1 ROD_01591(H(+)/Cl(-) exchange transporter) ENC_46760(Chloride channel protein EriC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3824(ClC-ec1,chloride channel protein,Voltage gated chloride channel) b0155(chloride channel, voltage-gated) BN373_06611(H(+)/Cl(-) exchange transporter clcA) t0204(putative membrane protein) SL1344_0204(putative membrane protein) Cluster1858 1 1 1 1 1 1 1 ROD_01581(glutamate-1-semialdehyde 2,1-aminomutase) ENC_46750(glutamate-1-semialdehyde 2,1-aminomutase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3825(Glutamate-1-semialdehyde 2,1-aminomutase,glutamate-1-semialdehyde aminotransferase,Glutamate-1-semialdehyde aminotransferase,glutamate-1-semialdehyde-2,1-aminomutase,A minotransferase class-III) b0154(glutamate-1-semialdehyde aminotransferase (aminomutase)) BN373_06601(glutamate-1-semialdehyde-2,1-aminomutase) t0203(glutamate-1-semialdehyde 2,1-aminomutase) SL1344_0203(Glutamate-1-semialdehyde 2,1-aminomutase) Cluster1859 1 1 1 1 1 1 1 ROD_01571(ferrichrome transport system permease protein) ENC_46740(ABC-type Fe3+-siderophore transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3826(Iron(III)-hydroxamate import system permease protein fhuB,iron-hydroxamate transporter permease subunit,ABC-type Fe3+-siderophore transport system, permease component,proposed F420-0 ABC transporter, permease protein,FecCD transport family) b0153(fused iron-hydroxamate transporter subunits of ABC superfamily: membrane components) BN373_06591(iron-hydroxamate transporter permease subunit) t0202(ferrichrome transport protein FhuB precursor) SL1344_0195(ferrichrome transport protein FhuB precursor) Cluster1860 1 1 1 1 1 1 1 ROD_01561(ferrichrome-binding periplasmic protein) ENC_46730(ABC-type Fe3+-hydroxamate transport system, periplasmic component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3827(Iron(III)-hydroxamate-binding protein fhuD,iron-hydroxamate transporter substrate-binding subunit,ABC-type Fe3+-citrate transport system, periplasmic component,Periplasmic binding protein) b0152(iron-hydroxamate transporter subunit) BN373_06581(unknown) t0201(ferrichrome-binding periplasmic protein precursor) SL1344_0194(ferrichrome-binding periplasmic protein precursor) Cluster1861 1 1 1 1 1 1 1 ROD_01551(ferrichrome transport ATP-binding protein) ENC_46720(ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3828(Iron(3+)-hydroxamate import ATP-binding protein FhuC,iron-hydroxamate transporter ATP-binding subunit,ABC-type enterochelin transport system, ATPase component,proposed F420-0 ABC transporter, ATP-binding protein,ABC transporter) b0151(iron-hydroxamate transporter subunit) BN373_06571(ferrichrome ABC transporter, ATP-binding protein) t0200(ferrichrome transport ATP-binding protein FhuC) SL1344_0193(ferrichrome transport ATP-binding protein FhuC) Cluster1862 1 1 1 1 1 1 1 ROD_01531(penicillin-binding protein 1B [includes: penicillin-insensitive transglycosylase; penicillin sensitive transpeptidase]) ENC_46650(penicillin-binding protein 1B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3834(Murein polymerase,bifunctional glycosyl transferase/transpeptidase,Membrane carboxypeptidase/penicillin-binding protein,penicillin-binding protein 1B,Transglycosylase) b0149(fused glycosyl transferase and transpeptidase) BN373_06551(penicillin-binding protein 1B) t0198(penicillin-binding protein 1b) SL1344_0191(penicillin-binding protein 1b; peptidoglycan synthetase) Cluster1863 1 1 1 1 1 1 1 ROD_01511(2'-5' RNA ligase) ENC_46620(2'-5' RNA ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3836(2'-5'-RNA ligase,2'-5' RNA ligase,2'-5' RNA ligase,2',5' RNA ligase family) b0147(2'-5' RNA ligase) BN373_06371(2'-5' RNA ligase) t0196(2'-5' RNA ligase) SL1344_0189(2'-5' RNA ligase) Cluster1864 1 1 1 1 1 1 1 ROD_01501(sugar fermentation stimulation protein) ENC_46610(sugar fermentation stimulation protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3837(Sugar fermentation stimulation protein A,putative DNA-binding transcriptional regulator,sugar fermentation stimulation protein,Sugar fermentation stimulation protein) b0146(predicted DNA-binding transcriptional regulator) BN373_06361(sugar fermentation stimulation protein) t0195(sugar fermentation stimulation protein) SL1344_0188(Sugar fermentation stimulation protein homolog) Cluster1865 1 1 1 1 1 1 1 ROD_01491(dosage-dependent dnaK suppressor protein) ENC_46600(RNA polymerase-binding protein DksA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3838(DnaK suppressor protein,RNA polymerase-binding transcription factor,DnaK suppressor protein,RNA polymerase-binding protein DksA,Prokaryotic dksA/traR C4-type zinc finger) b0145(DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein) BN373_06351(RNA polymerase-binding protein DksA) t0194(dosage-dependent dnaK suppressor protein) SL1344_0187(dosage-dependent dnaK suppressor protein) Cluster1866 1 1 1 1 1 1 1 ROD_01461(2-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne pyrophosphokinase) ENC_46570(2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3841(2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase,2-amino-4-hydroxy-6-hydroxymethyldihyropt eridine pyrophosphokinase,2-amino-4-hydroxy-6-hydroxymethyldihydrop teridine diphosphokinase,7,8-dihydro-6-hydroxymethylpterin-pyrophosp hokinase (HPPK)) b0142(2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase) BN373_06321(2-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne pyrophosphokinase) t0191(2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase) SL1344_0184(2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase) Cluster1867 1 1 1 1 1 1 1 ROD_01451(3-methyl-2-oxobutanoate hydroxymethyltransferase) ENC_46560(ketopantoate hydroxymethyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3849(3-methyl-2-oxobutanoate hydroxymethyltransferase,3-methyl-2-oxobutanoate hydroxymethyltransferase,Ketopantoate hydroxymethyltransferase,3-methyl-2-oxobutanoate hydroxymethyltransferase,Ketopantoate hydroxymethyltransferase) b0134(3-methyl-2-oxobutanoate hydroxymethyltransferase) BN373_06311(3-methyl-2-oxobutanoate hydroxymethyltransferase) t0183(3-methyl-2-oxobutanoate hydroxymethyltransferase) SL1344_0183(3-methyl-2-oxobutanoate hydroxymethyltransferase) Cluster1868 1 1 1 1 1 1 1 ROD_01431(aspartate L-decarboxylase) ENC_46540(L-aspartate-alpha-decarboxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3853(Aspartate 1-decarboxylase precursor,aspartate alpha-decarboxylase,aspartate 1-decarboxylase,Aspartate decarboxylase) b0131(aspartate 1-decarboxylase) BN373_06291(aspartate 1-decarboxylase) t0181(aspartate 1-decarboxylase) SL1344_0181(aspartate 1-decarboxylase) Cluster1869 1 1 1 1 1 1 1 ROD_01421(putative polysaccharide deacetylase) ENC_46460(Predicted xylanase/chitin deacetylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3854(Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase precursor,outer membrane N-deacetylase,intercellular adhesin biosynthesis polysaccharide N-deacetylase,Polysaccharide deacetylase) b0130(predicted polysaccharide deacetylase lipoprotein) BN373_06281(polysaccharide deacetylase domain protein) t0180(conserved hypothetical protein) SL1344_0180(conserved hypothetical protein) Cluster1870 1 1 1 1 1 1 1 ROD_01411(PTS system IIA component) ENC_46450(Phosphotransferase system, mannose/fructose-specific component IIA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3855(EIIAB-Man,PTS system mannose-specific transporter subunits IIAB,PTS system, mannose/fructose/sorbose family, IIA component,PTS system fructose IIA component) b0129(predicted PTS Enzyme IIA) BN373_06271(PTS system, IIA component) t0179(putative IIA component of PTS system) SL1344_0179(putative PTS system IIA component) Cluster1871 1 1 1 1 1 1 1 ROD_01401(ABC transporter, permease protein) ENC_46440(ABC-type polysaccharide/polyol phosphate export systems, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3856(Inner membrane transport permease yadH,inner membrane transport permease,ATP phosphoribosyltransferase,daunorubicin resistance ABC transporter membrane protein,ABC-2 type transporter) b0128(predicted transporter subunit: membrane component of ABC superfamily) BN373_06261(ABC transporter, permease protein) t0177(ABC transporter integral membrane protein) SL1344_0174(ABC transporter integral membrane protein) Cluster1872 1 1 1 1 1 1 1 ROD_01381(carbonic anhydrase 2) ENC_46420(Carbonic anhydrase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3858(Carbonic anhydrase 2,carbonic anhydrase,Carbonic anhydrase,Carbonic anhydrase) b0126(carbonic anhydrase) BN373_06241(carbonate dehydratase) t0176(carbonic anhydrase) SL1344_0172(carbonic anhydrase) Cluster1873 1 1 1 1 1 1 1 ROD_01371(hypoxanthine phosphoribosyltransferase) ENC_46410(hypoxanthine phosphoribosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3859(Hypoxanthine phosphoribosyltransferase,hypoxanthine phosphoribosyltransferase,Predicted ATPase of the PP-loop superfamily implicated in cell cycle control,hypoxanthine phosphoribosyltransferase,Phosphoribosyl transferase domain) b0125(hypoxanthine phosphoribosyltransferase) BN373_06231(hypoxanthine phosphoribosyltransferase) t0175(hypoxanthine phosphoribosyltransferase) SL1344_0171(hypoxanthine phosphoribosyltransferase) Cluster1874 1 1 1 1 1 1 1 ROD_01341(blue copper oxidase precursor (copper efflux oxidase)) ENC_46390(cell division protein SufI) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3861(Copper efflux oxidase,multicopper oxidase,copper-resistance protein, CopA family,Multicopper oxidase) b0123(multicopper oxidase (laccase)) BN373_06211(copper oxidase CueO) t0173(possible multicopper oxidase precursor) SL1344_0169(possible multicopper oxidase precursor) Cluster1875 1 1 1 1 1 1 1 ROD_01331(conserved hypothetical protein) ENC_46380(Bacterial chaperone lipoprotein (PulS_OutS).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3862(lipoprotein, PulS/OutS family,Bacterial chaperone lipoprotein (PulS_OutS)) b0122(conserved protein, PulS_OutS family) BN373_06201(conserved hypothetical protein) t0172(conserved hypothetical protein) SL1344_0168(conserved hypothetical protein) Cluster1876 1 1 1 1 1 1 1 ROD_01321(spermidine synthase) ENC_46370(spermidine synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3863(Spermidine synthase,spermidine synthase,Spermidine synthase,spermidine synthase,Spermine/spermidine synthase) b0121(spermidine synthase (putrescine aminopropyltransferase)) BN373_06171(spermidine synthase) t0171(spermidine synthase) SL1344_0167(Spermidine synthase) Cluster1877 1 1 1 1 1 1 1 ROD_01261(conserved hypothetical protein) ENC_46350(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3865(hypothetical protein,Uncharacterised protein family (UPF0231)) b0119(conserved protein) BN373_06151(conserved hypothetical protein) t0165(conserved hypothetical protein) SL1344_0161(conserved hypothetical protein) Cluster1878 1 1 1 1 1 1 1 ROD_01251(aconitate hydratase 2 (citrate hydro-lyase 2)) ENC_46340(aconitase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3866(Aconitate hydratase 2,bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase,3-isopropylmalate dehydratase large subunit,aconitate hydratase 2,Aconitate hydratase 2 N-terminus) b0118(bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase) BN373_06141(aconitate hydratase 2) t0164(aconitate hydratase 2) SL1344_0159(aconitate hydratase 2 (citrate hydro-lyase 2)) Cluster1879 1 1 1 1 1 1 1 ROD_01221(dihydrolipoyl dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes)) ENC_46290(dihydrolipoamide dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3868(Dihydrolipoyl dehydrogenase,dihydrolipoamide dehydrogenase,Uncharacterized conserved protein,dihydrolipoyl dehydrogenase,Pyridine nucleotide-disulphide oxidoreductase) b0116(lipoamide dehydrogenase, E3 component is part of three enzyme complexes) BN373_06101(dihydrolipoamide dehydrogenase) t0160(dihydrolipoamide dehydrogenase) SL1344_0154(dihydrolipoamide dehydrogenase) Cluster1880 1 1 1 1 1 1 1 ROD_01211(dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase) ENC_46280(pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3869(Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex,pyruvate dehydrogenase dihydrolipoyltransacetylase,Acetyl/propionyl-CoA carboxylase, alpha subunit,dihydrolipoyllysine-residue acetyltransferase,2-oxoacid dehydrogenases acyltransferase (catalytic domain)) b0115(pyruvate dehydrogenase, dihydrolipoyltransacetylase component E2) BN373_06091(dihydrolipoyllysine-residue acetyltransferase) t0159(dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase) SL1344_0153(dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase) Cluster1881 1 1 1 1 1 1 1 ROD_01201(pyruvate dehydrogenase E1 component) ENC_46270(pyruvate dehydrogenase E1 component, homodimeric type) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3870(Pyruvate dehydrogenase E1 component,pyruvate dehydrogenase subunit E1,Pyruvate dehydrogenase complex, dehydrogenase (E1) component,pyruvate dehydrogenase (acetyl-transferring), homodimeric type,Transketolase, thiamine diphosphate binding domain) b0114(pyruvate dehydrogenase, decarboxylase component E1, thiamin-binding) BN373_06081(pyruvate dehydrogenase (acetyl-transferring), homodimeric type) t0158(pyruvate dehydrogenase E1 component) SL1344_0152(pyruvate dehydrogenase E1 component) Cluster1882 1 1 1 1 1 1 1 ROD_01191(pyruvate dehydrogenase complex repressor) ENC_46260(transcriptional regulator, GntR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3872(Pyruvate dehydrogenase complex repressor,transcriptional regulator PdhR,Transcriptional regulators,phosphonate metabolism transcriptional regulator PhnF,Bacterial regulatory proteins, gntR family) b0113(DNA-binding transcriptional dual regulator) BN373_06071(pyruvate dehydrogenase complex repressor) t0157(pyruvate dehydrogenase complex repressor) SL1344_0151(pyruvate dehydrogenase complex repressor) Cluster1883 1 1 1 1 1 1 1 ROD_01151(AmpE protein) ENC_46220(Membrane protein required for beta-lactamase induction) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3879(hypothetical protein,regulatory protein AmpE,Membrane protein required for beta-lactamase induction,CobD/Cbib protein) b0111(predicted inner membrane protein) BN373_06031(protein AmpE) t0153(AmpE protein) SL1344_0147(AmpE protein) Cluster1884 1 1 1 1 1 1 1 ROD_01141(N-acetyl-anhydromuramyl-L-alanine-amidase) ENC_46210(Negative regulator of beta-lactamase expression) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3880(1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD,N-acetyl-anhydromuranmyl-L-alanine amidase,N-acetylmuramoyl-L-alanine amidase) b0110(1,6-anhydro-N-acetylmuramyl-L-alanine amidase, Zn-dependent; murein amidase) BN373_06021(N-acetylmuramoyl-L-alanine amidase) t0152(anhydro-N-acetylmuramyl-tripeptide amidase) SL1344_0146(AmpD protein (anhydro-N-acetylmuramyl-tripeptide amidase)) Cluster1885 1 1 1 1 1 1 1 ROD_01131(nicotinate-nucleotide pyrophosphorylase [carboxylating]) ENC_46200(nicotinate-nucleotide pyrophosphorylase [carboxylating]) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3881(Nicotinate-nucleotide pyrophosphorylase [carboxylating],quinolinate phosphoribosyltransferase,Aspartate oxidase,nicotinate-nucleotide diphosphorylase (carboxylating),Quinolinate phosphoribosyl transferase, C-terminal domain) b0109(quinolinate phosphoribosyltransferase) BN373_06011(nicotinate-nucleotide diphosphorylase (carboxylating)) t0151(nicotinate-nucleotide pyrophosphorylase) SL1344_0145(nicotinate-nucleotide pyrophosphorylase) Cluster1886 1 1 1 1 1 1 1 ROD_01121(prepilin peptidase dependent protein D precursor) ENC_46190(prepilin-type N-terminal cleavage/methylation domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3882(Pilin,putative major pilin subunit,Tfp pilus assembly protein, major pilin PilA,prepilin-type N-terminal cleavage/methylation domain,Prokaryotic N-terminal methylation motif) b0108(predicted major pilin subunit) BN373_05991(type IV pilus protein) t0150(prepilin peptidase dependent protein D precursor) SL1344_0144(prepilin peptidase dependent protein D precursor) Cluster1887 1 1 1 1 1 1 1 ROD_01111(protein transport protein HofB) ENC_46180(Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3883(Type II traffic warden ATPase,hypothetical protein,Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB,type IV-A pilus assembly ATPase PilB,Type II/IV secretion system protein) b0107(conserved protein with nucleoside triphosphate hydrolase domain) BN373_05981(protein transport protein HofB) t0149(transport protein HofB) SL1344_0143(protein transport protein HofB) Cluster1888 1 1 1 1 1 1 1 ROD_01101(protein transport protein HofC) ENC_46170(Type II secretory pathway, component PulF) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3884(Cholera toxin secretion protein epsF,type IV pilin biogenesis protein,type II secretion system protein F,Bacterial type II secretion system protein F domain) b0106(assembly protein in type IV pilin biogenesis, transmembrane protein) BN373_05971(protein transport protein HofC) t0148(transport protein HofC) SL1344_0142(protein transport protein HofC) Cluster1889 1 1 1 1 1 1 1 ROD_01081(dephospho-CoA kinase) ENC_46140(dephospho-CoA kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3886(Dephospho-CoA kinase,dephospho-CoA kinase,Dephospho-CoA kinase,dephospho-CoA kinase,Dephospho-CoA kinase) b0103(dephospho-CoA kinase) BN373_05951(dephospho-CoA kinase) t0146(conserved hypothetical protein) SL1344_0140(Dephospho-CoA kinase) Cluster1890 1 1 1 1 1 1 1 ROD_01071(conserved hypothetical protein) ENC_46130(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3887(hypothetical protein,hypothetical protein,Protein of unknown function (DUF1342)) b0102(conserved protein) BN373_05941(conserved hypothetical protein) t0145(conserved hypothetical protein) SL1344_0139(conserved hypothetical protein) Cluster1891 1 1 1 1 1 1 1 ROD_01061(conserved hypothetical protein) ENC_46120(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3888(DNA gyrase inhibitor YacG,DNA gyrase inhibitor,Domain of unknown function (DUF329)) b0101(DNA gyrase inhibitor) BN373_05931(zinc-binding protein YacG) t0144(conserved hypothetical protein) SL1344_0138(conserved hypothetical protein) Cluster1892 1 1 1 1 1 1 1 ROD_01051(mutator protein (7,8-dihydro-8-oxoguanine-triphosphatase)) ENC_46110(8-oxo-dGTPase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3889(8-oxo-dGTP diphosphatase,nucleoside triphosphate pyrophosphohydrolase,NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding,mutator mutT protein,NUDIX domain) b0099(nucleoside triphosphate pyrophosphohydrolase, marked preference for dGTP) BN373_05921(mutator mutT protein) t0141(7,8-dihydro-8-oxoguanine-triphosphatase) SL1344_0137(7,8-dihydro-8-oxoguanine-triphosphatase) Cluster1893 1 1 1 1 1 1 1 ROD_01031(secretion monitor precursor) ENC_46090(Secretion monitor precursor protein (SecM).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3891(Secretion monitor precursor,SecA regulator SecM,Secretion monitor precursor protein (SecM)) b0097(regulator of secA translation) BN373_05901(secretion monitor protein) t0139(conserved hypothetical protein) SL1344_0135(conserved hypothetical protein) Cluster1894 1 1 1 1 1 1 1 ROD_01021(UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase) ENC_46080(UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3892(UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase,UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase,UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase,UDP-3-O-acyl N-acetylglycosamine deacetylase) b0096(UDP-3-O-acyl N-acetylglucosamine deacetylase) BN373_05891(UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase) t0138(UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase) SL1344_0134(UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase) Cluster1895 1 1 1 1 1 1 1 ROD_01011(cell division protein FtsZ) ENC_46070(cell division protein FtsZ) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3893(Cell division protein FtsZ,cell division protein FtsZ,Cell division GTPase,cell division protein FtsZ,FtsZ family, C-terminal domain) b0095(GTP-binding tubulin-like cell division protein) BN373_05881(cell division protein FtsZ) t0137(cell division protein FtsZ) SL1344_0133(cell division protein FtsZ) Cluster1896 1 1 1 1 1 1 1 ROD_01001(cell division protein FtsA) ENC_46060(cell division protein FtsA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3894(Cell division protein FtsA,cell division protein FtsA,Ethanolamine utilization protein, possible chaperonin,cell division protein FtsA,Cell division protein FtsA) b0094(ATP-binding cell division protein involved in recruitment of FtsK to Z ring) BN373_05871(cell division protein FtsA) t0136(cell division protein FtsA) SL1344_0132(cell division protein FtsA) Cluster1897 1 1 1 1 1 1 1 ROD_00991(cell division protein FtsQ) ENC_46050(Cell division septal protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3895(Cell division protein FtsQ,cell division protein FtsQ,Cell division protein FtsQ) b0093(Divisome assembly protein, membrane anchored protein involved in growth of wall at septum) BN373_05861(cell division protein FtsQ) t0135(cell division protein FtsQ) SL1344_0131(cell division protein FtsQ) Cluster1898 1 1 1 1 1 1 1 ROD_00981(D-alanine--D-alanine ligase B) ENC_46040(D-alanine--D-alanine ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3896(D-alanine--D-alanine ligase B,D-alanine--D-alanine ligase,Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase),D-alanine--D-alanine ligase,D-ala D-ala ligase C-terminus) b0092(D-alanine:D-alanine ligase) BN373_05851(D-alanine--D-alanine ligase B) t0134(D-alanine:D-alanine ligase B) SL1344_0130(D-alanine--D-alanine ligase) Cluster1899 1 1 1 1 1 1 1 ROD_00971(UDP-N-acetylmuramate:alanine ligase) ENC_46030(UDP-N-acetylmuramate--L-alanine ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3897(UDP-N-acetylmuramate--L-alanine ligase,UDP-N-acetylmuramate--L-alanine ligase,Folylpolyglutamate synthase,UDP-N-acetylmuramate--alanine ligase,Mur ligase middle domain) b0091(UDP-N-acetylmuramate:L-alanine ligase) BN373_05841(UDP-N-acetylmuramate--alanine ligase) t0133(UDP-N-acetylmuramate:alanine ligase) SL1344_0129(UDP-N-acetylmuramate--L-alanine ligase) Cluster1900 1 1 1 1 1 1 1 ROD_00961(UDP-N-acetylglucosamine--N-acetylmuramyl-(penta peptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase) ENC_46020(UDP-N-acetylglucosamine--N-acetylmuramyl-(pentape ptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3898(UDP-N-acetylglucosamine--N-acetylmuramyl-(pentape ptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase,undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase,Predicted glycosyl transferase,undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase,Glycosyltransferase family 28 N-terminal domain) b0090(N-acetylglucosaminyl transferase) BN373_05831(undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase) t0132(UDP-N-acetylglucosamine:N-acetylmuramyl-(pentapeptide)-pyrophosphoryl-undecaprenol N-acetylglucosamine transferase) SL1344_0128(UDP-N-acetylglucosamine--N-acetylmuramyl-) Cluster1901 1 1 1 1 1 1 1 ROD_00951(cell division protein FtsW) ENC_46010(cell division-specific peptidoglycan biosynthesis regulator FtsW) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3899(Cell division protein FtsW,cell division protein FtsW,cell division protein FtsW,Cell cycle protein) b0089(Lipid II flippase; integral membrane protein involved in stabilizing FstZ ring during cell division) BN373_05821(cell division protein FtsW) t0131(cell division protein FtsW) SL1344_0127(cell division protein FtsW) Cluster1902 1 1 1 1 1 1 1 ROD_00941(UDP-N-acetylmuramoylalanine--D-glutamate ligase) ENC_46000(UDP-N-acetylmuramoylalanine--D-glutamate ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3900(UDP-N-acetylmuramoylalanine--D-glutamate ligase,UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase,Folylpolyglutamate synthase,UDP-N-acetylmuramoylalanine--D-glutamate ligase,Mur ligase middle domain) b0088(UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase) BN373_05811(UDP-N-acetylmuramoylalanine--D-glutamate ligase) t0130(UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase) SL1344_0126(UDP-N-acetylmuramoylalanine--D-glutamate ligase) Cluster1903 1 1 1 1 1 1 1 ROD_00931(phospho-N-acetylmuramoyl-pentapeptide-transfera se) ENC_45990(Phospho-N-acetylmuramoyl-pentapeptide-transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3901(Phospho-N-acetylmuramoyl-pentapeptide-transferase ,phospho-N-acetylmuramoyl-pentapeptide-transferase,phospho- N-acetylmuramoyl-pentapeptide-transferase,Glycosyl transferase family 4) b0087(phospho-N-acetylmuramoyl-pentapeptide transferase) BN373_05801(phospho-N-acetylmuramoyl-pentapeptide-transfera se) t0129(phospho-N-acetylmuramoyl-pentapeptide-transferase) SL1344_0125(Phospho-N-acetylmuramoyl-pentapeptide-transfera se) Cluster1904 1 1 1 1 1 1 1 ROD_00921(UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-ala nine ligase) ENC_45980(UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3902(UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alani ne ligase,UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase,Folylpolyglutamate synthase,UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanin e ligase,Mur ligase middle domain) b0086(UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase) BN373_05791(UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-ala nine ligase) t0128(UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diami nopimelate--D-alan alanyl ligase) SL1344_0124(UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diami nopimelate--D-alan alanyl ligase) Cluster1905 1 1 1 1 1 1 1 ROD_00911(UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-dia minopimelate ligase) ENC_45970(UDP-N-acetylmuramyl-tripeptide synthetases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3903(UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-di aminopimelate ligase,UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminop imelate ligase,Folylpolyglutamate synthase,UDP-N-acetylmuramyl-tripeptide synthetase,Mur ligase middle domain) b0085(UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-diaminopimelate ligase) BN373_05781(UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase) t0127(UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-dia minopim ligase) SL1344_0123(UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-dia minopimelate ligase) Cluster1906 1 1 1 1 1 1 1 ROD_00891(cell division protein FtsL) ENC_45950(cell division protein FtsL) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3905(Cell division protein FtsL,cell division protein FtsL,Cell division protein,cell division protein FtsL,Cell division protein FtsL) b0083(membrane bound cell division protein at septum containing leucine zipper motif) BN373_05761(cell division protein FtsL) t0125(cell division protein FtsL) SL1344_0121(cell division protein FtsL) Cluster1907 1 1 1 1 1 1 1 ROD_00881(S-adenosyl-L-methionine-dependent methyltransferase) ENC_45940(S-adenosyl-methyltransferase MraW) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3906(Ribosomal RNA small subunit methyltransferase H,16S rRNA m(4)C1402 methyltranserfase,S-adenosyl-methyltransferase MraW,MraW methylase family) b0082(16S rRNA m(4)C1402 methyltranserfase, SAM-dependent) BN373_05751(S-adenosyl-methyltransferase MraW) t0124(conserved hypothetical protein) SL1344_0120(S-adenosyl-methyltransferase) Cluster1908 1 1 1 1 1 1 1 ROD_00871(conserved hypothetical protein) ENC_45930(mraZ protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3907(hypothetical protein,cell division protein MraZ,protein MraZ,MraZ protein) b0081(RsmH methytransferase inhibitor) BN373_05741(MraZ protein) t0123(conserved hypothetical protein) SL1344_0119(conserved hypothetical protein) Cluster1909 1 1 1 1 1 1 1 ROD_00851(acetolactate synthase isozyme III small subunit) ENC_45910(acetolactate synthase, small subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3909(Acetolactate synthase isozyme 3 small subunit,acetolactate synthase 3 regulatory subunit,Acetolactate synthase (isozyme II), small (regulatory) subunit,acetolactate synthase, small subunit,Small subunit of acetolactate synthase) b0078(acetolactate synthase III, thiamin-dependent, small subunit) BN373_05721(acetolactate synthase, small subunit, isozyme III) t0121(acetolactate synthase isozyme III small subunit) SL1344_0117(acetolactate synthase isozyme III small subunit) Cluster1910 1 1 1 1 1 1 1 ROD_00841(acetolactate synthase isozyme III large subunit) ENC_45900(acetolactate synthase, large subunit, biosynthetic type) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3910(Acetolactate synthase isozyme 3 large subunit,acetolactate synthase 3 catalytic subunit,Glyoxylate carboligase,acetolactate synthase, large subunit, biosynthetic type,Thiamine pyrophosphate enzyme, N-terminal TPP binding domain) b0077(acetolactate synthase III, large subunit) BN373_05711(acetolactate synthase, large subunit, isozyme III) t0120(acetolactate synthase isozyme III large subunit) SL1344_0116(acetolactate synthase isozyme III large subunit) Cluster1911 1 1 1 1 1 1 1 ROD_00831(LysR-family transcriptional regulator) ENC_10270(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3911(HTH-type transcriptional regulator LeuO,leucine transcriptional activator,putative choline sulfate-utilization transcription factor,Bacterial regulatory helix-turn-helix protein, lysR family) b0076(DNA-binding transcriptional activator) BN373_05701(transcriptional regulator LeuO) t0119(probable activator protein in leuABCD operon) SL1344_0115(probable activator protein in leuABCD operon) Cluster1912 1 1 1 1 1 1 1 ROD_00811(3-isopropylmalate dehydrogenase) ENC_45870(3-isopropylmalate dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3914(3-isopropylmalate dehydrogenase,3-isopropylmalate dehydrogenase,3-isopropylmalate dehydrogenase,Isocitrate/isopropylmalate dehydrogenase) b0073(3-isopropylmalate dehydrogenase, NAD(+)-dependent) BN373_05671(3-isopropylmalate dehydrogenase) t0116(3-isopropylmalate dehydrogenase) SL1344_0112(3-isopropylmalate dehydrogenase) Cluster1913 1 1 1 1 1 1 1 ROD_00801(3-isopropylmalate dehydratase large subunit) ENC_45860(3-isopropylmalate dehydratase, large subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3915(3-isopropylmalate dehydratase large subunit,isopropylmalate isomerase large subunit,3-isopropylmalate dehydratase large subunit,3-isopropylmalate dehydratase, large subunit,Aconitase family (aconitate hydratase)) b0072(3-isopropylmalate dehydratase large subunit) BN373_05661(3-isopropylmalate dehydratase, large subunit) t0115(3-isopropylmalate dehydratase) SL1344_0111(3-isopropylmalate dehydratase large subunit) Cluster1914 1 1 1 1 1 1 1 ROD_00791(3-isopropylmalate dehydratase small subunit) ENC_45850(3-isopropylmalate dehydratase, small subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3916(3-isopropylmalate dehydratase small subunit,isopropylmalate isomerase small subunit,3-isopropylmalate dehydratase large subunit,3-isopropylmalate dehydratase, small subunit,Aconitase C-terminal domain) b0071(3-isopropylmalate dehydratase small subunit) BN373_05651(3-isopropylmalate dehydratase, small subunit) t0114(3-isopropylmalate dehydratase) SL1344_0110(3-isopropylmalate dehydratase small subunit) Cluster1915 1 1 1 1 1 1 1 ROD_00761(putative substrate-binding protein) ENC_45820(ABC-type uncharacterized transport system, periplasmic component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3918(HTH-type transcriptional regulator sgrR,transcriptional regulator SgrR,ABC-type uncharacterized transport system, periplasmic component,Sugar transport-related sRNA regulator N-term) b0069(transcriptional DNA-binding transcriptional activator of sgrS sRNA) BN373_05561(sugar transport-related sRNA regulator SgrR) t0113(putative ABC transporter periplasmic solute binding protein) SL1344_0109(putative ABC transporter periplasmic solute binding protein) Cluster1916 1 1 1 1 1 1 1 ROD_00731(thiamine ABC transport system, ATP-binding protein) ENC_45790(thiamine ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3922(Thiamine import ATP-binding protein ThiQ,thiamine transporter ATP-binding subunit,ABC-type thiamine transport system, ATPase component,thiamine ABC transporter, ATP-binding protein,ABC transporter) b0066(thiamin transporter subunit) BN373_05531(thiamine ABC transporter, ATP-binding protein) t0110(hypothetical ABC transporter) SL1344_0106(hypothetical ABC transporter) Cluster1917 1 1 1 1 1 1 1 ROD_00721(putative membrane protein) ENC_45780(Uncharacterized membrane-associated protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3923(Inner membrane protein yabI,hypothetical protein,SNARE associated Golgi protein) b0065(inner membrane protein, SNARE_assoc family) BN373_05521(putative membrane protein) t0109(DedA-family integral membrane protein) SL1344_0105(DedA family integral membrane protein) Cluster1918 1 1 1 1 1 1 1 ROD_00711(arabinose operon regulatory protein) ENC_45770(transcriptional regulator, AraC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3929(Arabinose operon regulatory protein,DNA-binding transcriptional regulator AraC,Adenosine deaminase,YSIRK-targeted surface antigen transcriptional regulator,AraC-like ligand binding domain) b0064(DNA-binding transcriptional dual regulator) BN373_05511(arabinose operon regulatory protein) t0108(arabinose operon regulatory protein) SL1344_0104(arabinose operon regulatory protein) Cluster1919 1 1 1 1 1 1 1 ROD_00701(ribulokinase) ENC_45760(L-ribulokinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3930(Ribulokinase,ribulokinase,Pentose-5-phosphate-3-e pimerase,L-ribulokinase,FGGY family of carbohydrate kinases, C-terminal domain) b0063(L-ribulokinase) BN373_05501(L-ribulokinase) t0107(L-ribulokinase) SL1344_0103(Ribulokinase) Cluster1920 1 1 1 1 1 1 1 ROD_00691(L-arabinose isomerase) ENC_45750(L-arabinose isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3931(L-arabinose isomerase,L-arabinose isomerase,L-fucose isomerase and related proteins,L-arabinose isomerase) b0062(L-arabinose isomerase) BN373_05491(L-arabinose isomerase) t0106(L-arabinose isomerase) SL1344_0102(L-arabinose isomerase) Cluster1921 1 1 1 1 1 1 1 ROD_00671(L-ribulose-5-phosphate 4-epimerase) ENC_45740(L-ribulose 5-phosphate 4-epimerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3932(L-ribulose-5-phosphate 4-epimerase,L-ribulose-5-phosphate 4-epimerase,Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases,L-ribulose-5-phosphate 4-epimerase,Class II Aldolase and Adducin N-terminal domain) b0061(L-ribulose-5-phosphate 4-epimerase) BN373_05481(L-ribulose-5-phosphate 4-epimerase) t0105(L-ribulose-5-phosphate 4-epimerase) SL1344_0101(L-ribulose-5-phosphate 4-epimerase) Cluster1922 1 1 1 1 1 1 1 ROD_00641(RNA polymerase-associated protein) ENC_45720(Superfamily II DNA/RNA helicases, SNF2 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3934(RNA polymerase-associated protein rapA,ATP-dependent helicase HepA,N-formylmethionyl-tRNA deformylase,ATP-dependent DNA helicase RecQ,RNA polymerase recycling family C-terminal) b0059(RNA polymerase-associated helicase protein (ATPase and RNA polymerase recycling factor)) BN373_05451(RNA polymerase associated protein RapA) t0099(probable ATP-dependent helicase HepA) SL1344_0097(probable ATP-dependent helicase HepA) Cluster1923 1 1 1 1 1 1 1 ROD_00631(ribosomal large subunit pseudouridine synthase A) ENC_45710(ribosomal large subunit pseudouridine synthase A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3935(Ribosomal large subunit pseudouridine synthase A,23S rRNA/tRNA pseudouridine synthase A,pseudouridine synthase, RluA family,RNA pseudouridylate synthase) b0058(pseudouridine synthase for 23S rRNA (position 746) and tRNAphe(position 32)) BN373_05441(pseudouridine synthase, RluA family) t0098(ribosomal large subunit pseudouridine synthase A) SL1344_0096(ribosomal large subunit pseudouridine synthase A) Cluster1924 1 1 1 1 1 1 1 ROD_00621(DnaJ-like protein) ENC_45700(DnaJ-domain-containing proteins 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3936(DnaJ-like protein DjlA,Dna-J like membrane chaperone protein,Preprotein translocase subunit Sec63,chaperone protein DnaJ,DnaJ domain) b0055(DnaJ-like protein, membrane anchored) BN373_05391(protein DjlA, DnaJ family) t0097(DnaJ-like protein) SL1344_0095(DnaJ-like protein) Cluster1925 1 1 1 1 1 1 1 ROD_00601(chaperone precursor (peptidyl-prolyl cis-trans isomerase)) ENC_45680(Parvulin-like peptidyl-prolyl isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3938(Peptidyl-prolyl cis-trans isomerase surA,peptidyl-prolyl cis-trans isomerase SurA,nitrogen fixation protein NifM,PPIC-type PPIASE domain) b0053(peptidyl-prolyl cis-trans isomerase (PPIase)) BN373_05371(chaperone/peptidyl-prolyl cis-trans isomerase SurA) t0095(survival protein SurA precursor) SL1344_0093(survival protein SurA precursor) Cluster1926 1 1 1 1 1 1 1 ROD_00591(4-hydroxythreonine-4-phosphate dehydrogenase) ENC_45670(4-hydroxythreonine-4-phosphate dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3939(4-hydroxythreonine-4-phosphate dehydrogenase,4-hydroxythreonine-4-phosphate dehydrogenase,4-hydroxythreonine-4-phosphate dehydrogenase,Pyridoxal phosphate biosynthetic protein PdxA) b0052(4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent) BN373_05361(4-hydroxythreonine-4-phosphate dehydrogenase) t0094(pyridoxal phosphate biosynthetic protein PdxA) SL1344_0092(pyridoxal phosphate biosynthetic protein PdxA) Cluster1927 1 1 1 1 1 1 1 ROD_00581(dimethyladenosine transferase (S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase)) ENC_45660(dimethyladenosine transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3940(Ribosomal RNA small subunit methyltransferase A,16S ribosomal RNA methyltransferase KsgA/Dim1 family protein,Dimethyladenosine transferase (rRNA methylation),dimethyladenosine transferase,Ribosomal RNA adenine dimethylase) b0051(16S rRNA dimethyladenosine transferase, SAM-dependent) BN373_05351(dimethyladenosine transferase) t0093(dimethyladenosine transferase) SL1344_0091(dimethyladenosine transferase) Cluster1928 1 1 1 1 1 1 1 ROD_00571(conserved hypothetical protein) ENC_45650(Uncharacterized protein affecting Mg2+/Co2+ transport) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3941(hypothetical protein,CO2+/MG2+ efflux protein ApaG,Uncharacterized protein affecting Mg2+/Co2+ transport,Protein of unknown function (DUF525)) b0050(protein associated with Co2+ and Mg2+ efflux) BN373_05341(protein ApaG) t0092(CorD protein) SL1344_0090(CorD protein) Cluster1929 1 1 1 1 1 1 1 ROD_00561(bis(5'-nucleosyl)-tetraphosphatase) ENC_45640(bis(5'-nucleosyl)-tetraphosphatase (symmetrical)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3942(Bis(5'-nucleosyl)-tetraphosphatase [symmetrical],diadenosine tetraphosphatase,Predicted kinase,bis(5'-nucleosyl)-tetraphosphatase (symmetrical),Calcineurin-like phosphoesterase) b0049(diadenosine tetraphosphatase) BN373_05331(bis(5'-nucleosyl)-tetraphosphatase (symmetrical)) t0091(bis(5'-nucleosyl)-tetraphosphatase) SL1344_0089(bis(5'-nucleosyl)-tetraphosphatase) Cluster1930 1 1 1 1 1 1 1 ROD_00531(glutathione-regulated potassium-efflux system protein) ENC_45620(Kef-type potassium/proton antiporter, CPA2 family (TC 2.A.37.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3946(K(+)/H(+) antiporter,glutathione-regulated potassium-efflux system protein KefC,Kef-type K+ transport system, predicted NAD-binding component,transporter, monovalent cation:proton antiporter-2 (CPA2) family,Sodium/hydrogen exchanger family) b0047(potassium:proton antiporter) BN373_05311(glutathione-regulated potassium-efflux system protein KefC) t0089(glutathione-regulated potassium-efflux system protein KefC) SL1344_0087(glutathione-regulated potassium-efflux system protein KefC) Cluster1931 1 1 1 1 1 1 1 ROD_00521(glutathione-regulated potassium-efflux system ancillary protein) ENC_45610(Putative NADPH-quinone reductase (modulator of drug activity B)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3947(Glutathione-regulated potassium-efflux system ancillary protein kefF,glutathione-regulated potassium-efflux system ancillary protein KefF,Putative NADPH-quinone reductase (modulator of drug activity B),Flavodoxin-like fold) b0046(potassium-efflux system ancillary protein for KefC, glutathione-regulated; quinone oxidoreductase, FMN-dependent) BN373_05301(glutathione-regulated potassium-efflux system ancillary protein KefF) t0088(putative NAD(P)H oxidoreductase) SL1344_0086(putative NAD(P)H oxidoreductase) Cluster1932 1 1 1 1 1 1 1 ROD_00361(carbamoyl-phosphate synthase large chain) ENC_45580(carbamoyl-phosphate synthase large subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3961(Carbamoyl-phosphate synthase large chain,carbamoyl phosphate synthase large subunit,Carbamoylphosphate synthase small subunit,carbamoyl-phosphate synthase, large subunit,Carbamoyl-phosphate synthase L chain, ATP binding domain) b0033(carbamoyl-phosphate synthase large subunit) BN373_05281(carbamoyl-phosphate synthase, large subunit) t0068(carbamoyl-phosphate synthase large chain) SL1344_0068(carbamoyl-phosphate synthase large chain) Cluster1933 1 1 1 1 1 1 1 ROD_00351(carbamoyl-phosphate synthase small chain) ENC_45570(carbamoyl-phosphate synthase, small subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3962(Carbamoyl-phosphate synthase small chain,carbamoyl phosphate synthase small subunit,Carbamoylphosphate synthase small subunit,carbamoyl-phosphate synthase, small subunit,Carbamoyl-phosphate synthase small chain, CPSase domain) b0032(carbamoyl phosphate synthetase small subunit, glutamine amidotransferase) BN373_05271(carbamoyl-phosphate synthase, small subunit) t0067(carbamoyl-phosphate synthase small chain) SL1344_0067(carbamoyl-phosphate synthase small chain) Cluster1934 1 1 1 1 1 1 1 ROD_00341(dihydrodipicolinate reductase) ENC_45560(dihydrodipicolinate reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3963(Dihydrodipicolinate reductase,dihydrodipicolinate reductase,Dihydrodipicolinate reductase,dihydrodipicolinate reductase,Dihydrodipicolinate reductase, C-terminus) b0031(dihydrodipicolinate reductase) BN373_05241(dihydrodipicolinate reductase) t0066(dihydrodipicolinate reductase) SL1344_0065(dihydrodipicolinate reductase) Cluster1935 1 1 1 1 1 1 1 ROD_00251(FkbB-type 16 kD peptidyl-prolyl cis-trans isomerase) ENC_45450(FKBP-type peptidyl-prolyl cis-trans isomerases 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3967(FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase,FKBP-type peptidyl-prolyl cis-trans isomerase,FKBP-type peptidyl-prolyl cis-trans isomerase) b0028(FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase)) BN373_05041(FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase) t0050(probable FkbB-type 16 kD peptidyl-prolyl cis-trans isomerase) SL1344_0049(probable FkbB-type 16 kD peptidyl-prolyl cis-trans isomerase) Cluster1936 1 1 1 1 1 1 1 ROD_00241(lipoprotein signal peptidase) ENC_45440(signal peptidase II . Aspartic peptidase. MEROPS family A08) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3968(Lipoprotein signal peptidase,lipoprotein signal peptidase,signal peptidase II,Signal peptidase (SPase) II) b0027(prolipoprotein signal peptidase (signal peptidase II)) BN373_05031(signal peptidase II) t0049(lipoprotein signal peptidase) SL1344_0048(lipoprotein signal peptidase) Cluster1937 1 1 1 1 1 1 1 ROD_00231(isoleucyl-tRNA synthetase) ENC_45430(Isoleucyl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3969(Isoleucine--tRNA ligase,isoleucyl-tRNA synthetase,Isoleucyl-tRNA synthetase,isoleucine--tRNA ligase,tRNA synthetases class I (I, L, M and V)) b0026(isoleucyl-tRNA synthetase) BN373_05021(isoleucyl-tRNA synthetase) t0048(isoleucyl-tRNA synthetase) SL1344_0047(isoleucyl-tRNA synthetase) Cluster1938 1 1 1 1 1 1 1 ROD_00221(riboflavin biosynthesis protein) ENC_45420(FMN adenylyltransferase /riboflavin kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3970(Riboflavin biosynthesis protein ribF,bifunctional riboflavin kinase/FMN adenylyltransferase,FAD synthase,riboflavin biosynthesis protein RibF,FAD synthetase) b0025(bifunctional riboflavin kinase/FAD synthetase) BN373_05011(riboflavin biosynthesis protein RibF) t0047(riboflavin biosynthesis protein RibF) SL1344_0046(riboflavin biosynthesis protein RibF) Cluster1939 1 1 1 1 1 1 1 ROD_00212(30S ribosomal protein S20) ENC_45410(SSU ribosomal protein S20P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3971(30S ribosomal protein S20,30S ribosomal protein S20,Ribosomal protein S20,ribosomal protein S20,Ribosomal protein S20) b0023(30S ribosomal subunit protein S20) BN373_05001(ribosomal protein S20) t0045(30S ribosomal protein S20) SL1344_0044(30S ribosomal protein S20) Cluster1940 1 1 1 1 1 1 1 ROD_00171(transcriptional regulator) ENC_45400(transcriptional regulator, LysR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3974(Na(+)/H(+) antiporter regulatory protein,transcriptional activator NhaR,pca operon transcription factor PcaQ,Bacterial regulatory helix-turn-helix protein, lysR family) b0020(DNA-binding transcriptional activator) BN373_04991(transcriptional activator protein NhaR) t0042(transcriptional activator protein NhaR) SL1344_0041(transcriptional activator protein NhaR) Cluster1941 1 1 1 1 1 1 1 ROD_00111(chaperone protein DnaJ (heat shock protein J)) ENC_45380(chaperone protein DnaJ) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3980(Heat shock protein J,chaperone protein DnaJ,Preprotein translocase subunit Sec63,chaperone protein DnaJ,DnaJ C terminal domain) b0015(chaperone Hsp40, co-chaperone with DnaK) BN373_04971(chaperone protein DnaJ) t0013(DnaJ protein) SL1344_0013(DnaJ protein) Cluster1942 1 1 1 1 1 1 1 ROD_00101(chaperone protein DnaK (heat shock protein 70)) ENC_45370(chaperone protein DnaK) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3982(Heat shock protein 70,molecular chaperone DnaK,Ethanolamine utilization protein, possible chaperonin,chaperone protein DnaK,Hsp70 protein) b0014(chaperone Hsp70, co-chaperone with DnaJ) BN373_04961(chaperone protein DnaK) t0012(DnaK protein) SL1344_0012(Chaperone protein dnaK) Cluster1943 1 1 1 1 1 1 1 ROD_00091(putative membrane protein) ENC_45350(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3985(Inner membrane protein yaaH,hypothetical protein,GPR1/FUN34/yaaH family) b0010(inner membrane protein, Grp1_Fun34_YaaH family) BN373_04931(GPR1/FUN34/yaaH family protein) t0009(conserved hypothetical protein) SL1344_0009(conserved hypothetical protein) Cluster1944 1 1 1 1 1 1 1 ROD_00071(molybdopterin biosynthesis Mog protein) ENC_45330(molybdopterin adenylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3986(Molybdopterin adenylyltransferase,molybdenum cofactor biosynthesis protein MogA,Molybdopterin biosynthesis enzyme,molybdenum cofactor synthesis domain,Probable molybdopterin binding domain) b0009(molybdochelatase incorporating molybdenum into molybdopterin) BN373_04911(molybdopterin biosynthesis protein Mog) t0008(molybdopterin biosynthesis Mog protein) SL1344_0008(molybdopterin biosynthesis Mog protein) Cluster1945 1 1 1 1 1 1 1 ROD_00061(transaldolase B) ENC_45320(transaldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3987(Transaldolase B,transaldolase B,Transaldolase,transaldolase,Transaldolase) b0008(transaldolase B) BN373_04901(transaldolase B) t0007(transaldolase B) SL1344_0007(transaldolase B) Cluster1946 1 1 1 1 1 1 1 ROD_00051(putative transport protein) ENC_16080(amino acid carrier protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3988(Na+/alanine symporter,amino acid carrier protein,Sodium:alanine symporter family) b0007(predicted transporter) BN373_04891(sodium:alanine symporter family protein) t0006(putative amino-acid transport protein) SL1344_0006(putative amino-acid transport protein) Cluster1947 1 1 1 1 1 1 1 ROD_00041(conserved hypothetical protein) ENC_45300(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3989(hypothetical protein,hypothetical protein,Protein of unknown function (DUF328)) b0006(Peroxide resistance protein, lowers intracellular iron) BN373_04881(conserved hypothetical protein) t0005(conserved hypothetical protein) SL1344_0005(conserved hypothetical protein) Cluster1948 1 1 1 1 1 1 1 ROD_00031(threonine synthase) ENC_45280(L-threonine synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3991(Threonine synthase,threonine synthase,threonine synthase,Pyridoxal-phosphate dependent enzyme) b0004(threonine synthase) BN373_04861(threonine synthase) t0004(threonine synthase) SL1344_0004(threonine synthase) Cluster1949 1 1 1 1 1 1 1 ROD_00021(homoserine kinase) ENC_45270(homoserine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3992(Homoserine kinase,homoserine kinase,Archaeal shikimate kinase,homoserine kinase,GHMP kinases N terminal domain) b0003(homoserine kinase) BN373_04851(homoserine kinase) t0003(homoserine kinase) SL1344_0003(Homoserine kinase) Cluster1950 1 1 1 1 1 1 1 ROD_00011(bifunctional aspartokinase I/homoserine dehydrogenase I) ENC_45260(aspartate kinase /homoserine dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3993(Aspartokinase I/homoserine dehydrogenase I,bifunctional aspartokinase I/homoserine dehydrogenase I,Homoserine dehydrogenase,aspartate kinase,Homoserine dehydrogenase) b0002(fused aspartokinase I and homoserine dehydrogenase I) BN373_04841(aspartokinase/homoserine dehydrogenase I) t0002(aspartokinase I) SL1344_0002(aspartokinase I/homoserine dehydrogenase I) Cluster1951 1 1 1 1 1 1 1 ROD_50891(putative RNA methyltransferase) ENC_45240(RNA methyltransferase, TrmH family, group 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3995(Uncharacterized tRNA/rRNA methyltransferase HI_0380,putative RNA methyltransferase,RNA methyltransferase, TrmH family, group 1,SpoU rRNA Methylase family) b4403(predicted rRNA methyltransferase) BN373_04821(RNA methyltransferase, TrmH family, group 1) t4639(putative RNA methyltransferase) SL1344_4527(putative RNA methyltransferase) Cluster1952 1 1 1 1 1 1 1 ROD_50881(aerobic respiration control protein) ENC_45230(Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3996(Dye resistance protein,two-component response regulator,Response regulator containing a CheY-like receiver domain and an HD-GYP domain,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain) b4401(DNA-binding response regulator in two-component regulatory system with ArcB or CpxA) BN373_04811(aerobic respiration control protein ArcA) t4637(global response regulator) SL1344_4525(global response regulator) Cluster1953 1 1 1 1 1 1 1 ROD_50841(putative exported protein) ENC_45220(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4000(hypothetical protein,Uncharacterized protein conserved in bacteria,CreA protein) b4397(conserved protein) BN373_04771(creA protein) t4626(conserved hypothetical protein) SL1344_4514(expressed protein of unknown function) Cluster1954 1 1 1 1 1 1 1 ROD_50831(right origin-binding protein) ENC_45210(transcriptional regulator, AraC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4001(Right origin-binding protein,right oriC-binding transcriptional activator,DNA gyrase inhibitor,YSIRK-targeted surface antigen transcriptional regulator,Helix-turn-helix domain) b4396(right oriC-binding transcriptional activator, AraC family) BN373_04761(right origin-binding protein) t4625(right origin-binding protein) SL1344_4513(right origin-binding protein) Cluster1955 1 1 1 1 1 1 1 ROD_50821(phosphoglycerate mutase 2) ENC_45200(phosphoglycerate mutase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4002(Alpha-ribazole phosphatase,phosphoglycerate mutase,alpha-ribazole phosphatase,Histidine phosphatase superfamily (branch 1)) b4395(phosphatase) BN373_04751(phosphoglycerate mutase family protein) t4624(probable phosphoglycerate mutase 2) SL1344_4512(probable phosphoglycerate mutase 2) Cluster1956 1 1 1 1 1 1 1 ROD_50801(trp operon repressor) ENC_45180(Trp operon repressor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4004(Trp operon repressor,Trp operon repressor,Trp operon repressor,trp operon repressor,Trp repressor protein) b4393(DNA-binding transcriptional repressor, tryptophan-binding) BN373_04731(trp operon repressor) t4622(probable trp operon repressor) SL1344_4510(probable trp operon repressor) Cluster1957 1 1 1 1 1 1 1 ROD_49131(transcriptional regulator) ENC_45120(cytidyltransferase-related domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4007(Trifunctional NAD biosynthesis/regulator protein NadR,bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase,Predicted ATPase/kinase involved in NAD metabolism,nicotinamide-nucleotide adenylyltransferase,Helix-turn-helix) b4390(bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase) BN373_04701(nicotinamide-nucleotide adenylyltransferase) t4619(conserved hypothetical transcriptional regulator) SL1344_4507(conserved hypothetical transcriptional regulator) Cluster1958 1 1 1 1 1 1 1 ROD_49111(phosphoserine phosphatase) ENC_45100(phosphoserine phosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4009(Phosphoserine phosphatase,phosphoserine phosphatase,ACT domain-containing protein,phosphoserine phosphatase SerB,haloacid dehalogenase-like hydrolase) b4388(3-phosphoserine phosphatase) BN373_04681(phosphoserine phosphatase) t4617(putative phosphoserine phosphatase) SL1344_4505(putative phosphoserine phosphatase) Cluster1959 1 1 1 1 1 1 1 ROD_49101(putative exported protein) ENC_45090(Uncharacterized membrane protein affecting hemolysin expression) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4010(unknown domain/lipoate-protein ligase A fusion protein,Uncharacterized membrane protein affecting hemolysin expression,Bacterial virulence factor haemolysin) b4387(conserved membrane protein) BN373_04671(Smp protein) t4616(putative membrane protein) SL1344_4504(putative membrane protein) Cluster1960 1 1 1 1 1 1 1 ROD_49091(lipoate-protein ligase A) ENC_45080(lipoate-protein ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4011(Lipoate-protein ligase A,unknown domain/lipoate-protein ligase A fusion protein,Lipoate-protein ligase A,lipoyltransferase and lipoate-protein ligase,Biotin/lipoate A/B protein ligase family) b4386(lipoate-protein ligase A) BN373_04661(lipoate-protein ligase A) t4615(lipoate-protein ligase A) SL1344_4503(lipoate-protein ligase A) Cluster1961 1 1 1 1 1 1 1 ROD_49061(phosphopentomutase) ENC_45060(phosphopentomutase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4014(Phosphopentomutase,phosphopentomutase,Predicted phosphoglycerate mutase, AP superfamily,phosphopentomutase,Metalloenzyme superfamily) b4383(phosphopentomutase) BN373_04641(phosphopentomutase) t4612(phosphopentomutase) SL1344_4496(phosphopentomutase) Cluster1962 1 1 1 1 1 1 1 ROD_49051(thymidine phosphorylase) ENC_45050(thymidine phosphorylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4015(Thymidine phosphorylase,thymidine phosphorylase,Thymidine phosphorylase,thymidine phosphorylase,Glycosyl transferase family, a/b domain) b4382(thymidine phosphorylase) BN373_04631(thymidine phosphorylase) t4611(thymidine phosphorylase) SL1344_4495(thymidine phosphorylase) Cluster1963 1 1 1 1 1 1 1 ROD_49041(deoxyribose-phosphate aldolase) ENC_45040(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4016(Deoxyribose-phosphate aldolase,deoxyribose-phosphate aldolase,Deoxyribose-phosphate aldolase,deoxyribose-phosphate aldolase,DeoC/LacD family aldolase) b4381(2-deoxyribose-5-phosphate aldolase, NAD(P)-linked) BN373_04621(deoxyribose-phosphate aldolase) t4610(deoxyribose-phosphate aldolase) SL1344_4494(deoxyribose-phosphate aldolase) Cluster1964 1 1 1 1 1 1 1 ROD_48981(osmotically-inducible protein Y) ENC_44970(Predicted periplasmic or secreted lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4022(Osmotically-inducible protein Y precursor,periplasmic protein,Predicted periplasmic or secreted lipoprotein,BON domain) b4376(periplasmic protein) BN373_04571(osmotically-inducible protein Y) t4604(Putative periplasmic protein) SL1344_4489(Putative periplasmic protein) Cluster1965 1 1 1 1 1 1 1 ROD_48961(peptide chain release factor 3) ENC_44960(bacterial peptide chain release factor 3 (bRF-3)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4023(Peptide chain release factor 3,peptide chain release factor 3,GTPases - translation elongation factors,peptide chain release factor 3,Elongation factor Tu GTP binding domain) b4375(peptide chain release factor RF-3) BN373_04561(peptide chain release factor 3) t4603(peptide chain release factor 3) SL1344_4488(peptide chain release factor 3) Cluster1966 1 1 1 1 1 1 1 ROD_48741(ribosomal-protein-alanine acetyltransferase) ENC_44940([SSU ribosomal protein S18P]-alanine acetyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4025(N-acyltransferase YncA,ribosomal-protein-alanine N-acetyltransferase,Predicted acetyltransferase,ribosomal-protein-alanine acetyltransferase,Acetyltransferase (GNAT) family) b4373(ribosomal-protein-S18-alanine N-acetyltransferase) BN373_04541(ribosomal-protein-alanine acetyltransferase) t4601(ribosomal-protein-alanine acetyltransferase) SL1344_4486(ribosomal-protein-alanine acetyltransferase) Cluster1967 1 1 1 1 1 1 1 ROD_48721(ribosomal RNA small subunit methyltransferase C) ENC_44920(16S rRNA m(2)G 1207 methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4027(Ribosomal RNA small subunit methyltransferase C,16S ribosomal RNA m2G1207 methyltransferase,16S RNA G1207 methylase RsmC,protein-(glutamine-N5) methyltransferase, release factor-specific,Methyltransferase small domain N-terminal) b4371(16S rRNA m(2)G1207 methyltransferase) BN373_04521(ribosomal RNA small subunit methyltransferase C) t4599(conserved hypothetical protein) SL1344_4484(conserved hypothetical protein) Cluster1968 1 1 1 1 1 1 1 ROD_48711(putative membrane protein) ENC_44910(Protein of unknown function (DUF1435).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4031(Protein of unknown function (DUF1435)) b4567(predicted protein) BN373_04511(tryptophan-specific transport protein) t4595(conserved hypothetical protein) SL1344_4483(conserved hypothetical protein) Cluster1969 1 1 1 1 1 1 1 ROD_48691(ferric iron reductase protein) ENC_44890(Uncharacterized Fe-S protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4032(Ferric iron reductase protein fhuF,ferric iron reductase involved in ferric hydroximate transport,Uncharacterized Fe-S protein,siderophore-iron reductase FhuF,Ferric iron reductase FhuF-like transporter) b4367(ferric iron reductase involved in ferric hydroximate transport) BN373_04491(ferric iron reductase involved in ferric hydroximate transport) t4593(ferric iron reductase protein) SL1344_4481(ferric iron reductase protein) Cluster1970 1 1 1 1 1 1 1 ROD_48681(putative transcriptional regulator) ENC_44860(Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4033(Transcriptional activator protein BglJ,DNA-binding transcriptional activator BglJ,Response regulator,Bacterial regulatory proteins, luxR family) b4366(DNA-binding transcriptional activator for silent bgl operon, requires the bglJ4 allele to function; LuxR family) BN373_04461(transcriptional regulator, LuxR family) t4591(conserved hypothetical regulatory protein) SL1344_4479(conserved hypothetical regulatory protein) Cluster1971 1 1 1 1 1 1 1 ROD_48671(transcriptional regulator) ENC_44850(Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4034(Putative transcription factor YjjQ,DNA-binding transcriptional activator BglJ,Bacterial regulatory proteins, luxR family) b4365(DNA-binding transcriptional regulator) BN373_04451(transcriptional regulator, LuxR family) t4590(conserved hypothetical regulatory protein) SL1344_4478(conserved hypothetical regulatory protein) Cluster1972 1 1 1 1 1 1 1 ROD_48621(putative membrane protein) ENC_44830(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4036(hypothetical protein,hypothetical protein,Uncharacterized conserved protein,Protein of unknown function (DUF3815)) b4363(conserved inner membrane protein) BN373_04411(putative membrane protein) t4588(putative membrane protein) SL1344_4476(putative membrane protein) Cluster1973 1 1 1 1 1 1 1 ROD_48611(primosomal protein I) ENC_44800(primosomal protein I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4037(Primosomal protein I,primosomal protein DnaI,Pyocin large subunit) b4362(DNA biosynthesis protein (primosomal protein I)) BN373_04401(primosomal protein 1) t4587(primosomal protein I) SL1344_4475(primosomal protein I) Cluster1974 1 1 1 1 1 1 1 ROD_48601(DNA replication protein) ENC_44790(replicative DNA helicase loader DnaC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4038(DNA replication protein dnaC,DNA replication protein DnaC,DNA replication protein,chromosomal replication initiator protein DnaA,IstB-like ATP binding protein) b4361(DNA biosynthesis protein) BN373_04391(DNA replication protein DnaC) t4586(probable DNA replication protein) SL1344_4474(probable DNA replication protein) Cluster1975 1 1 1 1 1 1 1 ROD_48591(putative glycoprotein/receptor) ENC_44780(Protein of unknown function (DUF2501).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4039(hypothetical protein,Protein of unknown function (DUF2501)) b4360(conserved protein) BN373_04381(conserved hypothetical protein) t4585(putative secreted protein) SL1344_4473(putative secreted protein) Cluster1976 1 1 1 1 1 1 1 ROD_48361(conserved hypothetical protein) ENC_44600(Uncharacterized small protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4046(Uncharacterized small protein,Protein of unknown function (DUF466)) b4353(conserved protein) BN373_04001(conserved hypothetical protein) t4581(conserved hypothetical protein) SL1344_4462(conserved hypothetical protein) Cluster1977 1 1 1 1 1 1 1 ROD_48351(putative nucleotide-binding protein) ENC_44590(Putative GTPases (G3E family)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4047(Uncharacterized GTP-binding protein YjiA,putative GTP-binding protein YjiA,cobalamin biosynthesis protein CobW,CobW/HypB/UreG, nucleotide-binding domain) b4352(predicted GTPase) BN373_03991(CobW/P47K family protein) t4580(conserved hypothetical protein) SL1344_4461(conserved hypothetical protein) Cluster1978 1 1 1 1 1 1 1 ROD_48251(putative membrane protein) ENC_44490(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4059(Predicted membrane protein,Protein of unknown function (DUF445)) b4336(zinc-type alcohol dehydrogenase-like protein) BN373_03931(putative membrane protein) t4567(putative membrane protein) SL1344_4447(putative membrane protein) Cluster1979 1 1 1 1 1 1 1 ROD_37331(conserved hypothetical protein) ENC_03080(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3298(hypothetical protein,Uncharacterized conserved protein,Protein of unknown function (DUF1722)) b0707(conserved protein, DUF1722 family) BN373_03491(conserved hypothetical protein) t1257(putative pathogenicity island protein) SL1344_1323(putative pathogenicity island protein) Cluster1980 1 1 1 1 1 1 1 ROD_33281(putative permease) ENC_34480(Predicted permeases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4189(Lipopolysaccharide export system permease protein lptG,lipopolysaccharide ABC transporter permease,Predicted permeases,Predicted permease YjgP/YjgQ family) b4262(lipopolysaccharide export ABC permease of the LptBFGC export complex) BN373_02841(putative permease) t4514(putative inner membrane protein) SL1344_4410(putative inner membrane protein) Cluster1981 1 1 1 1 1 1 1 ROD_33261(cytosol aminopeptidase) ENC_34500(aminopeptidase A. Metallo peptidase. MEROPS family M17) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4191(Cytosol aminopeptidase,multifunctional aminopeptidase A,Cytosol aminopeptidase family, catalytic domain) b4260(multifunctional aminopeptidase A: a cyteinylglycinase, transcription regulator and site-specific recombination factor) BN373_02821(leucyl aminopeptidase) t4512(cytosol aminopeptidase) SL1344_4407(cytosol aminopeptidase) Cluster1982 1 1 1 1 1 1 1 ROD_33251(DNA polymerase III, chi subunit) ENC_34510(DNA polymerase III, chi subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4192(DNA polymerase III subunit chi,DNA polymerase III subunit chi,DNA polymerase III chi subunit, HolC) b4259(DNA polymerase III, chi subunit) BN373_02811(DNA polymerase III, chi subunit) t4511(DNA polymerase III, chi subunit) SL1344_4406(DNA polymerase III, chi subunit) Cluster1983 1 1 1 1 1 1 1 ROD_33241(valyl-tRNA synthetase) ENC_34520(valyl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4193(Valine--tRNA ligase,valyl-tRNA synthetase,Valyl-tRNA synthetase,valine--tRNA ligase,tRNA synthetases class I (I, L, M and V)) b4258(valyl-tRNA synthetase) BN373_02801(valyl-tRNA synthetase) t4510(valyl-tRNA synthetase) SL1344_4405(valyl-tRNA synthetase) Cluster1984 1 1 1 1 1 1 1 ROD_33221(putative acetyltransferase) ENC_34540(N-acetylglutamate synthase and related acetyltransferases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4195(Predicted acetyltransferase,ribosomal-protein-alanine acetyltransferase,Acetyltransferase (GNAT) family) b4256(predicted acetyltransferase) BN373_02791(acetyltransferase, GNAT family) t4508(putative acetyltransferase) SL1344_4403(putative acetyltransferase) Cluster1985 1 1 1 1 1 1 1 ROD_33211(conserved hypothetical protein) ENC_43860(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4196(Regulator of ribonuclease activity B,RNase E inhibitor protein,Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF1260)) b4255(protein inhibitor of RNase E) BN373_02771(conserved hypothetical protein) t4504(conserved hypothetical protein) SL1344_4400(conserved hypothetical protein) Cluster1986 1 1 1 1 1 1 1 ROD_33191(conserved hypothetical protein) ENC_43790(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4200(Toxin-antitoxin biofilm protein TabA,uncharacterized protein, YhcH/YjgK/YiaL family,Domain of unknown function (DUF386)) b4252(biofilm modulator regulated by toxins) BN373_02691(conserved hypothetical protein) t4502(conserved hypothetical protein) SL1344_4398(conserved hypothetical protein) Cluster1987 1 1 1 1 1 1 1 ROD_33161(aspartate carbamoyltransferase catalytic subunit) ENC_43730(aspartate carbamoyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4204(Aspartate carbamoyltransferase catalytic chain,aspartate carbamoyltransferase catalytic subunit,Aspartate carbamoyltransferase, catalytic chain,aspartate carbamoyltransferase,Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain) b4245(aspartate carbamoyltransferase, catalytic subunit) BN373_02681(aspartate carbamoyltransferase, catalytic subunit) t4495(aspartate carbamoyltransferase catalytic subunit) SL1344_4391(aspartate carbamoyltransferase catalytic subunit) Cluster1988 1 1 1 1 1 1 1 ROD_33151(aspartate carbamoyltransferase regulatory subunit) ENC_43720(aspartate carbamoyltransferase, regulatory subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4205(Aspartate carbamoyltransferase regulatory chain,aspartate carbamoyltransferase regulatory subunit,aspartate carbamoyltransferase, regulatory subunit,Aspartate carbamoyltransferase regulatory chain, allosteric domain) b4244(aspartate carbamoyltransferase, regulatory subunit) BN373_02671(aspartate carbamoyltransferase, regulatory subunit) t4494(aspartate carbamoyltransferase regulatory subunit) SL1344_4390(aspartate carbamoyltransferase regulatory subunit) Cluster1989 1 1 1 1 1 1 1 ROD_33141(putative endoribonuclease) ENC_43710(endoribonuclease L-PSP, putative) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4206(Enamine/imine deaminase,putative endoribonuclease L-PSP,putative endoribonuclease L-PSP,Endoribonuclease L-PSP) b4243(conserved protein, UPF0131 family) BN373_02661(putative endoribonuclease L-PSP) t4493(conserved hypothetical protein) SL1344_4389(conserved hypothetical protein) Cluster1990 1 1 1 1 1 1 1 ROD_33121(trehalose operon repressor) ENC_43670(transcriptional regulator, LacI family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4209(Trehalose operon repressor,trehalose repressor,ABC-type sugar transport system, periplasmic component,trehalose operon repressor,Bacterial regulatory proteins, lacI family) b4241(DNA-binding transcriptional repressor) BN373_02641(trehalose operon repressor) t4490(trehalose operon repressor) SL1344_4386(trehalose operon repressor) Cluster1991 1 1 1 1 1 1 1 ROD_33111(trehalose-specific PTS system EIIBC component) ENC_43660(PTS system trehalose-specific IIB component, Glc family (TC 4.A.1.2.4)/PTS system trehalose-specific IIC component, Glc family (TC 4.A.1.2.4)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4210(EIIBC-Tre,PTS system trehalose(maltose)-specific transporter subunits IIBC,PTS system, trehalose-specific IIBC component,Phosphotransferase system, EIIC) b4240(fused trehalose(maltose)-specific PTS enzyme: IIB component/IIC component) BN373_02631(PTS system, trehalose-specific IIBC component) t4489(trehalose-specific IIBC component of PTS system) pseudoSL1344_4385(PTS system, trehalose-specific IIBC component (pseudogene)) Cluster1992 1 1 1 1 1 1 1 ROD_33101(trehalose-6-phosphate hydrolase) ENC_43650(alpha,alpha-phosphotrehalase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4211(Trehalose-6-phosphate hydrolase,trehalose-6-phosphate hydrolase,Maltooligosyl trehalose synthase,alpha,alpha-phosphotrehalase,Alpha amylase, catalytic domain) b4239(trehalose-6-P hydrolase) BN373_02621(alpha,alpha-phosphotrehalase) t4488(trehalose-6-phosphate hydrolase) SL1344_4384(trehalose-6-phosphate hydrolase) Cluster1993 1 1 1 1 1 1 1 ROD_33091(anaerobic ribonucleoside-triphosphate reductase) ENC_43570(anaerobic ribonucleoside-triphosphate reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4212(Anaerobic ribonucleoside-triphosphate reductase,anaerobic ribonucleoside triphosphate reductase,anaerobic ribonucleoside-triphosphate reductase,Glycine radical) b4238(anaerobic ribonucleoside-triphosphate reductase) BN373_02561(anaerobic ribonucleoside-triphosphate reductase) t4486(anaerobic ribonucleoside-triphosphate reductase) SL1344_4382(anaerobic ribonucleoside-triphosphate reductase) Cluster1994 1 1 1 1 1 1 1 ROD_33081(anaerobic ribonucleoside-triphosphate reductase activating protein) ENC_43560(ribonucleoside-triphosphate reductase class III activase subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4213(Pyruvate formate-lyase 1-activating enzyme,anaerobic ribonucleotide reductase-activating protein,anaerobic ribonucleoside-triphosphate reductase activating protein) b4237(anaerobic ribonucleotide reductase activating protein) BN373_02551(anaerobic ribonucleoside-triphosphate reductase activating protein) t4485(anaerobic ribonucleoside-triphosphate reductase activating protein) SL1344_4381(anaerobic ribonucleoside-triphosphate reductase activating protein) Cluster1995 1 1 1 1 1 1 1 ROD_32961(putative modulator of DNA gyrase) ENC_43430(microcin-processing peptidase 1. Unknown type peptidase. MEROPS family U62) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4215(hypothetical protein,peptidase PmbA,Predicted Zn-dependent proteases and their inactivated homologs,Putative modulator of DNA gyrase) b4235(predicted peptidase required for the maturation and secretion of the antibiotic peptide MccB17) BN373_02421(protein PmbA) t4472(putative PmbA protein) SL1344_4368(putative PmbA protein) Cluster1996 1 1 1 1 1 1 1 ROD_32951(conserved hypothetical protein) ENC_43420(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4216(x96 protein,hypothetical protein,Protein of unknown function (DUF615)) b4234(conserved protein, ribosome-associated) BN373_02411(conserved hypothetical protein) t4471(conserved hypothetical protein) SL1344_4367(conserved hypothetical protein) Cluster1997 1 1 1 1 1 1 1 ROD_32941(murein peptide ligase) ENC_43410(UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diamino pimelate ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4217(UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-me so-diaminopimelate ligase,UDP-N-acetylmuramate--L-alanine ligase,Folylpolyglutamate synthase,UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes o-diaminopimelate ligase,Mur ligase middle domain) b4233(UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase) BN373_02381(UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-me so-diaminopimelate ligase) t4470(murein peptide ligase) SL1344_4349(murein peptide ligase) Cluster1998 1 1 1 1 1 1 1 ROD_32931(fructose-1,6-bisphosphatase) ENC_43400(D-fructose 1,6-bisphosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4218(Fructose-1,6-bisphosphatase class 1,fructose-1,6-bisphosphatase,Fructose-1-6-bisphosphatase) b4232(fructose-1,6-bisphosphatase I) BN373_02371(fructose-bisphosphatase) t4469(fructose-1,6-bisphosphatase) SL1344_4348(fructose-1,6-bisphosphatase) Cluster1999 1 1 1 1 1 1 1 ROD_32861(inorganic pyrophosphatase) ENC_43340(Inorganic pyrophosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4223(Inorganic pyrophosphatase,inorganic pyrophosphatase,Inorganic pyrophosphatase,Inorganic pyrophosphatase) b4226(inorganic pyrophosphatase) BN373_02321(inorganic diphosphatase) t4468(inorganic pyrophosphatase) SL1344_4347(inorganic pyrophosphatase) Cluster2000 1 1 1 1 1 1 1 ROD_32831(conserved hypothetical protein) ENC_43330(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4226(Gamma-glutamylcyclotransferase family protein ytfP,AIG2-like family) b4222(conserved protein, UPF0131 family) BN373_02281(conserved hypothetical protein) t4465(conserved hypothetical protein) SL1344_4344(conserved hypothetical protein) Cluster2001 1 1 1 1 1 1 1 ROD_32821(putative exported protein) ENC_43310(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4227(hypothetical protein,Family of unknown function (DUF490)) b4221(large conserved protein, DUF490 family) BN373_02271(conserved hypothetical protein) t4464(putative exported protein) SL1344_4343(putative exported protein) Cluster2002 1 1 1 1 1 1 1 ROD_32811(putative outer membrane protein assembly factor) ENC_43300(Outer membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4228(hypothetical protein,outer membrane protein assembly factor YaeT,Outer membrane protein/protective antigen OMA87,outer membrane protein assembly complex, YaeT protein,Surface antigen) b4220(predicted outer membrane protein and surface antigen) BN373_02261(outer membrane protein, OMP85 family) t4463(putative exported protein) SL1344_4342(putative exported protein) Cluster2003 1 1 1 1 1 1 1 ROD_32801(peptide methionine sulfoxide reductase) ENC_43290(methionine-S-sulfoxide reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4229(Peptide methionine sulfoxide reductase MsrA,methionine sulfoxide reductase A,peptide-methionine (S)-S-oxide reductase,Peptide methionine sulfoxide reductase) b4219(methionine sulfoxide reductase A) BN373_02251(methionine-S-sulfoxide reductase) t4462(peptide methionine sulfoxide reductase) SL1344_4341(peptide methionine sulfoxide reductase) Cluster2004 1 1 1 1 1 1 1 ROD_32721(putative transporter) ENC_43200(Hemolysins and related proteins containing CBS domains) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4231(hypothetical protein,hypothetical protein,Putative Mg2+ and Co2+ transporter CorB,gliding motility-associated protein GldE,Domain of unknown function DUF21) b4218(inner membrane protein, UPF0053 family) BN373_02241(putative transporter) t4461(putative membrane protein) SL1344_4340(putative membrane protein) Cluster2005 1 1 1 1 1 1 1 ROD_32711(conserved hypothetical protein) ENC_43190(Protein of unknown function (DUF1107).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4232(Protein of unknown function (DUF1107)) b4217(conserved protein, DUF1107 family) BN373_02201(conserved hypothetical protein) t4459(conserved hypothetical protein) SL1344_4339(conserved hypothetical protein) Cluster2006 1 1 1 1 1 1 1 ROD_32701(putative exported protein) ENC_43180(conserved hypothetical protein YtfJ-family, TIGR01626) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4233(hypothetical protein,Predicted transcriptional regulator,conserved hypothetical protein YtfJ-family,,Bacterial protein of unknown function (YtfJ_HI0045)) b4216(predicted transcriptional regulator) BN373_02191(conserved hypothetical protein) t4458(putative exported protein) SL1344_4338(putative exported protein) Cluster2007 1 1 1 1 1 1 1 ROD_32691(cysQ protein) ENC_43170(3'(2'),5'-bisphosphate nucleotidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4234(3'(2'),5'-bisphosphate nucleotidase CysQ,adenosine-3'(2'),5'-bisphosphate nucleotidase,3'(2'),5'-bisphosphate nucleotidase,Inositol monophosphatase family) b4214(PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase) BN373_02181(3'(2'),5'-bisphosphate nucleotidase) t4457(CysQ protein) SL1344_4337(cysQ protein) Cluster2008 1 1 1 1 1 1 1 ROD_32671(conserved hypothetical protein) ENC_43140(Predicted transcriptional regulators) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4236(HTH-type transcriptional activator hxlR,HxlR-like helix-turn-helix) b4212(predicted transcriptional regulator, HxlR-type, DUF24 family) BN373_02161(putative transcriptional regulator) t4455(conserved hypothetical protein) SL1344_4335(conserved hypothetical protein) Cluster2009 1 1 1 1 1 1 1 ROD_32661(conserved hypothetical protein) ENC_43130(Predicted nucleoside-diphosphate-sugar epimerases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4237(Quinone oxidoreductase 2,Putative NADH-flavin reductase,ergot alkaloid biosynthesis protein, AFUA_2G17970 family,NmrA-like family) b4211(NAD(P)H:quinone oxidoreductase) BN373_02151(NmrA family protein) t4454(conserved hypothetical protein) SL1344_4334(conserved hypothetical protein) Cluster2010 1 1 1 1 1 1 1 ROD_32651(putative membrane protein) ENC_43110(Permeases of the drug/metabolite transporter (DMT) superfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4238(Inner membrane protein ytfF,Predicted permease, DMT superfamily,carboxylate/amino acid/amine transporter,EamA-like transporter family) b4210(inner membrane protein, DMT transporter family) BN373_02131(putative membrane protein) t4453(putative membrane protein) SL1344_4333(putative membrane protein) Cluster2011 1 1 1 1 1 1 1 ROD_32631(regulator of cell morphogenesis and NO signaling) ENC_43090(iron-sulfur cluster repair di-iron protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4239(Regulator of cell morphogenesis and NO signaling,iron-sulfur cluster repair di-iron protein,Uncharacterized conserved protein,iron-sulfur cluster repair di-iron protein,Domain of Unknown function (DUF542)) b4209(iron-sulfur cluster repair protein RIC) BN373_02121(regulator of cell morphogenesis and NO signaling) t4452(conserved hypothetical protein) SL1344_4332(conserved hypothetical protein) Cluster2012 1 1 1 1 1 1 1 ROD_32621(D-serine/D-alanine/glycine transporter) ENC_43080(Gamma-aminobutyrate permease and related permeases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4240(D-serine/D-alanine/glycine transporter,D-alanine/D-serine/glycine permease,Amino acid transporters,GABA permease,Amino acid permease) b4208(D-alanine/D-serine/glycine transporter) BN373_02111(D-serine/D-alanine/glycine transporter) t4449(D-serine/D-alanine/glycine transporter) SL1344_4331(D-serine/D-alanine/glycine transporter) Cluster2013 1 1 1 1 1 1 1 ROD_32611(probable FkbP-type 22 kDa peptidyl-prolyl cis-trans isomerase) ENC_43070(FKBP-type peptidyl-prolyl cis-trans isomerases 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4241(FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase,peptidyl-prolyl cis-trans isomerase,ABC-type uncharacterized transport system, permease component,FKBP-type peptidyl-prolyl cis-trans isomerase) b4207(FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase)) BN373_02101(FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase FklB) t4448(probable FkbP-type peptidyl-prolyl cis-trans isomerase) SL1344_4330(probable FkbP-type peptidyl-prolyl cis-trans isomerase) Cluster2014 1 1 1 1 1 1 1 ROD_32601(putative exported protein) ENC_43060(Cell envelope opacity-associated protein A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4242(Opacity-associated protein A LysM-like domain) b4206(predicted cell envelope opacity-associated protein) BN373_02091(opacity-associated family protein) t4447(conserved hypothetical protein) SL1344_4329(conserved hypothetical protein) Cluster2015 1 1 1 1 1 1 1 ROD_32581(50S ribosomal subunit protein L9) ENC_43030(LSU ribosomal protein L9P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4253(50S ribosomal protein L9,50S ribosomal protein L9,Ribosomal protein L9,ribosomal protein L9,Ribosomal protein L9, C-terminal domain) b4203(50S ribosomal subunit protein L9) BN373_02081(ribosomal protein L9) t4445(50S ribosomal subunit protein L9) SL1344_4327(50s ribosomal subunit protein L9) Cluster2016 1 1 1 1 1 1 1 ROD_32571(30S ribosomal subunit protein S18) ENC_43020(ribosomal protein S18) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4254(30S ribosomal protein S18,30S ribosomal protein S18,Ribosomal protein S18,ribosomal protein S18,Ribosomal protein S18) b4202(30S ribosomal subunit protein S18) BN373_02071(ribosomal protein S18) t4444(30s ribosomal subunit protein S18) SL1344_4326(30s ribosomal subunit protein S18) Cluster2017 1 1 1 1 1 1 1 ROD_32552(primosomal replication protein N) ENC_43010(restart primosome assembly protein PriB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4255(Primosomal replication protein n,primosomal replication protein N,Single-strand binding protein family) b4201(primosomal protein N) BN373_02061(primosomal replication protein N) t4443(primosomal replication protein N) SL1344_4325(primosomal replication protein N) Cluster2018 1 1 1 1 1 1 1 ROD_32551(30S ribosomal subunit protein S6) ENC_43000(ribosomal protein S6) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4256(30S ribosomal protein S6,30S ribosomal protein S6,ribosomal protein S6,Ribosomal protein S6) b4200(30S ribosomal subunit protein S6) BN373_02051(ribosomal protein S6) t4442(30s ribosomal protein S6) SL1344_4324(30s ribosomal protein S6) Cluster2019 1 1 1 1 1 1 1 ROD_32531(putative exported protein) ENC_42980(Protein of unknown function (DUF1471).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4257(Protein of unknown function (DUF1471)) b4199(predicted protein) BN373_02041(conserved hypothetical protein) t4440(conserved hypothetical protein) SL1344_4322(conserved hypothetical protein) Cluster2020 1 1 1 1 1 1 1 ROD_32511(L-ribulose-5-phosphate 3-epimerase (L-ascorbate utilization protein E)) ENC_42950(L-xylulose 5-phosphate 3-epimerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4259(L-ribulose-5-phosphate 3-epimerase ulaE,L-xylulose 5-phosphate 3-epimerase,Hydroxypyruvate isomerase,putative hexulose-6-phosphate isomerase,Xylose isomerase-like TIM barrel) b4197(L-xylulose 5-phosphate 3-epimerase) BN373_02011(L-ribulose-5-phosphate 3-epimerase) t4438(conserved hypothetical protein) SL1344_4320(L-ribulose 5-phosphate epimerase) Cluster2021 1 1 1 1 1 1 1 ROD_32501(3-keto-L-gulonate-6-phosphate decarboxylase (L-ascorbate utilization protein D)) ENC_42940(3-keto-L-gulonate 6-phosphate decarboxylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4260(3-keto-L-gulonate-6-phosphate decarboxylase ulaD,3-keto-L-gulonate-6-phosphate decarboxylase,Orotidine-5'-phosphate decarboxylase,3-hexulose-6-phosphate synthase,Orotidine 5'-phosphate decarboxylase / HUMPS family) b4196(3-keto-L-gulonate 6-phosphate decarboxylase) BN373_02001(3-dehydro-L-gulonate-6-phosphate decarboxylase) t4437(putative hexulose-6-phosphate synthase) SL1344_4319(putative hexulose-6-phosphate synthase) Cluster2022 1 1 1 1 1 1 1 ROD_32491(ascorbate-specific PTS system EIIA component) ENC_42930(PTS system ascorbate-specific IIA component, L-Asc family (TC 4.A.7.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4261(Ascorbate-specific phosphotransferase enzyme IIA component,PTS system L-ascorbate-specific transporter subunit IIA,Phosphotransferase system, galactitol-specific IIB component,PTS system, fructose subfamily, IIA component,Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2) b4195(L-ascorbate-specific enzyme IIA component of PTS) BN373_01991(ascorbate-specific phosphotransferase enzyme IIA component) t4436(probable sugar phosphotransferase) SL1344_4318(probable sugar phosphotransferase) Cluster2023 1 1 1 1 1 1 1 ROD_32481(ascorbate-specific PTS system EIIB component) ENC_42920(PTS system ascorbate-specific IIB component, L-Asc family (TC 4.A.7.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4262(Ascorbate-specific phosphotransferase enzyme IIB component,PTS system L-ascorbate-specific transporter subunit IIB,Phosphotransferase system, galactitol-specific IIB component,PTS system, Lactose/Cellobiose specific IIB subunit) b4194(L-ascorbate-specific enzyme IIB component of PTS) BN373_01981(ascorbate-specific phosphotransferase enzyme IIB component) t4435(putative IIB protein of PTS system) SL1344_4317(putative PTS system IIB protein) Cluster2024 1 1 1 1 1 1 1 ROD_32471(ascorbate-specific PTS system EIIC component) ENC_42910(PTS system ascorbate-specific IIC component, L-Asc family (TC 4.A.7.1.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4263(Ascorbate-specific PTS system EIIC component,PTS system ascorbate-specific transporter subunits IICB,Phosphotransferase system, galactitol-specific IIB component,PTS system sugar-specific permease component) b4193(L-ascorbate-specific enzyme IIC component of PTS) BN373_01971(ascorbate-specific permease IIC component) t4434(putative transport protein SgaT) SL1344_4316(putative transport protein SgaT) Cluster2025 1 1 1 1 1 1 1 ROD_32461(probable L-ascorbate-6-phosphate lactonase (L ascorbate utilization protein G)) ENC_42900(L-ascorbate 6-phosphate lactonase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4264(Probable L-ascorbate-6-phosphate lactonase ulaG,putative L-ascorbate 6-phosphate lactonase,Beta-lactamase superfamily domain) b4192(L-ascorbate 6-phosphate lactonase) BN373_01951(putative L-ascorbate-6-phosphate lactonase ulaG) t4433(conserved hypothetical protein) SL1344_4315(conserved hypothetical protein) Cluster2026 1 1 1 1 1 1 1 ROD_32451(DeoR-family transcriptional regulator) ENC_42890(Transcriptional regulators of sugar metabolism) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4265(HTH-type transcriptional regulator ulaR,transcriptional repressor UlaR,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,Bacterial regulatory proteins, deoR family) b4191(transcriptional tepressor for the L-ascorbate utilization (ula) divergon) BN373_01941(transcriptional regulator UlaR) t4432(probable transcriptional regulator) SL1344_4314(probable transcriptional regulator) Cluster2027 1 1 1 1 1 1 1 ROD_32441(putative esterase) ENC_42880(Prolyl oligopeptidase family.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4266(esterase,Predicted esterase,2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase,Alpha/beta hydrolase family) b4190(acyl CoA esterase actviity in vitro) BN373_01931(phospholipase/carboxylesterase) t4431(conserved hypothetical protein) SL1344_4313(conserved hypothetical protein) Cluster2028 1 1 1 1 1 1 1 ROD_32411(probable acyl CoA dehydrogenase) ENC_42830(Acyl-CoA dehydrogenases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4269(Putative acyl-CoA dehydrogenase AidB,isovaleryl CoA dehydrogenase,cyclohexanecarboxyl-CoA dehydrogenase,Acyl-CoA dehydrogenase, C-terminal domain) b4187(isovaleryl CoA dehydrogenase) BN373_01901(acyl-CoA dehydrogenase family protein) t4428(probable acyl Co-A dehydrogenase) SL1344_4310(probable acyl Co-A dehydrogenase) Cluster2029 1 1 1 1 1 1 1 ROD_32401(23S rRNA (guanosine-2'-O-)-methyltransferase) ENC_42810(23S rRNA Gm-2251 2'-O-methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4276(23S rRNA (guanosine-2'-O-)-methyltransferase RlmB,23S rRNA (guanosine-2'-O-)-methyltransferase,RNA methyltransferase, TrmH family, group 3,SpoU rRNA Methylase family) b4180(23S rRNA (Gm2251)-methyltransferase) BN373_01891(RNA methyltransferase, TrmH family, group 3) t4420(probable tRNA/rRNA methyltransferase) SL1344_4302(probable tRNA/rRNA methyltransferase) Cluster2030 1 1 1 1 1 1 1 ROD_32391(ribonuclease R) ENC_42800(RNAse R) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4277(Ribonuclease R,exoribonuclease R,Exoribonuclease II,VacB and RNase II family 3'-5' exoribonucleases,RNB domain) b4179(exoribonuclease R, RNase R) BN373_01881(ribonuclease R) t4419(ribonuclease R) SL1344_4301(ribonuclease R (RNase R)) Cluster2031 1 1 1 1 1 1 1 ROD_32381(transcriptional repressor) ENC_09910(rrf2 family protein (putative transcriptional regulator)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4278(HTH-type transcriptional repressor NsrR,transcriptional repressor NsrR,Rrf2 family protein,Transcriptional regulator) b4178(nitric oxide-sensitive repressor for NO regulon) BN373_01871(transcriptional repressor NsrR) t4418(conserved hypothetical protein) SL1344_4300(conserved hypothetical protein) Cluster2032 1 1 1 1 1 1 1 ROD_32371(adenylosuccinate synthetase) ENC_42780(Adenylosuccinate synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4279(Adenylosuccinate synthetase,adenylosuccinate synthetase,adenylosuccinate synthase,Adenylosuccinate synthetase) b4177(adenylosuccinate synthetase) BN373_01861(adenylosuccinate synthetase) t4417(adenylosuccinate synthetase) SL1344_4299(adenylosuccinate synthetase) Cluster2033 1 1 1 1 1 1 1 ROD_32351(HflC protein) ENC_42760(protease FtsH subunit HflC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4281(Modulator of FtsH protease HflC,FtsH protease regulator HflC,Uncharacterized protein conserved in bacteria,HflC protein,SPFH domain / Band 7 family) b4175(modulator for HflB protease specific for phage lambda cII repressor) BN373_01831(HflC protein) t4415(HflC protein) SL1344_4298(HflC protein) Cluster2034 1 1 1 1 1 1 1 ROD_32341(HflK protein) ENC_42750(protease FtsH subunit HflK) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4282(Modulator of FtsH protease HflK,FtsH protease regulator HflK,HflK protein,SPFH domain / Band 7 family) b4174(modulator for HflB protease specific for phage lambda cII repressor) BN373_01821(HflK protein) t4414(HflK protein) SL1344_4297(HflK protein) Cluster2035 1 1 1 1 1 1 1 ROD_32311(tRNA delta-2-isopentenylpyrophosphate (IPP) transferase) ENC_42700(tRNA isopentenyltransferase (miaA)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4285(tRNA dimethylallyltransferase,tRNA delta(2)-isopentenylpyrophosphate transferase,tRNA dimethylallyltransferase,IPP transferase) b4171(delta(2)-isopentenylpyrophosphate tRNA-adenosine transferase) BN373_01791(tRNA delta(2)-isopentenylpyrophosphate transferase) t4411(tRNA delta-2-isopentenylpyrophosphate transferase) SL1344_4294(tRNA delta-2-isopentenylpyrophosphate (IPP) transferase) Cluster2036 1 1 1 1 1 1 1 ROD_32301(DNA mismatch repair protein) ENC_42690(DNA mismatch repair protein MutL) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4286(DNA mismatch repair protein mutL,DNA mismatch repair protein,DNA mismatch repair enzyme (predicted ATPase),DNA mismatch repair protein MutL,DNA mismatch repair protein, C-terminal domain) b4170(methyl-directed mismatch repair protein) BN373_01781(DNA mismatch repair protein MutL) t4410(DNA mismatch repair protein) SL1344_4293(DNA mismatch repair protein) Cluster2037 1 1 1 1 1 1 1 ROD_32291(N-acetylmuramoyl-L-alanine amidase) ENC_42680(N-acetylmuramoyl-L-alanine amidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4287(N-acetylmuramoyl-L-alanine amidase AmiB precursor,N-acetylmuramoyl-l-alanine amidase II,N-acetylmuramoyl-L-alanine amidase CwlD,N-acetylmuramoyl-L-alanine amidase) b4169(N-acetylmuramoyl-l-alanine amidase II) BN373_01771(N-acetylmuramoyl-L-alanine amidase) t4409(N-acetylmuramoyl-L-alanine amidase) SL1344_4292(N-acetylmuramoyl-L-alanine amidase) Cluster2038 1 1 1 1 1 1 1 ROD_32281(putative hydrolase) ENC_42670(conserved hypothetical nucleotide-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4288(hypothetical protein,ADP-binding protein,ATPase, YjeE family,Uncharacterised P-loop hydrolase UPF0079) b4168(ADP-binding protein essential for nucleoid integrity) BN373_01761(conserved hypothetical protein TIGR00150) t4408(conserved hypothetical protein) SL1344_4291(conserved hypothetical protein) Cluster2039 1 1 1 1 1 1 1 ROD_32271(putative carbohydrate kinase) ENC_42660(yjeF C-terminal region, hydroxyethylthiazole kinase-related/yjeF N-terminal region) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4289(Nicotinamide nucleotide repair protein,putative carbohydrate kinase,Uncharacterized conserved protein,YjeF family C-terminal domain,Carbohydrate kinase) b4167(predicted carbohydrate kinase) BN373_01751(YjeF family protein) t4406(conserved hypothetical protein) SL1344_4290(conserved hypothetical protein) Cluster2040 1 1 1 1 1 1 1 ROD_32261(putative 4Fe-4S binding protein) ENC_42650(iron-sulfur cluster binding protein, putative) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4290(Epoxyqueuosine reductase,Methylated DNA-protein cysteine methyltransferase,putative iron-sulfur cluster-binding protein,Domain of unknown function (DUF1730)) b4166(epoxyqueuosine reductase, cobalamine-stimulated; queosine biosynthesis) BN373_01741(iron-sulfur cluster binding protein) t4407(putative 4Fe-4S binding protein) SL1344_4289(putative 4Fe-4S binding protein) Cluster2041 1 1 1 1 1 1 1 ROD_32241(oligoribonuclease) ENC_42640(Oligoribonuclease (3'->5' exoribonuclease)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4294(Oligoribonuclease,oligoribonuclease,Exonuclease) b4162(oligoribonuclease) BN373_01721(oligoribonuclease) t4402(oligoribonuclease) SL1344_4287(oligoribonuclease) Cluster2042 1 1 1 1 1 1 1 ROD_32221(phosphatidylserine decarboxylase proenzyme) ENC_42620(phosphatidylserine decarboxylase precursor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4296(Phosphatidylserine decarboxylase proenzyme,phosphatidylserine decarboxylase,Na+/alanine symporter,phosphatidylserine decarboxylase,Phosphatidylserine decarboxylase) b4160(phosphatidylserine decarboxylase) BN373_01701(phosphatidylserine decarboxylase) t4400(phosphatidylserine decarboxylase proenzyme) SL1344_4285(phosphatidylserine decarboxylase proenzyme) Cluster2043 1 1 1 1 1 1 1 ROD_32201(putative permease) ENC_42600(Amino acid transporters) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4299(Inner membrane transporter yjeM,inner membrane transporter YjeM,putative glutamate/gamma-aminobutyrate antiporter,Amino acid permease) b4156(predicted transporter) BN373_01681(amino acid permease family protein) t4397(putative amino acid permease) SL1344_4282(putative amino acid permease) Cluster2044 1 1 1 1 1 1 1 ROD_32191(putative lysyl-tRNA synthetase) ENC_42590(lysyl-tRNA synthetase-related protein GenX) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4300(hypothetical protein,poxB regulator PoxA,Aspartyl/asparaginyl-tRNA synthetases,EF-P lysine aminoacylase GenX,tRNA synthetases class II (D, K and N)) b4155(EF-P-lysine34-lysine ligase) BN373_01671(lysyl-tRNA synthetase homolog GenX) t4396(lysyl-tRNA synthetase) SL1344_4281(lysyl-tRNA synthetase) Cluster2045 1 1 1 1 1 1 1 ROD_32181(fumarate reductase flavoprotein subunit) ENC_42570(succinate dehydrogenase subunit A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4301(Fumarate reductase flavoprotein subunit,fumarate reductase flavoprotein subunit,Aspartate oxidase,fumarate reductase, flavoprotein subunit,FAD binding domain) b4154(fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit) BN373_01661(fumarate reductase, flavoprotein subunit) t4395(fumarate reductase, flavoprotein subunit) SL1344_4280(fumarate reductase, flavoprotein subunit) Cluster2046 1 1 1 1 1 1 1 ROD_32171(fumarate reductase iron-sulfur subunit) ENC_42560(succinate dehydrogenase subunit B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4302(Fumarate reductase iron-sulfur subunit,fumarate reductase iron-sulfur subunit,Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit,succinate dehydrogenase and fumarate reductase iron-sulfur protein) b4153(fumarate reductase (anaerobic), Fe-S subunit) BN373_01651(fumarate reductase, iron-sulfur protein) t4394(fumarate reductase, iron-sulfur protein) SL1344_4279(fumarate reductase, iron-sulfur protein) Cluster2047 1 1 1 1 1 1 1 ROD_32161(fumarate reductase subunit C) ENC_42550(Fumarate reductase subunit C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4303(Fumarate reductase 15 kDa hydrophobic protein,fumarate reductase subunit C,Fumarate reductase subunit C,Fumarate reductase subunit C) b4152(fumarate reductase (anaerobic), membrane anchor subunit) BN373_01641(fumarate reductase, cytochrome b subunit) t4393(fumarate reductase complex subunit C) SL1344_4278(fumarate reductase complex subunit C; membrane anchor polypeptide) Cluster2048 1 1 1 1 1 1 1 ROD_32131(quaternary ammonium compound-resistance protein SugE) ENC_42500(Membrane transporters of cations and cationic drugs) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4307(Quaternary ammonium compound-resistance protein sugE,multidrug efflux system protein,Membrane transporters of cations and cationic drugs,Small Multidrug Resistance protein) b4148(multidrug efflux system protein) BN373_01611(quaternary ammonium compound-resistance protein SugE) t4390(SugE protein) SL1344_4275(SugE protein) Cluster2049 1 1 1 1 1 1 1 ROD_32111(elongation factor P) ENC_42460(translation elongation factor P (EF-P)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4311(Elongation factor P,elongation factor P,translation elongation factor P,Elongation factor P, C-terminal) b4147(elongation factor EF-P) BN373_01581(translation elongation factor P) t4386(elongation factor P) SL1344_4271(elongation factor P) Cluster2050 1 1 1 1 1 1 1 ROD_32101(radical SAM superfamily protein) ENC_42450(L-lysine 2,3-aminomutase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4312(L-lysine 2,3-aminomutase,lysine-2,3-aminomutase-like protein,Radical SAM superfamily) b4146(EF-P lysylation protein; weak lysine 2,3-aminomutase) BN373_01571(KamA family protein) t4385(conserved hypothetical protein) SL1344_4270(conserved hypothetical protein) Cluster2051 1 1 1 1 1 1 1 ROD_32081(putative lipoprotein) ENC_42440(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4314(hypothetical protein) b4144(conserved protein) BN373_01461(putative lipoprotein) t4383(putative membrane protein) SL1344_4268(putative membrane protein) Cluster2052 1 1 1 1 1 1 1 ROD_32061(60 Kda chaperonin) ENC_42400(chaperonin GroL) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4315(hypothetical protein,chaperonin GroEL,chaperonin GroL,TCP-1/cpn60 chaperonin family) b4143(Cpn60 chaperonin GroEL, large subunit of GroESL) BN373_01451(chaperonin GroL) t4382(GroEL protein) SL1344_4267(GroEL protein) Cluster2053 1 1 1 1 1 1 1 ROD_32051(10 kda chaperonin (protein Cpn10) (groES protein)) ENC_42390(Co-chaperonin GroES (HSP10)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4316(hypothetical protein,co-chaperonin GroES,Chaperonin 10 Kd subunit) b4142(Cpn10 chaperonin GroES, small subunit of GroESL) BN373_01441(chaperonin GroS) t4381(GroES protein) SL1344_4266(GroES protein) Cluster2054 1 1 1 1 1 1 1 ROD_32031(protein FxsA (suppressor of F exclusion of phage T7)) ENC_42370(Protein affecting phage T7 exclusion by the F plasmid) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4318(Suppressor of F exclusion of phage T7,phage T7 F exclusion suppressor FxsA,Protein affecting phage T7 exclusion by the F plasmid,FxsA cytoplasmic membrane protein) b4140(suppressor of F exclusion of phage T7) BN373_01411(suppressor of F exclusion of phage T7) t4379(FxsA protein) SL1344_4264(FxsA protein) Cluster2055 1 1 1 1 1 1 1 ROD_32021(aspartate ammonia-lyase) ENC_42360(aspartate ammonia-lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4319(Aspartate ammonia-lyase,aspartate ammonia-lyase,Fumarase,aspartate ammonia-lyase,Lyase) b4139(aspartate ammonia-lyase) BN373_01401(aspartate ammonia-lyase) t4377(aspartate ammonia-lyase) SL1344_4263(aspartate ammonia-lyase) Cluster2056 1 1 1 1 1 1 1 ROD_32011(anaerobic C4-dicarboxylate transporter) ENC_42350(anaerobic c4-dicarboxylate membrane transporter family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4320(Anaerobic C4-dicarboxylate transporter DcuA,anaerobic C4-dicarboxylate transporter,Thiol:disulfide interchange protein,transporter, anaerobic C4-dicarboxylate uptake (Dcu) family,Anaerobic c4-dicarboxylate membrane transporter) b4138(C4-dicarboxylate antiporter) BN373_01391(anaerobic C4-dicarboxylate transporter DcuA) t4376(anaerobic C4-dicarboxylate transporter) SL1344_4262(anaerobic C4-dicarboxylate transporter) Cluster2057 2 0 0 0 5 0 0 ROD_19651(putative transposase A),pseudoROD_16541(putative transposase A (fragment)) BN373_01321(conserved hypothetical protein),BN373_11511(conserved hypothetical protein),BN373_23821(conserved hypothetical protein),BN373_28801(conserved hypothetical protein),BN373_31961(conserved hypothetical protein) Cluster2058 1 1 1 1 1 1 1 ROD_34811(proline/betaine transporter) ENC_05450(metabolite-proton symporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4355(Proline porter II,proline/glycine betaine transporter,Arabinose efflux permease,MFS transporter, metabolite:H+ symporter (MHS) family protein,Sugar (and other) transporter) b4111(proline/glycine betaine transporter) BN373_01151(proline/betaine transporter) t4197(ProP protein) SL1344_4227(putative amino acid permease) Cluster2059 1 1 1 1 1 1 1 ROD_34791(conserved hypothetical protein) ENC_05410(alkylphosphonate utilization operon protein PhnA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4358(hypothetical protein,putative alkylphosphonate utilization operon protein PhnA,PhnA protein) b4108(conserved protein) BN373_01141(alkylphosphonate utilization operon protein PhnA) t4196(conserved hypothetical protein) SL1344_4226(conserved hypothetical protein) Cluster2060 1 1 1 1 1 1 1 ROD_34661(putative exported protein) ENC_05070(Sel1 repeat.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4394(Sel1 repeat) b4078(conserved protein) BN373_00911(Sel1 repeat protein) t4191(putative exported protein) SL1344_4220(putative exported protein) Cluster2061 1 1 1 1 1 1 1 ROD_34651(proton glutamate symport protein) ENC_05060(Na+/H+-dicarboxylate symporters) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4395(Glutamate-aspartate carrier protein,glutamate/aspartate:proton symporter,Sodium:dicarboxylate symporter family) b4077(glutamate/aspartate:proton symporter) BN373_00901(proton glutamate symport protein) t4190(glutamate symport protein) SL1344_4219(proton glutamate symport protein) Cluster2062 1 1 1 1 1 1 1 ROD_34571(acetyl-coenzyme A synthetase) ENC_05050(acetyl-coenzyme A synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4403(Acetyl-coenzyme A synthetase,acetyl-CoA synthetase,Uncharacterized protein conserved in bacteria,acetate--CoA ligase,AMP-binding enzyme) b4069(acetyl-CoA synthetase) BN373_00881(acetate--CoA ligase) t4181(acetyl-coenzyme A synthetase) SL1344_4211(acetyl-coenzyme A synthetase) Cluster2063 1 1 1 1 1 1 1 ROD_34561(putative membrane protein) ENC_05040(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4404(Inner membrane protein yjcH,Protein of unknown function, DUF485) b4068(inner membrane protein, DUF485 family) BN373_00861(putative membrane protein) t4180(putative membrane protein) SL1344_4210(putative membrane protein) Cluster2064 1 1 1 1 1 1 1 ROD_34551(cation/acetate symporter) ENC_05030(cation/acetate symporter ActP) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4405(Acetate transporter ActP,acetate permease,Predicted symporter,cation/acetate symporter ActP,Sodium:solute symporter family) b4067(acetate transporter) BN373_00851(cation/acetate symporter ActP) t4179(Sodium:solute symporter family protein) SL1344_4209(Sodium:solute symporter family protein) Cluster2065 1 1 1 1 1 1 1 ROD_34511(putative sodium/hydrogen exchanger) ENC_04990(sodium/proton antiporter, CPA1 family (TC 2.A.36)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4409(Sodium, potassium, lithium and rubidium/H(+) antiporter,NhaP-type Na+/H+ and K+/H+ antiporters,Na+/H+ antiporter,Sodium/hydrogen exchanger family) b4065(predicted cation/proton antiporter) BN373_00751(Na+/H+ antiporter) t4175(putative sodium/hydrogen exchanger family protein) SL1344_4205(putative sodium/hydrogen exchanger family protein) Cluster2066 1 1 1 1 1 1 1 ROD_34471(AraC-family transcriptional regulator) ENC_04950(transcriptional regulator, AraC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4412(Regulatory protein soxS,DNA-binding transcriptional regulator SoxS,DNA gyrase inhibitor,YSIRK-targeted surface antigen transcriptional regulator,Helix-turn-helix domain) b4062(DNA-binding transcriptional dual regulator) BN373_00711(regulatory protein SoxS) t4171(regulatory protein SoxS) SL1344_4201(regulatory protein SoxS) Cluster2067 1 1 1 1 1 1 1 ROD_34461(putative signal transduction protein) ENC_04940(Predicted signal transduction protein containing sensor and EAL domains) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4413(Uncharacterized membrane protein YjcC,putative diguanylate cyclase,Predicted signal transduction protein containing sensor and EAL domains,EAL domain) b4061(predicted cyclic-di-GMP phosphodiesterase) BN373_00701(cyclic diguanylate phosphodiesterase (EAL) domain protein) t4170(putative exported protein) SL1344_4200(putative exported protein) Cluster2068 1 1 1 1 1 1 1 ROD_34441(putative membrane protein) ENC_04910(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4414(hypothetical protein) b4060(conserved protein) BN373_00691(putative membrane protein) t4169(putative membrane protein) SL1344_4199(putative membrane protein) Cluster2069 1 1 2 1 1 0 1 ROD_19641(enhancing lycopene biosynthesis protein 1) ENC_12770(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1816(Enhancing lycopene biosynthesis protein 1,anti-adapter protein IraM),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2556(Enhancing lycopene biosynthesis protein 1,anti-adapter protein IraM) b1160(RpoS stabilzer during Mg starvation, anti-RssB factor) BN373_00611(conserved hypothetical protein) SL1344_1049(conserved hypothetical protein) Cluster2070 1 1 1 1 1 1 1 ROD_36301(single-stranded binding protein) ENC_04900(single-strand binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4415(Helix-destabilizing protein,single-stranded DNA-binding protein,single-stranded DNA-binding protein,Single-strand binding protein family) b4059(single-stranded DNA-binding protein) BN373_00531(single-stranded DNA-binding protein) t4161(single-strand DNA-binding protein) SL1344_4192(single-strand DNA-binding protein) Cluster2071 1 1 1 1 1 1 1 ROD_36311(UvrABC system protein A (excinuclease ABC subunit A)) ENC_04890(Excinuclease ABC subunit A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4416(Excinuclease ABC subunit A,excinuclease ABC subunit A,Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component,excinuclease ABC subunit A,ABC transporter) b4058(ATPase and DNA damage recognition protein of nucleotide excision repair excinuclease UvrABC) BN373_00521(excinuclease ABC, A subunit) t4160(excision nuclease subunit A) SL1344_4190(excision nuclease subunit A) Cluster2072 1 1 1 1 1 1 1 ROD_36341(conserved hypothetical protein) ENC_04880(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4417(hypothetical protein,hypothetical protein,Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF419)) b4057(conserved protein) BN373_00511(conserved hypothetical protein) t4157(conserved hypothetical protein) SL1344_4187(conserved hypothetical protein) Cluster2073 1 1 1 1 1 1 1 ROD_36351(conserved hypothetical protein) ENC_04870(conserved hypothetical protein TIGR00149) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4418(Uncharacterized conserved protein,secondary thiamine-phosphate synthase enzyme,Uncharacterised protein family UPF0047) b4056(thiamin phosphate synthase) BN373_00501(conserved hypothetical protein TIGR00149) t4156(conserved hypothetical protein) SL1344_4186(conserved hypothetical protein) Cluster2074 1 1 1 1 1 1 1 ROD_36361(class B acid phosphatase) ENC_04860(HAD superfamily (subfamily IIIB) phosphatase, TIGR01672) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4419(Class B acid phosphatase precursor,acid phosphatase/phosphotransferase,Acid phosphatase (class B),HAD phosphatase, family IIIB,HAD superfamily, subfamily IIIB (Acid phosphatase)) b4055(acid phosphatase/phosphotransferase, class B, non-specific) BN373_00491(class B acid phosphatase) t4155(class B acid phosphatase precursor) SL1344_4185(class B acid phosphatase precursor) Cluster2075 1 0 1 1 2 1 1 ROD_36371(aromatic-amino-acid aminotransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4429(Aromatic-amino-acid aminotransferase,aromatic amino acid aminotransferase,threonine-phosphate decarboxylase,Aminotransferase class I and II) b4054(tyrosine aminotransferase, tyrosine-repressible, PLP-dependent) BN373_00481(aromatic-amino-acid transaminase),BN373_19861(putative aromatic-amino-acid transaminase) t4154(aromatic-amino-acid aminotransferase) SL1344_4184(aromatic-amino-acid aminotransferase) Cluster2076 1 1 1 1 1 1 1 ROD_36381(alanine racemase) ENC_04840(alanine racemase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4432(Alanine racemase, biosynthetic,alanine racemase,Uncharacterized protein conserved in bacteria,alanine racemase,Alanine racemase, N-terminal domain) b4053(alanine racemase 1, PLP-binding, biosynthetic) BN373_00471(alanine racemase) t4153(alanine racemase) SL1344_4183(alanine racemase) Cluster2077 1 1 1 1 1 1 1 ROD_36391(replicative DNA helicase protein DnaB) ENC_04830(replicative DNA helicase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4433(Replicative DNA helicase,replicative DNA helicase,Replicative DNA helicase,replicative DNA helicase,DnaB-like helicase C terminal domain) b4052(replicative DNA helicase) BN373_00461(replicative DNA helicase) t4152(replicative DNA helicase) SL1344_4182(replicative DNA helicase) Cluster2078 1 1 1 1 1 1 1 ROD_36401(quinone oxidoreductase) ENC_04820(NADPH:quinone reductase and related Zn-dependent oxidoreductases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4439(Quinone oxidoreductase 1,quinone oxidoreductase, NADPH-dependent,putative NAD(P)H quinone oxidoreductase, PIG3 family,Zinc-binding dehydrogenase) b4051(quinone oxidoreductase, NADPH-dependent) BN373_00451(quinone oxidoreductase) t4151(quinone oxidoreductase) SL1344_4181(quinone oxidoreductase) Cluster2079 1 1 1 1 1 1 1 ROD_36411(putative outer membrane protein) ENC_04810(phage shock protein G) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4440(Phage shock protein G,phage shock protein G,phage shock protein G,Phage shock protein G (Phageshock_PspG)) b4050(phage shock protein G) BN373_00441(phage shock protein G) t4150(putative membrane protein) SL1344_4180(putative membrane protein) Cluster2080 1 1 1 1 1 1 1 ROD_36421(putative tRNA-dihydrouridine synthase A) ENC_04800(tRNA-U16,U17-dihydrouridine synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4441(Probable tRNA-dihydrouridine synthase,tRNA-dihydrouridine synthase A,tRNA-dihydrouridine synthase,tRNA dihydrouridine synthase A,Dihydrouridine synthase (Dus)) b4049(tRNA-dihydrouridine synthase A) BN373_00431(tRNA-dihydrouridine synthase A) t4149(conserved hypothetical protein) SL1344_4179(conserved hypothetical protein) Cluster2081 1 1 1 1 1 1 1 ROD_37001(zinc uptake regulation protein) ENC_04770(zinc uptake regulator, Fur family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4442(Zinc uptake regulation protein,zinc uptake transcriptional repressor,Ferric uptake regulator family) b4046(DNA-binding transcriptional repressor, Zn(II)-binding) BN373_00411(zinc uptake regulation protein) t4147(zinc uptake regulation protein) SL1344_4177(zinc uptake regulation protein) Cluster2082 1 1 1 1 1 1 1 ROD_37011(putative stress response protein YjbJ) ENC_04760(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4443(hypothetical protein,hypothetical protein,CsbD-like) b4045(stress-induced protein, UPF0337 family) BN373_00401(CsbD family protein) t4146(conserved hypothetical protein) SL1344_4176(conserved hypothetical protein) Cluster2083 1 1 1 1 1 1 1 ROD_37021(DNA-damage-inducible protein F) ENC_04750(putative efflux protein, MATE family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4444(Multidrug export protein mepA,DNA-damage-inducible SOS response protein,MATE efflux family protein,MatE) b4044(DNA-damage-inducible SOS response protein) BN373_00391(DNA-damage-inducible protein F) t4144(putative DNA-damage-inducible membrane protein) SL1344_4175(putative DNA-damage-inducible membrane protein) Cluster2084 1 1 1 1 1 1 1 ROD_37031(LexA repressor) ENC_04740(SOS-response transcriptional repressor, LexA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4445(LexA repressor,LexA repressor,repressor LexA,LexA DNA binding domain) b4043(DNA-binding transcriptional repressor of SOS regulon) BN373_00381(LexA repressor) t4143(LexA repressor) SL1344_4174(LexA repressor) Cluster2085 1 1 1 1 1 1 1 ROD_37041(diacylglycerol kinase) ENC_04730(diacylglycerol kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4446(Diacylglycerol kinase,Prokaryotic diacylglycerol kinase) b4042(diacylglycerol kinase) BN373_00371(diacylglycerol kinase) t4142(diacylglycerol kinase) SL1344_4173(diacylglycerol kinase) Cluster2086 1 1 1 1 1 1 1 ROD_37051(glycerol-3-phosphate acyltransferase) ENC_04720(glycerol-3-phosphate acyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4447(Glycerol-3-phosphate acyltransferase,glycerol-3-phosphate acyltransferase,Glycerol-3-phosphate O-acyltransferase,glycerol-3-phosphate O-acyltransferase,Acyltransferase) b4041(glycerol-3-phosphate O-acyltransferase) BN373_00361(glycerol-3-phosphate acyltransferase) t4141(glycerol-3-phosphate acyltransferase) SL1344_4172(glycerol-3-phosphate acyltransferase) Cluster2087 1 1 1 1 1 1 1 ROD_37061(4-hydroxybenzoate octaprenyltransferase) ENC_04710(4-hydroxybenzoate octaprenyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4448(4-hydroxybenzoate octaprenyltransferase,4-hydroxybenzoate octaprenyltransferase,Polyprenyltransferase (cytochrome oxidase assembly factor),4-hydroxybenzoate polyprenyl transferase,UbiA prenyltransferase family) b4040(p-hydroxybenzoate octaprenyltransferase) BN373_00351(4-hydroxybenzoate polyprenyl transferase) t4140(4-hydroxybenzoate octaprenyl transferase) SL1344_4171(4-hydroxybenzoate octaprenyl transferase) Cluster2088 1 1 1 1 1 1 1 ROD_37071(chorismate--pyruvate lyase) ENC_04700(chorismate lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4449(Chorismate--pyruvate lyase,chorismate pyruvate lyase,4-hydroxybenzoate synthetase (chorismate lyase),Chorismate lyase) b4039(chorismate--pyruvate lyase) BN373_00341(chorismate lyase) t4139(chorismate lyase) SL1344_4170(chorismate lyase) Cluster2089 1 1 1 1 1 1 1 ROD_37081(maltose operon periplasmic protein) ENC_04670(Maltose operon periplasmic protein precursor (MalM).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4450(maltose regulon periplasmic protein,Maltose operon periplasmic protein precursor (MalM)) b4037(maltose regulon periplasmic protein) BN373_00331(maltose operon periplasmic protein) t4138(maltose operon periplasmic protein) SL1344_4169(maltose operon periplasmic protein) Cluster2090 1 1 1 1 1 1 1 ROD_37091(maltoporin (maltose-inducible porin)) ENC_04660(Maltoporin (phage lambda and maltose receptor)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4451(Maltose-inducible porin,maltoporin,Maltoporin (phage lambda and maltose receptor),LamB porin) b4036(maltose outer membrane porin (maltoporin)) BN373_00321(maltoporin) t4137(maltoporin precursor) SL1344_4168(maltoporin precursor) Cluster2091 1 1 1 1 1 1 1 ROD_37101(maltose/maltodextrin transport system, ATP-binding protein) ENC_04650(maltooligosaccharide ABC transporter ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4452(Maltose/maltodextrin import ATP-binding protein MalK,maltose/maltodextrin transporter ATP-binding protein,ABC-type spermidine/putrescine transport systems, ATPase components,putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein,ABC transporter) b4035(fused maltose transport subunit, ATP-binding component of ABC superfamily/regulatory protein) BN373_00311(maltose ABC transporter, ATP-binding protein MalK) t4136(maltose/maltodextrin transport ATP-binding protein) SL1344_4167(maltose/maltodextrin transport ATP-binding protein) Cluster2092 1 1 1 1 1 1 1 ROD_37111(maltose transport system, substrate-binding protein) ENC_04640(maltooligosaccharide-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4453(Maltodextrin-binding protein,maltose ABC transporter periplasmic protein,Maltose-binding periplasmic proteins/domains,carbohydrate ABC transporter substrate-binding protein, CPR_0540 family,Bacterial extracellular solute-binding protein) b4034(maltose transporter subunit) BN373_00301(maltose ABC transporter, periplasmic maltose-binding protein) t4135(periplasmic maltose-binding protein) SL1344_4166(periplasmic maltose-binding protein) Cluster2093 1 1 1 1 1 1 1 ROD_37121(maltose transport system, permease protein) ENC_04630(maltooligosaccharide ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4454(Maltose transport system permease protein malF,maltose transporter membrane protein,ABC-type polysaccharide transport system, permease component,NifC-like ABC-type porter,Binding-protein-dependent transport system inner membrane component) b4033(maltose transporter subunit) BN373_00291(maltose ABC transporter, permease protein MalF) t4134(maltose transport inner membrane protein) SL1344_4164(maltose transport inner membrane protein) Cluster2094 1 1 1 1 1 1 1 ROD_37131(maltose transport system, permease protein) ENC_04620(maltooligosaccharide ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4455(Maltose transport system permease protein malG,maltose transporter permease,ABC-type maltose transport systems, permease component,NifC-like ABC-type porter,Binding-protein-dependent transport system inner membrane component) b4032(maltose transporter subunit) BN373_00281(maltose ABC transporter, permease protein MalG) t4133(maltose transport inner membrane protein) SL1344_4163(maltose transport inner membrane protein) Cluster2095 1 1 1 1 1 1 1 ROD_37201(putative phosphate starvation-inducible membrane protein,protein psie) ENC_04610(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4456(hypothetical protein,phosphate-starvation-inducible protein PsiE,Predicted membrane protein,Phosphate-starvation-inducible E) b4030(phosphate starvation inducible protein) BN373_00271(phosphate-starvation-inducible protein PsiE) t4132(putative membrane protein) SL1344_4162(putative membrane protein) Cluster2096 1 1 1 1 1 1 1 ROD_47661(conserved hypothetical protein) ENC_33630(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.583(Serine dehydratase alpha chain) b4470(conserved protein) BN373_00261(conserved hypothetical protein) t3158(conserved hypothetical protein) SL1344_3210(conserved hypothetical protein) Cluster2097 1 1 1 1 1 1 1 ROD_37251(glucose-6-phosphate isomerase) ENC_04560(glucose-6-phosphate isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4463(Glucose-6-phosphate isomerase,glucose-6-phosphate isomerase,Phosphoglucose isomerase) b4025(glucosephosphate isomerase) BN373_00201(glucose-6-phosphate isomerase) t4127(glucose-6-phosphate isomerase) SL1344_4157(glucose-6-phosphate isomerase) Cluster2098 1 1 1 1 1 1 1 ROD_37261(lysine-sensitive aspartokinase III) ENC_04550(aspartate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4465(Lysine-sensitive aspartokinase 3,aspartate kinase III,Homoserine dehydrogenase,aspartate kinase, monofunctional class,Amino acid kinase family) b4024(aspartokinase III) BN373_00191(aspartokinase III, lysine-sensitive) t4126(lysine-sensitive aspartokinase III) SL1344_4156(lysine-sensitive aspartokinase III) Cluster2099 1 1 1 1 1 1 1 ROD_37311(conserved hypothetical protein) ENC_04530(Competence regulator Spx (YjbD).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4466(hypothetical protein,YjbD family (DUF3811)) b4023(conserved protein) BN373_00171(conserved hypothetical protein) t4121(conserved hypothetical protein) SL1344_4129(conserved hypothetical protein) Cluster2100 1 1 1 1 1 1 1 ROD_37321(ribosomal large subunit pseudouridine synthase F) ENC_04520(ribosomal large subunit pseudouridine synthase F) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4467(Ribosomal large subunit pseudouridine synthase F,23S rRNA pseudouridine synthase F,pseudouridine synthase,RNA pseudouridylate synthase) b4022(23S rRNA U2604 pseudouridine synthase) BN373_00161(ribosomal large subunit pseudouridine synthase F) t4120(putative pseudouridine synthase) SL1344_4128(putative pseudouridine synthase) Cluster2101 1 1 1 1 1 1 1 ROD_37361(putative transporter) ENC_04490(Na/Pi-cotransporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4476(sodium-dependent inorganic phosphate (Pi) transporter,Na+/Pi-cotransporter) b4020(predicted Na+/Pi-cotransporter) BN373_00071(sodium-dependent inorganic phosphate transporter) t4116(putative membrane protein) SL1344_4124(putative membrane protein) Cluster2102 1 1 1 1 1 1 1 ROD_37391(acetate operon repressor) ENC_04470(transcriptional regulator, IclR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4480(Acetate operon repressor,transcriptional repressor IclR,beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family,Bacterial transcriptional regulator) b4018(DNA-binding transcriptional repressor) BN373_00051(acetate operon repressor) t4114(acetate operon repressor) SL1344_4122(acetate operon repressor) Cluster2103 1 1 1 1 1 1 1 ROD_37411(isocitrate dehydrogenase kinase/phosphatase) ENC_04460(Isocitrate dehydrogenase kinase/phosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4481(Isocitrate dehydrogenase kinase/phosphatase,bifunctional isocitrate dehydrogenase kinase/phosphatase protein,Isocitrate dehydrogenase kinase/phosphatase (AceK)) b4016(isocitrate dehydrogenase kinase/phosphatase) BN373_00041(isocitrate dehydrogenase kinase/phosphatase) t4113(isocitrate dehydrogenase kinase/phosphatase) SL1344_4120(isocitrate dehydrogenase kinase/phosphatase) Cluster2104 1 1 1 1 1 1 1 ROD_37421(isocitrate lyase) ENC_04450(isocitrate lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4482(Isocitrate lyase,isocitrate lyase,Isocitrate lyase,isocitrate lyase,Isocitrate lyase family) b4015(isocitrate lyase) BN373_00031(isocitrate lyase) t4112(isocitrate lyase) SL1344_4119(isocitrate lyase) Cluster2105 1 1 1 1 1 1 1 ROD_37431(malate synthase A) ENC_04440(malate synthase A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4483(Malate synthase A,malate synthase,Isocitrate lyase,malate synthase A,Malate synthase) b4014(malate synthase A) BN373_00021(malate synthase A) t4111(malate synthase A) SL1344_4118(malate synthase A) Cluster2106 1 1 1 1 1 1 1 ROD_37451(putative acetyltransferase) ENC_02950(Acetyltransferases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4485(Uncharacterized N-acetyltransferase YjaB,putative acetyltransferase,ribosomal-protein-alanine acetyltransferase,Acetyltransferase (GNAT) family) b4012(predicted acetyltransferase) BN373_00001(acetyltransferase, GNAT family) t4109(putative acetyltransferase) SL1344_4116(putative acetyltransferase) Cluster2107 0 0 4 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.187(Streptomycin 3''-adenylyltransferase,aminoglycoside resistance protein,Predicted nucleotidyltransferases,Nucleotidyltransferase domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.25(Streptomycin 3''-adenylyltransferase,aminoglycoside resistance protein,Predicted nucleotidyltransferases,Nucleotidyltransferase domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.6(Streptomycin 3''-adenylyltransferase,aminoglycoside resistance protein,Predicted nucleotidyltransferases,Nucleotidyltransferase domain),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.7(Streptomycin 3''-adenylyltransferase,aminoglycoside resistance protein,Predicted nucleotidyltransferases,Nucleotidyltransferase domain) t1142(aminoglycoside-resistance protein) SL1344_1199(aminoglycoside-resistance protein) Cluster2108 0 0 4 0 0 2 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3873(Microcin-E7 immunity protein,Colicin immunity protein / pyocin immunity protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3874(Microcin-E7 immunity protein,Colicin immunity protein / pyocin immunity protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3875(Microcin-E7 immunity protein,Colicin immunity protein / pyocin immunity protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3876(Microcin-E7 immunity protein,Colicin immunity protein / pyocin immunity protein) t3036(bacteriocin immunity protein),t3038(bacteriocin immunity protein) Cluster2109 2 0 2 0 0 2 0 ROD_19861(putative phage tail protein),ROD_36531(putative phage tail protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3098(Phage tail protein E),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.7(Phage tail protein E) t2664(putative phage tail protein),t3440(putative phage tail protein) Cluster2110 1 0 2 0 0 1 2 ROD_36591(phage tail fibre assembly protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3092(Caudovirales tail fibre assembly protein),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.13(Caudovirales tail fibre assembly protein) t4304(putative phage tail fiber protein) SL1344_1929(putative bacteriophage tail protein),SL1344_2675(putative bacteriophage tail fibre protein) Cluster2111 1 0 5 0 0 0 0 pseudoROD_10851(putative IS21 family transposase (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1719(transposase/IS protein,DNA replication protein,chromosomal replication initiator protein DnaA,IstB-like ATP binding protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2525(transposase/IS protein,DNA replication protein,chromosomal replication initiator protein DnaA,IstB-like ATP binding protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4126(transposase/IS protein,DNA replication protein,chromosomal replication initiator protein DnaA,IstB-like ATP binding protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.938(transposase/IS protein,DNA replication protein,chromosomal replication initiator protein DnaA,IstB-like ATP binding protein),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.10(transposase/IS protein,DNA replication protein,chromosomal replication initiator protein DnaA,IstB-like ATP binding protein) Cluster2112 0 0 3 3 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1603(Transposase and inactivated derivatives,InsA C-terminal domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.757(Transposase and inactivated derivatives,InsA C-terminal domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.56(Transposase and inactivated derivatives,InsA C-terminal domain) b0265(IS1 repressor TnpA),b0275(IS1 repressor TnpA),b4516(IS1 repressor TnpA) Cluster2113 1 0 2 3 0 0 0 ROD_03611(putative adhesin autotransporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1519(Type V secretory pathway, adhesin AidA,outer membrane autotransporter barrel domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2711(Adhesin/invasin TibA autotransporter precursor,Type V secretory pathway, adhesin AidA,outer membrane autotransporter barrel domain,Autotransporter beta-domain) b2647(adhesin-like autotransporter),pseudob2190(unknown),pseudob4521(unknown) Cluster2114 1 1 1 1 0 1 1 ROD_49031(conserved hypothetical protein) ENC_45020(Protein of unknown function (DUF3029).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4017(hypothetical protein,hypothetical protein,glycine radical enzyme, YjjI family,Protein of unknown function (DUF3029)) b4380(conserved protein) t4609(conserved hypothetical protein) SL1344_4493(conserved hypothetical protein) Cluster2115 0 1 2 2 0 0 1 ENC_43800(Dihydrodipicolinate synthase/N-acetylneuraminate lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4106(Probable 2-keto-3-deoxy-galactonate aldolase YagE,dihydrodipicolinate synthase,dihydrodipicolinate synthase,Dihydrodipicolinate synthetase family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4180(Probable 2-keto-3-deoxy-galactonate aldolase YagE,dihydrodipicolinate synthase,dihydrodipicolinate synthase,Dihydrodipicolinate synthetase family) b0268(2-keto-3-deoxy gluconate (KDG) aldolase; CP4-6 prophage),b4298(KpLE2 phage-like element; predicted lyase/synthase) SL1344_3499(putative dihydrodipicolinate synthetase) Cluster2116 1 1 1 1 0 1 1 ROD_24321(putative transporter) ENC_42430(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4066(hypothetical protein,Uncharacterized protein conserved in bacteria,Nucleoside recognition) b4330(predicted inner membrane protein) t4564(putative membrane protein) SL1344_4445(putative membrane protein) Cluster2117 1 1 1 1 0 1 1 ROD_24311(putative transporter) ENC_42420(Uncharacterized membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4067(Inner membrane protein yjiG,hypothetical protein,Uncharacterized membrane protein,Nucleoside recognition) b4329(inner membrane protein, SpmB family) t4563(putative membrane protein) SL1344_4444(putative membrane protein) Cluster2118 1 1 1 1 0 1 1 ROD_24301(isoaspartyl dipeptidase) ENC_42410(isoaspartyl dipeptidase. Metallo peptidase. MEROPS family M38) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4068(Isoaspartyl dipeptidase,isoaspartyl dipeptidase,N-acyl-D-aspartate/D-glutamate deacylase,beta-aspartyl peptidase,Amidohydrolase family) b4328(isoaspartyl dipeptidase) t4562(probable isoaspartyl dipeptidase) SL1344_4443(probable isoaspartyl dipeptidase) Cluster2119 1 1 1 1 0 1 1 ROD_20171(flagellar hook-basal body complex protein FliE) ENC_42270(flagellar hook-basal body complex protein FliE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1886(Flagellar hook-basal body complex protein FliE,flagellar hook-basal body protein FliE,flagellar hook-basal body complex protein FliE,Flagellar hook-basal body complex protein FliE) b1937(flagellar basal-body component) t0909(flagellar hook-basal body complex protein FliE) SL1344_1897(flagellar hook-basal body complex protein FliE) Cluster2120 1 1 1 1 0 1 1 ROD_20181(flagellar M-ring protein) ENC_42260(flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1885(Flagellar M-ring protein,flagellar MS-ring protein,Type III secretory pathway, lipoprotein EscJ,flagellar M-ring protein FliF,Secretory protein of YscJ/FliF family) b1938(flagellar basal-body MS-ring and collar protein) t0908(flagellar basal-body M-ring protein) SL1344_1898(flagellar basal-body M-ring protein) Cluster2121 1 1 1 1 0 1 1 ROD_20191(puative flagellar motor switch protein) ENC_42250(flagellar motor switch protein FliG) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1884(Flagellar motor switch protein FliG,flagellar motor switch protein G,Flagellar motor switch/type III secretory pathway protein,flagellar motor switch protein FliG,FliG C-terminal domain) b1939(flagellar motor switching and energizing component) t0907(flagellar motor switch protein FliG) SL1344_1899(flagellar motor switch protein FliG) Cluster2122 1 1 1 1 0 1 1 ROD_20221(flagellar protein FliJ) ENC_42220(flagellar export protein FliJ) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1881(Flagellar fliJ protein,flagellar biosynthesis chaperone,flagellar export protein FliJ,Flagellar FliJ protein) b1942(flagellar protein) t0904(flagellar FliJ protein) SL1344_1902(flagellar biosynthesis protein) Cluster2123 1 1 1 1 0 1 1 ROD_20231(flagellar hook-length control protein) ENC_42210(Flagellar hook-length control protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1880(Flagellar hook-length control protein,flagellar hook-length control protein,Flagellar hook-length control protein FliK) b1943(flagellar hook-length control protein) t0903(flagellar hook-length control protein) SL1344_1903(flagellar hook-length control protein) Cluster2124 1 1 1 1 0 1 1 ROD_20241(flagellar protein FliL) ENC_42200(Flagellar basal body-associated protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1879(flagellar basal body-associated protein FliL,Flagellar basal body-associated protein FliL) b1944(flagellar biosynthesis protein) t0902(FliL protein) SL1344_1904(flagella biosynthesis protein) Cluster2125 1 1 1 1 0 1 1 ROD_20251(flagellar motor switch protein FliM) ENC_42190(flagellar motor switch protein FliM) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1878(Flagellar motor switch protein FliM,flagellar motor switch protein FliM,Flagellar motor switch protein,flagellar motor switch protein FliM,Flagellar motor switch protein FliM) b1945(flagellar motor switching and energizing component) t0901(flagellar motor switch protein FliM) SL1344_1905(flagellar motor switch protein FliM) Cluster2126 1 1 1 1 0 1 1 ROD_20261(flagellar motor switch protein FliN) ENC_42180(flagellar motor switch protein FliN) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1877(Flagellar motor switch protein FliN,flagellar motor switch protein FliN,Flagellar motor switch/type III secretory pathway protein,flagellar motor switch protein FliN,Surface presentation of antigens (SPOA)) b1946(flagellar motor switching and energizing component) t0900(flagellar motor switch protein FliN) SL1344_1906(flagellar motor switch protein FliN) Cluster2127 1 1 1 1 0 1 1 ROD_20271(flagellar protein FliO) ENC_42170(flagellar biosynthetic protein FliO) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1876(Flagellar protein fliO,flagellar biosynthesis protein FliO,flagellar biosynthetic protein FliO,Flagellar biosynthesis protein, FliO) b1947(flagellar biosynthesis protein) t0899(flagellar protein FliO) SL1344_1907(flagellar biosynthesis protein) Cluster2128 1 1 1 1 0 1 1 ROD_20281(flagellar biosynthetic protein FliP) ENC_42160(flagellar biosynthetic protein FliP) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1875(Flagellar biosynthetic protein fliP precursor,putative bifunctional flagellar biosynthesis protein FliO/FliP,Type III secretory pathway, component EscR,flagellar biosynthetic protein FliP,FliP family) b1948(flagellar biosynthesis protein) t0898(flagellar biosynthetic protein FliP) SL1344_1908(flagellar biosynthetic protein FliP) Cluster2129 1 1 1 1 0 1 1 ROD_20341(putative mannosyl-3-phosphoglycerate phosphatase) ENC_42110(HAD-superfamily hydrolase, subfamily IIB/mannosyl-3-phosphoglycerate phosphatase family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1868(Putative mannosyl-3-phosphoglycerate phosphatase,mannosyl-3-phosphoglycerate phosphatase,Predicted hydrolase (HAD superfamily),mannosyl-3-phosphoglycerate phosphatase family,haloacid dehalogenase-like hydrolase) b1955(predicted mannosyl-3-phosphoglycerate phosphatase) t0892(conserved hypothetical protein) SL1344_1914(Mannosyl-3-phosphoglycerate phosphatase) Cluster2130 1 1 1 1 0 1 1 ROD_20361(conserved hypothetical protein) ENC_42080(Uncharacterized small protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1866(Uncharacterized small protein,Uncharacterized small protein (DUF2158)) b1957(predicted protein) t0890(conserved hypothetical protein) SL1344_1916(conserved hypothetical protein) Cluster2131 1 1 1 1 0 1 1 ROD_21751(glucose-1-phosphate thymidylyltransferase) ENC_41270(Glucose-1-phosphate thymidylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1674(Glucose-1-phosphate thymidylyltransferase 1,glucose-1-phosphate thymidylyltransferase RfbA,CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes,glucose-1-phosphate thymidylyltransferase,Nucleotidyl transferase) b2039(glucose-1-phosphate thymidylyltransferase) t0777(TDP-glucose pyrophosphorylase) SL1344_2072(TDP-glucose pyrophosphorylase) Cluster2132 1 1 1 1 0 1 1 ROD_21761(dTDP-4-dehydrorhamnose reductase) ENC_41260(dTDP-4-dehydrorhamnose reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1673(dTDP-4-dehydrorhamnose reductase,dTDP-4-dehydrorhamnose reductase,dTDP-4-dehydrorhamnose reductase,RmlD substrate binding domain) b2040(dTDP-4-dehydrorhamnose reductase subunit, NAD(P)-binding, of dTDP-L-rhamnose synthase) t0776(dTDP-4-dehydrorhamnose reductase) SL1344_2073(dTDP-4-dehydrorhamnose reductase) Cluster2133 1 1 1 1 0 1 1 ROD_21791(colanic acid biosynthesis protein) ENC_41230(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1669(putative colanic acid biosynthesis protein,colanic acid biosynthesis protein WcaM) b2043(colanic acid biosynthesis protein) t0773(putative exported protein) SL1344_2076(putative exported protein) Cluster2134 1 1 1 1 0 1 1 ROD_21871(GDP-mannose mannosyl hydrolase)) ENC_41150(ADP-ribose pyrophosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1661(GDP-mannose mannosyl hydrolase,GDP-mannose mannosyl hydrolase NudD,NUDIX domain) b2051(GDP-mannose mannosyl hydrolase) t0764(putative O-antigen biosynthesis protein) SL1344_2084(putative O-antigen biosynthesis protein) Cluster2135 1 1 1 1 0 1 1 ROD_21881(GDP-L-fucose synthetase) ENC_41140(Nucleoside-diphosphate-sugar epimerases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1660(GDP-L-fucose synthase,dTDP-glucose 4,6-dehydratase,dTDP-glucose 4,6-dehydratase,NAD dependent epimerase/dehydratase family) b2052(bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase/ GDP-4-dehydro-6-L-deoxygalactose reductase) t0765(GDP-fucose synthetase) SL1344_2085(GDP-fucose synthetase) Cluster2136 1 1 1 1 0 1 1 ROD_21901(putative colanic acid biosynthesis acetyltransferase) ENC_41110(Acetyltransferase (isoleucine patch superfamily)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1658(Putative acetyltransferase SACOL2570,putative acyl transferase,Acetyltransferase (isoleucine patch superfamily),colanic acid biosynthesis acetyltransferase WcaF,Bacterial transferase hexapeptide (six repeats)) b2054(predicted acyl transferase) t0762(putative acetyltransferase) SL1344_2087(acetyltransferase) Cluster2137 1 1 1 1 0 1 1 ROD_21911(putative colanic acid biosynthesis glycosyl transferase) ENC_41100(Glycosyltransferases involved in cell wall biogenesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1657(PGL/p-HBAD biosynthesis glycosyltransferase Rv2957/MT3031,putative glycosyl transferase,Predicted glycosyl hydrolase,colanic acid biosynthesis glycosyltransferase WcaE,Glycosyl transferase family 2) b2055(predicted glycosyl transferase) t0761(putative glycosyl transferase) SL1344_2088(glycosyltransferase) Cluster2138 1 1 1 1 0 1 1 ROD_22241(putative ADP-ribosylglycohydrolase) ENC_40620(ADP-ribosylglycohydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1615(ADP-ribosyl-[dinitrogen reductase] hydrolase,ADP-ribosylglycohydrolase) b2099(predicted hydrolase) t0713(putative hydrolase) SL1344_2120(putative hydrolase) Cluster2139 1 1 2 0 0 1 1 ROD_31471(conserved hypothetical protein) ENC_39490(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3926(Tripartite tricarboxylate transporter family receptor),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4673(Tripartite tricarboxylate transporter family receptor) t2681(putative exported protein) SL1344_2770(putative exported protein) Cluster2140 1 1 1 1 0 1 1 ROD_26731(putative membrane protein) ENC_39390(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1441(hypothetical protein,hypothetical protein,Bacterial protein of unknown function (DUF883)) b2266(conserved protein) t0552(conserved hypothetical protein) SL1344_2280(conserved hypothetical protein) Cluster2141 1 1 1 1 0 1 1 ROD_24171(nitrate/nitrite sensor kinase) ENC_38070(Signal transduction histidine kinase, nitrate/nitrite-specific) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1261(Nitrate/nitrite sensor protein narX,nitrate/nitrite sensor protein NarQ,Signal transduction histidine kinase, nitrate/nitrite-specific,TMAO reductase sytem sensor TorS,Histidine kinase) b2469(sensory histidine kinase in two-component regulatory system with NarP (NarL)) t0379(nitrate/nitrite sensor protein) SL1344_2443(nitrate/nitrite sensor protein NarQ) Cluster2142 1 1 1 1 0 1 1 ROD_45961(GntR-family transcriptional regulator) ENC_34690(transcriptional regulator, GntR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.473(L-lactate utilization operon repressor,transcriptional regulator NanR,Transcriptional regulators,phosphonate utilization associated transcriptional regulator,FCD domain) b3226(DNA-binding transcriptional repressor of the nan operon, induced by sialic acid) t3257(putative GntR-family transcriptional regulator) SL1344_3312(putative GntR-family transcriptional regulator) Cluster2143 1 1 1 1 0 1 1 ROD_45971(N-acetylneuraminate lyase) ENC_34680(N-acetylneuraminate lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.474(N-acetylneuraminate lyase,N-acetylneuraminate lyase,N-acetylneuraminate lyase,Dihydrodipicolinate synthetase family) b3225(N-acetylneuraminate lyase) t3256(N-acetylneuraminate lyase) SL1344_3311(N-acetylneuraminate lyase) Cluster2144 1 1 1 1 0 1 1 ROD_46001(putative N-acetylmannosamine kinase) ENC_34660(N-acetylmannosamine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.477(N-acetylmannosamine kinase,N-acetylmannosamine kinase,Predicted phosphosugar isomerases,ROK family protein (putative glucokinase),ROK family) b3222(N-acetylmannosamine kinase) t3253(possible kinase) SL1344_3308(possible kinase) Cluster2145 1 1 1 1 0 1 1 ROD_46011(conserved hypothetical protein) ENC_34650(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.478(hypothetical protein,uncharacterized protein, YhcH/YjgK/YiaL family,Domain of unknown function (DUF386)) b3221(conserved protein) t3252(conserved hypothetical protein) SL1344_3307(conserved hypothetical protein) Cluster2146 1 1 1 1 0 1 1 ROD_48061(aerotaxis receptor protein) ENC_33210(PAS domain S-box) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.621(Aerotaxis receptor,methyl-accepting chemotaxis protein II,Truncated hemoglobins,nitrogen fixation negative regulator NifL,Methyl-accepting chemotaxis protein (MCP) signaling domain) b3072(fused signal transducer for aerotaxis sensory component/methyl accepting chemotaxis component) t3137(aerotaxis receptor protein) SL1344_3190(aerotaxis receptor protein) Cluster2147 0 1 1 2 0 1 1 ENC_32860(P pilus assembly protein, chaperone PapD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.650(Chaperone protein papD precursor,fimbrial chaperone protein StdC,Gram-negative pili assembly chaperone, N-terminal domain) b0717(predicted periplasmic pilus chaperone),b3047(predicted periplasmic pilin chaperone) t2938(probable fimbrial chaperone protein) SL1344_3006(probable fimbrial chaperone protein) Cluster2148 1 1 1 1 0 1 1 ROD_19251(flagellar biosynthesis protein FlhB) ENC_28790(flagellar biosynthetic protein FlhB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2002(Flagellar biosynthetic protein flhB,flagellar biosynthesis protein FlhB,flagellar biosynthetic protein FlhB,FlhB HrpN YscU SpaS Family) b1880(flagellin export apparatus, substrate specificity protein) t0963(flagellar biosynthetic protein FlhB) SL1344_1849(flagellar biosynthetic protein FlhB) Cluster2149 1 1 1 1 0 1 1 ROD_20201(flagellar assembly protein FliH) ENC_28710(Flagellar biosynthesis/type III secretory pathway protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1883(flagellar assembly protein H,type III secretion apparatus protein, HrpE/YscL family,Flagellar assembly protein FliH) b1940(negative regulator of FliI ATPase activity) t0906(flagellar assembly protein FliH) SL1344_1900(flagellar assembly protein FliH) Cluster2150 0 1 2 0 0 1 2 ENC_28190(Sugar kinases, ribokinase family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1749(Ribokinase,ribokinase,ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase,ribokinase,pfkB family carbohydrate kinase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3928(Ribokinase,ribokinase,ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase,ribokinase,pfkB family carbohydrate kinase) t3974(putative ribokinase) SL1344_1316(putative ribokinase/regulatory protein),SL1344_3513(putative kinase/trancriptional regulatory protein) Cluster2151 1 1 1 1 0 1 1 ROD_21951(putative glycosyl transferase) ENC_27410(Glycosyltransferases involved in cell wall biogenesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1653(Chondroitin polymerase,putative glycosyl transferase,Predicted glycosyl hydrolase,colanic acid biosynthesis glycosyltransferase WcaA,Glycosyl transferase family 2) b2059(predicted glycosyl transferase) t0757(hypothetical protein) SL1344_2092(colanic acid biosynthesis glycosyl transferase) Cluster2152 1 1 1 1 0 1 1 ROD_21931(putative glycosyl transferase) ENC_27390(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1655(putative glycosyl transferase,colanic acid biosynthesis glycosyltransferase WcaC,Glycosyl transferases group 1) b2057(predicted glycosyl transferase) t0759(putative glycosyl transferase) SL1344_2090(glycosyltransferase) Cluster2153 1 1 1 1 0 1 1 ROD_42891(transcriptional regulator) ENC_27160(Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.170(Putative HTH-type transcriptional regulator yhjB,DNA-binding transcriptional regulator CsgD,ATP-dependent transcriptional regulator,transcriptional regulator EpsA,Bacterial regulatory proteins, luxR family) b3520(predicted two-component system response regulator, LuxR-like HTH domain, function unknown) t3911(hypothetical luxR-family transcriptional regulator) SL1344_3571(hypothetical luxR-family transcriptional regulator) Cluster2154 1 1 1 1 0 1 1 ROD_43241(4'-phosphopantetheinyl transferase) ENC_26870(Phosphopantetheinyl transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.226(4'-phosphopantetheinyl transferase psf-1,holo-(acyl carrier protein) synthase 2,phosphopantetheine--protein transferase domain,4'-phosphopantetheinyl transferase superfamily) b3475(holo-(acyl carrier protein) synthase 2) t3939(conserved hypothetical protein) SL1344_3548(conserved hypothetical protein) Cluster2155 1 1 1 1 0 1 1 ROD_43801(putative exported protein) ENC_26380(Protein of unknown function (DUF2756).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.255(hypothetical protein,Protein of unknown function (DUF2756)) b3448(conserved protein, DUF2756 family) t3969(hypothetical protein) SL1344_3518(hypothetical protein) Cluster2156 3 1 1 0 0 1 0 ROD_31931(conserved hypothetical protein),ROD_49591(conserved hypothetical protein),pseudoROD_49201(conserved hypothetical protein (pseudogene)) ENC_26300(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3696(hypothetical protein) t4363(hypothetical protein) Cluster2157 1 1 1 1 0 1 1 ROD_04151(putative outer membrane autotransporter) ENC_23890(outer membrane autotransporter barrel domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3608(P.94,Type V secretory pathway, adhesin AidA,outer membrane autotransporter barrel domain,Autotransporter beta-domain) pseudob4580(unknown) t2491(puative autotransporter/virulence factor) SL1344_0368(puative autotransporter/virulence factor) Cluster2158 1 1 1 1 0 1 1 ROD_04161(conserved hypothetical protein) ENC_23880(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3607(putative DNA-binding transcriptional regulator) b0375(predicted DNA-binding transcriptional regulator) t2490(conserved hypothetical protein) SL1344_0369(conserved hypothetical protein) Cluster2159 1 1 1 1 0 1 1 ROD_05591(putative membrane protein) ENC_22220(Predicted membrane-bound metal-dependent hydrolases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3451(Inner membrane protein ybcI,Predicted membrane-bound metal-dependent hydrolase (DUF457)) b0527(inner membrane protein, DUF457 family) t2323(putative membrane protein) SL1344_0533(putative membrane protein) Cluster2160 1 1 1 1 0 1 1 ROD_06981(arginine/agmatine antiporter) ENC_20370(arginine/ornithine antiporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3306(Putrescine transport protein,putrescine transporter,transporter, basic amino acid/polyamine antiporter (APA) family,Amino acid permease) b0692(putrescine/proton symporter: putrescine/ornithine antiporter) t2175(putrescine-ornithine antiporter) SL1344_0682(putrescine-ornithine antiporter) Cluster2161 1 1 1 1 0 1 1 ROD_07282(putative exported protein) ENC_20030(cyd operon protein YbgT) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3264(hypothetical protein,Predicted outer membrane lipoprotein,cyd operon protein YbgT,Membrane bound YbgT-like protein) b4515(conserved protein) t2134(putative membrane protein) SL1344_0724(putative membrane protein) Cluster2162 1 1 1 1 0 1 1 ROD_08761(conserved hypothetical protein) ENC_18390(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3132(hypothetical protein,hypothetical protein,Domain of unknown function (DUF74)) b0866(conserved protein, UPF0145 family) t2003(conserved hypothetical protein) SL1344_0869(conserved hypothetical protein) Cluster2163 1 1 0 2 0 1 1 pseudoROD_16561(putative prophage integrase (pseudogene)) ENC_17490(Integrase) b1345(Rac prophage; integrase),pseudob1579(unknown) t1929(integrase) SL1344_0942(bacteriophage integrase) Cluster2164 0 1 2 1 0 1 1 ENC_17350(Antitermination protein.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1812(chaperone protein DnaJ,Antitermination protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2562(Antitermination protein) b1559(Qin prophage; predicted antitermination protein Q) t1904(putative prophage antitermination protein) SL1344_0961(antitermination Protein q) Cluster2165 1 1 1 1 0 1 1 ROD_10261(putative exported protein) ENC_16640(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2936(hypothetical protein,hypothetical protein,Uncharacterized protein conserved in bacteria (DUF2057)) b0964(conserved protein) t1843(putative secreted protein) SL1344_1017(putative secreted protein) Cluster2166 1 1 1 1 0 1 1 ROD_11001(minor curlin subunit) ENC_15990(Curlin associated repeat.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2874(Fimbrin SEF17 minor subunit,curlin minor subunit CsgB,Curlin associated repeat) b1041(curlin nucleator protein, minor subunit in curli complex) t1777(nucleation component of curlin monomers) SL1344_1080(nucleation component of curlin monomers) Cluster2167 1 1 1 1 0 1 1 ROD_11011(major curlin subunit) ENC_15980(Curlin associated repeat.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2873(Major curlin subunit precursor,major curlin subunit,Curlin associated repeat) b1042(curlin subunit, amyloid curli fibers, cryptic) t1776(major curlin subunit precursor) SL1344_1081(major curlin subunit precursor) Cluster2168 1 1 1 1 0 1 1 ROD_11021(putative curli production protein csgc precursor) ENC_15970(Thin aggregative fimbriae synthesis protein.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2872(Curli assembly protein CsgC precursor,curli assembly protein CsgC,Thin aggregative fimbriae synthesis protein) b1043(curli assembly protein) t1775(conserved hypothetical protein) SL1344_1082(curli prooduction protein) Cluster2169 1 1 1 1 0 1 1 ROD_11031(putative exported protein) ENC_15960(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2871(hypothetical protein) b1044(predicted protein) t1774(conserved hypothetical protein) SL1344_1083(conserved hypothetical protein) Cluster2170 1 1 1 1 0 1 1 ROD_11171(putative membrane protein) ENC_15850(Protein of unknown function (DUF2770).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2858(hypothetical protein,Protein of unknown function (DUF2770)) b1058(predicted protein) t1761(conserved hypothetical protein) SL1344_1096(conserved hypothetical protein) Cluster2171 1 1 1 1 0 1 1 pseudoROD_11371(flagella synthesis protein FlgN (pseudogene)) ENC_15730(Flagellar biosynthesis/type III secretory pathway chaperone) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2846(flagella synthesis chaperone protein FlgN,FlgN protein) b1070(export chaperone for FlgK and FlgL) t1749(flagella synthesis protein FlgN) SL1344_1108(flagella synthesis protein FlgN) Cluster2172 1 1 1 1 0 1 1 ROD_11381(negative regulator of flagellin synthesis (anti-sigma factor)) ENC_15720(Negative regulator of flagellin synthesis (anti-sigma28 factor)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2845(Anti-sigma-28 factor,anti-sigma28 factor FlgM,flagellar biosynthesis anti-sigma factor FlgM,Anti-sigma-28 factor, FlgM) b1071(anti-sigma factor for FliA (sigma 28)) t1748(negative regulator of flagellin synthesis) SL1344_1109(negative regulator of flagellin synthesis (anti-sigma factor)) Cluster2173 1 1 1 1 0 1 1 ROD_11391(flagellar basal body P-ring protein) ENC_15710(flagella basal body P-ring formation protein FlgA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2844(flagellar basal body P-ring biosynthesis protein FlgA,flagella basal body P-ring formation protein FlgA,SAF domain) b1072(assembly protein for flagellar basal-body periplasmic P ring) t1747(flagellar basal body P-ring protein FlgA precursor) SL1344_1110(flagellar basal body P-ring protein FlgA precursor) Cluster2174 1 1 1 1 0 1 1 ROD_11401(flagellar basal-body rod protein FlgB) ENC_15700(flagellar basal-body rod protein FlgB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2843(Putative proximal rod protein,flagellar basal body rod protein FlgB,Flagellar basal body protein,flagellar basal-body rod protein FlgB,Flagella basal body rod protein) b1073(flagellar component of cell-proximal portion of basal-body rod) t1746(putative flagellar basal-body rod protein FlgB) SL1344_1111(putative flagellar basal-body rod protein FlgB (proximal rod protein)) Cluster2175 1 1 1 1 0 1 1 pseudoROD_11411(flagellar basal-body rod protein FlgC (fragment)) ENC_15690(flagellar basal-body rod protein FlgC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2842(Putative proximal rod protein,flagellar basal body rod protein FlgC,Flagellar basal body rod protein,flagellar basal-body rod protein FlgC,Domain of unknown function (DUF1078)) b1074(flagellar component of cell-proximal portion of basal-body rod) t1745(putative flagellar basal-body rod protein FlgC) SL1344_1112(putative flagellar basal-body rod protein FlgC (proximal rod protein)) Cluster2176 1 1 1 1 0 1 1 pseudoROD_11412(peptidoglycan hydrolase FlgJ (pseudogene)) ENC_15620(flagellar rod assembly protein/muramidase FlgJ) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2835(Peptidoglycan hydrolase flgJ,flagellar rod assembly protein/muramidase FlgJ,Rod binding protein,flagellar rod assembly protein/muramidase FlgJ,Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase) b1081(muramidase) t1738(flagellar protein FlgJ) SL1344_1119(flagellar protein FlgJ) Cluster2177 1 1 1 1 0 1 1 ROD_11421(flagellar hook-associated protein 1) ENC_15610(flagellar hook-associated protein FlgK) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2834(Flagellar hook-associated protein 1,flagellar hook-associated protein FlgK,flagellar hook-associated protein FlgK,Domain of unknown function (DUF1078)) b1082(flagellar hook-filament junction protein 1) t1737(flagellar hook-associated protein 1) SL1344_1120(flagellar hook-associated protein 1) Cluster2178 1 1 1 1 0 1 1 ROD_11431(flagellar hook-associated protein 3) ENC_15600(flagellar hook-associated protein 3) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2833(Hook-filament junction protein,flagellar hook-associated protein FlgL,flagellar hook-associated protein 3,Bacterial flagellin N-terminal helical region) b1083(flagellar hook-filament junction protein) t1736(flagellar hook-associated protein 3) SL1344_1121(flagellar hook-associated protein 3) Cluster2179 1 2 1 1 0 0 1 ROD_11641(TonB-dependent receptor for Fe(III)-coprogen Fe(III)-ferrioxamine B and Fe(III)-rhodotrulic acid) ENC_11940(TonB-dependent siderophore receptor),ENC_15360(TonB-dependent siderophore receptor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2814(Outer-membrane receptor for Fe(III)-coprogen, Fe(III)-ferrioxamine B and Fe(III)-rhodotrulic acid,ferric-rhodotorulic acid outer membrane transporter,Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid,TonB-dependent siderophore receptor,TonB dependent receptor) b1102(ferric-rhodotorulic acid outer membrane transporter) SL1344_1141(outer-membrane receptor for Fe(iii)-coprogen, fe(iii)-ferrioxamine b and fe(iii)-rhodotrulic acid) Cluster2180 0 1 1 2 0 1 1 ENC_11840(GnsA/GnsB family.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2917(GnsA/GnsB family) b1550(Qin prophage; multicopy suppressor of secG(Cs) and fabA6(Ts)),b4517(Multicopy suppressor of secG(Cs) and fabA6(Ts); predicted regulator of phosphatidylethanolamine synthesis) t1068(conserved hypothetical protein) SL1344_1737(conserved hypothetical protein) Cluster2181 1 1 1 1 0 1 1 ROD_15541(protein Bdm (biofilm-dependent modulation protein)) ENC_09960(Putative biofilm-dependent modulation protein.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2348(biofilm-dependent modulation protein,Putative biofilm-dependent modulation protein) b1481(biofilm-dependent modulation protein) t1479(conserved hypothetical protein) SL1344_1494(conserved hypothetical protein) Cluster2182 1 1 1 1 0 1 1 ROD_18821(putative carbon-nitrogen hydrolase) ENC_06510(Predicted amidohydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2042(Carbon-nitrogen hydrolase) b1843(conserved protein) t1000(conserved hypothetical protein) SL1344_1811(conserved hypothetical protein) Cluster2183 1 1 1 1 0 1 1 ROD_19231(flagellar protein FlhE) ENC_06160(Flagellar protein FlhE.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2004(Flagellar protein flhE precursor,Flagellar protein FlhE) b1878(conserved protein) t0965(flagellar protein FlhE precursor) SL1344_1847(flagellar protein FlhE precursor) Cluster2184 1 1 1 1 0 1 1 ROD_19291(chemotaxis protein CheZ) ENC_06130(Chemotaxis protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2001(hypothetical protein,chemotaxis regulator CheZ,Chemotaxis phosphatase, CheZ) b1881(chemotaxis regulator, protein phosphatase for CheY) t0962(chemotaxis protein CheZ) SL1344_1850(chemotaxis protein CheZ) Cluster2185 1 1 1 1 0 1 1 ROD_19301(chemotaxis protein CheY) ENC_06120(Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2000(Chemotaxis protein CheY,chemotaxis regulatory protein CheY,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain) b1882(chemotaxis regulator transmitting signal to flagellar motor component) t0961(chemotaxis protein CheY) SL1344_1851(chemotaxis protein CheY) Cluster2186 1 1 1 1 0 1 1 ROD_19311(Chemotaxis response regulator protein-glutamate methylesterase) ENC_06110(Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1999(Chemotaxis response regulator protein-glutamate methylesterase,chemotaxis-specific methylesterase,Response regulator of citrate/malate metabolism,sporulation transcription factor Spo0A,CheB methylesterase) b1883(fused chemotaxis regulator: protein-glutamate methylesterase in two-component regulatory system with CheA) t0960(glutamate methylesterase) SL1344_1852(Chemotaxis response regulator protein-glutamate methylesterase) Cluster2187 1 1 1 1 0 1 1 ROD_19321(chemotaxis protein methyltransferase) ENC_06100(Methylase of chemotaxis methyl-accepting proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1998(Chemotaxis protein methyltransferase,chemotaxis methyltransferase CheR,Response regulator,CheR methyltransferase, SAM binding domain) b1884(chemotaxis regulator, protein-glutamate methyltransferase) t0959(chemotaxis protein methyltransferase) SL1344_1853(chemotaxis protein methyltransferase) Cluster2188 1 1 1 1 0 1 1 ROD_19401(chemotaxis protein) ENC_05990(Chemotaxis signal transduction protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1994(Chemotaxis protein CheW,purine-binding chemotaxis protein,CheW-like domain) b1887(purine-binding chemotaxis protein) t0957(purine binding chemotaxis protein) SL1344_1855(purine binding chemotaxis protein) Cluster2189 1 1 1 1 0 1 1 ROD_19421(chemotaxis protein MotB (motility protein B)) ENC_05970(Flagellar motor protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1992(Chemotaxis protein MotB,flagellar motor protein MotB,Uncharacterized protein conserved in bacteria,type VI secretion system OmpA/MotB family protein,OmpA family) b1889(protein that enables flagellar motor rotation) t0955(motility protein B) SL1344_1857(motility protein B) Cluster2190 1 1 1 1 0 1 1 ROD_19431(chemotaxis protein MotA (motility protein A)) ENC_05960(Flagellar motor component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1991(Chemotaxis protein MotA,flagellar motor protein MotA,flagellar motor stator protein MotA) b1890(proton conductor component of flagella motor) t0954(motility protein A) SL1344_1858(motility protein A) Cluster2191 1 1 1 1 0 1 1 ROD_19441(flagellar transcriptional activator) ENC_05950(Flagellar transcriptional activator (FlhC).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1990(Flagellar transcriptional regulator FlhC,transcriptional activator FlhC,Flagellar transcriptional activator (FlhC)) b1891(DNA-binding transcriptional dual regulator with FlhD) t0953(flagellar transcriptional activator) SL1344_1859(flagellar transcriptional activator) Cluster2192 1 1 1 1 0 1 1 ROD_19451(transcriptional activator FlhD) ENC_05940(Flagellar transcriptional activator (FlhD).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1989(Flagellar transcriptional regulator FlhD,transcriptional activator FlhD,Flagellar transcriptional activator (FlhD)) b1892(DNA-binding transcriptional dual regulator with FlhC) t0952(flagellar transcriptional activator FlhD) SL1344_1860(Transcriptional activator flhD) Cluster2193 1 1 1 1 0 1 1 ROD_19591(putative exported protein) ENC_05800(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1980(hypothetical protein) b1904(lipoprotein, function unknown) t0944(putative lipoprotein) SL1344_1867(putative lipoprotein) Cluster2194 1 1 1 1 0 1 1 ROD_19761(protein fliZ) ENC_05550(Phage integrase, N-terminal SAM-like domain.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1902(flagella biosynthesis protein FliZ,flagellar regulatory protein FliZ,Phage integrase, N-terminal SAM-like domain) b1921(RpoS antagonist; putative regulator of FliA activity) t0921(FliZ protein) SL1344_1884(FliZ protein) Cluster2195 1 1 1 1 0 1 1 ROD_19771(flagellar-specific Sigma F (Sigma 28) factor) ENC_05540(RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1901(Sigma-F factor,flagellar biosynthesis sigma factor,RNA polymerase sigma factor, FliA/WhiG family,Sigma-70 region 3) b1922(RNA polymerase, sigma 28 (sigma F) factor) t0920(RNA polymerase sigma transcription factor for flagellar operon) SL1344_1885(RNA polymerase sigma transcription factor for flagellar operon) Cluster2196 1 1 1 1 0 1 1 ROD_20081(flagellar filament cap protein) ENC_05510(Flagellar capping protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1899(Flagellar cap protein,flagellar capping protein,Flagellar hook-associated protein 2 C-terminus) b1924(flagellar filament capping protein) t0917(flagellar hook associated protein 2) SL1344_1889(flagellar hook associated protein (FliD)) Cluster2197 1 1 1 1 0 1 1 ROD_20091(flagellar protein FliS) ENC_05500(flagellar biosynthetic protein FliS) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1898(Flagellar protein fliS,flagellar protein FliS,flagellar protein FliS,Flagellar protein FliS) b1925(flagellar protein potentiates polymerization) t0916(flagellar protein FliS) SL1344_1890(flagellar protein FliS) Cluster2198 1 1 1 1 0 1 1 ROD_20101(flagellar protein FliT) ENC_05490(Flagellar protein FliT.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1897(Flagellar protein FliT,flagellar biosynthesis protein FliT,Flagellar protein FliT) b1926(predicted chaperone) t0915(flagellar protein FliT) SL1344_1891(flagellar protein FliT) Cluster2199 1 1 1 1 0 1 1 ROD_37221(putative exported protein) ENC_04590(SLBB-domain like (DUF1017).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4459(SLBB-domain like (DUF1017)) b4028(conserved protein) t4130(putative exported protein) SL1344_4160(putative exported protein) Cluster2200 1 1 1 1 0 1 1 ROD_30201(conserved hypothetical protein) ENC_03630(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.608(mRNA interferase HigB,Uncharacterized protein conserved in bacteria,Uncharacterized protein conserved in bacteria (DUF2136)) b3083(mRNA interferase toxin of the HigB-HigA toxin-antitoxin system) t3590(conserved hypothetical protein) SL1344_3977(conserved hypothetical protein) Cluster2201 1 1 1 1 0 1 1 ROD_22331(fimbrial chaperone protein) ENC_03270(P pilus assembly protein, chaperone PapD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1600(Chaperone protein papD precursor,putative fimbrial assembly chaperone protein StcB,Gram-negative pili assembly chaperone, N-terminal domain) b2110(predicted periplasmic pilin chaperone) t0705(putative fimbrial chaperone protein) SL1344_2128(putative fimbrial chaperone protein) Cluster2202 1 1 1 1 0 1 1 ROD_38771(DeoR-family transcriptional regulator) ENC_00320(Transcriptional regulators of sugar metabolism) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4628(Glycerol-3-phosphate regulon repressor,DNA-binding transcriptional repressor GlpR,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,CRISPR locus-related DNA-binding protein,Bacterial regulatory proteins, deoR family) b3884(predicted DNA-binding transcriptional regulator) t3596(putative DeoR-family transcriptional regulator) SL1344_3971(putative DeoR-family transcriptional regulator) Cluster2203 1 1 1 1 0 1 1 ROD_38791(putative phosphogluconate dehydrogenase) ENC_00300(3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4626(2-hydroxy-3-oxopropionate reductase,NADH-dependent gamma-hydroxybutyrate dehydrogenase,Uncharacterized protein conserved in bacteria,2-hydroxy-3-oxopropionate reductase,NAD binding domain of 6-phosphogluconate dehydrogenase) b3882(gamma-hydroxybutyrate dehydrogenase, NADH-dependent) t3598(putative oxidoreductase) SL1344_3969(putative oxidoreductase) Cluster2204 1 1 1 1 0 1 1 ROD_38801(putative sugar 1,6-diphosphate aldolase) ENC_00290(Tagatose-1,6-bisphosphate aldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4625(Uncharacterized aldolase yihT,tagatose 1,6-diphosphate aldolase,Tagatose-1,6-bisphosphate aldolase,tagatose 1,6-diphosphate aldolase,DeoC/LacD family aldolase) b3881(predicted aldolase) t3599(putative aldolase) SL1344_3968(putative aldolase) Cluster2205 1 0 4 0 1 0 0 pseudoROD_31801(IS66 family transposase B (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1726(Transposase and inactivated derivatives,IS66 Orf2 like protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3(Transposase and inactivated derivatives,IS66 Orf2 like protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4171(Transposase and inactivated derivatives,IS66 Orf2 like protein),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.133(Transposase and inactivated derivatives,IS66 Orf2 like protein) BN373_p01691(conserved hypothetical protein) Cluster2206 0 0 2 3 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.775(Transposase and inactivated derivatives,InsA C-terminal domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.779(Transposase and inactivated derivatives,InsA C-terminal domain) b0022(IS1 repressor TnpA),b1894(IS1 repressor TnpA),b3444(IS1 repressor TnpA) BN373_p01261(IS1 repressor protein InsA) Cluster2207 1 0 1 1 1 1 1 ROD_50431(two-component sensor kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1857(Probable sensor-like histidine kinase YedV,sensor kinase CusS,Predicted periplasmic ligand-binding sensor domain,heavy metal sensor kinase,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b1968(predicted sensory kinase in two-component regulatory system with YedW) BN373_p00761(copper resistant sensor kinase PcoS) t1824(histidine kinase) SL1344_1034(histidine kinase) Cluster2208 1 0 1 1 1 1 1 ROD_37481(two-component system response regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4492(Transcriptional regulatory protein ZraR,transcriptional regulatory protein ZraR,Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,nitrogen regulation protein NR(I),Sigma-54 interaction domain) b4004(fused DNA-binding response regulator in two-component regulatory system with ZraS: response regulator/sigma54 interaction protein) BN373_50011(transcriptional regulatory protein ZraR) t3457(transcriptional regulatory protein) SL1344_4113(transcriptional regulatory protein) Cluster2209 1 0 1 1 1 1 1 ROD_37491(two-component system sensor kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4493(Sensor protein ZraS,sensor protein ZraS,Signal transduction histidine kinase, nitrogen specific,phosphate regulon sensor kinase PhoR,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b4003(sensory histidine kinase in two-component regulatory system with ZraR) BN373_50001(sensor protein ZraS) t3458(two-component system sensor protein) SL1344_4112(two-component system sensor protein) Cluster2210 1 0 1 1 1 1 1 ROD_37501(zinc resistance-associated protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4494(Zinc resistance-associated protein precursor,zinc resistance protein,P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein) b4002(Zn-binding periplasmic protein) BN373_49991(zinc resistance-associated protein) t3459(possible exported protein) SL1344_4111(possible exported protein) Cluster2211 1 0 1 1 1 1 1 ROD_37511(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4495(Protein of unknown function (DUF1481)) b4001(conserved protein) BN373_49981(putative lipoprotein) t3460(conserved hypothetical protein) SL1344_4110(conserved hypothetical protein) Cluster2212 1 0 1 1 1 1 1 ROD_34861(anaerobic C4-dicarboxylate transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4344(Anaerobic C4-dicarboxylate transporter DcuB,anaerobic C4-dicarboxylate transporter,Thiol:disulfide interchange protein,transporter, anaerobic C4-dicarboxylate uptake (Dcu) family,Anaerobic c4-dicarboxylate membrane transporter) b4123(C4-dicarboxylate transporter, anaerobic; DcuS co-sensor) BN373_49821(anaerobic C4-dicarboxylate transporter DcuB) t4208(anaerobic C4-dicarboxylate transporter) SL1344_4238(anaerobic C4-dicarboxylate transporter) Cluster2213 1 0 1 1 1 1 1 ROD_37641(DNA-directed RNA polymerase, beta'-subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4509(DNA-directed RNA polymerase subunit beta',DNA-directed RNA polymerase subunit beta',DNA-directed RNA polymerase, beta' subunit/160 kD subunit,DNA-directed RNA polymerase, beta' subunit,RNA polymerase Rpb1, domain 1) b3988(RNA polymerase, beta prime subunit) BN373_49811(DNA-directed RNA polymerase, beta' subunit) t3473(DNA-directed RNA polymerase, beta'-subunit) SL1344_4093(DNA-directed RNA polymerase, beta'-subunit) Cluster2214 1 0 1 1 1 1 1 ROD_37761(bifunctional protein: biotin operon repressor, biotin-[acetyl-CoA-carboxylase] synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4524(Bifunctional protein BirA,bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor,Uncharacterized conserved protein,biotin--[acetyl-CoA-carboxylase] ligase,Biotin/lipoate A/B protein ligase family) b3973(bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase/ DNA-binding transcriptional repressor, bio-5'-AMP-binding) BN373_49711(bifunctional protein BirA) t3488(biotin operon repressor) SL1344_4082(bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase) Cluster2215 1 0 1 1 1 1 1 ROD_39051(protoporphyrinogen oxidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4653(Protoporphyrinogen IX dehydrogenase [menaquinone],protoporphyrinogen oxidase,Flavodoxin,flavodoxin,Flavodoxin domain) b3850(protoporphyrin oxidase, flavoprotein) BN373_49691(protoporphyrinogen oxidase) t3311(protoporphyrinogen oxidase) SL1344_3940(protoporphyrinogen oxidase) Cluster2216 1 0 1 1 1 1 1 ROD_39171(Sec-independent protein translocase protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4664(Sec-independent protein translocase protein TatB,sec-independent translocase,twin arginine-targeting protein translocase TatB) b3838(TatABCE protein translocation system subunit) BN373_49581(twin arginine-targeting protein translocase TatB) t3323(sec-independent protein translocase protein) SL1344_3928(sec-independent protein translocase protein) Cluster2217 1 0 1 1 1 1 1 ROD_39201(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4667(Uncharacterized protein conserved in bacteria,SCP-2 sterol transfer family) b3834(conserved protein, SCP2 family) BN373_49551(conserved hypothetical protein) t3326(conserved hypothetical protein) SL1344_3925(conserved hypothetical protein) Cluster2218 1 0 1 1 1 1 1 ROD_39221(DNA recombination protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4669(DNA recombination protein rmuC,DNA recombination protein RmuC,RmuC family) b3832(predicted recombination limiting protein) BN373_49531(DNA recombination protein RmuC) t3328(putative membrane protein) SL1344_3923(putative membrane protein) Cluster2219 1 0 1 1 1 1 1 ROD_39271(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4693(Predicted permease, DMT superfamily,carboxylate/amino acid/amine transporter,EamA-like transporter family) b3827(predicted inner membrane protein) BN373_49481(transporter, 10 TMS drug/metabolite exporter (DME) family) t3334(putative membrane protein) SL1344_3917(putative membrane protein) Cluster2220 1 0 1 1 1 1 1 ROD_39321(ATP-dependent DNA helicase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4699(ATP-dependent DNA helicase recQ,ATP-dependent DNA helicase RecQ,Lhr-like helicases,ATP-dependent DNA helicase RecQ,RQC domain) b3822(ATP-dependent DNA helicase) BN373_49421(ATP-dependent DNA helicase RecQ) t3339(ATP-dependent DNA helicase) SL1344_3912(ATP-dependent DNA helicase) Cluster2221 1 0 1 1 1 1 1 ROD_39351(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4702(hypothetical protein,putative chloramphenical resistance permease RarD,Predicted permeases,protein RarD,EamA-like transporter family) b3819(predicted chloramphenical resistance permease) BN373_49391(RarD protein) t3342(chloramphenicol-sensitive protein RarD) SL1344_3909(chloramphenicol-sensitive protein RarD) Cluster2222 1 0 1 1 1 1 1 ROD_39431(putative lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4713(Predicted small periplasmic lipoprotein) b4558(predicted lipoprotein) BN373_49321(putative lipoprotein) t3351(putative lipoprotein) SL1344_3900(putative lipoprotein) Cluster2223 1 0 1 1 1 1 1 ROD_39451(adenylate cyclase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4716(adenylate cyclase,Adenylate cyclase,Adenylate cyclase, class-I) b3806(adenylate cyclase) BN373_49301(adenylate cyclase, class I) t3358(adenylate cyclase) SL1344_3894(adenylate cyclase) Cluster2224 1 0 1 1 1 1 1 ROD_39471(uroporphyrinogen III synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4718(uroporphyrinogen-III synthase,Uroporphyrinogen-III synthase,Uroporphyrinogen-III synthase HemD) b3804(uroporphyrinogen III synthase) BN373_49281(uroporphyrinogen-III synthase) t3360(uroporphyrinogen III synthase) SL1344_3892(uroporphyrinogen III synthase) Cluster2225 1 0 1 1 1 1 1 ROD_39571(dTDP-fucosamine acetyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4735(TDP-fucosamine acetyltransferase,TDP-D-fucosamine acetyltransferase) b3790(TDP-fucosamine acetyltransferase) BN373_49181(TDP-D-fucosamine acetyltransferase) t3373(lipopolysaccharide biosynthesis protein) SL1344_3883(lipopolysaccharide biosynthesis protein) Cluster2226 1 0 1 1 1 1 1 ROD_39621(enterobacterial common antigen (ECA) polysaccharide chain length modulation protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4740(Lipopolysaccharide biosynthesis protein wzzE,lipopolysaccharide biosynthesis protein WzzE,Chain length determinant protein) b3785(Entobacterial Common Antigen (ECA) polysaccharide chain length modulation protein) BN373_49131(lipopolysaccharide biosynthesis protein WzzE) t3378(lipopolysaccharide biosynthesis protein) SL1344_3878(lipopolysaccharide biosynthesis protein) Cluster2227 1 0 1 1 1 1 1 ROD_39631(undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4741(Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase,undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase,undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase,Glycosyl transferase family 4) b3784(UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase) BN373_49121(undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase) t3379(putative undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase) SL1344_3877(putative undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase) Cluster2228 1 0 1 1 1 1 1 ROD_39751(LysR-family transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4749(HTH-type transcriptional regulator gltC,DNA-binding transcriptional regulator IlvY,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b3773(DNA-binding transcriptional dual regulator) BN373_49001(transcriptional regulator IlvY) t3390(LysR-family regulatory protein for ilvC expression) SL1344_3868(LysR-family regulatory protein for ilvC expression) Cluster2229 1 0 1 1 1 1 1 ROD_39801(acetolactate synthase isozyme II large subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4754(Acetolactate synthase isozyme 2 large subunit,acetolactate synthase 2 catalytic subunit,Glyoxylate carboligase,acetolactate synthase, large subunit, biosynthetic type,Thiamine pyrophosphate enzyme, N-terminal TPP binding domain) pseudob4488(unknown) BN373_48951(acetolactate synthase, large subunit, isozyme II) t3397(acetolactate synthase large subunit) SL1344_3861(acetolactate synthase large subunit) Cluster2230 1 1 1 1 1 0 1 pseudoROD_39811(Putative magnesium chelatase (pseudogene)) ENC_47840(Predicted ATPase with chaperone activity) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4755(Competence protein ComM,putative ATP-dependent protease,Mg-chelatase subunit ChlI,Mg chelatase-like protein,Magnesium chelatase, subunit ChlI) b3765(predicted bifunctional enzyme and transcriptional regulator) BN373_48931(ATPase, AAA family) SL1344_3860(Putative competence protein (chelatase)) Cluster2231 1 0 1 1 1 1 1 ROD_39831(LysR-family transcriptional regulator (H-NS-dependent flhD regulator)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4757(HTH-type transcriptional regulator gltC,transcriptional regulator HdfR,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,Bacterial regulatory helix-turn-helix protein, lysR family) b4480(DNA-binding transcriptional regulator) BN373_48911(transcriptional regulator HdfR) t3449(possible LysR-family transcriptional regulatory protein) SL1344_3858(possible LysR-family transcriptional regulatory protein) Cluster2232 1 0 1 1 1 1 1 ROD_37781(glutamate racemase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4530(Glutamate racemase,glutamate racemase,Xanthosine triphosphate pyrophosphatase,glutamate racemase,Asp/Glu/Hydantoin racemase) b3967(glutamate racemase) BN373_48901(glutamate racemase) t3494(glutamate racemase) SL1344_4080(glutamate racemase) Cluster2233 1 0 1 1 1 1 1 ROD_37791(vitamin B12 TonB-dependent receptor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4531(Outer membrane cobalamin translocator,vitamin B12/cobalamin outer membrane transporter,Outer membrane cobalamin receptor protein,TonB-dependent vitamin B12 receptor,TonB dependent receptor) b3966(vitamin B12/cobalamin outer membrane transporter) BN373_48891(unknown) t3495(vitamin B12 receptor protein) SL1344_4079(vitamin B12 receptor protein) Cluster2234 1 0 1 1 1 1 1 ROD_12351(putative metal-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1850(Cadmium-induced protein ZinT,zinc/cadmium-binding protein,Predicted periplasmic or secreted protein,YodA lipocalin-like domain) b1973(zinc and cadmium binding protein, periplasmic) BN373_48771(metal-binding protein) t1141(conserved hypothetical protein) SL1344_1198(conserved hypothetical protein) Cluster2235 1 0 1 1 1 1 1 pseudoROD_37911(AraC-family transcriptional regulator (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4547(Uncharacterized HTH-type transcriptional regulator ypdC,DNA-binding transcriptional regulator AraC,Adenosine deaminase,YSIRK-targeted surface antigen transcriptional regulator,Helix-turn-helix domain) b3954(predicted DNA-binding transcriptional regulator) BN373_48761(transcriptional regulator, AraC family) t3507(putative AraC-family transcriptional regulator) SL1344_4066(putative AraC-family transcriptional regulator) Cluster2236 1 0 1 1 1 1 1 ROD_37981(fructose-6-phosphate aldolase 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4554(Fructose-6-phosphate aldolase 2,fructose-6-phosphate aldolase,Transaldolase,fructose-6-phosphate aldolase,Transaldolase) b3946(fructose-6-phosphate aldolase 2) BN373_48751(fructose-6-phosphate aldolase 2) t3508(putative transaldolase) SL1344_4059(putative transaldolase) Cluster2237 1 0 1 1 1 1 1 ROD_38141(ATP-dependent protease (heat shock protein)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4570(ATP-dependent protease subunit HslV,ATP-dependent protease subunit HslV,ATP-dependent protease HslVU (ClpYQ), peptidase subunit,ATP-dependent protease HslVU, peptidase subunit,Proteasome subunit) b3932(peptidase component of the HslUV protease) BN373_48601(ATP-dependent protease HslV) t3526(heat shock protein) SL1344_4041(heat shock protein) Cluster2238 1 0 1 1 1 1 1 ROD_38451(L-rhamnose operon transcriptional activator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4595(L-rhamnose operon transcriptional activator rhaR,transcriptional activator RhaR,Adenosine deaminase,YSIRK-targeted surface antigen transcriptional regulator,AraC-like ligand binding domain) b3906(DNA-binding transcriptional activator for rhaSR, L-rhamnose-binding) BN373_48481(transcriptional activator RhaR) t3570(L-rhamnose operon transcriptional activator) SL1344_3998(L-rhamnose operon transcriptional activator) Cluster2239 1 1 1 1 1 0 1 ROD_38491(rhamnulose-1-phosphate aldolase) ENC_00630(L-rhamnulose 1-phosphate aldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4599(Rhamnulose-1-phosphate aldolase,rhamnulose-1-phosphate aldolase,Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases,rhamnulose-1-phosphate aldolase,Class II Aldolase and Adducin N-terminal domain) b3902(rhamnulose-1-phosphate aldolase) BN373_48441(rhamnulose-1-phosphate aldolase) SL1344_3994(rhamnulose-1-phosphate aldolase (ec 4.1.2.19)) Cluster2240 1 0 1 1 1 1 1 ROD_38631(putative formate dehydrogenase accessory protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4603(formate dehydrogenase accessory protein,formate dehydrogenase family accessory protein FdhD,FdhD/NarQ family) b3895(formate dehydrogenase formation protein) BN373_48231(formate dehydrogenase accessory protein FdhD) t3582(FdhD protein) SL1344_3986(FdhD protein) Cluster2241 1 1 1 0 1 1 1 ROD_38711(putative lipase) ENC_00370(Esterase/lipase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4616(Acetyl esterase,acetyl esterase,Predicted esterase,alpha/beta hydrolase fold) BN373_48161(hydrolase, alpha/beta hydrolase fold family) t3589(putative lipase) SL1344_3978(putative lipase) Cluster2242 1 0 1 1 1 1 1 ROD_38931(nitrogen regulation protein NR(I) (two-component system response regulator)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4632(Nitrogen regulation protein NR(I),nitrogen regulation protein NR(I),Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,nitrogen regulation protein NR(I),Sigma-54 interaction domain) b3868(fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein) BN373_48081(nitrogen regulation protein NR(I)) t3616(two-component system, response regulator) SL1344_3952(Two-component system, response regulator) Cluster2243 1 0 1 1 1 1 1 ROD_38961(probable GTP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4638(Probable GTP-binding protein EngB,GTP-binding protein YsxC,Predicted GTPase,ribosome biogenesis GTP-binding protein YsxC,GTPase of unknown function) b3865(GTP-binding protein required for normal cell division) BN373_48051(putative GTP-binding protein EngB) t3620(ATP/GTP-binding protein) SL1344_3948(ATP/GTP-binding protein) Cluster2244 1 0 1 1 1 1 1 ROD_38971(DNA polymerase I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4640(DNA polymerase I,DNA polymerase I,DNA polymerase I - 3'-5' exonuclease and polymerase domains,DNA polymerase I,DNA polymerase family A) b3863(fused DNA polymerase I 5'->3' polymerase/3'->5' exonuclease/5'->3' exonuclease) BN373_48041(DNA polymerase I) t3621(DNA polymerase I) SL1344_3947(DNA polymerase I) Cluster2245 1 1 1 1 1 0 1 ROD_39851(major facilitator superfamily protein) ENC_04400(drug resistance transporter, EmrB/QacA subfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4764(High-copy suppressor of rspA,putative transporter,Arabinose efflux permease,drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family,Major Facilitator Superfamily) b3754(predicted multidrug or homocysteine efflux system) BN373_47961(drug resistance MFS transporter HsrA) pseudoSL1344_3854(putative transmembrane efflux protein (pseudogene)) Cluster2246 1 0 1 1 1 1 1 ROD_40001(glucose inhibited division protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4778(Ribosomal RNA small subunit methyltransferase G,16S rRNA methyltransferase GidB,16S rRNA (guanine(527)-N(7))-methyltransferase GidB,rRNA small subunit methyltransferase G) b3740(16S rRNA m(7)G527 methyltransferase, SAM-dependent; glucose-inhibited cell-division protein) BN373_47821(methyltransferase GidB) t3646(glucose inhibited division protein) SL1344_3840(glucose inhibited division protein) Cluster2247 1 0 1 1 1 1 1 ROD_40171(phosphate transport system regulatory protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4795(Phosphate transport system protein phoU,transcriptional regulator PhoU,phosphate transport system regulatory protein PhoU,PhoU domain) b3724(negative regulator of PhoR/PhoB two-component regulator) BN373_47651(phosphate transport system regulatory protein PhoU) t3670(phosphate transport system regulatory protein) SL1344_3820(phosphate transport system regulatory protein) Cluster2248 1 0 1 1 1 1 1 ROD_40181(putative phosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4804(Phosphorylated carbohydrates phosphatase TM_1254,6-phosphogluconate phosphatase,beta-phosphoglucomutase family hydrolase,haloacid dehalogenase-like hydrolase) b3715(phosphoenolpyruvate and 6-phosphogluconate phosphatase) BN373_47611(phosphatase YieH) t3671(putative hydrolase) SL1344_3819(putative hydrolase) Cluster2249 0 1 1 1 1 1 1 ENC_03980(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4809(Multidrug resistance protein MdtL,multidrug efflux system protein MdtL,Arabinose efflux permease,drug resistance transporter, Bcr/CflA subfamily,Major Facilitator Superfamily) b3710(multidrug efflux system protein) BN373_47561(multidrug resistance protein MdtL) t3676(putative membrane transport protein) SL1344_3814(putative membrane transport protein) Cluster2250 1 0 1 1 1 1 1 ROD_40242(protein C5 component of RNase P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4814(Ribonuclease P protein component,ribonuclease P,ribonuclease P protein component,Ribonuclease P) b3704(protein C5 component of RNase P) BN373_47511(ribonuclease P protein component) t3679(ribonuclease P) SL1344_3807(RNase P, protein component) Cluster2251 1 0 1 1 1 1 1 ROD_40243(50S ribosomal subunit protein L34) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4815(50S ribosomal protein L34,50S ribosomal protein L34,Ribosomal protein L34,ribosomal protein L34,Ribosomal protein L34) b3703(50S ribosomal subunit protein L34) BN373_47501(ribosomal protein L34) t3680(50S ribosomal protein l34) SL1344_3806(50s ribosomal protein l34) Cluster2252 1 1 1 1 1 0 1 ROD_40301(galactonate operon transcriptional repressor) ENC_03870(transcriptional regulator, GntR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4823(L-lactate utilization operon repressor,transcriptional regulator NanR,Transcriptional regulators,phosphonate utilization associated transcriptional regulator,FCD domain) b4479(predicted DNA-binding transcriptional regulator) BN373_47421(galactonate utilization transcriptional repressor) SL1344_3797(galactonate operon transcriptional repressor) Cluster2253 1 1 1 1 1 0 1 ROD_40311(2-dehydro-3-deoxygalactonokinase) ENC_03860(2-keto-3-deoxygalactonate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4824(2-keto-3-deoxy-galactonokinase,2-keto-3-deoxy-gal actonokinase) b3693(2-oxo-3-deoxygalactonate kinase) BN373_47411(2-oxo-3-deoxygalactonate kinase) SL1344_3796(2-dehydro-3-deoxygalactonokinase (ec 2.7.1.58) (2-keto-3-deoxy-galactonokinase) (2-oxo-3-deoxygalactonate kinase)) Cluster2254 1 1 1 1 1 0 1 ROD_40331(galactonate dehydratase) ENC_03830(galactonate dehydratase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4826(D-galactonate dehydratase,galactonate dehydratase,L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily,muconate and chloromuconate cycloisomerases,Mandelate racemase / muconate lactonizing enzyme, N-terminal domain) b4478(galactonate dehydratase) BN373_47391(galactonate dehydratase) SL1344_3794(galactonate dehydratase (ec 4.1.2.21) (ec 4.2.1.6)) Cluster2255 1 1 1 1 1 0 1 ROD_40341(D-galactonate transporter) ENC_03820(phosphoglycerate transporter family protein/d-galactonate transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4827(D-galactonate transporter,putative 3-hydroxyphenylpropionic transporter MhpT,Arabinose efflux permease,D-galactonate transporter,Major Facilitator Superfamily) b3691(D-galactonate transporter) BN373_47381(D-galactonate transporter) SL1344_3793(d-galactonate transporter) Cluster2256 1 1 0 1 1 1 1 ROD_40391(small heat shock protein A) ENC_03790(Molecular chaperone (small heat shock protein)) b3687(heat shock chaperone) BN373_47351(small heat shock protein IbpA) t3709(heat shock protein A) SL1344_3776(heat shock protein A) Cluster2257 1 1 1 1 1 0 1 ROD_40501(putative membrane protein) ENC_03730(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4838(Inner membrane protein yidH,Predicted membrane protein,Domain of unknown function DUF) b3676(inner membrane protein, DUF202 family) BN373_47281(conserved hypothetical protein) SL1344_3773(conserved hypothetical protein) Cluster2258 0 1 1 1 1 1 1 ENC_03430(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4856(hypothetical protein) b4555(predicted periplasmic protein) BN373_46881(conserved hypothetical protein) t3744(putative secreted protein) SL1344_3739(putative secreted protein) Cluster2259 1 0 1 1 1 1 1 ROD_41611(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.30(Uncharacterized protein involved in outer membrane biogenesis,AsmA family) b3655(conserved protein) BN373_46561(AsmA family protein) t3771(putative exported protein) SL1344_3714(putative exported protein) Cluster2260 1 0 1 1 1 1 1 ROD_38201(Cell division protein zapB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4574(Cell division protein ZapB,septal ring assembly protein ZapB,Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF904)) b3928(septal ring assembly factor, stimulates cell division) BN373_46511(conserved hypothetical protein) t3530(conserved hypothetical protein) SL1344_4037(conserved hypothetical protein) Cluster2261 1 0 1 1 1 1 1 ROD_38321(CDP-diacylglycerol pyrophosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4584(CDP-diacylglycerol pyrophosphatase,CDP-diacylglycerol pyrophosphatase,CDP-diacylglycerol pyrophosphatase,CDP-diacylglycerol pyrophosphatase) b3918(CDP-diacylglycerol phosphotidylhydrolase) BN373_46491(CDP-diacylglycerol pyrophosphatase) t3555(CDP-diglyceride hydrolase) SL1344_4013(CDP-diglyceride hydrolase) Cluster2262 1 0 1 1 1 1 1 ROD_41661(guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.35(Bifunctional (p)ppGpp synthase/hydrolase SpoT,bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase,Guanosine polyphosphate pyrophosphohydrolases/synthetases,RelA/SpoT family protein,Region found in RelA / SpoT proteins) b3650(bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase) BN373_46401(guanosine-3',5'-bis(diphosphate) 3'-diphosphatase) t3776(guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase) SL1344_3708(guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; CG Site No. 156) Cluster2263 1 1 1 1 1 0 1 ROD_41691(putative DNA ligase) ENC_02710(NAD-dependent DNA ligase (contains BRCT domain type II)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.38(DNA ligase B,NAD-dependent DNA ligase LigB,DNA ligase, NAD-dependent,NAD-dependent DNA ligase adenylation domain) b3647(DNA ligase, NAD(+)-dependent) BN373_46371(NAD(+)-dependent DNA ligase LigB) SL1344_3705(putative DNA ligase) Cluster2264 1 0 1 1 1 1 1 ROD_41781(50S ribosomal subunit protein L28) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.47(50S ribosomal protein L28,50S ribosomal protein L28,Ribosomal protein L28,ribosomal protein L28,Ribosomal L28 family) b3637(50S ribosomal subunit protein L28) BN373_46201(ribosomal protein L28) t3790(50S ribosomal subunit protein L28) SL1344_3694(50S ribosomal subunit protein L28) Cluster2265 1 0 1 1 1 1 1 ROD_41831(3-deoxy-D-manno-octulosonic-acid transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.51(3-deoxy-D-manno-octulosonic-acid transferase,3-deoxy-D-manno-octulosonic-acid transferase,Uncharacterized protein conserved in bacteria,3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)) b3633(3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase)) BN373_46151(3-deoxy-D-manno-octulosonic-acid transferase) t3794(3-deoxy-D-manno-octulosonic-acid transferase) SL1344_3690(3-deoxy-D-manno-octulosonic-acid transferase) Cluster2266 1 0 1 1 1 1 1 ROD_42021(putative polysaccharide deacetylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.70(hypothetical protein,Divergent polysaccharide deacetylase) b3614(predicted polysaccharide deacetylase) BN373_46001(polysaccharide deacetylase family protein) t3813(putative exported protein) SL1344_3672(putative exported protein) Cluster2267 1 0 1 1 1 1 1 ROD_42031(putative peptidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.71(Septal ring factor,AmiB activator,Membrane-bound metallopeptidase,Peptidase family M23) b3613(activator of AmiB,C murein hydrolases, septal ring factor) BN373_45991(M23 peptidase domain protein) t3814(conserved hypothetical protein) SL1344_3671(conserved hypothetical protein) Cluster2268 1 0 1 1 1 1 1 ROD_42191(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.85(hypothetical protein) b4554(predicted protein) BN373_45871(conserved hypothetical protein) t3831(hypothetical protein) SL1344_3653(hypothetical protein) Cluster2269 1 0 1 1 1 1 1 ROD_42271(selenocysteine-specific elongation factor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.93(SelB translation factor,selenocysteinyl-tRNA-specific translation factor,GTPases - translation elongation factors,selenocysteine-specific translation elongation factor,Elongation factor Tu GTP binding domain) b3590(selenocysteinyl-tRNA-specific translation factor) BN373_45811(selenocysteine-specific translation elongation factor) t3837(selenocysteine-specific elongation factor) SL1344_3647(selenocysteine-specific elongation factor) Cluster2270 1 1 1 1 1 0 1 ROD_42441(putative membrane-associated acyltransferase) ENC_47320(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.123(Inner membrane protein YiaH,Uncharacterized protein conserved in bacteria,Acyltransferase family) b3561(O-acetyltransferase for enterobacterial common antigen (ECA)) BN373_45681(putative acyltransferase) SL1344_3623(putative membrane protein) Cluster2271 0 2 0 0 2 1 1 ENC_10440(Uncharacterized protein conserved in bacteria),ENC_35240(Uncharacterized protein conserved in bacteria) BN373_45611(hypothetical protein),BN373_p00831(conserved hypothetical protein) t3867(conserved hypothetical protein) SL1344_3618(conserved hypothetical protein) Cluster2272 2 1 0 0 1 1 1 ROD_22671(putative 3-hydroxyphenylpropionic acid transporter),ROD_42511(Major Facilitator Superfamily transporter) ENC_47750(Arabinose efflux permease) BN373_45531(4-hydroxybenzoate transporter) t0676(putative n-hydroxybenzoate transporter) SL1344_2156(putative n-hydroxybenzoate transporter) Cluster2273 1 0 1 1 1 1 1 ROD_42671(dipeptide ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.144(Glutathione import ATP-binding protein GsiA,dipeptide transporter ATP-binding subunit,ABC-type oligopeptide transport system, ATPase component,nickel import ATP-binding protein NikE,Oligopeptide/dipeptide transporter, C-terminal region) b3540(dipeptide transporter) BN373_45331(dipeptide ABC transporter, ATP-binding protein DppF) t3889(dipeptide transport ATP-binding protein DppF) SL1344_3592(dipeptide transport ATP-binding protein DppF) Cluster2274 1 0 1 1 1 1 1 ROD_42731(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.156(cell division protein,Flp pilus assembly protein, ATPase CpaE,cellulose synthase operon protein YhjQ,YhjQ protein) pseudob3534(unknown) BN373_45211(cellulose synthase operon protein YhjQ) t3897(conserved hypothetical protein) SL1344_3585(conserved hypothetical protein) Cluster2275 1 0 1 1 1 1 1 ROD_43021(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.202(Ribosomal RNA small subunit methyltransferase J,putative methyltransferase,Protein of unknown function (DUF548)) b3497(predicted SAM-dependent methyltransferase) BN373_44981(conserved hypothetical protein) t3923(conserved hypothetical protein) SL1344_3558(conserved hypothetical protein) Cluster2276 1 0 1 1 1 1 1 pseudoROD_43031(putative oligopeptide transporter (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.203(Dipeptide and tripeptide permease B,dipeptide/tripeptide permease B,amino acid/peptide transporter (Peptide:H+ symporter),POT family) b3496(dipeptide and tripeptide permease B) BN373_44971(amino acid/peptide transporter) t3924(putative PTR2 family transport protein) SL1344_3557(putative PTR2 family transport protein) Cluster2277 1 0 1 1 1 1 1 ROD_43071(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.207(hypothetical protein,anaerobic glycerol-3-phosphate dehydrogenase subunit B,Predicted oxidoreductase,flavoprotein, HI0933 family,HI0933-like protein) b3492(predicted oxidoreductase with FAD/NAD(P)-binding domain) BN373_44931(pyridine nucleotide-disulfide oxidoreductase family protein) t3928(putative exported protein) SL1344_3553(putative exported protein) Cluster2278 1 0 1 1 1 1 1 ROD_43161(nickel responsive regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.220(Nickel-responsive regulator,nickel responsive regulator,nickel-responsive transcriptional regulator NikR,NikR C terminal nickel binding domain) b3481(DNA-binding transcriptional repressor, Ni-binding) BN373_44901(nickel-responsive transcriptional regulator NikR) t3938(nickel responsive regulator) SL1344_3549(nickel responsive regulator) Cluster2279 0 1 1 1 1 1 1 ENC_26940(Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1455(UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase,UDP-4-amino-4-deoxy-L-arabinose--oxoglutar ate aminotransferase,Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis,UDP-4-keto-6-deoxy-N-acetylglucosamine 4-aminotransferase,DegT/DnrJ/EryC1/StrS aminotransferase family) b2253(uridine 5'-(beta-1-threo-pentapyranosyl-4-ulose diphosphate) aminotransferase, PLP-dependent) BN373_44821(UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase) t0566(putative lipopolysaccharide biosynthesis protein) SL1344_2266(putative lipopolysaccharide biosynthesis protein) Cluster2280 0 1 1 1 1 1 1 ENC_26920(Methionyl-tRNA formyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1453(Polymyxin resistance protein PmrI,bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase,Folate-dependent phosphoribosylglycinamide formyltransferase PurN,methionyl-tRNA formyltransferase,NAD dependent epimerase/dehydratase family) b2255(fused UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'-decarboxylase) BN373_44801(UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase) t0564(putative lipopolysaccharide modification protein) SL1344_2268(putative lipopolysaccharide modification protein) Cluster2281 0 1 1 1 1 1 1 ENC_26910(Predicted xylanase/chitin deacetylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1452(Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD,4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD,Polysaccharide deacetylase) b2256(Undecaprenyl phosphate-alpha-L-ara4FN deformylase) BN373_44791(polysaccharide deacetylase domain protein) t0563(conserved hypothetical protein) SL1344_2269(conserved hypothetical protein) Cluster2282 0 1 1 1 1 1 1 ENC_26900(4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1451(Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase,4-amino-4-deoxy-L-arabinose transferase,Dolichyl-phosphate-mannose-protein mannosyltransferase) b2257(4-amino-4-deoxy-L-arabinose transferase) BN373_44781(undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyltransferase) t0562(melittin resistance protein) SL1344_2270(melittin resistance protein PqaB) Cluster2283 0 1 1 1 1 1 1 ENC_26890(Membrane transporters of cations and cationic drugs) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1450(Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE,4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE,Membrane transporters of cations and cationic drugs,EamA-like transporter family) b4544(undecaprenyl phosphate-alpha-L-ara4N exporter; flippase ArnEF subunit) BN373_44771(multidrug resistance protein, SMR family) t0561(putative membrane protein) SL1344_2271(putative inner membrane protein) Cluster2284 1 0 1 1 1 1 1 ROD_43431(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.227(hypothetical protein,pheromone autoinducer 2 transporter,sporulation integral membrane protein YtvI,Domain of unknown function DUF20) b3474(inner membrane protein, predicted membrane permease, UPF0118 family) BN373_44751(putative membrane protein) t3940(putative membrane protein) SL1344_3547(putative membrane protein) Cluster2285 1 0 1 1 1 1 1 ROD_43441(major facilitator superfamily protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.228(hypothetical protein,major facilitator superfamily transporter,Arabinose efflux permease,drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family,Major Facilitator Superfamily) b3473(inner membrane protein, predicted transporter) BN373_44741(transporter, major facilitator family) t3941(putative membrane protein) SL1344_3546(putative membrane protein) Cluster2286 1 0 1 1 1 1 1 ROD_43751(glycerol-3-phosphate ABC transporter, substrate-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.250(glycerol-3-phosphate transporter periplasmic binding protein,Maltose-binding periplasmic proteins/domains,Bacterial extracellular solute-binding protein) b3453(glycerol-3-phosphate transporter subunit) BN373_44501(glycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein) t3964(glycerol-3-phosphate-binding periplasmic protein) SL1344_3523(glycerol-3-phosphate-binding periplasmic protein) Cluster2287 1 0 1 1 1 1 1 ROD_43901(low-affinity gluconate transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.263(Gnt-I system,low affinity gluconate transporter,H+/gluconate symporter and related permeases,transporter, gluconate:H+ symporter (GntP) family,GntP family permease) b4476(gluconate transporter, low affinity GNT 1 system) BN373_44381(gluconate transporter GntU) t3979(low-affinity gluconate transporter) SL1344_3507(low-affinity gluconate transporter) Cluster2288 0 1 1 1 1 1 1 ENC_22060(Protein of unknown function (DUF1471).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3637(Multiple stress resistance protein BhsA precursor,hypothetical protein,Protein of unknown function (DUF1471)) b0329(periplasmic protein, function unknown, YhcN family) BN373_44201(conserved hypothetical protein) t2498(probable secreted protein) SL1344_0361(probable secreted protein) Cluster2289 1 0 1 1 1 1 1 ROD_44181(transcription elongation factor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.294(Transcript cleavage factor greB,transcription elongation factor GreB,Transcription elongation factor,transcription elongation factor GreB,domain) b3406(transcript cleavage factor) BN373_44141(transcription elongation factor GreB) t4003(transcription elongation factor GreB) SL1344_3470(transcription elongation factor GreB) Cluster2290 1 0 1 1 1 1 1 ROD_44201(two-component sensor kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.296(Osmolarity sensor protein EnvZ,osmolarity sensor protein,Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation,heavy metal sensor kinase,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b3404(sensory histidine kinase in two-component regulatory system with OmpR) BN373_44121(osmolarity sensor protein EnvZ) t4005(two-component sensor kinase EnvZ) SL1344_3468(two-component sensor kinase EnvZ) Cluster2291 1 0 1 1 1 1 1 ROD_44251(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.303(Putative membrane protein igaA homolog,Intracellular growth attenuator protein IgaA) b3398(inner membrane protein) BN373_44071(putative membrane protein) t4011(putative membrane protein) SL1344_3462(putative membrane protein) Cluster2292 1 0 1 1 1 1 1 ROD_44271(penicillin-binding protein 1A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.305(Penicillin-binding protein 1A,penicillin-binding protein 1a,Membrane carboxypeptidase/penicillin-binding protein,penicillin-binding protein, 1A family,Transglycosylase) b3396(fused penicillin-binding protein 1a: murein transglycosylase/murein transpeptidase) BN373_44051(penicillin-binding protein 1A) t4013(penicillin-binding protein 1A) SL1344_3460(penicillin-binding protein 1A) Cluster2293 1 0 1 1 1 1 1 ROD_44301(putative fimbrial protein HofO) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.308(hypothetical protein) b3393(protein required for the utilization of DNA as a carbon source) BN373_44021(hypothetical protein) t4015(putative membrane protein) SL1344_3457(putative membrane protein) Cluster2294 1 0 1 1 1 1 1 ROD_44321(putative fimbrial protein HofQ) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.310(Type IV pilus biogenesis and competence protein pilQ precursor,outer membrane porin HofQ,Type II secretory pathway, component HofQ,type IV pilus secretin PilQ,Bacterial type II and III secretion system protein) b3391(protein required for the utilization of DNA as a carbon source; fimbrial transporter homolog) BN373_44001(protein transporter HofQ) t4018(type II secretion system protein) SL1344_3455(type II secretion system protein) Cluster2295 1 0 1 1 1 1 1 ROD_44341(3-dehydroquinate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.312(3-dehydroquinate synthase,3-dehydroquinate synthase,3-dehydroquinate synthetase,3-dehydroquinate synthase,3-dehydroquinate synthase) b3389(3-dehydroquinate synthase) BN373_43971(3-dehydroquinate synthase) t4020(3-dehydroquinate synthase) SL1344_3453(3-dehydroquinate synthase) Cluster2296 1 0 1 1 1 1 1 ROD_44411(siroheme synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.327(Siroheme synthase,siroheme synthase,Uroporphyrinogen-III methylase,uroporphyrinogen-III C-methyltransferase,Tetrapyrrole (Corrin/Porphyrin) Methylases) b3368(fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase) BN373_43911(siroheme synthase) t4028(siroheme synthase) SL1344_3444(siroheme synthase) Cluster2297 1 0 1 1 1 1 1 ROD_44471(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.333(hypothetical protein,Protein of unknown function (DUF2559)) b3362(predicted protein) BN373_43851(conserved hypothetical protein) t4034(conserved hypothetical protein) SL1344_3438(conserved hypothetical protein) Cluster2298 1 0 1 1 1 1 1 ROD_44481(cell filamentation protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.334(Probable adenosine monophosphate-protein transferase fic,cell filamentation protein Fic,Protein involved in cell division,Fic/DOC family) b3361(stationary-phase protein, cell division) BN373_43841(cell filamentation protein Fic) t4035(cell filamentation protein Fic) SL1344_3437(cell filamentation protein Fic) Cluster2299 1 0 1 1 1 1 1 ROD_44491(para-aminobenzoate synthase glutamine amidotransferase component I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.335(Para-aminobenzoate synthase glutamine amidotransferase component II,para-aminobenzoate synthase component II,Phosphoribosylanthranilate isomerase,glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase,Glutamine amidotransferase class-I) b3360(aminodeoxychorismate synthase, subunit II) BN373_43831(aminodeoxychorismate synthase, component II) t4036(para-aminobenzoate synthase, glutamine amidotransferase component II) SL1344_3436(para-aminobenzoate synthase, glutamine amidotransferase component II) Cluster2300 1 1 1 1 1 0 1 ROD_44511(putative membrane protein) ENC_25700(integral membrane protein, YccS/YhfK family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.337(Inner membrane protein yccS,Predicted membrane protein,integral membrane protein, YccS/YhfK family,FUSC-like inner membrane protein yccS) b3358(conserved inner membrane protein) BN373_43811(integral membrane protein, YccS/YhfK family) SL1344_3434(conserved membrane protein) Cluster2301 1 0 1 1 1 1 1 ROD_44541(probable phosphoribulokinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.340(Phosphoribulokinase, plasmid,phosphoribulokinase,Phosphoribulokinase / Uridine kinase family) b3355(predicted phosphoribulokinase) BN373_43781(phosphoribulokinase/uridine kinase family protein) t4041(phosphoribulokinase) SL1344_3431(phosphoribulokinase) Cluster2302 1 1 1 1 1 0 1 ROD_44561(putative hydrolase) ENC_25630(Predicted hydrolase of the alpha/beta-hydrolase fold) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.342(putative hydrolase,Predicted hydrolase of the alpha/beta-hydrolase fold,alpha/beta hydrolase fold) b3353(predicted hydrolase) BN373_43761(hydrolase, alpha/beta fold family) SL1344_3429(conserved hypothetical protein) Cluster2303 1 0 1 1 1 1 1 ROD_44681(glutathione-regulated potassium-efflux system protein (K(+)/H(+)antiporter)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.345(NEM-activable K(+)/H(+) antiporter,glutathione-regulated potassium-efflux system protein KefB,Kef-type K+ transport system, predicted NAD-binding component,transporter, monovalent cation:proton antiporter-2 (CPA2) family,Sodium/hydrogen exchanger family) b3350(potassium:proton antiporter) BN373_43731(glutathione-regulated potassium-efflux system protein KefB) t4048(glutathione-regulated potassium-efflux system protein) SL1344_3424(glutathione-regulated potassium-efflux system protein (K(+)/H(+)antiporter)) Cluster2304 0 1 1 1 1 1 1 ENC_25360(type 4 prepilin peptidase 2. Aspartic peptidase. MEROPS family A24A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.361(Type 4 prepilin-like proteins leader peptide-processing enzyme,Type IV leader peptidase family) b3335(bifunctional prepilin leader peptidase/ methylase) BN373_43581(unknown) t4063(Type III leader peptidase) SL1344_3409(Type III leader peptidase) Cluster2305 1 0 1 1 1 1 1 ROD_45251(30S ribosomal subunit protein S4) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.400(30S ribosomal protein S4,30S ribosomal protein S4,ribosomal protein S4,Ribosomal protein S4/S9 N-terminal domain) b3296(30S ribosomal subunit protein S4) BN373_43331(ribosomal protein S4) t4089(30S ribosomal subunit protein S4) SL1344_3383(30S ribosomal subunit protein S4) Cluster2306 1 0 1 1 1 1 1 ROD_45341(methionyl-tRNA formyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.409(Methionyl-tRNA formyltransferase,methionyl-tRNA formyltransferase,Folate-dependent phosphoribosylglycinamide formyltransferase PurN,methionyl-tRNA formyltransferase,Formyl transferase) b3288(10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase) BN373_43241(methionyl-tRNA formyltransferase) t4097(methionyl-tRNA formyltransferase) SL1344_3374(methionyl-tRNA formyltransferase) Cluster2307 1 0 1 1 1 1 1 ROD_45381(putative DNA topoisomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.413(DNA topoisomerase 1,DNA topoisomerase I,Zn-finger domain associated with topoisomerase type I,DNA topoisomerase I,Topoisomerase DNA binding C4 zinc finger) b3283(predicted DNA topoisomerase) BN373_43201(topoisomerase DNA-binding C4 zinc finger domain protein) t4101(conserved hypothetical protein) SL1344_3370(conserved hypothetical protein) Cluster2308 1 0 1 1 1 1 1 ROD_45391(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.414(t(6)A37 threonylcarbamoyladenosine biosynthesis protein RimN,tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein,Putative translation factor (SUA5),Sua5/YciO/YrdC/YwlC family protein,yrdC domain) b3282(tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein) BN373_43191(Sua5/YciO/YrdC/YwlC family protein) t4102(conserved hypothetical protein) SL1344_3369(conserved hypothetical protein) Cluster2309 1 1 1 1 1 0 1 ROD_45491(acriflavine resistance protein E) ENC_35150(RND family efflux transporter, MFP subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.429(Acriflavine resistance protein A precursor,multidrug efflux system transporter AcrA,efflux transporter, RND family, MFP subunit,HlyD family secretion protein) b3265(cytoplasmic membrane lipoprotein) BN373_43131(acriflavine resistance protein E) SL1344_3363(acriflavine resistance protein E (protein envc)) Cluster2310 1 1 1 1 1 0 1 ROD_45511(probable acref/envcd operon repressor (TetR-family transcriptional regulator)) ENC_35140(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.430(Probable acrEF/envCD operon repressor,DNA-binding transcriptional regulator EnvR,transcriptional repressor BetI,MAATS-type transcriptional repressor, C-terminal region) b3264(DNA-binding transcriptional regulator) BN373_43121(DNA-binding transcriptional regulator EnvR) SL1344_3362(TetR-family transcriptional regulator) Cluster2311 1 0 1 1 1 1 1 ROD_45611(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1853(Flavocytochrome yedZ,putative sulfite oxidase subunit YedZ,Ferric reductase like transmembrane component) b1972(inner membrane heme subunit for periplasmic YedYZ reductase) BN373_43031(putative membrane protein) t3293(putative membrane protein) SL1344_3351(putative membrane protein) Cluster2312 1 0 1 1 1 1 1 ROD_45671(rod shape-determining protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.452(Rod shape-determining protein mreD,rod shape-determining protein MreD,rod shape-determining protein MreD,rod shape-determining protein MreD) b3249(cell wall structural complex MreBCD transmembrane component MreD) BN373_42981(rod shape-determining protein MreD) t3287(rod shape-determining protein) SL1344_3344(rod shape-determining protein) Cluster2313 1 0 1 1 1 1 1 ROD_45701(possible exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.455(hypothetical protein,Uncharacterized protein involved in outer membrane biogenesis,conserved hypothetical protein) b4472(conserved membrane protein, predicted transporter) BN373_42951(conserved hypothetical protein TIGR02099) t3284(possible exported protein) SL1344_3341(possible exported protein) Cluster2314 1 0 1 1 1 1 1 ROD_46051(glutamate synthase [NADPH] large subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.480(Glutamate synthase [NADPH] large chain precursor,glutamate synthase subunit alpha,Uncharacterized conserved protein,formylmethanofuran dehydrogenase subunit C,Conserved region in glutamate synthase) b3212(glutamate synthase, large subunit) BN373_42741(glutamate synthase (NADPH), large subunit) t3247(glutamate synthase [NADPH] large chain precursor) SL1344_3302(glutamate synthase [NADPH] large chain precursor) Cluster2315 1 0 1 1 1 1 1 ROD_46321(sugar fermentation stimulation protein B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.505(DNA-binding transcriptional regulator Nlp,Predicted transcriptional regulator) b3188(DNA-binding transcriptional activator of maltose metabolism) BN373_42481(sugar fermentation stimulation protein B) t3223(Ner-like regulatory protein) SL1344_3278(Ner-like regulatory protein) Cluster2316 1 1 0 1 1 1 1 ROD_46671(30S ribosomal subunit protein S15) ENC_34030(SSU ribosomal protein S15P) b3165(30S ribosomal subunit protein S15) BN373_42251(ribosomal protein S15) t3201(30S ribosomal subunit protein S15) SL1344_3256(30S ribosomal subunit protein S15) Cluster2317 1 0 1 1 1 1 1 ROD_46681(polyribonucleotide nucleotidyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.532(Polyribonucleotide nucleotidyltransferase,polynucleotide phosphorylase/polyadenylase,Lipoprotein NlpI, contains TPR repeats,polyribonucleotide nucleotidyltransferase,3' exoribonuclease family, domain 1) b3164(polynucleotide phosphorylase/polyadenylase) BN373_42241(polyribonucleotide nucleotidyltransferase) t3200(polynucleotide phosphorylase) SL1344_3255(polynucleotide phosphorylase) Cluster2318 1 0 1 1 1 1 1 ROD_46691(TPR repeat lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.533(Lipoprotein NlpI precursor,lipoprotein NlpI,Lipoprotein NlpI, contains TPR repeats,putative PEP-CTERM system TPR-repeat lipoprotein,Tetratricopeptide repeat) b3163(lipoprotein involved in osmotic sensitivity and filamentation) BN373_42231(lipoprotein NlpI) t3199(conserved hypothetical protein) SL1344_3254(conserved hypothetical protein) Cluster2319 1 0 1 1 1 1 1 ROD_46801(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.544(Semialdehyde dehydrogenase, NAD binding domain) b3152(predicted nucleoside-diphosphate-sugar epimerase) BN373_42121(NAD-binding domain 4 protein) t3188(conserved hypothetical protein) SL1344_3241(conserved hypothetical protein) Cluster2320 1 0 1 1 1 1 1 ROD_46841(DnaA initiator-associating factor for replication initiation (putative phophosugar-binding protein)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.547(DnaA initiator-associating protein diaA,DnaA initiator-associating protein DiaA,phosphoheptose isomerase,SIS domain) b3149(DnaA initiator-associating factor for replication initiation) BN373_42091(DnaA initiator-associating protein DiaA) t3186(probable phosphoheptose isomerase) SL1344_3239(probable phosphoheptose isomerase) Cluster2321 1 0 1 1 1 1 1 ROD_47671(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.584(hypothetical protein) b3107(predicted protein) BN373_41971(conserved hypothetical protein) t3157(conserved hypothetical protein) SL1344_3209(conserved hypothetical protein) Cluster2322 1 0 1 1 1 1 1 ROD_47681(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.585(Pirin-like protein YhaK,Pirin) b3106(redox-sensitive bicupin) BN373_41961(pirin family protein) t3156(conserved hypothetical protein) SL1344_3208(conserved hypothetical protein) Cluster2323 1 0 1 1 1 1 1 ROD_47871(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.590(hypothetical protein) b3100(conserved protein) BN373_41911(conserved hypothetical protein) t3151(conserved hypothetical protein) SL1344_3203(conserved hypothetical protein) Cluster2324 1 1 1 1 1 1 0 ROD_47891(putative membrane protein) ENC_33550(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.592(hypothetical protein,hypothetical protein,Bacterial protein of unknown function (DUF883)) b3098(conserved protein) BN373_41891(conserved hypothetical protein) t3149(conserved hypothetical protein) Cluster2325 1 1 1 1 1 0 1 ROD_48041(2,4-dienoyl-CoA reductase [NADPH]) ENC_33420(2,4-dienoyl-CoA reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.612(2,4-dienoyl-CoA reductase [NADPH],NADPH dehydrogenase NamA,Protoporphyrinogen oxidase,mycofactocin system FadH/OYE family oxidoreductase 2,NADH:flavin oxidoreductase / NADH oxidase family) b3081(2,4-dienoyl-CoA reductase, NADH and FMN-linked) BN373_41721(2,4-dienoyl-CoA reductase) SL1344_3192(2,4-dienoyl-CoA reductase [NADPH] (ec 1.3.1.34) (2,4-dienoyl coenzyme A reductase)) Cluster2326 1 0 1 1 1 1 1 ROD_36201(G/U mismatch-specific DNA glycosylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.625(G/U mismatch-specific DNA glycosylase,G/U mismatch-specific DNA glycosylase,G:T/U mismatch-specific DNA glycosylase,mismatch-specific thymine-DNA glycosylate (mug),Uracil DNA glycosylase superfamily) b3068(G/U mismatch-specific DNA glycosylase; xanthine DNA glycosylase) BN373_41301(G/U mismatch-specific DNA glycosylase) t3132(G/U mismatch-specific DNA glycosylase) SL1344_3186(G/U mismatch-specific DNA glycosylase) Cluster2327 1 0 1 1 1 1 1 ROD_36181(DNA primase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.627(DNA primase,DNA primase,DNA primase (bacterial type),DNA primase,DNA primase catalytic core, N-terminal domain) b3066(DNA primase) BN373_41281(DNA primase) t3130(DNA primase) SL1344_3184(DNA primase) Cluster2328 1 0 1 1 1 1 1 ROD_36001(multifunctional Cca protein [includes: tRNA nucleotidyltransferase; 2'-nucleotidase; 2',3'-cyclic phosphodiesterase; phosphatase]) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.637(Multifunctional CCA protein,multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase,UTP:GlnB (protein PII) uridylyltransferase,CCA tRNA nucleotidyltransferase,Poly A polymerase head domain) b3056(fused tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase and phosphatase) BN373_41131(multifunctional CCA protein) t3124(tRNA nucleotidyltransferase) SL1344_3177(tRNA nucleotidyltransferase) Cluster2329 1 0 1 1 1 1 1 ROD_35981(putative adenylate cyclase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.639(Uncharacterized conserved protein,CYTH domain) b3054(predicted adenylate cyclase) BN373_41111(adenylate cyclase) t3122(conserved hypothetical protein) SL1344_3175(conserved hypothetical protein) Cluster2330 1 0 1 1 1 1 1 ROD_35841(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.659(Bifunctional glutathionylspermidine synthetase/amidase,bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase,Glutathionylspermidine synthase) b3038(Glutathionylspermidine synthase homolog) BN373_41031(putative glutathionylspermidine synthase) t3109(conserved hypothetical protein) SL1344_3162(conserved hypothetical protein) Cluster2331 1 0 1 1 1 1 1 ROD_35791(putative phosphoesterase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.664(3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA,cyclic 3',5'-adenosine monophosphate phosphodiesterase,Calcineurin-like phosphoesterase) b3032(3',5' cAMP phosphodiesterase) BN373_40981(cyclic AMP phosphodiesterase) t3104(conserved hypothetical protein) SL1344_3157(cyclic 3',5'-adenosine monophosphate phosphodiesterase) Cluster2332 1 0 1 1 1 1 1 ROD_35771(topoisomerase IV subunit B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.666(DNA topoisomerase 4 subunit B,DNA topoisomerase IV subunit B,DNA topoisomerase IV, B subunit,DNA gyrase B) b3030(DNA topoisomerase IV, subunit B) BN373_40961(DNA topoisomerase IV, B subunit) t3102(topoisomerase IV subunit B) SL1344_3155(topoisomerase IV subunit B) Cluster2333 1 1 1 1 1 0 1 ROD_35691(modulator of drug activity B) ENC_32590(Putative NADPH-quinone reductase (modulator of drug activity B)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.674(Modulator of drug activity B,glutathione-regulated potassium-efflux system ancillary protein KefF,Putative NADPH-quinone reductase (modulator of drug activity B),Flavodoxin-like fold) b3028(NADPH quinone reductase) BN373_40941(modulator of drug activity B) SL1344_3153(putative oxidoreductase) Cluster2334 1 1 1 1 1 0 1 ROD_35601(2,5-diketo-D-gluconic acid reductase A) ENC_32500(Aldo/keto reductases, related to diketogulonate reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.696(2,5-diketo-D-gluconic acid reductase A,2,5-diketo-D-gluconate reductase A,Predicted oxidoreductase,voltage-dependent potassium channel beta subunit,Aldo/keto reductase family) b3012(2,5-diketo-D-gluconate reductase A) BN373_40841(2,5-didehydrogluconate reductase A) SL1344_3139(2,5-diketo-D-gluconic acid reductase A) Cluster2335 1 0 1 1 1 1 1 ROD_35591(putative alcohol dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.697(Alcohol dehydrogenase YqhD,aldehyde reductase,Glycerol dehydrogenase and related enzymes,lactaldehyde reductase,Iron-containing alcohol dehydrogenase) b3011(aldehyde reductase, NADPH-dependent) BN373_40831(alcohol dehydrogenase yqhD) t3084(probable alcohol dehydrogenase) SL1344_3138(probable alcohol dehydrogenase) Cluster2336 1 0 1 1 1 1 1 ROD_50261(A/G-specific adenine glycosylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.788(A/G-specific adenine glycosylase,adenine DNA glycosylase,3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase,A/G-specific adenine glycosylase,HhH-GPD superfamily base excision DNA repair protein) b2961(adenine DNA glycosylase) BN373_40491(A/G-specific adenine glycosylase) t3023(A/G-specific adenine glycosylase) SL1344_3085(A/G-specific adenine glycosylase) Cluster2337 1 0 1 1 1 1 1 ROD_10981(probable CsgAB operon transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2875(CsgBAC operon transcriptional regulatory protein,DNA-binding transcriptional regulator CsgD,ATP-dependent transcriptional regulator,transcriptional regulator EpsA,Bacterial regulatory proteins, luxR family) b1040(DNA-binding transcriptional activator for csgBA) BN373_40361(transcriptional regulator, LuxR family) t1778(putative regulatory protein) SL1344_1079(csg operon transcriptional regulator protein) Cluster2338 1 0 1 1 1 1 1 ROD_50501(putative peptidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.815(Uncharacterized metalloprotease yggG,heat shock protein HtpX,Putative Zn-dependent protease, contains TPR repeats,Peptidase family M48) b2936(heat shock protein binding to Era protein; predicted peptidase) BN373_40221(peptidase, M48B family) t2997(conserved hypothetical protein) SL1344_3053(conserved hypothetical protein) Cluster2339 1 0 1 1 1 1 1 ROD_50681(fructose-bisphosphate aldolase class 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.831(Fructose-bisphosphate aldolase class 2,fructose-bisphosphate aldolase,Fructose/tagatose bisphosphate aldolase,fructose-bisphosphate aldolase, class II,Fructose-bisphosphate aldolase class-II) b2925(fructose-bisphosphate aldolase, class II) BN373_40181(fructose-bisphosphate aldolase) t2987(fructose 1,6-bisphosphate aldolase) SL1344_3044(fructose 1,6-bisphosphate aldolase) Cluster2340 1 0 1 1 1 1 1 ROD_49271(putative monooxygenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.850(2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase,oxidoreductase,ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family,FAD binding domain) b2906(predicted oxidoreductase with FAD/NAD(P)-binding domain) BN373_40061(ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family) t2974(possible monooxygenase) SL1344_3032(possible monooxygenase) Cluster2341 1 0 1 1 1 1 1 ROD_49331(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.855(hypothetical protein,hypothetical protein,ASCH domain) b2900(conserved protein, UPF0267 family) BN373_39951(conserved hypothetical protein) t2968(conserved hypothetical protein) SL1344_3026(conserved hypothetical protein) Cluster2342 1 0 1 1 1 1 1 ROD_49351(tRNA-modifying protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.857(tRNA-modifying protein ygfZ,putative global regulator,Glycine cleavage system T protein (aminomethyltransferase),folate-binding protein YgfZ,Aminomethyltransferase folate-binding domain) b2898(Plumbagin resistance protein; hda suppressor; also involved in methylthio modification at 2-methylthio-6-iodeadenosine in tRNA) BN373_39931(tRNA-modifying protein YgfZ) t2966(conserved hypothetical protein) SL1344_3024(conserved hypothetical protein) Cluster2343 1 0 1 1 1 1 1 ROD_49391(tyrosine recombinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.861(Tyrosine recombinase XerD,site-specific tyrosine recombinase XerD,Site-specific recombinase XerD,tyrosine recombinase XerD,Phage integrase family) b2894(site-specific tyrosine recombinase) BN373_39891(tyrosine recombinase XerD) t2962(site-specific integrase/recombinase) SL1344_3020(Tyrosine recombinase xerD) Cluster2344 1 0 1 1 1 1 1 ROD_49411(single-stranded DNA-specific exonuclease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.863(Single-stranded-DNA-specific exonuclease recJ,ssDNA exonuclease RecJ,Uncharacterized protein conserved in bacteria,single-stranded-DNA-specific exonuclease RecJ,DHHA1 domain) b2892(ssDNA exonuclease, 5'--> 3'-specific) BN373_39871(single-stranded-DNA-specific exonuclease RecJ) t2960(single-stranded DNA-specific exonuclease) SL1344_3018(single-stranded DNA-specific exonuclease) Cluster2345 0 0 1 1 2 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.184(10K-L protein,acid-resistance protein) b3509(acid-resistance protein) BN373_39541(acid-resistance protein),BN373_41371(conserved hypothetical protein) t1475(putative secreted protein) SL1344_1492(putative secreted protein) Cluster2346 1 1 1 1 1 0 1 ROD_29131(fimbrial subunit FimI) ENC_33260(P pilus assembly protein, pilin FimA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4082(Type-1A pilin,fimbrial protein FimI,P pilus assembly protein, pilin FimA,Fimbrial protein) b4315(fimbrial protein involved in type 1 pilus biosynthesis) BN373_39201(fimbrial protein) SL1344_3606(long polar fimbria protein A (LpfA)) Cluster2347 1 0 1 1 1 1 1 ROD_29101(fimbrial regulatory protein FimB) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3655(Tyrosine recombinase XerD,tyrosine recombinase,Site-specific recombinase XerD,tyrosine recombinase XerD,Phage integrase family) b4312(tyrosine recombinase/inversion of on/off regulator of fimA) BN373_39171(type 1 fimbriae regulatory protein FimB) t2160(probable DNA recombinase) SL1344_0697(putative type 1 fimbriae regulatory protein) Cluster2348 2 0 1 1 1 1 0 ROD_03651(putative fimbrial usher protein),ROD_27781(fimbrial usher protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3844(Heat shock protein E,putative fimbrial outer membrane usher protein,Fimbrial Usher protein) b0139(predicted outer membrane usher protein) BN373_39091(outer membrane usher protein MrkC) t0188(outer membrane usher protein HtrE precursor) Cluster2349 1 1 1 0 1 1 1 ROD_38521(putative porin) ENC_07140(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4601(Sucrose porin precursor) BN373_38911(putative glycoporin RfaY) t2713(putative glycoporin) SL1344_2801(putative glycoporin) Cluster2350 1 0 1 1 1 1 1 ROD_28751(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.907(hypothetical protein,integral membrane protein, YkoY family,Integral membrane protein TerC family) b2832(inner membrane protein, UPF0053 family) BN373_38711(integral membrane protein, TerC family) t2915(putative membrane protein) SL1344_2984(putative membrane protein) Cluster2351 1 0 1 1 1 1 1 ROD_28741(DNA mismatch repair protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.908(Methyl-directed mismatch repair protein,DNA mismatch repair protein,DNA mismatch repair protein,DNA mismatch repair endonuclease MutH,DNA mismatch repair enzyme MutH) b2831(methyl-directed mismatch repair protein) BN373_38701(DNA mismatch repair endonuclease MutH) t2914(DNA mismatch repair protein) SL1344_2983(DNA mismatch repair protein mutH) Cluster2352 1 0 1 1 1 1 1 ROD_28651(prepilin peptidase-dependent protein C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.917(hypothetical protein,Tfp pilus assembly protein PilV,Prepilin peptidase dependent protein C) b2823(predicted protein) BN373_38621(prepilin peptidase dependent protein C) t2905(prepilin peptidase dependent protein C precursor) SL1344_2975(prepilin peptidase dependent protein C precursor) Cluster2353 1 0 1 1 1 1 1 ROD_28641(exodeoxyribonuclease V gamma subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.918(Exodeoxyribonuclease V gamma chain,exonuclease V subunit gamma,Exonuclease V gamma subunit,exodeoxyribonuclease V, gamma subunit,Exodeoxyribonuclease V, gamma subunit) b2822(exonuclease V (RecBCD complex), gamma chain) BN373_38611(exodeoxyribonuclease V, gamma subunit) t2904(exonuclease V subunit) SL1344_2974(exonuclease V subunit) Cluster2354 1 0 1 1 1 1 1 ROD_28611(exodeoxyribonuclease V alpha subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.921(Exodeoxyribonuclease V alpha chain,exonuclease V subunit alpha,Uncharacterized conserved protein,exodeoxyribonuclease V, alpha subunit,Putative ATPase (DUF699)) b2819(exonuclease V (RecBCD complex), alpha chain) BN373_38581(exodeoxyribonuclease V, alpha subunit) t2901(exonuclease V alpha-subunit) SL1344_2971(exonuclease V alpha-subunit) Cluster2355 1 0 1 1 1 1 1 ROD_21031(bifunctional adenosylcobalamin biosynthesis protein [includes adenosylcobinamide kinase; adenosylcobinamide-phosphate guanylyltransferase]) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1759(Adenosylcobinamide kinase,adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase,Cobinamide kinase / cobinamide phosphate guanyltransferase) b1993(bifunctional cobinamide kinase/ cobinamide phosphate guanylyltransferase) BN373_38131(cobinamide kinase/cobinamide phosphate guanyltransferase) t0856(cobinamide kinase and guanylyltransferase) SL1344_1994(cobinamide kinase and guanylyltransferase) Cluster2356 1 0 1 1 1 1 1 ROD_21011(nicotinate-nucleotide dimethylbenzimidazole phosphoribosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1761(Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase,nicotinate-nucleotide--dimethylbe nzimidazole phosphoribosyltransferase,nicotinate-nucleotide--dimethylbe nzimidazole phosphoribosyltransferase,Phosphoribosyltransferase) b1991(nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase) BN373_38121(nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase) t0858(nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyl transferase) SL1344_1992(Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase) Cluster2357 1 0 1 1 1 1 1 ROD_28491(putative fuscose transport/metabolism protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.971(L-fucose mutarotase,L-fucose mutarotase,ABC-type ribose transport system, auxiliary component,RbsD / FucU transport protein family) b2804(L-fucose mutarotase) BN373_38021(fucose operon protein FucU) t2886(fuscose operon fucU protein) SL1344_2958(fuscose operon fucU protein) Cluster2358 1 0 1 1 1 1 1 ROD_28481(L-fuculokinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.972(L-fuculokinase,L-fuculokinase,L-rhamnose isomerase,L-fuculokinase,FGGY family of carbohydrate kinases, N-terminal domain) b2803(L-fuculokinase) BN373_38011(L-fuculokinase) t2885(L-fuculose kinase) SL1344_2957(L-fuculose kinase) Cluster2359 1 0 1 1 1 1 1 ROD_28331(putative SecY-interacting protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.982(hypothetical protein,SecY interacting protein Syd,Syd protein) b2793(secY-interacting protein) BN373_37811(syd protein) t2875(syd protein) SL1344_2947(syd protein) Cluster2360 1 0 1 1 1 1 1 ROD_30211(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.984(hypothetical protein,Domain of unknown function, DUF446) b2792(conserved protein) BN373_37791(conserved hypothetical protein) t2874(conserved hypothetical protein) SL1344_2946(conserved hypothetical protein) Cluster2361 1 0 1 1 1 1 1 ROD_30321(GTP pyrophosphokinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.992(GTP pyrophosphokinase,(p)ppGpp synthetase I/GTP pyrophosphokinase,Guanosine polyphosphate pyrophosphohydrolases/synthetases,RelA/SpoT family protein,Region found in RelA / SpoT proteins) b2784((p)ppGpp synthetase I/GTP pyrophosphokinase) BN373_37701(GTP diphosphokinase) t2865(GTP pyrophosphokinase) SL1344_2937(GTP pyrophosphokinase) Cluster2362 1 0 1 1 1 1 1 ROD_30651(multifunctional stationary-phase survival protein [includes: 5'/3'-nucleotidase; exopolyphosphatase]) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1029(5'/3'-nucleotidase SurE,5'(3')-nucleotidase/polyphosphatase,5'/3'-nucleotidase SurE,Survival protein SurE) b2744(broad specificity 5'(3')-nucleotidase and polyphosphatase) BN373_37501(multifunctional protein SurE) t2828(stationary phase survival protein) SL1344_2906(Acid phosphatase surE) Cluster2363 1 1 1 0 1 1 1 ROD_30761(iron ABC transporter, permease protein) ENC_21530(ABC-type Mn2+/Zn2+ transport systems, permease components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2728(Manganese transport system membrane protein mntB,high-affinity zinc transporter membrane component,anchored repeat-type ABC transporter, permease subunit,ABC 3 transport family) BN373_37131(iron ABC transporter, permease protein AfeC) t2765(iron transport protein, inner membrane component) SL1344_2843(Iron transport protein, inner membrane component) Cluster2364 1 1 1 0 1 1 1 ROD_30771(iron ABC transporter, ATP-binding protein) ENC_21540(ABC-type Mn/Zn transport systems, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2727(Uncharacterized ABC transporter ATP-binding protein HI_1470,manganese/iron transporter ATP-binding protein,ABC-type enterochelin transport system, ATPase component,anchored repeat-type ABC transporter, ATP-binding subunit,ABC transporter) BN373_37121(iron ABC transporter, ATP-binding protein) t2764(iron transport protein, ATP-binding component) SL1344_2842(Iron transport protein, ATP-binding component) Cluster2365 1 0 1 1 1 1 1 ROD_30871(formate hydrogenlyase subunit 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1052(Hydrogenase-4 component A,putative oxidoreductase Fe-S binding subunit,Uncharacterized Fe-S center protein,dimethylsulfoxide reductase, chain B,4Fe-4S dicluster domain) b2724(hydrogenase 3, Fe-S subunit) BN373_36941(formate hydrogenlyase, subunit B) t2754(formate hydrogenlyase subunit 2) SL1344_2832(formate hydrogenlyase subunit 2) Cluster2366 1 0 1 1 1 1 1 ROD_31091(sorbitol-6-phosphate 2-dehydrogenase (glucitol-6-phosphate dehydrogenase)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1071(Sorbitol-6-phosphate 2-dehydrogenase,sorbitol-6-phosphate dehydrogenase,Uncharacterized conserved protein,rhamnulose-1-phosphate aldolase/alcohol dehydrogenase,short chain dehydrogenase) b2705(sorbitol-6-phosphate dehydrogenase) BN373_36731(sorbitol-6-phosphate 2-dehydrogenase) t2736(sorbitol-6-phosphate 2-dehydrogenase) SL1344_2815(sorbitol-6-phosphate 2-dehydrogenase (glucitol-6-phosphate dehydrogenase)) Cluster2367 1 0 1 1 1 1 1 ROD_31101(glucitol/sorbitol-specific PTS system EIIA component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1072(PTS system glucitol/sorbitol-specific transporter subunit IIA,PTS system, glucitol/sorbitol-specific IIA component,PTS system glucitol/sorbitol-specific IIA component) b2704(glucitol/sorbitol-specific enzyme IIA component of PTS) BN373_36721(glucitol/sorbitol-specific phosphotransferase enzyme IIA component) t2735(glucitol/sorbitol-specific IIA component of PTS system) SL1344_2814(PTS system, glucitol/sorbitol-specific IIA component) Cluster2368 1 0 1 1 1 1 1 ROD_31161(regulatory protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1079(Regulatory protein recX,recombination regulator RecX,Uncharacterized protein conserved in bacteria,RecX family) b2698(regulatory protein for RecA) BN373_36631(regulatory protein RecX) t2729(putative regulatory protein RecX) SL1344_2808(Regulatory protein recX) Cluster2369 1 0 1 1 1 1 1 ROD_31221(putative outer membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1088(Inner membrane protein yqaA,SNARE associated Golgi protein) b2689(inner membrane protein, COG1238 family) BN373_36581(putative membrane protein) t2716(putative membrane protein) SL1344_2804(putative membrane protein) Cluster2370 1 0 1 1 1 1 1 ROD_31231(Glutamate--cysteine ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1089(Glutamate--cysteine ligase,glutamate--cysteine ligase,glutamate--cysteine ligase,Glutamate-cysteine ligase) b2688(glutamate-cysteine ligase) BN373_36571(glutamate--cysteine ligase) t2715(gamma-glutamylcysteine synthetase) SL1344_2803(Glutamate--cysteine ligase) Cluster2371 1 1 1 1 1 0 1 ROD_31311(glycine betaine/L-proline ABC transporter, ATP-binding protein) ENC_29260(glycine betaine/L-proline transport ATP binding subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1102(Glycine betaine/L-proline transport ATP-binding protein ProV,glycine betaine transporter ATP-binding subunit,ABC-type proline/glycine betaine transport system, ATPase component,glycine betaine/L-proline transport ATP binding subunit,ABC transporter) b2677(glycine betaine transporter subunit) BN373_36461(glycine betaine/L-proline ABC transporter, ATP-binding protein) SL1344_2794(glycine betaine/l-proline transport ATP-binding protein) Cluster2372 1 0 1 1 1 1 1 ROD_31331(ribonucleoside-diphosphate reductase 2 alpha chain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1104(Ribonucleoside-diphosphate reductase 2 subunit alpha,ribonucleotide-diphosphate reductase subunit alpha,ribonucleoside-diphosphate reductase, class 1b, alpha subunit,Ribonucleotide reductase, barrel domain) b2675(ribonucleoside-diphosphate reductase 2, alpha subunit) BN373_36441(ribonucleoside-diphosphate reductase, alpha subunit) t2704(ribonucleoside-diphosphate reductase 2 alpha chain) SL1344_2792(ribonucleoside-diphosphate reductase 2 alpha chain) Cluster2373 1 0 1 1 1 1 1 ROD_31401(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1111(Inner membrane protein ygaP,molybdopterin biosynthesis protein MoeB,Rhodanese-like domain) b2668(predicted inner membrane protein with hydrolase activity) BN373_36321(rhodanese domain protein) t2693(conserved hypothetical protein) SL1344_2782(conserved hypothetical protein) Cluster2374 1 0 1 1 1 1 1 ROD_31411(ArsR-family transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1112(Probable HTH-type transcriptional regulator ygaV,Uncharacterized protein conserved in archaea,Bacterial regulatory protein, arsR family) b2667(tributyltin-inducible repressor of ygaVP) BN373_36311(transcriptional regulator, ArsR family) t2692(putative transcriptional regulator) SL1344_2781(putative transcriptional regulator) Cluster2375 1 0 1 1 1 1 1 ROD_42301(aldehyde dehydrogenase B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.96(Aldehyde dehydrogenase B,betaine aldehyde dehydrogenase,Delta 1-pyrroline-5-carboxylate dehydrogenase,betaine aldehyde dehydrogenase,Aldehyde dehydrogenase family) b3588(aldehyde dehydrogenase B) BN373_36271(aldehyde dehydrogenase) t3839(aldehyde dehydrogenase B) SL1344_3645(aldehyde dehydrogenase B) Cluster2376 1 3 0 0 1 1 0 ROD_18181(putative major fimbrial subunit) ENC_04140(P pilus assembly protein, pilin FimA),ENC_13860(P pilus assembly protein, pilin FimA),ENC_47700(P pilus assembly protein, pilin FimA) BN373_36261(putative fimbrial-like protein) t3659(probable fimbrial subunit protein) Cluster2377 1 0 1 1 1 1 1 ROD_25671(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1124(hypothetical protein,hypothetical protein,Uncharacterised protein family (UPF0125)) b2618(conserved protein, UPF0125 family) BN373_35941(RnfH family protein) t2640(conserved hypothetical protein) SL1344_2658(conserved hypothetical protein) Cluster2378 1 0 1 1 1 1 1 ROD_25361(ribosomal large subunit pseudouridine synthase D) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1146(Ribosomal large subunit pseudouridine synthase D,23S rRNA pseudouridine synthase D,pseudouridine synthase, RluA family,RNA pseudouridylate synthase) b2594(23S rRNA pseudouridine synthase; specific to U1911, U1915, and U1917) BN373_35711(ribosomal large subunit pseudouridine synthase D) t2618(ftsH suppressor protein SfhB) SL1344_2622(ftsH suppressor protein SfhB) Cluster2379 1 0 1 1 1 1 1 ROD_25301(CDP-diacylglycerol-serine O-phosphatidyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1154(CDP-diacylglycerol--serine O-phosphatidyltransferase,phosphatidylserine synthase,cardiolipin synthase,Phospholipase D Active site motif) b2585(phosphatidylserine synthase (CDP-diacylglycerol-serine O-phosphatidyltransferase)) BN373_35661(CDP-diacylglycerol--serine O-phosphatidyltransferase) t0258(CDP-diacylglycerol-serine O-phosphatidyltransferase) SL1344_2616(CDP-diacylglycerol-serine O-phosphatidyltransferase) Cluster2380 1 0 1 1 1 1 1 ROD_25261(putative RNA methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1158(23S rRNA (guanosine-2'-O-)-methyltransferase RlmB,putative methyltransferase,RNA methyltransferase, TrmH family, group 3,SpoU rRNA Methylase family) b2581(predicted methyltransferase) BN373_35621(RNA methyltransferase, TrmH family) t0262(putative RNA methyltransferase) SL1344_2612(putative RNA methyltransferase) Cluster2381 1 0 1 1 1 1 1 ROD_25211(L-aspartate oxidase (quinolinate synthetase B).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1165(L-aspartate oxidase,L-aspartate oxidase,Aspartate oxidase,L-aspartate oxidase,FAD binding domain) b2574(quinolinate synthase, L-aspartate oxidase (B protein) subunit) BN373_35571(L-aspartate oxidase) t0269(L-aspartate oxidase) SL1344_2605(L-aspartate oxidase (quinolinate synthetase B)) Cluster2382 1 1 0 1 1 1 1 ROD_25131(Ribonuclease III) ENC_36940(RNAse III) b2567(RNase III) BN373_35501(ribonuclease III) t0277(ribonuclease III) SL1344_2543(Ribonuclease III) Cluster2383 1 0 1 1 1 1 1 ROD_25041(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1179(hypothetical protein,HAD hydrolase, family IF,haloacid dehalogenase-like hydrolase) b2560(conserved protein) BN373_35431(HAD hydrolase YhfB) t0288(putative membrane protein) SL1344_2531(putative membrane protein) Cluster2384 1 0 1 1 1 1 1 ROD_25031(tRNA-specific adenosine deaminase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1180(tRNA-specific adenosine deaminase,tRNA-specific adenosine deaminase,Pyrimidine deaminase,riboflavin biosynthesis protein RibD,Cytidine and deoxycytidylate deaminase zinc-binding region) b2559(tRNA-specific adenosine deaminase) BN373_35421(tRNA-specific adenosine deaminase) t0289(conserved hypothetical protein) SL1344_2530(conserved hypothetical protein) Cluster2385 1 0 1 1 1 1 1 ROD_25011(putative lytic transglycosylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1181(Membrane-bound lytic murein transglycosylase F precursor,membrane-bound lytic transglycosylase F,lysine-arginine-ornithine-binding periplasmic protein,Bacterial extracellular solute-binding proteins, family 3) b2558(membrane-bound lytic transglycosylase F, murein hydrolase) BN373_35411(bacterial extracellular solute-binding, family 3/transglycosylase SLT domain protein) t0290(putative exported protein) SL1344_2529(putative exported protein) Cluster2386 1 0 1 1 1 1 1 ROD_25001(Phosphoribosylformylglycinamidine synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1182(Phosphoribosylformylglycinamidine synthase,phosphoribosylformylglycinamidine synthase,Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain,phosphoribosylformylglycinamidine synthase,AIR synthase related protein, C-terminal domain) b2557(phosphoribosylformyl-glycineamide synthetase) BN373_35401(phosphoribosylformylglycinamidine synthase) t0291(phosphoribosylformylglycineamide synthetase) SL1344_2527(Phosphoribosylformylglycinamidine synthase) Cluster2387 1 0 1 1 1 1 1 ROD_24941(flavohemoprotein (haemoglobin-like protein)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1189(Nitric oxide dioxygenase,bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2,Uncharacterized Fe-S protein,phenylacetate-CoA oxygenase/reductase, PaaK subunit,Globin) b2552(fused nitric oxide dioxygenase/dihydropteridine reductase 2) BN373_35351(flavohemoprotein) t0300(flavohemoprotein) SL1344_2518(flavohemoprotein (haemoglobin-like protein)) Cluster2388 2 0 0 1 1 0 2 ROD_24901(putative sugar transporter),ROD_37141(D-xylose-proton symporter (D-xylose transporter)) b4031(D-xylose transporter) BN373_35291(unknown) SL1344_4351(putative sugar transport protein),SL1344_4352(putative sugar transport protein) Cluster2389 1 0 1 1 1 1 1 ROD_24671(peptidase B (aminopeptidase B)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1213(Peptidase B,aminopeptidase B,Cytosol aminopeptidase family, catalytic domain) b2523(aminopeptidase B) BN373_35121(peptidase B) t0320(peptidase B) SL1344_2498(Peptidase B) Cluster2390 1 1 0 1 1 1 1 ROD_24661(enhanced serine sensitivity protein) ENC_37330(SseB protein.) b2522(rhodanase-like enzyme, sulfur transfer from thiosulfate) BN373_35111(SseB protein) t0321(SseB protein) SL1344_2497(SseB protein) Cluster2391 1 0 1 1 1 1 1 ROD_24611(nucleoside diphosphate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1218(Nucleoside diphosphate kinase,mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-,Nucleoside diphosphate kinase,Nucleoside diphosphate kinase) b2518(multifunctional nucleoside diphosphate kinase and apyrimidinic endonuclease and 3'-phosphodiesterase) BN373_35051(nucleoside diphosphate kinase) t0330(nucleoside diphosphate kinase) SL1344_2488(nucleoside diphosphate kinase (ndk)) Cluster2392 1 1 0 1 1 1 1 ROD_24581(4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase) ENC_37470(1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase) b2515(1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase) BN373_35021(4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase) t0333(GcpE protein) SL1344_2485(4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase) Cluster2393 1 0 1 1 1 1 1 ROD_24571(histidyl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1222(Histidine--tRNA ligase,histidyl-tRNA synthetase,Histidyl-tRNA synthetase,histidine--tRNA ligase,tRNA synthetase class II core domain (G, H, P, S and T)) b2514(histidyl tRNA synthetase) BN373_35011(histidyl-tRNA synthetase) t0334(histidyl-tRNA synthetase) SL1344_2484(Histidyl-tRNA synthetase) Cluster2394 1 0 1 1 1 1 1 ROD_24561(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1223(hypothetical protein,Uncharacterized protein conserved in bacteria,Uncharacterized protein conserved in bacteria (DUF2133)) b2513(conserved protein, UPF0070 family) BN373_35001(conserved hypothetical protein) t0335(putative membrane protein) SL1344_2483(putative membrane protein) Cluster2395 1 0 1 1 1 1 1 ROD_24541(GTP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1225(GTP-binding protein EngA,GTP-binding protein Der,Fe2+ transport system protein B,ribosome-associated GTPase EngA,GTPase of unknown function) b2511(GTPase; multicopy suppressor of ftsJ) BN373_34981(GTP-binding protein EngA) t0337(putative GTP-binding protein) SL1344_2481(GTP-binding protein engA) Cluster2396 1 0 1 1 1 1 1 ROD_24501(exodeoxyribonuclease 7 large subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1230(Exodeoxyribonuclease 7 large subunit,exodeoxyribonuclease VII large subunit,exodeoxyribonuclease VII, large subunit,Exonuclease VII, large subunit) b2509(exonuclease VII, large subunit) BN373_34951(exodeoxyribonuclease VII, large subunit) t0345(exodeoxyribonuclease large subunit) SL1344_2473(Probable exodeoxyribonuclease VII large subunit) Cluster2397 1 0 1 1 1 1 1 ROD_24491(inosine-5'-monophosphate dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1231(Inosine-5'-monophosphate dehydrogenase,inosine 5'-monophosphate dehydrogenase,L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases,inosine-5'-monophosphate dehydrogenase,IMP dehydrogenase / GMP reductase domain) b2508(IMP dehydrogenase) BN373_34941(inosine-5'-monophosphate dehydrogenase) t0346(inosine-5'-monophosphate dehydrogenase) SL1344_2472(inosine-5'-monophosphate dehydrogenase) Cluster2398 1 1 1 1 1 0 1 ROD_24471(putative membrane protein) ENC_37740(Protein of unknown function (DUF2633).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1235(Protein of unknown function (DUF2633)) b2504(predicted protein) BN373_34881(conserved hypothetical protein) SL1344_2468(conserved hypothetical inner membrane protein) Cluster2399 1 0 1 1 1 1 1 ROD_24421(phosphoribosylaminoimidazole synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1241(Phosphoribosylformylglycinamidine cyclo-ligase,phosphoribosylaminoimidazole synthetase,Phosphoribosylamine-glycine ligase,phosphoribosylformylglycinamidine cyclo-ligase,AIR synthase related protein, C-terminal domain) b2499(phosphoribosylaminoimidazole synthetase) BN373_34831(phosphoribosylformylglycinamidine cyclo-ligase) t0358(phosphoribosylformylglycinamidine cyclo-ligase) SL1344_2462(Phosphoribosylformylglycinamidine cyclo-ligase) Cluster2400 1 0 1 1 1 1 1 ROD_24411(uracil phosphoribosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1242(Uracil phosphoribosyltransferase,uracil phosphoribosyltransferase,uracil phosphoribosyltransferase,Phosphoribosyl transferase domain) b2498(uracil phosphoribosyltransferase) BN373_34801(uracil phosphoribosyltransferase) t0359(uracil phosphoribosyltransferase) SL1344_2461(uracil phosphoribosyltransferase) Cluster2401 1 0 1 1 1 1 1 ROD_24391(DnaA-homolog protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1244(DnaA-homolog protein hda,DNA replication initiation factor,DnaA regulatory inactivator Hda,Bacterial dnaA protein) b2496(ATPase regulatory factor involved in DnaA inactivation) BN373_34781(DnaA regulatory inactivator Hda) t0361(conserved hypothetical protein) SL1344_2459(conserved hypothetical protein) Cluster2402 1 0 1 1 1 1 1 ROD_24281(glycine cleavage system transcriptional repressor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1249(Gcv operon repressor,glycine cleavage system transcriptional repressor,ACT domain-containing protein,ACT domain) b2479(DNA-binding transcriptional repressor, regulatory protein accessory to GcvA) BN373_34721(glycine cleavage system transcriptional repressor) t0369(glycine cleavage system transcriptional repressor) SL1344_2453(glycine cleavage system transcriptional repressor) Cluster2403 1 0 1 1 1 1 1 ROD_24101(ethanolamine utilization protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1268(Ethanolamine utilization protein EutS,carboxysome structural protein EutS,Ethanolamine utilization protein,BMC domain) b2462(predicted carboxysome structural protein with predicted role in ethanol utilization) BN373_34551(ethanolamine utilization protein EutS) t0389(putative ethanolamine utilization protein EutS) SL1344_2433(putative ethanolamine utilization protein EutS) Cluster2404 1 0 1 1 1 1 1 ROD_24091(ethanolamine utilization protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1269(ethanolamine utilization protein EutP,ethanolamine utilization protein, EutP,Ethanolamine utilisation - propanediol utilisation) b2461(conserved protein with nucleoside triphosphate hydrolase domain) BN373_34541(ethanolamine utilization protein, EutP) t0390(putative ethanolamine utilization protein EutP) SL1344_2432(putative ethanolamine utilization protein EutP) Cluster2405 1 0 1 1 1 1 1 ROD_24081(ethanolamine utilization protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1270(Ethanolamine utilization protein eutQ,ethanolamine utilization protein EutQ,Ethanolamine utilization protein,Ethanolamine utilisation protein EutQ) b2460(conserved protein) BN373_34531(ethanolamine utilization protein EutQ) t0391(putative ethanolamine utilization protein EutQ) SL1344_2431(putative ethanolamine utilization protein EutQ) Cluster2406 1 0 1 1 1 1 1 ROD_24071(ethanolamine utilization cobalamin adenosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1271(ethanolamine utilization cobalamin adenosyltransferase,Ethanolamine utilization cobalamin adenosyltransferase,Cobalamin adenosyltransferase) b2459(cobalamin adenosyltransferase involved in ethanolamine utilization) BN373_34521(cob(I)yrinic acid a,c-diamide adenosyltransferase) t0392(putative cobalamin adenosyltransferase) SL1344_2430(putative cobalamin adenosyltransferase) Cluster2407 1 0 1 1 1 1 1 ROD_24061(ethanolamine utilization protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1272(Ethanolamine utilization protein eutD,phosphotransacetylase,phosphate acetyltransferase,Phosphate acetyl/butaryl transferase) b2458(phosphate acetyltransferase) BN373_34511(ethanolamine utilization protein EutD) t0393(putative phosphate acyltransferase) SL1344_2429(putative phosphate acyltransferase) Cluster2408 1 0 1 1 1 1 1 ROD_24041(ethanolamine utilization protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1274(Ethanolamine utilization protein eutN,ethanolamine catabolic microcompartment shell protein EutN,Carbon dioxide concentrating mechanism/carboxysome shell protein,carboxysome peptide A,Ethanolamine utilisation protein EutN/carboxysome) b2456(Ethanolamine catabolic microcompartment shell protein) BN373_34491(ethanolamine utilization protein) t0394(putative ethanolamine utilization protein EutN) SL1344_2427(ethanolamine utilization protein) Cluster2409 1 0 1 1 1 1 1 ROD_24031(ethanolamine utilization aldehyde dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1275(Aldehyde-alcohol dehydrogenase,aldehyde dehydrogenase EutE,Delta 1-pyrroline-5-carboxylate dehydrogenase,acetaldehyde dehydrogenase (acetylating),Aldehyde dehydrogenase family) b2455(aldehyde oxidoreductase, ethanolamine utilization protein) BN373_34481(ethanolamine utilization protein EutE) t0395(putative aldehyde dehydrogenase) SL1344_2426(putative aldehyde dehydrogenase) Cluster2410 1 0 1 1 1 1 1 ROD_24021(ethanolamine utilization protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1276(Cell division protein FtsA,ethanolamine utilization protein EutJ,Ethanolamine utilization protein, possible chaperonin,ethanolamine utilization protein EutJ family protein,Competence protein A) b2454(predicted chaperonin, ethanolamine utilization protein) BN373_34471(ethanolamine utilization protein EutJ) t0396(putative ethanolamine utilization protein EutJ) SL1344_2425(putative ethanolamine utilization protein EutJ) Cluster2411 1 0 1 1 1 1 1 ROD_24011(ethanolamine utilization dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1277(Ethanolamine utilization protein EutG,ethanol dehydrogenase EutG,Glycerol dehydrogenase and related enzymes,lactaldehyde reductase,Iron-containing alcohol dehydrogenase) b2453(ethanol dehydrogenase involved in ethanolamine utilization; aldehyde reductase, converts acetaldehyde to ethanol) BN373_34461(ethanolamine utilization protein EutG) t0397(putative alchohol dehydrogenase) SL1344_2424(putative alchohol dehydrogenase) Cluster2412 1 0 1 1 1 1 1 ROD_24001(putative ethanolamine transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1278(ethanolamine utilization protein EutH,Ethanolamine utilisation protein, EutH) b2452(ethanolamine transporter) BN373_34451(ethanolamine utilization protein EutH) t0398(putative membrane protein) SL1344_2423(putative membrane protein) Cluster2413 1 0 1 1 1 1 1 ROD_23991(ethanolamine utilization protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1279(reactivating factor for ethanolamine ammonia lyase,Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition,Ethanolamine utilisation protein EutA) b2451(reactivating factor for ethanolamine ammonia lyase) BN373_34441(ethanolamine utilization protein EutA) t0399(putative ethanolamine utilization protein EutA) SL1344_2422(putative ethanolamine utilization protein EutA) Cluster2414 1 0 1 1 1 1 1 ROD_23981(ethanolamine ammonia-lyase heavy chain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1280(Ethanolamine ammonia-lyase heavy chain,ethanolamine ammonia lyase large subunit,Ethanolamine ammonia-lyase, large subunit,Ethanolamine ammonia lyase large subunit (EutB)) b2441(ethanolamine ammonia-lyase, large subunit, heavy chain) BN373_34431(ethanolamine ammonia-lyase, large subunit) t0400(ethanolamine ammonia-lyase heavy chain) SL1344_2421(ethanolamine ammonia-lyase heavy chain) Cluster2415 1 0 1 1 1 1 1 ROD_23971(Ethanolamine ammonia-lyase light chain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1281(Ethanolamine ammonia-lyase light chain,ethanolamine ammonia-lyase small subunit,Ethanolamine ammonia-lyase, small subunit,Ethanolamine ammonia-lyase light chain (EutC)) b2440(ethanolamine ammonia-lyase, small subunit (light chain)) BN373_34421(ethanolamine ammonia-lyase, light chain) t0401(ethanolamine ammonia-lyase light chain) SL1344_2420(Ethanolamine ammonia-lyase light chain) Cluster2416 1 0 1 1 1 1 1 ROD_23961(ethanolamine utilization protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1282(Ethanolamine utilization protein EutL,ethanolamine utilization protein EutL,Ethanolamine utilization protein,BMC domain) b2439(predicted carboxysome structural protein with predicted role in ethanolamine utilization) BN373_34411(putative ethanolamine utilization protein EutL) t0402(ethanolamine utilization protein EutL) SL1344_2419(ethanolamine utilization protein EutL) Cluster2417 1 0 1 1 1 1 1 ROD_23951(ethanolamine utilization protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1283(Ethanolamine utilization protein EutK precursor,carboxysome structural protein EutK,Carbon dioxide concentrating mechanism/carboxysome shell protein,PduT-like ethanolamine utilization protein,BMC domain) b2438(predicted carboxysome structural protein with predicted role in ethanolamine utilization) BN373_34401(putative ethanolamine utilization protein EutK) t0403(ethanolamine utilization protein EutK) SL1344_2418(ethanolamine utilization protein EutK) Cluster2418 1 0 1 1 1 1 1 ROD_23941(ethanolamine operon transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1284(transcriptional regulator EutR,Adenosine deaminase,Helix-turn-helix domain) b2437(eut operon transcriptional activator, AraC family) BN373_34391(putative transcriptional regulator EutR) t0404(ethanolamine operon transcriptional regulator) SL1344_2417(ethanolamine operon transcriptional regulator) Cluster2419 1 0 1 1 1 1 1 ROD_23931(coproporphyrinogen III oxidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1285(Coproporphyrinogen-III oxidase, aerobic,coproporphyrinogen III oxidase,Coproporphyrinogen III oxidase) b2436(coproporphyrinogen III oxidase) BN373_34381(coproporphyrinogen III oxidase, aerobic) t0407(coproporphyrinogen III oxidase) SL1344_2414(Coproporphyrinogen III oxidase, aerobic) Cluster2420 1 0 1 1 1 1 1 ROD_23851(sulphate ABC transporter, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1295(Sulfate transport system permease protein CysW,sulfate/thiosulfate transporter subunit,ABC-type sulfate transport system, permease component,sulfate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component) b2424(sulfate/thiosulfate ABC transporter permease) BN373_34311(sulfate ABC transporter, permease protein CysT) t0415(sulphate transport system permease protein CysT) SL1344_2406(sulphate transport system permease protein CysT) Cluster2421 1 0 1 1 1 1 1 ROD_23831(sulphate ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1297(Sulfate/thiosulfate import ATP-binding protein CysA,sulfate/thiosulfate transporter subunit,ABC-type spermidine/putrescine transport systems, ATPase components,sulfate ABC transporter, ATP-binding protein,ABC transporter) b2422(sulfate/thiosulfate transporter subunit) BN373_34291(sulfate ABC transporter, ATP-binding protein) t0417(sulphate transport ATP-binding protein CysA) SL1344_2404(sulphate transport ATP-binding protein CysA) Cluster2422 1 0 1 1 1 1 1 ROD_23821(cysteine synthase B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1298(Cysteine synthase B,cysteine synthase B,Cysteine synthase,cysteine synthase B,Pyridoxal-phosphate dependent enzyme) b2421(cysteine synthase B (O-acetylserine sulfhydrolase B)) BN373_34281(cysteine synthase B) t0418(cysteine synthase B) SL1344_2403(cysteine synthase B) Cluster2423 1 0 1 1 1 1 1 ROD_23701(DNA ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1307(DNA ligase,NAD-dependent DNA ligase LigA,3-methyladenine DNA glycosylase,DNA ligase, NAD-dependent,NAD-dependent DNA ligase adenylation domain) b2411(DNA ligase, NAD(+)-dependent) BN373_34161(DNA ligase, NAD-dependent) t0431(DNA ligase) SL1344_2390(DNA ligase) Cluster2424 1 0 1 1 1 1 1 ROD_23691(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1308(DNA polymerase III subunit epsilon,Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF3820)) b4546(predicted protein) BN373_34151(conserved hypothetical protein) t0430(conserved hypothetical protein) SL1344_2389(conserved hypothetical protein) Cluster2425 1 0 1 1 1 1 1 ROD_28171(putative regulatory protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1320(DNA binding domain, excisionase family,Putative transcription regulator (DUF1323)) b2399(conserved protein, DUF1323 family; N-terminal HTH domain of the MerR superfamily) BN373_34111(conserved hypothetical protein) t0443(conserved hypothetical protein) SL1344_2380(conserved hypothetical protein) Cluster2426 1 0 1 1 1 1 1 ROD_28111(manganese transport protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1325(Manganese transport protein MntH,manganese transport protein MntH,Mn2+ and Fe2+ transporters of the NRAMP family,metal ion transporter, metal ion (Mn2+/Fe2+) transporter (Nramp) family,Natural resistance-associated macrophage protein) b2392(manganese/divalent cation transporter) BN373_34071(manganese transport protein MntH) t0449(manganese transport protein MntH) SL1344_2376(Probable manganese transport protein mntH) Cluster2427 0 2 1 2 1 0 0 ENC_24350(Predicted transcriptional regulator with C-terminal CBS domains),ENC_24360(SOS-response transcriptional repressors (RecA-mediated autopeptidases)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2573(Uncharacterized HTH-type transcriptional regulator CBU_1416,transcriptional repressor DicA,putative zinc finger/helix-turn-helix protein, YgiT family,Helix-turn-helix) b1145(e14 prophage; repressor protein phage e14),b1570(Qin prophage; predicted regulator for DicB) BN373_33841(putative phage repressor) Cluster2428 1 0 2 2 1 0 0 ROD_26171(hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1803(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2570(hypothetical protein) pseudob2358(unknown),pseudob4692(unknown) BN373_33811(conserved hypothetical protein) Cluster2429 1 0 1 1 1 1 1 ROD_27421(putative methylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1381(50S ribosomal protein L3 glutamine methyltransferase,N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase,Methylase of polypeptide chain release factors,protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific,Methyltransferase small domain) b2330(N5-glutamine methyltransferase) BN373_33301(ribosomal large subunit L3 protein glutamine methyltransferase) t0479(conserved hypothetical protein) SL1344_2354(conserved hypothetical protein) Cluster2430 1 1 1 1 1 0 1 ROD_27381(conserved hypothetical protein) ENC_38810(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1385(Protein of unknown function, DUF462) b2326(conserved protein) BN373_33261(conserved hypothetical protein) SL1344_2350(conserved hypothetical protein) Cluster2431 1 0 1 1 1 1 1 ROD_27371(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1386(YfcL protein) b2325(predicted protein) BN373_33251(conserved hypothetical protein) t0484(conserved hypothetical protein) SL1344_2349(conserved hypothetical protein) Cluster2432 1 0 1 1 1 1 1 ROD_27361(putative oxidoreductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1387(tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC,bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase,Uncharacterized conserved protein,tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain,Protein of unknown function (DUF752)) b2324(fused 5-methylaminomethyl-2-thiouridine-forming enzyme methyltransferase and FAD-dependent demodification enzyme) BN373_33241(tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC) t0485(conserved hypothetical protein) SL1344_2348(conserved hypothetical protein) Cluster2433 1 0 1 1 1 1 1 ROD_27321(erythronate-4-phosphate dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1391(Erythronate-4-phosphate dehydrogenase,erythronate-4-phosphate dehydrogenase PdxB,Phosphoserine aminotransferase,phosphoglycerate dehydrogenase,D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain) b2320(erythronate-4-phosphate dehydrogenase) BN373_33201(erythronate-4-phosphate dehydrogenase) t0494(erythronate-4-phosphate dehydrogenase) SL1344_2339(Erythronate-4-phosphate dehydrogenase) Cluster2434 1 0 1 1 1 1 1 ROD_27261(putative peptidoglycan-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1397(cell division protein DedD,Uncharacterized protein conserved in bacteria,Sporulation related domain) b2314(membrane-anchored periplasmic protein involved in septation) BN373_33141(cell division protein DedD) t0500(DedD protein) SL1344_2333(DedD protein) Cluster2435 1 0 1 1 1 1 1 ROD_27231(amidophosphoribosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1399(Amidophosphoribosyltransferase,amidophosphoribosy ltransferase,Glutamine phosphoribosylpyrophosphate amidotransferase,amidophosphoribosyltransferase,Glutamine amidotransferases class-II) b2312(amidophosphoribosyltransferase) BN373_33121(amidophosphoribosyltransferase) t0502(amidophosphoribosyltransferase) SL1344_2331(amidophosphoribosyltransferase) Cluster2436 1 0 1 1 1 1 1 ROD_27151(histidine ABC transporter, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1404(Histidine transport system permease protein hisM,histidine/lysine/arginine/ornithine ABC transporter permease HisM,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component) b2307(histidine/lysine/arginine/ornithine transporter subunit) BN373_33071(histidine ABC transporter, permease protein HisM) t0512(histidine transport system permease) SL1344_2321(histidine transport system permease) Cluster2437 1 0 1 1 1 1 1 ROD_26951(putative phosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1417(Phosphatase YfbT,putative phosphatase,beta-phosphoglucomutase family hydrolase,haloacid dehalogenase-like hydrolase) b2293(sugar phosphatas) BN373_32941(sugar-phosphatase, YfbT) t0530(putative phosphatase) SL1344_2303(putative phosphatase) Cluster2438 1 0 1 1 1 1 1 ROD_26941(putative transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1418(Na(+)/dicarboxylate symporter,Uncharacterized conserved protein,transporter, divalent anion:Na+ symporter (DASS) family,Citrate transporter) b2292(predicted transporter) BN373_32931(transporter, divalent anion:Na+ symporter (DASS) family) t0531(putative sodium/sulphate transporter) SL1344_2302(putative sodium/sulphate transporter) Cluster2439 1 0 1 1 1 1 1 ROD_26901(NADH-quinone oxidoreductase subunit A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1423(NAD(P)H-quinone oxidoreductase subunit 3,NADH:ubiquinone oxidoreductase subunit A,NADH:ubiquinone oxidoreductase subunit 3 (chain A),NADH-ubiquinone/plastoquinone oxidoreductase, chain 3) b2288(NADH:ubiquinone oxidoreductase, membrane subunit A) BN373_32891(NADH-quinone oxidoreductase, A subunit) t0536(NADH dehydrogenase I chain A) SL1344_2297(NADH dehydrogenase I chain A) Cluster2440 1 0 1 1 1 1 1 ROD_26721(menaquinone-specific isochorismate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1442(Menaquinone-specific isochorismate synthase,menaquinone-specific isochorismate synthase,Anthranilate/para-aminobenzoate synthases component I,isochorismate synthase,chorismate binding enzyme) b2265(isochorismate synthase 2) BN373_32741(isochorismate synthase, menaquinone-specific) t0553(isochorismate synthase) SL1344_2279(isochorismate synthase) Cluster2441 1 0 1 1 1 1 1 ROD_26701(acyl-CoA thioester hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1444(2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxy late synthase,2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxyl ate synthase,2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxyl ate synthase,Alpha/beta hydrolase family) b2263(2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase) BN373_32721(hydrolase, alpha/beta fold family) t0555(conserved hypothetical protein) SL1344_2277(conserved hypothetical protein) Cluster2442 1 0 1 1 1 1 1 ROD_26651(NUDIX-family hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1457(Nucleoside triphosphatase nudI,nucleoside triphosphatase NudI,NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding,mutator mutT protein,NUDIX domain) b2251(nucleoside triphosphatase) BN373_32681(pyrimidine deoxynucleoside triphosphate pyrophosphohydrolase) t0568(conserved hypothetical protein) SL1344_2264(conserved hypothetical protein) Cluster2443 1 0 1 1 1 1 1 ROD_26611(putative transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1460(Uncharacterized HTH-type transcriptional regulator RhmR,DNA-binding transcriptional regulator KdgR,beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family,Bacterial transcriptional regulator) b2248(predicted DNA-binding transcriptional regulator for the rhm operon) BN373_32641(transcriptional regulator, IclR family) t0571(putative transcriptional regulator) SL1344_2261(putative transcriptional regulator) Cluster2444 1 0 1 1 1 1 1 ROD_26601(putative MR-MLE-family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1461(L-rhamnonate dehydratase,L-rhamnonate dehydratase,L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily,muconate and chloromuconate cycloisomerases,Mandelate racemase / muconate lactonizing enzyme, C-terminal domain) b2247(L-rhamnonate dehydratase) BN373_32631(mandelate racemase/muconate lactonizing enzyme family protein) t0572(putative MR-MLE-family protein) SL1344_2260(putative MR-MLE-family protein) Cluster2445 1 0 1 1 1 1 1 ROD_26591(major facilitator superfamily protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1462(Inner membrane transport protein RhmT,putative 3-hydroxyphenylpropionic transporter MhpT,Splicing factor (branch point binding protein),D-galactonate transporter,Major Facilitator Superfamily) b2246(predicted L-rhamnonate transporter) BN373_32621(transporter, major facilitator family) t0573(putative transport protein) SL1344_2259(putative transport protein) Cluster2446 1 0 1 1 1 1 1 ROD_26581(putative carbon-carbon lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1463(2-keto-3-deoxy-L-rhamnonate aldolase,2-keto-3-deoxy-L-rhamnonate aldolase,2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase,HpcH/HpaI aldolase/citrate lyase family) b2245(2-keto-3-deoxy-L-rhamnonate aldolase) BN373_32611(putative 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase) t0574(putative 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase) SL1344_2258(putative 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase) Cluster2447 1 0 1 1 1 1 1 ROD_23571(putative ferredoxin) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1472(CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydr ase reductase,2Fe-2S ferredoxin YfaE,Uncharacterized Fe-S protein,2Fe-2S iron-sulfur cluster binding domain) b2236(ferredoxin involved with ribonucleotide reductase diferric-tyrosyl radical (Y*) cofactor maintenance) BN373_32551(2Fe-2S iron-sulfur cluster-binding protein) t0585(putative ferredoxin) SL1344_2248(putative ferredoxin) Cluster2448 1 0 1 1 1 1 1 ROD_23551(ribonucleoside-diphosphate reductase 1 alpha chain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1474(Ribonucleoside-diphosphate reductase 1 subunit alpha,ribonucleotide-diphosphate reductase subunit alpha,ribonucleoside-diphosphate reductase, alpha subunit,Ribonucleotide reductase, barrel domain) b2234(ribonucleoside-diphosphate reductase 1, alpha subunit) BN373_32531(ribonucleoside-diphosphate reductase, alpha subunit) t0587(ribonucleoside-diphosphate reductase 1 alpha chain) SL1344_2246(ribonucleoside-diphosphate reductase 1 alpha chain) Cluster2449 1 0 1 1 1 1 1 ROD_23541(3-demethylubiquinone-9 3-methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1476(3-demethylubiquinone-9 3-methyltransferase,bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase,Predicted methyltransferase (contains TPR repeat),3-demethylubiquinone-9 3-O-methyltransferase,Methyltransferase domain) b2232(bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase) BN373_32521(3-demethylubiquinone-9 3-O-methyltransferase) t0588(3-demethylubiquinone-9 3-methyltransferase) SL1344_2245(3-demethylubiquinone-9 3-methyltransferase) Cluster2450 1 0 1 1 1 1 1 ROD_23521(two-component system response regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1489(Sensor kinase protein RcsC,hybrid sensory kinase in two-component regulatory system with RcsB and YojN,Uncharacterized domain of BarA-like signal transduction histidine kinases,TMAO reductase sytem sensor TorS,RcsC Alpha-Beta-Loop (ABL)) b2218(hybrid sensory kinase in two-component regulatory system with RcsB and YojN) BN373_32441(sensor kinase protein RcsC) t0594(sensor protein RcsC) SL1344_2240(sensor protein RcsC) Cluster2451 1 0 1 1 1 1 1 ROD_23481(outer membrane protein C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1493(Porin OmpC,outer membrane porin protein C,Outer membrane protein (porin),Gram-negative porin) b2215(outer membrane porin protein C) BN373_32411(outer membrane protein C) t0597(outer membrane protein C) SL1344_2237(outer membrane protein C) Cluster2452 1 0 1 1 1 1 1 ROD_23131(bicyclomycin resistance protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1527(Sulfonamide resistance protein,bicyclomycin/multidrug efflux system,Arabinose efflux permease,drug resistance transporter, Bcr/CflA subfamily,Major Facilitator Superfamily) b2182(bicyclomycin/multidrug efflux system) BN373_32211(bicyclomycin resistance protein) t0633(bicyclomycin resistance protein) SL1344_2198(bicyclomycin resistance protein) Cluster2453 1 0 1 1 1 1 1 ROD_23121(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1528(hypothetical protein) b2181(predicted protein) BN373_32201(conserved hypothetical protein) t0635(conserved hypothetical protein) SL1344_2197(conserved hypothetical protein) Cluster2454 1 0 1 1 1 1 1 ROD_23081(ABC transporter, substrate-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1532(Oligopeptide-binding protein AppA precursor,oligopeptide ABC transporter substrate-binding protein OppA,ABC-type oligopeptide transport system, periplasmic component,nickel ABC transporter, nickel/metallophore periplasmic binding protein,Bacterial extracellular solute-binding proteins, family 5 Middle) b2177(microcin C transporter YejABEF, periplasmic binding protein; ABC family) BN373_32161(ABC transporter, periplasmic substrate-binding protein) t0639(putative transport system periplasmic binding protein) SL1344_2193(putative transport system periplasmic binding protein) Cluster2455 1 0 1 1 1 1 1 ROD_23041(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1536(Uncharacterized GTP-binding protein YjiA,putative GTP-binding protein YjiA,cobalamin biosynthesis protein CobW,CobW/HypB/UreG, nucleotide-binding domain) b2173(predicted enzyme) BN373_32121(CobW/P47K family protein) t0643(conserved hypothetical protein) SL1344_2189(conserved hypothetical protein) Cluster2456 1 0 1 1 1 1 1 ROD_22991(Elongation factor P-like protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1538(Elongation factor P-like protein,elongation factor P,elongation factor P-like protein YeiP,Elongation factor P, C-terminal) b2171(elongation factor P-like protein) BN373_32091(elongation factor P-like protein YeiP) t0644(hypothetical protein) SL1344_2188(elongation factor p-like protein) Cluster2457 1 1 1 1 1 0 1 ROD_22981(conserved hypothetical protein) ENC_40020(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1539(Flagellin N-methylase) b4502(conserved protein, UPF0153 family) BN373_32081(conserved hypothetical protein) SL1344_2187(conserved hypothetical protein) Cluster2458 1 0 1 1 1 1 1 ROD_22891(Probable endonuclease IV) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1550(Endonuclease 4,endonuclease IV,Endonuclease IV,apurinic endonuclease (APN1),Xylose isomerase-like TIM barrel) b2159(endonuclease IV with intrinsic 3'-5' exonuclease activity) BN373_32011(endonuclease 4) t0652(endonuclease IV) SL1344_2180(Probable endonuclease IV) Cluster2459 1 1 1 1 1 0 1 ROD_22761(galactose/methyl galactoside ABC transporter, ATP-binding protein) ENC_40200(glucose ABC transporter ATP-binding protein/galactose ABC transporter ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1560(Galactose/methyl galactoside import ATP-binding protein MglA,galactose/methyl galaxtoside transporter ATP-binding protein,Predicted periplasmic lipoprotein,D-xylose ABC transporter, ATP-binding protein,ABC transporter) b2149(fused methyl-galactoside transporter subunits of ABC superfamily: ATP-binding components) BN373_31891(galactose ABC transporter, ATP-binding protein) SL1344_2166(galactoside transport atp-binding protein mgla) Cluster2460 1 0 1 1 1 1 1 ROD_22721(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1565(vancomycin high temperature exclusion protein,Cytidine deaminase,DUF218 domain) b2144(vancomycin high temperature exclusion protein; mutants have a defective envelope more permeable to vancomycin at 42 degrees) BN373_31871(protein SanA) t0671(vancomycin resistance protein) SL1344_2161(vancomycin resistance protein) Cluster2461 1 0 1 1 1 1 1 ROD_22711(cytidine deaminase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1566(Cytidine deaminase,cytidine deaminase,Cytidine deaminase,cytidine deaminase,Cytidine and deoxycytidylate deaminase zinc-binding region) b2143(cytidine/deoxycytidine deaminase) BN373_31861(cytidine deaminase) t0672(cytidine deaminase) SL1344_2160(cytidine deaminase) Cluster2462 1 1 1 1 1 0 1 ROD_22571(penicillin-binding protein 7) ENC_40320(murein-DD-endopeptidase. Serine peptidase. MEROPS family S11) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1574(D-alanyl-D-alanine endopeptidase precursor,D-alanyl-D-alanine endopeptidase,D-alanyl-D-alanine carboxypeptidase) b2134(D-alanyl-D-alanine endopeptidase) BN373_31751(penicillin-binding protein 7) SL1344_2146(penicillin-binding protein) Cluster2463 1 0 1 1 1 1 1 ROD_22431(ABC transporter permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1578(Putative osmoprotectant uptake system permease protein yehY,glycine betaine transporter membrane protein,ABC-type proline/glycine betaine transport systems, periplasmic components,choline ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component) b2130(predicted transporter subunit: membrane component of ABC superfamily) BN373_31701(ABC transporter, quaternary amine uptake transporter (QAT) family, permease protein) t0692(putative permease transmembrane component) SL1344_2142(putative permease transmembrane component) Cluster2464 1 0 1 1 1 1 1 ROD_22411(ABC transporter, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1580(Putative osmoprotectant uptake system permease protein yehW,glycine betaine transporter membrane protein,ABC-type proline/glycine betaine transport systems, periplasmic components,choline ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component) b2128(predicted transporter subunit: membrane component of ABC superfamily) BN373_31681(ABC transporter, quaternary amine uptake transporter (QAT) family, permease protein) t0693(putative permease transmembrane component) SL1344_2140(putative permease transmembrane component) Cluster2465 1 0 1 1 1 1 1 ROD_22402(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1581(hypothetical protein,hypothetical protein) b4542(predicted protein) BN373_31671(conserved hypothetical protein) t0694(hypothetical protein) SL1344_2139(hypothetical protein) Cluster2466 1 0 1 1 1 1 1 ROD_22271(phosphomethylpyrimidine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1611(Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase,bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase,Thiamine monophosphate synthase,phosphomethylpyrimidine kinase,Phosphomethylpyrimidine kinase) b2103(bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase) BN373_31531(phosphomethylpyrimidine kinase) t0710(phosphomethylpyrimidine kinase) SL1344_2123(phosphomethylpyrimidine kinase) Cluster2467 1 1 1 1 1 0 1 ROD_22151(conserved hypothetical protein) ENC_40840(conserved protein of unknown function cotranscribed with Bmr (bmrU)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1626(Lipid kinase YegS,lipid kinase,lipid kinase YegS,Diacylglycerol kinase catalytic domain) b2086(phosphatidylglycerol kinase, metal-dependent) BN373_31361(diacylglycerol kinase catalytic domain protein) SL1344_2117(conserved hypothetical protein) Cluster2468 1 0 1 1 1 1 1 ROD_22051(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1642(Heat shock protein 70,putative chaperone,chaperone protein DnaK,Hsp70 protein) b2069(predicted chaperone) BN373_31241(conserved hypothetical protein) t0747(conserved hypothetical protein) SL1344_2102(conserved hypothetical protein) Cluster2469 1 0 1 1 1 1 1 ROD_21661(UDP-glucose 6-dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1684(UDP-glucose 6-dehydrogenase,UDP-glucose 6-dehydrogenase,nucleotide sugar dehydrogenase,UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain) b2028(UDP-glucose 6-dehydrogenase) BN373_30991(UDP-glucose 6-dehydrogenase) t0793(UDP-glucose 6-dehydrogenase) SL1344_2057(UDP-glucose 6-dehydrogenase) Cluster2470 1 0 1 1 1 1 1 ROD_41911(UDP-glucose:(galactosyl) LPS alpha-1,2-glucosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.59(Lipopolysaccharide 1,2-glucosyltransferase,lipopolysaccharide 1,3-galactosyltransferase,Glycosyl transferase family 8) b3626(UDP-D-glucose:(galactosyl)lipopolysaccharide glucosyltransferase) BN373_30951(putative glycosyltransferase) t3802(lipopolysaccharide 1,2-glucosyltransferase) SL1344_3683(lipopolysaccharide 1,2-glucosyltransferase) Cluster2471 1 0 0 1 1 1 2 ROD_43331(putative glycosyl transferase) b2351(CPS-53 (KpLE1) prophage; bactoprenol glucosyl transferase) BN373_30871(conserved hypothetical protein) t2305(bactoprenol glucosyltransferase) SL1344_0548(bactoprenol glucosyl transferase),SL1344_4140(putative phage glycosyl transferase) Cluster2472 1 0 1 1 1 1 1 ROD_21021(cobalamin synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1760(cobalamin synthase,cobalamin 5'-phosphate synthase,Cobalamin-5-phosphate synthase) b1992(cobalamin synthase) BN373_30661(cobalamin 5'-phosphate synthase) t0857(cobalamin (5'-phosphate) synthase) SL1344_1993(cobalamin (5'-phosphate) synthase) Cluster2473 1 1 1 1 1 0 1 ROD_20931(shikimate transporter) ENC_41610(metabolite-proton symporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1771(Inner membrane metabolite transport protein yhjE,shikimate transporter,Transposase and inactivated derivatives,MFS transporter, metabolite:H+ symporter (MHS) family protein,Sugar (and other) transporter) b1981(shikimate transporter) BN373_30591(shikimate transporter) SL1344_0213(putative inner membrane protein) Cluster2474 1 0 1 1 1 1 1 ROD_20391(patch repair protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1863(Very short patch repair protein,DNA G:T-mismatch repair endonuclease,DNA mismatch endonuclease Vsr,DNA mismatch endonuclease Vsr) b1960(DNA mismatch endonuclease of very short patch repair) BN373_30101(very short patch repair protein) t0887(patch repair protein) SL1344_1919(patch repair protein) Cluster2475 1 1 1 1 1 0 1 ROD_20371(putative membrane protein) ENC_42070(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1865(Inner membrane protein yedI,hypothetical protein,Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF808)) b1958(conserved inner membrane protein) BN373_30081(conserved hypothetical protein) SL1344_1917(conserved hypothetical integral membrane protein) Cluster2476 1 0 1 1 1 1 1 ROD_20351(cellulose synthesis regulatory protein (signal transduction protein)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1867(Stalked cell differentiation-controlling protein,putative diguanylate cyclase YedQ,Response regulator containing a CheY-like receiver domain and a GGDEF domain,diguanylate cyclase (GGDEF) domain,GGDEF domain) b1956(predicted diguanylate cyclase) BN373_30071(putative diguanylate cyclase YedQ) t0891(putative membrane protein) SL1344_1915(putative membrane protein) Cluster2477 1 0 1 1 1 1 1 ROD_20331(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1870(Protein of unknown function (DUF2525)) b1953(predicted protein) BN373_30061(conserved hypothetical protein) t0893(conserved hypothetical protein) SL1344_1913(conserved hypothetical protein) Cluster2478 1 0 1 1 1 1 1 ROD_19691(response regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1909(Response regulator uvrY,response regulator,Response regulator,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain) b1914(DNA-binding response regulator in two-component regulatory system with BarA) BN373_29951(response regulator UvrY) t0929(invasion response-regulator) SL1344_1877(invasion response-regulator) Cluster2479 1 0 1 1 1 1 1 ROD_19681(UvrABC system protein C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1910(Excinuclease ABC subunit C,excinuclease ABC subunit C,Nuclease subunit of the excinuclease complex,excinuclease ABC subunit C,UvrC Helix-hairpin-helix N-terminal) b1913(excinuclease UvrABC, endonuclease subunit) BN373_29941(excinuclease ABC, C subunit) t0930(excinuclease ABC subunit C) SL1344_1876(UvrABC system protein C) Cluster2480 1 0 1 1 1 1 1 ROD_19671(CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1911(CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase,phosphatidylglycerophosphate synthetase,CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase,CDP-alcohol phosphatidyltransferase) b1912(phosphatidylglycerophosphate synthetase) BN373_29931(CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase) t0931(phosphotidylglycerophosphate synthetase) SL1344_1875(phosphotidylglycerophosphate synthetase) Cluster2481 1 0 1 1 1 1 1 ROD_19491(trehalose phosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1986(Trehalose-phosphate phosphatase,trehalose-6-phosphate phosphatase,Trehalose-6-phosphate synthase,trehalose-phosphatase,Trehalose-phosphatase) b1897(trehalose-6-phosphate phosphatase, biosynthetic) BN373_29791(trehalose-phosphatase) t0948(trehalose phosphatase) SL1344_1863(trehalose phosphatase) Cluster2482 1 0 1 1 1 1 1 ROD_19201(arginyl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2005(Arginine--tRNA ligase,arginyl-tRNA synthetase,Arginyl-tRNA synthetase,arginine--tRNA ligase,tRNA synthetases class I (R)) b1876(arginyl-tRNA synthetase) BN373_29741(arginyl-tRNA synthetase) t0968(arginyl-tRNA synthetase) SL1344_1844(Arginyl-tRNA synthetase) Cluster2483 1 0 1 1 1 1 1 ROD_19181(copper homeostasis protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2007(Copper homeostasis protein CutC,copper homeostasis protein CutC,Uncharacterized protein involved in copper resistance,CutC family) b1874(copper homeostasis protein) BN373_29721(copper homeostasis protein CutC) t0970(putative copper homeostasis protein) SL1344_1842(putative copper homeostasis protein) Cluster2484 0 1 1 1 1 1 1 ENC_06250(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2013(hypothetical protein,hypothetical protein,Protein of unknown function DUF72) b1868(conserved protein, UPF0759 family) BN373_29681(conserved hypothetical protein) t0974(conserved hypothetical protein) SL1344_1838(conserved hypothetical protein) Cluster2485 1 0 1 1 1 1 1 ROD_19071(aspartyl-tRNA synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2015(Aspartate--tRNA ligase,aspartyl-tRNA synthetase,Aspartyl/asparaginyl-tRNA synthetases,aspartate--tRNA ligase,tRNA synthetases class II (D, K and N)) b1866(aspartyl-tRNA synthetase) BN373_29661(aspartyl-tRNA synthetase) t0976(aspartyl-tRNA synthetase) SL1344_1836(Aspartyl-tRNA synthetase) Cluster2486 1 0 1 1 1 1 1 ROD_19021(holliday junction ATP-dependent DNA helicase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2021(Holliday junction ATP-dependent DNA helicase RuvB,Holliday junction DNA helicase RuvB,Holliday junction resolvasome, helicase subunit,Holliday junction DNA helicase RuvB,Holliday junction DNA helicase ruvB N-terminus) b1860(ATP-dependent DNA helicase, component of RuvABC resolvasome) BN373_29611(Holliday junction DNA helicase RuvB) t0983(Holliday junction DNA helicase) SL1344_1828(Holliday junction DNA helicase ruvB) Cluster2487 1 0 1 1 1 1 1 ROD_18991(zinc import ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2025(Zinc import ATP-binding protein ZnuC,high-affinity zinc transporter ATPase,ABC-type spermidine/putrescine transport systems, ATPase components,anchored repeat-type ABC transporter, ATP-binding subunit,ABC transporter) b1858(zinc transporter subunit: ATP-binding component of ABC superfamily) BN373_29591(high-affinity zinc uptake ABC transporter, ATP-binding protein) t0985(high-affinity zinc uptake system ATP-binding protein) SL1344_1826(high-affinity zinc uptake system ATP-binding protein) Cluster2488 1 0 1 1 1 1 1 ROD_18811(DNA polymerase III, theta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2043(DNA polymerase III subunit theta,DNA polymerase III subunit theta,DNA polymerase III, theta subunit) b1842(DNA polymerase III, theta subunit) BN373_29451(DNA polymerase III, theta subunit) t1001(DNA polymerase III theta subunit) SL1344_1810(DNA polymerase III, theta subunit) Cluster2489 1 0 1 1 1 1 1 ROD_08881(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3121(hypothetical protein,Protein of unknown function (DUF535)) b0877(conserved protein) BN373_29401(putative enzyme) t1993(putative virK protein) SL1344_0879(putative virK protein) Cluster2490 0 1 1 1 1 1 1 ENC_06570(Calcineurin-like phosphoesterase.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2049(Serine/threonine-protein phosphatase 1,serine/threonine protein phosphatase 1,Predicted kinase,bis(5'-nucleosyl)-tetraphosphatase (symmetrical),Calcineurin-like phosphoesterase) b1838(serine/threonine-specific protein phosphatase 1) BN373_29391(serine/threonine-protein phosphatase 1) t1025(serine/threonine protein phosphatase 1) SL1344_1782(serine/threonine protein phosphatase 1) Cluster2491 1 0 1 1 1 1 1 ROD_18771(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2050(Protein of unknown function (DUF1482)) b1837(predicted protein) BN373_29381(conserved hypothetical protein) t1026(putative secreted protein) SL1344_1781(putative secreted protein) Cluster2492 1 0 1 1 1 1 1 ROD_18761(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2051(Protein of unknown function (DUF1480)) b1836(predicted protein) BN373_29371(conserved hypothetical protein) t1027(conserved hypothetical protein) SL1344_1780(conserved hypothetical protein) Cluster2493 1 0 1 1 1 1 1 ROD_18741(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2053(hypothetical protein,paraquat-inducible protein B,virulence factor Mce family protein,mce related protein) b1834(conserved protein) BN373_29351(mce-related protein) t1029(conserved hypothetical protein) SL1344_1778(conserved hypothetical protein) Cluster2494 1 1 1 1 1 0 1 ROD_18681(major facilitator superfamily protein) ENC_06670(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2059(Spectinomycin tetracycline efflux pump,putative transporter,Arabinose efflux permease,drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family,Major Facilitator Superfamily) b1828(predicted transporter) BN373_29291(transporter, major facilitator family) SL1344_1772(putative membrane transport protein) Cluster2495 1 0 1 1 1 1 1 ROD_18641(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2062(hypothetical protein) b1825(predicted inner membrane protein) BN373_29251(conserved hypothetical protein) t1039(putative exported protein) SL1344_1768(putative exported protein) Cluster2496 1 1 0 1 1 1 1 ROD_18621(cold shock-like protein CspC) ENC_06720(Cold shock proteins) b1823(stress protein, member of the CspA-family) BN373_29241(cold shock protein CspC) t1041(cold shock-like protein CspC) SL1344_1766(cold shock-like protein CspC) Cluster2497 1 0 1 1 1 1 1 ROD_18541(putative transport protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2070(hypothetical protein,magnesium/cobalt efflux protein CorC,Putative Mg2+ and Co2+ transporter CorB,gliding motility-associated protein GldE,Integral membrane protein TerC family) b1816(fused predicted membrane protein/conserved protein) BN373_29151(membrane protein, TerC family/CBS/transporter associated domain protein) t1049(putative membrane protein) SL1344_1757(putative membrane protein) Cluster2498 1 0 1 1 1 1 1 ROD_18511(NUDIX-family hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2073(putative NUDIX hydrolase,Cobalamin biosynthesis protein CobD/CbiB,NUDIX domain) b1813(predicted NUDIX hydrolase) BN373_29121(hydrolase, NUDIX family) t1052(conserved hypothetical protein) SL1344_1754(conserved hypothetical protein) Cluster2499 1 0 1 1 1 1 1 ROD_18471(putative ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2078(Probable ATP-dependent helicase dinG homolog,bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon,putative DnaQ family exonuclease/DinG family helicase,Type III restriction enzyme, res subunit) b1808(conserved protein with nucleoside triphosphate hydrolase domain) BN373_29081(conserved hypothetical protein) t1056(putative ATP-dependent helicase) SL1344_1750(putative ATP-dependent helicase) Cluster2500 1 0 1 1 1 1 1 ROD_18331(Disulfide bond formation protein B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2698(Disulfide oxidoreductase,disulfide bond formation protein B,Disulfide bond formation protein DsbB) b1185(oxidoreductase that catalyzes reoxidation of DsbA protein disulfide isomerase I) BN373_28961(disulfide bond formation protein DsbB) t1070(disulfide bond formation protein B) SL1344_1735(Disulfide bond formation protein B) Cluster2501 1 0 1 1 1 1 1 ROD_18321(Na(+)/H(+) antiporter 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2697(Sodium/proton antiporter nhaB,sodium/proton antiporter,Na+/H+ antiporter,Na+/H+ antiporter NhaB,Bacterial Na+/H+ antiporter B (NhaB)) b1186(sodium:proton antiporter) BN373_28951(Na+/H+ antiporter NhaB) t1071(regulator of intracellular pH) SL1344_1734(regulator of intracellular pH; Na+/H+ antiporter) Cluster2502 1 1 1 1 1 0 1 ROD_47611(threonine/serine transporter) ENC_33670(serine transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.574(H(+)/threonine-serine symporter,threonine/serine transporter TdcC,serine transporter,Tryptophan/tyrosine permease family) b3116(L-threonine/L-serine transporter) BN373_28731(threonine/serine transporter) SL1344_3215(threonine/serine transporter) Cluster2503 1 0 1 1 1 1 1 ROD_20971(LysR-family transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4069(Quorum-sensing regulator protein D,cell density-dependent motility repressor,pca operon transcription factor PcaQ,LysR substrate binding domain) b4327(Cell density-dependent motility repressor) BN373_28651(transcriptional regulator, LysR family) t4561(probable transcriptional activator) SL1344_4442(probable transcriptional activator) Cluster2504 1 1 1 0 1 1 1 ROD_06871(citrate-proton symporter) ENC_41910(metabolite-proton symporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4536(Alpha-ketoglutarate permease,citrate-proton symporter,Arabinose efflux permease,MFS transporter, metabolite:H+ symporter (MHS) family protein,Sugar (and other) transporter) BN373_28611(citrate:proton symporter) t2186(citrate-proton symporter) SL1344_0671(citrate-proton symporter) Cluster2505 1 0 1 1 1 1 1 ROD_18091(Peptidyl-tRNA hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2642(Peptidyl-tRNA hydrolase,peptidyl-tRNA hydrolase,Peptidyl-tRNA hydrolase,peptidyl-tRNA hydrolase,Peptidyl-tRNA hydrolase) b1204(peptidyl-tRNA hydrolase) BN373_28361(peptidyl-tRNA hydrolase) t1093(peptidyl-tRNA hydrolase) SL1344_1711(Peptidyl-tRNA hydrolase) Cluster2506 1 0 1 1 1 1 1 ROD_18071(putative sulphate transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2640(Putative sulfate transporter ychM,putative transporter,Permeases,sulfate permease,Sulfate transporter family) b1206(predicted transporter) BN373_28331(sulfate permease, SulP family) t1095(putative sulphate transporter) SL1344_1709(putative sulphate transporter) Cluster2507 1 0 1 1 1 1 1 ROD_18051(4-diphosphocytidyl-2-C-methyl-D-erythritol kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2638(4-diphosphocytidyl-2-C-methyl-D-erythritol kinase,4-diphosphocytidyl-2-C-methyl-D-erythritol kinase,4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase,GHMP kinases N terminal domain) b1208(4-diphosphocytidyl-2-C-methylerythritol kinase) BN373_28311(4-diphosphocytidyl-2C-methyl-D-erythritol kinase) t1097(isopentenyl monophosphate kinase) SL1344_1707(4-diphosphocytidyl-2-C-methyl-D-erythritol kinase) Cluster2508 1 0 1 1 1 1 1 ROD_18021(peptide chain release factor 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2635(Peptide chain release factor 1,peptide chain release factor 1,peptide chain release factor 1,PCRF domain) b1211(peptide chain release factor RF-1) BN373_28281(peptide chain release factor 1) t1100(peptide chain release factor 1) SL1344_1704(peptide chain release factor 1 (RF-1)) Cluster2509 1 0 1 1 1 1 1 ROD_17981(2-dehydro-3-deoxyphosphooctonate aldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2631(2-dehydro-3-deoxyphosphooctonate aldolase,2-dehydro-3-deoxyphosphooctonate aldolase,3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase,3-deoxy-8-phosphooctulonate synthase,DAHP synthetase I family) b1215(3-deoxy-D-manno-octulosonate 8-phosphate synthase) BN373_28241(3-deoxy-8-phosphooctulonate synthase) t1104(2-dehydro-3-deoxyphosphooctonate aldolase) SL1344_1700(2-dehydro-3-deoxyphosphooctonate aldolase) Cluster2510 1 0 1 1 1 1 1 ROD_17861(intimin-like protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2624(Invasin,putative invasin,Protein of unknown function (DUF3442)) b1220(predicted invasin) BN373_28121(intimin/invasin family protein) t1677(putative invasin) SL1344_1696(putative invasin) Cluster2511 1 0 1 1 1 1 1 ROD_17841(nitrate/nitrite two-component sensor kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2622(Nitrate/nitrite sensor protein narX,nitrate/nitrite sensor protein NarX,Signal transduction histidine kinase, nitrate/nitrite-specific,Histidine kinase) b1222(sensory histidine kinase in two-component regulatory system with NarL) BN373_28101(nitrate/nitrite sensor protein NarX) t1676(nitrate/nitrite sensor protein NarX) SL1344_1694(nitrate/nitrite sensor protein NarX) Cluster2512 1 0 1 1 1 1 1 ROD_17671(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2598(hypothetical protein,hypothetical protein,membrane protein, MarC family,MarC family integral membrane protein) b1242(predicted inner membrane protein) BN373_27941(integral membrane protein, MarC family) t1659(putative membrane protein) SL1344_1679(putative membrane protein) Cluster2513 1 1 1 1 1 0 1 ROD_17631(oligopeptide ABC transporter, permease protein) ENC_08020(ABC-type dipeptide/oligopeptide/nickel transport systems, permease components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2593(Oligopeptide transport system permease protein oppC,oligopeptide ABC transporter permease OppC,ABC-type antimicrobial peptide transport system, permease component,nickel ABC transporter, permease subunit NikC,Binding-protein-dependent transport system inner membrane component) b1245(oligopeptide transporter subunit) BN373_27911(oligopeptide ABC transporter, permease protein OppC) SL1344_1675(oligopeptide transport system permease protein (OppC)) Cluster2514 1 0 1 1 1 1 1 ROD_11151(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2860(hypothetical protein,hypothetical protein,Uncharacterized conserved protein,YceI-like domain) b1056(secreted protein) BN373_27841(conserved hypothetical protein) t1763(putative exported protein) SL1344_1094(Hypothetical UPF0312 protein precursor) Cluster2515 1 0 1 1 1 1 1 ROD_17571(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2587(hypothetical protein,YciI-like protein,YCII-related domain) b1251(predicted enzyme) BN373_27831(YciL domain protein) t1650(conserved hypothetical protein) SL1344_1669(conserved hypothetical protein) Cluster2516 1 0 1 1 1 1 1 ROD_13381(translation initiation factor if-3) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2161(Translation initiation factor IF-3,translation initiation factor IF-3,Translation initiation factor 3 (IF-3),translation initiation factor IF-3,Translation initiation factor IF-3, C-terminal domain) b1718(protein chain initiation factor IF-3) BN373_27651(translation initiation factor IF-3) t1214(translation initiation factor IF-3) SL1344_1268(translation initiation factor IF-3) Cluster2517 1 0 1 1 1 1 1 ROD_13391(50S ribosomal subunit protein L35) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2162(Ribosomal protein A,50S ribosomal protein L35,Ribosomal protein L35,ribosomal protein L35,Ribosomal protein L35) b1717(50S ribosomal subunit protein L35) BN373_27641(ribosomal protein L35) t1215(50S ribosomal subunit protein L35) SL1344_1269(50S ribosomal protein L35. Chloroplast 50S ribosomal protein L35) Cluster2518 1 1 0 1 1 1 1 ROD_13431(Integration host factor alpha subunit) ENC_14120(integration host factor, alpha subunit) b1712(integration host factor (IHF), DNA-binding protein, alpha subunit) BN373_27601(integration host factor, alpha subunit) t1220(integration host factor alpha-subunit) SL1344_1273(integration host factor alpha-subunit) Cluster2519 1 0 1 1 1 1 1 ROD_13521(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2176(Putative phosphotransferase ydiA,PEP synthetase regulatory protein,Domain of unknown function (DUF299)) b1703(bifunctional regulatory protein: PEP synthase kinase and PEP synthase pyrophosphorylase) BN373_27471(conserved hypothetical protein) t1229(conserved hypothetical protein) SL1344_1282(conserved hypothetical protein) Cluster2520 1 0 1 1 1 1 1 ROD_13541(phosphoenolpyruvate synthase (pyruvate, water dikinase (PEP synthase)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2177(Phosphoenolpyruvate synthase,phosphoenolpyruvate synthase,Uncharacterized protein conserved in bacteria,phosphoenolpyruvate synthase,Pyruvate phosphate dikinase, PEP/pyruvate binding domain) b1702(phosphoenolpyruvate synthase) BN373_27461(phosphoenolpyruvate synthase) t1230(phosphoenolpyruvate synthase) SL1344_1283(phosphoenolpyruvate synthase) Cluster2521 1 0 1 1 1 1 1 ROD_13631(putative FAD-binding oxidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2193(hypothetical protein,glycolate oxidase subunit GlcD,Fe-S oxidoreductase,glycolate oxidase, subunit GlcD,FAD linked oxidases, C-terminal domain) b1687(predicted FAD-linked oxidoreductase) BN373_27441(putative oxidase, FAD-binding) t1233(conserved hypothetical FAD-binding protein) SL1344_1299(conserved hypothetical FAD-binding protein) Cluster2522 1 1 1 1 1 0 1 ROD_13721(putative peptidoglycan-binding protein) ENC_13640(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2203(Probable L,D-transpeptidase YnhG precursor,L,D-transpeptidase,L,D-transpeptidase catalytic domain) b1678(murein L,D-transpeptidase) BN373_27201(LysM domain/ErfK/YbiS/YcfS/YnhG family protein) SL1344_1309(putative exported protein) Cluster2523 1 0 1 1 1 1 1 ROD_14091(major facilitator superfamily protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2221(Inner membrane transport protein ydhC,putative transporter,Arabinose efflux permease,drug resistance transporter, Bcr/CflA subfamily,Major Facilitator Superfamily) b1660(predicted transporter) BN373_25811(drug resistance transporter, Bcr/CflA subfamily) t1296(putative integral membrane transport protein) SL1344_1360(putative integral membrane transport protein) Cluster2524 1 0 1 1 1 1 1 ROD_14141(superoxide dismutase [Fe]) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2226(Superoxide dismutase [Fe],superoxide dismutase,Iron/manganese superoxide dismutases, C-terminal domain) b1656(superoxide dismutase, Fe) BN373_25761(superoxide dismutase (Fe)) t1299(superoxide dismutase) SL1344_1363(superoxide dismutase) Cluster2525 0 1 1 1 1 1 1 ENC_13210(Predicted Fe-S protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2233(Predicted Fe-S protein,Protein of unknown function (DUF1289)) b1648(conserved protein) BN373_25681(conserved hypothetical protein) t1306(conserved hypothetical protein) SL1344_1370(conserved hypothetical protein) Cluster2526 1 0 1 1 1 1 1 ROD_14241(HlyD-family secretion protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2237(Inner membrane protein yiaV precursor,p-hydroxybenzoic acid efflux subunit AaeA,efflux pump membrane protein,HlyD family secretion protein) b1644(predicted membrane fusion protein (MFP) of YdhJK efflux pump) BN373_25641(auxiliary transport protein, membrane fusion protein (MFP) family) t1310(putative HlyD-family protein) SL1344_1374(putative HlyD-family protein) Cluster2527 0 1 1 1 1 1 1 ENC_13160(Protein of unknown function (DUF1656).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2238(Protein of unknown function (DUF1656)) b1643(predicted inner membrane protein) BN373_25631(conserved hypothetical protein) t1311(conserved hypothetical protein) SL1344_1375(conserved hypothetical protein) Cluster2528 1 0 1 1 1 1 1 ROD_14331(tripeptide permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2247(Dipeptide and tripeptide permease A,putative tripeptide transporter permease,amino acid/peptide transporter (Peptide:H+ symporter),POT family) b1634(dipeptide and tripeptide permease A) BN373_25531(tripeptide permease TppB) t1320(putative proton/oligopeptide symporter) SL1344_1384(putative proton/oligopeptide symporter) Cluster2529 1 0 1 1 1 1 1 ROD_14451(putative oxidoreductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2257(Uncharacterized oxidoreductase ydgJ,putative oxidoreductase,Uncharacterized protein conserved in bacteria,Oxidoreductase family, NAD-binding Rossmann fold) b1624(predicted oxidoreductase) BN373_25411(putative oxidoreductase) t1330(putative oxidoreductase) SL1344_1394(putative oxidoreductase) Cluster2530 1 1 1 1 1 0 1 ROD_16171(alcohol dehydrogenase class-III) ENC_11200(Zn-dependent alcohol dehydrogenases, class III) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3615(S-(hydroxymethyl)glutathione dehydrogenase,L-threonine 3-dehydrogenase,Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase,S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase,Alcohol dehydrogenase GroES-like domain) b0356(alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase) BN373_25331(S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase) SL1344_1557(alcohol dehydrogenase class III (ec 1.1.1.1) (glutathione-dependent formaldehyde dehydrogenase) (fdh) (faldh)) Cluster2531 1 1 1 1 1 0 1 ROD_16151(LysR-family transcriptional regulator) ENC_11170(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2394(HTH-type transcriptional regulator AbgR,putative DNA-binding transcriptional regulator,pca operon transcription factor PcaQ,LysR substrate binding domain) b1422(predicted DNA-binding transcriptional regulator) BN373_25311(transcriptional regulator, LysR family) SL1344_1555(putative LysR-family transcriptional regulatory protein) Cluster2532 1 1 1 1 1 0 1 ROD_16111(conserved hypothetical protein) ENC_11160(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2393(Uncharacterized protein conserved in bacteria,Domain of unknown function (DUF1338)) b1423(predicted metalloenzyme) BN373_25281(conserved hypothetical protein) SL1344_1554(conserved hypothetical protein) Cluster2533 1 0 1 1 1 1 1 ROD_16071(ribosomal-protein-serine acetyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2390(Ribosomal-protein-serine acetyltransferase,ribosomal-protein-L7/L12-serine acetyltransferase,pseudaminic acid biosynthesis N-acetyl transferase,Acetyltransferase (GNAT) family) b1427(ribosomal-protein-L7/L12-serine acetyltransferase) BN373_25241(ribosomal-protein-serine acetyltransferase) t1520(ribosomal-protein-serine acetyltransferase) SL1344_1541(ribosomal-protein-serine acetyltransferase) Cluster2534 1 0 1 1 1 1 1 ROD_16001(putative benzoate transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2385(Inner membrane protein ydcO,Uncharacterized protein involved in benzoate metabolism,benzoate transporter,Benzoate membrane transport protein) b1433(inner membrane protein, predicted transporter, function unknown) BN373_25171(benzoate membrane transport protein) t1515(putative benzoate membrane transport protein) SL1344_1536(putative benzoate membrane transport protein) Cluster2535 1 0 1 1 1 1 1 ROD_15901(gamma-aminobutyraldehyde dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2376(Gamma-aminobutyraldehyde dehydrogenase,gamma-aminobutyraldehyde dehydrogenase,Delta 1-pyrroline-5-carboxylate dehydrogenase,1-pyrroline dehydrogenase,Aldehyde dehydrogenase family) b1444(gamma-aminobutyraldehyde dehydrogenase) BN373_25021(gamma-aminobutyraldehyde dehydrogenase) t1506(putative aldehyde dehydrogenase) SL1344_1528(putative aldehyde dehydrogenase) Cluster2536 1 1 1 1 1 0 1 ROD_15891(putative membrane protein) ENC_09350(Protein of unknown function (DUF2566).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2375(Protein of unknown function (DUF2566)) b1445(conserved protein, DUF2566 family) BN373_24971(conserved hypothetical protein) SL1344_1527(putative inner membrane protein) Cluster2537 1 1 0 1 1 1 1 ROD_15811(putative zinc-binding dehydrogenase) ENC_09460(hypothetical protein) b1449(curcumin/dihydrocurcumin reductase, NADPH-dependent) BN373_24891(oxidoreductase, zinc-binding dehydrogenase family) t1499(putative NADP-dependent oxidoreductase) SL1344_1520(putative NADP-dependent oxidoreductase) Cluster2538 1 0 1 1 1 1 1 pseudoROD_06641(pyrimidine-specific ribonucleoside hydrolase (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3350(Pyrimidine-specific ribonucleoside hydrolase rihA,ribonucleoside hydrolase 1,Inosine-uridine preferring nucleoside hydrolase) b0651(ribonucleoside hydrolase 1) BN373_24881(pyrimidine-specific ribonucleoside hydrolase RihA) t2212(probable nucleoside hydrolase) SL1344_0650(probable nucleoside hydrolase) Cluster2539 0 1 1 1 1 1 1 ENC_09510(Gamma-aminobutyrate permease and related permeases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2368(General aromatic amino acid permease,L-asparagine permease,Amino acid transporters,GABA permease,Amino acid permease) b1453(L-asparagine transporter) BN373_24821(L-asparagine permease) t1494(L-asparagine permease) SL1344_1515(L-asparagine permease) Cluster2540 0 1 2 1 1 1 0 ENC_09520(transcriptional regulator, LysR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2437(D-malate degradation protein R,DNA-binding transcriptional activator GcvA,ABC-type uncharacterized transport system, periplasmic component,putative choline sulfate-utilization transcription factor,LysR substrate binding domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3672(D-malate degradation protein R,DNA-binding transcriptional activator GcvA,ABC-type uncharacterized transport system, periplasmic component,putative choline sulfate-utilization transcription factor,LysR substrate binding domain) b1328(predicted DNA-binding transcriptional regulator) BN373_24811(transcriptional regulator, LysR family) t0143(putative LysR-family transcriptional regulator) Cluster2541 1 1 1 1 1 0 1 ROD_15721(respiratory nitrate reductase 2 gamma chain) ENC_09730(respiratory nitrate reductase, gamma subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2362(Respiratory nitrate reductase 2 gamma chain,Nitrate reductase gamma subunit,respiratory nitrate reductase, gamma subunit,Nitrate reductase gamma subunit) b1465(nitrate reductase 2 (NRZ), gamma subunit) BN373_24641(respiratory nitrate reductase 2, gamma subunit) SL1344_1511(respiratory nitrate reductase 2 gamma chain) Cluster2542 1 1 1 1 1 0 1 ROD_15711(respiratory nitrate reductase 2 delta chain) ENC_09740(respiratory nitrate reductase chaperone NarJ) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2361(Redox enzyme maturation protein NarJ,nitrate reductase 2 subunit delta,nitrate reductase molybdenum cofactor assembly chaperone,Nitrate reductase delta subunit) b1466(nitrate reductase 2 (NRZ), delta subunit (assembly subunit)) BN373_24631(nitrate reductase molybdenum cofactor assembly chaperone 2) SL1344_1510(respiratory nitrate reductase 2 delta chain) Cluster2543 1 1 1 1 1 0 1 ROD_15631(putative membrane protein) ENC_09810(EamA-like transporter family.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2357(Aromatic amino acid exporter YddG,aromatic amino acid exporter,carboxylate/amino acid/amine transporter,EamA-like transporter family) b1473(aromatic amino acid exporter) BN373_24491(putative membrane protein) SL1344_1502(putative integral membrane protein) Cluster2544 1 1 1 1 1 0 1 ROD_15611(formate dehydrogenase, nitrate-inducible, iron-sulfur subunit) ENC_09850(formate dehydrogenase beta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2355(Formate dehydrogenase-N subunit beta,hydrogenase 2 protein HybA,Uncharacterized Fe-S center protein,formate dehydrogenase, beta subunit,Formate dehydrogenase N, transmembrane) b1475(formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible) BN373_24461(formate dehydrogenase, nitrate-inducible, iron-sulfur subunit) SL1344_1499(formate dehydrogenase, nitrate-inducible, iron-sulfur subunit (formate dehydrogenase-n beta subunit) (fdh-n beta subunit) (anaerobic formate dehydrogenase iron-sulfur subunit)) Cluster2545 1 1 1 1 1 0 1 ROD_15601(formate dehydrogenase, nitrate-inducible, cytochrome b556(fdn) subunit) ENC_09860(formate dehydrogenase gamma subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2354(Formate dehydrogenase-N subunit gamma,formate dehydrogenase-N subunit gamma,formate dehydrogenase, gamma subunit,Cytochrome b(N-terminal)/b6/petB) b1476(formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible) BN373_24451(formate dehydrogenase, gamma subunit) SL1344_1498(formate dehydrogenase, nitrate-inducible, cytochrome b556(fdn) subunit (formate dehydrogenase-n gamma subunit) (fdh-n gamma subunit) (anaerobic formate dehydrogenase cytochrome b556 subunit)) Cluster2546 1 1 1 1 1 0 1 ROD_04391(major facilitator superfamily protein) ENC_09890(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3586(hypothetical protein,MFS transport protein AraJ,Arabinose efflux permease,multidrug resistance protein,Major Facilitator Superfamily) b0396(arabinose-inducible predicted transporter, MFS family) BN373_24401(putative transporter AraJ) SL1344_0389(transmembrane efflux protein) Cluster2547 1 1 0 1 1 1 1 ROD_14951(putative exported protein) ENC_31100(conserved hypothetical protein TIGR00156) b1536(conserved protein) BN373_24121(conserved hypothetical protein) t1436(putative periplasmic protein) SL1344_1445(putative periplasmic protein) Cluster2548 0 1 1 1 1 1 1 ENC_05270(Acetyltransferase, GNAT family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4372(aminoalkylphosphonic acid N-acetyltransferase,ribosomal-protein-alanine acetyltransferase,Acetyltransferase (GNAT) family) b4093(predicted acyltransferase with acyl-CoA N-acyltransferase domain) BN373_23471(acetyltransferase, GNAT family) t4194(putative acetyltransferase) SL1344_4224(putative acetyltransferase) Cluster2549 1 1 1 0 1 1 1 ROD_27031(PTS system EIIC component) ENC_39110(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4175(Ascorbate-specific PTS system EIIC component,PTS system ascorbate-specific transporter subunit IIC,Phosphotransferase system, galactitol-specific IIB component,PTS system sugar-specific permease component) BN373_23211(PTS system ascorbate-specific transporter subunit IIC) t0522(putative membrane protein) SL1344_2311(putative membrane protein) Cluster2550 1 0 2 1 1 0 1 ROD_37951(fructose-like specific PTS system EIIB component 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.24(EIIBCA-Man,putative PTS system fructose-like transporter subunit EIIB,PTS system, Fru family, IIB component,PTS system, Lactose/Cellobiose specific IIB subunit),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4551(Fructose-like phosphotransferase enzyme IIB component 1,putative PTS system fructose-like transporter subunit EIIB,PTS system, Fru family, IIB component,PTS system, Lactose/Cellobiose specific IIB subunit) b3950(predicted enzyme IIB component of PTS) BN373_23181(PTS system, fructose-specific, IIB subunnit) SL1344_4062(PTS system protein IIB component 1 (phosphotransferase enzyme ii, b component) (ec 2.7.1.69)) Cluster2551 1 1 1 1 1 0 1 ROD_31431(conserved hypothetical protein) ENC_32610(LysM domain./Putative phospholipid-binding domain.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1114(hypothetical protein,LysM domain/BON superfamily protein,LysM domain) b2665(predicted protein) BN373_23001(LysM domain/BON superfamily protein) SL1344_2779(conserved hypothetical protein) Cluster2552 1 0 1 1 1 1 1 ROD_00391(probable crotonobetaine/carnitine-CoA ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3956(Short-chain-fatty-acid--CoA ligase,putative crotonobetaine/carnitine-CoA ligase,Uncharacterized protein conserved in bacteria,O-succinylbenzoate-CoA ligase,AMP-binding enzyme) b0037(probable crotonobetaine/carnitine-CoA ligase) BN373_22781(putative acyl-CoA synthase) t0072(probable crotonobetaine/carnitine-CoA ligase) SL1344_0072(probable crotonobetaine/carnitine-CoA ligase) Cluster2553 1 0 1 1 1 1 1 ROD_48201(major facilitator superfamily protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4064(Protein of unknown function (DUF1228)) b4332(predicted inner membrane protein) BN373_22281(transporter, major facilitator family) t4566(putative membrane protein) SL1344_4446(putative membrane protein) Cluster2554 1 0 1 1 1 1 1 ROD_15101(sugar efflux transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2319(Sugar efflux transporter,putative arabinose transporter,Arabinose efflux permease,multidrug resistance protein,Major Facilitator Superfamily) b1528(predicted arabinose transporter) BN373_21971(sugar efflux transporter SotB) t1443(putative membrane transport protein) SL1344_1452(Probable sugar efflux transporter) Cluster2555 1 0 1 1 1 1 1 ROD_15081(multiple antibiotic resistance regulatory protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2317(Multiple antibiotic resistance protein marR,DNA-binding transcriptional repressor MarR,homoprotocatechuate degradation operon regulator, HpaR,MarR family) b1530(DNA-binding transcriptional repressor of multiple antibiotic resistance) BN373_21941(multiple antibiotic resistance protein MarR) t1441(multiple antibiotic resistance protein MarR) SL1344_1450(multiple antibiotic resistance protein MarR) Cluster2556 1 0 1 1 1 1 1 ROD_15051(probable amino acid metabolite efflux) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2314(Probable amino-acid metabolite efflux pump,O-acetylserine/cysteine export protein,Predicted permease, DMT superfamily,carboxylate/amino acid/amine transporter,EamA-like transporter family) b1533(cysteine and O-acetyl-L-serine efflux system) BN373_21911(transporter, 10 TMS drug/metabolite exporter (DME) family) t1438(putative membrane protein) SL1344_1447(putative membrane protein) Cluster2557 1 0 1 1 1 1 1 ROD_12381(putative sugar aldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1037(L-fuculose phosphate aldolase,putative aldolase,Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases,L-fuculose phosphate aldolase,Class II Aldolase and Adducin N-terminal domain) b2738(predicted class II aldolase) BN373_21631(aldolase, class II, AraD/FucA family) t2817(possible sugar aldolase) SL1344_2895(possible sugar aldolase) Cluster2558 0 1 1 1 1 1 1 ENC_08560(AraC-type DNA-binding domain-containing proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3668(Right origin-binding protein,right oriC-binding transcriptional activator,DNA gyrase inhibitor,YSIRK-targeted surface antigen transcriptional regulator,Helix-turn-helix domain) pseudob0300(unknown) BN373_21581(putative AraC-type regulatory protein) t1575(putative transcriptional regulator) pseudoSL1344_1601(putative transcriptional regulator (pseudogene)) Cluster2559 1 1 0 1 1 1 1 ROD_14921(conserved hypothetical protein) ENC_31070(competence/damage-inducible protein CinA C-terminal domain) b1537(conserved protein) BN373_21551(competence/damage-inducible protein CinA C-terminal domain protein) t1435(conserved hypothetical protein) SL1344_1444(conserved hypothetical protein) Cluster2560 0 1 1 1 1 1 1 ENC_12080(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2302(hypothetical protein,hypothetical protein,Uncharacterised BCR, YnfA/UPF0060 family) b1582(inner membrane protein, UPF0060 family) BN373_21421(conserved hypothetical protein) t1425(putative membrane protein) SL1344_1434(Hypothetical UPF0060 protein ) Cluster2561 1 1 1 1 1 0 1 ROD_14781(putative exported protein) ENC_12130(Protein of unknown function (DUF1161).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2298(hypothetical protein,Protein of unknown function (DUF1161)) b1586(predicted protein) BN373_21381(conserved hypothetical protein) SL1344_1430(putative exported protein) Cluster2562 1 0 1 1 1 1 1 ROD_14711(protein Mlc (making large colonies protein)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2289(Making large colonies protein,N-acetylmannosamine kinase,Predicted phosphosugar isomerases,ROK family protein (putative glucokinase),ROK family) b1594(Global DNA-binding transcriptional repressor; autorepressor; required for anaerobic growth on glucosamine) BN373_21311(transcriptional regulator Mic) t1409(putative regulatory protein) SL1344_1418(putative regulatory protein) Cluster2563 1 0 1 1 1 1 1 ROD_14671(putative protease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2285(V8-like Glu-specific endopeptidase,Trypsin) b1598(predicted peptidase) BN373_21241(putative enzyme) t1404(putative secreted protein) SL1344_1414(putative secreted protein) Cluster2564 1 0 1 1 1 1 1 ROD_14661(multidrug resistance protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2284(Spermidine export protein MdtI,multidrug efflux system protein MdtI,Membrane transporters of cations and cationic drugs,Small Multidrug Resistance protein) b1599(multidrug efflux system transporter) BN373_21221(multidrug resistance protein MdtI) t1403(putative membrane protein) SL1344_1413(putative membrane protein) Cluster2565 1 1 1 1 2 0 0 ROD_23411(malate:quinone oxidoreductase) ENC_39760(malate:quinone-oxidoreductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1498(Malate:quinone oxidoreductase,malate:quinone oxidoreductase,malate dehydrogenase (acceptor),Malate:quinone oxidoreductase (Mqo)) b2210(malate dehydrogenase, FAD/NAD(P)-binding domain) BN373_21101(malate dehydrogenase (acceptor)),BN373_32341(putative malate:quinone-oxidoreductase) Cluster2566 1 0 1 1 1 1 1 ROD_34871(two-component response regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4343(Transcriptional regulatory protein dcuR,DNA-binding transcriptional activator DcuR,Response regulator of citrate/malate metabolism,nitrogen regulation protein NR(I),Response regulator receiver domain) b4124(DNA-binding response regulator in two-component regulatory system with DcuS) BN373_21061(transcriptional regulatory protein DcuR) t4210(two-component response regulator) SL1344_4240(two-component response regulator) Cluster2567 1 0 1 1 1 1 1 ROD_14551(two-component sensor kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2274(Sensor protein RstB,sensor protein RstB,Signal transduction histidine kinase regulating C4-dicarboxylate transport system,heavy metal sensor kinase,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b1609(sensory histidine kinase in two-component regulatory system with RstA) BN373_20751(sensor protein RstB) t1339(two component sensor kinase) SL1344_1402(two component sensor kinase) Cluster2568 1 0 1 1 1 1 1 ROD_16271(ATP-dependent helicase HrpA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2403(ATP-dependent RNA helicase HrpA,ATP-dependent helicase HrpA,Domain of unknown function (DUF3418)) b1413(predicted ATP-dependent helicase) BN373_20391(ATP-dependent helicase HrpA) t1544(ATP-dependent helicase HrpA) SL1344_1571(ATP-dependent helicase HrpA) Cluster2569 0 1 1 1 1 1 1 ENC_11810(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2410(hypothetical protein) b1382(lipoprotein) BN373_20061(putative lipoprotein) t1548(putative lipoprotein) SL1344_1575(putative lipoprotein) Cluster2570 1 1 1 1 1 0 1 ROD_16371(putative exported protein) ENC_11820(Dicarboxylate transport.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2411(hypothetical protein,Dicarboxylate transport) b1381(predicted protein) BN373_20051(conserved hypothetical protein) SL1344_1576(putative exported protein) Cluster2571 1 0 1 1 1 1 1 ROD_16401(D-lactate dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2412(D-lactate dehydrogenase,D-3-phosphoglycerate dehydrogenase,Phosphoserine aminotransferase,phosphoglycerate dehydrogenase,D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain) b1380(fermentative D-lactate dehydrogenase, NAD-dependent) BN373_20031(D-lactate dehydrogenase) t1550(D-lactate dehydrogenase) SL1344_1577(D-lactate dehydrogenase) Cluster2572 1 0 1 1 1 1 1 ROD_16471(universal stress protein F) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2418(Universal stress protein F,universal stress protein F,Universal stress protein family) b1376(stress-induced protein, ATP-binding protein) BN373_19971(universal stress protein F) t1555(conserved hypothetical protein) SL1344_1582(conserved hypothetical protein) Cluster2573 1 0 1 1 1 1 1 ROD_16611(zinc transport protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2424(Zinc transport protein ZntB,zinc transporter,magnesium and cobalt transport protein CorA,CorA-like Mg2+ transporter protein) b1342(predicted Zn(II) transporter) BN373_19941(zinc transport protein ZntB) t1560(putative membrane transport protein) SL1344_1587(putative membrane transport protein) Cluster2574 1 0 1 1 1 1 1 ROD_16751(periplasmic murein tripeptide binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2436(Periplasmic murein peptide-binding protein precursor,oligopeptide ABC transporter substrate-binding protein OppA,ABC-type oligopeptide transport system, periplasmic component,nickel ABC transporter, nickel/metallophore periplasmic binding protein,Bacterial extracellular solute-binding proteins, family 5 Middle) b1329(murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit) BN373_19371(periplasmic murein peptide-binding protein) t1583(periplasmic murein peptide-binding protein MppA) SL1344_1609(periplasmic murein peptide-binding protein MppA) Cluster2575 1 0 1 1 1 1 1 ROD_07171(putative ammonia monooxygenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3290(Putative ammonia monooxygenase,membrane protein AbrB duplication,Putative ammonia monooxygenase) b0715(regulator of aidB expression; inner membrane protein) BN373_19331(protein AbrB) t2147(putative membrane protein) SL1344_0711(putative membrane protein) Cluster2576 1 0 1 1 1 1 1 ROD_16811(putative ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2445(hypothetical protein,Predicted ATPase,YcjX-like family, DUF463) b1321(conserved protein with nucleoside triphosphate hydrolase domain) BN373_19281(conserved hypothetical protein) t1590(putative ATP-binding protein) SL1344_1615(putative ATP-binding protein) Cluster2577 1 0 1 1 1 1 1 ROD_17061(peptide ABC transporter, substrate-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2465(Dipeptide-binding protein,antimicrobial peptide ABC transporter periplasmic binding protein SapA,ABC-type oligopeptide transport system, periplasmic component,nickel ABC transporter, nickel/metallophore periplasmic binding protein,Bacterial extracellular solute-binding proteins, family 5 Middle) b1294(antimicrobial peptide transport ABC transporter periplasmic binding protein) BN373_19171(peptide ABC transporter, periplasmic peptide-binding protein) t1597(peptide transport periplasmic protein SapA precursor) SL1344_1622(peptide transport periplasmic protein SapA precursor) Cluster2578 1 0 1 1 1 1 1 ROD_17071(peptide ABC transporter, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2466(Peptide transport system permease protein sapB,antimicrobial peptide ABC transporter permease SapB,nickel ABC transporter, permease subunit NikB,Binding-protein-dependent transport system inner membrane component) b1293(antimicrobial peptide transport ABC transporter permease) BN373_19161(peptide ABC transporter, permease protein SapB) t1598(peptide transport system permease protein SapB) SL1344_1623(peptide transport system permease protein SapB) Cluster2579 1 0 1 1 1 1 1 ROD_17131(exoribonuclease II) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2477(Exoribonuclease 2,exoribonuclease II,Exoribonuclease II,exoribonuclease II,RNB domain) b1286(ribonuclease II) BN373_19081(exoribonuclease II) t1615(exoribonuclease II) SL1344_1633(Exoribonuclease II) Cluster2580 1 0 1 1 1 1 1 ROD_17201(tetratricopeptide repeat protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2484(tetratricopeptide repeat protein,Uncharacterized enzyme of heme biosynthesis,putative PEP-CTERM system TPR-repeat lipoprotein,Tetratricopeptide repeat) b1280(TPR-repeats-containing protein) BN373_19021(tetratricopeptide repeat protein) t1621(conserved hypothetical protein) SL1344_1640(conserved hypothetical protein) Cluster2581 1 0 1 1 1 1 1 ROD_17211(putative outer membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2485(Inner membrane protein yciS,Predicted membrane protein,Protein of unknown function (DUF1049)) b1279(inner membrane DUF1049 protein YciS) BN373_19011(conserved hypothetical protein) t1622(conserved hypothetical protein) SL1344_1641(conserved hypothetical protein) Cluster2582 1 0 1 1 1 1 1 ROD_17311(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2494(hypothetical protein,hypothetical protein,Protein of unknown function (DUF2498)) b1273(DUF2498 protein YciN) BN373_18931(conserved hypothetical protein) t1628(conserved hypothetical protein) SL1344_1647(conserved hypothetical protein) Cluster2583 1 0 1 1 1 1 1 ROD_17321(probable protease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2495(Probable protease sohB,putative inner membrane peptidase,signal peptide peptidase SppA, 36K type,Peptidase family S49 N-terminal) b1272(predicted inner membrane peptidase; multicopy suppressor of htrA(degP)) BN373_18921(peptidase, S49 (protease IV) family) t1629(putative protease) SL1344_1648(putative protease) Cluster2584 1 0 1 1 1 1 1 ROD_17331(putative short chain dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2496(Uncharacterized oxidoreductase yciK,putative oxoacyl-(acyl carrier protein) reductase,Uncharacterized conserved protein,3-oxoacyl-[acyl-carrier-protein] reductase,short chain dehydrogenase) b1271(predicted oxoacyl-(acyl carrier protein) reductase, EmrKY-TolC system) BN373_18901(oxidoreductase, short chain dehydrogenase/reductase family) t1630(hypothetical oxidoreductase) SL1344_1649(hypothetical oxidoreductase) Cluster2585 1 0 1 1 1 1 1 ROD_13171(osmotically inducible lipoprotein E) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2141(DNA-binding transcriptional activator OsmE,SmpA / OmlA family) b1739(DNA-binding transcriptional activator) BN373_18521(osmotically-inducible lipoprotein E) t1190(osmotically inducible lipoprotein E precursor) SL1344_1246(osmotically inducible lipoprotein E precursor) Cluster2586 1 0 1 1 1 1 1 ROD_13161(NH3-dependent NAD(+) synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2140(NH(3)-dependent NAD(+) synthetase,NAD synthetase,NAD synthase,NAD+ synthetase,NAD synthase) b1740(NAD synthetase, NH3/glutamine-dependent) BN373_18511(NAD+ synthetase) t1189(NH3-dependent NAD synthetase) SL1344_1245(NH3-dependent NAD synthetase) Cluster2587 1 0 1 1 1 1 1 ROD_13121(N-succinylarginine dihydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2135(N-succinylarginine dihydrolase,succinylarginine dihydrolase,Succinylarginine dihydrolase,succinylarginine dihydrolase,Succinylarginine dihydrolase) b1745(succinylarginine dihydrolase) BN373_18471(succinylarginine dihydrolase) t1185(succinylarginine dihydrolase) SL1344_1241(succinylarginine dihydrolase) Cluster2588 1 1 1 1 1 0 1 ROD_13101(arginine N-succinyltransferase) ENC_14450(arginine succinyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2133(Arginine N-succinyltransferase subunit beta,arginine succinyltransferase,Succinylarginine dihydrolase,arginine N-succinyltransferase,Arginine N-succinyltransferase beta subunit) b1747(arginine succinyltransferase) BN373_18451(arginine N-succinyltransferase) SL1344_1239(arginine N-succinyltransferase) Cluster2589 1 0 1 1 1 1 1 ROD_12951(DNA topoisomerase III) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2118(DNA topoisomerase 3,DNA topoisomerase III,Topoisomerase IA,DNA topoisomerase III,DNA topoisomerase) b1763(DNA topoisomerase III) BN373_18311(DNA topoisomerase 3) t1177(DNA topoisomerase III) SL1344_1233(DNA topoisomerase III) Cluster2590 1 1 1 1 1 0 1 ROD_12721(putative aldose 1-epimerase) ENC_14770(Uncharacterized enzymes related to aldose 1-epimerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2100(Putative glucose-6-phosphate 1-epimerase,Aldose 1-epimerase) b1780(conserved protein) BN373_18181(aldose 1-epimerase family protein) SL1344_1224(conserved hypothetical protein) Cluster2591 1 0 1 1 1 1 1 ROD_12711(putative aldo/keto reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2099(Glyoxal reductase,2,5-diketo-D-gluconate reductase B,Predicted oxidoreductase,voltage-dependent potassium channel beta subunit,Aldo/keto reductase family) b1781(aldo-keto reductase, methylglyoxal to acetol, NADPH-dependent) BN373_18171(oxidoreductase, aldo/keto reductase family) t1167(putative oxidoreductase) SL1344_1223(putative oxidoreductase) Cluster2592 1 0 1 1 1 1 1 ROD_12701(MltA-interacting protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2098(MltA-interacting protein precursor,MltA-interacting protein MipA) b1782(scaffolding protein for murein synthesizing machinery) BN373_18161(MltA-interacting protein MipA) t1165(putative outer membrane protein) SL1344_1221(putative outer membrane protein) Cluster2593 0 1 1 1 1 1 1 ENC_14860(transcriptional regulator, AraC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2091(HTH-type transcriptional repressor of iron proteins A,DNA-binding transcriptional regulator AraC,Adenosine deaminase,YSIRK-targeted surface antigen transcriptional regulator,Helix-turn-helix domain) b1790(predicted DNA-binding transcriptional regulator) BN373_18001(transcriptional regulator, AraC family) t1159(putative transcriptional regulator) SL1344_1215(putative transcriptional regulator) Cluster2594 1 0 1 1 1 1 1 ROD_12531(putative transport protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2083(Leucine efflux protein,leucine export protein LeuE,homoserine/Threonine efflux protein,LysE type translocator) b1798(neutral amino-acid efflux system) BN373_17901(leucine export protein LeuE) t1148(putative membrane transport protein) SL1344_1205(putative membrane transport protein) Cluster2595 1 0 1 1 1 1 1 ROD_27921(palmitoleoyl acyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1338(Lipid A biosynthesis lauroyl acyltransferase,lipid A biosynthesis palmitoleoyl acyltransferase,Lauroyl/myristoyl acyltransferase,lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase,Bacterial lipid A biosynthesis acyltransferase) b2378(palmitoleoyl-acyl carrier protein (ACP)-dependent acyltransferase) BN373_17891(lipid A biosynthesis lauroyl acyltransferase family protein) t0457(putative acyltransferase) SL1344_2369(putative acyltransferase) Cluster2596 1 1 0 1 1 1 1 ROD_17471(conserved hypothetical protein) ENC_31010(Uncharacterized protein conserved in bacteria) b1257(predicted rubrerythrin/ferritin-like metal-binding protein) BN373_17761(conserved hypothetical protein) t1642(conserved hypothetical protein) SL1344_1661(conserved hypothetical protein) Cluster2597 1 1 0 1 1 1 1 ROD_17461(conserved hypothetical protein) ENC_31000(Uncharacterized protein conserved in bacteria) b1258(predicted rubrerythrin/ferritin-like metal-binding protein) BN373_17751(conserved hypothetical protein) t1641(conserved hypothetical protein) SL1344_1660(conserved hypothetical protein) Cluster2598 1 1 0 1 1 1 1 ROD_06231(putative oxidoreductase) ENC_21080(Threonine dehydrogenase and related Zn-dependent dehydrogenases) b0608(predicted oxidoreductase, Zn-dependent and NAD(P)-binding) BN373_17731(oxidoreductase, zinc-binding dehydrogenase family) t2252(hypothetical zinc-dependant alcohol dehydrogenase) SL1344_0603(hypothetical zinc-dependant alcohol dehydrogenase) Cluster2599 1 0 1 1 1 1 1 ROD_12251(ribosomal large subunit pseudouridine synthase E (rRNA pseudouridylate synthase E)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2781(Ribosomal large subunit pseudouridine synthase E,23S rRNA pseudouridine synthase E,pseudouridine synthase,RNA pseudouridylate synthase) b1135(23S rRNA U2457 pseudouridine synthase) BN373_17601(ribosomal large subunit pseudouridine synthase E) t1683(putative ribosomal large subunit pseudouridine synthase B) SL1344_1175(putative ribosomal large subunit pseudouridine synthase B) Cluster2600 1 0 1 1 1 1 1 ROD_12221(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2784(High frequency lysogenization protein HflD,putative lysogenization regulator,Uncharacterized protein involved in purine metabolism,Protein of unknown function (DUF489)) b1132(predicted lysogenization regulator) BN373_17571(conserved hypothetical protein) t1687(conserved hypothetical protein) SL1344_1171(conserved hypothetical protein) Cluster2601 1 0 1 1 1 1 1 ROD_12141(spermidine/putrescine ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2790(Spermidine/putrescine import ATP-binding protein PotA,putrescine/spermidine ABC transporter ATPase protein,ABC-type spermidine/putrescine transport systems, ATPase components,polyamine ABC transporter, ATP-binding protein,ABC transporter) b1126(polyamine transporter subunit) BN373_17491(spermidine/putrescine ABC transporter, ATP-binding protein) t1694(spermidine/putrescine transport ATP-binding protein PotA) SL1344_1163(spermidine/putrescine transport ATP-binding protein PotA (ABC superfamily)) Cluster2602 2 1 1 1 1 0 0 ROD_34751(allose 6-phosphate isomerase/ribose-5-phosphate isomerase B),ROD_50581(ribose 5-phosphate isomerase) ENC_05240(ribose 5-phosphate isomerase B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4375(Ribose-5-phosphate isomerase B,ribose-5-phosphate isomerase B,ribose 5-phosphate isomerase B,Ribose/Galactose Isomerase) b4090(ribose 5-phosphate isomerase B/allose 6-phosphate isomerase) BN373_17391(ribose 5-phosphate isomerase B) Cluster2603 1 0 1 1 1 1 1 ROD_11801(putative peptidoglycan-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2803(Probable L,D-transpeptidase YcfS precursor,L,D-transpeptidase,L,D-transpeptidase catalytic domain) b1113(L,D-transpeptidase linking Lpp to murein) BN373_17251(LysM domain/ErfK/YbiS/YcfS/YnhG family protein) t1705(putative exported protein) SL1344_1152(putative exported protein) Cluster2604 1 0 1 1 1 1 1 ROD_11761(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2804(Multiple stress resistance protein BhsA precursor,hypothetical protein,Protein of unknown function (DUF1471)) b1112(biofilm, cell surface and signaling protein) BN373_17241(conserved hypothetical protein) t1706(putative secreted protein) SL1344_1151(putative secreted protein) Cluster2605 1 1 2 0 2 0 0 pseudoROD_11741(putative tonB-dependent receptor (fragment)) ENC_41810(TonB-dependent siderophore receptor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.760(Iron-regulated outer membrane proteins,vitamin B12/cobalamin outer membrane transporter,Outer membrane receptor for ferrienterochelin and colicins,TonB-dependent siderophore receptor,TonB dependent receptor),Escherichia_coli_UPEC_ST131_v0.1_5_5104002-5133359.31(Iron-regulated outer membrane proteins,vitamin B12/cobalamin outer membrane transporter,Outer membrane receptor for ferrienterochelin and colicins,TonB-dependent siderophore receptor,TonB-dependent Receptor Plug Domain) BN373_17221(ferric aerobactin receptor),BN373_p00291(IutA) Cluster2606 1 0 1 1 1 1 1 ROD_11681(thiamine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2810(Thiamine kinase,thiamine kinase,thiamine kinase,Phosphotransferase enzyme family) b1106(thiamin kinase) BN373_17171(thiamine kinase) t1712(conserved hypothetical protein) SL1344_1145(conserved hypothetical protein) Cluster2607 1 0 1 1 1 1 1 ROD_11671(putative lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2811(Lipoprotein activator of PBP from the outer membrane B,uncharacterized lipoprotein) b1105(outer membrane lipoprotein) BN373_17161(putative lipoprotein) t1713(putative lipoprotein) SL1344_1144(putative lipoprotein) Cluster2608 1 0 1 1 1 1 1 ROD_11591(putative aminodeoxychorismate lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2819(hypothetical protein,putative aminodeoxychorismate lyase,conserved hypothetical protein, YceG family,YceG-like family) b1097(predicted aminodeoxychorismate lyase) BN373_17091(conserved hypothetical protein) t1721(putative secreted protein) SL1344_1136(putative secreted protein) Cluster2609 1 0 1 1 1 1 1 ROD_11531(3-oxoacyl-[acyl-carrier-protein] synthase III) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2825(3-oxoacyl-[acyl-carrier-protein] synthase 3,3-oxoacyl-(acyl carrier protein) synthase III,3-oxoacyl-[acyl-carrier-protein] synthase III,3-oxoacyl-[acyl-carrier-protein] synthase III,3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal) b1091(3-oxoacyl-[acyl-carrier-protein] synthase III) BN373_17031(3-oxoacyl-[acyl-carrier-protein] synthase 3) t1727(3-oxoacyl-[acyl-carrier-protein] synthase III) SL1344_1130(3-oxoacyl-[acyl-carrier-protein] synthase III) Cluster2610 1 1 0 1 1 1 1 ROD_11491(Maf-like protein) ENC_15530(MAF protein) b1087(Maf-like protein) BN373_16991(septum formation protein Maf) t1731(conserved hypothetical protein) SL1344_1126(conserved hypothetical protein) Cluster2611 1 0 1 1 1 1 1 ROD_11481(ribosomal large subunit pseudouridine synthase C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2830(Ribosomal large subunit pseudouridine synthase C,23S rRNA pseudouridylate synthase C,pseudouridine synthase, RluA family,RNA pseudouridylate synthase) b1086(23S rRNA pseudouridine synthase; specific to U955, U2504, and U2580) BN373_16981(ribosomal large subunit pseudouridine synthase C) t1732(ribosomal large subunit pseudouridine synthase C) SL1344_1123(ribosomal large subunit pseudouridine synthase C (EC 4.2.1.70)) Cluster2612 1 0 1 1 1 1 1 ROD_11461(ribonuclease E) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2832(Ribonuclease E,ribonuclease E,Ribonucleases G and E,ribonuclease, Rne/Rng family,Ribonuclease E/G family) b1084(fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein) BN373_16971(ribonuclease E) t1734(ribonuclease E) SL1344_1122(ribonuclease E) Cluster2613 1 0 1 1 1 1 1 ROD_11321(putative outer membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2847(Probable peptidoglycan biosynthesis protein MurJ,integral membrane protein MviN,MviN-like protein) b1069(probable peptidoglycan lipid II flippase required for murein synthesis) BN373_16941(integral membrane protein MviN) t1750(virulence factor MviN) SL1344_1107(virulence factor MviN) Cluster2614 1 0 1 1 1 1 1 pseudoROD_11301(putative oxidoreductase (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2848(Virulence factor mviM homolog,putative oxidoreductase,Uncharacterized protein conserved in bacteria,Oxidoreductase family, NAD-binding Rossmann fold) b1068(predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain) BN373_16931(oxidoreductase family, NAD-binding) t1751(putative virulence factor MviM) SL1344_1106(putative virulence factor MviM) Cluster2615 1 0 1 1 1 1 1 ROD_10941(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2879(Inner membrane protein ycdZ,Protein of unknown function (DUF1097)) b1036(inner membrane protein, DUF1097 family) BN373_16731(putative membrane protein) t1782(putative membrane protein) SL1344_1075(putative membrane protein) Cluster2616 1 0 1 1 1 1 1 pseudoROD_10751(phosphate starvation-inducible protein PhoH (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2890(Phosphate starvation-inducible protein psiH,hypothetical protein,Predicted ATPase related to phosphate starvation-inducible protein PhoH,PhoH-like protein) b1020(conserved protein with nucleoside triphosphate hydrolase domain) BN373_16631(protein phoH) t1795(PhoH protein) SL1344_1064(PhoH protein (phosphate starvation-inducible protein PsiH)) Cluster2617 1 0 1 1 1 1 1 ROD_10701(sodium/proline symporter (proline permease)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2894(Propionate transporter,proline:sodium symporter PutP,Na+/panthothenate symporter,sodium/proline symporter,Sodium:solute symporter family) b1015(proline:sodium symporter) BN373_16571(sodium/proline symporter) t1796(sodium/proline symporter) SL1344_1063(sodium/proline symporter (proline permease)) Cluster2618 1 0 1 1 1 1 1 ROD_10651(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2904(Stress-induced bacterial acidophilic repeat motif) b4518(conserved protein) BN373_16441(stress-induced protein, KGG, repeat protein) t1800(conserved hypothetical protein) SL1344_1059(conserved hypothetical protein) Cluster2619 1 0 1 1 1 1 1 ROD_10621(glucose-1-phosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2907(Glucose-1-phosphatase precursor,glucose-1-phosphatase/inositol phosphatase,Histidine phosphatase superfamily (branch 2)) b1002(glucose-1-phosphatase/inositol phosphatase) BN373_16401(glucose-1-phosphatase) t1803(glucose-1-phosphatase precursor) SL1344_1056(glucose-1-phosphatase precursor (G1Pase), secreted) Cluster2620 1 0 1 1 1 1 1 ROD_10151(3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2946(3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase,3-hydroxydecanoyl-(acyl carrier protein) dehydratase,beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA,FabA-like domain) b0954(beta-hydroxydecanoyl thioester dehydrase) BN373_15951(beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA) t1853(D-3-hydroxydecanoyl-(acyl carrier-protein)) SL1344_1007(D-3-hydroxydecanoyl-(acyl carrier-protein)) Cluster2621 1 0 1 1 1 1 1 ROD_10142(ribosome modulation factor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2947(Ribosome modulation factor,ribosome modulation factor,Ribosome modulation factor,Ribosome modulation factor) b0953(ribosome modulation factor) BN373_15941(ribosome modulation factor) t1854(ribosome modulation factor) SL1344_1006(ribosome modulation factor (protein E)) Cluster2622 1 0 1 1 1 1 1 ROD_09871(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2974(hypothetical protein) b0919(conserved protein) BN373_15621(conserved hypothetical protein) t1945(conserved hypothetical protein) SL1344_0926(conserved hypothetical protein) Cluster2623 1 1 1 1 1 0 1 ROD_09841(conserved hypothetical protein) ENC_17670(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2977(Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF1006)) b0916(conserved protein) BN373_15591(conserved hypothetical protein) SL1344_0923(conserved hypothetical protein) Cluster2624 1 0 1 1 1 1 1 ROD_09731(probable formate transporter 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3042(Formate channel 1,formate transporter,Formate/nitrite family of transporters,formate transporter FocA,Formate/nitrite transporter) b0904(formate channel) BN373_15481(putative formate transporter FocA) t1960(probable formate transporter) SL1344_0911(probable formate transporter (formate channel)) Cluster2625 1 0 1 1 1 1 1 ROD_09601(anaerobic dimethyl sulfoxide reductase chain C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3047(DMSO reductase anchor subunit,DMSO reductase anchor subunit (DmsC)) b0896(dimethyl sulfoxide reductase, anaerobic, subunit C) BN373_15441(anaerobic dimethyl sulfoxide reductase, C subunit) t1968(anaerobic dimethyl sulfoxide reductase chain C) SL1344_0904(anaerobic dimethyl sulfoxide reductase chain C) Cluster2626 1 0 1 1 1 1 1 ROD_09561(putative ATPase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3105(Replication-associated recombination protein A,recombination factor protein RarA,Holliday junction resolvasome, helicase subunit,DNA polymerase III, subunit gamma and tau,MgsA AAA+ ATPase C terminal) b0892(DNA-dependent ATPase involved in processing recombination intermediates at replication forks) BN373_15401(putative DNA recombination-associated ATPase RarA) t1972(conserevd hypothetical protein) SL1344_0900(conserevd hypothetical protein) Cluster2627 1 0 1 1 1 1 1 ROD_09541(dna translocase ftsk) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3107(DNA translocase FtsK,DNA translocase FtsK,DNA segregation ATPase FtsK/SpoIIIE and related proteins,type VII secretion protein EssC,FtsK/SpoIIIE family) b0890(DNA translocase at septal ring sorting daughter chromsomes) BN373_15381(cell division protein) t1974(cell division protein FtsK) SL1344_0898(cell division protein FtsK) Cluster2628 1 0 1 1 1 1 1 ROD_09501(transport ATP-binding protein CydC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3111(Lipid A export ATP-binding/permease protein MsbA,cysteine/glutathione ABC transporter membrane/ATP-binding component,ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components,thiol reductant ABC exporter, CydC subunit,ABC transporter) b0886(fused glutathione, cysteine exporter subunits of ABC superfamily: membrane component/ATP-binding component) BN373_15341(ABC transporter, CydDC cysteine exporter family, permease/ATP-binding protein CydC) t1978(transport ATP-binding protein CydC) SL1344_0894(transport ATP-binding protein CydC) Cluster2629 1 0 1 1 1 1 1 ROD_08811(pyruvate oxidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3127(Pyruvate dehydrogenase [ubiquinone],pyruvate dehydrogenase,Glyoxylate carboligase,pyruvate oxidase,Thiamine pyrophosphate enzyme, N-terminal TPP binding domain) b0871(pyruvate dehydrogenase (pyruvate oxidase), thiamin-dependent, FAD-binding) BN373_15201(pyruvate dehydrogenase (cytochrome)) t1998(pyruvate dehydrogenase) SL1344_0874(pyruvate dehydrogenase) Cluster2630 1 0 1 1 1 1 1 ROD_08741(arginine ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3134(Arginine transport ATP-binding protein ArtP,arginine transporter ATP-binding subunit,ABC-type arginine transport system, ATPase component,ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA,ABC transporter) b0864(arginine transporter subunit) BN373_15121(arginine ABC transporter, ATP-binding protein ArtP) t2005(arginine transport ATP-binding protein ArtP) SL1344_0867(arginine transport ATP-binding protein ArtP) Cluster2631 1 0 1 1 1 1 1 ROD_08641(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3140(Inner membrane protein ybjO,Protein of unknown function (DUF2593)) b0858(inner membrane protein, DUF2593 family) BN373_15041(putative membrane protein) t2015(putative membrane protein) SL1344_0858(putative membrane protein) Cluster2632 1 0 1 1 1 1 1 ROD_08611(putrescine ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3143(Spermidine/putrescine import ATP-binding protein PotA,putrescine transporter ATP-binding subunit,ABC-type spermidine/putrescine transport systems, ATPase components,polyamine ABC transporter, ATP-binding protein,ABC transporter) b0855(putrescine transporter subunit: ATP-binding component of ABC superfamily) BN373_15011(putrescine ABC transporter, ATP-binding protein) t2018(putrescine transport ATP-binding protein PotG) SL1344_0855(putrescine transport ATP-binding protein PotG) Cluster2633 1 0 1 1 1 1 1 ROD_08541(putative transport protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3151(putative transporter,Predicted permease,aspartate-alanine antiporter,Predicted Permease Membrane Region) b0847(predicted transporter) BN373_14931(putative transporter) t2026(putative membrane protein) SL1344_0846(putative membrane protein) Cluster2634 1 0 1 0 1 2 1 ROD_36641(phage baseplate assembly protein W) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3088(Phage P2 baseplate assembly protein gpV,Gene 25-like lysozyme) BN373_14791(baseplate assembly protein W) t3430(phage baseplate assembly protein),t4308(phage baseplate assembly protein) SL1344_2679(bacteriophage baseplate assembly protein) Cluster2635 1 0 2 0 1 1 1 ROD_36651(phage tail spike protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3087(Phage P2 baseplate assembly protein gpV,phage baseplate assembly protein V,Phage-related baseplate assembly protein),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.19(Phage P2 baseplate assembly protein gpV,phage baseplate assembly protein V,Phage-related baseplate assembly protein) BN373_14781(phage baseplate assembly protein V) t4309(putative phage baseplate assembly protein) SL1344_2680(putative bacteriophage baseplate assembly protein) Cluster2636 1 0 1 0 1 2 1 ROD_36661(phage tail completion protein S) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3086(Mu-like prophage protein gpG,phage virion morphogenesis protein,Phage virion morphogenesis family) BN373_14761(putative phage tail completion protein) t3428(putative phage tail protein),t4310(putative phage tail completion protein) SL1344_2681(putative bacteriophage tail completion protein) Cluster2637 1 0 1 0 1 2 1 ROD_36761(putative capsid scaffolding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3076(Phage capsid scaffolding protein (GPO) serine peptidase) BN373_14661(capsid scaffold-like protein) t3418(putative capsid scaffolding protein),t4320(putative capsid protein) SL1344_2692(putative capsid protein) Cluster2638 1 0 1 0 1 2 1 ROD_36771(putative large terminase subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3075(Uncharacterized conserved protein,Terminase-like family) BN373_14651(terminase-like protein) t3417(terminase, ATPase subunit),t4322(probable terminase subunit) SL1344_2693(probable terminase subunit) Cluster2639 1 0 1 0 1 2 1 ROD_36781(putative capsid portal protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3074(phage portal protein, PBSX family,Phage portal protein) BN373_14641(phage portal protein, pbsx family) t3416(probable capsid portal protein),t4321(probable capsid portal protein) SL1344_2694(probable capsid portal protein) Cluster2640 1 0 1 1 1 1 1 ROD_08461(deoxyribose operon repressor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3159(Deoxyribose operon repressor,DNA-binding transcriptional repressor DeoR,Bacterial regulatory proteins, deoR family) b0840(DNA-binding transcriptional repressor) BN373_14391(deoxyribose operon repressor) t2032(deoxyribose operon repressor) SL1344_0840(deoxyribose operon repressor) Cluster2641 1 0 1 1 1 1 1 ROD_08451(penicillin-binding protein 6 (D-alanyl-D-alanine carboxypeptidase)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3160(D-alanyl-D-alanine carboxypeptidase dacC precursor,D-alanyl-D-alanine carboxypeptidase fraction C,D-alanyl-D-alanine carboxypeptidase) b0839(D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 6a)) BN373_14381(serine-type D-Ala-D-Ala carboxypeptidase) t2033(D-alanyl-D-alanine carboxypeptidase) SL1344_0839(D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 6 precursor)) Cluster2642 1 0 1 1 1 1 1 ROD_08401(soluble aldose sugar dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3162(Soluble aldose sugar dehydrogenase yliI precursor,dehydrogenase, PQQ-dependent, s-GDH family,Glucose / Sorbosone dehydrogenase) b0837(soluble aldose sugar dehydrogenase) BN373_14351(aldose sugar dehydrogenase yliI) t2035(putative oxidoreductase) SL1344_0837(putative dehydrogenase) Cluster2643 1 0 1 1 1 1 1 ROD_08381(radical SAM superfamily protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3164(Ribosomal protein S12 methylthiotransferase RimO,ribosomal protein S12 methylthiotransferase,ribosomal protein S12 methylthiotransferase RimO,Radical SAM superfamily) b0835(ribosomal protein S12 methylthiotransferase; radical SAM superfamily) BN373_14321(MiaB-like tRNA modifying enzyme YliG) t2037(conserved hypothetical protein) SL1344_0828(conserved hypothetical protein) Cluster2644 1 1 0 1 1 1 1 ROD_08241(conserved hypothetical protein) ENC_18920(Protein of unknown function (DUF1479).) b0821(predicted protein) BN373_14211(conserved hypothetical protein) t2048(conserved hypothetical protein) SL1344_0817(conserved hypothetical protein) Cluster2645 1 0 1 1 1 1 1 ROD_08111(glutamine ABC transporter, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3188(Glutamine transport system permease protein glnP,glutamine ABC transporter permease protein,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component) b0810(glutamine transporter subunit) BN373_14031(glutamine ABC transporter, permease protein) t2059(glutamine transport system permease protein GlnP) SL1344_0804(glutamine transport system permease protein GlnP) Cluster2646 1 0 1 1 1 1 1 ROD_08101(glutamine ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3189(Glutamine transport ATP-binding protein GlnQ,glutamine ABC transporter ATP-binding protein,ABC-type histidine transport system, ATPase component,ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA,ABC transporter) b0809(glutamine transporter subunit) BN373_14021(glutamine ABC transporter, ATP-binding protein) t2060(glutamine transport ATP-binding protein GlnQ) SL1344_0803(glutamine transport ATP-binding protein GlnQ) Cluster2647 1 0 1 1 1 1 1 ROD_08091(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3190(Potassium efflux system KefA precursor,putative mechanosensitive channel protein,Mechanosensitive ion channel) b0808(predicted mechanosensitive channel) BN373_14011(transporter, small conductance mechanosensitive ion channel (MscS) family) t2061(putative membrane protein) SL1344_0802(putative membrane protein) Cluster2648 1 1 1 1 1 0 1 ROD_08081(conserved hypothetical protein) ENC_19280(23S rRNA m(6)A-1618 methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3191(Ribosomal RNA large subunit methyltransferase F,23S rRNA mA1618 methyltransferase,Protein of unknown function (DUF890)) b0807(23S rRNA mA1618 methyltransferase, SAM-dependent) BN373_14001(conserved hypothetical protein) SL1344_0801(conserved hypothetical protein) Cluster2649 1 1 1 1 1 0 1 ROD_08041(probable ATP-dependent helicase) ENC_19390(Rad3-related DNA helicases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3199(Probable ATP-dependent helicase dinG homolog,ATP-dependent DNA helicase DinG,putative DnaQ family exonuclease/DinG family helicase,DEAD/DEAH box helicase) b0799(ATP-dependent DNA helicase) BN373_13941(putative ATP-dependent helicase DinG) SL1344_0797(probable ATP-dependent helicase DinG) Cluster2650 1 0 1 1 1 1 1 ROD_08031(putative ATP-dependent RNA helicase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3201(ATP-dependent RNA helicase rhlE,ATP-dependent RNA helicase RhlE,Predicted transporter component,ATP-dependent DNA helicase RecQ,DEAD/DEAH box helicase) b0797(ATP-dependent RNA helicase) BN373_13931(putative ATP-dependent RNA helicase RhlE) t2068(putative ATP-dependent RNA helicase rhlE) SL1344_0796(putative ATP-dependent RNA helicase rhlE) Cluster2651 1 0 1 1 1 1 1 ROD_07921(ABC transporter, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3206(Inner membrane transport permease ybhR,inner membrane transport permease,ABC-type transport system involved in multi-copper enzyme maturation, permease component,daunorubicin resistance ABC transporter membrane protein,ABC-2 family transporter protein) b0792(predicted transporter subunit: membrane component of ABC superfamily) BN373_13831(ABC-2 type transporter, permease protein) t2073(putative inner membrane protein) SL1344_0791(putative inner membrane protein) Cluster2652 1 0 1 1 1 1 1 ROD_07901(putative endonuclease/exonuclease/phosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3208(hypothetical protein,Uncharacterized protein conserved in bacteria,Endonuclease/Exonuclease/phosphatase family) b0790(conserved protein, endo/exonuclease/phosphatase family PFAM PF03372) BN373_13811(endonuclease/exonuclease/phosphatase family protein) t2075(conserved hypothetical protein) SL1344_0789(conserved hypothetical protein) Cluster2653 1 1 1 1 1 0 1 ROD_07871(putative membrane protein) ENC_19510(Integral membrane protein, interacts with FtsH) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3212(Inner membrane protein YbhL,Inhibitor of apoptosis-promoting Bax1) b0786(inner membrane protein, UPF0005 family) BN373_13781(inner membrane protein YbhL) SL1344_0783(putative membrane protein) Cluster2654 1 0 1 1 1 1 1 ROD_07811(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3218(hypothetical protein,LPPG:FO 2-phospho-L-lactate transferase,conserved hypothetical protein,Uncharacterised protein family UPF0052) b0780(predicted transferase with NAD(P)-binding Rossmann-fold domain) BN373_13721(conserved hypothetical protein) t2086(conserved hypothetical protein) SL1344_0777(conserved hypothetical protein) Cluster2655 1 1 0 1 1 1 1 ROD_34821(two-component sensor kinase) ENC_34190(Signal transduction histidine kinase) b4112(sensory histidine kinase in two-component regulatory system with BasR) BN373_13691(sensor protein BasS) t4198(two-component sensor kinase) SL1344_4228(two-component sensor kinase) Cluster2656 1 0 1 1 1 1 1 ROD_07791(dethiobiotin synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3220(ATP-dependent dethiobiotin synthetase BioD 1,dithiobiotin synthetase,dethiobiotin synthase,CobQ/CobB/MinD/ParA nucleotide binding domain) b0778(dethiobiotin synthetase) BN373_13651(dethiobiotin synthase) t2090(dethiobiotin synthetase) SL1344_0774(dethiobiotin synthetase) Cluster2657 1 0 1 1 1 1 1 ROD_07771(8-amino-7-oxononanoate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3222(8-amino-7-oxononanoate synthase,8-amino-7-oxononanoate synthase,7-keto-8-aminopelargonate synthetase and related enzymes,8-amino-7-oxononanoate synthase,Aminotransferase class I and II) b0776(8-amino-7-oxononanoate synthase) BN373_13631(8-amino-7-oxononanoate synthase) t2092(8-amino-7-oxononanoate synthase) SL1344_0772(8-amino-7-oxononanoate synthase) Cluster2658 1 0 1 1 1 1 1 ROD_07621(phosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3232(Uncharacterized phosphatase YwpJ,pyridoxal phosphate (PLP) phosphatase,Predicted hydrolase (HAD superfamily),Cof-like hydrolase,haloacid dehalogenase-like hydrolase) b0766(pyridoxal phosphate (PLP) phosphatase) BN373_13361(phosphatase YbhA) t2103(conserved hypothetical protein) SL1344_0761(conserved hypothetical protein) Cluster2659 1 0 1 1 1 1 1 ROD_07611(molybdenum ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3233(Sulfate/thiosulfate import ATP-binding protein CysA,molybdate transporter ATP-binding protein,ABC-type molybdate transport system, ATPase component,molybdate ABC transporter, ATP-binding protein,ABC transporter) b0765(molybdate transporter subunit) BN373_13351(molybdate ABC transporter, ATP-binding protein) t2104(molybdenum transport ATP-binding protein ModC) SL1344_0760(molybdenum transport ATP-binding protein ModC) Cluster2660 1 0 1 1 1 1 1 ROD_07551(UDP-glucose 4-epimerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3239(UDP-glucose 4-epimerase,UDP-galactose-4-epimerase,Uncharacterized conserved protein,UDP-glucose 4-epimerase,NAD dependent epimerase/dehydratase family) b0759(UDP-galactose-4-epimerase) BN373_13291(UDP-glucose 4-epimerase) t2111(UDP-glucose 4-epimerase) SL1344_0753(UDP-glucose 4-epimerase) Cluster2661 1 0 1 1 1 1 1 ROD_07541(galactose-1-phosphate uridylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3240(Galactose-1-phosphate uridylyltransferase,galactose-1-phosphate uridylyltransferase,galactose-1-phosphate uridylyltransferase,Galactose-1-phosphate uridyl transferase, N-terminal domain) b0758(galactose-1-phosphate uridylyltransferase) BN373_13281(galactose-1-phosphate uridylyltransferase) t2112(galactose-1-phosphate uridylyltransferase) SL1344_0752(galactose-1-phosphate uridylyltransferase) Cluster2662 1 0 1 1 1 1 1 ROD_07521(aldose 1-epimerase (mutarotase)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3242(Aldose 1-epimerase,galactose-1-epimerase,galactose mutarotase,Aldose 1-epimerase) b0756(galactose-1-epimerase (mutarotase)) BN373_13261(galactose mutarotase) t2114(aldose 1-epimerase) SL1344_0750(aldose 1-epimerase (mutarotase)) Cluster2663 1 0 1 1 1 1 1 ROD_07411(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3245(hypothetical protein) b0753(conserved protein) BN373_13231(conserved hypothetical protein) t2119(probable secreted protein) SL1344_0736(putative exported protein) Cluster2664 1 0 1 1 1 1 1 ROD_07341(colicin import protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3258(hypothetical protein,translocation protein TolB,Tol-Pal system beta propeller repeat protein TolB,WD40-like Beta Propeller Repeat) b0740(periplasmic protein) BN373_13171(Tol-Pal system beta propeller repeat protein TolB) t2128(tolB protein precursor) SL1344_0730(tolB protein precursor) Cluster2665 1 0 1 1 1 1 1 ROD_07331(colicin import protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3259(hypothetical protein,cell envelope integrity inner membrane protein TolA,Membrane protein involved in colicin uptake,protein TolA,TolA C-terminal) b0739(membrane anchored protein in TolA-TolQ-TolR complex) BN373_13161(protein TolA) t2129(tolA protein) SL1344_0729(tolA protein) Cluster2666 1 0 1 1 1 1 1 ROD_07251(succinyl-CoA synthetase beta chain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3272(Succinyl-CoA ligase [ADP-forming] subunit beta,succinyl-CoA synthetase subunit beta,Succinyl-CoA synthetase, beta subunit,succinate-CoA ligase, beta subunit,ATP-grasp domain) b0728(succinyl-CoA synthetase, beta subunit) BN373_13071(succinate-CoA ligase, beta subunit) t2138(succinyl-CoA synthetase beta chain) SL1344_0720(succinyl-CoA synthetase beta chain) Cluster2667 1 0 1 1 1 1 1 ROD_07111(putative allophanate hydrolase subunit 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3294(Sporulation inhibitor kipI,Allophanate hydrolase subunit 2,conserved hypothetical protein,Allophanate hydrolase subunit 1) b0711(predicted enzyme subunit) BN373_12931(putative carboxylase) t2164(conserved hypothetical protein) SL1344_0693(conserved hypothetical protein) Cluster2668 1 0 1 1 1 1 1 ROD_07101(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3295(hypothetical protein,metal-binding protein,Uncharacterized protein conserved in bacteria,dinuclear metal center protein, YbgI/SA1388 family,NIF3 (NGG1p interacting factor 3)) b0710(conserved metal-binding protein, NIF3 family) BN373_12921(NIF3 family protein) t2165(conserved hypothetical protein) SL1344_0692(conserved hypothetical protein) Cluster2669 1 0 1 1 1 1 1 ROD_07041(potassium-transporting ATPase A chain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3300(potassium-transporting ATPase subunit A,K+-transporting ATPase, A chain,K+-transporting ATPase, A subunit,Potassium-transporting ATPase A subunit) b0698(potassium translocating ATPase, subunit A) BN373_12881(K+-transporting ATPase, A subunit) t2169(potassium-transporting ATPase A chain) SL1344_0688(potassium-transporting ATPase A chain) Cluster2670 1 0 1 1 1 1 1 ROD_07001(two-component response regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3304(KDP operon transcriptional regulatory protein KdpE,DNA-binding transcriptional activator KdpE,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain) b0694(DNA-binding response regulator in two-component regulatory system with KdpD) BN373_12841(KDP operon transcriptional regulatory protein KdpE) t2172(KDP operon transcriptional regulatory protein) SL1344_0684(KDP operon transcriptional regulatory protein) Cluster2671 1 0 1 1 1 1 1 ROD_06811(N-acetylglucosamine-specific PTS system EIICBA components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3325(EIICBA-Glc,PTS system N-acetyl glucosamine specific transporter subunits IIABC,PTS system, N-acetylglucosamine-specific IIBC component,Phosphotransferase system, EIIC) b0679(fused N-acetyl glucosamine specific PTS enzyme: IIC, IIB, and IIA components) BN373_12731(PTS system, N-acetylglucosamine-specific IIBC component) t2190(N-acetylglucosamine-specific IIABC component of PTS system) SL1344_0667(pts system, N-acetylglucosamine-specific IIABC component) Cluster2672 1 0 1 1 1 1 1 ROD_06801(glucosamine-6-phosphate isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3326(Glucosamine-6-phosphate deaminase,glucosamine-6-phosphate deaminase,glucosamine-6-phosphate deaminase,Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase) b0678(glucosamine-6-phosphate deaminase) BN373_12721(glucosamine-6-phosphate isomerase) t2191(glucosamine-6-phosphate isomerase) SL1344_0666(glucosamine-6-phosphate deaminase) Cluster2673 1 0 1 1 1 1 1 ROD_06791(N-acetylglucosamine-6-phosphate deacetylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3327(N-acetylglucosamine-6-phosphate deacetylase,N-acetylglucosamine-6-phosphate deacetylase,Metal-dependent hydrolase involved in phosphonate metabolism,N-acetylglucosamine-6-phosphate deacetylase,Amidohydrolase family) b0677(N-acetylglucosamine-6-phosphate deacetylase) BN373_12711(N-acetylglucosamine-6-phosphate deacetylase) t2192(N-acetylglucosamine-6-phosphate deacetylase) SL1344_0665(N-acetylglucosamine-6-phosphate deacetylase) Cluster2674 1 0 1 1 1 1 1 ROD_06721(PhoH-like protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3341(PhoH-like protein,hypothetical protein,Predicted ATPase related to phosphate starvation-inducible protein PhoH,PhoH-like protein) b0660(predicted protein with nucleoside triphosphate hydrolase domain) BN373_12651(PhoH family protein) t2204(PhoH-like ATP-binding protein) SL1344_0658(PhoH-like ATP-binding protein) Cluster2675 1 1 0 1 1 1 1 ROD_06681(glutamate/aspartate ABC transporter, substrate-binding protein) ENC_20610(ABC-type amino acid transport/signal transduction systems, periplasmic component/domain) b0655(glutamate, aspartate binding protein, periplasmic; part of GltJKLI ABC transporter) BN373_12611(glutamate/aspartate ABC transporter, periplasmic glutamate/aspartate-binding protein) t2208(ABC transporter periplasmic binding protein) SL1344_0654(ABC transporter periplasmic binding protein (glutamate/aspartate?)) Cluster2676 1 0 1 1 1 1 1 ROD_06611(rare lipoprotein B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3358(Rare lipoprotein B,LPS-assembly lipoprotein RlpB,Lipopolysaccharide-assembly) b0641(LPS assembly OM complex LptDE, lipoprotein component) BN373_12531(rare lipoprotein B family protein) t2220(rare lipoprotein B precursor) SL1344_0635(rare lipoprotein B precursor) Cluster2677 1 0 1 1 1 1 1 ROD_06571(alpha-ribazole phosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3361(Alpha-ribazole phosphatase,alpha-ribazole phosphatase,alpha-ribazole phosphatase,Histidine phosphatase superfamily (branch 1)) b0638(predicted alpha-ribazole-5'-P phosphatase) BN373_12501(alpha-ribazole phosphatase) t2224(alpha-ribazole-5'-phosphate phosphatase) SL1344_0631(alpha-ribazole-5'-phosphate phosphatase) Cluster2678 1 0 1 1 1 1 1 ROD_06551(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3362(hypothetical protein,ribosome-associated protein,iojap-like ribosome-associated protein,Domain of unknown function DUF143) b0637(ribosome-associated protein) BN373_12491(iojap family protein) t2225(conserved hypothetical protein) SL1344_0630(conserved hypothetical protein) Cluster2679 1 0 1 1 1 1 1 ROD_06541(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3363(Ribosomal RNA large subunit methyltransferase H,rRNA large subunit methyltransferase,Uncharacterized conserved protein,rRNA large subunit m3Psi methyltransferase RlmH,Predicted SPOUT methyltransferase) b0636(23S rRNA m(3)Psi1915 pseudouridine methyltransferase; SAM-dependent) BN373_12481(conserved hypothetical protein) t2226(conserved hypothetical protein) SL1344_0629(conserved hypothetical protein) Cluster2680 1 0 1 1 1 1 1 ROD_06471(LysR-family transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3370(HTH-type transcriptional regulator LeuO,putative DNA-binding transcriptional regulator) b0629(predicted DNA-binding transcriptional regulator) BN373_12411(putative DNA-binding transcriptional regulator) t2233(lysR-family transcriptional regulator) SL1344_0622(lysR-family transcriptional regulator) Cluster2681 1 0 1 1 1 1 1 ROD_06161(alkyl hydroperoxide reductase subunit C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3392(Alkyl hydroperoxide reductase subunit C,alkyl hydroperoxide reductase subunit C,peroxiredoxin,AhpC/TSA family) b0605(alkyl hydroperoxide reductase, C22 subunit) BN373_12291(alkyl hydroperoxide reductase subunit C) t2260(alkyl hydroperoxide reductase c22 protein) SL1344_0596(alkyl hydroperoxide reductase c22 protein) Cluster2682 0 1 1 1 1 1 1 ENC_21160(2-keto-4-methylthiobutyrate aminotransferase apoenzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3397(Methionine aminotransferase,methionine aminotransferase,Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase,LL-diaminopimelate aminotransferase,Aminotransferase class I and II) b0600(methionine aminotransferase, PLP-dependent) BN373_12241(aminotransferase, classes I and II) t2265(putative aminotransferase) SL1344_0591(putative aminotransferase) Cluster2683 0 1 1 1 1 1 1 ENC_47480(Sugar (pentulose and hexulose) kinases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.103(L-xylulose/3-keto-L-gulonate kinase,autoinducer-2 (AI-2) kinase,Pentose-5-phosphate-3-epimerase,xylulokinase,FGGY family of carbohydrate kinases, N-terminal domain) b3580(L-xylulose kinase) BN373_12141(carbohydrate kinase, FGGY family) t3845(putative L-xylulose kinase) SL1344_3639(putative L-xylulose kinase) Cluster2684 0 1 1 1 1 1 1 ENC_21290(Glycerol dehydrogenase and related enzymes) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3398(Glycerol dehydrogenase,putative oxidoreductase,Glycerol dehydrogenase and related enzymes,Iron-containing alcohol dehydrogenase) b0599(predicted oxidoreductase) BN373_11991(alcohol dehydrogenase, iron-containing) t2266(putative oxidoreductase) SL1344_0590(putative oxidoreductase) Cluster2685 1 0 1 1 1 1 1 ROD_06011(ferrienterobactin-binding periplasmic protein precursor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3406(Ferrienterobactin-binding periplasmic protein precursor,iron-enterobactin transporter periplasmic binding protein,ABC-type Fe2+-enterobactin transport system, periplasmic component,heme ABC transporter, heme-binding protein isdE,Periplasmic binding protein) b0592(iron-enterobactin transporter subunit) BN373_11881(ferric enterobactin ABC transporter, periplasmic ferrienterobactin-binding protein) t2274(ferrienterobactin-binding periplasmic protein precursor) SL1344_0582(ferrienterobactin-binding periplasmic protein precursor) Cluster2686 0 1 1 1 1 1 1 ENC_21470(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3413(hypothetical protein,Uncharacterized protein conserved in bacteria,MbtH-like protein) b4511(conserved protein) BN373_11821(mbtH-like protein) t2281(conserved hypothetical protein) SL1344_0575(conserved hypothetical protein) Cluster2687 1 0 1 1 1 1 1 ROD_05951(enterochelin esterase (ferric enterobactin esterase)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3414(Ferric enterobactin esterase,enterobactin/ferric enterobactin esterase,Predicted hydrolase of the alpha/beta superfamily,Putative esterase) b0585(enterobactin/ferric enterobactin esterase) BN373_11811(enterobactin esterase Fes) t2282(enterochelin esterase) SL1344_0574(enterochelin esterase) Cluster2688 1 0 1 1 1 1 1 ROD_05921(4'-phosphopantetheinyl transferase (enterobactin synthetase component D)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3416(phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex,4'-phosphopantetheinyl transferase superfamily) b0583(phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex) BN373_11791(enterochelin synthetase component D) t2284(enterobactin synthetase component D) SL1344_0572(enterobactin synthetase component D) Cluster2689 1 2 1 0 1 0 1 ROD_26211(putative phage repressor protein) ENC_17410(Predicted transcriptional regulator),ENC_27520(Predicted transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2770(Uncharacterized HTH-type transcriptional regulator HI_1476,anaerobic benzoate catabolism transcriptional regulator,transcriptional regulator, y4mF family,Peptidase S24-like) BN373_09941(putative phage repressor protein CI) SL1344_1967(predicted bacteriophage protein) Cluster2690 1 0 1 1 1 1 1 ROD_05561(UDP-2,3-diacylglucosamine hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3454(UDP-2,3-diacylglucosamine hydrolase,UDP-2,3-diacylglucosamine hydrolase,Uncharacterized protein conserved in bacteria,UDP-2,3-diacylglucosamine hydrolase,Calcineurin-like phosphoesterase superfamily domain) b0524(UDP-2,3-diacylglucosamine pyrophosphatase) BN373_09691(UDP-2,3-diacylglucosamine hydrolase) t2326(conserved hypothetical protein) SL1344_0528(conserved hypothetical protein) Cluster2691 1 0 1 1 1 1 1 ROD_05541(phosphoribosylaminoimidazole carboxylase ATPase subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3457(N5-carboxyaminoimidazole ribonucleotide synthase,phosphoribosylaminoimidazole carboxylase ATPase subunit,Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase),phosphoribosylaminoimidazole carboxylase, ATPase subunit,ATP-grasp domain) b0522(N5-carboxyaminoimidazole ribonucleotide synthase) BN373_09661(phosphoribosylaminoimidazole carboxylase, ATPase subunit) t2328(phosphoribosylaminoimidazole carboxylase ATPase subunit) SL1344_0526(phosphoribosylaminoimidazole carboxylase ATPase subunit) Cluster2692 1 0 1 1 1 1 1 ROD_05461(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3486(hypothetical protein,ABC-type uncharacterized transport system, permease component,conserved hypothetical protein,Uncharacterised protein family (UPF0014)) b0491(inner membrane protein, UPF0014 family) BN373_09581(putative membrane protein) t2357(putative membrane protein) SL1344_0496(putative membrane protein) Cluster2693 1 0 1 1 1 1 1 ROD_05421(copper efflux regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3491(Copper export regulator,DNA-binding transcriptional regulator CueR,Transcriptional regulator, effector-binding domain/component,Cu(I)-responsive transcriptional regulator,MerR, DNA binding) b0487(DNA-binding transcriptional activator of copper-responsive regulon genes) BN373_09541(Cu(I)-responsive transcriptional regulator) t2361(copper efflux regulator) SL1344_0492(copper efflux regulator) Cluster2694 1 1 0 1 1 1 1 ROD_05401(conserved hypothetical protein) ENC_22450(Uncharacterized protein conserved in bacteria) b0482(GumN family protein) BN373_09521(GumN family protein) t2364(conserved hypothetical protein) SL1344_0489(conserved hypothetical protein) Cluster2695 1 1 1 1 1 0 1 ROD_05381(protein UshA precursor) ENC_22470(5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3501(hypothetical protein,bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor,Predicted RNA-binding protein, contains TRAM domain,NAD nucleotidase,5'-nucleotidase, C-terminal domain) b0480(bifunctional UDP-sugar hydrolase/5'-nucleotidase) BN373_09501(UDP-sugar hydrolase/5'-nucleotidase) SL1344_0487(UDP-sugar hydrolase) Cluster2696 1 0 1 1 1 1 1 ROD_05351(inosine-guanosine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3504(Inosine-guanosine kinase,inosine/guanosine kinase,pfkB family carbohydrate kinase) b0477(inosine/guanosine kinase) BN373_09461(inosine kinase) t2369(inosine-guanosine kinase) SL1344_0484(inosine-guanosine kinase) Cluster2697 1 1 1 1 1 1 0 ROD_05261(putative membrane protein) ENC_22590(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3513(Inner membrane protein ybaN,hypothetical protein,Protein of unknown function (DUF454)) b0468(inner membrane protein, DUF454 family) BN373_09381(putative membrane protein) t2378(putative membrane protein) Cluster2698 1 0 1 1 1 1 1 ROD_05241(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3515(hypothetical protein,Protein of unknown function (DUF2496)) b0466(predicted protein) BN373_09361(conserved hypothetical protein) t2380(conserved hypothetical protein) SL1344_0473(conserved hypothetical protein) Cluster2699 1 0 1 1 1 1 1 ROD_05201(potassium efflux protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3516(Potassium efflux system KefA precursor,hypothetical protein,Mechanosensitive ion channel inner membrane domain 1) b0465(fused conserved protein) BN373_09341(potassium efflux protein) t2382(integral membrane protein AefA) SL1344_0471(integral membrane protein AefA) Cluster2700 1 0 1 1 1 1 1 ROD_05181(acriflavin resistance protein A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3518(Acriflavine resistance protein A precursor,multidrug efflux system transporter AcrA,efflux transporter, RND family, MFP subunit,HlyD family secretion protein) b0463(multidrug efflux system) BN373_09321(acriflavine resistance protein A) t2384(acriflavin resistance protein A precursor) SL1344_0469(acriflavin resistance protein A precursor) Cluster2701 0 1 1 1 1 1 1 ENC_22750(LSU ribosomal protein L36P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3678(50S ribosomal protein L36 2,50S ribosomal protein L36,ribosomal protein L36,Ribosomal protein L36) b4506(rpmJ (L36) paralog) BN373_09241(ribosomal protein L36) t2390(putative 50S ribosomal protein L36) SL1344_0463(putative 50s ribosomal protein L36 (second copy)) Cluster2702 0 1 1 1 1 1 1 ENC_22760(LSU ribosomal protein L31P) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3677(50S ribosomal protein L31 type B,50S ribosomal protein L31 type B,Ribosomal protein L31,ribosomal protein L31,Ribosomal protein L31) b0296(rpmE (L31) paralog) BN373_09231(50S ribosomal protein L31 type B) t2391(putative 50S ribosomal protein L31) SL1344_0462(putative 50s ribosomal protein L31 (second copy)) Cluster2703 1 1 1 1 2 0 0 ROD_04001(lactose operon repressor) ENC_22820(transcriptional regulator, LacI family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3626(Lactose operon repressor,lac repressor,ABC-type sugar transport system, periplasmic component,catabolite control protein A,Periplasmic binding proteins and sugar binding domain of LacI family) b0345(DNA-binding transcriptional repressor) BN373_09221(sugar binding transcriptional regulator, LacI family),BN373_21781(lactose operon repressor) Cluster2704 1 1 1 1 1 0 1 ROD_29031(nickel/cobalt efflux system) ENC_22800(ABC-type uncharacterized transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1607(Nickel/cobalt efflux system rcnA,nickel/cobalt efflux protein RcnA,Uncharacterized conserved protein,High-affinity nickel-transport protein) b2106(membrane protein conferring nickel and cobalt resistance) BN373_09111(nickel/cobalt efflux protein RcnA) SL1344_3002(putative High affinity Nickel transport protein) Cluster2705 1 0 1 1 1 1 1 ROD_05091(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3528(hypothetical protein) b0453(outer membrane lipoprotein) BN373_09051(putative lipoprotein) t2394(conserved hypothetical lipoprotein) SL1344_0459(conserved hypothetical lipoprotein) Cluster2706 1 0 1 1 1 1 1 ROD_05031(putative ABC transporter, ATP-binding/permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3533(Probable multidrug resistance ABC transporter ATP-binding/permease protein YheI,putative multidrug transporter membrane\ATP-binding components,ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain,lipid A export permease/ATP-binding protein MsbA,ABC transporter transmembrane region) b0448(fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components) BN373_09001(multidrug ABC transporter, permease/ATP-binding protein) t2399(putative ABC transporter ATP-binding membrane protein) SL1344_0454(putative ABC transporter ATP-binding membrane protein) Cluster2707 1 0 1 1 1 1 1 ROD_04951(DNA-binding protein HU-beta) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3541(NS1,transcriptional regulator HU subunit beta,integration host factor, beta subunit,Bacterial DNA-binding protein) b0440(HU, DNA-binding transcriptional regulator, beta subunit) BN373_08911(DNA-binding protein HU, beta subunit) t2409(DNA-binding protein HU-beta) SL1344_0445(DNA-binding protein HU-beta) Cluster2708 1 0 1 1 1 1 1 ROD_04861(cytochrome o ubiquinol oxidase subunit 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3551(Ubiquinol oxidase subunit 1,cytochrome o ubiquinol oxidase subunit I,cytochrome o ubiquinol oxidase, subunit I,Cytochrome C and Quinol oxidase polypeptide I) b0431(cytochrome o ubiquinol oxidase subunit I) BN373_08821(cytochrome o ubiquinol oxidase, subunit I) t2418(cytochrome o ubiquinol oxidase subunit I) SL1344_0436(cytochrome o ubiquinol oxidase subunit I) Cluster2709 1 0 1 1 1 1 1 ROD_04741(2-dehydropantoate 2-reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3557(2-dehydropantoate 2-reductase,2-dehydropantoate 2-reductase,Ketopantoate reductase,2-dehydropantoate 2-reductase,Ketopantoate reductase PanE/ApbA C terminal) b0425(2-dehydropantoate reductase, NADPH-specific) BN373_08671(2-dehydropantoate 2-reductase) t2430(ApbA) SL1344_0428(2-dehydropantoate 2-reductase) Cluster2710 1 0 1 1 1 1 1 ROD_04671(phosphatidylglycerophosphatase A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3564(Phosphatidylglycerophosphatase A,phosphatidylglycerophosphatase A,Phosphatidylglycerophosphatase A) b0418(phosphatidylglycerophosphatase A) BN373_08591(phosphatidylglycerophosphatase A) t2443(phosphatidylglycerophosphatase A) SL1344_0414(phosphatidylglycerophosphatase A) Cluster2711 1 0 1 1 1 1 1 ROD_04651(N utilization substance protein B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3566(N utilization substance protein B,transcription antitermination protein NusB,transcription antitermination factor NusB,NusB family) b0416(transcription antitermination protein) BN373_08571(transcription antitermination factor NusB) t2445(N utilization substance protein B) SL1344_0412(N utilization substance protein B) Cluster2712 1 0 1 1 1 1 1 ROD_04621(transcriptional repressor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3569(Transcriptional repressor NrdR,transcriptional regulator NrdR,transcriptional regulator NrdR,ATP cone domain) b0413(conserved protein) BN373_08541(transcriptional regulator, NrdR family) t2448(hypothetical protein) SL1344_0409(conserved hypothetical protein) Cluster2713 1 0 1 1 1 1 1 ROD_04571(protein-export protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3573(hypothetical protein,preprotein translocase subunit SecF,protein-export membrane protein SecF,Protein export membrane protein) b0409(SecYEG protein translocase auxillary subunit) BN373_08491(protein-export membrane protein SecF) t2455(export membrane protein SecF) SL1344_0403(protein-export membrane protein SecF) Cluster2714 1 0 1 1 1 1 1 ROD_04461(proline-specific permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3580(Proline-specific permease ProY,putative proline-specific permease,Amino acid transporters,GABA permease,Amino acid permease) b0402(proline-specific permease) BN373_08311(proline-specific permease ProY) t2463(proline-specific permease ProY) SL1344_0395(proline-specific permease ProY) Cluster2715 1 0 1 1 1 1 1 ROD_04441(phosphate regulon two-component system, sensor kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3582(Phosphate regulon sensor protein phoR,phosphate regulon sensor protein,Predicted periplasmic ligand-binding sensor domain,phosphate regulon sensor kinase PhoR,Domain of unknown function (DUF3329)) b0400(sensory histidine kinase in two-component regulatory system with PhoB) BN373_08291(phosphate regulon sensor kinase PhoR) t2466(phosphate regulon sensor protein PhoR) SL1344_0393(phosphate regulon sensor protein PhoR) Cluster2716 1 0 1 1 1 1 1 ROD_04381(probable manno(fructo)kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3587(Fructokinase,fructokinase,Predicted phosphosugar isomerases,ROK family protein (putative glucokinase),ROK family) b0394(manno(fructo)kinase) BN373_08251(manno(fructo)kinase) t2471(hypothetical ROK-family protein) SL1344_0388(hypothetical ROK-family protein) Cluster2717 1 0 1 1 1 1 1 ROD_04371(recombination associated protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3588(Recombination-associated protein rdgC,recombination associated protein,Putative exonuclease, RdgC) b0393(nucleoid-associated ssDNA and dsDNA binding protein; competitive inhibitor of RecA function) BN373_08241(putative recombination-associated exonuclease RdgC) t2472(recombination associated protein RdgC) SL1344_0387(recombination associated protein RdgC) Cluster2718 1 1 1 1 1 0 1 ROD_04351(putative chorismate biosynthesis protein) ENC_23710(AroM protein.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3591(hypothetical protein,AroM protein) b0390(conserved protein, AroM family; regulated by aroR) BN373_08221(AroM protein) SL1344_0385(AroM protein) Cluster2719 1 0 1 1 1 1 1 ROD_04321(shikimate kinase II) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3593(Shikimate kinase 2,shikimate kinase II,5-enolpyruvylshikimate-3-phosphate synthase,Shikimate kinase) b0388(shikimate kinase II) BN373_08201(shikimate kinase) t2476(shikimate kinase II) SL1344_0383(shikimate kinase II) Cluster2720 1 0 1 1 1 1 1 ROD_04231(D-alanine:D-alanine ligase A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3600(D-alanine--D-alanine ligase A,D-alanyl-alanine synthetase A,Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase),D-alanine--D-alanine ligase,D-ala D-ala ligase C-terminus) b0381(D-alanine-D-alanine ligase A) BN373_08111(D-alanine--D-alanine ligase A) t2484(D-alanine:D-alanine ligase A) SL1344_0375(D-alanine:D-alanine ligase A) Cluster2721 1 0 1 1 1 1 1 ROD_04171(penicillin-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3606(D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH precursor,beta-lactam binding protein AmpH,Uncharacterized protein conserved in bacteria,Beta-lactamase) b0376(penicillin-binding protein) BN373_08051(penicillin-binding protein AmpH) t2489(penicillin-binding protein AmpH) SL1344_0370(penicillin-binding protein AmpH) Cluster2722 1 0 1 1 1 1 1 ROD_03321(aminoacyl-histidine dipeptidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3704(Cytosol non-specific dipeptidase,aminoacyl-histidine dipeptidase,Xaa-His dipeptidase,Peptidase family M20/M25/M40) b0237(aminoacyl-histidine dipeptidase (peptidase D)) BN373_07331(aminoacyl-histidine dipeptidase) t2534(aminoacyl-histidine dipeptidase precursor) SL1344_0312(aminoacyl-histidine dipeptidase precursor) Cluster2723 1 0 1 1 1 1 1 ROD_02161(membrane-bound lytic murein transglycosylase D precursor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3768(Membrane-bound lytic murein transglycosylase D precursor,membrane-bound lytic murein transglycosylase D,spore coat assembly protein SafA,LysM domain) b0211(predicted membrane-bound lytic murein transglycosylase D) BN373_07111(membrane-bound lytic murein transglycosylase D) t2605(membrane-bound lytic murein transglycosylase d precursor) SL1344_0255(membrane-bound lytic murein transglycosylase d precursor) Cluster2724 1 0 1 1 1 1 1 ROD_02101(D,D-heptose 1,7-bisphosphate phosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3778(D,D-heptose 1,7-bisphosphate phosphatase,D,D-heptose 1,7-bisphosphate phosphatase,D,D-heptose 1,7-bisphosphate phosphatase,haloacid dehalogenase-like hydrolase) b0200(D,D-heptose 1,7-bisphosphate phosphatase) BN373_07051(D,D-heptose 1,7-bisphosphate phosphatase) t0251(conserved hypothetical protein) SL1344_0249(conserved hypothetical protein) Cluster2725 1 0 1 1 1 1 1 ROD_02001(copper homeostasis protein (lipoprotein nlpE)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3786(Copper homeostasis protein CutF,lipoprotein involved with copper homeostasis and adhesion,Uncharacterized lipoprotein NlpE involved in copper resistance) b0192(lipoprotein involved with copper homeostasis and adhesion) BN373_06971(copper homeostasis protein CutF) t0243(copper homeostasis protein CutF precursor) SL1344_0242(copper homeostasis protein CutF precursor (lipoprotein nlpE)) Cluster2726 1 0 1 1 1 1 1 ROD_01982(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3789(hypothetical protein,hypothetical protein,Uncharacterised protein family (UPF0253)) b4406(conserved protein) BN373_06946(hypothetical protein,hypothetical protein,Uncharacterised protein family (UPF0253)) t0240(conserved hypothetical protein) SL1344_0239(Hypothetical UPF0253 protein) Cluster2727 1 0 1 1 1 1 1 ROD_01841(acyl-[acyl-carrier-protein]--UDP-N-acetylglucos amine O-acyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3798(Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosam ine O-acyltransferase,UDP-N-acetylglucosamine acyltransferase,Acetyltransferase (isoleucine patch superfamily),acyl-[acyl-carrier-protein]-UDP-N-acetylglucos amine O-acyltransferase,Bacterial transferase hexapeptide (six repeats)) b0181(UDP-N-acetylglucosamine acetyltransferase) BN373_06861(acyl-[acyl-carrier-protein]-UDP-N-acetylglucosa mine O-acyltransferase) t0229(acyl-[acyl-carrier-protein]:UDP-N-acetylglucosamine O-acyltransferase) SL1344_0229(Acyl-[acyl-carrier-protein]--UDP-N-acetylglucos amine O-acyltransferase) Cluster2728 1 0 1 1 1 1 1 ROD_01831((3r)-hydroxymyristol acyl carrier protein dehydratase (ec 4.2.1.-)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3799((3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase,(3R)-hydroxymyristoyl-ACP dehydratase,beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ,FabA-like domain) b0180((3R)-hydroxymyristol acyl carrier protein dehydratase) BN373_06851(beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ) t0228((3R)-hydroxymyristol acyl carrier protein dehydrase) SL1344_0228((3R)-hydroxymyristol acyl carrier protein dehydrase) Cluster2729 1 0 1 1 1 1 1 ROD_01781(phosphatidate cytidylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3804(Phosphatidate cytidylyltransferase,CDP-diglyceride synthase,Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase,Cytidylyltransferase family) b0175(CDP-diglyceride synthase) BN373_06801(phosphatidate cytidylyltransferase) t0223(phosphatidate cytidylyltransferase) SL1344_0223(phosphatidate cytidylyltransferase) Cluster2730 1 0 1 1 1 1 1 ROD_01751(ribosome recycling factor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3808(Ribosome-releasing factor,ribosome recycling factor,Translation elongation factor Ts,ribosome recycling factor,Ribosome recycling factor) b0172(ribosome recycling factor) BN373_06771(ribosome recycling factor) t0220(ribosome recycling factor) SL1344_0220(Ribosome recycling factor) Cluster2731 1 0 1 1 1 1 1 ROD_01661(carbohydrate diacid regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3817(Sugar diacid regulator,carbohydrate diacid transcriptional activator CdaR,Sugar diacid utilization regulator,Putative sugar diacid recognition) b0162(DNA-binding transcriptional regulator for gar and gud operons; carbohydrate diacid regulator) BN373_06681(carbohydrate diacid regulator) t0211(conserved hypothetical protein) SL1344_0211(conserved hypothetical protein) Cluster2732 1 0 1 1 1 1 1 ROD_01621(vitamin B12-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3821(Vitamin B12-binding protein precursor,vitamin B12-transporter protein BtuF,ABC-type hemin transport system, periplasmic component,putative ABC transporter PGF-CTERM-modified substrate-binding protein,Periplasmic binding protein) b0158(vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily) BN373_06641(vitamin B12-binding protein) t0207(cobalamin periplasmic binding protein) SL1344_0207(Vitamin B12 transport protein btuF precursor) Cluster2733 1 1 1 1 1 0 1 ROD_01541(ferrichrome-iron TonB-dependent receptor) ENC_46710(TonB-dependent siderophore receptor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3829(Ferric hydroxamate uptake,ferrichrome outer membrane transporter,Outer membrane receptor for monomeric catechols,TonB-dependent siderophore receptor,TonB dependent receptor) b0150(ferrichrome outer membrane transporter) BN373_06561(ferrichrome-iron receptor) SL1344_0192(ferrichrome-iron receptor) Cluster2734 1 1 2 1 1 0 0 ROD_44971(putative T2SS protein D) ENC_18330(general secretion pathway protein D) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.371(Pullulanase secretion envelope pulD,putative outer membrane porin HofQ,Type II secretory pathway, component HofQ,type II secretion system protein D,Bacterial type II and III secretion system protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.744(Pullulanase secretion envelope pulD,putative outer membrane porin HofQ,Type II secretory pathway, component HofQ,type II secretion system protein D,Bacterial type II and III secretion system protein) b3325(general secretory pathway component, cryptic) BN373_06501(pullulanase secretion envelope protein PulD) Cluster2735 1 1 2 1 1 0 0 ROD_44941(putative T2SS protein G) ENC_18300(general secretion pathway protein G) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.368(Pullulanase secretion protein pulG,putative major pilin subunit,Tfp pilus assembly protein PilE,type II secretion system protein G,Bacterial type II secretion system protein G),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.747(Cholera toxin secretion protein epsG,putative major pilin subunit,Tfp pilus assembly protein PilE,type II secretion system protein G,Bacterial type II secretion system protein G) b3328(pseudopilin, cryptic, general secretion pathway) BN373_06471(pullulanase secretion protein PulG) Cluster2736 1 1 2 1 1 0 0 ROD_44901(putative T2SS protein K) ENC_18260(Type II secretory pathway, component PulK) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.364(Type II secretory pathway, component PulK,General secretion pathway protein K),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.751(Type II secretory pathway, component PulK,General secretion pathway protein K) b3332(general secretory pathway component, cryptic) BN373_06431(pullulanase secretion protein PulK) Cluster2737 1 0 1 1 1 1 1 ROD_01521(ATP-dependent helicase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3835(ATP-dependent RNA helicase HrpB,Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein),ATP-dependent helicase HrpB,ATP-dependent helicase C-terminal) b0148(predicted ATP-dependent helicase) BN373_06381(ATP-dependent helicase HrpB) t0197(ATP-dependent helicase HrpB) SL1344_0190(ATP-dependent helicase HrpB) Cluster2738 1 0 1 1 1 1 1 ROD_01481(glutamyl-Q tRNA(Asp) synthetase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3839(Glutamyl-Q tRNA(Asp) synthetase,glutamyl-Q tRNA(Asp) synthetase,Glutamyl- and glutaminyl-tRNA synthetases,glutamyl-queuosine tRNA(Asp) synthetase,tRNA synthetases class I (E and Q), catalytic domain) b0144(glutamyl-Q tRNA(Asp) synthetase) BN373_06341(glutamyl-Q tRNA(Asp) synthetase) t0193(glutamyl-tRNA synthetase-related protein) SL1344_0186(glutamyl-tRNA synthetase-related protein) Cluster2739 1 0 1 1 1 1 1 ROD_01471(poly(A) polymerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3840(Poly(A) polymerase precursor,poly(A) polymerase I,poly(A) polymerase,Polymerase A arginine-rich C-terminus) b0143(poly(A) polymerase I) BN373_06331(poly(A) polymerase) t0192(poly(A) polymerase) SL1344_0185(poly(A) polymerase) Cluster2740 1 0 1 1 1 1 1 ROD_01441(pantoate--beta-alanine ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3850(Pantothenate synthetase,pantoate--beta-alanine ligase,Panthothenate synthetase,pantoate--beta-alanine ligase,Pantoate-beta-alanine ligase) b0133(pantothenate synthetase) BN373_06301(pantoate--beta-alanine ligase) t0182(pantoate:beta-alanine ligase) SL1344_0182(Pantoate--beta-alanine ligase) Cluster2741 1 0 1 1 1 1 1 ROD_01391(ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3857(Daunorubicin/doxorubicin resistance ATP-binding protein DrrA,nodulation ABC transporter NodI,ABC-type Na+ transport system, ATPase component,daunorubicin resistance ABC transporter, ATP-binding protein,ABC transporter) b0127(predicted transporter subunit: ATP-binding component of ABC superfamily) BN373_06251(ABC transporter, ATP-binding protein) t0178(hypothetical ABC transporter ATP-binding protein) SL1344_0173(hypothetical ABC transporter ATP-binding protein) Cluster2742 1 0 1 1 1 1 1 ROD_01311(S-adenosylmethionine decarboxylase proenzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3864(S-adenosylmethionine decarboxylase proenzyme precursor,S-adenosylmethionine decarboxylase,Spermidine synthase,S-adenosylmethionine decarboxylase proenzyme,S-adenosylmethionine decarboxylase) b0120(S-adenosylmethionine decarboxylase) BN373_06161(S-adenosylmethionine decarboxylase proenzyme) t0170(S-adenosylmethionine decarboxylase proenzyme) SL1344_0166(S-adenosylmethionine decarboxylase, proenzyme) Cluster2743 1 0 1 1 1 1 1 ROD_01241(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3867(Protein of unknown function (DUF3300)) b0117(predicted protein) BN373_06131(conserved hypothetical protein) t0163(putative exported protein) pseudoSL1344_0157(putative exported protein) Cluster2744 1 0 1 1 1 1 1 ROD_01091(GMP reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3885(GMP reductase,guanosine 5'-monophosphate oxidoreductase,guanosine monophosphate reductase,IMP dehydrogenase / GMP reductase domain) b0104(GMP reductase) BN373_05961(guanosine monophosphate reductase) t0147(GMP reductase) SL1344_0141(GMP reductase) Cluster2745 1 1 0 1 1 1 1 ROD_01041(preprotein translocase SecA subunit) ENC_46100(protein translocase subunit secA) b0098(preprotein translocase subunit, ATPase) BN373_05911(preprotein translocase, SecA subunit) t0140(preprotein translocase SecA subunit) SL1344_0136(preprotein translocase SecA subunit) Cluster2746 1 0 1 1 1 1 1 ROD_00861(fructose repressor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3908(Catabolite repressor/activator,DNA-binding transcriptional regulator FruR,ABC-type sugar transport system, periplasmic component,D-fructose-responsive transcription factor,Bacterial regulatory proteins, lacI family) b0080(DNA-binding transcriptional repressor-activator for carbon metabolism) BN373_05731(fructose repressor) t0122(fructose repressor) SL1344_0118(fructose repressor) Cluster2747 1 0 1 1 1 1 1 ROD_00821(2-isopropylmalate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3913(2-isopropylmalate synthase,2-isopropylmalate synthase,Isopropylmalate/homocitrate/citramalate synthases,2-isopropylmalate synthase,HMGL-like) b0074(2-isopropylmalate synthase) BN373_05681(2-isopropylmalate synthase LeuA) t0117(2-isopropylmalate synthase) SL1344_0113(2-isopropylmalate synthase) Cluster2748 1 0 1 1 1 1 1 ROD_13551(3-dehydroquinate dehydratase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2186(3-dehydroquinate dehydratase,3-dehydroquinate dehydratase,5-enolpyruvylshikimate-3-phosphate synthase,3-dehydroquinate dehydratase, type I,Type I 3-dehydroquinase) b1693(3-dehydroquinate dehydratase) BN373_05611(3-dehydroquinate dehydratase, type I) t1231(3-dehydroquinate dehydratase) SL1344_1292(3-dehydroquinate dehydratase) Cluster2749 1 0 1 1 1 1 1 ROD_00751(thiamine ABC transport system, substrate-binding protein precursor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3920(Thiamine-binding periplasmic protein precursor,thiamine transporter substrate binding subunit,ABC-type thiamine transport system, periplasmic component,thiamin/thiamin pyrophosphate ABC transporter, thiamin/thiamin pyrophospate-binding protein,Bacterial extracellular solute-binding protein) b0068(thiamin transporter subunit) BN373_05551(thiamin/thiamin pyrophosphate ABC transporter, periplasmic thiamin/thiamin pyrophospate-binding protein) t0112(thiamine-binding periplasmic protein precursor) SL1344_0108(thiamine-binding periplasmic protein precursor) Cluster2750 1 0 1 1 1 1 1 ROD_00741(thiamine ABC transport system, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3921(Sulfate transport system permease protein CysW,thiamine transporter membrane protein,ABC-type uncharacterized transport system, permease component,thiamine/thiamine pyrophosphate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component) b0067(fused thiamin transporter subunits of ABC superfamily: membrane components) BN373_05541(thiamine/thiamine pyrophosphate ABC transporter, permease protein) t0111(putative ABC transporter integral membrane protein) SL1344_0107(putative ABC transporter integral membrane protein) Cluster2751 1 0 1 1 1 1 1 ROD_00651(DNA polymerase II) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3933(DNA polymerase II,DNA polymerase II,DNA polymerase (pol2),DNA polymerase family B) b0060(DNA polymerase II) BN373_05471(DNA polymerase II) t0100(DNA polymerase II) SL1344_0098(DNA polymerase II) Cluster2752 1 0 1 1 1 1 1 ROD_00611(organic solvent tolerance protein precursor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3937(Organic solvent tolerance protein,LPS assembly outer membrane complex protein LptD,Organic solvent tolerance protein OstA,lipopolysaccharide transport periplasmic protein LptA,Organic solvent tolerance protein) b0054(LPS assembly OM complex LptDE, beta-barrel component) BN373_05381(LPS-assembly protein) t0096(organic solvent tolerance protein precursor) SL1344_0094(organic solvent tolerance protein precursor) Cluster2753 1 0 1 1 1 1 1 ROD_00551(dihydrofolate reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3945(Dihydrofolate reductase,dihydrofolate reductase,Dihydrofolate reductase) b0048(dihydrofolate reductase) BN373_05321(dihydrofolate reductase) t0090(dihydrofolate reductase type I) SL1344_0088(dihydrofolate reductase type I) Cluster2754 0 0 0 0 1 2 3 BN373_05151(oxaloacetate decarboxylase alpha subunit) t0057(oxaloacetate decarboxylase alpha chain),t3267(oxaloacetate decarboxylase alpha chain) SL1344_0056(oxaloacetate decarboxylase alpha chain),SL1344_0744(oxaloacetate decarboxylase alpha chain (ec 4.1.1.3)),SL1344_3324(oxaloacetate decarboxylase alpha chain) Cluster2755 0 0 0 0 1 2 3 BN373_05131(oxaloacetate decarboxylase beta subunit) t0056(oxaloacetate decarboxylase beta chain),t3266(oxaloacetate decarboxylase beta chain) SL1344_0055(oxaloacetate decarboxylase beta chain (ec 4.1.1.3)),SL1344_0745(oxaloacetate decarboxylase beta chain (ec 4.1.1.3)),SL1344_3323(oxaloacetate decarboxylase beta chain 2) Cluster2756 1 0 1 1 1 1 1 ROD_00261(4-hydroxy-3-methylbut-2-enyl diphosphate reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3966(4-hydroxy-3-methylbut-2-enyl diphosphate reductase,4-hydroxy-3-methylbut-2-enyl diphosphate reductase,4-hydroxy-3-methylbut-2-enyl diphosphate reductase,LytB protein) b0029(4-hydroxy-3-methylbut-2-enyl diphosphate reductase, 4Fe-4S protein) BN373_05051(4-hydroxy-3-methylbut-2-enyl diphosphate reductase) t0051(LytB protein) SL1344_0050(LytB protein) Cluster2757 1 0 1 1 1 1 1 ROD_00161(Na(+)/H(+) antiporter 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3975(Sodium/proton antiporter nhaA,pH-dependent sodium/proton antiporter,Protein-disulfide isomerase,Na+/H+ antiporter NhaA,Na+/H+ antiporter 1) b0019(sodium-proton antiporter) BN373_04981(Na+/H+ antiporter NhaA) t0041(Na(+)/H(+) antiporter 1) SL1344_0040(Na(+)/H(+) antiporter 1) Cluster2758 1 0 1 1 1 1 1 ROD_50871(inner membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3997(Inner membrane protein CreD,inner membrane protein,Inner membrane protein CreD) b4400(inner membrane protein) BN373_04801(inner membrane protein CreD) t4629(inner membrane protein CreD) SL1344_4517(inner membrane protein) Cluster2759 1 0 1 1 1 1 1 ROD_50861(two-component system sensor kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3998(Sensor protein CreC,sensory histidine kinase CreC,Uncharacterized protein conserved in bacteria,phosphate regulon sensor kinase PhoR,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b4399(sensory histidine kinase in two-component regulatory system with CreB or PhoB, regulator of the CreBC regulon) BN373_04791(sensor protein CreC) t4628(putative two-component sensor kinase) SL1344_4516(two-component sensor kinase) Cluster2760 1 0 1 1 1 1 1 ROD_50851(two-component response regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3999(Transcriptional regulatory protein CreB,DNA-binding response regulator CreB,Response regulator containing a CheY-like receiver domain and an HD-GYP domain,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain) b4398(DNA-binding response regulator in two-component regulatory system with CreC) BN373_04781(transcriptional regulatory protein CreB) t4627(putative two-component response regulator) SL1344_4515(putative two-component response regulator) Cluster2761 1 1 1 1 1 0 1 ROD_50811(conserved hypothetical protein) ENC_45190(conserved hypothetical protein TIGR00258) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4003(Non-canonical purine NTP phosphatase,inosine/xanthosine triphosphatase,inosine/xanthosine triphosphatase,Protein of unknown function DUF84) b4394(inosine/xanthosine triphosphatase) BN373_04741(conserved hypothetical protein TIGR00258) SL1344_4511(conserved hypothetical protein) Cluster2762 1 0 1 1 1 1 1 ROD_50791(soluble lytic murein transglycosylase precursor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4005(Soluble lytic murein transglycosylase precursor,lytic murein transglycosylase,Transglycosylase SLT domain) b4392(lytic murein transglycosylase, soluble) BN373_04721(transglycosylase SLT domain protein) t4621(lytic murein transglycosylase) SL1344_4509(lytic murein transglycosylase) Cluster2763 1 0 1 1 1 1 1 ROD_50781(ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4006(Uncharacterized ABC transporter ATP-binding protein YjjK,putative ABC transporter ATP-binding protein,ATP-dependent transcriptional regulator,ATP-binding cassette protein, ChvD family,ABC transporter) b4391(fused predicted transporter subunits of ABC superfamily: ATP-binding components) BN373_04711(ABC transporter, ATP-binding protein) t4620(conserved hypothetical ABC transporter) SL1344_4508(conserved hypothetical ABC transporter) Cluster2764 1 0 1 1 1 1 1 ROD_49121(DNA repair protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4008(DNA repair protein RadA,RecA-superfamily ATPases implicated in signal transduction,DNA repair protein RadA,KaiC) b4389(DNA repair protein) BN373_04691(DNA repair protein RadA) t4618(putative DNA repair protein) SL1344_4506(putative DNA repair protein) Cluster2765 1 0 1 1 1 1 1 ROD_49071(purine nucleoside phosphorylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4013(Purine nucleoside phosphorylase deoD-type,purine nucleoside phosphorylase,purine nucleoside phosphorylase,Phosphorylase superfamily) b4384(purine-nucleoside phosphorylase) BN373_04651(purine nucleoside phosphorylase) t4613(purine nucleoside phosphorylase) SL1344_4497(purine nucleoside phosphorylase) Cluster2766 1 0 1 1 1 1 1 ROD_49011(putative deoxyribonuclease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4019(Uncharacterized deoxyribonuclease YjjV,putative deoxyribonuclease YjjV,Mg-dependent DNase,hydrolase, TatD family,TatD related DNase) b4378(predicted DNase) BN373_04601(putative hydrolase) t4607(conserved hypothetical protein) SL1344_4491(conserved hypothetical protein) Cluster2767 1 0 1 1 1 1 1 ROD_49001(patatin-like phospholipase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4020(Patatin-like phospholipase) b4377(predicted phospholipase, patatin-like family) BN373_04591(phospholipase, patatin family) t4606(conserved hypothetical protein) SL1344_4490(conserved hypothetical protein) Cluster2768 1 0 1 1 1 1 1 ROD_48751(5'-nucleotidase (nucleoside 5'-monophosphate phosphohydrolase)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4024(Pyrimidine 5'-nucleotidase YjjG,dUMP phosphatase,Predicted hydrolase (HAD superfamily),HAD hydrolase,haloacid dehalogenase-like hydrolase) b4374(dUMP phosphatase) BN373_04551(5-nucleotidase YjjG) t4602(conserved hypothetical protein) SL1344_4487(conserved hypothetical protein) Cluster2769 1 0 1 1 1 1 1 ROD_48731(DNA polymerase III, psi subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4026(DNA polymerase III subunit psi,DNA polymerase III subunit psi,DNA polymerase III, psi subunit,DNA polymerase III, psi subunit,DNA polymerase III psi subunit) b4372(DNA polymerase III, psi subunit) BN373_04531(DNA polymerase III, psi subunit) t4600(DNA polymerase III, psi subunit) SL1344_4485(DNA polymerase III, psi subunit) Cluster2770 1 0 1 1 1 1 1 ROD_48631(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4035(Inner membrane protein YjjP,Protein of unknown function (DUF1212)) b4364(inner membrane protein, H-NS-repressed, DUF1212 family) BN373_04421(putative membrane protein) t4589(putative membrane protein) SL1344_4477(putative membrane protein) Cluster2771 1 0 1 1 1 1 1 ROD_48291(multidrug resistance protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4058(Multidrug resistance protein MdtM,multidrug efflux system protein MdtM,Arabinose efflux permease,drug resistance transporter, Bcr/CflA subfamily,Major Facilitator Superfamily) b4337(multidrug efflux system protein) BN373_03921(multidrug resistance protein MdtM) t4568(putative sugar transport protein) SL1344_4448(putative sugar transport protein) Cluster2772 0 1 1 1 2 0 1 ENC_35530(heavy metal sensor kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3440(Sensor kinase CusS,sensor kinase CusS,Predicted periplasmic ligand-binding sensor domain,heavy metal sensor kinase,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b0570(sensory histidine kinase in two-component regulatory system with CusR, senses copper ions) BN373_03661(sensor kinase CusS),BN373_p00581(sensor kinase CusS) pseudoSL1344_0550(Two component regulator sensor kinase (fragment)) Cluster2773 0 1 1 1 2 0 1 ENC_35480(heavy metal efflux pump (cobalt-zinc-cadmium)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3435(Cation efflux system protein CusA,multidrug efflux system subunit MdtC,heavy metal efflux pump, CzcA family,AcrB/AcrD/AcrF family) b0575(copper/silver efflux system, membrane component) BN373_03611(cation efflux system protein CusA),BN373_p00641(SilA) pseudoSL1344_0550A(cation efflux protein (pseudogene)) Cluster2774 0 0 0 0 4 0 2 BN373_03281(putative transposase-related protein),BN373_30481(OrfB),BN373_p01801(transposase),BN373_p01851(conserved hypothetical protein) pseudoSL1344_0294(transposase (pseudogene)),pseudoSL1344_2747A(putative transposase (pseudogene)) Cluster2775 1 1 1 1 1 1 0 ROD_50201(integrase) ENC_43890(Integrase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.781(Putative prophage CPS-53 integrase,integrase,Site-specific recombinase XerC,Phage integrase family) pseudob4271(unknown) BN373_03071(site-specific recombinase, phage integrase family protein) t4518(integrase) Cluster2776 1 1 1 1 1 0 1 ROD_33301(putative zinc-binding dehydrogenase) ENC_34550(Zn-dependent alcohol dehydrogenases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4187(NADP-dependent alcohol dehydrogenase C,ethanol-active dehydrogenase/acetaldehyde-active reductase,Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase,zinc-binding alcohol dehydrogenase family protein,Alcohol dehydrogenase GroES-like domain) b4269(predicted alcohol dehydrogenase, Zn-dependent and NAD(P)-binding) BN373_03031(oxidoreductase, zinc-binding dehydrogenase family) SL1344_4416(putative alcohol dehydrogenase) Cluster2777 1 0 1 1 1 1 1 ROD_33271(putative permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4190(Lipopolysaccharide export system permease protein lptF,lipopolysaccharide ABC transporter permease LptF,Predicted permeases,Predicted permease YjgP/YjgQ family) b4261(lipopolysaccharide export ABC permease of the LptBFGC export complex) BN373_02831(putative permease) t4513(putative inner membrane protein) SL1344_4409(putative inner membrane protein) Cluster2778 1 0 1 1 1 1 1 ROD_27001(putative C4-dicarboxylate anaerobic transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1412(hypothetical protein,C4-dicarboxylate anaerobic carrier) b2298(predicted inner membrane protein) BN373_02741(mfs superfamily major facilitator transporter) t0525(putative membrane protein) SL1344_2308(putative membrane protein) Cluster2779 0 1 1 1 1 1 1 ENC_43440(Soluble cytochrome b562) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4214(Soluble cytochrome b562 precursor,cytochrome b562,Soluble cytochrome b562,Cytochrome b562) pseudob4236(unknown) BN373_02431(soluble cytochrome b562) t4473(soluble cytochrome b562) SL1344_4369(soluble cytochrome b562) Cluster2780 1 0 1 1 1 1 1 ROD_32681(2',3'-cyclic-nucleotide 2'-phosphodiesterase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4235(2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor,bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein,2',3'-cyclic-nucleotide 2'-phosphodiesterase,5'-nucleotidase, C-terminal domain) b4213(2':3'-cyclic-nucleotide 2'-phosphodiesterase) BN373_02171(2',3'-cyclic-nucleotide 2'-phosphodiesterase) t4456(2',3'-cyclic-nucleotide 2'-phosphodiesterase) SL1344_4336(2',3'-cyclic-nucleotide 2'-phosphodiesterase) Cluster2781 1 0 1 1 1 1 1 ROD_32521(L-ribulose-5-phosphate 4-epimerase (L-ascorbate utilization protein F)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4258(L-ribulose-5-phosphate 4-epimerase UlaF,L-ribulose-5-phosphate 4-epimerase,Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases,L-ribulose-5-phosphate 4-epimerase,Class II Aldolase and Adducin N-terminal domain) b4198(L-ribulose 5-phosphate 4-epimerase) BN373_02021(L-ribulose-5-phosphate 4-epimerase) t4439(probable class II aldolase) SL1344_4321(probable class II aldolase) Cluster2782 1 0 1 1 1 1 1 ROD_32431(putative lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4267(putative biofilm stress and motility protein A,Protein of unknown function (DUF1471)) b4189(confers peroxide resistance in bioflms) BN373_01921(putative lipoprotein) t4430(putative exported protein) SL1344_4312(putative exported protein) Cluster2783 1 0 1 1 1 1 1 ROD_32421(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4268(putative biofilm stress and motility protein A,Protein of unknown function (DUF1471)) b4188(predicted protein) BN373_01911(conserved hypothetical protein) t4429(hypothetical protein) SL1344_4311(hypothetical protein) Cluster2784 1 1 1 1 1 1 0 ROD_32361(putative membrane protein) ENC_42770(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4280(Uncharacterized protein conserved in bacteria (DUF2065)) b4176(conserved protein, DUF2065 family) BN373_01851(conserved hypothetical protein) t4416(putative membrane protein) Cluster2785 1 0 1 1 1 1 1 ROD_32331(GTP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4283(GTP-binding protein HflX,GTPase HflX,Predicted GTPase,GTP-binding protein HflX,GTPase of unknown function) b4173(GTPase, stimulated by 50S subunit binding) BN373_01811(GTP-binding proten HflX) t4413(HflX protein, putative GTP-binding protein) SL1344_4296(HflX protein, putative GTP-binding protein) Cluster2786 1 0 1 1 1 1 1 ROD_32321(host factor-I protein (HF-I)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4284(Host factor-I protein,RNA-binding protein Hfq,RNA chaperone Hfq,LSM domain) b4172(HF-I, host factor for RNA phage Q beta replication) BN373_01801(RNA chaperone Hfq) t4412(host factor-I protein) SL1344_4295(host factor-I protein(HF-I)) Cluster2787 1 0 1 1 1 1 1 ROD_32231(probable GTPase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4295(Putative ribosome biogenesis GTPase RsgA,GTPase RsgA,ribosome small subunit-dependent GTPase A,Protein of unknown function, DUF258) b4161(ribosome small subunit-dependent GTPase A) BN373_01711(ribosome small subunit-dependent GTPase A) t4401(putative membrane protein) SL1344_4286(putative membrane protein) Cluster2788 1 0 1 1 1 1 1 ROD_32211(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4297(Potassium efflux system KefA precursor,putative mechanosensitive channel protein,Mechanosensitive ion channel inner membrane domain 1) b4159(predicted mechanosensitive channel) BN373_01691(transporter, small conductance mechanosensitive ion channel (MscS) family) t4399(putative membrane protein) SL1344_4284(putative membrane protein) Cluster2789 1 0 1 1 1 1 1 ROD_32151(fumarate reductase subunit D) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4304(Fumarate reductase 13 kDa hydrophobic protein,fumarate reductase subunit D,Fumarate reductase subunit D) b4151(fumarate reductase (anaerobic), membrane anchor subunit) BN373_01631(fumarate reductase, D subunit) t4392(fumarate reductase complex subunit D) SL1344_4277(fumarate reductase complex subunit D; membrane anchor polypeptide) Cluster2790 0 1 1 1 1 1 1 ENC_42480(Predicted small secreted protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4309(entericidin B membrane lipoprotein,Predicted small secreted protein,Entericidin EcnA/B family) b4411(entericidin B membrane lipoprotein) BN373_01601(entericidin B) t4388(entericidin B precursor) SL1344_4273(entericidin B precursor) Cluster2791 1 0 1 1 1 1 1 ROD_32091(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4313(hypothetical protein) b4145(predicted protein) BN373_01471(conserved hypothetical protein) t4384(hypothetical protein) SL1344_4269(hypothetical protein) Cluster2792 1 0 1 1 1 1 1 ROD_32041(putative permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4317(Inner membrane protein yjeH,putative transporter,amino acid transporter,Amino acid permease) b4141(predicted transporter) BN373_01421(amino acid permease family protein) t4380(putative permease) SL1344_4265(putative permease) Cluster2793 1 0 1 1 1 1 1 ROD_32001(divalent cation tolerance protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4321(C-type cytochrome biogenesis protein CycY,divalent-cation tolerance protein CutA,CutA1 divalent ion tolerance protein) b4137(divalent-cation tolerance protein, copper sensitivity) BN373_01381(divalent-cation tolerance protein CutA) t4375(periplasmic divalent cation tolerance protein CutA) SL1344_4261(periplasmic divalent cation tolerance protein CutA) Cluster2794 1 0 1 1 1 1 1 ROD_31991(thiol:disulfide interchange protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4322(Thiol:disulfide interchange protein DsbD precursor,thiol:disulfide interchange protein precursor,Thiol:disulfide interchange protein,thioredoxin,Disulphide bond corrector protein DsbC) b4136(fused thiol:disulfide interchange protein: activator of DsbC/conserved protein) BN373_01371(thiol:disulfide interchange protein DsbD) t4374(thiol:disulfide interchange protein DsbD) SL1344_4260(thiol:disulfide interchange protein DsbD) Cluster2795 1 0 1 1 1 1 1 ROD_31981(putative transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4323(HTH-type transcriptional regulator yjdC,putative transcriptional regulator,Thiol:disulfide interchange protein) b4135(predicted transcriptional regulator) BN373_01361(putative transcriptional regulator, TetR family) t4373(putative transcriptional regulator) SL1344_4259(putative transcriptional regulator) Cluster2796 1 0 1 1 1 1 1 ROD_10601(curved DNA-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2908(Curved DNA-binding protein,curved DNA-binding protein CbpA,Preprotein translocase subunit Sec63,chaperone protein DnaJ,DnaJ C terminal domain) b1000(curved DNA-binding protein, DnaJ homologue that functions as a co-chaperone of DnaK) BN373_01221(curved DNA-binding protein) t1808(curved DNA-binding protein) SL1344_1051(curved DNA-binding protein) Cluster2797 1 0 1 1 1 1 1 ROD_10591(chaperone-modulator protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2909(Chaperone modulatory protein CbpM,chaperone-modulator protein CbpM) b0999(modulator of CbpA co-chaperone) BN373_01211(chaperone-modulator protein CbpM) t1809(conserved hypothetical protein) SL1344_1050(conserved hypothetical protein) Cluster2798 0 1 1 1 1 1 1 ENC_05400(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4359(hypothetical protein,Uncharacterized protein conserved in bacteria,3-demethylubiquinone-9 3-methyltransferase) b4107(conserved protein) BN373_01131(putative phnB protein) t4195(conserved hypothetical protein) SL1344_4225(conserved hypothetical protein) Cluster2799 0 1 0 1 1 1 2 ENC_19350(P pilus assembly protein, chaperone PapD) b3143(predicted periplasmic pilin chaperone) BN373_00811(gram-negative pili assembly chaperone) t4633(putative fimbrial chaperone protein) SL1344_3605(fimbrial chaperone protein (LpfB)),SL1344_4521(putative fimbrial chaperone protein) Cluster2800 1 1 1 0 1 1 1 ROD_34521(putative LysR-family transcriptional regulator) ENC_05000(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4408(Morphology and auto-aggregation control protein,DNA-binding transcriptional regulator CynR,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) BN373_00761(transcriptional regulator, LysR family) t4176(lysR family regulatory protein) SL1344_4206(lysR family regulatory protein) Cluster2801 1 0 1 1 1 1 1 ROD_37381(methionine synthase (5-methyltetrahydrofolate-homocysteine methyltransferase)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4479(Methionine synthase,B12-dependent methionine synthase,Predicted cobalamin binding protein,methionine synthase,Homocysteine S-methyltransferase) b4019(homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent) BN373_00061(methionine synthase) t4115(B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase) SL1344_4123(B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase) Cluster2802 1 0 1 1 1 1 1 ROD_37441(homoserine O-succinyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4484(Homoserine O-succinyltransferase,homoserine O-succinyltransferase,homoserine O-succinyltransferase,Homoserine O-succinyltransferase) b4013(homoserine O-transsuccinylase) BN373_00011(homoserine O-succinyltransferase) t4110(homoserine O-succinyltransferase) SL1344_4117(homoserine O-succinyltransferase) Cluster2803 5 0 0 0 0 0 0 ROD_36011(putative polysaccharide degrading enzyme),ROD_44821(putative polysaccharide degrading enzyme),ROD_44831(putative polysaccharide degrading enzyme),ROD_44841(putative polysaccharide degrading enzyme),ROD_46591(putative polysaccharide degrading enzyme) Cluster2804 5 0 0 0 0 0 0 ROD_29871(T3SS effector protein Map),ROD_31791(T3SS effector protein EspM3),ROD_40911(T3SS effector protein EspT),ROD_40981(putative T3SS effector protein EspM2),pseudoROD_40861(putative T3SS effector protein EspM1 (pseudogene)) Cluster2805 5 0 0 0 0 0 0 ROD_07061(ISCro6 transposase),ROD_26771(ISCro6 transposase),pseudoROD_02031(ISCro6 transposase (pseudogene)),pseudoROD_06421(ISCro6 transposase (pseudogene)),pseudoROD_36261(ISCro6 transposase (pseudogene)) Cluster2806 3 0 0 1 0 0 1 ROD_02441(hypothetical prophage protein),ROD_25811(putative phage tail protein),ROD_47351(hypothetical prophage protein) pseudob1152(unknown) SL1344_1932(putative bacteriophage protein) Cluster2807 0 0 5 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.189(Tyrosine recombinase XerC,integrase/recombinase,Site-specific recombinase XerD,integron integrase,Phage integrase family),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.27(Tyrosine recombinase XerD,integrase/recombinase,Site-specific recombinase XerD,integron integrase,Phage integrase family),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.8(Tyrosine recombinase XerD,integrase/recombinase,Site-specific recombinase XerD,integron integrase,Phage integrase family),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.8(integrase/recombinase,Site-specific recombinase XerD,integron integrase),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.9(Tyrosine recombinase XerD,integrase/recombinase,Site-specific recombinase XerD,integron integrase,Phage integrase family) Cluster2808 0 0 5 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.14(Transposase and inactivated derivatives, TnpA family,Tn3 transposase DDE domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.33(Transposase and inactivated derivatives, TnpA family,Tn3 transposase DDE domain),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.15(Transposase and inactivated derivatives, TnpA family),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.16(Transposase and inactivated derivatives, TnpA family),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.17(Transposase and inactivated derivatives, TnpA family,Tn3 transposase DDE domain) Cluster2809 1 0 1 3 0 0 0 pseudoROD_29641(putative transposase (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_5_5104002-5133359.18(Transposase and inactivated derivatives, IS30 family,Integrase core domain) b0256(IS30 transposase),b1404(IS30 transposase),b4284(IS30 transposase) Cluster2810 1 0 1 1 0 1 1 ROD_42331(AraC-family transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.99(L-rhamnose operon transcriptional activator rhaR,DNA-binding transcriptional regulator AraC,Adenosine deaminase,YSIRK-targeted surface antigen transcriptional regulator,Helix-turn-helix domain) pseudob4648(unknown) t3841(putative transcriptional regulator) SL1344_3643(putative transcriptional regulator) Cluster2811 1 0 1 1 0 1 1 ROD_28921(5-keto-4-deoxyuronate isomerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.894(4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase,5-keto-4-deoxyuronate isomerase,5-keto 4-deoxyuronate isomerase,KduI/IolB family) b2843(4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase) t2928(5-keto-4-deoxyuronate isomerase) SL1344_2996(4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase) Cluster2812 1 0 1 1 0 1 1 ROD_50301(L-asparaginase 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.792(L-asparaginase 2 precursor,L-asparaginase II,L-asparaginase, type II,Asparaginase) b2957(periplasmic L-asparaginase II) t3018(L-asparaginase) SL1344_3081(L-asparaginase) Cluster2813 1 0 1 1 0 1 1 ROD_35391(hydrogenase-2 component protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.715(Hydrogenase isoenzymes formation protein hypC,hydrogenase 2 accessory protein HypG,hydrogenase assembly chaperone HypC/HupF,HupF/HypC family) b2990(hydrogenase 2 accessory protein) t3064(hydrogenase-2 component protein) SL1344_3117(hydrogenase-2 component protein) Cluster2814 1 0 1 1 0 1 1 ROD_35401(probable hydrogenase nickel incorporation protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.714(hypothetical protein,hydrogenase nickel incorporation protein HybF,Zn finger protein HypA/HybF (possibly regulating hydrogenase expression),hydrogenase nickel insertion protein HypA,Hydrogenase expression/synthesis hypA family) b2991(protein involved with the maturation of hydrogenases 1 and 2) t3065(hydrogenase-2 component protein) SL1344_3118(hydrogenase-2 component protein) Cluster2815 1 0 1 1 0 1 1 ROD_35411(hydrogenase 2 maturation protease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.712(Hydrogenase 2 maturation protease,hydrogenase 2 maturation endopeptidase,hydrogenase expression/formation protein,Hydrogenase maturation protease) b2993(maturation protease for hydrogenase 2) t3067(hydrogenase-2 component protein) SL1344_3120(hydrogenase-2 component protein) Cluster2816 1 0 1 1 0 1 1 ROD_35421(hydrogenase-2 large subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.711(Hydrogenase-2 large chain precursor,hydrogenase 2 large subunit,Coenzyme F420-reducing hydrogenase, alpha subunit,coenzyme F420 hydrogenase, subunit alpha,Nickel-dependent hydrogenase) b2994(hydrogenase 2, large subunit) t3068(hydrogenase-2 large subunit) SL1344_3121(hydrogenase-2 large subunit) Cluster2817 1 0 1 1 0 1 1 ROD_35431(probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.710(Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit,putative hydrogenase 2 b cytochrome subunit,Polysulphide reductase, NrfD) b2995(predicted hydrogenase 2 cytochrome b type component) t3069(probable hydrogenase-2 cytochrome b subunit) SL1344_3122(probable hydrogenase-2 cytochrome b subunit) Cluster2818 1 0 1 1 0 1 1 ROD_35441(hydrogenase-2 subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.709(Formate dehydrogenase-N subunit beta,hydrogenase 2 protein HybA,Uncharacterized Fe-S center protein,cytochrome c nitrite reductase, Fe-S protein,4Fe-4S dicluster domain) b2996(hydrogenase 2 4Fe-4S ferredoxin-type component) t3070(hydrogenase-2 small subunit) SL1344_3123(hydrogenase-2 small subunit) Cluster2819 1 0 1 1 0 1 1 ROD_35451(hydrogenase-2 small chain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.708(Hydrogenase-2 small chain precursor,hydrogenase 2 small subunit,Coenzyme F420-reducing hydrogenase, gamma subunit,hydrogenase (NiFe) small subunit (hydA),NADH ubiquinone oxidoreductase, 20 Kd subunit) b2997(hydrogenase 2, small subunit) t3071(hydrogenase-2 small chain protein) SL1344_3124(hydrogenase-2 small chain protein) Cluster2820 1 0 1 1 0 1 1 ROD_35931(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.644(Inner membrane protein yqiJ,Protein of unknown function (DUF1449)) b3050(inner membrane protein, DUF1449 family) t3118(putative membrane protein) SL1344_3171(putative membrane protein) Cluster2821 1 0 1 1 0 1 1 ROD_35941(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.643(Inner membrane protein yqiK,Uncharacterized protein conserved in bacteria,SPFH domain / Band 7 family) b3051(PHB family membrane protein, function unknown) t3119(putative exported protein) SL1344_3172(putative exported protein) Cluster2822 1 0 1 1 0 1 1 ROD_36061(L-tartrate dehydratase subunit alpha) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.632(L(+)-tartrate dehydratase subunit alpha,tartrate dehydratase subunit alpha,Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain,hydrolyase, tartrate alpha subunit/fumarate domain protein, Fe-S type,Fumarate hydratase (Fumerase)) b3061(L-tartrate dehydratase, alpha subunit) t3270(tartrate dehydratase) SL1344_3327(tartrate dehydratase) Cluster2823 1 0 1 1 0 1 1 ROD_36071(L-tartrate dehydratase subunit beta) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.631(L(+)-tartrate dehydratase subunit beta,L(+)-tartrate dehydratase subunit beta,Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain,hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type,Fumarase C-terminus) b3062(L-tartrate dehydratase, beta subunit) t3269(tartrate dehydratase) SL1344_3326(tartrate dehydratase) Cluster2824 1 0 1 1 0 1 1 ROD_41931(lipopolysaccharide core biosynthesis protein RfaZ) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.61(lipopolysaccharide core biosynthesis protein,Protein of unknown function DUF115) b3624(lipopolysaccharide core biosynthesis protein) t3804(lipopolysaccharide core biosynthesis protein RfaZ) SL1344_3681(lipopolysaccharide core biosynthesis protein RfaZ) Cluster2825 1 0 1 1 0 1 1 ROD_41921(lipopolysaccharide core biosynthesis protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.60(Lipopolysaccharide core heptose(II) kinase rfaY,lipopolysaccharide core biosynthesis protein,Kae1-associated kinase Bud32,Lipopolysaccharide core biosynthesis protein (WaaY)) b3625(lipopolysaccharide core biosynthesis protein) t3803(lipopolysaccharide core biosynthesis protein) SL1344_3682(lipopolysaccharide core biosynthesis protein) Cluster2826 1 0 1 1 0 1 1 ROD_41901(UDP-galactose:(glucosyl) LPS alpha-1,3-galactosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.58(Lipopolysaccharide 1,2-glucosyltransferase,lipopolysaccharide 1,3-galactosyltransferase,Glycosyl transferase family 8) b3627(UDP-D-galactose:(glucosyl)lipopolysaccharide-alpha-1,3-D-galactosyltransferase) t3801(lipopolysaccharide 1,3-galactosyltransferase) SL1344_3684(lipopolysaccharide 1,3-galactosyltransferase) Cluster2827 1 0 1 1 0 1 1 ROD_41891(lipopolysaccharide 1,6-galactosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.57(Probable poly(glycerol-phosphate) alpha-glucosyltransferase,UDP-D-galactose:(glucosyl)lipopol ysaccharide-1,6-D-galactosyltransferase,sugar transferase, PEP-CTERM/EpsH1 system associated,Glycosyl transferases group 1) b3628(UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase) t3800(lipopolysaccharide 1,6-galactosyltransferase) SL1344_3685(lipopolysaccharide 1,6-galactosyltransferase) Cluster2828 1 0 1 1 0 1 1 ROD_41871(heptosyl-I-kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.55(Lipopolysaccharide core heptose(I) kinase rfaP,lipopolysaccharide core heptose(I) kinase RfaP,Lipopolysaccharide kinase (Kdo/WaaP) family) b3630(kinase that phosphorylates core heptose of lipopolysaccharide) t3797(lipopolysaccharide core biosynthesis protein) SL1344_3687(lipopolysaccharide core biosynthesis protein) Cluster2829 1 0 1 1 0 1 1 ROD_41861(UDP-glucose:(heptosyl) LPS alpha-1,3-glucosyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.54(Lipopolysaccharide core biosynthesis protein rfaG,lipopolysaccharide 1,2-N-acetylglucosaminetransferase,Glycogen synthase,D-inositol-3-phosphate glycosyltransferase,Glycosyl transferases group 1) b3631(glucosyltransferase I) t3796(lipopolysaccharide core biosynthesis protein) SL1344_3688(lipopolysaccharide core biosynthesis protein) Cluster2830 1 0 1 1 0 1 1 ROD_46131(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.486(hypothetical protein,PhoP regulatory network protein YrbL) b3207(predicted protein) t3242(conserved hypothetical protein) SL1344_3297(conserved hypothetical protein) Cluster2831 0 0 1 0 0 3 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4714(hypothetical protein) t3352(possible exported protein),t4450(putative exported protein),t4451(putative exported protein) pseudoSL1344_3899A(putative exported protein (pseudogene)) Cluster2832 1 0 1 1 0 1 1 ROD_38821(putative aldose 1-epimerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4621(putative aldose-1-epimerase,Aldose 1-epimerase) b3879(predicted aldose-1-epimerase) t3601(conserved hypothetical protein) SL1344_3966(conserved hypothetical protein) Cluster2833 1 0 1 1 0 1 1 ROD_37901(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4546(Phosphoethanolamine transferase CptA,hypothetical protein,Predicted membrane-associated, metal-dependent hydrolase,Sulfatase) b3955(conserved inner membrane protein) t3506(putative membrane protein) SL1344_4068(putative membrane protein) Cluster2834 1 0 1 1 0 1 1 ROD_37351(peptidase E) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4475(Peptidase E,(alpha)-aspartyl dipeptidase,Peptidase E,Peptidase family S51) b4021((alpha)-aspartyl dipeptidase) t4117(peptidase E) SL1344_4125(peptidase E (pseudogene)) Cluster2835 1 0 1 1 0 1 1 ROD_34581(cytochrome c552) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4402(Cytochrome c-552 precursor,cytochrome c nitrite reductase subunit c552,Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit,formate-dependent cytochrome c nitrite reductase, c552 subunit,Cytochrome c552) b4070(nitrite reductase, formate-dependent, cytochrome) t4183(cytochrome c552 precursor) SL1344_4213(cytochrome c552, subunit of nitrite reductase complex) Cluster2836 1 0 1 1 0 1 1 ROD_34591(cytochrome c-type protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4401(Cytochrome c-type protein NrfB precursor,cytochrome c nitrite reductase pentaheme subunit,cytochrome c nitrite reductase, pentaheme subunit,Doubled CXXCH motif (Paired_CXXCH_1)) b4071(nitrite reductase, formate-dependent, penta-heme cytochrome c) t4184(cytochrome c-type protein NrfB precursor) SL1344_4214(penta-heme cytochrome c , subunit of nitrite reductase complex) Cluster2837 1 0 1 1 0 1 1 ROD_34601(cytochrome c-type biogenesis protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4400(DMSO reductase iron-sulfur subunit,tetrathionate reductase subunit B,Uncharacterized Fe-S center protein,cytochrome c nitrite reductase, Fe-S protein,4Fe-4S dicluster domain) b4072(formate-dependent nitrite reductase, 4Fe4S subunit) t4185(cytochrome c-type biogenesis protein) SL1344_4215(4Fe-4S subunit, subunit of nitrite reductase complex) Cluster2838 1 0 1 1 0 1 1 ROD_34611(cytochrome c-type biogenesis protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4399(Formate-dependent nitrite reductase, membrane component,cytochrome c nitrite reductase, NrfD subunit,Polysulphide reductase, NrfD) b4073(formate-dependent nitrite reductase, membrane subunit) t4186(cytochrome c-type biogenesis protein) SL1344_4216(subunit of nitrite reductase complex) Cluster2839 1 0 1 1 0 1 1 ROD_34621(cytochrome c-type biogenesis protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4398(Cytochrome c-type biogenesis protein CcmF,heme lyase subunit NrfE,Uncharacterized protein involved in biosynthesis of c-type cytochromes,cytochrome c-type biogenesis protein CcmF,Cytochrome C assembly protein) b4074(heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfE) t4187(cytochrome c-type biogenesis protein) SL1344_4217(formate-dependent nitrite reductase, assembly protein) Cluster2840 1 0 1 1 0 1 1 ROD_34641(formate-dependent nitrite reductase complex subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4396(Formate-dependent nitrite reductase complex subunit nrfG,formate-dependent nitrite reductase complex subunit NrfG,Cytochrome c biogenesis factor,putative PEP-CTERM system TPR-repeat lipoprotein,Tetratricopeptide repeat) b4076(heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfG) t4189(NrfG protein) SL1344_4218(activator of nitrite reductase complex) Cluster2841 1 0 1 1 0 1 1 ROD_45521(putative DNA methylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.432(DNA adenine methyltransferase YhdJ,putative methyltransferase,Adenine specific DNA methylase Mod,DNA methylase) b3262(DNA adenine methyltransferase, SAM-dependent) t3301(putative adenine-specific DNA-modification methylase) SL1344_3359(putative adenine-specific DNA-modification methylase) Cluster2842 1 0 1 1 0 1 1 ROD_33231(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4194(Inner membrane protein yjgN,Predicted membrane protein,Bacterial protein of unknown function (DUF898)) b4257(inner membrane protein, DUF898 family) t4509(putative innner membrane protein) SL1344_4404(putative innner membrane protein) Cluster2843 1 0 3 1 0 0 0 ROD_49751(putative GTP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4135(GTPase Era,GTPase Era,Predicted GTPase,ribosome-associated GTPase EngA,GTPase of unknown function),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4872(GTPase Era,tRNA modification GTPase TrmE,Predicted GTPase,ribosome-associated GTPase EngA,GTPase of unknown function),Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.26(GTPase Era,tRNA modification GTPase TrmE,Predicted GTPase,ribosome-associated GTPase EngA,GTPase of unknown function) pseudob1999(unknown) Cluster2844 1 0 3 1 0 0 0 ROD_49731(putative adhesin autotransporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4133(Fluffing protein,hypothetical protein,Type V secretory pathway, adhesin AidA,Autotransporter beta-domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4870(Fluffing protein,hypothetical protein,Type V secretory pathway, adhesin AidA,Autotransporter beta-domain),Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.24(Fluffing protein,hypothetical protein,Type V secretory pathway, adhesin AidA,Autotransporter beta-domain) b2000(CP4-44 prophage; antigen 43 (Ag43) phase-variable biofilm formation autotransporter) Cluster2845 1 0 1 1 0 1 1 ROD_48211(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4063(Uncharacterized protein conserved in bacteria,SdiA-regulated) b4333(conserved protein) t4217(putative membrane protein) SL1344_4247(putative membrane protein) Cluster2846 2 0 1 1 0 0 1 ROD_33411(putative type I restriction modification system HsdM component),ROD_34261(putative Type I restriction-modification system, methylase (M) subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4051(Type I restriction enzyme EcoKI M protein,Type I restriction-modification system methyltransferase subunit,type I restriction-modification system, M subunit,N-6 DNA Methylase) b4349(DNA methyltransferase M) SL1344_4456(type I restriction enzyme) Cluster2847 1 0 2 1 0 0 1 ROD_48491(putative zinc-binding dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4041(L-threonine 3-dehydrogenase,putative oxidoreductase,Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase,L-threonine 3-dehydrogenase,Alcohol dehydrogenase GroES-like domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.690(Sorbitol dehydrogenase,putative oxidoreductase,L-threonine 3-dehydrogenase,Alcohol dehydrogenase GroES-like domain) b4358(L-galactonate oxidoreductase) SL1344_3058(zinc binding dehydrogenase) Cluster2848 1 0 1 1 0 1 1 ROD_49021(radical SAM superfamily protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4018(4-hydroxyphenylacetate decarboxylase activating enzyme,pyruvate formate lyase-activating enzyme 1,Uncharacterized Fe-S center protein,glycine radical enzyme activase, YjjW family,Radical SAM superfamily) b4379(predicted pyruvate formate lyase activating enzyme) t4608(conserved hypothetical protein) SL1344_4492(conserved hypothetical protein) Cluster2849 1 0 1 1 0 1 1 ROD_45222(50S ribosomal subunit protein L36) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.397(Ribosomal protein B,50S ribosomal protein L36,ribosomal protein L36,Ribosomal protein L36) b3299(50S ribosomal subunit protein L36) t4086(50S ribosomal subunit protein L36) SL1344_3386(50S ribosomal subunit protein L36) Cluster2850 1 0 1 1 0 1 1 ROD_00371(transcriptional activator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3959(DNA-binding transcriptional activator CaiF,Protein of unknown function (DUF1401)) b0034(DNA-binding transcriptional activator) t0069(transcriptional activator CaiF) SL1344_0069(transcriptional activator CaiF) Cluster2851 1 0 1 1 0 1 1 ROD_00401(crotonobetainyl-CoA:carnitine CoA-transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3955(Crotonobetainyl-CoA:carnitine CoA-transferase,crotonobetainyl-CoA:carnitine CoA-transferase,Predicted acyl-CoA transferases/carnitine dehydratase,formyl-CoA transferase,CoA-transferase family III) b0038(crotonobetainyl CoA:carnitine CoA transferase) t0073(L-carnitine dehydratase) pseudoSL1344_0073(L-carnitine dehydratase) Cluster2852 1 0 1 1 0 1 1 ROD_00411(crotonobetainyl-CoA dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3954(Crotonobetainyl-CoA dehydrogenase,crotonobetainyl-CoA dehydrogenase,Rubredoxin,cyclohexanecarboxyl-CoA dehydrogenase,Acyl-CoA dehydrogenase, C-terminal domain) b0039(crotonobetaine reductase subunit II, FAD-binding) t0074(probable carnitine operon oxidoreductase CaiA) SL1344_0074(probable carnitine operon oxidoreductase CaiA) Cluster2853 1 0 1 1 0 1 1 ROD_00421(L-carnitine/gamma-butyrobetaine antiporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3953(L-carnitine/gamma-butyrobetaine antiporter,L-carnitine/gamma-butyrobetaine antiporter,transporter, betaine/carnitine/choline transporter (BCCT) family,BCCT family transporter) b0040(predicted transporter) t0075(probable carnitine transporter) SL1344_0075(probable carnitine transporter) Cluster2854 1 0 1 1 0 1 1 ROD_00441(probable electron transfer flavoprotein subunit of oxidoreductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3952(Electron transfer flavoprotein small subunit,putative electron transfer flavoprotein FixA,Electron transfer flavoprotein, beta subunit,Electron transfer flavoprotein domain) b0041(predicted electron transfer flavoprotein subunit, required for anaerobic carnitine reduction) t0076(FixA protein) SL1344_0076(probable flavoprotein subunit) Cluster2855 1 0 1 1 0 1 1 ROD_00451(probable electron transfer flavoprotein subunit of oxidoreductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3951(Electron transfer flavoprotein large subunit,putative electron transfer flavoprotein FixB,Rubredoxin,Electron transfer flavoprotein FAD-binding domain) b0042(predicted electron transfer flavoprotein, NAD/FAD-binding domain and ETFP adenine nucleotide-binding domain-like protein) t0077(FixB protein) SL1344_0077(probable flavoprotein subunit) Cluster2856 1 0 1 1 0 1 1 ROD_00461(FAD-dependent oxidoreductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3950(Electron transfer flavoprotein-ubiquinone oxidoreductase,putative oxidoreductase FixC,Bacterial lipocalin,geranylgeranyl reductase family,FAD dependent oxidoreductase) b0043(predicted oxidoreductase with FAD/NAD(P)-binding domain) t0078(FixC protein) SL1344_0078(probable flavoprotein subunit) Cluster2857 1 0 1 1 0 1 1 ROD_00471(ferredoxin like protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3949(ferredoxin-like protein FixX,Ferredoxin-like protein) b0044(predicted 4Fe-4S ferredoxin-type protein) t0079(ferredoxin like protein FixX) SL1344_0079(ferredoxin like protein FixX) Cluster2858 1 0 1 1 0 1 1 ROD_00491(major facilitator superfamily protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3948(Inner membrane metabolite transport protein ygcS,D-xylose transporter XylE,Arabinose efflux permease,cation transport protein,Sugar (and other) transporter) b0045(predicted transporter) t0080(putative metabolite transport protein) SL1344_0080(putative metabolite transport protein) Cluster2859 1 0 1 1 0 1 1 ROD_33371(putative type I restriction modification system HsdS component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3693(Type I restriction enzyme EcoKI specificity protein,EcoKI restriction-modification system protein HsdS,Predicted nucleotidyltransferases,Type I restriction modification DNA specificity domain) b4348(specificity determinant for hsdM and hsdR) t4574(subunit S of type I restriction-modification system) SL1344_4455(type I restriction enzyme) Cluster2860 1 0 1 1 0 1 1 ROD_03931(propionate catabolism operon regulatory protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3636(Propionate catabolism operon regulatory protein,propionate catabolism operon regulatory protein PrpR,Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,propionate catabolism operon regulatory protein PrpR,Sigma-54 interaction domain) b0330(propionate catabolism operon regulatory protein) t2497(propionate catabolism operon regulatory protein) SL1344_0362(propionate catabolism operon regulatory protein) Cluster2861 1 0 1 1 0 1 1 ROD_03941(methylisocitrate lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3635(Methylisocitrate lyase,2-methylisocitrate lyase,Isocitrate lyase,methylisocitrate lyase,Isocitrate lyase family) b0331(2-methylisocitrate lyase) t2496(putative carboxyvinyl-carboxyphosphonate phosphorylmutase) SL1344_0363(carboxyvinyl-carboxyphosphonate phosphorylmutase) Cluster2862 1 0 1 1 0 1 1 ROD_03951(2-methylcitrate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3634(2-methylcitrate synthase,methylcitrate synthase,2-methylcitrate synthase/citrate synthase II,Citrate synthase) b0333(2-methylcitrate synthase) t2495(methylcitrate synthase) SL1344_0364(methylcitrate synthase) Cluster2863 1 0 1 1 0 1 1 ROD_03961(2-methylcitrate dehydratase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3633(2-methylcitrate dehydratase,2-methylcitrate dehydratase,2-methylcitrate dehydratase,MmgE/PrpD family) b0334(2-methylcitrate dehydratase) t2494(PrpD protein) SL1344_0365(PrpD protein) Cluster2864 1 0 1 1 0 1 1 ROD_03971(propionate--coA ligase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3632(Acetyl-coenzyme A synthetase,propionyl-CoA synthetase,Uncharacterized protein conserved in bacteria,propionate--CoA ligase,AMP-binding enzyme) b0335(propionate--CoA ligase) t2493(PrpE protein) SL1344_0366(PrpE protein) Cluster2865 1 0 1 1 0 1 1 ROD_05341(acetyl esterase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3505(Acetyl esterase,acetyl esterase,alpha/beta hydrolase fold) b0476(acetyl esterase) t2370(acetyl esterase) SL1344_0483(acetyl esterase) Cluster2866 1 0 1 1 0 1 1 ROD_50741(LysR-family transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3475(HTH-type transcriptional activator AllS,DNA-binding transcriptional activator AllS,transcriptional regulator, ArgP family,LysR substrate binding domain) b0504(DNA-binding transcriptional activator of the allD operon) t2346(hypothetical lysR-family transcriptional regulator) SL1344_0507(hypothetical lysR-family transcriptional regulator) Cluster2867 1 0 1 1 0 1 1 ROD_50711(FdrA protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3461(hypothetical protein,membrane protein FdrA,Succinyl-CoA synthetase, alpha subunit,succinate-CoA ligase, alpha subunit,CoA-ligase) b0518(multicopy suppressor of dominant negative ftsH mutations; predicted acyl-CoA synthetase with NAD(P)-binding Rossmann-fold domain) t2332(FdrA protein) SL1344_0522(FdrA protein) Cluster2868 1 0 1 1 0 1 1 ROD_50721(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3460(Protein of unknown function (DUF1116)) pseudob4572(unknown) t2331(conserved hypothetical protein) SL1344_0523(conserved hypothetical protein) Cluster2869 1 0 1 1 0 1 1 ROD_50731(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3459(Protein of unknown function (DUF2877)) b0520(conserved protein) t2330(conserved hypothetical protein) SL1344_0524(conserved hypothetical protein) Cluster2870 1 0 1 1 0 1 1 ROD_50691(carbamate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3458(Carbamate kinase 1,carbamate kinase,Predicted archaeal kinase,carbamate kinase,Amino acid kinase family) b0521(predicted carbamate kinase) t2329(carbamate kinase) SL1344_0525(carbamate kinase) Cluster2871 1 0 1 1 0 1 1 ROD_20151(protease 7 precursor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3444(Protease 7 precursor,outer membrane protease,Outer membrane protease,Omptin family) b0565(DLP12 prophage; outer membrane protease VII (outer membrane protein 3b)) t0463(outer membrane protease E) SL1344_2363(outer membrane protease E) Cluster2872 1 0 1 1 0 1 1 ROD_06271(citrate carrier) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3386(Citrate/succinate antiporter,transporter, divalent anion:Na+ symporter (DASS) family,Sodium:sulfate symporter transmembrane region) b0612(citrate:succinate antiporter) t2249(citrate carrier) SL1344_0606(citrate carrier) Cluster2873 1 0 1 1 0 1 1 ROD_06281(2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3385(triphosphoribosyl-dephospho-CoA synthase,Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase),triphosphoribosyl-dephospho-CoA synthase CitG,ATP:dephospho-CoA triphosphoribosyl transferase) b0613(2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase) t2248(CitG protein) SL1344_0607(triphosphoribosyl-dephospho-CoA synthase) Cluster2874 1 0 1 1 0 1 1 ROD_06291(apo-citrate lyase phosphoribosyl-dephospho-CoA transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3384(2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-c itrate lyase,Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase),holo-ACP synthase CitX,Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase) b0614(apo-citrate lyase phosphoribosyl-dephospho-CoA transferase) t2247(conserved hypothetical protein) SL1344_0608(apo-citrate lyase phosphoribosyl-dephospho-coa transferase (ec 2.7.7.61) (holo-acp synthase) (holo-citrate lyase synthase) (apo-acp nucleodityltransferase)) Cluster2875 1 0 1 1 0 1 1 ROD_06321(citrate lyase acyl carrier protein (citrate lyase gamma chain)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3381(Citrate lyase gamma chain,citrate lyase subunit gamma,Citrate lyase, gamma subunit,citrate lyase acyl carrier protein,Malonate decarboxylase delta subunit (MdcD)) b0617(citrate lyase, acyl carrier (gamma) subunit) t2244(citrate lyase acyl carrier protein) SL1344_0611(citrate lyase acyl carrier protein) Cluster2876 1 0 1 1 0 1 1 ROD_44421(probable nitrite transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.328(Probable nitrite transporter,nitrite transporter NirC,Formate/nitrite family of transporters,formate/nitrite transporter,Formate/nitrite transporter) b3367(nitrite transporter) t4029(putative nitrite transporter) SL1344_3443(putative nitrite transporter) Cluster2877 1 0 1 1 0 1 1 ROD_44401(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.326(hypothetical protein) b3369(small lipoprotein) t4026(conserved hypothetical protein) SL1344_3447(conserved hypothetical protein) Cluster2878 1 0 1 1 0 1 1 ROD_07661(putative Sodium:sulfate symporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3228(Inner membrane protein ybhI,transporter, divalent anion:Na+ symporter (DASS) family,Sodium:sulfate symporter transmembrane region) b0770(predicted transporter) t3086(possible membrane transport protein) SL1344_3140(possible membrane transport protein) Cluster2879 2 0 3 0 0 0 0 ROD_19881(putative phage tail tape measure protein),ROD_36551(putative phage tail tape measure protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3097(Phage-related minor tail protein,phage tail tape measure protein, TP901 family, core region,Phage-related minor tail protein),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.8(Phage-related minor tail protein,phage tail tape measure protein, TP901 family, core region,Phage-related minor tail protein),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.9(Phage-related minor tail protein,phage tail tape measure protein, TP901 family, core region) Cluster2880 2 0 2 0 0 1 0 ROD_19901(phage DNA invertase),ROD_36571(phage DNA-invertase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3095(DNA-invertase hin,multiple promoter invertase,Resolvase, N terminal domain),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.11(DNA-invertase hin,multiple promoter invertase,Resolvase, N terminal domain) t1346(DNA-invertase) Cluster2881 0 0 1 1 0 1 2 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2928(Hydrogenase-1 small chain precursor,hydrogenase 2 small subunit,Coenzyme F420-reducing hydrogenase, gamma subunit,hydrogenase (NiFe) small subunit (hydA),NADH ubiquinone oxidoreductase, 20 Kd subunit) b0972(hydrogenase 1, small subunit) t1458(uptake hydrogenase small subunit) SL1344_1468(uptake hydrogenase small subunit),SL1344_1714(hydrogenase-1 small subunit) Cluster2882 0 0 1 1 0 1 2 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2927(Hydrogenase-1 large chain,hydrogenase 1 large subunit,Coenzyme F420-reducing hydrogenase, alpha subunit,coenzyme F420 hydrogenase, subunit alpha,Nickel-dependent hydrogenase) b0973(hydrogenase 1, large subunit) t1089(hydrogenase-1 large chain) SL1344_1467(uptake hydrogenase-1 large subunit),SL1344_1715(hydrogenase-1 large chain (nifE hydrogenase)) Cluster2883 1 0 1 1 0 1 1 ROD_10951(curli production assembly/transport component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2878(curli production assembly/transport protein CsgG,Curli production assembly/transport component CsgG) b1037(curli production assembly/transport outer membrane lipoprotein) t1781(assembly/transport component in curli production) SL1344_1076(assembly/transport component in curli production) Cluster2884 1 0 1 1 0 1 1 ROD_10961(curli production assembly/transport component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2877(curli assembly protein CsgF,Curli production assembly/transport component CsgF) b1038(outer membrane protein required for curli nucleation by CsgB) t1780(assembly/transport component in curli production) SL1344_1077(assembly/transport component in curli production) Cluster2885 1 0 1 1 0 1 1 ROD_10971(curli production assembly/transport component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2876(curli assembly protein CsgE,Curli assembly protein CsgE) b1039(curlin secretion specificity factor) t1779(assembly/transport component in curli production) SL1344_1078(assembly/transport component in curli production) Cluster2886 1 0 1 1 0 1 1 ROD_11051(putative phospholipase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2869(Cardiolipin synthase,cardiolipin synthetase,cardiolipin synthase) b1046(predicted hydrolase) t1772(conserved hypothetical protein) SL1344_1085(conserved hypothetical protein) Cluster2887 1 0 1 1 0 1 1 ROD_11241(glutaredoxin 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2852(Glutaredoxin-2,glutaredoxin 2,glutaredoxin, GrxB family,Glutaredoxin 2, C terminal domain) b1064(glutaredoxin 2 (Grx2)) t1755(glutaredoxin 2) SL1344_1102(glutaredoxin 2) Cluster2888 0 0 1 2 0 0 2 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2755(Bacteriophage lysis protein) b0556(DLP12 prophage; predicted murein endopeptidase),pseudob1362(unknown) SL1344_0967(putative bacteriophage lysozyme),SL1344_1955(putative bacteriophage endopeptidase) Cluster2889 1 0 1 1 0 1 1 ROD_18241(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2689(Cyclic di-GMP binding protein YcgR,Predicted glycosyltransferase,Flagellar regulator YcgR) b1194(flagellar velocity braking protein, c-di-GMP-regulated) t1079(conserved hypothetical protein) SL1344_1726(conserved hypothetical protein) Cluster2890 1 0 1 1 0 1 1 ROD_18231(transglycosylase associated protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2688(hypothetical protein,Transglycosylase associated protein) b1195(predicted inner membrane protein) t1080(putative membrane protein) SL1344_1725(putative membrane protein) Cluster2891 0 0 1 2 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2547(hypothetical protein) b4533(hypothetical protein, Qin prophage),b4589(hypothetical protein) t1827(conserved hypothetical protein) SL1344_1031(conserved hypothetical protein) Cluster2892 1 0 2 0 0 1 1 ROD_47381(phage tail fibre assembly protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2521(Caudovirales tail fibre assembly protein),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.14(Caudovirales tail fibre assembly protein) t1867(putative bacteriophage tail protein) pseudoSL1344_0990(unknown) Cluster2893 1 0 1 1 0 1 1 ROD_17171(osmotically inducible lipoprotein B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2481(lipoprotein,Glycine zipper 2TM domain) b1283(lipoprotein) t1618(osmotically inducible lipoprotein B precursor) SL1344_1637(osmotically inducible lipoprotein B precursor) Cluster2894 1 0 1 1 0 1 1 ROD_14821(major facilitator superfamily protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2305(Proline porter II,shikimate transporter,Arabinose efflux permease,MFS transporter, metabolite:H+ symporter (MHS) family protein,Major Facilitator Superfamily) pseudob4600(unknown) t1428(putative membrane transport protein) pseudoSL1344_1437(putative membrane transport protein (pseudogene)) Cluster2895 1 0 1 1 0 1 1 ROD_13841(putative oxidoreductase, cytochrome b subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2211(thiosulfate reductase cytochrome B subunit,Ni/Fe-hydrogenase, b-type cytochrome subunit,Prokaryotic cytochrome b561) b1670(predicted cytochrome) t0811(thiosulfate reductase cytochrome b subunit) SL1344_2039(thiosulfate reductase cytochrome b subunit) Cluster2896 1 0 1 1 0 1 1 ROD_13481(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2172(Cyclic di-GMP regulator CdgR,cyclic-di-GMP phosphodiesterase,EAL domain) b1707(probable cyclic di-GMP regulator, inactive EAL family phosphodiesterase) t1225(conserved hypothetical protein) SL1344_1278(conserved hypothetical protein) Cluster2897 1 0 1 1 0 1 1 ROD_12981(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2120(Protein of unknown function (DUF1496)) b1760(conserved protein, DUF1496 family) t1179(putative exported protein) SL1344_1235(putative exported protein) Cluster2898 1 0 1 1 0 1 1 ROD_12551(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2085(hypothetical protein,Domain of unknown function (DUF1869)) b1796(predicted protein) t1150(conserved hypothetical protein) SL1344_1207(conserved hypothetical protein) Cluster2899 1 0 1 1 0 1 1 ROD_18861(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2037(hypothetical protein,hypothetical protein) b1847(secreted protein) t0996(putative exported protein) SL1344_1815(putative exported protein) Cluster2900 1 0 1 1 0 1 1 ROD_19331(methyl-accepting chemotaxis protein II (aspartate chemoreceptor protein)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1996(Aspartate chemoreceptor protein,methyl-accepting chemotaxis protein II,Predicted periplasmic ligand-binding sensor domain,Methyl-accepting chemotaxis protein (MCP) signaling domain) b1886(methyl-accepting chemotaxis protein II) t0958(methyl-accepting chemotaxis protein II) SL1344_1854(methyl-accepting chemotaxis protein II) Cluster2901 1 0 2 1 0 0 1 ROD_26011(putative phage terminase large subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1951(Bacteriophage tail assembly protein,Phage terminase large subunit (GpA)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2750(Bacteriophage tail assembly protein,Phage terminase large subunit (GpA)) pseudob4634(unknown) SL1344_2572(predicted bacteriophage protein) Cluster2902 0 0 1 1 0 0 3 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1919(exonuclease VIII) b1350(Rac prophage; exonuclease VIII, 5'-> 3' specific dsDNA exonuclease) SL1344_0946(exodeoxyribonuclease viii),SL1344_2597(exodeoxyribonuclease VIII),pseudoSL1344_1805(bacteriophage encoded Exodeoxyribonuclease VIII (fragment)) Cluster2903 1 0 1 1 0 1 1 ROD_20211(flagellum-specific ATP synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1882(Flagellum-specific ATP synthase,flagellum-specific ATP synthase,F0F1-type ATP synthase, beta subunit,ATPase FliI/YscN family,ATP synthase alpha/beta family, nucleotide-binding domain) b1941(flagellum-specific ATP synthase) t0905(flagellum-specific ATP synthase) SL1344_1901(flagellum-specific ATP synthase) Cluster2904 1 0 1 1 0 1 1 ROD_20291(flagellar biosynthesis protein FliQ) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1874(Flagellar biosynthetic protein FliQ,flagellar biosynthesis protein FliQ,Type III secretory pathway, component EscS,flagellar biosynthetic protein FliQ,Bacterial export proteins, family 3) b1949(flagellar biosynthesis protein) t0897(flagellar biosynthetic protein FliQ) SL1344_1909(flagellar biosynthetic protein FliQ) Cluster2905 1 0 1 1 0 1 1 ROD_20301(flagellar biosynthesis protein FliR) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1873(Flagellar biosynthetic protein fliR,flagellar biosynthesis protein FliR,Flagellar biosynthesis pathway, component FliR,flagellar biosynthetic protein FliR,Bacterial export proteins, family 1) b1950(flagellar export pore protein) t0896(flagellar biosynthetic protein FliR) SL1344_1910(flagellar biosynthetic protein FliR) Cluster2906 1 0 2 1 0 0 1 ROD_26301(putative prophage exonuclease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1793(Exodeoxyribonuclease 8,exonuclease VIII),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2580(Exodeoxyribonuclease 8,exonuclease VIII) pseudob1577(unknown) SL1344_1974(predicted bacteriophage protein) Cluster2907 1 0 1 1 0 1 1 ROD_10531(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1769(Probable transcriptional regulatory protein YeeN,hypothetical protein,DNA-binding regulatory protein, YebC/PmpR family,Domain of unknown function DUF28) b1983(conserved protein, UPF0082 family) t4549(conserved hypothetical protein) SL1344_4429(conserved hypothetical protein) Cluster2908 1 0 4 0 0 0 0 ROD_49841(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1743(Protein of unknown function (DUF3279)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4141(Protein of unknown function (DUF3279)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4878(Protein of unknown function (DUF3279)),Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.31(Protein of unknown function (DUF3279)) Cluster2909 0 0 5 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1720(Transposase and inactivated derivatives,Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2526(Transposase and inactivated derivatives,Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4127(Transposase and inactivated derivatives,Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.939(Transposase and inactivated derivatives,Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.9(Transposase and inactivated derivatives,Integrase core domain) Cluster2910 1 0 1 1 0 1 1 ROD_42931(putative cytochrome C peroxidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.172(Cytochrome c551 peroxidase precursor,Cytochrome c, mono- and diheme variants,di-heme enzyme, MXAN_0977 family,Di-haem cytochrome c peroxidase) b3518(predicted cytochrome C peroxidase) t3698(probable cytochrome c peroxidase) SL1344_3786(probable cytochrome c peroxidase) Cluster2911 1 0 1 1 0 1 1 ROD_21651(chain length determinant protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1685(Polysaccharide antigen chain regulator,chain length determinant protein WzzB,Capsular polysaccharide biosynthesis protein,Chain length determinant protein) b2027(regulator of length of O-antigen component of lipopolysaccharide chains) t0794(polysaccharide chain length regulator) SL1344_2056(polysaccharide chain length regulator) Cluster2912 1 0 1 1 0 1 1 ROD_21741(dTDP-4-dehydrorhamnose 3,5-epimerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1675(dTDP-4-dehydrorhamnose 3,5-epimerase,dTDP-4-dehydrorhamnose 3,5-epimerase,dTDP-4-dehydrorhamnose 3,5-epimerase) b2038(dTDP-4-deoxyrhamnose-3,5-epimerase) t0778(dTDP-4-dehydrorhamnose 3,5-epimerase) SL1344_2071(dTDP-4-dehydrorhamnose 3,5-epimerase) Cluster2913 1 0 1 1 0 1 1 ROD_21861(putative colanic acid biosynthesis glycosyl transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1662(putative glycosyl transferase,colanic acid biosynthesis glycosyltransferase WcaI,Glycosyl transferases group 1) b2050(predicted glycosyl transferase) t0766(putative glycosyl transferase) SL1344_2083(putative glycosyltransferase) Cluster2914 1 0 1 1 0 1 1 ROD_21891(GDP-mannose 4,6-dehydratase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1659(GDP-mannose 4,6-dehydratase,dTDP-glucose 4,6-dehydratase,GDP-mannose 4,6-dehydratase,NAD dependent epimerase/dehydratase family) b2053(GDP-D-mannose dehydratase, NAD(P)-binding) t0763(GDP-mannose 4,6-dehydratase) SL1344_2086(GDP-mannose 4,6-dehydratase) Cluster2915 1 0 1 1 0 1 1 ROD_21941(putative acetyl transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1654(Serine acetyltransferase,putative acyl transferase,Acetyltransferase (isoleucine patch superfamily),colanic acid biosynthesis acetyltransferase WcaB,Bacterial transferase hexapeptide (six repeats)) b2058(predicted acyl transferase) t0758(putative acetyltransferase) SL1344_2091(putative acetyltransferase) Cluster2916 1 0 1 1 0 1 1 ROD_22031(putative signal transduction protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1644(Cyclic di-GMP phosphodiesterase Gmr,putative diguanylate cyclase,Predicted integral membrane sensor domain,PAS domain S-box protein,GGDEF domain) b2067(predicted diguanylate cyclase, GGDEF domain signaling protein) t0749(putative membrane protein) SL1344_2100(putative membrane protein) Cluster2917 1 0 1 1 0 1 1 ROD_46881(galactitol utilisation operon repressor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1625(Lactose phosphotransferase system repressor,DNA-bindng transcriptional repressor SrlR,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,Bacterial regulatory proteins, deoR family) pseudob4498(unknown) t3182(galactitol utilization operon repressor) SL1344_3235(galactitol utilization operon repressor) Cluster2918 1 0 1 1 0 1 1 pseudoROD_46891(galactitol-1-phosphate dehydrogenase (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1624(Sorbitol dehydrogenase,galactitol-1-phosphate dehydrogenase,L-threonine 3-dehydrogenase,Alcohol dehydrogenase GroES-like domain) b2091(galactitol-1-phosphate dehydrogenase, Zn-dependent and NAD(P)-binding) t3181(galactitol-1-phosphate dehydrogenase) SL1344_3234(galactitol-1-phosphate dehydrogenase) Cluster2919 1 0 1 1 0 1 1 ROD_47471(component IIC of galactitol-specific phosphotransferase system) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1623(PTS system galactitol-specific EIIC component,PTS system, galactitol-specific IIC component,PTS system sugar-specific permease component) b2092(galactitol-specific enzyme IIC component of PTS) t3180(galactitol-specific IIC component of PTS system) SL1344_3233(PTS system, galactitol-specific IIC component) Cluster2920 1 0 1 1 0 1 1 ROD_47481(component IIB of galactitol-specific phosphotransferase system) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1621(Galactitol-specific phosphotransferase enzyme IIB component,PTS system galactitol-specific transporter subunit IIB,Phosphotransferase system, galactitol-specific IIB component,PTS system, Lactose/Cellobiose specific IIB subunit) b2093(galactitol-specific enzyme IIB component of PTS) t3179(galactitol-specific IIB component of PTS system) SL1344_3232(PTS system, galactitol-specific IIB component) Cluster2921 1 0 1 1 0 1 1 ROD_47491(component IIA of galactitol-specific phosphotransferase system) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1620(PTS system galactitol-specific transporter subunit IIA,PTS system, fructose subfamily, IIA component,Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2) b2094(galactitol-specific enzyme IIA component of PTS) t3178(galactitol-specific IIA component of PTS system) SL1344_3231(PTS system, galactitol-specific IIA component) Cluster2922 1 0 1 1 0 1 1 ROD_22251(putative carbohydrate/pyrimidine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1614(5-dehydro-2-deoxygluconokinase,ribokinase,Unchara cterized protein conserved in bacteria,ribokinase,pfkB family carbohydrate kinase) b2100(predicted kinase) t0712(putative sugar kinase) SL1344_2121(putative sugar kinase) Cluster2923 1 0 1 1 0 1 1 ROD_22261(GntR-family transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1613(Uncharacterized HTH-type transcriptional regulator yegW,DNA-binding transcriptional regulator FrlR,Transcriptional regulators,phosphonate metabolism transcriptional regulator PhnF,UTRA domain) b2101(predicted DNA-binding transcriptional regulator) t0711(putative GntR-family transcriptional regulator) SL1344_2122(putative gntR-family transcriptional regulator) Cluster2924 1 0 1 1 0 1 1 ROD_22311(putative fimbrial adhesin) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1602(putative fimbrial-like adhesin protein StcD) b2108(predicted fimbrial-like adhesin protein) t0707(putative exported protein) SL1344_2126(putative exported protein) Cluster2925 1 0 1 1 0 1 1 ROD_22341(putative major fimbrial subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1599(fimbrial chaperone protein,P pilus assembly protein, pilin FimA) b2111(predicted fimbrial-like adhesin protein) t0704(putative fimbrial subunit protein) SL1344_2129(putative fimbrial subunit protein) Cluster2926 0 0 3 2 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1593(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1594(WGR domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1595(WGR domain) b2118(conserved protein),pseudob4499(unknown) Cluster2927 1 0 1 1 0 1 1 ROD_22401(MerR-family transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1582(HTH-type transcriptional repressor YcgE,transcriptional regulator MirA,Zn(II)-responsive transcriptional regulator,MerR family regulatory protein) b2127(DNA-binding transcriptional regulator) t0695(putative transcriptional regulator) SL1344_2138(putative transcriptional regulator) Cluster2928 1 0 1 1 0 1 1 ROD_22601(putative short-chain dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1571(3-oxoacyl-[acyl-carrier-protein] reductase FabG,oxidoreductase,Uncharacterized conserved protein,3-oxoacyl-[acyl-carrier-protein] reductase,short chain dehydrogenase) b2137(predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain) t0684(putative oxidoreductase) SL1344_2149(putative oxidoreductase) Cluster2929 1 0 1 1 0 1 1 ROD_22741(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1564(Protein of unknown function (DUF2542)) b2145(conserved protein, DUF2542 family) t0670(putative membrane protein) SL1344_2162(putative membrane protein) Cluster2930 1 0 1 1 0 1 1 ROD_23241(nitrate/nitrite response regulator protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1516(Nitrate/nitrite response regulator protein narL,transcriptional regulator NarP,Response regulator,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain) b2193(DNA-binding response regulator in two-component regulatory system with NarQ or NarX) t0618(nitrate/nitrite response regulator protein) SL1344_2222(nitrate/nitrite response regulator protein NarP) Cluster2931 1 0 1 1 0 1 1 ROD_23331(cytochrome C-type protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1507(Cytochrome c-type protein NapC,cytochrome c-type protein NapC,periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family,NapC/NirT cytochrome c family, N-terminal region) b2202(Quinol dehydrogenase, electron source for NapAB) t0609(cytochrome c-type protein NapC) SL1344_2225(cytochrome c-type protein NapC) Cluster2932 1 0 1 1 0 1 1 ROD_23341(diheme cytochrome C protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1506(Diheme cytochrome c NapB precursor,nitrate reductase cytochrome C550 subunit,Nitrate reductase cytochrome c-type subunit (NapB)) b2203(nitrate reductase, small, cytochrome C550 subunit, periplasmic) t0608(cytochrome c-type protein NapB precursor) SL1344_2226(cytochrome c-type protein NapB precursor) Cluster2933 1 0 1 1 0 1 1 ROD_23351(ferredoxin-type protein NapH) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1505(Putative electron transport protein yccM,quinol dehydrogenase membrane component,ferredoxin-type protein, NapH/MauN family,4Fe-4S binding domain) b2204(ferredoxin-type protein essential for electron transfer from ubiquinol to periplasmic nitrate reductase (NapAB)) t0607(ferredoxin-type protein NapH) SL1344_2227(ferredoxin-type protein NapH) Cluster2934 1 0 1 1 0 1 1 ROD_23361(ferredoxin-type protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1504(quinol dehydrogenase periplasmic component,MauM/NapG family ferredoxin-type protein,4Fe-4S dicluster domain) b2205(ferredoxin-type protein essential for electron transfer from ubiquinol to periplasmic nitrate reductase (NapAB)) t0606(ferredoxin-type protein NapG) SL1344_2228(ferredoxin-type protein NapG) Cluster2935 1 0 1 1 0 1 1 ROD_23371(periplasmic nitrate reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1503(Periplasmic nitrate reductase precursor,nitrate reductase catalytic subunit,Uncharacterized anaerobic dehydrogenase,periplasmic nitrate reductase, large subunit,Molybdopterin oxidoreductase) b2206(nitrate reductase, periplasmic, large subunit) t0605(probable nitrate reductase) SL1344_2229(probable nitrate reductase) Cluster2936 1 0 1 1 0 1 1 ROD_23381(putative napAB assembly protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1502(hypothetical protein,assembly protein for periplasmic nitrate reductase,NapD protein) b2207(assembly protein for periplasmic nitrate reductase) t0603(putative napAB assembly protein) SL1344_2230(putative napAB assembly protein) Cluster2937 1 0 1 1 0 1 1 ROD_23391(ferredoxin-type protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1501(ferredoxin-type protein,Uncharacterized Fe-S center protein,ferredoxin-type protein NapF,4Fe-4S dicluster domain) b2208(ferredoxin-type protein, role in electron transfer to periplasmic nitrate reductase NapA) t0604(ferredoxin-type protein NapF) SL1344_2231(ferredoxin-type protein NapF) Cluster2938 1 0 1 1 0 1 1 ROD_26661(putative aluminum inducible exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1456(lipopolysaccharide core heptose(II)-phosphate phosphatase,Histidine phosphatase superfamily (branch 1)) b2252(predicted LPS core heptose(II)-phosphate phosphatase) t0567(Ais protein) SL1344_2265(hypothetical protein (protein induced by aluminum)) Cluster2939 1 0 1 1 0 1 1 ROD_42681(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.145(Inner membrane transport protein YhjV,threonine/serine transporter TdcC,serine transporter) b3539(predicted transporter) t3890(putative amino acid permease) SL1344_3591(putative amino acid permease) Cluster2940 1 0 1 1 0 1 1 ROD_34991(putative fimbrial chaperone protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1375(Chaperone protein papD precursor,putative fimbrial chaperone protein StfD,Gram-negative pili assembly chaperone, N-terminal domain) b2336(predicted periplasmic pilus chaperone) t2858(periplasmic fimbrial chaperone) SL1344_0198(periplasmic fimbrial chaperone stfd) Cluster2941 1 0 1 1 0 1 1 ROD_23871(putative short-chain dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1293(3-oxoacyl-[acyl-carrier-protein] reductase FabG,short chain dehydrogenase,Uncharacterized conserved protein,3-oxoacyl-[acyl-carrier-protein] reductase,short chain dehydrogenase) b2426(predicted short-chain oxidoreductase) t0413(putative oxidoreductase) SL1344_2408(putative oxidoreductase) Cluster2942 0 0 1 0 0 2 2 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1229(RatA-like protein,Salmonella repeat of unknown function (DUF823)) t0341(putative exported protein),t0343(conserved hypothetical protein) SL1344_2477(putative exported protein (RatA)),pseudoSL1344_2475(putative outer membrane protein (RatB) (pseudogene)) Cluster2943 0 1 1 1 0 1 1 ENC_47510(L-ribulose 5-phosphate 4-epimerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.100(L-ribulose-5-phosphate 4-epimerase SgbE,L-ribulose-5-phosphate 4-epimerase,Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases,L-ribulose-5-phosphate 4-epimerase,Class II Aldolase and Adducin N-terminal domain) b3583(L-ribulose-5-phosphate 4-epimerase) t3842(putative sugar isomerase) SL1344_3642(putative sugar isomerase) Cluster2944 0 1 1 1 0 1 1 ENC_47500(hexulose-6-phosphate isomerase, putative) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.101(L-ribulose-5-phosphate 3-epimerase ulaE,putative L-xylulose 5-phosphate 3-epimerase,Hydroxypyruvate isomerase,putative hexulose-6-phosphate isomerase,Xylose isomerase-like TIM barrel) b3582(predicted L-xylulose 5-phosphate 3-epimerase) t3843(putative sugar-phosphate isomerase) SL1344_3641(putative sugar-phosphate isomerase) Cluster2945 0 1 1 1 0 1 1 ENC_47490(3-hexulose-6-phosphate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.102(3-keto-L-gulonate-6-phosphate decarboxylase sgbH,3-keto-L-gulonate-6-phosphate decarboxylase,3-hexulose-6-phosphate synthase,Orotidine 5'-phosphate decarboxylase / HUMPS family) b3581(3-keto-L-gulonate 6-phosphate decarboxylase) t3844(putative hexulose-6-phosphate synthase) SL1344_3640(putative hexulose-6-phosphate synthase) Cluster2946 0 1 1 1 0 1 1 ENC_47450(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.108(hypothetical protein,uncharacterized protein, YhcH/YjgK/YiaL family,Domain of unknown function (DUF386)) b3576(conserved protein) t3850(conserved hypothetical protein) SL1344_3634(conserved hypothetical protein) Cluster2947 0 1 1 1 0 1 1 ENC_47440(Malate/L-lactate dehydrogenases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.109(2,3-diketo-L-gulonate reductase,2,3-diketo-L-gulonate reductase,Malate/L-lactate dehydrogenases,ureidoglycolate dehydrogenase,Malate/L-lactate dehydrogenase) b3575(2,3-diketo-L-gulonate reductase, NADH-dependent) t3851(putative carboxylic acid dehydrogenase) SL1344_3633(putative carboxylic acid dehydrogenase) Cluster2948 0 1 1 1 0 1 1 ENC_47430(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.110(YiaKLMNOPQRS operon repressor,DNA-binding transcriptional regulator KdgR,beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family,Bacterial transcriptional regulator) b3574(DNA-binding transcriptional repressor of yiaK-S operon) t3852(putative transcriptional regulator) SL1344_3632(putative transcriptional regulator) Cluster2949 1 1 1 1 0 0 1 ROD_48461(methyl-accepting chemotaxis protein) ENC_44750(Methyl-accepting chemotaxis protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4044(Serine chemoreceptor protein,methyl-accepting chemotaxis protein I,Predicted periplasmic ligand-binding sensor domain,TMAO reductase sytem sensor TorS,Methyl-accepting chemotaxis protein (MCP) signaling domain) b4355(methyl-accepting chemotaxis protein I, serine sensor receptor) SL1344_4464(methyl-accepting chemotaxis protein) Cluster2950 2 1 1 1 0 0 0 ROD_43481(Hcp family T6SS protein CtsH2),ROD_43831(Hcp family T6SS protein CtsH3) ENC_44150(S-type Pyocin./HNH endonuclease.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3877(Pyocin-S2,Pyocin large subunit,type VI secretion system effector, Hcp1 family,DNase/tRNase domain of colicin-like bacteriocin) b3442(conserved protein) Cluster2951 0 1 1 2 0 0 1 ENC_43810(probable dehydratase, YjhG/YagF family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4107(hypothetical protein,putative dehydratase,Dihydroxyacid dehydratase/phosphogluconate dehydratase,putative dehydratase, YjhG/YagF family,Dehydratase family) b0269(CP4-6 prophage; predicted dehydratase),b4297(KpLE2 phage-like element; predicted dehydratase) SL1344_3498(putative dehydratase) Cluster2952 1 1 1 1 0 0 1 ROD_21811(putative colanic acid biosynthesis pyruvyl transferase) ENC_41210(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1667(colanic acid biosynthesis protein,colanic acid biosynthesis pyruvyl transferase WcaK,Polysaccharide pyruvyl transferase) b2045(Colanic acid biosynthesis protein) SL1344_2078(colanic acid biosynthesis protein) Cluster2953 1 1 1 1 0 0 1 ROD_21921(putative colanic acid polymerase) ENC_41090(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1656(putative colanic acid biosynthesis protein,putative colanic acid polymerase WcaD) b2056(predicted colanic acid polymerase) SL1344_2089(colanic acid polymerase) Cluster2954 1 1 1 0 0 1 1 ROD_31451(putative membrane protein) ENC_39470(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4675(Tripartite tricarboxylate transporter TctA family) t2683(putative membrane protein) SL1344_2772(putative membrane protein) Cluster2955 2 1 0 1 0 0 1 ROD_15311(hypothetical protein),pseudoROD_40772(putative transposase (fragment)) ENC_35990(Integrase core domain.) pseudob1567(unknown) pseudoSL1344_1483(transposase (pseudogene)) Cluster2956 1 1 1 1 0 0 1 ROD_45512(predicted membrane protein yhdu) ENC_35120(Protein of unknown function (DUF2556).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.431(Protein of unknown function (DUF2556)) b3263(predicted membrane protein) SL1344_3360(putative exported protein) Cluster2957 1 1 1 1 0 0 1 ROD_47651(putative membrane protein) ENC_33640(Amino acid permeases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.582(Inner membrane transport protein YhaO,threonine/serine transporter TdcC,serine transporter) b3110(predicted transporter) SL1344_3211(putative membrane transport protein) Cluster2958 1 1 0 0 0 2 1 ROD_05651(conserved hypothetical protein) ENC_33170(DnaJ-domain-containing proteins 1) t2294(hypothetical protein),t2295(hypothetical protein) SL1344_0555(conserved hypothetical protein) Cluster2959 1 1 1 0 0 1 1 ROD_43511(2,3-diketo-L-gulonate TRAP transporter, large permease protein) ENC_26620(TRAP transporter, DctM subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.794(Neu5Ac permease,L-dehydroascorbate transporter large permease subunit,TRAP-type C4-dicarboxylate transport system, small permease component,TRAP transporter, DctM subunit,DctM-like transporters) t3567(possible integral membrane transport protein) SL1344_4001(putative membrane transport protein) Cluster2960 1 1 1 1 0 0 1 ROD_45301(conserved hypothetical protein) ENC_25060(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.405(Alternative ribosome-rescue factor A,Domain of unknown function) b4550(conserved protein, DUF331 family) SL1344_3378(conserved hypothetical protein) Cluster2961 0 1 2 2 0 0 0 ENC_24160(Lysis protein S.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1818(Lysis protein S),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2554(Lysis protein S) b0554(DLP12 prophage; predicted phage lysis protein),b1556(Qin prophage; predicted S lysis protein) Cluster2962 1 1 0 1 0 1 1 ROD_06381(cold shock-like protein) ENC_20870(cold shock protein E (CspE)) b0623(DNA-binding transcriptional repressor) t2238(cold shock-like protein cspE) SL1344_0617(cold shock-like protein cspE) Cluster2963 0 1 3 0 0 0 1 ENC_17060(lambda-like phage minor tail protein L) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1839(phage minor tail protein L,Phage minor tail protein L),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2531(phage minor tail protein L,Phage minor tail protein L),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2735(phage minor tail protein L,Phage minor tail protein L) SL1344_2556(predicted bacteriophage protein) Cluster2964 0 1 1 1 0 1 1 ENC_15680(Flagellar hook capping protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2841(Basal-body rod modification protein flgD,flagellar basal body rod modification protein,Flagellar hook capping protein,Flagellar hook capping protein) b1075(flagellar hook assembly protein) t1744(flagellar hook formation protein FlgD) SL1344_1113(flagellar hook formation protein FlgD) Cluster2965 0 1 1 1 0 1 1 ENC_15670(fagellar hook-basal body proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2840(Flagellar hook protein flgE,flagellar hook protein FlgE,Flagellar hook protein FlgE,flagellar hook-basal body protein,Flagellar basal body protein FlaE) b1076(flagellar hook protein) t1743(flagellar hook protein FlgE) SL1344_1114(flagellar hook protein FlgE) Cluster2966 0 1 1 1 0 1 1 ENC_15640(Flagellar basal body L-ring protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2837(Basal body L-ring protein,flagellar basal body L-ring protein,Flagellar L-ring protein) b1079(flagellar protein of basal-body outer-membrane L ring) t1740(flagellar L-ring protein precursor) SL1344_1117(Flagellar L-ring protein precursor) Cluster2967 0 1 1 1 0 1 1 ENC_15630(Flagellar basal-body P-ring protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2836(Basal body P-ring protein,flagellar basal body P-ring protein,Flagellar basal-body P-ring protein,Flagellar P-ring protein) b1080(predicted flagellar basal body protein) t1739(flagellar P-ring protein precursor) SL1344_1118(Flagellar P-ring protein precursor) Cluster2968 1 1 1 0 0 1 1 ROD_00181(putative glycosyl hydrolase) ENC_14840(Alpha-glucosidases, family 31 of glycosyl hydrolases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3973(Alpha-xylosidase,putative alpha-glucosidase,Alpha-galactosidase,Glycosyl hydrolases family 31) t0043(putative glycosyl hydrolase) SL1344_0042(putative glycosyl hydrolase) Cluster2969 0 1 1 1 0 1 1 ENC_12070(D-mannonate dehydratase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2303(Starvation-sensing protein rspA,bifunctional D-altronate/D-mannonate dehydratase,L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily,muconate and chloromuconate cycloisomerases,Mandelate racemase / muconate lactonizing enzyme, N-terminal domain) b1581(bifunctional D-altronate/D-mannonate dehydratase) t1426(starvation sensing protein RspA) SL1344_1435(starvation sensing protein RspA) Cluster2970 0 2 1 1 0 1 0 ENC_11550(Alkyl sulfatase and related hydrolases),ENC_31120(Alkyl sulfatase and related hydrolases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4382(Metallo-beta-lactamase superfamily) b4083(conserved protein, metallo-beta-lactamase superfamily) t1012(putative hydrolase) Cluster2971 2 1 0 0 0 1 1 ROD_25731(putative membrane fusion protein of T1SS),ROD_48191(putative membrane fusion protein of T1SS) ENC_11240(type I secretion membrane fusion protein, HlyD family) t2646(putative type I secretion protein) SL1344_2664(putative type I secretion protein) Cluster2972 1 1 0 0 0 1 2 ROD_27741(Hcp family T6SS protein Cts1H) ENC_07260(type VI secretion system effector, Hcp1 family) t2584(conserved hypothetical protein) SL1344_0271(conserved hypothetical protein (SPI-6 associated)),SL1344_0274(conserved hypothetical protein (SPI-6 associated)) Cluster2973 1 1 0 0 0 2 1 ROD_27841(T6SS protein Cts1A) ENC_07230(type VI secretion-associated protein, ImpA family) t2598(hypothetical protein),t2599(hypothetical protein) SL1344_0260(conserved hypothetical protein (SPI-6 associated)) Cluster2974 1 1 2 1 0 0 0 ROD_12811(putative sugar-bisphosphate aldolase) ENC_05120(fructose-bisphosphate aldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2107(Probable fructose-bisphosphate aldolase,tagatose-bisphosphate aldolase,Fructose/tagatose bisphosphate aldolase,ketose-bisphosphate aldolase,Fructose-bisphosphate aldolase class-II),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.27(Probable fructose-bisphosphate aldolase,hypothetical protein,Fructose/tagatose bisphosphate aldolase,fructose-1,6-bisphosphate aldolase, class II,Fructose-bisphosphate aldolase class-II) b1773(predicted aldolase) Cluster2975 1 1 0 0 0 1 2 ROD_35011(putative fimbrial adhesin) ENC_04110(P pilus assembly protein, pilin FimA) t3662(probable fimbrial protein) SL1344_0175(fimbrial protein),pseudoSL1344_3602(putative fimbrial protein (LpfD),fimbrial protein (LpfD) (pseudogene)) Cluster2976 1 1 1 1 0 0 1 ROD_22321(fimbrial usher protein) ENC_03280(P pilus assembly protein, porin PapC) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1601(Heat shock protein E,fimbrial outer membrane usher protein,Fimbrial Usher protein) b2109(predicted outer membrane protein) SL1344_2127(putative outer membrane usher protein) Cluster2977 1 1 0 1 0 1 1 ROD_29071(putative exported protein) ENC_02970(hypothetical protein) b2848(predicted protein) t3759(putative exported protein) SL1344_3724(putative exported protein) Cluster2978 1 1 0 1 0 1 1 ROD_42491(cold shock protein) ENC_01650(cold-shock DNA-binding protein family) b3556(RNA chaperone and anti-terminator, cold-inducible) t3870(cold shock protein) SL1344_3615(cold shock protein) Cluster2979 1 1 0 1 0 0 2 ROD_49081(putative exported protein) ENC_00470(Protein of unknown function (DUF1120).) b3219(predicted transcriptional regulator) SL1344_4501(putative outer membrane protein),SL1344_4502(putative outer membrane protein) Cluster2980 1 1 0 1 0 1 1 ROD_38871(putative glycosyl hydrolase) ENC_00270(Alpha-glucosidases, family 31 of glycosyl hydrolases) b3878(alpha-glucosidase) t3602(putative glycosyl hydrolase) SL1344_3965(putative glycosyl hydrolase) Cluster2981 0 1 1 1 0 1 1 ENC_00240(Oligogalacturonate-specific porin protein (KdgM).) Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.43(Porin NanC,outer membrane porin L,Oligogalacturonate-specific porin protein (KdgM)) b3875(outer membrane porin L) t3605(conserved hypothetical protein) SL1344_3962(conserved hypothetical protein) Cluster2982 1 1 1 1 1 0 0 ROD_34371(iron(III) dicitrate TonB-dependent receptor) ENC_36620(TonB-dependent siderophore receptor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4151(Iron(III) dicitrate transport protein FecA,vitamin B12/cobalamin outer membrane transporter,Outer membrane receptor for Fe3+-dicitrate,TonB-dependent siderophore receptor,TonB dependent receptor) b4291(KpLE2 phage-like element; ferric citrate outer membrane transporter) BN373_p02221(ferric citrate outer membrane transporter) Cluster2983 1 1 1 1 1 0 0 ROD_34391(RNA polymerase sigma factor) ENC_36650(RNA polymerase sigma factor, sigma-70 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4149(Probable RNA polymerase sigma factor fecI,RNA polymerase sigma factor FecI,RNA polymerase sigma factor, sigma-70 family,Sigma-70, region 4) b4293(KpLE2 phage-like element; RNA polymerase, sigma 19 factor) BN373_p02201(RNA polymerase sigma factor FecI) Cluster2984 0 0 4 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1727(Transposase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4172(Transposase),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.132(Transposase),Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.36(Transposase) BN373_p01701(conserved hypothetical protein) Cluster2985 1 0 0 0 1 2 1 ROD_35281(conserved hypothetical protein) BN373_p01381(conserved hypothetical protein) t4223(conserved hypothetical protein),t4358(hypothetical protein) SL1344_4253(conserved hypothetical protein) Cluster2986 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3468(Allantoinase,allantoinase,N-acyl-D-aspartate/D-gl utamate deacylase,allantoinase,Amidohydrolase family) b0512(allantoinase) BN373_p00901(dihydroorotase) t2338(putative allantoinase) SL1344_0516(allantoinase) Cluster2987 0 0 2 0 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.138(tRNA(fMet)-specific endonuclease VapC,plasmid maintenance protein,PIN domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.141(tRNA(fMet)-specific endonuclease VapC,plasmid maintenance protein,PIN domain) BN373_p00181(conserved hypothetical protein) t2943(hypothetical protein) SL1344_3011(hypothetical protein (assiciated with virulence)) Cluster2988 0 0 2 0 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.137(Antitoxin VapB,Virulence-associated protein and related proteins,SpoVT / AbrB like domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.140(Antitoxin VapB,Virulence-associated protein and related proteins,SpoVT / AbrB like domain) BN373_p00171(conserved hypothetical protein) t2944(hypothetical protein) SL1344_3012(hypothetical protein (assiciated with virulence)) Cluster2989 1 0 1 1 1 1 0 ROD_39581(glucose-1-phosphate thymidylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4736(Glucose-1-phosphate thymidylyltransferase 2,glucose-1-phosphate thymidylyltransferase RfbA,GTP:adenosylcobinamide-phosphate guanylyltransferase,glucose-1-phosphate thymidylyltransferase,Nucleotidyl transferase) b3789(glucose-1-phosphate thymidylyltransferase) BN373_49171(glucose-1-phosphate thymidylyltransferase) t3374(glucose-1-phosphate thymidylyltransferase) Cluster2990 1 1 0 0 1 1 1 ROD_38531(putative DNA binding protein) ENC_00530(Predicted transcriptional regulators) BN373_48341(DNA-binding protein) t3577(putative DNA-binding protein) SL1344_3991(putative DNA-binding protein) Cluster2991 1 1 0 0 1 1 1 ROD_38541(AzlC-like membrane protein) ENC_00520(Predicted branched-chain amino acid permease (azaleucine resistance)) BN373_48331(AzlC family protein) t3578(putative exported protein) SL1344_3990(putative exported protein) Cluster2992 1 1 0 0 1 1 1 ROD_38551(putative membrane protein) ENC_00510(Branched-chain amino acid transport protein (AzlD).) BN373_48321(putative membrane protein) t3579(hypothetical protein) SL1344_3989(putative exported protein) Cluster2993 0 1 1 1 1 1 0 ENC_00380(Ribbon-helix-helix protein, copG family.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4608(hypothetical protein) b3890(conserved protein) BN373_48171(ribbon-helix-helix protein, CopG family) t3588(putative CopG-family DNA-binding protein) Cluster2994 1 0 0 1 1 1 1 ROD_38901(putative lipopolysaccharide core biosynthesis GTP-binding protein) b3871(GTP-binding protein) BN373_48111(GTP-binding protein TypA/BipA) t3613(GTP-binding protein) SL1344_3955(GTP-binding protein) Cluster2995 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4808(HTH-type transcriptional regulator yidZ,DNA-binding transcriptional regulator YidZ,LysR substrate binding domain) b3711(predicted DNA-binding transcriptional regulator) BN373_47571(transcriptional regulator, LysR family) t3675(putative LysR-family transcriptional regulator) SL1344_3815(putative LysR-family transcriptional regulator) Cluster2996 1 0 1 1 1 0 1 ROD_40321(2-dehydro-3-deoxy-6-phosphogalactonate aldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4825(2-dehydro-3-deoxy-6-phosphogalactonate aldolase,2-dehydro-3-deoxy-6-phosphogalactonate aldolase,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase,KDPG and KHG aldolase) b4477(2-oxo-3-deoxygalactonate 6-phosphate aldolase) BN373_47401(2-dehydro-3-deoxy-6-phosphogalactonate aldolase) SL1344_3795(2-dehydro-3-deoxy-6-phosphogalactonate aldolase (ec 4.1.2.21) (6-phospho-2-dehydro-3-deoxygalactonate aldolase) (2-oxo-3-deoxygalactonate 6-phosphate aldolase)) Cluster2997 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4840(Anaerobic sulfatase-maturating enzyme,anaerobic sulfatase-maturase,anaerobic sulfatase maturase) b3674(predicted DNA-binding transcriptional regulator) BN373_47261(conserved hypothetical protein) t3714(conserved hypothetical protein) SL1344_3771(conserved hypothetical protein) Cluster2998 2 0 1 1 1 0 0 ROD_07651(conserved hypothetical protein),ROD_31661(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3229(3-methylitaconate isomerase,probable AcnD-accessory protein PrpF,PrpF protein) b0769(conserved protein) BN373_46901(putative fldA protein) Cluster2999 1 1 0 0 1 1 1 ROD_41201(putative acetyltransferase) ENC_03360(Predicted acetyltransferase) BN373_46801(acetyltransferase, GNAT family) t1020(putative acetyltransferase) SL1344_1787(putative acetyltransferase) Cluster3000 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3664(Regulatory protein soxS,transcriptional activator FtrA,DNA gyrase inhibitor,Cupin) b0305(predicted DNA-binding transcriptional regulator) BN373_46731(transcriptional regulator, AraC family) t2299(hypothetical araC-family transcriptional regulator) SL1344_0551(hypothetical araC-family transcriptional regulator) Cluster3001 1 1 1 1 1 0 0 ROD_12821(putative sugar kinase) ENC_01620(Sugar kinases, ribokinase family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2108(Uncharacterized sugar kinase ydjH,ribokinase,Uncharacterized protein conserved in bacteria,ribokinase,pfkB family carbohydrate kinase) b1772(predicted kinase) BN373_45491(kinase, pfkB family) Cluster3002 1 0 1 1 1 0 1 ROD_42771(cellulose synthase operon protein C (TPR-repeat-containing protein)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.160(Cellulose synthase operon protein C precursor,cellulose synthase subunit BcsC,Flp pilus assembly protein TadD, contains TPR repeats,putative PEP-CTERM system TPR-repeat lipoprotein,Cellulose synthase operon protein C C-terminus (BCSC_C)) b3530(cellulose synthase subunit) BN373_45171(cellulose synthase operon protein C) SL1344_3581(putative polysaccharide biosynthesis protein subunit C) Cluster3003 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1454(Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase,undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase,Predicted glycosyl hydrolase,glycosyltransferase,Glycosyl transferase family 2) b2254(undecaprenyl phosphate-L-Ara4FN transferase) BN373_44811(undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase) t0565(putative lipopolysaccharide modification protein) SL1344_2267(putative lipopolysaccharide modification protein) Cluster3004 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1449(Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF,4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF) b2258(undecaprenyl phosphate-alpha-L-ara4N exporter; flippase ArnEF subunit) BN373_44761(putative membrane protein) t0560(putative membrane protein) SL1344_2272(putative membrane protein) Cluster3005 1 0 0 1 1 1 1 ROD_45231(30S ribosomal subunit protein S13) b3298(30S ribosomal subunit protein S13) BN373_43351(ribosomal protein S13) t4087(30S ribosomal subunit protein S13) SL1344_3385(30S ribosomal subunit protein S13) Cluster3006 1 1 1 1 1 0 0 ROD_47931(exu regulon transcriptional regulator) ENC_33510(transcriptional regulator, GntR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.596(L-lactate utilization operon repressor,DNA-binding transcriptional repressor ExuR,Transcriptional regulators,phosphonate metabolism transcriptional regulator PhnF,Bacterial regulatory proteins, gntR family) b3094(DNA-binding transcriptional repressor) BN373_41851(Exu regulon transcriptional regulator) Cluster3007 1 1 1 1 1 0 0 ROD_47961(altronate hydrolase) ENC_33480(D-altronate dehydratase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.599(D-galactarate dehydratase,galactarate dehydratase,D-galactarate dehydratase / Altronate hydrolase, C terminus) b3091(altronate hydrolase) BN373_41811(altronate dehydratase) Cluster3008 0 1 0 1 1 1 1 ENC_33410(Sugar (pentulose and hexulose) kinases) b1511(autoinducer-2 (AI-2) kinase) BN373_41711(autoinducer-2 kinase) t3546(putative sugar kinase) SL1344_4021(putative sugar kinase) Cluster3009 0 1 0 1 1 1 1 ENC_33400(Transcriptional regulator, contains sigma factor-related N-terminal domain) b1512(lsr operon transcriptional repressor) BN373_41701(transcriptional repressor LsrR) t3545(putative regulatory protein) SL1344_4022(putative regulatory protein) Cluster3010 0 1 0 1 1 1 1 ENC_33390(autoinducer 2 ABC transporter ATP-binding protein) b1513(Autoinducer 2 import ATP-binding protein) BN373_41691(autoinducer-2 ABC transporter, ATP-binding protein LsrA) t3544(putative ABC transporter ATP-binding protein) SL1344_4023(putative ABC transporter ATP-binding protein) Cluster3011 0 1 0 1 1 1 1 ENC_33380(autoinducer 2 ABC transporter membrane protein) b1514(Autoinducer 2 import system permease protein) BN373_41681(autoinducer-2 ABC transporter, permease protein LsrC) t3543(putative ABC transporter permease protein) SL1344_4024(putative ABC transporter permease protein) Cluster3012 0 1 0 1 1 1 1 ENC_33370(autoinducer 2 ABC transporter membrane protein) b1515(autoinducer 2 import system permease protein) BN373_41671(autoinducer-2 ABC transporter, permease protein LsrD) t3542(putative ABC transporter, membrane component) SL1344_4025(putative ABC transporter, membrane component) Cluster3013 0 1 0 1 1 1 1 ENC_33360(autoinducer 2-binding protein) b1516(autoinducer 2-binding protein) BN373_41661(autoinducer-2 ABC transporter, periplasmic autoinducer-2-binding protein LsrB) t3541(putative ABC transport protein, solute-binding component) SL1344_4026(putative ABC transport protein, solute-binding component) Cluster3014 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1341(hypothetical protein,hypothetical protein,YfdX protein) b2375(predicted protein) BN373_41351(conserved hypothetical protein) t2941(conserved hypothetical protein) SL1344_3009(conserved hypothetical protein) Cluster3015 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.681(DNA gyrase inhibitor,DNA gyrase inhibitor,Bacterial transcription activator, effector binding domain) b3023(transcriptional repressor for mcbR biofilm gene) BN373_40901(transcriptional regulator, AraC family) t3096(possible AraC-family transcriptional regulator) SL1344_3149(possible AraC-family transcriptional regulator) Cluster3016 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.707(Protein of unknown function (DUF2623)) b2998(predicted protein) BN373_40751(conserved hypothetical protein) t3072(conserved hypothetical protein) SL1344_3125(conserved hypothetical protein) Cluster3017 1 1 1 1 1 0 0 ROD_29051(conserved hypothetical protein) ENC_30980(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4341(Uncharacterized conserved protein,Protein of unknown function (DUF1271)) b4126(conserved protein) BN373_39281(conserved hypothetical protein) Cluster3018 1 1 1 1 1 0 0 ROD_29041(conserved hypothetical protein) ENC_30970(Predicted acetyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4331(hypothetical protein) b4127(predicted acyltransferase with acyl-CoA N-acyltransferase domain) BN373_39271(conserved hypothetical protein) Cluster3019 1 1 1 1 1 0 0 ROD_29171(fimbrial minor subunit FimG) ENC_19380(P pilus assembly protein, pilin FimA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4078(hypothetical protein,putative fimbrial protein SthD,P pilus assembly protein, pilin FimA,Fimbrial protein) b4319(minor component of type 1 fimbriae) BN373_39241(fimbrial protein FimG) Cluster3020 1 1 0 0 1 1 1 pseudoROD_28941(putative exported protein (pseudogene)) ENC_30920(Oligogalacturonate-specific porin protein (KdgM).) BN373_38981(putative oligogalacturonate-specific porin) t1789(putative secreted protein) SL1344_1069(putative secreted protein) Cluster3021 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4072(Pyruvate dehydrogenase complex repressor,DNA-binding transcriptional repressor UxuR,Transcriptional regulators,phosphonate utilization associated transcriptional regulator,FCD domain) b4324(DNA-binding transcriptional repressor) BN373_38791(transcriptional regulator, GntR family) t4556(uxu operon transcriptional regulator) SL1344_4437(uxu operon transcriptional regulator) Cluster3022 1 0 0 1 1 1 1 ROD_21421(propanediol utilization protein PduV) pseudob4538(unknown) BN373_38511(propanediol utilization protein PduV) t0818(putative propanediol utilization protein PduV) SL1344_2032(putative propanediol utilization protein PduV) Cluster3023 1 0 0 0 2 1 1 ROD_21291(propanediol utilization diol dehydratase reactivation protein) BN373_38381(propanediol utilization diol dehydratase reactivation protein),BN373_41391(glycerol dehydratase reactivation factor, large subunit) t0831(PduG protein) SL1344_2019(propanediol utilization protein) Cluster3024 1 0 0 0 2 1 1 ROD_21261(glycerol dehydratase large subunit) BN373_38351(propanediol utilization dehydratase, large subunit),BN373_41421(glycerol dehydratase, large subunit) t0834(glycerol dehydratase large subunit) SL1344_2016(glycerol dehydratase large subunit) Cluster3025 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.974(L-fucose permease,L-fucose transporter,Arabinose efflux permease,L-fucose:H+ symporter permease,Major Facilitator Superfamily) b2801(L-fucose transporter) BN373_37991(L-fucose:H+ symporter permease) t2883(L-fucose permease) SL1344_2955(L-fucose permease) Cluster3026 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.976(Lactaldehyde reductase,L-1,2-propanediol oxidoreductase,Glycerol dehydrogenase and related enzymes,lactaldehyde reductase,Iron-containing alcohol dehydrogenase) b2799(L-1,2-propanediol oxidoreductase) BN373_37971(lactaldehyde reductase) t2881(1,2-propanediol oxidoreductase) SL1344_2953(1,2-propanediol oxidoreductase (lactaldehyde reductase)) Cluster3027 1 1 0 0 1 1 1 ROD_30691(MarR-family transcriptional regulator) ENC_29910(transcriptional regulator, MarR family) BN373_37431(transcriptional regulator HosA) t2821(putative regulatory protein) SL1344_2899(putative regulatory protein) Cluster3028 1 1 0 0 1 1 1 ROD_30701(putative 4-hydroxybenzoate decarboxylase subunit B) ENC_29900(polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases) BN373_37421(4-hydroxybenzoate decarboxylase, subunit B) t2822(possible decarboxylase) SL1344_2900(possible decarboxylase) Cluster3029 1 1 0 0 1 1 1 ROD_30711(putative 4-hydroxybenzoate decarboxylase subunit C) ENC_29890(UbiD family decarboxylases) BN373_37411(4-hydroxybenzoate decarboxylase, subunit C) t2823(conserved hypothetical protein) SL1344_2901(conserved hypothetical protein) Cluster3030 1 1 0 0 1 1 1 ROD_30721(putative 4-hydroxybenzoate decarboxylase subunit D) ENC_29880(hypothetical protein) BN373_37401(4-hydroxybenzoate decarboxylase, subunit D) t2824(conserved hypothetical protein) SL1344_2902(conserved hypothetical protein) Cluster3031 2 0 0 0 1 1 1 ROD_20691(putative DNA binding protein),pseudoROD_31951(putative DNA binding protein (pseudogene)) BN373_37361(DNA-binding prophage protein) t4367(hypothetical protein) SL1344_2744(DNA-binding bacteriophage protein) Cluster3032 1 1 0 0 1 1 1 ROD_30751(iron ABC transporter, permease protein) ENC_21520(ABC-type Mn2+/Zn2+ transport systems, permease components) BN373_37141(iron ABC transporter, permease protein AfeD) t2766(iron transport protein, inner membrane component) SL1344_2844(Iron transport protein, inner membrane component) Cluster3033 1 1 0 0 1 1 1 ROD_41161(putative glycosyl hydrolase) ENC_03470(aryl-phospho-beta-glucosidase) BN373_37021(glycosyl hydrolase, family 1) t3743(putative glycosyl hydrolase) SL1344_3740(putative glycosyl hydrolase) Cluster3034 0 2 1 0 1 1 0 ENC_04130(P pilus assembly protein, chaperone PapD),ENC_47690(P pilus assembly protein, chaperone PapD) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3832(Chaperone protein fimC precursor,fimbrial assembly chaperone SthB,Gram-negative pili assembly chaperone, N-terminal domain) BN373_36251(gram-negative pili assembly chaperone protein) t3660(fimbrial chaperone protein) Cluster3035 1 1 1 1 1 0 0 ROD_25551(outer membrane lipoprotein) ENC_28020(Outer membrane protein and related peptidoglycan-associated (lipo)proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1136(Outer membrane protein OmpAb,putative outer membrane lipoprotein,Outer membrane protein and related peptidoglycan-associated (lipo)proteins,type VI secretion system OmpA/MotB family protein,OmpA family) b2605(probable positive effector of YfiN activity, OM lipoprotein) BN373_35801(OmpA family protein) Cluster3036 1 1 0 0 1 1 1 ROD_25401(conserved hypothetical protein) ENC_27960(gluconolactonase) BN373_35751(SMP-30/gluconolactonase/LRE family protein) t2623(conserved hypothetical protein) SL1344_2626(conserved hypothetical protein) Cluster3037 1 1 0 0 1 1 1 ROD_24791(putative exported protein) ENC_37190(ABC-type uncharacterized transport system, periplasmic component) BN373_35251(conserved hypothetical protein) t0304(putative exported protein) SL1344_2514(putative exported protein) Cluster3038 1 1 0 0 1 1 1 ROD_42291(putative sugar kinase) ENC_47580(Transcriptional regulator/sugar kinase) BN373_34821(beta-glucoside kinase) t3838(putative sugar kinase) SL1344_3646(putative sugar kinase) Cluster3039 1 1 1 1 1 0 0 ROD_24221(putative esterase) ENC_38000(Predicted esterase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1256(putative hydrolase,Predicted esterase,Phospholipase/Carboxylesterase) b2473(predicted hydrolase) BN373_34661(esterase, AB hydrolase 2 family) Cluster3040 1 0 1 1 1 0 1 ROD_24051(ethanolamine utilization protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1273(Ethanolamine utilization protein EutM precursor,carboxysome structural protein EutM,Carbon dioxide concentrating mechanism/carboxysome shell protein,PduT-like ethanolamine utilization protein,BMC domain) b2457(predicted carboxysome structural protein, ethanolamine utilization protein) BN373_34501(ethanolamine utilization protein EutM) SL1344_2428(ethanolamine utilization protein) Cluster3041 1 0 0 1 1 1 1 ROD_28141(putative signal transduction protein) b2395(predicted diguanylate cyclase) BN373_34091(diguanylate cyclase/cyclic diguanylate phosphodiesterase) t0447(putative membrane protein) SL1344_2378(putative membrane protein) Cluster3042 1 1 0 0 1 1 1 ROD_28081(putative decarboxylase) ENC_38590(indolepyruvate decarboxylase, Erwinia family) BN373_34041(indole-3-pyruvate decarboxylase) t0452(putative decarboxylase) SL1344_2373(putative decarboxylase) Cluster3043 1 1 1 1 1 0 0 ROD_27961(two-component system response regulator) ENC_38620(Response regulator of the LytR/AlgR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1335(hypothetical protein,two-component response regulator,Response regulator of the LytR/AlgR family,sporulation transcription factor Spo0A,LytTr DNA-binding domain) b2381(predicted response regulator in two-component system with YpdA) BN373_34011(DNA-binding response regulator) Cluster3044 1 1 1 1 1 0 0 ROD_27111(D-erythro-7,8-dihydroneopterin triphosphate epimerase) ENC_39050(FolB domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1407(D-erythro-7,8-dihydroneopterin triphosphate epimerase,D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase,FolB domain,Dihydroneopterin aldolase) b2303(D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase) BN373_33031(D-erythro-7,8-dihydroneopterin triphosphate epimerase) Cluster3045 1 0 1 1 1 0 1 ROD_21491(penicillin-binding protein 6B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1704(D-alanyl-D-alanine carboxypeptidase dacD precursor,D-alanyl-D-alanine carboxypeptidase,D-alanyl-D-alanine carboxypeptidase) b2010(D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 6b)) BN373_30701(serine-type D-Ala-D-Ala carboxypeptidase) SL1344_2038(penicillin-binding protein) Cluster3046 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1448(Polymyxin resistance protein pmrD,signal transduction protein PmrD,Polymyxin resistance protein PmrD) b2259(inactive two-component system connector protein) BN373_30261(signal transduction protein PmrD) t0559(polymyxin B resistance protein) SL1344_2273(polymyxin B resistance protein) Cluster3047 1 1 1 1 1 0 0 ROD_20651(nitrogen assimilation regulatory protein) ENC_41720(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1764(HTH-type transcriptional regulator gltC,nitrogen assimilation transcriptional regulator,pca operon transcription factor PcaQ,LysR substrate binding domain) b1988(DNA-binding transcriptional dual regulator of nitrogen assimilation) BN373_30201(nitrogen assimilation regulatory protein Nac) Cluster3048 1 0 0 1 1 1 1 ROD_20431(Outer membrane porin protein) pseudob4496(unknown) BN373_30141(outer membrane protein, gram-negative porin family) t0883(outer membrane protein S1) SL1344_1923(outer membrane protein S1) Cluster3049 1 0 0 1 1 1 1 ROD_20421(putative membrane protein) b1963(inner membrane protein) BN373_30131(putative outer membrane protein N precursor) t0884(putative membrane protein) SL1344_1922(putative membrane protein) Cluster3050 1 1 1 1 1 0 0 ROD_19531(L-arabinose ABC transporter, substrate-binding protein) ENC_05860(L-arabinose-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1983(L-arabinose-binding periplasmic protein precursor,D-ribose transporter subunit RbsB,ABC-type sugar transport system, periplasmic component,rhamnose ABC transporter, rhamnose-binding protein,Periplasmic binding proteins and sugar binding domain of LacI family) b1901(L-arabinose transporter subunit) BN373_29821(L-arabinose ABC transporter, periplasmic L-arabinose-binding protein) Cluster3051 1 1 1 1 1 0 0 pseudoROD_19521(arabinose import ATP-binding protein AraG (pseudogene)) ENC_05870(ABC-type sugar transport system, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1984(Arabinose import ATP-binding protein AraG,L-arabinose transporter ATP-binding protein,Predicted periplasmic lipoprotein,D-xylose ABC transporter, ATP-binding protein,ABC transporter) b1900(fused L-arabinose transporter subunits of ABC superfamily: ATP-binding components) BN373_29811(L-arabinose ABC transporter, ATP-binding protein) Cluster3052 1 1 1 1 1 0 0 ROD_19501(L-arabinose ABC transporter, permease protein) ENC_05890(L-arabinose ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1985(Ribose transport system permease protein rbsC,L-arabinose transporter permease protein,Predicted ABC-type sugar transport system, permease component,Branched-chain amino acid transport system / permease component) b4460(fused L-arabinose transporter subunits of ABC superfamily: membrane components) BN373_29801(L-arabinose ABC transporter, permease protein) Cluster3053 1 0 0 1 1 1 1 ROD_18651(putative exported protein) b1826(regulatory peptide for PhoPQ, feedback inhibition) BN373_29261(putative lipoprotein) t1038(putative membrane protein) SL1344_1769(putative membrane protein) Cluster3054 1 0 0 1 1 1 1 ROD_18441(long-chain-fatty-acid--CoA ligase) b1805(acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase)) BN373_29051(long-chain-fatty-acid--CoA ligase) t1059(long-chain-fatty-acid--CoA ligase) SL1344_1747(long-chain-fatty-acid--CoA ligase) Cluster3055 1 0 1 1 1 0 1 ROD_18211(periplasmic trehalase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2681(Periplasmic trehalase precursor,trehalase,Trehalase) b1197(periplasmic trehalase) BN373_28861(trehalase) SL1344_1724(Periplasmic trehalase precursor) Cluster3056 1 1 1 1 1 0 0 ROD_07641(LysR-family transcriptional regulator) ENC_41890(transcriptional regulator, LysR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3230(Morphology and auto-aggregation control protein,DNA-binding transcriptional regulator CynR,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b0768(predicted DNA-binding transcriptional regulator) BN373_28591(transcriptional regulator, LysR family) Cluster3057 1 1 1 1 1 0 0 ROD_17951(cation transport protein) ENC_07680(Uncharacterized protein involved in cation transport) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2626(Uncharacterized protein involved in cation transport,ChaC-like protein) b1218(cation transport regulator) BN373_28211(cation transport protein) Cluster3058 1 0 1 1 1 0 1 ROD_17751(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2606(hypothetical protein,hypothetical protein,Predicted metal-binding protein related to the C-terminal domain of SecA,SWIM/SEC-C metal-binding motif protein, PBPRA1643 family,SEC-C motif) b1233(conserved protein, UPF0225 family) BN373_28011(SEC-C motif domain protein) SL1344_1686(Hypothetical UPF0225 protein) Cluster3059 1 0 1 1 2 0 0 ROD_15491(putative CoA-transferase alpha subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1486(Acetate CoA-transferase subunit alpha,acetyl-CoA:acetoacetyl-CoA transferase subunit alpha,Acyl CoA:acetate/3-ketoacid CoA transferase,3-oxoacid CoA-transferase, A subunit,Coenzyme A transferase) b2221(acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit) BN373_26411(3-oxoacid CoA-transferase, subunit A family),BN373_32471(acetyl-CoA:acetoacetyl-CoA transferase subunit alpha) Cluster3060 0 0 4 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.183(chromate transporter, chromate ion transporter (CHR) family,Chromate transporter),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.2(chromate transporter, chromate ion transporter (CHR) family,Chromate transporter),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.21(chromate transporter, chromate ion transporter (CHR) family,Chromate transporter),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.4(chromate transporter, chromate ion transporter (CHR) family,Chromate transporter) BN373_26321(chromate transporter, chromate ion transporter (CHR) family) Cluster3061 1 1 1 1 1 0 0 ROD_14131(major facilitator superfamily protein) ENC_13310(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2225(Inner membrane transport protein ydhP,MFS transport protein AraJ,Arabinose efflux permease,multidrug resistance protein,Major Facilitator Superfamily) b1657(predicted transporter) BN373_25771(transporter, major facilitator family) Cluster3062 0 1 1 1 1 0 1 ENC_11210(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3614(Transcriptional repressor frmR,regulator protein FrmR,Uncharacterised BCR, COG1937) b0357(regulator protein that represses frmRAB operon) BN373_25341(conserved hypothetical protein) SL1344_1558(conserved hypothetical protein) Cluster3063 1 1 0 0 1 1 1 ROD_16101(putative esterase) ENC_11150(Carboxylesterase type B) BN373_25271(para-nitrobenzyl esterase) t1532(putative esterase) SL1344_1553(putative esterase) Cluster3064 1 1 1 1 1 0 0 ROD_15751(flavin reductase-like protein) ENC_09700(Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2366(Flavoredoxin,Flavin reductase like domain) b1462(conserved protein) BN373_24691(flavin reductase domain protein) Cluster3065 1 0 0 0 2 1 1 ROD_04061(ABC transporter periplasmic iron-binding protein) BN373_24671(ABC transporter, periplasmic substrate-binding protein),BN373_47051(2-aminoethylphosphonate ABC transporter substrate-binding protein) t2434(probable periplasmic binding component of 2-aminoethylphosphonate transporter) SL1344_0423(probable periplasmic binding component of 2-aminoethylphosphonate transporter) Cluster3066 1 1 0 0 1 1 1 ROD_15671(putative transcriptional regulator, TetR family) ENC_09780(Uncharacterized protein conserved in bacteria) BN373_24591(transcriptional regulator, TetR family) t1486(putative regulatory protein) SL1344_1506(putative regulatory protein) Cluster3067 1 1 0 0 1 1 1 ROD_15661(methyl viologen resistance protein SmvA) ENC_09790(Arabinose efflux permease) BN373_24581(putative methyl viologen resistance protein SmvA) t1485(methyl viologen resistance protein SmvA) SL1344_1505(methyl viologen resistance protein SmvA) Cluster3068 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2351(Alcohol dehydrogenase, propanol-preferring,ethanol-active dehydrogenase/acetaldehyde-active reductase,Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase,NDMA-dependent alcohol dehydrogenase, Rxyl_3153 family,Alcohol dehydrogenase GroES-like domain) b1478(ethanol-active dehydrogenase/acetaldehyde-active reductase) BN373_24331(alcohol dehydrogenase) t1482(alcohol dehydrogenase) SL1344_1497(alcohol dehydrogenase) Cluster3069 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.185(hypothetical protein,putative Mg(2+) transport ATPase,MgtC family) b3508(predicted Mg(2+) transport ATPase, inner membrane protein) BN373_24001(magnesium transport protein MgtC) t3754(conserved hyopthetical protein) SL1344_3729(Mg(2+) transport ATPase protein C) Cluster3070 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3463(Allantoate amidohydrolase,allantoate amidohydrolase,Uncharacterized protein conserved in bacteria,allantoate amidohydrolase,Peptidase family M20/M25/M40) b0516(allantoate amidohydrolase) BN373_23361(N-carbamoyl-L-amino acid hydrolase) t2334(allantoate amidohydrolase) SL1344_0520(allantoate amidohydrolase) Cluster3071 1 1 1 1 1 0 0 ROD_13901(putative exported protein) ENC_13440(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2213(hypothetical protein,Uncharacterized protein conserved in bacteria) b1668(conserved protein with FAD/NAD(P)-binding domain) BN373_23311(conserved hypothetical protein) Cluster3072 1 1 0 0 1 1 1 ROD_27061(LacI-family transcriptional regulator) ENC_39100(transcriptional regulator, LacI family) BN373_23241(putative periplasmic binding protein/LacI transcriptional regulator) t0519(putative transcriptional regulator) SL1344_2314(putative transcriptional regulator) Cluster3073 1 1 1 1 1 0 0 ROD_34701(D-allulose-6-phosphate 3-epimerase) ENC_05190(D-allulose 6-phosphate 3-epimerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4380(D-allulose-6-phosphate 3-epimerase,allulose-6-phosphate 3-epimerase,Pentose-5-phosphate-3-epimerase,ribulose-phosph ate 3-epimerase,Ribulose-phosphate 3 epimerase family) b4085(allulose-6-phosphate 3-epimerase) BN373_23201(allulose-6-phosphate 3-epimerase) Cluster3074 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4101(Putative sgc region protein SgcQ,membrane complex biogenesis protein, BtpA family,BtpA family) b4303(KpLE2 phage-like element; predicted nucleoside triphosphatase) BN373_23031(BtpA family protein) t1524(conserved hypothetical protein) SL1344_1545(conserved hypothetical protein) Cluster3075 1 1 1 1 1 0 0 ROD_40431(putative transcriptional regulator) ENC_20080(transcriptional regulator, GntR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3270(hypothetical protein,DNA-binding transcriptional repressor MngR,Transcriptional regulators,phosphonate metabolism transcriptional regulator PhnF,UTRA domain) b0730(DNA-binding transcriptional dual regulator, fatty-acyl-binding) BN373_22651(transcriptional regulator, GntR family) Cluster3076 1 1 0 1 2 0 0 ROD_40451(6-phospho-alpha-glucosidase) ENC_03740(6-phospho-alpha-glucosidase) pseudob4556(unknown) BN373_22631(maltose-6'-phosphate glucosidase),BN373_47291(maltose-6'-phosphate glucosidase) Cluster3077 1 1 1 1 1 0 0 ROD_15351(putative lipoprotein) ENC_10230(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2345(Uncharacterized protein conserved in bacteria,Uncharacterised BCR, COG1649) b1491(liprotein, glycosyl hydrolase homolog) BN373_22491(conserved hypothetical protein) Cluster3078 2 0 0 0 1 1 1 ROD_13981(conserved hypothetical protein),ROD_22631(putative N-hydroxybenzoate hydroxylase) BN373_22431(FAD binding protein) t0680(putative n-hydroxybenzoate hydroxylase) SL1344_2152(putative n-hydroxybenzoate hydroxylase) Cluster3079 1 0 1 0 1 1 1 ROD_01301(putative transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3316(HTH-type transcriptional repressor glcR,DNA-binding transcriptional regulator AgaR,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,Bacterial regulatory proteins, deoR family) BN373_22071(transcriptional regulator, DeoR family) t0169(putative transcriptional regulator) SL1344_0165(putative transcriptional regulator) Cluster3080 1 0 1 0 1 1 1 ROD_01291(4-hydroxythreonine-4-phosphate dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3317(4-hydroxythreonine-4-phosphate dehydrogenase 2,4-hydroxythreonine-4-phosphate dehydrogenase 2,Uncharacterized protein conserved in bacteria,4-hydroxythreonine-4-phosphate dehydrogenase,Pyridoxal phosphate biosynthetic protein PdxA) BN373_22061(putative 4-hydroxythreonine-4-phosphate dehydrogenase) t0168(PdxA-like protein) SL1344_0164(4-hydroxythreonine-4-phosphate dehydrogenase) Cluster3081 1 0 1 0 1 1 1 ROD_01281(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3318(hypothetical protein,Uncharacterized protein conserved in bacteria,Protein of unknown function, DUF1537) BN373_22051(conserved hypothetical protein) t0167(conserved hypothetical protein) SL1344_0163(conserved hypothetical protein) Cluster3082 1 1 1 1 1 0 0 ROD_03981(lactose permease) ENC_36510(oligosaccharide:H+ symporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3628(Lactose-proton symport,galactoside permease,Uncharacterized protein conserved in bacteria,oligosaccharide:H+ symporter,LacY proton/sugar symporter) b0343(lactose permease) BN373_21761(lactose permease) Cluster3083 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1040(HTH-type transcriptional repressor glcR,DNA-binding transcriptional regulator AgaR,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,Bacterial regulatory proteins, deoR family) b2735(predicted transcriptional regulator, DeoR family) BN373_21691(transcriptional regulator, DeoR family) t2820(DeoR-family trancriptional regulator) SL1344_2898(DeoR-family trancriptional regulator) Cluster3084 1 0 1 1 1 0 1 ROD_12391(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1038(hypothetical protein,Uncharacterized protein conserved in bacteria,Protein of unknown function, DUF1537) b2737(conserved protein) BN373_21651(YgbK domain protein) SL1344_2896(conserved hypothetical protein) Cluster3085 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1036(hypothetical protein,hypothetical protein,Hydroxypyruvate isomerase,hydroxypyruvate isomerase,Xylose isomerase-like TIM barrel) b2739(conserved protein) BN373_21611(AP endonuclease, family 2) t2816(putative hydroxypyruvate isomerase) SL1344_2894(putative hydroxypyruvate isomerase) Cluster3086 1 1 0 0 3 0 0 ROD_18131(putative LuxR-family transcriptional regulator) ENC_13790(Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain) BN373_21521(putative 2-component transcriptional regulator),BN373_21571(putative LuxR family regulatory protein),BN373_31271(putative positive transcription regulator) Cluster3087 1 0 1 1 1 0 1 ROD_16381(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1892(hypothetical protein,hypothetical protein,Uncharacterised ACR, COG2135) b1931(predicted protein) BN373_21511(gifsy-2 prophage yedk) SL1344_0993(predicted bacteriophage protein) Cluster3088 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2299(lipoprotein,Uncharacterised protein family (UPF0257)) b1585(lipoprotein, UPF0257 family) BN373_21391(putative lipoprotein) t1422(conserved hypothetical protein) SL1344_1431(conserved hypothetical protein) Cluster3089 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2293(DMSO reductase anchor subunit,DMSO reductase anchor subunit (DmsC)) b1590(oxidoreductase, membrane subunit) BN373_21351(putative anaerobic dimethyl sulfoxide reductase, C subunit) t1417(putative dimethyl sulfoxide reductase subunit) SL1344_1426(putative dimethyl sulphoxide reductase subunit) Cluster3090 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2291(Voltage-gated ClC-type chloride channel ClcB,putative voltage-gated ClC-type chloride channel ClcB,Voltage gated chloride channel) b1592(chloride channel, voltage-gated) BN373_21331(chloride transporter, chloride channel (ClC) family) t1411(putative voltage gated chloride channel protein) SL1344_1420(Voltage-gated ClC-type chloride channel clcB. Putative chloride channel protein clcB-like) Cluster3091 1 1 1 1 1 0 0 ROD_36081(putative tartrate carrier protein) ENC_41950(anion transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.630(Tartrate transporter,transporter, divalent anion:Na+ symporter (DASS) family,Sodium:sulfate symporter transmembrane region) b3063(L-tartrate/succinate antiporte) BN373_21031(putative tartrate carrier) Cluster3092 1 1 1 1 1 0 0 ROD_14481(maltose and glucose-specific PTS system, EIICB component) ENC_12890(PTS system IIB component, Glc family (TC 4.A.1)/PTS system IIC component, Glc family (TC 4.A.1)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2260(EIICBA-Glc,bifunctional PTS system maltose and glucose-specific transporter subunits IICB,PTS system, maltose and glucose-specific IIBC component,Phosphotransferase system, EIIC) b1621(fused maltose and glucose-specific PTS enzymes: IIB component, IIC component) BN373_20681(PTS system, maltose and glucose-specific IIBC component) Cluster3093 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2722(hypothetical protein,Phage envelope protein,Protein of unknown function (DUF1398)) b1161(predicted protein) BN373_20601(conserved hypothetical protein) t1022(conserved hypothetical protein) SL1344_1785(conserved hypothetical protein) Cluster3094 1 1 1 1 1 0 0 ROD_16231(aldehyde dehydrogenase A) ENC_11350(lactaldehyde dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2401(Lactaldehyde dehydrogenase,aldehyde dehydrogenase A,Delta 1-pyrroline-5-carboxylate dehydrogenase,succinate-semialdehyde dehydrogenase,Aldehyde dehydrogenase family) b1415(aldehyde dehydrogenase A, NAD-linked) BN373_20571(aldehyde dehydrogenase A) Cluster3095 1 1 0 0 1 1 1 ROD_16291(conserved hypothetical protein) ENC_09230(Uncharacterized conserved protein) BN373_20371(conserved hypothetical protein) t1546(hypothetical protein) SL1344_1573(hypothetical protein) Cluster3096 1 1 0 1 2 0 0 ROD_16661(putative thiolase) ENC_11610(beta-ketoadipyl CoA thiolase) b1397(3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase) BN373_20331(beta-ketoadipyl CoA thiolase PaaJ),BN373_20971(beta-ketoadipyl CoA thiolase) Cluster3097 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2414(Putative hemolysin,Domain of unknown function (DUF333)) b4529(predicted lipoprotein, DUF333 family) BN373_20011(putative lipoprotein) t1552(conserved hypothetical protein) SL1344_1579(conserved hypothetical protein) Cluster3098 1 0 1 1 1 0 1 ROD_16591(ATP-independent RNA helicase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2421(ATP-independent RNA helicase dbpA,ATP-dependent RNA helicase DbpA,Predicted transporter component,DEXH box helicase, DNA ligase-associated,DEAD/DEAH box helicase) b1343(ATP-dependent RNA helicase, specific for 23S rRNA) BN373_19951(ATP-independent RNA helicase DbpA) SL1344_1586(ATP-independent RNA helicase (DbpA)) Cluster3099 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4201(mycofactocin system transcriptional regulator,Bacterial regulatory proteins, tetR family) b4251(predicted transcriptional regulator) BN373_19711(transcriptional regulator, TetR family) t1578(putative transcriptional regulator) SL1344_1604(putative transcriptional regulator) Cluster3100 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4202(3-oxoacyl-[acyl-carrier-protein] reductase FabG1,oxidoreductase,Uncharacterized conserved protein,3-oxoacyl-[acyl-carrier-protein] reductase,short chain dehydrogenase) b4249(predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain) BN373_19701(oxidoreductase) t1579(putative oxidoreductase) SL1344_1605(putative oxidoreductase) Cluster3101 1 2 1 0 1 0 0 ROD_38091(Hcp family T6SS protein CtsH1) ENC_08950(type VI secretion system effector, Hcp1 family),ENC_31190(type VI secretion system effector, Hcp1 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.952(Secreted protein hcp,Hemolysin-coregulated protein (uncharacterized),type VI secretion system effector, Hcp1 family,Protein of unknown function (DUF796)) BN373_19541(type VI secretion system effector, Hcp1 family) Cluster3102 1 1 1 0 2 0 0 ROD_27871(T6SS protein Cts1O) ENC_08940(Outer membrane protein and related peptidoglycan-associated (lipo)proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.953(Inner membrane lipoprotein YiaD precursor,flagellar motor protein MotB,Outer membrane protein and related peptidoglycan-associated (lipo)proteins,type VI secretion system OmpA/MotB family protein,OmpA family) BN373_19531(OmpA domain protein),BN373_28521(OmpA domain protein) Cluster3103 1 1 1 0 1 0 1 ROD_27751(T6SS protein Cts1B) ENC_08910(type VI secretion protein, EvpB/VC_A0108 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.956(Uncharacterized protein conserved in bacteria,type VI secretion protein, EvpB/VC_A0108 family,Protein of unknown function (DUF877)) BN373_19501(type VI secretion protein, EvpB/VC_A0108 family) SL1344_0268(conserved hypothetical protein (SPI-6 associated)) Cluster3104 1 1 1 1 1 0 0 ROD_17271(putative membrane protein) ENC_08350(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2491(hypothetical protein) b4522(hypothetical protein) BN373_18971(conserved hypothetical protein) Cluster3105 1 1 1 1 1 0 0 ROD_13061(putative membrane protein) ENC_14490(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2130(TVP38/TMEM64 family inner membrane protein ydjZ,SNARE associated Golgi protein) b1750(inner membrane protein, TVP38/TMEM64 family) BN373_18421(putative membrane protein) Cluster3106 1 1 1 1 1 0 0 ROD_13001(putative decarboxylase) ENC_14550(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2127(Arsenate reductase and related proteins, glutaredoxin family,Carboxymuconolactone decarboxylase family) b1753(conserved protein) BN373_18401(carboxymuconolactone decarboxylase family protein) Cluster3107 1 1 1 1 1 0 0 ROD_13051(putative exported protein) ENC_14500(ABC-type uncharacterized transport system, periplasmic component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2126(hypothetical protein,hypothetical protein,ABC-type uncharacterized transport system, periplasmic component) b1754(conserved protein) BN373_18391(conserved hypothetical protein) Cluster3108 1 1 1 1 1 0 0 ROD_13041(putative membrane protein) ENC_14510(ABC-type uncharacterized transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2125(Inner membrane ABC transporter permease protein ynjC,putative 2-aminoethylphosphonate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component) b1755(Predicted inner membrane ABC transporter permease, function unknown) BN373_18381(ABC transporter, permease protein) Cluster3109 1 1 1 1 1 0 0 ROD_13031(ABC transporter, ATP-binding protein) ENC_14520(ABC-type uncharacterized transport system, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2124(Fe(3+) ions import ATP-binding protein FbpC 2,thiamine transporter ATP-binding subunit,ABC-type spermidine/putrescine transport systems, ATPase components,putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein,ABC transporter) b1756(predicted transporter subunit: ATP-binding component of ABC superfamily) BN373_18371(ABC transporter, ATP-binding protein) Cluster3110 1 1 1 1 1 0 0 ROD_13021(putative thiosulfate sulfurtransferase) ENC_14530(Rhodanese-related sulfurtransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2123(Thiosulfate sulfurtransferase YnjE precursor,3-mercaptopyruvate sulfurtransferase,Rhodanese-like domain) b1757(predicted thiosulfate sulfur transferase) BN373_18361(thiosulfate sulfurtransferase homolog) Cluster3111 1 1 1 1 1 0 0 ROD_13011(putative CDP-alcohol phosphatidyltransferase) ENC_14540(Phosphatidylglycerophosphate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2122(Inner membrane protein YnjF,CDP-alcohol phosphatidyltransferase) b1758(inner membrane protein, phosphatidylglycerophosphate synthase homolog) BN373_18351(CDP-alcohol phosphatidyltransferase family protein) Cluster3112 0 1 0 0 1 1 2 ENC_11910(DinI-like family.) BN373_18041(putative virulence protein MsgA) t1113(putative virulence protein) SL1344_1180(putative virulence protein (MsgA)),SL1344_2207(putative SsrB-regulated factor) Cluster3113 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2090(Inner membrane transport protein YeaN,putative cyanate transporter,cyanate transporter,Major Facilitator Superfamily) b1791(predicted transporter) BN373_17991(cyanate transporter, CynX family) t1158(putative membrane protein) SL1344_1214(putative membrane protein) Cluster3114 1 1 0 0 1 1 1 ROD_17481(putative catalase) ENC_31020(Mn-containing catalase) BN373_17771(putative manganese containing catalase) t1643(conserved hypothetical protein) SL1344_1662(conserved hypothetical protein) Cluster3115 0 1 0 1 1 1 1 ENC_30990(Stress-induced bacterial acidophilic repeat motif.) b1259(predicted protein) BN373_17741(hypothetical protein) t1434(conserved hypothetical protein) SL1344_1443(conserved hypothetical protein) Cluster3116 0 0 1 1 1 0 2 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2779(Site-specific recombinase XerD,Bacteriophage lambda integrase, N-terminal domain) b1140(e14 prophage; predicted integrase) BN373_17621(site-specific recombinase, phage integrase family) SL1344_1806(Integrase),pseudoSL1344_1791(bacteriophage integrase (pseudogene)) Cluster3117 1 1 1 1 1 0 0 ROD_10731(putative peroxidase) ENC_16110(Tat-translocated enzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2891(Deferrochelatase/peroxidase EfeB precursor,Tat-translocated enzyme,Dyp-type peroxidase family) b1019(deferrrochelatase, periplasmic) BN373_16621(Tat-translocated enzyme) Cluster3118 1 1 1 1 1 0 0 ROD_10721(putative exported protein) ENC_16120(Predicted periplasmic lipoprotein involved in iron transport) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2892(Iron uptake system component EfeO precursor,inactive ferrous ion transporter periplasmic protein EfeO,Imelysin) b1018(inactive ferrous ion transporter EfeUOB) BN373_16611(conserved hypothetical protein) Cluster3119 1 1 0 0 1 1 1 ROD_10671(putative exported protein) ENC_16210(Uncharacterized protein conserved in bacteria) BN373_16551(conserved hypothetical protein) t1798(putative secreted protein) SL1344_1061(putative secreted protein) Cluster3120 0 1 0 0 4 0 0 ENC_16440(hypothetical protein) BN373_16391(putative transcriptional regulator),BN373_23491(putative transcriptional regulator),BN373_25381(putative transcriptional regulator),BN373_26361(putative transcriptional regulator) Cluster3121 1 1 1 1 1 0 0 ROD_10061(FMN reductase (sulfate starvation-induced protein) ENC_16860(FMN reductase, SsuE family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2956(FMN reductase (NADPH),NAD(P)H-dependent FMN reductase,Predicted flavoprotein,FMN reductase,NADPH-dependent FMN reductase) b0937(NAD(P)H-dependent FMN reductase) BN373_15851(NADPH-dependent FMN reductase) Cluster3122 1 1 1 1 1 0 0 ROD_10051(putative aliphatic sulfonates ABC transporter, substrate-binding protein) ENC_16870(ABC transporter, substrate-binding protein, aliphatic sulfonates family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2957(Putative aliphatic sulfonates-binding protein precursor,alkanesulfonate transporter substrate-binding subunit,ABC-type taurine transport system, periplasmic component,ABC transporter, substrate-binding protein, aliphatic sulfonates family,NMT1/THI5 like) b0936(putative aliphatic sulfonate binding protein) BN373_15841(aliphatic sulfonates ABC transporter, periplasmic sulfonate-binding protein) Cluster3123 1 1 1 1 1 0 0 ROD_10031(putative aliphatic sulfonates ABC transporter, permease protein) ENC_16900(ABC-type nitrate/sulfonate/bicarbonate transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2959(Putative aliphatic sulfonates transport permease protein ssuC,alkanesulfonate transporter permease subunit,ABC-type anion transport system, duplicated permease component,nitrate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component) b0934(putative alkanesulfonate transporter subunit) BN373_15821(aliphatic sulfonates ABC transporter, permease protein) Cluster3124 1 1 1 1 1 0 0 ROD_10021(putative aliphatic sulfonates ABC transporter, ATP-binding protein) ENC_16910(ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2960(Aliphatic sulfonates import ATP-binding protein SsuB,aliphatic sulfonates transport ATP-binding subunit,ABC-type spermidine/putrescine transport systems, ATPase components,putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein,ABC transporter) b0933(alkanesulfonate transporter subunit) BN373_15811(aliphatic sulfonates ABC transporter, ATP-binding protein) Cluster3125 1 0 1 1 1 0 1 ROD_34021(putative diaminopropionate ammonia-lyase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.884(Diaminopropionate ammonia-lyase,diaminopropionate ammonia-lyase,Threonine dehydratase,diaminopropionate ammonia-lyase family,Pyridoxal-phosphate dependent enzyme) b2871(2,3-diaminopropionate ammonia-lyase) BN373_15751(diaminopropionate ammonia-lyase) SL1344_0939(diaminopropionate ammonia-lyase (ec 4.3.1.15) (diaminopropionatase) (alpha,beta-diaminopropionate ammonia-lyase)) Cluster3126 1 1 1 1 1 0 0 ROD_08851(aquaporin Z) ENC_18110(MIP family channel proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3123(Bacterial nodulin-like intrinsic protein,aquaporin Z,MIP family channel proteins,Major intrinsic protein) b0875(aquaporin Z) BN373_15251(aquaporin Z) Cluster3127 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3148(hypothetical protein,Protein of unknown function (DUF1418)) b0850(conserved protein, DUF1418 family) BN373_14961(putative membrane protein) t2023(putative membrane protein) SL1344_0849(putative membrane protein) Cluster3128 0 0 0 0 1 3 1 BN373_14881(putative bacteriophage protein) t2663(putative bacteriophage protein),t3441(hypothetical protein),t4298(hypothetical protein) SL1344_2669(predicted bacteriophage protein) Cluster3129 1 0 1 1 1 1 0 ROD_09041(putative phage tail fibre protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3035(Phage tail fibre repeat) pseudob1157(unknown) BN373_14821(putative prophage endo-N-neuraminidase) t1351(bacteriophage tail fiber protein) Cluster3130 1 0 1 0 1 1 1 ROD_36721(putative phage tail protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3080(Phage Tail Protein X) BN373_14701(phage Tail Protein X) t4316(putative phage tail protein) SL1344_2688(putative bacteriophage tail protein) Cluster3131 1 0 1 0 1 1 1 ROD_20061(putative phage integrase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3051(Tyrosine recombinase XerD,site-specific tyrosine recombinase XerC,Site-specific recombinase XerD,tyrosine recombinase XerD,Phage integrase family) BN373_14491(integrase family protein) t3400(probable bacteriophage integrase) SL1344_2631(bacteriophage integrase) Cluster3132 1 2 1 0 1 0 0 ROD_32791(putative transcriptional regulator) ENC_18930(Transcriptional regulators),ENC_43280(Transcriptional regulators) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.16(HTH-type transcriptional repressor CytR,DNA-binding transcriptional regulator CytR,ABC-type sugar transport system, periplasmic component,catabolite control protein A,Periplasmic binding proteins and sugar binding domain of LacI family) BN373_14201(sugar-binding domain protein, LacI family) Cluster3133 1 0 1 1 1 0 1 ROD_08051(putative glycosyl transferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3198(Anthranilate phosphoribosyltransferase 2,glycosyl transferase family protein,anthranilate phosphoribosyltransferase,Glycosyl transferase family, helical bundle domain) b0800(predicted family 3 glycosyltransferase) BN373_13951(glycosyl transferase family protein) SL1344_0798(putative glycosyltransferase) Cluster3134 1 0 0 1 1 1 1 ROD_07821(molybdenum cofactor biosynthesis protein A) b0781(molybdopterin biosynthesis protein A) BN373_13731(molybdenum cofactor biosynthesis protein A) t2085(molybdenum cofactor biosynthesis protein A) SL1344_0778(molybdenum cofactor biosynthesis protein A) Cluster3135 1 1 0 0 1 1 1 ROD_07731(histidine ammonia-lyase) ENC_19660(histidine ammonia-lyase) BN373_13581(histidine ammonia-lyase) t2096(histidine ammonia-lyase) SL1344_0768(histidine ammonia-lyase) Cluster3136 1 1 0 0 1 1 1 ROD_07721(urocanate hydratase) ENC_19670(urocanate hydratase) BN373_13571(urocanate hydratase) t2097(urocanate hydratase) SL1344_0767(urocanate hydratase) Cluster3137 1 1 0 0 1 1 1 ROD_07711(histidine utilization repressor) ENC_19680(transcriptional regulator, GntR family) BN373_13561(histidine utilization repressor) t2098(histidine utilization repressor) SL1344_0766(histidine utilization repressor) Cluster3138 1 1 0 0 1 1 1 ROD_07701(formiminoglutamase) ENC_19690(formiminoglutamase) BN373_13551(formimidoylglutamase) t2099(formiminoglutamase) SL1344_0765(formiminoglutamase) Cluster3139 1 1 0 0 1 1 1 ROD_07691(imidazolonepropionase) ENC_19700(imidazolonepropionase) BN373_13541(imidazolonepropionase) t2100(imidazolonepropionase) SL1344_0764(imidazolonepropionase) Cluster3140 1 1 1 1 1 0 0 ROD_15361(MerR-family transcriptional regulator) ENC_13720(Predicted transcriptional regulators) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2721(HTH-type transcriptional repressor YcgE,transcriptional regulator MirA,Hg(II)-responsive transcriptional regulator,MerR family regulatory protein) b1162(repressor of blue light-responsive genes) BN373_13421(transcriptional regulator MlrA) Cluster3141 1 1 1 1 1 0 0 ROD_15371(putative signal transduction protein) ENC_13730(FOG: EAL domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2720(Blue light- and temperature-regulated antirepressor YcgF,putative diguanylate cyclase,Predicted signal transduction protein containing sensor and EAL domains,EAL domain) b1163(anti-repressor for YcgE, blue light-responsive; FAD-binding; has c-di-GMP phosphodiesterase-like EAL domain, but does not degrade c-di-GMP) BN373_13411(BLUF domain/cyclic diguanylate phosphodiesterase (EAL) domain protein) Cluster3142 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3313(hypothetical protein) b0682(novel lipoprotein induced by chitosugars) BN373_12761(putative lipoprotein) t2187(putative lipoprotein) SL1344_0670(putative lipoprotein) Cluster3143 1 0 1 1 1 0 1 ROD_06401(putative carbon-nitrogen hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3373(N-carbamoyl-D-amino acid hydrolase,C-N hydrolase family amidase,NAD synthase,N-carbamoylputrescine amidase,Carbon-nitrogen hydrolase) pseudob4581(unknown) BN373_12381(hydrolase, carbon-nitrogen family) SL1344_0619(possible hydrolase) Cluster3144 1 1 1 0 2 0 0 ROD_22161(ABC transporter ATP-binding protein) ENC_21650(ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4393(Glutathione import ATP-binding protein GsiA,dipeptide transporter ATP-binding subunit,ABC-type oligopeptide transport system, ATPase component,nickel import ATP-binding protein NikE,ABC transporter) BN373_11541(ABC transporter, ATP-binding protein),BN373_31371(ABC transporter, ATP-binding protein) Cluster3145 1 2 0 0 2 0 0 ROD_34351(putative cation-transporting P-type ATPase) ENC_21840(ATPase, P-type (transporting), HAD superfamily, subfamily IC),ENC_41700(ATPase, P-type (transporting), HAD superfamily, subfamily IC) BN373_11311(cation transporting ATPase, E1-E2 family),BN373_13521(cation transporting ATPase, E1-E2 family) Cluster3146 1 1 0 0 1 1 1 ROD_05711(transcriptional activator RamA) ENC_21880(transcriptional regulator, AraC family) BN373_11281(transcriptional activator RamA) t2287(transcriptional activator RamA) SL1344_0569(transcriptional activator RamA) Cluster3147 0 0 0 1 2 1 1 b1385(phenylacetaldehyde dehydrogenase) BN373_11041(putative phenylacetaldehyde dehydrogenase),BN373_20091(phenylacetaldehyde dehydrogenase) t3051(possible aldehyde dehydrogenase) SL1344_3103(possible aldehyde dehydrogenase) Cluster3148 1 0 1 0 1 1 1 ROD_07451(ABC transporter permease (FecCD family)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1732(Probable ABC transporter permease protein HI_1471,iron-hydroxamate transporter permease subunit,ABC-type Fe3+-siderophore transport system, permease component,proposed F420-0 ABC transporter, permease protein,FecCD transport family) BN373_10831(ABC transporter, iron chelate uptake transporter (FeCT) family, permease protein) t2117(ABC transporter permease (FecCD_family)) SL1344_0747(ABC transporter permease (FecCD_family)) Cluster3149 1 0 1 0 1 1 1 ROD_07461(ABC transporter ATP-binding protein,abc transporter atp-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1733(Probable siderophore transport system ATP-binding protein YusV,hemin importer ATP-binding subunit,ABC-type enterochelin transport system, ATPase component,proposed F420-0 ABC transporter, ATP-binding protein,ABC transporter) BN373_10821(ABC transporter, iron chelate uptake transporter (FeCT) family, ATP-binding protein) t2116(ABC transporter ATP-binding protein) SL1344_0748(ABC transporter ATP-binding protein) Cluster3150 1 0 1 2 1 0 0 ROD_42241(HlyD-family secretion protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.90(Inner membrane protein yibH,multidrug resistance protein MdtN,efflux pump membrane protein,HlyD family secretion protein) b3586(membrane fusion protein (MFP) component of efflux pump, signal anchor),b3597(predicted protein) BN373_10811(auxiliary transport protein, membrane fusion protein (MFP) family) Cluster3151 1 0 1 2 1 0 0 ROD_42231(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.89(Inner membrane protein yiaW,Protein of unknown function (DUF3302)) b3587(inner membrane protein, DUF3302 family),b3598(inner membrane protein, DUF3302 family) BN373_10801(conserved hypothetical protein) Cluster3152 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4326(Arginine/agmatine antiporter,lysine/cadaverine antiporter,Amino acid transporters,transporter, basic amino acid/polyamine antiporter (APA) family,Amino acid permease) b4132(predicted lysine/cadaverine transporter) BN373_10631(putative cadaverine/lysine antiporter) t0298(probable cadaverine/lysine antiporter) SL1344_2520(probable cadaverine/lysine antiporter) Cluster3153 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4325(Transcriptional activator CadC,DNA-binding transcriptional activator CadC,phosphate regulon transcriptional regulatory protein PhoB,Transcriptional regulatory protein, C terminal) b4133(DNA-binding transcriptional activator) BN373_10621(transcriptional activator CadC) t0299(transcriptional activator CadC) SL1344_2519(transcriptional activator cadC) Cluster3154 1 1 0 0 1 1 1 ROD_12311(putative exported protein) ENC_11850(Protein of unknown function (DUF1471).) BN373_10611(conserved hypothetical protein) t0083(probable secreted protein) SL1344_0083(probable secreted protein) Cluster3155 2 0 0 0 1 1 1 ROD_03671(putative major fimbrial subunit),pseudoROD_29351(putative fimbrial subunit (pseudogene)) BN373_10551(fimbrial protein) t2521(probable fimbrial protein) SL1344_0335(probable fimbrial protein) Cluster3156 1 0 2 0 1 0 1 ROD_26131(putative phage antiterminator protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1945(Phage antitermination protein Q),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2758(Phage antitermination protein Q) BN373_10131(phage antitermination protein Q) SL1344_2579(putative antitermination protein) Cluster3157 0 0 1 1 1 0 2 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2759(hypothetical protein) b4509(expressed protein, DLP12 prophage) BN373_10121(conserved hypothetical protein) SL1344_0960(predicted bacteriophage protein),SL1344_2580(putative bacteriophage protein) Cluster3158 0 0 1 0 1 1 2 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1943(Protein of unknown function (DUF1367)) BN373_10081(conserved hypothetical protein) t1906(putative bacteriophage protein) SL1344_0958(Gifsy-2 bacteriophage protein),SL1344_2582(predicted bacteriophage protein) Cluster3159 0 1 1 1 1 1 0 ENC_24130(Phage integrase family.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3447(Phage integrase family) b0537(DLP12 prophage; predicted integrase) BN373_09741(site-specific recombinase, phage integrase family,site-specific recombinase, phage integrase family) t4252(shufflon-specific DNA recombinase) Cluster3160 1 1 0 0 1 1 1 ROD_05521(outer membrane protein) ENC_22310(Outer membrane protein (porin)) BN373_09641(conserved hypothetical protein) t2351(outer membrane protein) SL1344_0502(outer membrane protein) Cluster3161 1 0 0 1 1 1 1 ROD_05281(DNA polymerase III subunits gamma and tau) b0470(DNA polymerase III/DNA elongation factor III, tau and gamma subunits) BN373_09401(DNA polymerase III, tau subunit) t2376(DNA polymerase III subunits gamma and tau) SL1344_0477(DNA polymerase III subunits gamma and tau) Cluster3162 1 0 1 1 1 0 1 ROD_05251(primosomal replication protein N) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3514(Primosomal replication protein N'',primosomal replication protein N'',Primosomal replication protein N'',Primosomal replication protein priB and priC) b0467(primosomal replication protein N'') BN373_09371(primosomal replication protein N'') SL1344_0474(primosomal replication protein N) Cluster3163 1 1 0 0 1 1 1 ROD_05021(putative lyase) ENC_22970(Cysteine synthase) BN373_08981(pyridoxal-phosphate dependent enzyme) t2401(putative lyase) SL1344_0452(putative lyase) Cluster3164 1 1 0 0 1 1 1 ROD_04591(putative DeoR-family transcriptional regulator) ENC_23490(Predicted transcriptional regulator) BN373_08511(helix-turn-helix domain protein) t2453(putative DeoR-family transcriptional regulator) SL1344_0405(putative deoR-family transcriptional regulator) Cluster3165 1 1 0 0 1 1 1 ROD_04581(conserved hypothetical protein) ENC_23500(Predicted enzyme related to lactoylglutathione lyase) BN373_08501(glyoxalase family protein) t2454(conserved hypothetical protein) SL1344_0404(conserved hypothetical protein) Cluster3166 1 1 0 0 1 1 1 ROD_04511(probable peroxidase) ENC_23570(Peroxiredoxin) BN373_08431(antioxidant, AhpC/TSA family) t2461(probable peroxidase) SL1344_0397(probable peroxidase) Cluster3167 1 1 0 0 1 1 1 ROD_04251(putative efflux pump) ENC_23790(Arabinose efflux permease) BN373_08131(MdtG family protein) t2482(possible efflux pump) SL1344_0377(possible efflux pump) Cluster3168 1 1 1 1 1 0 0 ROD_04131(alpha-ketoglutarate-dependent taurine dioxygenase) ENC_23930(Probable taurine catabolism dioxygenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3610(Alpha-ketoglutarate-dependent taurine dioxygenase,taurine dioxygenase,Taurine catabolism dioxygenase TauD, TfdA family) b0368(taurine dioxygenase, 2-oxoglutarate-dependent) BN373_08021(taurine dioxygenase) Cluster3169 1 1 1 1 1 0 0 ROD_04111(taurine ABC transporter, ATP-binding protein) ENC_23960(ABC-type taurine transport system, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3612(Bicarbonate transport ATP-binding protein CmpD,taurine transporter ATP-binding subunit,ABC-type spermidine/putrescine transport systems, ATPase components,nitrate ABC transporter, ATP-binding proteins C and D,ABC transporter) b0366(taurine transporter subunit) BN373_08001(taurine ABC transporter, ATP-binding protein) Cluster3170 1 1 1 1 1 0 0 ROD_04101(taurine ABC transporter, substrate-binding protein (sulfate starvation induced protein)) ENC_23970(taurine ABC transporter, periplasmic binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3613(Sulfate starvation-induced protein 1,taurine transporter substrate binding subunit,ABC-type taurine transport system, periplasmic component,taurine ABC transporter, periplasmic binding protein,Substrate binding domain of ABC-type glycine betaine transport system) b0365(taurine transporter subunit) BN373_07991(taurine ABC transporter, periplasmic taurine-binding protein) Cluster3171 1 1 1 1 1 0 0 ROD_29241(putative fimbrial protein) ENC_03190(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3684(hypothetical protein) b0289(conserved protein) BN373_07831(conserved hypothetical protein) Cluster3172 1 1 1 1 1 0 0 ROD_29231(putative fimbrial protein) ENC_03200(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3683(hypothetical protein) b0290(predicted receptor) BN373_07821(conserved hypothetical protein) Cluster3173 1 1 1 1 1 0 0 ROD_29221(putative fimbrial usher protein) ENC_03210(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3682(fimbrial outer membrane usher protein TcfC) b0291(predicted aromatic compound dioxygenase) BN373_07811(conserved hypothetical protein) Cluster3174 1 1 1 1 1 0 0 ROD_29211(putative fimbrial protein) ENC_03220(Gram-negative pili assembly chaperone, N-terminal domain.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3681(hypothetical protein,putative fimbrial protein TcfA) b0292(predicted protein) BN373_07801(conserved hypothetical protein) Cluster3175 1 1 1 1 1 0 0 ROD_29201(putative fimbrial protein) ENC_03230(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3680(Meningitis associated and temperature regulated protein B) b0293(cryptic Mat fimbrillin gene) BN373_07791(fimbrillin MatB) Cluster3176 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1120(hypothetical protein,carbon starvation induced protein,CsiD) b2659(carbon starvation induced gene) BN373_07421(protein CsiD) t2684(gab protein homolog) SL1344_2773(Protein csiD) Cluster3177 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1119(L-2-hydroxyglutarate oxidase LhgO,hydroxyglutarate oxidase,Uncharacterized protein with conserved CXXC pairs,glycine oxidase ThiO,FAD dependent oxidoreductase) b2660(L-2-hydroxyglutarate oxidase) BN373_07411(FAD-dependent oxidoreductase) t2685(putative GAB DTP gene cluster repressor) SL1344_2774(putative GAB DTP gene cluster repressor) Cluster3178 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1117(4-aminobutyrate aminotransferase GabT,4-aminobutyrate aminotransferase,4-aminobutyrate aminotransferase and related aminotransferases,4-aminobutyrate transaminase,Aminotransferase class-III) b2662(4-aminobutyrate aminotransferase, PLP-dependent) BN373_07391(4-aminobutyrate transaminase) t2687(4-aminobutyrate aminotransferase) SL1344_2776(4-aminobutyrate aminotransferase) Cluster3179 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1115(Carbon starvation induced regulator,DNA-binding transcriptional regulator CsiR,Transcriptional regulators,phosphonate utilization associated transcriptional regulator,FCD domain) b2664(DNA-binding transcriptional repressor of csiD) BN373_07371(gab operon transcriptional repressor CsiR) t2689(putative transcriptional regulator) SL1344_2778(putative transcriptional regulator) Cluster3180 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3707(putative acyltransferase) b0234(predicted acyltransferase with acyl-CoA N-acyltransferase domain) BN373_07321(acetyltransferase, GNAT family) t3866(putative acetyltransferase) SL1344_3619(putative acetyltransferase) Cluster3181 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1161(Cysteine/O-acetylserine efflux protein,cysteine/O-acetylserine exporter,homoserine/Threonine efflux protein,LysE type translocator) b2578(cysteine and O-acetylserine exporter) BN373_07171(cysteine/O-acetylserine exporter) t0265(putative membrane protein) SL1344_2609(putative membrane protein) Cluster3182 1 0 2 1 1 0 0 ROD_44961(putative T2SS protein E) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.370(Type II traffic warden ATPase,hypothetical protein,Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB,type II secretion system protein E,Type II/IV secretion system protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.745(Type II traffic warden ATPase,hypothetical protein,Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB,type II secretion system protein E,Type II/IV secretion system protein) b3326(general secretory pathway component, cryptic) BN373_06491(pullulanase secretion protein PulE) Cluster3183 1 0 2 1 1 0 0 ROD_44951(putative T2SS protein F) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.369(hypothetical protein,type IV pilin biogenesis protein,type II secretion system protein F,Bacterial type II secretion system protein F domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.746(Cholera toxin secretion protein epsF,type IV pilin biogenesis protein,type II secretion system protein F,Bacterial type II secretion system protein F domain) b3327(general secretory pathway component, cryptic) BN373_06481(pullulanase secretion protein PulF) Cluster3184 0 1 2 1 1 0 0 ENC_18280(general secretion pathway protein I) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.366(type II secretion system protein I,Bacterial type II secretion system protein I/J),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.749(Type II secretory pathway, component PulJ,type II secretion system protein I,Bacterial type II secretion system protein I/J) b3330(general secretory pathway component, cryptic) BN373_06451(pullulanase secretion protein PulI) Cluster3185 1 1 1 1 1 0 0 ROD_44891(putative T2SS protein L) ENC_18250(general secretion pathway protein L) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.363(Cholera toxin secretion protein epsL,Type II secretory pathway, component PulL,type II secretion system protein L,GspL cytoplasmic actin-ATPase-like region) b3333(general secretory pathway component, cryptic) BN373_06421(pullulanase secretion protein PulL) Cluster3186 1 1 1 1 1 0 0 ROD_44871(putative T2SS leader peptidase GspO) ENC_18230(type 4 prepilin peptidase 1 . Aspartic peptidase. MEROPS family A24A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.741(Leader peptidase pppA,Flp pilus assembly protein, protease CpaA,Bacterial Peptidase A24 N-terminal domain) b2972(bifunctional prepilin leader peptidase/ methylase) BN373_06391(pullulanase secretion protein PulO) Cluster3187 1 1 0 0 1 1 1 ROD_01231(putative exported protein) ENC_46310(Protein of unknown function (DUF2950).) BN373_06121(putative secreted protein) t0162(probable secreted protein) SL1344_0156(probable secreted protein) Cluster3188 1 1 0 0 1 1 1 ROD_01171(putative symporter) ENC_46240(sugar (Glycoside-Pentoside-Hexuronide) transporter) BN373_06051(sugar transporter, glycoside-pentoside-hexuronide (GPH):cation symporter family) t0155(putative symporter) SL1344_0149(putative symporter) Cluster3189 1 1 0 0 1 1 1 ROD_01161(putatuve glycosysl hydrolase) ENC_46230(Predicted beta-xylosidase) BN373_06041(alpha-N-arabinofuranosidase) t0154(putatuve glycosysl hydrolase) SL1344_0148(putatuve glycosysl hydrolase) Cluster3190 1 1 0 0 1 1 1 ROD_00501(putative lipoprotein) ENC_45590(Bacterial protein of unknown function (DUF903).) BN373_05291(putative lipoprotein) t0081(putative lipoprotein) SL1344_0081(putative lipoprotein) Cluster3191 0 0 0 0 1 2 2 BN373_05171(oxaloacetate decarboxylase gamma subunit) t0058(oxaloacetate decarboxylase gamma chain),t3268(oxaloacetate decarboxylase gamma chain) SL1344_0743(oxaloacetate decarboxylase gamma chain (ec 4.1.1.3)),SL1344_3325(putative oxaloacetate decarboxylase gamma chain (ec 4.1.1.3)) Cluster3192 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3965(Non-specific ribonucleoside hydrolase rihC,ribonucleoside hydrolase RihC,Inosine-uridine preferring nucleoside hydrolase) b0030(ribonucleoside hydrolase 3) BN373_05061(nonspecific ribonucleoside hydrolase RihC) t0053(putative nucleoside hydrolase (IUNH family)) SL1344_0052(putative nucleoside hydrolase (IUNH family)) Cluster3193 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3983(hypothetical protein,Protein of unknown function (DUF2541)) b0013(conserved protein, UPF0412 family) BN373_04951(conserved hypothetical protein) t0011(conserved hypothetical protein) SL1344_0011(conserved hypothetical protein) Cluster3194 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3984(hypothetical protein,Uncharacterized protein conserved in bacteria,Ubiquinol-cytochrome C chaperone) b0011(conserved protein, UPF0174 family) BN373_04941(conserved hypothetical protein) t0010(conserved hypothetical protein) SL1344_0010(conserved hypothetical protein) Cluster3195 1 0 1 2 1 0 0 ROD_22911(putative nucleoside transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1546(Putative pseudouridine transporter,nucleoside transporter, NupC family,Na+ dependent nucleoside transporter C-terminus) b2161(nucleoside permease),b2164(predicted nucleoside transporter) BN373_04611(putative Na+ dependent nucleoside transporter) Cluster3196 1 0 1 1 1 0 1 ROD_48531(N-acetylgalactosamine-specific PTS system EIIC component 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.560(PTS system N-acetylgalactosamine-specific EIIC component 1,PTS system N-acetylgalactosamine-specific transporter subunit IIC,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC,PTS system, mannose/fructose/sorbose family, IIC component,PTS system sorbose-specific iic component) pseudob3134(unknown) BN373_04321(PTS system, IIC component) SL1344_4468(PTS transport system, IIC component) Cluster3197 1 1 0 0 1 1 1 ROD_11941(Major Facilitator Superfamily transporter) ENC_44660(4-hydroxyphenylacetate permease) BN373_04071(4-hydroxyphenylacetate permease) t1812(putative 4-hydroxyphenylacetate permease) SL1344_1046(putative 4-hydroxyphenylacetate permease) Cluster3198 0 1 1 1 1 0 1 ENC_44410(Uncharacterized conserved small protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4055(Uncharacterized conserved small protein,Domain of unknown function (DUF1127)) b4341(conserved protein) BN373_03841(conserved hypothetical protein) SL1344_4452(conserved hypothetical protein) Cluster3199 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.209(Macrolide-specific efflux protein macA precursor,putative efflux pump membrane fusion protein,efflux transporter, RND family, MFP subunit,HlyD family secretion protein) b3487(predicted membrane fusion protein (MFP) of efflux pump) BN373_03731(auxiliary transport protein, membrane fusion protein (MFP) family) t3935(putative HlyD-family secretion protein) SL1344_3552(putative HlyD family secretion protein) Cluster3200 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.210(Uncharacterized ABC transporter ATP-binding protein YbhF,nodulation factor exporter subunit NodI,ABC-type Na+ transport system, ATPase component,daunorubicin resistance ABC transporter, ATP-binding protein,ABC-2 family transporter protein) b3486(fused ribosome-associated ATPase: ATP-binding protein/ATP-binding protein/predicted membrane protein) BN373_03721(ABC transporter, ATP binding protein) t3936(hypothetical ABC transporter ATP-binding protein) SL1344_3551(hypothetical ABC transporter ATP-binding protein) Cluster3201 0 1 1 0 1 1 1 ENC_16370(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.242(Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF1778)) BN373_03671(conserved hypothetical protein) t2804(hypothetical protein) SL1344_2884(salmonella pathogenicity island 1 protein) Cluster3202 0 1 1 1 2 0 0 ENC_35500(Uncharacterized conserved protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3437(Cation efflux system protein CusF precursor,periplasmic copper-binding protein,Uncharacterized conserved protein,Copper binding periplasmic protein CusF) b0573(periplasmic copper-and silver-binding protein) BN373_03631(cation efflux system protein CusF),BN373_p00621(periplasmic copper-binding protein) Cluster3203 0 1 1 1 2 0 0 ENC_35490(RND family efflux transporter, MFP subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3436(Cation efflux system protein CusB precursor,copper/silver efflux system membrane fusion protein CusB,efflux transporter, RND family, MFP subunit,HlyD family secretion protein) b0574(copper/silver efflux system, membrane fusion protein) BN373_03621(cation efflux system protein CusB),BN373_p00631(copper/silver efflux system membrane fusion protein CusB) Cluster3204 0 0 0 0 5 0 0 BN373_03061(putative transposase),BN373_04271(conserved hypothetical protein),BN373_43281(conserved hypothetical protein flags: fragment),BN373_45581(conserved hypothetical protein flags: fragments),BN373_p00001(conserved hypothetical protein, integrase core domain) Cluster3205 1 0 0 1 1 1 1 ROD_42941(GntR-family transcriptional regulator) b3375(predicted DNA-binding transcriptional regulator) BN373_02751(transcriptional regulator, fadr family protein) t3915(gntR family regulatory protein) SL1344_3567(gntR family regulatory protein) Cluster3206 1 0 0 1 1 1 1 ROD_42951(fructoselysine 6-phosphate deglycase) b3371(fructoselysine-6-P-deglycase) BN373_02701(sugar isomerase (SIS)) t3916(putative phosphosugar-binding protein) SL1344_3566(putative phosphosugar-binding protein) Cluster3207 0 1 0 1 1 1 1 ENC_36070(addiction module toxin, RelE/StbE family) b1563(Qin prophage; toxin of the RelE-RelB toxin-antitoxin system) BN373_02546(unknown) t4484(conserved hypothetical protein) SL1344_4380(toxin) Cluster3208 0 1 0 1 1 1 1 ENC_36060(addiction module antitoxin, RelB/DinJ family) b1564(Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/ transcriptional repressor) BN373_02541(bifunctional antitoxin/transcriptional repressor RelB) t4483(RelB protein) SL1344_4379(antitoxin protein) Cluster3209 1 0 1 0 1 1 1 ROD_33071(putative BglB-family transcriptional antiterminator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.22(Probable licABCH operon regulator,stationary phase inducible protein CsiE,Transcriptional antiterminator,PRD domain) BN373_02531(putative transcriptional regulator/PTS system, IIA component) t4482(putative BglB-family transcriptional antiterminator) SL1344_4378(putative BglB-family transcriptional antiterminator) Cluster3210 1 1 0 0 1 1 1 ROD_33061(conserved hypothetical protein) ENC_43530(conserved hypothetical protein EF_0839/AHA_3917) BN373_02511(conserved hypothetical protein) t4481(hypothetical protein) SL1344_4377(conserved hypothetical protein) Cluster3211 1 1 0 0 1 1 1 ROD_33051(conserved hypothetical protein) ENC_43520(uncharacterized pyridoxal phosphate-dependent enzyme) BN373_02501(putative pyridoxal phosphate-dependent enzyme) t4480(hypothetical protein) SL1344_4376(conserved hypothetical protein) Cluster3212 1 1 0 0 1 1 1 ROD_33041(conserved hypothetical protein) ENC_43510(probable amidohydrolase EF_0837/AHA_3915) BN373_02491(amidohydrolase family protein) t4479(hypothetical protein) SL1344_4375(hypothetical protein) Cluster3213 1 1 0 0 1 1 1 ROD_33021(putative membrane protein) ENC_43500(conserved hypothetical protein EF_0833/AHA_3914) BN373_02481(putative membrane protein) t4478(putative membrane protein) SL1344_4374(putative membrane protein) Cluster3214 1 1 0 0 1 1 1 ROD_33011(putative exported protein) ENC_43490(conserved hypothetical protein EF_0832/AHA_3913) BN373_02471(inner membrane protein) t4477(putative membrane protein) SL1344_4373(putative membrane protein) Cluster3215 1 1 0 0 1 1 1 ROD_33001(conserved hypothetical protein) ENC_43480(conserved hypothetical protein EF_0831/AHA_3912) BN373_02461(conserved hypothetical protein) t4476(hypothetical protein) SL1344_4372(hypothetical protein) Cluster3216 1 1 0 0 1 1 1 ROD_32991(conserved hypothetical protein) ENC_43470(conserved hypothetical protein EF_0830/AHA_3911) BN373_02451(conserved hypothetical protein) t4475(hypothetical protein) SL1344_4371(hypothetical protein) Cluster3217 1 1 0 0 1 1 1 ROD_32981(conserved hypothetical protein) ENC_43460(PRD domain protein EF_0829/AHA_3910) BN373_02441(PRD domain protein) t4474(hypothetical protein) SL1344_4370(hypothetical protein) Cluster3218 1 1 1 1 1 0 0 ROD_32911(ABC transporter, permease protein) ENC_43380(monosaccharide ABC transporter membrane protein, CUT2 family (TC 3.A.1.2.-)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4219(Inner membrane ABC transporter permease protein yjfF,inner membrane ABC transporter permease protein YjfF,Predicted ABC-type sugar transport system, permease component,urea ABC transporter, permease protein UrtB,Branched-chain amino acid transport system / permease component) b4231(predicted sugar transporter subunit: membrane component of ABC superfamily) BN373_02361(putative sugar ABC transporter, permease protein) Cluster3219 1 1 1 1 1 0 0 ROD_32901(ABC transporter, permease protein) ENC_43370(monosaccharide ABC transporter membrane protein, CUT2 family (TC 3.A.1.2.-)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4220(Inner membrane ABC transporter permease protein ytfT,ribose ABC transporter permease protein,Predicted ABC-type sugar transport system, permease component,urea ABC transporter, permease protein UrtB,Branched-chain amino acid transport system / permease component) b4230(predicted sugar transporter subunit: membrane component of ABC superfamily) BN373_02351(putative sugar ABC transporter, permease protein) Cluster3220 1 1 1 1 1 0 0 ROD_32891(ABC transporter, ATP-binding protein) ENC_43360(monosaccharide ABC transporter ATP-binding protein, CUT2 family (TC 3.A.1.2.-)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4221(Ribose import ATP-binding protein RbsA,L-arabinose transporter ATP-binding protein,Predicted periplasmic lipoprotein,D-xylose ABC transporter, ATP-binding protein,ABC transporter) b4485(predicted sugar transporter subunit: ATP-binding component of ABC superfamily) BN373_02341(putative sugar ABC transporter, ATP-binding protein) Cluster3221 1 1 1 1 1 0 0 ROD_32871(ABC transporter, substrate-binding protein) ENC_43350(monosaccharide ABC transporter substrate-binding protein, CUT2 family (TC 3.A.1.2.-)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4222(ABC transporter periplasmic-binding protein ytfQ precursor,D-ribose transporter subunit RbsB,ABC-type sugar transport system, periplasmic component,D-xylose ABC transporter, D-xylose-binding protein,Periplasmic binding proteins and sugar binding domain of LacI family) b4227(galactofuranose binding proteint: periplasmic-binding component of ABC superfamily) BN373_02331(putative sugar ABC transporter, periplasmic sugar-binding protein) Cluster3222 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4347(Alpha-galactosidase,alpha-galactosidase,Family 4 glycosyl hydrolase C-terminal domain) b4119(alpha-galactosidase, NAD(P)-binding) BN373_01171(alpha-galactosidase) t4205(alpha-galactosidase) SL1344_4235(alpha-galactosidase) Cluster3223 0 0 1 1 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4348(Melibiose operon regulatory protein,DNA-binding transcriptional regulator MelR,Adenosine deaminase,YSIRK-targeted surface antigen transcriptional regulator,Bacterial regulatory helix-turn-helix proteins, AraC family) b4118(DNA-binding transcriptional dual regulator) BN373_01161(melibiose operon regulatory protein) t4204(melibiose operon regulatory protein) SL1344_4234(melibiose operon regulatory protein) Cluster3224 0 1 1 0 1 1 1 ENC_05020(Putative effector of murein hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4406(Inner membrane protein yohK,hypothetical protein,Cytidylyltransferase,conserved hypothetical protein,LrgB-like family) BN373_00781(LrgB family protein) t4178(putative membrane protein) SL1344_4208(putative membrane protein) Cluster3225 0 1 1 0 1 1 1 ENC_05010(Putative effector of murein hydrolase LrgA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4407(Holin-like protein CidA,holin-like protein,Putative effector of murein hydrolase LrgA,LrgA family) BN373_00771(LrgA family protein) t4177(putative membrane protein) SL1344_4207(putative membrane protein) Cluster3226 1 1 0 0 1 1 1 ROD_34491(putative glutathione S transferase) ENC_04970(Glutathione S-transferase) BN373_00731(putative glutathione S-transferase) t4173(putative glutathione S transferase) SL1344_4203(putative glutathione S transferase) Cluster3227 1 0 0 1 1 1 1 ROD_34481(redox-sensitive transcriptional activator) b4063(DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing) BN373_00721(redox-sensitive transcriptional activator SoxR) t4172(SoxR protein) SL1344_4202(SoxR protein) Cluster3228 0 1 2 1 1 0 0 ENC_31660(Threonine dehydrogenase and related Zn-dependent dehydrogenases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4474(Sorbitol dehydrogenase,L-threonine 3-dehydrogenase,L-threonine 3-dehydrogenase,Zinc-binding dehydrogenase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.820(Alcohol dehydrogenase,ethanol-active dehydrogenase/acetaldehyde-active reductase,L-threonine 3-dehydrogenase,Zinc-binding dehydrogenase) b4465(predicted dehydrogenase) BN373_00091(L-sorbose 1-phosphate reductase) Cluster3229 0 0 0 0 0 4 0 t2718(hypothetical protein),t2720(hypothetical protein),t2722(hypothetical protein),t2724(hypothetical protein) Cluster3230 1 0 0 0 0 2 1 pseudoROD_35291(conserved hypothetical protein (pseudogene)) t4224(putative acetyltransferase),t4359(conserved hypothetical protein) SL1344_4254(Putative acetyltransferase) Cluster3231 1 0 0 0 0 2 1 pseudoROD_48171(large repetitive protein (pseudogene)) t4166(large repetitive protein),t4167(large repetitive protein) SL1344_4197(large repetitive protein) Cluster3232 0 0 0 0 0 2 2 t0034(possible sulfatase),t0040(possible sulfatase) SL1344_0033(possible sulfatase),SL1344_0039(possible sulfatase) Cluster3233 1 0 0 1 0 1 1 ROD_50882(conserved hypothetical protein) b4402(predicted protein) t4638(conserved hypothetical protein) SL1344_4526(conserved hypothetical protein) Cluster3234 3 0 0 0 0 1 0 ROD_47811(putative T3SS effector protein EspN2-2),pseudoROD_12081(putative T3SS effector protein EspN1 (pseudogene)),pseudoROD_31851(putative T3SS effector protein EspN2-1 (pseudogene)) t1557(hypothetical protein) Cluster3235 1 0 0 0 0 1 2 ROD_38071(putative membrane protein) t0865(hypothetical protein) SL1344_1988(conserved hypothetical protein),SL1344_2880(salmonella pathogenicity island 1 protein) Cluster3236 1 0 0 1 0 1 1 ROD_33171(pyrBI operon leader peptide) b4246(pyrBI operon leader peptide) t4496(pyrBI operon leader peptide) SL1344_4392(pyrBI operon leader peptide) Cluster3237 1 0 0 1 0 1 1 ROD_30521(CRISPR-associated protein) b2754(probable ssRNA endonuclease, CRISP-associated protein) t2838(conserved hypothetical protein) SL1344_2916(conserved hypothetical protein) Cluster3238 1 0 0 1 0 1 1 ROD_30511(CRISPR-associated protein) b2755(CRISP-associated protein Cas1, DNA endonuclease; DNA repair protein) t2839(conserved hypothetical protein) SL1344_2917(conserved hypothetical protein) Cluster3239 1 0 0 1 0 1 1 ROD_30501(CRISPR-associated protein) b2756(CRISPR RNA precursor cleavage enzyme; CRISP RNA (crRNA) containing Cascade antiviral complex protein) t2840(conserved hypothetical protein) SL1344_2918(conserved hypothetical protein) Cluster3240 1 0 0 1 0 1 1 ROD_30491(CRISPR-associated protein) b2757(CRISP RNA (crRNA) containing Cascade antiviral complex protein) t2841(hypothetical protein) SL1344_2919(hypothetical protein) Cluster3241 1 0 0 1 0 1 1 ROD_30481(CRISPR-associated protein) b2758(CRISP RNA (crRNA) containing Cascade antiviral complex protein) t2842(hypothetical protein) SL1344_2920(hypothetical protein) Cluster3242 1 0 0 1 0 1 1 ROD_30461(CRISPR-associated protein) b2760(CRISP RNA (crRNA) containing Cascade antiviral complex protein) t2844(hypothetical protein) SL1344_2922(hypothetical protein) Cluster3243 1 0 0 1 0 1 1 ROD_30451(CRISPR-associated protein) b2761(Cas3 predicted helicase needed for Cascade anti-viral activity) t2845(conserved hypothetical protein) SL1344_2923(conserved hypothetical protein) Cluster3244 1 0 0 1 0 1 1 ROD_29001(conserved hypothetical protein) b2846(conserved protein with bipartite regulator domain) t3761(conserved hypothetical protein) SL1344_3722(conserved hypothetical protein) Cluster3245 1 0 0 1 0 1 1 ROD_26081(putative prophage exported protein) b1553(Rz-like equivalent, Qin prophage) t1898(putative secreted protein) SL1344_1803(exported bacteriophage protein) Cluster3246 4 0 0 0 0 0 0 ROD_20851(conserved hypothetical protein),ROD_20861(conserved hypothetical protein),ROD_20881(conserved hypothetical protein),ROD_20891(conserved hypothetical protein) Cluster3247 1 0 0 1 0 1 1 ROD_13961(conserved hypothetical protein) b1667(predicted monooxygenase) t4044(conserved hypothetical protein) SL1344_3428(conserved hypothetical protein) Cluster3248 3 0 0 1 0 0 0 ROD_11911(putative adhesin autotransporter),ROD_11971(putative adhesin autotransporter),ROD_16841(putative adhesin autotransporter) b1202(predicted adhesin) Cluster3249 1 0 0 1 0 1 1 ROD_09631(putative amino acid permease) b0899(predicted transporter) t1965(probable transport protein) SL1344_0906(probable transport protein) Cluster3250 1 0 0 1 0 1 1 ROD_09021(putative phage tail fibre assembly protein) b2354(CPS-53 (KpLE1) prophage; conserved protein) t3435(conserved hypothetical protein) SL1344_2209(tail fiber assembly protein) Cluster3251 4 0 0 0 0 0 0 ROD_06971(ISCro2 transposase),ROD_27931(ISCro2 transposase),ROD_38181(ISCro2 transposase),pseudoROD_40991(putative IS4 family transposase (pseudogene)) Cluster3252 1 0 0 1 0 1 1 ROD_00213(putative membrane protein) b0024(predicted protein) t0046(conserved hypothetical protein) SL1344_0045(conserved hypothetical protein) Cluster3253 0 0 4 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.190(Domain of unknown function (DUF3330)),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.28(Domain of unknown function (DUF3330)),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.9(Domain of unknown function (DUF3330)),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.10(Domain of unknown function (DUF3330)) Cluster3254 0 0 4 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.185(Dihydropteroate synthase,dihydropteroate synthase,dihydropteroate synthase,Pterin binding enzyme),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.23(Dihydropteroate synthase,dihydropteroate synthase,dihydropteroate synthase,Pterin binding enzyme),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.4(Dihydropteroate synthase,dihydropteroate synthase,dihydropteroate synthase,Pterin binding enzyme),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.5(Dihydropteroate synthase,dihydropteroate synthase,dihydropteroate synthase,Pterin binding enzyme) Cluster3255 1 0 3 0 0 0 0 ROD_12321(Beta-lactamase) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.12(Beta-lactamase CTX-M-1 precursor,beta-lactamase TEM,Beta-lactamase),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.31(Beta-lactamase CTX-M-1 precursor,beta-lactamase TEM,Beta-lactamase),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.13(Beta-lactamase CTX-M-1 precursor,beta-lactamase TEM,Beta-lactamase) Cluster3256 0 0 4 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.10(Putative transposon Tn552 DNA-invertase bin3,Resolvase, N terminal domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.191(Putative transposon Tn552 DNA-invertase bin3,Resolvase, N terminal domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.29(Putative transposon Tn552 DNA-invertase bin3,Resolvase, N terminal domain),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.11(Putative transposon Tn552 DNA-invertase bin3,Resolvase, N terminal domain) Cluster3257 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.793(Protein of unknown function (DUF1202)) b2956(conserved protein) t3017(conserved hypothetical protein) SL1344_3080(conserved hypothetical protein) Cluster3258 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.713(Hydrogenase-2 operon protein hybE,hydrogenase 2-specific chaperone,[NiFe] hydrogenase assembly chaperone, HybE family,Protein of unknown function (DUF3457)) b2992(hydrogenase 2-specific chaperone) t3066(hydrogenase-2 component protein) SL1344_3119(hydrogenase-2 component protein) Cluster3259 1 0 1 0 0 1 1 ROD_35871(arylsulfate sulfotransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.658(Arylsulfotransferase (ASST)) t3112(probable arylsulfate sulfotransferase) SL1344_3165(probable arylsulfate sulfotransferase) Cluster3260 1 0 1 0 0 1 1 ROD_35881(thiol:disulfide interchange protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.657(Thiol:disulfide interchange protein DsbA-like precursor,periplasmic protein disulfide isomerase I,Protein-disulfide isomerase,DSBA-like thioredoxin domain) t3113(disulfide isomerase) SL1344_3166(disulfide isomerase) Cluster3261 1 0 1 0 0 1 1 ROD_35891(putative disulfide bond formation protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.656(Disulfide oxidoreductase,putative disulfide oxidoreductase,Disulfide bond formation protein DsbB) t3114(disulfide isomerase) SL1344_3167(disulfide isomerase) Cluster3262 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.605(vancomycin high temperature exclusion protein,DUF218 domain) b3086(conserved protein, SanA family, DUF218 superfamily) t3142(conserved hypothetical protein) SL1344_3195(conserved hypothetical protein) Cluster3263 0 0 3 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4908(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4909(Eco57I restriction-modification methylase),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.7(Type I restriction-modification system methyltransferase subunit,type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family,N-6 DNA Methylase) SL1344_4424(type II restriction enzyme) Cluster3264 1 0 2 1 0 0 0 ROD_49701(putative DNA repair protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4866(hypothetical protein,hypothetical protein,DNA repair protein RadC,Protein of unknown function (DUF2466)),Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.19(hypothetical protein,hypothetical protein,DNA repair protein RadC,Protein of unknown function (DUF2466)) b2002(CP4-44 prophage; predicted DNA repair protein) Cluster3265 1 0 2 0 0 0 1 pseudoROD_49621(conserved hypothetical protein (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4860(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.12(hypothetical protein) pseudoSL1344_3718(putative ATP binding protein (pseudogene)) Cluster3266 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4724(Anaerobic sulfatase-maturating enzyme,anaerobic sulfatase-maturase,Predicted metal-binding protein,anaerobic sulfatase maturase,Radical SAM superfamily) b3800(predicted regulator of arylsulfatase activity) t3331(putative regulatory protein) SL1344_3920(putative regulatory protein) Cluster3267 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4704(Protein of unknown function (DUF2628)) b3817(predicted inner membrane protein) t3344(putative membrane protein) SL1344_3907(conserved hypothetical protein) Cluster3268 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4703(Inner membrane protein yigG,hypothetical protein) b3818(conserved inner membrane protein) t3343(conserved hypothetical protein) SL1344_3908(conserved hypothetical protein) Cluster3269 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4602(hypothetical protein) b3896(conserved lipoprotein) t3580(putative lipoprotein) SL1344_3988(putative lipoprotein) Cluster3270 1 0 1 1 0 0 1 ROD_37961(fructose-like specific PTS system EIIC component 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4552(EIIBCA-Man,putative PTS system fructose-like transporter subunit EIIC,PTS system, Fru family, IIC component) b3949(predicted enzyme IIC component of PTS) SL1344_4061(PTS system, protein component IIC (phosphotransferase enzyme ii, c component)) Cluster3271 1 0 1 1 0 0 1 ROD_37941(formate acetyltransferase 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4550(4-hydroxyphenylacetate decarboxylase large subunit,putative formate acetyltransferase 2,glycyl radical enzyme, PFL2/glycerol dehydratase family,Pyruvate formate lyase) b3951(predicted formate acetyltransferase 2 (pyruvate formate lyase II)) SL1344_4063(formate acetyltransferase 2 (ec 2.3.1.54) (pyruvate formate-lyase 2)) Cluster3272 1 0 1 1 0 0 1 ROD_37931(pyruvate formate-lyase 2 activating enzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4549(4-hydroxyphenylacetate decarboxylase activating enzyme,pyruvate formate lyase II activase,glycyl-radical enzyme activating protein family,Radical SAM superfamily) b3952(pyruvate formate lyase II activase) SL1344_4064(pyruvate formate-lyase 2 activating enzyme (ec 1.97.1.4) (pfl-activating enzyme)) Cluster3273 1 0 1 1 0 0 1 ROD_37921(fructose-like specific PTS system EIIB component 3) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4548(EIIBCA-Man,putative PTS system fructose-like transporter subunit EIIB,PTS system, Fru family, IIB component,PTS system, Lactose/Cellobiose specific IIB subunit) b3953(predicted enzyme IIB component of PTS) SL1344_4065(PTS system, component IIB) Cluster3274 1 0 1 1 0 1 0 ROD_34631(cytochrome c-type biogenesis protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4397(Cytochrome c-type biogenesis protein CcmH precursor,formate-dependent nitrite reductase complex subunit NrfF,Uncharacterized protein involved in biosynthesis of c-type cytochromes,cytochrome c nitrite reductase, accessory protein NrfF,Cytochrome C biogenesis protein) b4075(heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfF) t4188(cytochrome c-type biogenesis protein) Cluster3275 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4351(Arginine/agmatine antiporter,arginine:agmatin antiporter,Amino acid transporters,transporter, basic amino acid/polyamine antiporter (APA) family,Amino acid permease) b4115(arginine:agmatin) t4201(putative amino acid permease) SL1344_4231(putative amino acid permease) Cluster3276 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4350(HTH-type transcriptional regulator AdiY,DNA-binding transcriptional regulator GadX,DNA gyrase inhibitor,YSIRK-targeted surface antigen transcriptional regulator,Bacterial regulatory helix-turn-helix proteins, AraC family) b4116(DNA-binding transcriptional activator) t4202(putative AraC family regulatory protein) SL1344_4232(putative AraC family regulatory protein) Cluster3277 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4349(Biodegradative arginine decarboxylase,arginine decarboxylase,Orn/Lys/Arg decarboxylase, major domain) b4117(arginine decarboxylase) t4203(arginine decarboxylase) SL1344_4233(arginine decarboxylase) Cluster3278 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4310(entericidin A,Predicted small secreted protein,Entericidin EcnA/B family) b4410(entericidin A membrane lipoprotein, antidote entericidin B) t4387(entericidin A precursor) SL1344_4272(putative entericidin A precursor) Cluster3279 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4275(Uncharacterized protein conserved in bacteria,Uncharacterized protein conserved in bacteria (DUF2170)) b4181(conserved protein, DUF2170 family) t4421(conserved hypothetical protein) SL1344_4303(conserved hypothetical protein) Cluster3280 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4273(Protein of unknown function (DUF2491)) b4183(conserved protein, DUF2491 family) t4424(conserved hypothetical protein) SL1344_4306(conserved hypothetical protein) Cluster3281 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4272(hypothetical protein,Predicted membrane protein,Domain of Unknown Function (DUF350)) b4184(inner membrane protein, UPF0719 family) t4425(putative membrane protein) SL1344_4307(putative membrane protein) Cluster3282 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4271(hypothetical protein,Protein of unknown function (DUF1190)) b4185(conserved protein, DUF1190 family) t4426(conserved hypothetical protein) SL1344_4308(conserved hypothetical protein) Cluster3283 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4270(Bifunctional glutathionylspermidine synthetase/amidase,bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase,Glutathionylspermidine synthase) b4186(glutathionylspermidine synthase homolog) t4427(conserved hypothetical protein) SL1344_4309(conserved hypothetical protein) Cluster3284 1 0 3 0 0 0 0 ROD_49761(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4136(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4873(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4874(hypothetical protein) Cluster3285 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4104(HTH-type transcriptional repressor glcR,DNA-bindng transcriptional repressor SrlR,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,Bacterial regulatory proteins, deoR family) b4300(KpLE2 phage-like element; predicted DNA-binding transcriptional regulator) t1527(putative regulatory protein) SL1344_1548(putative regulatory protein) Cluster3286 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4103(Ribulose-phosphate 3-epimerase,epimerase,Pentose-5-phosphate-3-epimerase,ribul ose-phosphate 3-epimerase,Ribulose-phosphate 3 epimerase family) b4301(KpLE2 phage-like element; predicted epimerase) t1526(putative ribulose-5-phosphate 3-epimerase) SL1344_1547(putative ribulose-5-phosphate 3-epimerase) Cluster3287 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4102(Ascorbate-specific phosphotransferase enzyme IIA component,PTS system L-ascorbate-specific transporter subunit IIA,Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2) b4302(KpLE2 phage-like element; predicted phosphotransferase enzyme IIA component) t1525(putative phosphotransferase enzyme) SL1344_1546(putative phosphotransferase enzyme) Cluster3288 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4100(PTS system galactitol-specific EIIC component,PTS system, galactitol-specific IIC component,PTS system sugar-specific permease component) b4304(KpLE2 phage-like element; predicted phosphotransferase enzyme IIC component) t1523(putative phosphotransferase enzyme) SL1344_1544(putative phosphotransferase enzyme) Cluster3289 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4099(Galactitol-specific phosphotransferase enzyme IIB component,PTS system galactitol-specific transporter subunit IIB,Phosphotransferase system, galactitol-specific IIB component,PTS system, Lactose/Cellobiose specific IIB subunit) b4565(predicted enzyme IIB component of PTS) t1522(putative phosphotransferase enzyme) SL1344_1543(putative phosphotransferase enzyme) Cluster3290 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4098(Putative aminopeptidase ysdC,exoaminopeptidase,glutamyl aminopeptidase,M42 glutamyl aminopeptidase) b4305(KpLE2 phage-like element; predicted endoglucanase with Zn-dependent exopeptidase domain) t1521(conserved hypothetical protein) SL1344_1542(conserved hypothetical protein) Cluster3291 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4089(N-acetylneuraminate epimerase precursor,N-acetylneuraminic acid mutarotase,mutatrotase, YjhT family,Kelch motif) b4310(N-acetylneuraminic acid mutarotase) t1790(conserved hypothetical protein) SL1344_1068(conserved hypothetical protein) Cluster3292 1 0 1 1 0 0 1 ROD_34201(T6SS protein Cts2D) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4070(Anti-adapter protein iraD,DNA replication/recombination/repair protein,type VI secretion system lysozyme-like protein,Gene 25-like lysozyme) b4326(RpoS stabilzer after DNA damage, anti-RssB factor) SL1344_3104(conserved hypothetical protein) Cluster3293 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4050(EcoKMrr,Restriction endonuclease) b4351(methylated adenine and cytosine restriction protein) t4577(mrr restriction system protein) SL1344_4458(Mrr restriction system protein) Cluster3294 1 0 1 0 0 1 1 ROD_00191(putative transport protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3972(Inner membrane symporter yihP,putative symporter YagG,sugar (Glycoside-Pentoside-Hexuronide) transporter,Major Facilitator Superfamily) t0044(putative transport protein) SL1344_0043(putative transport protein) Cluster3295 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3706(RNA-splicing ligase RtcB,hypothetical protein,release factor H-coupled RctB family protein,Uncharacterized protein family UPF0027) pseudob0235(unknown) t2536(conserved hypothetical protein) pseudoSL1344_0310(conserved hypothetical protein) Cluster3296 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3705(Peptide chain release factor 1,peptide chain release factor-like protein,putative peptide chain release factor H,RF-1 domain) pseudob0236(unknown) t2535(putative peptide chain release factor) SL1344_0311(putative peptide chain release factor) Cluster3297 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3666(Inner membrane protein ykgB,Predicted membrane protein,Protein of unknown function, DUF417) b0301(inner membrane protein, DUF417 family) t2296(putative membrane protein) SL1344_0554(putative membrane protein) Cluster3298 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3665(Mercuric reductase,pyridine nucleotide-disulfide oxidoreductase,Uncharacterized conserved protein,dihydrolipoyl dehydrogenase,Pyridine nucleotide-disulphide oxidoreductase) b0304(predicted pyridine nucleotide-disulfide oxidoreductase) t2298(probable pyridine nucleotide-disulfide oxidoreductase) SL1344_0552(probable pyridine nucleotide-disulfide oxidoreductase) Cluster3299 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3638(Threonine efflux protein,threonine efflux system,homoserine/Threonine efflux protein,LysE type translocator) b0328(amino acid exporter for proline, lysine, glutamate, homoserine) t2499(RhtC-like transporter) SL1344_0360(RhtC-like transporter) Cluster3300 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3473(Negative regulator of allantoin and glyoxylate utilization operons,DNA-binding transcriptional repressor AllR,beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family,Bacterial transcriptional regulator) b0506(DNA-binding transcriptional repressor for all (allantoin) and gcl (glyoxylate) operons; glyoxylate-induced) t2344(negative regulator of allantoin and glyoxylate utilization operons) SL1344_0509(negative regulator of allantoin and glyoxylate utilization operons) Cluster3301 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3472(Glyoxylate carboligase,glyoxylate carboligase,Glyoxylate carboligase,glyoxylate carboligase,Thiamine pyrophosphate enzyme, N-terminal TPP binding domain) b0507(glyoxylate carboligase) t2343(glyoxylate carboligase) SL1344_0510(glyoxylate carboligase) Cluster3302 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3471(Hydroxypyruvate isomerase,hydroxypyruvate isomerase,Hydroxypyruvate isomerase,hydroxypyruvate isomerase,Xylose isomerase-like TIM barrel) b0508(hydroxypyruvate isomerase) t2342(hydroxypyruvate isomerase) SL1344_0511(hydroxypyruvate isomerase) Cluster3303 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3470(2-hydroxy-3-oxopropionate reductase,tartronate semialdehyde reductase,Uncharacterized protein conserved in bacteria,2-hydroxy-3-oxopropionate reductase,NAD binding domain of 6-phosphogluconate dehydrogenase) b0509(tartronate semialdehyde reductase, NADH-dependent) t2341(2-hydroxy-3-oxopropionate reductase) SL1344_0512(2-hydroxy-3-oxopropionate reductase) Cluster3304 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3467(Putative purine permease ybbY,putative uracil/xanthine transporter,xanthine permease,Permease family) b0513(predicted uracil/xanthine transporter) t2337(putative permease protein) SL1344_0517(putative permease protein) Cluster3305 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3466(Glycerate kinase,glycerate kinase II,glycerate kinase,Glycerate kinase family) b0514(glycerate kinase II) t2336(glycerate kinase) SL1344_0518(glycerate kinase) Cluster3306 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3464(hypothetical protein,hypothetical protein,Uncharacterized conserved protein, contains double-stranded beta-helix domain,putative allantoin catabolism protein,Cupin domain) b0515(conserved protein) t2335(conserved hypothetical protein) SL1344_0519(conserved hypothetical protein) Cluster3307 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3462(Ureidoglycolate dehydrogenase,ureidoglycolate dehydrogenase,Malate/L-lactate dehydrogenases,ureidoglycolate dehydrogenase,Malate/L-lactate dehydrogenase) b0517(ureidoglycolate dehydrogenase) t2333(ureidoglycolate dehydrogenase) SL1344_0521(ureidoglycolate dehydrogenase) Cluster3308 2 0 1 0 0 0 1 ROD_19961(hypothetical prophage protein),ROD_36891(hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3063(hypothetical protein) SL1344_2589(putative bacteriophage protein) Cluster3309 1 0 1 1 0 1 0 ROD_09031(putative phage tail fibre assembly protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3036(Bacteriophage tail assembly protein,Caudovirales tail fibre assembly protein) b1156(e14 prophage; predicted tail fiber assembly protein) t1349(putative bacteriophage tail fiber assembly protein) Cluster3310 1 0 1 0 0 1 1 ROD_09051(putative phage tail protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3034(Bacteriophage P2-related tail formation protein,phage tail protein I,Phage tail protein (Tail_P2_I)) t1352(putative bacteriophage tail fiber protein) SL1344_4136(putative bacteriophage protein) Cluster3311 1 0 1 0 0 1 1 ROD_09061(putative phage baseplate protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3033(Uncharacterized homolog of phage Mu protein gp47,conserved hypothetical protein,Baseplate J-like protein) t1353(putative bacteriophage baseplate assembly protein) SL1344_4137(putative bacteriophage protein) Cluster3312 1 0 1 0 0 1 1 ROD_09071(putative phage baseplate protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3032(Gene 25-like lysozyme) t1354(putative bacteriophage baseplate protein) SL1344_4138(putative bacteriophage protein) Cluster3313 1 0 1 0 0 1 1 ROD_09081(putative phage tail spike protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3031(Phage P2 baseplate assembly protein gpV,phage baseplate assembly protein V,Phage-related baseplate assembly protein) t1355(putative bacteriophage baseplate protein) SL1344_4142(bacteriophage tail protein) Cluster3314 1 0 1 0 0 1 1 ROD_09091(putative phage tail protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3030(Phage protein D,Phage late control gene D protein (GPD)) t1356(putative bacteriophage regulatory protein) SL1344_4143(predicted bacteriophage protein) Cluster3315 1 0 1 0 0 1 1 ROD_09101(putative phage tail protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3029(Phage Tail Protein X) t1357(putative bacteriophage tail fiber protein) SL1344_4144(bacteriophage tail protein) Cluster3316 1 0 1 0 0 1 1 ROD_09111(conserved hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3028(Phage protein U,Phage P2 GpU) t1358(hypothetical protein) SL1344_4145(predicted bacteriophage protein) Cluster3317 1 0 1 0 0 1 1 ROD_09121(putative phage tail tape-measure protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3027(Phage-related protein,phage tail tape measure protein, TP901 family, core region,Phage-related minor tail protein) t1359(putative bacteriophage protein) SL1344_4146(bacteriophage tail protein) Cluster3318 1 0 1 0 0 1 1 ROD_09131(conserved hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3026(hypothetical protein) t1360(hypothetical protein) SL1344_4147(hypothetical protein) Cluster3319 1 0 1 0 0 1 1 ROD_09151(putative phage tail tube protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3024(phage major tail tube protein,Phage tail tube protein FII) t1362(tail core protein) SL1344_4148(bacteriophage tail protein) Cluster3320 1 0 1 0 0 1 1 ROD_09161(putative phage tail sheath protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3023(Phage tail sheath protein) t1363(bacteriophage tail sheath protein) SL1344_4149(Phage tail sheath protein) Cluster3321 1 0 1 0 0 1 1 ROD_09171(conserved hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3022(hypothetical protein) t1364(hypothetical protein) SL1344_4150(hypothetical bacteriophage protein) Cluster3322 1 0 1 0 0 1 1 ROD_09181(conserved hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3021(Gp37 protein) t1365(hypothetical protein) SL1344_4151(hypothetical protein) Cluster3323 1 0 1 0 0 1 1 ROD_09291(putative prophage membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3010(hypothetical protein) t1376(putative membrane protein) SL1344_4152(hypothetical bacteriophage protein) Cluster3324 1 0 1 0 0 1 1 ROD_09311(putative phage lytic transglycosylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3008(membrane-bound lytic transglycosylase F,Transglycosylase SLT domain) t1379(hypothetical protein) SL1344_4153(endolysin) Cluster3325 1 0 1 0 0 1 1 ROD_09321(putative prophage exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3007(hypothetical protein) t1380(hypothetical protein) SL1344_4154(hypothetical bacteriophage protein) Cluster3326 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.299(transposase, IS605 OrfB family,Probable transposase) b1432(IS609 transposase B) t0102(putative IS element transposase) SL1344_2563(putative virulence factor) Cluster3327 1 0 1 0 0 1 1 ROD_09461(putative prophage transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2985(Uncharacterized conserved protein,Mor transcription activator family) t1397(putative bacteriophage transcriptional regulator) SL1344_4155(putative regulatory protein) Cluster3328 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2984(Uncharacterized metalloprotease yggG,heat shock protein HtpX,Putative Zn-dependent protease, contains TPR repeats,Peptidase family M48) b0909(predicted peptidase with chaperone function) t1955(putative lipoprotein) SL1344_0916(putative lipoprotein) Cluster3329 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.298(hypothetical protein) b3402(predicted inner membrane protein) t4007(putative membrane protein) SL1344_3466(putative membrane protein) Cluster3330 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2926(Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit,hydrogenase 1 b-type cytochrome subunit,Cytochrome b,Ni/Fe-hydrogenase, b-type cytochrome subunit,Cytochrome b(N-terminal)/b6/petB) b0974(hydrogenase 1, b-type cytochrome subunit) t1088(probable Ni/Fe-hydrogenase 1 b-type cytochrome subunit) SL1344_1716(probable Ni/Fe-hydrogenase 1 b-type cytochrome subunit) Cluster3331 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2925(Hydrogenase 2 maturation protease,hydrogenase 1 maturation protease,hydrogenase expression/formation protein,Hydrogenase maturation protease) b0975(hydrogenase 1 maturation protease) t1087(hydrogenase-1 operon protein HyaD) SL1344_1717(hydrogenase-1 operon protein HyaD) Cluster3332 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2924(Hydrogenase-1 operon protein hyaE,hydrogenase-1 operon protein HyaE,Hydrogenase-1 expression protein HyaE) b0976(probable HyaA chaperone) t1086(hydrogenase-1 operon protein HyaE) SL1344_1718(hydrogenase-1 operon protein HyaE) Cluster3333 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2923(HupH hydrogenase expression protein, C-terminal conserved region) b0977(protein involved in nickel incorporation into hydrogenase-1 proteins) t1085(hydrogenase-1 operon protein HyaF) SL1344_1719(hydrogenase-1 operon protein HyaF) Cluster3334 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2921(Cytochrome bd-II oxidase subunit 2,cytochrome bd-II oxidase subunit 2,cytochrome d ubiquinol oxidase, subunit II,Cytochrome oxidase subunit II) b0979(cytochrome bd-II oxidase, subunit II) t1083(probable cytochrome oxidase subunit II) SL1344_1721(probable cytochrome oxidase subunit II) Cluster3335 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2915(Sensor protein torS,hybrid sensory histidine kinase TorS,Uncharacterized domain of BarA-like signal transduction histidine kinases,TMAO reductase sytem sensor TorS,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b0993(hybrid sensory histidine kinase in two-component regulatory system with TorR) t3692(two-component sensor protein histidine protein kinase) SL1344_3792(Two-component sensor protein histidine protein kinase) Cluster3336 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2914(Periplasmic protein torT precursor,TMAO reductase system periplasmic protein TorT,ABC-type sugar transport system, periplasmic component,TMAO reductase system periplasmic protein TorT,Periplasmic binding proteins and sugar binding domain of LacI family) b0994(periplasmic sensory protein associated with the TorRS two-component regulatory system) t3693(Solute binding receptor protein) SL1344_3791(Solute binding receptor protein) Cluster3337 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2912(Cytochrome c-type protein TorC,trimethylamine N-oxide reductase cytochrome c-type subunit,trimethylamine-N-oxide reductase c-type cytochrome TorC,NapC/NirT cytochrome c family, N-terminal region) b0996(trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit) t3695(hypothetical protein) SL1344_3789(cytochrome c-type protein) Cluster3338 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2910(Chaperone protein TorD,chaperone protein TorD,Uncharacterized component of anaerobic dehydrogenases,DMSO reductase family type II enzyme chaperone,Nitrate reductase delta subunit) b0998(chaperone involved in maturation of TorA subunit of trimethylamine N-oxide reductase system I) t3697(TorD protein) SL1344_3787(TorD protein) Cluster3339 1 0 1 1 0 0 1 ROD_11161(cytochrome b561 homolog) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2859(Cytochrome b561 homolog 2,cytochrome b561,Uncharacterized conserved protein,Cytochrome b(N-terminal)/b6/petB) b1057(predicted cytochrome b561) SL1344_1095(cytochrome b561 homolog 2) Cluster3340 1 0 1 1 0 0 1 ROD_37291(transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.280(Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain) b3422(sigma 54-dependent transcriptional regulator of rtcBA expression) SL1344_3488(transcriptional regulatory protein) Cluster3341 0 0 1 2 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2751(Phage DNA packaging protein Nu1) b0560(DLP12 prophage; DNA packaging protein),pseudob1548(unknown) SL1344_2573(putative DNA packaging protein) Cluster3342 1 0 1 0 0 1 1 ROD_02931(putative prophage transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2666(DNA-binding transcriptional regulator Nlp,Predicted transcriptional regulator) t0490(putative DNA-binding protein) SL1344_2343(putative DNA-binding protein) Cluster3343 0 0 1 3 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2630(hypothetical protein) b4419(toxic polypeptide, small),b4421(toxic polypeptide, small),b4423(toxic polypeptide, small) Cluster3344 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2569(DNA replication protein dnaC,putative replication protein,DNA replication protein,chromosomal replication initiator protein DnaA,IstB-like ATP binding protein) b1360(Rac prophage; predicted DNA replication protein) t1917(putative DNA replication protein) SL1344_0953(DNA Replication Protein) Cluster3345 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2458(Thiosulfate sulfurtransferase PspE precursor,thiosulfate:cyanide sulfurtransferase,Uncharacterized conserved protein,phage shock operon rhodanese PspE,Rhodanese-like domain) b1308(thiosulfate:cyanide sulfurtransferase (rhodanese)) t1591(phage shock protein E precursor) SL1344_1616(bacteriophage shock protein E precursor) Cluster3346 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2435(MscS family inner membrane protein YnaI,mechanosensitive channel MscS,Mechanosensitive ion channel) b1330(MscS family inner membrane protein) t1567(putative membrane protein) SL1344_1594(putative membrane protein) Cluster3347 1 0 1 1 0 0 1 ROD_20811(putative outer membrane autotransporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2406(hypothetical protein) pseudob4492(unknown) SL1344_3445(putative surface-exposed virulence protein BigA) Cluster3348 0 0 1 3 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2367(Transposase,Transposase DDE domain) b1460(conserved protein),b3484(predicted transposase),pseudob0705(unknown) Cluster3349 1 0 1 0 0 1 1 ROD_31541(GntR-family transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.218(hypothetical protein,DNA-binding transcriptional repressor MngR,Transcriptional regulators,phosphonate metabolism transcriptional regulator PhnF,UTRA domain) t3733(putative GntR-family transcriptional regulator) SL1344_3751(putative GntR-family transcriptional regulator) Cluster3350 1 0 1 0 0 1 1 ROD_31551(PTS system EIIA component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.217(PTS system galactitol-specific transporter subunit IIA,PTS system, fructose subfamily, IIA component,Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2) t3734(hypothetical protein) SL1344_3750(putative phosphoenolpyruvate-dependent sugar phosphotransferase system, eiia 2) Cluster3351 1 0 1 0 0 1 1 ROD_31561(PTS system EIIB component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.216(Galactitol-specific phosphotransferase enzyme IIB component,PTS system galactitol-specific transporter subunit IIB,Phosphotransferase system, galactitol-specific IIB component,PTS system, Lactose/Cellobiose specific IIB subunit) t3735(putative IIB component of PTS system) SL1344_3749(putative IIB component of PTS system) Cluster3352 1 0 1 2 0 0 0 ROD_10781(putative T3SS effector EspL2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2159(hypothetical protein) b4017(ankyrin repeat protein),pseudob4494(unknown) Cluster3353 1 0 1 0 0 1 1 ROD_31571(PTS system EIIC component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.215(PTS system galactitol-specific EIIC component,PTS system, galactitol-specific IIC component,PTS system sugar-specific permease component) t3736(putative IIC component of PTS system) SL1344_3748(PTS system, galactitol-specific IIC component) Cluster3354 1 0 1 0 0 1 1 ROD_31581(carbohydrate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.214(L-fuculokinase,L-fuculokinase,L-rhamnose isomerase,xylulokinase,FGGY family of carbohydrate kinases, N-terminal domain) t3737(putative carbohydrate kinase) SL1344_3747(putative sugar (pentulose and hexulose) kinase) Cluster3355 1 0 1 0 0 1 1 ROD_31601(putative PTS system phosphocarrier protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.213(Catabolite repression HPr,phosphocarrier protein HPr,Uncharacterized protein conserved in bacteria,phosphocarrier, HPr family,PTS HPr component phosphorylation site) t3739(putative phosphocarrier protein of PTS system) SL1344_3745(putative phosphocarrier protein of PTS system) Cluster3356 1 0 1 1 0 0 1 ROD_12671(putative signal transduction protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2094(Diguanylate cyclase DosC,putative diguanylate cyclase YedQ,Response regulator containing a CheY-like receiver domain and a GGDEF domain,diguanylate cyclase (GGDEF) domain,GGDEF domain) b1786(predicted diguanylate cyclase) SL1344_1218(conserved hypothetical membrane protein) Cluster3357 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2019(hypothetical protein,Orthopoxvirus protein of unknown function (DUF830)) b1862(conserved protein, DUF830 family) t0980(conserved hypothetical protein) SL1344_1832(conserved hypothetical protein) Cluster3358 1 0 2 0 0 0 1 ROD_25951(putative phage capsid protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1956(Phage major capsid protein E),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2745(Phage major capsid protein E) SL1344_2567(predicted bacteriophage protein) Cluster3359 1 0 2 0 0 0 1 ROD_25981(hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1954(Protease 4,protease 4,signal peptide peptidase SppA, 36K type,Peptidase family S49),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2747(Probable protease sohB,putative inner membrane peptidase,signal peptide peptidase SppA, 36K type,Peptidase family S49) SL1344_2569(putative bacteriophage tail protein) Cluster3360 1 0 2 0 0 0 1 ROD_25991(putative phage portal protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1953(phage portal protein, lambda family,Phage portal protein, lambda family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2748(phage portal protein, lambda family,Phage portal protein, lambda family) SL1344_2570(predicted bacteriophage protein) Cluster3361 0 0 1 0 0 1 2 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1921(transcriptional repressor DicA,Helix-turn-helix) t1920(putative DNA-binding protein) SL1344_0950(predicted bacteriophage protein),SL1344_2593(putative DNA-binding protein) Cluster3362 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1887(Methyl viologen resistance protein C,multidrug efflux protein,Membrane transporters of cations and cationic drugs,Small Multidrug Resistance protein) b0543(DLP12 prophage; multidrug resistance protein) t1556(putative multidrug transporter) SL1344_1583(putative multidrug transporter) Cluster3363 0 0 3 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1843(Outer membrane protein X precursor,resistance to complement killing,Opacity protein and related surface antigens,Enterobacterial Ail/Lom protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2527(Outer membrane protein X precursor,outer membrane protein X,Opacity protein and related surface antigens,Enterobacterial Ail/Lom protein),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.8(Outer membrane protein X precursor,resistance to complement killing,Opacity protein and related surface antigens,Enterobacterial Ail/Lom protein) pseudob4570(unknown) Cluster3364 0 0 2 2 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.173(Glutamate decarboxylase alpha,L-tyrosine decarboxylase,glutamate decarboxylase,Pyridoxal-dependent decarboxylase conserved domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2343(Glutamate decarboxylase beta,L-tyrosine decarboxylase,glutamate decarboxylase,Pyridoxal-dependent decarboxylase conserved domain) b1493(glutamate decarboxylase B, PLP-dependent),b3517(glutamate decarboxylase A, PLP-dependent) Cluster3365 1 0 2 1 0 0 0 ROD_49651(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1708(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4123(hypothetical protein) pseudob2006(unknown) Cluster3366 1 0 1 1 0 0 1 ROD_47501(putative tagatose 6-phosphate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1619(D-tagatose-1,6-bisphosphate aldolase subunit gatZ,D-tagatose-1,6-bisphosphate aldolase subunit GatZ,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit,Tagatose 6 phosphate kinase) b2095(D-tagatose 1,6-bisphosphate aldolase 2, subunit) SL1344_3230(putative sugar kinase) Cluster3367 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1598(Protein of unknown function (DUF2574)) b2112(predicted protein) t0703(conserved hypothetical protein) SL1344_2130(conserved hypothetical protein) Cluster3368 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1586(Uncharacterized lipoprotein yehR precursor,Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF1307)) b2123(lipoprotein, DUF1307 family) t0700(putative lipoprotein) SL1344_2133(putative lipoprotein) Cluster3369 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1563(NAD-dependent dihydropyrimidine dehydrogenase sunbunit PreT,dihydropyrimidine dehydrogenase subunit A,Protoporphyrinogen oxidase,glutamate synthase (NADPH), homotetrameric,Pyridine nucleotide-disulphide oxidoreductase) b2146(Dihydropyrimidine dehydrogenase, NADH-dependent, subunit A) t0669(putative oxidoreductase) SL1344_2163(putative oxidoreductase) Cluster3370 0 0 2 1 0 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.147(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.151(hypothetical protein) b4453(toxic polypeptide, small) t3891(hypothetical protein) Cluster3371 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1378(Fimbrial subunit ElfA precursor,putative minor fimbrial subunit StfG,P pilus assembly protein, pilin FimA,Fimbrial protein) b2333(predicted fimbrial-like adhesin protein) t2861(fimbrial subunit) SL1344_0201(putative minor fimbrial subunit) Cluster3372 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1377(putative minor fimbrial subunit StfF,P pilus assembly protein, pilin FimA) b2334(predicted fimbrial-like adhesin protein) t2860(fimbrial subunit) SL1344_0200(minor fimbrial subunit stff) Cluster3373 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1376(putative minor fimbrial subunit StfE,P pilus assembly protein, pilin FimA) b2335(predicted fimbrial-like adhesin protein) t2859(fimbrial subunit) SL1344_0199(minor fimbrial subunit stfe (putaive minor fimbrial subunit)) Cluster3374 1 0 1 1 0 0 1 ROD_34961(putative major fimbrial subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1373(Major MR/P fimbria protein precursor,putative fimbrial subunit StfA,P pilus assembly protein, pilin FimA,Fimbrial protein) b2339(predicted fimbrial-like adhesin protein) SL1344_0196(major fimbrial subunit stfa (putative fimbrial subunit)) Cluster3375 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1339(Protein of unknown function (DUF2545)) b2377(predicted inner membrane protein) t0458(conserved hypothetical protein) SL1344_2368(conserved hypothetical protein) Cluster3376 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1314(Hca operon transcriptional activator,DNA-binding transcriptional activator XapR,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b2405(DNA-binding transcriptional activator for for xapAB) t0437(xanthosine operon transcriptional regulator) SL1344_2382(xanthosine operon transcriptional regulator) Cluster3377 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1313(Xanthosine transporter,galactoside permease,nucleoside transporter,Nucleoside H+ symporter) b2406(xanthosine transporter) t0436(xanthosine permease) SL1344_2384(xanthosine permease) Cluster3378 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1312(Xanthosine phosphorylase,purine nucleoside phosphorylase,Purine nucleoside phosphorylase,xanthosine phosphorylase,Phosphorylase superfamily) b2407(purine nucleoside phosphorylase II) t0435(xanthosine phosphorylase) SL1344_2385(xanthosine phosphorylase) Cluster3379 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1311(hypothetical protein,Nucleoside-specific channel-forming protein, Tsx) b2408(predicted outer membrane protein) t0434(conserved hypothetical protein) SL1344_2386(conserved hypothetical protein) Cluster3380 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1299(hypothetical protein) b2419(predicted protein) t0419(putative exported protein) SL1344_2401(putative exported protein) Cluster3381 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1201(hypothetical protein,Predicted esterase,Alpha/beta hydrolase family) b2534(S9 peptidase family protein, function unknown) t0309(putative membrane protein) SL1344_2509(putative membrane protein) Cluster3382 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.111(Electron transport protein hydN,formate dehydrogenase-H ferredoxin subunit,Uncharacterized Fe-S center protein,dimethylsulfoxide reductase, chain B,4Fe-4S binding domain) b3573(predicted hydrogenase, 4Fe-4S ferredoxin-type component) t3853(putative electron-transport protein) SL1344_3631(putative electron-transport protein) Cluster3383 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.106(2,3-diketo-L-gulonate TRAP transporter small permease protein yiaM,2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM,TRAP-type C4-dicarboxylate transport system, small permease component,Tripartite ATP-independent periplasmic transporters, DctQ component) b3577(L-dehydroascorbate transporter, TRAP permease small subunit for TRAP (TRipartite ATP-independent Periplasmic) family transporter YiaMNO) t3848(putative membrane protein) SL1344_3636(putative membrane protein) Cluster3384 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.105(Neu5Ac permease,L-dehydroascorbate transporter large permease subunit,TRAP-type C4-dicarboxylate transport system, small permease component,TRAP transporter, DctM subunit,DctM-like transporters) b3578(L-dehydroascorbate transporter, TRAP permease large subunit for TRAP (TRipartite ATP-independent Periplasmic) family transporter YiaMNO) t3847(putative membrane protein) SL1344_3637(putative membrane protein) Cluster3385 0 0 1 1 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1041(Serine/threonine-protein phosphatase 2,serine/threonine-specific protein phosphatase 2,Predicted kinase,bis(5'-nucleosyl)-tetraphosphatase (symmetrical),Calcineurin-like phosphoesterase) b2734(serine/threonine-specific protein phosphatase 2) t2807(possible serine/threonine protein phosphatase) SL1344_2886(possible serine/threonine protein phosphatase) Cluster3386 0 1 1 0 0 1 1 ENC_47460(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.107(hypothetical protein) t3849(hypothetical protein) SL1344_3635(hypothetical protein) Cluster3387 0 1 1 1 0 1 0 ENC_46500(P pilus assembly protein, pilin FimA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3845(putative fimbrial protein StaD,P pilus assembly protein, pilin FimA) b0138(predicted fimbrial-like adhesin protein) t0187(putative fimbrial protein) Cluster3388 0 1 1 1 0 1 0 ENC_46490(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3846(putative fimbrial protein StaE,P pilus assembly protein, pilin FimA) b0137(predicted fimbrial-like adhesin protein) t0186(putative fimbrial protein) Cluster3389 0 1 1 1 0 1 0 ENC_46480(P pilus assembly protein, pilin FimA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3847(hypothetical protein,putative fimbrial protein StaF,P pilus assembly protein, pilin FimA) b0136(predicted fimbrial-like adhesin protein) t0185(putative fimbrial protein) Cluster3390 1 1 0 0 0 1 1 ROD_00291(putative PTS system protein) ENC_45510(Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC) t3749(putative PTS system protein) SL1344_3735(putative PTS system protein) Cluster3391 1 1 0 0 0 1 1 ROD_00281(putative PTS system protein) ENC_45500(PTS system IID component, Man family (TC 4.A.6)) t3748(putative PTS system protein) SL1344_3734(putative PTS system protein) Cluster3392 0 1 1 0 0 1 1 ENC_44500(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4049(Protein of unknown function (DUF497)) t4578(hypothetical protein) SL1344_4459(hypothetical protein) Cluster3393 1 1 0 0 0 1 1 ROD_29411(hypothetical protein) ENC_44130(HSP20-like domain of unknown function (DUF1813).) t2563(hypothetical protein) pseudoSL1344_0292(conserved hypothetical protein (SPI-6 associated)) Cluster3394 1 1 0 0 0 1 1 ROD_33181(putative transcriptional regulator) ENC_43740(transcriptional regulator, ArgR family) t4497(putative transcriptional regulator) SL1344_4393(putative transcriptional regulator) Cluster3395 1 1 0 0 0 1 1 ROD_32121(transcriptional regulatory protein EntR (Entericidin R)) ENC_42490(Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain) t4389(transcriptional regulatory protein) SL1344_4274(transcriptional regulatory protein) Cluster3396 0 1 1 0 0 1 1 ENC_40570(YadA-like C-terminal region.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.82(Adhesin yadA precursor,Haemagglutinin) t3828(putative autotransporter) SL1344_3656(putative inner membrane protein) Cluster3397 1 1 0 0 0 1 1 ROD_31491(putative two-component system sensor kinase) ENC_39510(Signal transduction histidine kinase) t2678(putative two-component system sensor kinase) SL1344_2768(putative two-component system sensor kinase) Cluster3398 1 1 0 0 0 1 1 ROD_31481(transcriptional regulator) ENC_39500(transcriptional regulator) t2679(transcriptional regulator) SL1344_2769(transcriptional regulator) Cluster3399 1 1 0 0 0 1 1 ROD_31461(putative membrane protein) ENC_39480(hypothetical protein) t2682(putative membrane protein) SL1344_2771(putative membrane protein) Cluster3400 1 1 0 0 0 1 1 ROD_26761(putative chemotaxis signal transduction protein) ENC_39360(Chemotaxis signal transduction protein) t0549(putative receptor/regulator protein) SL1344_2283(putative receptor/regulator protein) Cluster3401 1 1 0 0 0 1 1 ROD_27011(putative transketolase C-terminal section) ENC_39130(transketolase subunit B) t0524(putative transketolase C-terminal section) SL1344_2309(putative transketolase C-terminal section) Cluster3402 1 1 0 0 0 1 1 ROD_27021(putative transketolase N-terminal section) ENC_39120(transketolase subunit A) t0523(putative transketolase N-terminal section) SL1344_2310(putative transketolase N-terminal section) Cluster3403 1 1 0 0 0 1 1 ROD_34431(putative polyferredoxin) ENC_37430(hypothetical protein) t0329(putative polyferredoxin) SL1344_2489(putative polyferredoxin) Cluster3404 1 1 0 0 0 1 1 ROD_34421(putative anaerobic reductase component) ENC_37420(DMSO reductase anchor subunit) t0328(putative anaerobic reductase component) SL1344_2490(putative anaerobic reductase component) Cluster3405 1 1 0 0 0 1 1 ROD_34411(putative anaerobic reductase component) ENC_37410(DMSO reductase, iron-sulfur subunit) t0327(putative anaerobic reductase component) SL1344_2491(putative anaerobic reductase component) Cluster3406 1 1 0 0 0 1 1 ROD_25051(N-acetylmuramic acid-specific PTS system EIIBC component) ENC_37020(PTS system IIB component, Glc family (TC 4.A.1)/PTS system IIC component, Glc family (TC 4.A.1)) t0287(putative IIBC component of PTS system) SL1344_2532(putative PTS system IIBC component) Cluster3407 2 1 1 0 0 0 0 ROD_02631(putative prophage DNA adenine methylase),ROD_19791(putative prophage DNA adenine methylase) ENC_35770(DNA modification methylase) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.122(DNA adenine methyltransferase YhdJ,putative methylase,Adenine specific DNA methylase Mod,DNA methylase) Cluster3408 0 1 1 0 0 1 1 ENC_35300(putative addiction module antidote protein, CC2985 family) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.147(Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain,putative addiction module antidote protein, CC2985 family,Uncharacterised protein family (UPF0156)) t2864(hypothetical protein) SL1344_2936(conserved hypothetical protein) Cluster3409 0 1 0 1 0 1 1 ENC_33320(P pilus assembly protein, chaperone PapD) b0944(predicted periplasmic pilini chaperone) t0028(fimbrial chaperone) SL1344_0027(fimbrial chaperone) Cluster3410 0 1 0 1 0 1 1 ENC_33300(P pilus assembly protein, pilin FimA) b0942(predicted fimbrial-like adhesin protein) t0026(fimbrial subunit) SL1344_0025(fimbrial subunit) Cluster3411 0 1 0 1 0 1 1 ENC_33250(P pilus assembly protein, pilin FimA) b0938(predicted fimbrial-like adhesin protein) t0022(fimbrial subunit) SL1344_0021(fimbrial subunit) Cluster3412 0 1 1 1 0 0 1 ENC_30820(Chain length determinant protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3411(Ferric enterobactin transport protein fepE,LPS O-antigen length regulator,Chain length determinant protein) b0587(regulator of length of O-antigen component of lipopolysaccharide chains) SL1344_0577(ferric enterobactin transport protein) Cluster3413 1 1 0 0 0 1 1 ROD_09691(putative DNA binding protein) ENC_30210(Transcriptional regulators) t1794(putative transcriptional regulator) SL1344_1065(putative transcriptional regulator) Cluster3414 1 1 0 0 0 1 1 ROD_25711(putative outer membrane efflux protein of T1SS) ENC_28990(type I secretion outer membrane protein, TolC family) t2644(putative type I secretion protein) SL1344_2662(putative type I secretion protein) Cluster3415 1 1 0 0 0 1 1 pseudoROD_42901(conserved hypothetical protein (pseudogene)) ENC_27130(hypothetical protein) t3913(putative membrane protein) SL1344_3569(putative membrane protein) Cluster3416 1 1 1 0 0 0 1 ROD_43491(2,3-diketo-L-gulonate TRAP transporter, substrate-binding periplasmic protein) ENC_26640(tripartite ATP-independent periplasmic transporter solute receptor, DctP family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.688(hypothetical protein,TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component,TRAP transporter solute receptor, DctP family,Bacterial extracellular solute-binding protein, family 7) SL1344_3143(putative membrane transport protein (periplasmic component)) Cluster3417 1 1 1 1 0 0 0 ROD_43911(putative membrane protein) ENC_26280(Multiple antibiotic transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.266(hypothetical protein,putative antibiotic transporter,membrane protein, MarC family,MarC family integral membrane protein) b3434(predicted antibiotic transporter) Cluster3418 1 1 1 1 0 0 0 ROD_10411(putative phage lysozyme) ENC_24150(Phage-related lysozyme (muraminidase)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1820(Phage-related lysozyme (muraminidase),Phage lysozyme) b1554(Qin prophage; predicted lysozyme) Cluster3419 0 1 0 1 0 1 1 ENC_22120(P pilus assembly protein, pilin FimA) b0534(predicted fimbrial-like adhesin protein) t2315(fimbria-like protein FimF precursor) SL1344_0541(putative fimbrial protein in fimZ 5' region) Cluster3420 1 1 1 1 0 0 0 ROD_27971(AraC-family transcriptional regulator) ENC_21040(transcriptional regulator, AraC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1334(Uncharacterized HTH-type transcriptional regulator ypdC,DNA-binding transcriptional regulator AraC,DNA gyrase inhibitor,YSIRK-targeted surface antigen transcriptional regulator,Helix-turn-helix domain) b2382(predicted DNA-binding protein) Cluster3421 1 1 1 1 0 0 0 ROD_28031(aminopeptidase) ENC_21010(Xaa-Pro aminopeptidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1331(Uncharacterized peptidase SA1530,aminopeptidase,Xaa-Pro aminopeptidase,methionine aminopeptidase, type I,Metallopeptidase family M24) b2385(Xaa-Pro aminopeptidase) Cluster3422 1 1 1 1 0 0 0 ROD_28041(fructose-like specific PTS system EIIC component 1) ENC_21000(PTS system, fructose subfamily, IIC component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1330(PTS system fructose-like EIIC component 1,putative PTS system fructose-like transporter subunit EIIC,PTS system, Fru family, IIC component,Phosphotransferase system, EIIC) b2386(predicted enzyme IIC component of PTS) Cluster3423 1 1 1 1 0 0 0 ROD_28051(fructose-like specific PTS system EIIB component 1) ENC_20990(PTS system, fructose-specific, IIB component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1329(Fructose-like phosphotransferase enzyme IIB component 1,putative PTS system fructose-like transporter subunit EIIB,PTS system, Fru family, IIB component,PTS system, Lactose/Cellobiose specific IIB subunit) b2387(predicted enzyme IIB component of PTS) Cluster3424 1 1 0 0 0 1 1 ROD_00151(putative polysaccharide degrading enzyme) ENC_18220(chitinase family 18) t0018(putative chitinase) SL1344_0018(putative chitinase) Cluster3425 1 1 1 1 0 0 0 ROD_09981(outer membrane protein F) ENC_17520(Outer membrane protein (porin)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2964(Porin OmpF,outer membrane protein F,Outer membrane protein (porin),Gram-negative porin) b0929(outer membrane porin 1a (Ia;b;F)) Cluster3426 0 1 1 0 0 0 2 ENC_17070(Phage-related protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2736(Phage-related protein,Phage minor tail protein) SL1344_0981(Minor Tail Component),SL1344_2557(predicted bacteriophage protein) Cluster3427 0 1 2 0 0 0 1 ENC_17050(Predicted metal-dependent protease of the PAD1/JAB1 superfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1840(NlpC/P60 family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2530(NlpC/P60 family) SL1344_2555(predicted bacteriophage protein) Cluster3428 0 1 2 0 0 0 1 ENC_17040(Phage-related protein, tail component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1841(Phage-related protein, tail component,Bacteriophage lambda tail assembly protein I),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2733(Phage-related protein, tail component,Bacteriophage lambda tail assembly protein I) SL1344_2554(predicted bacteriophage protein) Cluster3429 1 1 1 1 0 0 0 ROD_11821(putative acyltransferase) ENC_15230(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2801(Inner membrane protein YcfT,glucans biosynthesis protein,Predicted membrane protein,Acyltransferase family) b1115(inner membrane protein) Cluster3430 0 1 1 1 0 1 0 ENC_15100(Transposase and inactivated derivatives) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3755(Transposase and inactivated derivatives) b0228(conserved protein) t4614(conserved hypothetical protein) Cluster3431 1 1 0 0 0 1 1 ROD_12601(conserved hypothetical protein) ENC_14910(hypothetical protein) t1156(hypothetical protein) SL1344_1212(hypothetical protein) Cluster3432 0 1 0 1 0 1 1 ENC_14650(Beta-lactamase class C and other penicillin binding proteins) b2430(weak penicillin binding protein PBP4B, predicted periplasmic esterase) t0381(putative exported protein) SL1344_2441(putative exported protein) Cluster3433 1 1 0 0 0 1 1 ROD_13761(putative ABC transporter ATP-binding protein) ENC_13580(ABC-type metal ion transport system, ATPase component) t2349(ABC transporter ATP-binding protein) SL1344_0504(ABC transporter ATP-binding protein) Cluster3434 1 1 0 0 0 1 1 pseudoROD_43081(putative exported protein (pseudogene)) ENC_13490(Domain of unknown function (DUF1996).) t4216(putative exported protein) SL1344_4246(putative exported protein) Cluster3435 1 1 0 0 0 1 1 ROD_13971(putative membrane protein) ENC_12680(Small-conductance mechanosensitive channel) t1138(putative membrane protein) SL1344_1196(putative membrane protein) Cluster3436 1 1 0 0 0 1 1 ROD_14731(putative ABC transporter ATP-binding protein) ENC_12280(glycine betaine/L-proline transport ATP binding subunit) t1412(putative ABC transporter ATP/GTP-binding protein) SL1344_1421(putative ABC transporter ATP/GTP-binding protein) Cluster3437 1 1 0 0 0 1 1 ROD_14741(putative ABC transporter membrane protein) ENC_12270(ABC-type proline/glycine betaine transport systems, permease component) t1413(putative ABC transporter membrane protein) SL1344_1422(putative ABC transporter membrane protein) Cluster3438 1 1 0 0 0 1 1 ROD_14751(putative ABC transporter periplasmic binding protein) ENC_12260(Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)) t1414(putative ABC transporter periplasmic binding protein) SL1344_1423(putative ABC transporter periplasmic binding protein) Cluster3439 1 1 0 0 0 1 1 ROD_14761(putative ABC transporter membrane protein) ENC_12250(ABC-type proline/glycine betaine transport systems, permease component) t1415(putative ABC transporter membrane protein) SL1344_1424(putative ABC transporter membrane protein) Cluster3440 1 1 0 0 0 1 1 ROD_15441(putative hydrolase) ENC_10340(maltooligosyl trehalose hydrolase) t1473(putative hydrolase) SL1344_1490(putative hydrolase) Cluster3441 0 1 0 1 0 1 1 ENC_10100(D-alanyl-D-alanine dipeptidase) b1488(D-ala-D-ala dipeptidase, Zn-dependent) t1508(D-alanyl-D-alanine dipeptidase) SL1344_1530(D-alanyl-D-alanine dipeptidase) Cluster3442 1 1 0 1 0 0 1 ROD_15641(outer membrane porin protein) ENC_09800(Outer membrane protein (porin)) pseudob0553(unknown) SL1344_1503(outer membrane protein) Cluster3443 1 1 0 0 0 1 1 ROD_15871(putative virulence effector protein) ENC_09380(Uncharacterized protein conserved in bacteria, putative virulence factor) t1504(putative virulence effector protein) SL1344_1525(putative virulence effector protein) Cluster3444 1 1 0 0 0 1 1 ROD_15881(putative virulence effector protein) ENC_09370(Uncharacterized protein conserved in bacteria, putative virulence factor) t1505(putative virulence effector protein) SL1344_1526(putative virulence effector protein) Cluster3445 1 1 1 1 0 0 0 ROD_16891(putative LacI-family transcriptional regulator) ENC_08810(Transcriptional regulators) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2446(Catabolite control protein,DNA-binding transcriptional repressor PurR,ABC-type sugar transport system, periplasmic component,catabolite control protein A,Periplasmic binding proteins and sugar binding domain of LacI family) b1320(predicted DNA-binding transcriptional regulator) Cluster3446 1 1 1 1 0 0 0 pseudoROD_16911(putative sugar ABC transporter, ATP-binding protein (pseudogene)) ENC_08790(carbohydrate ABC transporter ATP-binding protein, CUT1 family (TC 3.A.1.1.-)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2448(sn-glycerol-3-phosphate import ATP-binding protein UgpC,glycerol-3-phosphate transporter ATP-binding subunit,ABC-type spermidine/putrescine transport systems, ATPase components,putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein,ABC transporter) pseudob4524(unknown) Cluster3447 1 1 1 1 0 0 0 ROD_16921(putative beta-phosphoglucomutase) ENC_08780(beta-phosphoglucomutase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2449(Putative beta-phosphoglucomutase,2-deoxyglucose-6-phosphatase,beta-p hosphoglucomutase,haloacid dehalogenase-like hydrolase) b1317(beta-phosphoglucomutase) Cluster3448 1 1 1 1 0 0 0 ROD_16931(putative glycosyl hydrolase) ENC_08770(Trehalose and maltose hydrolases (possible phosphorylases)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2450(Kojibiose phosphorylase,maltose phosphorylase,Trehalose and maltose hydrolases (possible phosphorylases),Glycosyl hydrolase family 65 central catalytic domain) b1316(predicted hydrolase) Cluster3449 1 1 1 1 0 0 0 ROD_16951(hydroxypyruvate isomerase) ENC_08750(Sugar phosphate isomerases/epimerases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2452(hypothetical protein,hydroxypyruvate isomerase,Hydroxypyruvate isomerase,hydroxypyruvate isomerase,Xylose isomerase-like TIM barrel) b1314(predicted enzyme) Cluster3450 1 1 1 1 0 0 0 ROD_16961(putative oxidoreductase) ENC_08740(Threonine dehydrogenase and related Zn-dependent dehydrogenases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2453(Sorbitol dehydrogenase,L-threonine 3-dehydrogenase,L-threonine 3-dehydrogenase,Zinc-binding dehydrogenase) b1313(predicted oxidoreductase, Zn-dependent and NAD(P)-binding) Cluster3451 1 1 1 1 0 0 0 ROD_16971(putative ABC transporter membrane protein) ENC_08730(carbohydrate ABC transporter membrane protein 2, CUT1 family (TC 3.A.1.1.-)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2454(Inner membrane ABC transporter permease protein ycjP,maltose transporter permease,ABC-type maltose transport systems, permease component,NifC-like ABC-type porter,Binding-protein-dependent transport system inner membrane component) b1312(predicted sugar transporter subunit: membrane component of ABC superfamily) Cluster3452 1 1 1 1 0 0 0 ROD_16981(putative ABC transporter membrane protein) ENC_08720(carbohydrate ABC transporter membrane protein 1, CUT1 family (TC 3.A.1.1.-)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2455(Inner membrane ABC transporter permease protein ycjO,glycerol-3-phosphate transporter permease,ABC-type polysaccharide transport system, permease component,putative 2-aminoethylphosphonate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component) b1311(predicted sugar transporter subunit: membrane component of ABC superfamily) Cluster3453 1 1 1 1 0 0 0 ROD_16991(putative ABC transporter periplasmic binding protein) ENC_08710(carbohydrate ABC transporter substrate-binding protein, CUT1 family (TC 3.A.1.1.-)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2456(glycerol-3-phosphate transporter periplasmic binding protein,ABC-type thiamine transport system, periplasmic component,Bacterial extracellular solute-binding protein) b1310(predicted sugar transporter subunit: periplasmic-binding component of ABC superfamily) Cluster3454 0 1 1 1 0 0 1 ENC_08570(Putative translation initiation inhibitor, yjgF family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4203(RutC family protein yjgH,putative endoribonuclease L-PSP,putative endoribonuclease L-PSP,Endoribonuclease L-PSP) b4248(conserved protein, UPF0131 family) SL1344_1478(conserved hypothetical protein) Cluster3455 1 1 1 1 0 0 0 ROD_17261(hypothetical protein) ENC_08360(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2490(hypothetical protein) b4523(hypothetical protein) Cluster3456 1 1 0 0 0 1 1 ROD_27671(VgrG family T6SS protein Cts1G) ENC_07420(type VI secretion system Vgr family protein) t2571(Rhs-family protein) SL1344_0284(Type VI secretion protein) Cluster3457 1 1 0 0 0 1 1 ROD_27831(T6SS protein Cts1R) ENC_07360(type VI secretion protein, VC_A0111 family) t2596(hypothetical protein) SL1344_0261(conserved hypothetical protein (SPI-6 associated)) Cluster3458 1 1 0 0 0 1 1 ROD_27821(T6SS protein Cts1C) ENC_07350(type VI secretion protein, VC_A0110 family) t2597(hypothetical protein) SL1344_0262(conserved hypothetical protein (SPI-6 associated)) Cluster3459 1 1 0 0 0 1 1 ROD_27641(T6SS lysozyme-related protein Cts1D) ENC_07340(type VI secretion system lysozyme-related protein) t2595(conserved hypothetical protein) SL1344_0263(conserved hypothetical protein (SPI-6 associated)) Cluster3460 1 1 0 0 0 1 1 ROD_27761(T6SS protein Cts1S) ENC_07240(type VI secretion protein, VC_A0107 family) t2588(conserved hypothetical protein) SL1344_0267(conserved hypothetical protein (SPI-6 associated)) Cluster3461 1 1 0 0 0 1 1 ROD_27711(T6SS protein Cts1U) ENC_07200(type IV / VI secretion system protein, DotU family) t2581(putative membrane protein) SL1344_0277(putative membrane protein (SPI-6 associated)) Cluster3462 1 1 0 0 0 1 1 ROD_27721(T6SS protein Cts1M) ENC_07190(type VI secretion protein, VC_A0114 family) t2582(conserved hypothetical protein) SL1344_0276(conserved hypothetical protein (SPI-6 associated)) Cluster3463 1 1 0 0 0 1 1 ROD_27731(T6SS protein Cts1N) ENC_07180(type VI secretion lipoprotein, VC_A0113 family) t2583(probable lipoprotein) SL1344_0275(lipoprotein (SPI-6 associated)) Cluster3464 1 1 0 0 0 1 1 ROD_19541(conserved hypothetical protein) ENC_05850(Putative intracellular protease/amidase) t0946(conserved hypothetical protein) SL1344_1864(conserved hypothetical protein) Cluster3465 1 1 1 1 0 0 0 ROD_34741(Allose utilisation regulator, AlsR) ENC_05230(Transcriptional regulators) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4376(Als operon repressor,DNA-binding transcriptional repressor RpiR,Predicted phosphosugar isomerases,6-phospho 3-hexuloisomerase,Helix-turn-helix domain, rpiR family) b4089(DNA-binding transcriptional repressor) Cluster3466 1 1 1 1 0 0 0 ROD_34731(D-allose transporter periplasmic binding protein) ENC_05220(allose-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4377(D-allose-binding periplasmic protein precursor,D-allose transporter subunit,ABC-type sugar transport system, periplasmic component,rhamnose ABC transporter, rhamnose-binding protein,Periplasmic binding proteins and sugar binding domain of LacI family) b4088(D-allose transporter subunit) Cluster3467 1 1 1 1 0 0 0 ROD_34721(D-allose transporter ATP-binding protein AlsA) ENC_05210(allose ABC transporter ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4378(Ribose import ATP-binding protein RbsA,D-allose transporter ATP-binding protein,ABC-type Na+ transport system, ATPase component,D-xylose ABC transporter, ATP-binding protein,ABC transporter) b4087(fused D-allose transporter subunits of ABC superfamily: ATP-binding components) Cluster3468 1 1 1 1 0 0 0 ROD_34691(D-allose kinase) ENC_05180(D-allose kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4381(D-allose kinase,D-allose kinase,ROK family protein (putative glucokinase),ROK family) b4084(D-allose kinase) Cluster3469 1 1 0 0 0 1 1 ROD_37241(putative exported protein) ENC_04570(Exopolysaccharide production protein YjbE.) t4128(putative exported protein) SL1344_4158(putative exported protein) Cluster3470 0 1 0 0 0 1 2 ENC_03110(Protein of unknown function (DUF1493).) t0866(hypothetical protein) SL1344_1987(conserved hypothetical protein),SL1344_2469(conserved hypothetical protein) Cluster3471 0 1 0 1 0 1 1 ENC_02940(Virulence protein) pseudob4653(unknown) t3764(putative DNA-binding protein) SL1344_3720(putative DNA-binding protein) Cluster3472 0 1 0 1 0 1 1 ENC_02930(HSP20-like domain of unknown function (DUF1813).) b4347(toxic peptide regulated by antisense sRNA symR) t4573(conserved hypothetical protein) SL1344_4454(endoribonuclease) Cluster3473 1 1 0 1 0 0 1 ROD_11781(putative fimbrial usher protein) ENC_00490(P pilus assembly protein, porin PapC) b3216(predicted outer membrane mbrial subunitusher protein) SL1344_4499(fimbrial usher protein) Cluster3474 1 1 0 1 0 0 1 ROD_11771(putative fimbrial chaperone protein) ENC_00480(P pilus assembly protein, chaperone PapD) b3215(predicted periplasmic chaperone protein) SL1344_4500(fimbrial chaperone) Cluster3475 1 1 0 1 0 0 1 ROD_38811(putative N-acylglucosamine 2-epimerase) ENC_00280(N-acyl-D-glucosamine 2-epimerase) b3880(aldose-ketose isomerase; D-mannose isomerase) SL1344_3967(conserved hypothetical protein) Cluster3476 0 1 1 1 1 0 0 ENC_36610(ABC-type Fe3+-citrate transport system, periplasmic component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4152(Putative ABC transporter substrate-binding lipoprotein yhfQ precursor,iron-dicitrate transporter substrate-binding subunit,ABC-type Fe3+-citrate transport system, periplasmic component,putative ABC transporter PGF-CTERM-modified substrate-binding protein,Periplasmic binding protein) b4290(KpLE2 phage-like element; iron-dicitrate transporter subunit) BN373_p02231(conserved hypothetical protein) Cluster3477 1 0 1 1 1 0 0 pseudoROD_34381(putative regulator for fec operon FecR (fragment)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4150(fec operon regulator FecR,FecR protein) b4292(KpLE2 phage-like element; transmembrane signal transducer for ferric citrate transport) BN373_p02211(fec operon regulator FecR) Cluster3478 0 1 0 0 1 1 1 ENC_19070(Glycosyl transferases, related to UDP-glucuronosyltransferase) BN373_p02151(IroB) t2668(putative glycosyl transferase) SL1344_2758(putative glycosyltransferase) Cluster3479 0 1 0 0 1 1 1 ENC_19090(Enterochelin esterase and related enzymes) BN373_p02131(IroD) t2670(putative ferric enterochelin esterase) SL1344_2760(putative ferric enterochelin esterase) Cluster3480 0 0 3 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.39(Transposase and inactivated derivatives, TnpA family,Tn3 transposase DDE domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.45(Transposase and inactivated derivatives, TnpA family,Tn3 transposase DDE domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.79(Transposase and inactivated derivatives, TnpA family,Tn3 transposase DDE domain) BN373_p00811(TnpA transposase) Cluster3481 0 2 0 0 1 1 0 ENC_35320(hypothetical protein),ENC_35540(hypothetical protein) BN373_p00571(SilE) t2302(possible copper-binding protein) Cluster3482 0 0 0 0 4 0 0 BN373_p00421(conserved hypothetical protein),BN373_p00441(conserved hypothetical protein),BN373_p00981(conserved hypothetical protein),BN373_p01051(CobW) Cluster3483 0 0 0 0 2 1 1 BN373_p00201(RmpA2),BN373_p02081(putative response regulator) t2514(possible transcriptionl regulator) SL1344_0342(possible transcriptionl regulator) Cluster3484 1 0 1 0 2 0 0 pseudoROD_40831(putative transposase (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4697(putative transposase,conserved hypothetical protein,Putative transposase, YhgA-like) BN373_49441(conserved hypothetical protein),BN373_p00501(putative transposase) Cluster3485 0 0 1 0 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4561(hypothetical protein) BN373_48681(conserved hypothetical protein) t3516(hypothetical protein) SL1344_4053(conserved hypothetical protein) Cluster3486 1 1 0 0 1 1 0 ROD_38681(conserved hypothetical protein) ENC_00390(Predicted nucleic acid-binding protein, contains PIN domain) BN373_48181(PIN domain protein) t3587(hypothetical protein) Cluster3487 1 1 0 1 1 0 0 ROD_40441(PTS system EIIBC component) ENC_03750(PTS system glucose/alpha-glucoside-specific IIB component, Glc family (TC 4.A.1.1.10)/PTS system glucose/alpha-glucoside-specific IIC component, Glc family (TC 4.A.1.1.10)) pseudob3683(unknown) BN373_47301(PTS system, alpha-glucoside-specific EIICB component) Cluster3488 1 1 0 0 1 0 1 ROD_40571(putative membrane protein) ENC_03660(EamA-like transporter family.) BN373_47211(putative membrane protein) SL1344_3765(putative membrane protein) Cluster3489 0 0 1 0 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4853(putative transcriptional regulator,putative zinc finger/helix-turn-helix protein, YgiT family,Helix-turn-helix) BN373_47111(helix-turn-helix DNA-binding domain protein) t3740(putative DNA-binding protein) SL1344_3744(putative DNA-binding protein) Cluster3490 0 0 0 1 1 1 1 b3872(predicted DNA-binding transcriptional regulator) BN373_47061(2-aminoethylphosphonate transporter repressor) t2433(probable 2-aminoethylphosphonate uptake and metabolism operon regulator) SL1344_0424(probable regulator of 2-aminoethylphosphonate uptake and metabolism operon) Cluster3491 0 1 1 1 1 0 0 ENC_14640(PTS system N-acetylmuramate-specific IIB component, Glc family (TC 4.A.1.2.7)/PTS system N-acetylmuramate-specific IIC component, Glc family (TC 4.A.1.2.7)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1291(EIIBC-MurNAc,PTS system N-acetylmuramic acid transporter subunits EIIBC,PTS system, sucrose-specific IIBC component,Phosphotransferase system, EIIC) b2429(N-acetylmuramic acid permease, EIIBC component, PTS system) BN373_46861(PTS system, N-acetylmuramic acid-specific EIIBC component) Cluster3492 1 0 1 1 1 0 0 ROD_03821(putative zinc-binding dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3640(Uncharacterized zinc-type alcohol dehydrogenase-like protein YahK,ethanol-active dehydrogenase/acetaldehyde-active reductase,Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase,NDMA-dependent alcohol dehydrogenase, Rxyl_3153 family,Zinc-binding dehydrogenase) b0325(predicted oxidoreductase, Zn-dependent and NAD(P)-binding) BN373_46671(oxidoreductase, zinc-binding dehydrogenase family) Cluster3493 1 1 0 0 1 0 1 ROD_38291(putative membrane protein) ENC_00800(Di-and tricarboxylate transporters) BN373_46481(sodium:sulfate symporter family protein) SL1344_4018(conserved hypothetical protein) Cluster3494 0 1 1 1 1 0 0 ENC_02440(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.63(O-antigen ligase,Lipid A core - O-antigen ligase and related enzymes) b3622(O-antigen ligase) BN373_46081(O-antigen polymerase) Cluster3495 0 1 1 1 1 0 0 ENC_47370(xylose ABC transporter membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.116(Xylose transport system permease protein xylH,ribose ABC transporter permease protein,Predicted ABC-type sugar transport system, permease component,urea ABC transporter, permease protein UrtC,Branched-chain amino acid transport system / permease component) b3568(D-xylose ABC transporter permease subunit) BN373_45751(D-xylose ABC transporter, permease protein) Cluster3496 0 1 1 1 1 0 0 ENC_47360(xylose ABC transporter ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.117(Xylose import ATP-binding protein XylG,xylose transporter ATP-binding subunit,Predicted periplasmic lipoprotein,D-xylose ABC transporter, ATP-binding protein,ABC transporter) b3567(fused D-xylose transporter subunits of ABC superfamily: ATP-binding components) BN373_45741(D-xylose ABC transporter, ATP-binding protein) Cluster3497 0 1 1 1 1 0 0 ENC_47350(xylose-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.118(D-xylose-binding periplasmic protein precursor,D-xylose transporter subunit XylF,ABC-type xylose transport system, periplasmic component,D-xylose ABC transporter, D-xylose-binding protein,Periplasmic binding proteins and sugar binding domain of LacI family) b3566(D-xylose transporter subunit) BN373_45731(D-xylose ABC transporter, periplasmic D-xylose-binding protein) Cluster3498 1 0 1 1 1 0 0 ROD_42431(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.121(Inner membrane protein yiaB,hypothetical protein,Predicted membrane protein,yiaA/B two helix domain) b3563(inner membrane protein, YiaAB family) BN373_45701(putative membrane protein) Cluster3499 0 0 0 0 2 1 1 BN373_45601(putative acetyltransferase),BN373_p00841(putative acetyltransferase) t3868(putative acetyltransferase) SL1344_3617(putative acetyltransferase) Cluster3500 1 1 0 1 1 0 0 ROD_42472(small toxic membrane protein HokA) ENC_45840(Hok/gef family.) b4455(toxic polypeptide, small) BN373_45571(protein HokA) Cluster3501 0 2 0 0 1 0 1 ENC_01630(Sugar phosphate permease),ENC_47470(Sugar phosphate permease) BN373_45501(transporter, major facilitator family) SL1344_3497(putative MFS-family membrane transport protein) Cluster3502 1 0 1 1 1 0 0 ROD_43171(nickel ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.221(Glutathione import ATP-binding protein GsiA,nickel transporter ATP-binding protein NikE,ABC-type oligopeptide transport system, ATPase component,nickel import ATP-binding protein NikE,ABC transporter) b3480(nickel transporter subunit) BN373_44891(nickel ABC transporter, ATP-binding protein NikE) Cluster3503 1 0 1 1 1 0 0 ROD_43181(nickel ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.222(Glutathione import ATP-binding protein GsiA,nickel transporter ATP-binding protein NikD,ABC-type oligopeptide transport system, ATPase component,nickel import ATP-binding protein NikD,ABC transporter) b3479(nickel transporter subunit) BN373_44881(nickel ABC transporter, ATP-binding protein NikD) Cluster3504 1 0 1 1 1 0 0 ROD_43191(nickel ABC transporter, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.223(Nickel transport system permease protein nikC,nickel transporter permease NikC,ABC-type antimicrobial peptide transport system, permease component,nickel ABC transporter, permease subunit NikC,Binding-protein-dependent transport system inner membrane component) b3478(nickel transporter subunit) BN373_44871(nickel ABC transporter, permease subunit NikC) Cluster3505 1 0 1 1 1 0 0 ROD_43201(nickel ABC-transporter, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.224(Nickel transport system permease protein nikB,nickel transporter permease NikB,nickel ABC transporter, permease subunit NikB,Binding-protein-dependent transport system inner membrane component) b3477(nickel transporter subunit) BN373_44861(nickel ABC transporter, permease protein NikB) Cluster3506 1 0 1 1 1 0 0 ROD_43211(nickel ABC transporter, substrate-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.225(Nickel-binding periplasmic protein precursor,glutathione ABC transporter substrate-binding protein GsiB,ABC-type oligopeptide transport system, periplasmic component,nickel ABC transporter, nickel/metallophore periplasmic binding protein,Bacterial extracellular solute-binding proteins, family 5 Middle) b3476(Nickel-binding, heme-binding periplasmic protein) BN373_44851(nickel ABC transporter, periplasmic nickel-binding protein NikA) Cluster3507 1 0 0 0 1 1 1 ROD_46071(Major Facilitator Superfamily transporter) BN373_42721(transporter, major facilitator family) t1462(membrane transport protein) SL1344_1472(membrane transport protein) Cluster3508 1 0 1 1 1 0 0 ROD_46821(putative permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.545(Predicted permease) b3151(predicted permease) BN373_42111(putative permease) Cluster3509 1 0 1 1 1 0 0 ROD_47971(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.600(Inner membrane protein ygjV,Bacterial inner membrane protein) b3090(inner membrane protein, Imp-YgjV family) BN373_41801(putative membrane protein) Cluster3510 0 1 0 0 1 1 1 ENC_33330(Cupin domain./Helix-turn-helix.) BN373_41751(cro/ci family transcriptional regulator) t1568(conserved hypothetical DNA-binding protein) SL1344_1595(conserved hypothetical DNA-binding protein) Cluster3511 0 1 0 0 1 1 1 ENC_33340(Uncharacterized conserved protein) BN373_41741(hypothetical protein) t1569(conserved hypothetical protein) SL1344_1596(conserved hypothetical protein) Cluster3512 0 0 0 1 1 1 1 b1517(putative autoinducer-2 (AI-2) aldolase) BN373_41651(lsrF protein) t3540(putative aldolase) SL1344_4027(putative aldolase) Cluster3513 0 0 0 1 1 1 1 b1518(autoinducer-2 (AI-2) degrading protein LsrG) BN373_41641(lsrG protein) t3539(conserved hypothetical protein) SL1344_4028(conserved hypothetical protein) Cluster3514 0 1 1 1 1 0 0 ENC_38130(Trehalase.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.613(hypothetical protein,alpha-glucosidase,Trehalase) b3080(alpha-glucosidase) BN373_41631(alpha-glucosidase) Cluster3515 0 1 1 1 1 0 0 ENC_38140(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.614(hypothetical protein) b3079(conserved protein) BN373_41621(conserved hypothetical protein) Cluster3516 0 1 1 1 1 0 0 ENC_38150(Amino acid transporters) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.615(Inner membrane transporter ygjI,inner membrane transporter YjeM,putative glutamate/gamma-aminobutyrate antiporter,Amino acid permease) b3078(predicted transporter) BN373_41611(amino acid permease-associated protein) Cluster3517 0 1 1 1 1 0 0 ENC_38160(Beta-galactosidase, beta subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.616(Evolved beta-galactosidase subunit beta,cryptic beta-D-galactosidase subunit beta,uncharacterized protein, YhcH/YjgK/YiaL family,Domain of unknown function (DUF386)) b3077(cryptic beta-D-galactosidase, beta subunit) BN373_41591(cryptic beta-D-galactosidase subunit beta) Cluster3518 0 1 1 1 1 0 0 ENC_38170(Beta-galactosidase/beta-glucuronidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.617(Evolved beta-galactosidase subunit alpha,cryptic beta-D-galactosidase subunit alpha,Glycosyl hydrolases family 2, TIM barrel domain) b3076(cryptic beta-D-galactosidase, alpha subunit) BN373_41581(cryptic beta-D-galactosidase subunit alpha) Cluster3519 0 1 1 1 1 0 0 ENC_38180(transcriptional regulator, LacI family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.618(Purine nucleotide synthesis repressor,DNA-binding transcriptional repressor EbgR,catabolite control protein A,Bacterial regulatory proteins, lacI family) b3075(DNA-binding transcriptional repressor) BN373_41571(DNA-binding transcriptional repressor EbgR) Cluster3520 1 0 1 1 1 0 0 ROD_03771(putative dihydroxyacetone kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2678(PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit dhaK,dihydroxyacetone kinase subunit DhaK,Transcriptional regulator, contains sigma factor-related N-terminal domain,dihydroxyacetone kinase, DhaK subunit,Dak1 domain) b1200(dihydroxyacetone kinase, PTS-dependent, dihydroxyacetone-binding subunit) BN373_41491(dihydroxyacetone kinase, DhaK subunit) Cluster3521 1 0 1 1 1 0 0 ROD_32071(putative reverse transcriptase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4902(Group II intron-encoded protein ltrA,Retron-type reverse transcriptase,Reverse transcriptase (RNA-dependent DNA polymerase)) pseudob0258(unknown) BN373_40571(conserved hypothetical protein) Cluster3522 0 0 0 1 1 1 1 b2939(predicted protein) BN373_40261(conserved hypothetical protein) t3000(conserved hypothetical protein) SL1344_3063(conserved hypothetical protein) Cluster3523 0 1 0 0 1 1 1 ENC_31390(hypothetical protein) BN373_39981(suppressor for copper-sensitivity A) t1807(membrane protein, suppressor for copper-sensitivity A) SL1344_1052(membrane protein, suppressor for copper-sensitivity A) Cluster3524 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3355(Sel1 repeat) b0644(conserved protein) BN373_39711(conserved hypothetical protein) SL1344_0642(conserved hypothetical protein) Cluster3525 1 1 0 0 2 0 0 ROD_36121(urease subunit alpha) ENC_33040(urease, alpha subunit) BN373_39581(urease subunit alpha),BN373_41211(urease, alpha subunit) Cluster3526 0 0 1 1 2 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.182(hypothetical protein,acid-resistance membrane protein,Uncharacterized conserved protein) b3511(acid-resistance membrane protein) BN373_39531(acid-resistance membrane protein),BN373_41361(putative HdeD protein) Cluster3527 1 0 0 0 1 1 1 ROD_29321(putative exported protein) BN373_39451(rtn-like protein) t2518(putative rtn protein) SL1344_0338(putative rtn protein) Cluster3528 0 1 1 1 1 0 0 ENC_35980(arsenate reductase (glutaredoxin)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.197(Arsenate reductase,arsenate reductase,Arsenate reductase and related proteins, glutaredoxin family,arsenate reductase (glutaredoxin),ArsC family) b3503(arsenate reductase) BN373_39351(arsenate reductase) Cluster3529 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2076(Domain of unknown function (DUF1889)) b1810(conserved protein, DUF1889 family) BN373_39331(conserved hypothetical protein) SL1344_0322(conserved hypothetical protein) Cluster3530 1 0 1 1 1 0 0 ROD_29181(fimbrial adhesin FimH) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4077(hypothetical protein,fimbrial chaperone protein,P pilus assembly protein, pilin FimA,FimH, mannose binding) b4320(minor component of type 1 fimbriae) BN373_39251(fimbrial protein FimH) Cluster3531 1 0 1 1 1 0 0 ROD_29111(fimbrial regulatory protein FimE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4084(Tyrosine recombinase XerC,tyrosine recombinase,Site-specific recombinase XerD,tyrosine recombinase XerD,Phage integrase family) b4313(tyrosine recombinase/inversion of on/off regulator of fimA) BN373_39181(tyrosine recombinase) Cluster3532 0 1 1 1 1 0 0 ENC_12570(Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2405(Putative oxidoreductase YdbC,putative oxidoreductase,Predicted oxidoreductase,voltage-dependent potassium channel beta subunit,Aldo/keto reductase family) b1406(predicted oxidoreductase, NAD(P)-binding) BN373_39031(oxidoreductase, aldo/keto reductase family) Cluster3533 0 1 0 0 1 1 1 ENC_30950(Predicted membrane protein) BN373_39011(putative membrane protein) t2931(conserved hypothetical protein) SL1344_2999(conserved hypothetical protein) Cluster3534 0 1 0 0 1 1 1 ENC_30940(Transcriptional regulator) BN373_39001(transcriptional regulator, LysR family) t2930(possible regulatory protein) SL1344_2998(possible regulatory protein) Cluster3535 0 1 0 0 1 1 1 ENC_30770(transcriptional regulator, LacI family) BN373_38821(sugar binding transcriptional regulator, LacI family) t2922(possible regulatory protein) SL1344_2990(possible regulatory protein) Cluster3536 1 2 0 0 1 0 0 ROD_37181(PTS system, cellobiose-specific IIc component) ENC_18990(PTS system, lactose/cellobiose family IIC component),ENC_30760(PTS system, lactose/cellobiose family IIC component) BN373_38811(PTS system, lactose/cellobiose family IIC component) Cluster3537 1 0 0 0 1 1 1 ROD_06581(Threonine-phosphate decarboxylase) BN373_38541(L-threonine-O-3-phosphate decarboxylase) t2223(putative aminotransferase CobD) SL1344_0632(putative aminotransferase CobD) Cluster3538 1 0 0 0 1 1 1 ROD_21441(propanediol utilization protein PduX) BN373_38531(propanediol utilization protein PduX) t0816(conserved hypothetical protein) SL1344_2034(putative propanediol utilization protein) Cluster3539 1 0 0 0 1 1 1 ROD_21431(propanediol utilization: propionate kinase) BN373_38521(propionate kinase, PduW) t0817(putative propionate kinase) SL1344_2033(Acetokinase) Cluster3540 1 0 0 0 1 1 1 ROD_21411(propanediol utilization protein PduU) BN373_38501(propanediol utilization protein pduU) t0819(putative propanediol utilization protein PduU) SL1344_2031(putative propanediol utilization protein PduU) Cluster3541 1 0 0 0 1 1 1 ROD_21401(propanediol utilization protein PduT) BN373_38491(propanediol utilization protein PduT) t0820(putative propanediol utilization protein PduT) SL1344_2030(putative propanediol utilization protein) Cluster3542 1 0 0 0 1 1 1 ROD_21391(propanediol utilization: polyhedral bodies) BN373_38481(propanediol utilization protein PduS) t0821(putative ferredoxin) SL1344_2029(propanediol utilization ferredoxin) Cluster3543 1 0 0 0 1 1 1 ROD_21381(propanediol utilization: propanol dehydrogenase) BN373_38471(propanediol utilization protein PduQ) t0822(putative propanol dehydrogenase) SL1344_2028(putative propanol dehydrogenase) Cluster3544 1 0 0 0 1 1 1 ROD_21371(propanediol utilization: CoA-dependent propionaldehyde dehydrogenase) BN373_38461(propanediol utilization protein PduP) t0823(putative CoA-dependent proprionaldehyde dehydrogenase) SL1344_2027(putative CoA-dependent proprionaldehyde dehydrogenase) Cluster3545 1 0 0 0 1 1 1 ROD_21361(propanediol utilization: B12 related) BN373_38451(propanediol utilization protein, PduO) t0824(conserved hypothetical protein) SL1344_2026(propanediol utilization protein) Cluster3546 1 0 0 0 1 1 1 ROD_21341(propanediol utilization protein) BN373_38431(propanediol utilization protein PduM) t0826(conserved hypothetical protein) SL1344_2024(propanediol utilization protein) Cluster3547 1 0 0 0 1 1 1 ROD_21331(propanediol utilization protein) BN373_38421(propanediol utilization protein PduL) t0827(conserved hypothetical protein) SL1344_2023(propanediol utilization protein) Cluster3548 1 0 0 0 1 1 1 ROD_21321(propanediol utilization protein PduK) BN373_38411(putative propanediol utilization protein) t0828(putative propanediol utilization protein PduK) SL1344_2022(propanediol utilization protein) Cluster3549 1 0 0 0 1 1 1 ROD_21311(propanediol utilization protein) BN373_38401(propanediol utilization protein PduJ) t0829(putative propanediol utilization protein PduJ) SL1344_2021(propanediol utilization protein) Cluster3550 1 0 0 0 1 1 1 ROD_21301(propanediol utilization: diol dehydratase reactivation) BN373_38391(propanediol utilization protein PduH) t0830(PduH protein) SL1344_2020(Propanediol utilization protein) Cluster3551 1 0 0 0 1 1 1 ROD_21281(propanediol utilization dehydratase, small subunit) BN373_38371(propanediol utilization dehydratase, small subunit) t0832(diol dehydratase small subunit) SL1344_2018(diol dehydratase small subunit) Cluster3552 1 0 0 0 1 1 1 ROD_21271(propanediol utilization dehydratase, medium subunit) BN373_38361(propanediol utilization dehydratase, medium subunit) t0833(diol dehydratase medium subunit) SL1344_2017(diol dehydratase medium subunit) Cluster3553 1 0 0 0 1 1 1 ROD_21251(propanediol utilization protein PduB) BN373_38341(propanediol utilization protein PduB) t0835(putative propanediol utilization protein PduB) SL1344_2015(putative propanediol utilization protein PduB) Cluster3554 1 0 0 0 1 1 1 ROD_21241(propanediol utilisation protein PduA) BN373_38331(propanediol utilization protein PduA) t0836(putative propanediol utilization protein PduA) SL1344_2014(putative propanediol utilization protein) Cluster3555 1 0 0 0 1 1 1 ROD_21221(propanediol diffusion facilitator) BN373_38321(propanediol diffusion facilitator) t0837(propanediol diffusion facilitator) SL1344_2013(putative propanediol diffusion facilitator) Cluster3556 1 0 0 0 1 1 1 ROD_21211(pdu/cob regulatory protein pocR) BN373_38311(regulatory protein PocR) t0838(pdu/cob regulatory protein PocR) SL1344_2012(pdu/cob regulatory protein PocR) Cluster3557 1 0 0 0 1 1 1 ROD_21201(cobyrinic acid A,C-diamide synthase) BN373_38301(cobyrinic acid a,c-diamide synthase) t0840(cobyrinic acid A,C-diamide synthase) SL1344_2011(Cobyrinic acid A,C-diamide synthase) Cluster3558 1 0 0 0 1 1 1 ROD_21191(cobalamin biosynthesis protein CbiB) BN373_38291(cobalamin biosynthesis protein CbiB) t0839(CbiB protein) SL1344_2010(Cobalamin biosynthesis protein) Cluster3559 1 0 0 0 1 1 1 ROD_21171(putative cobalt-precorrin-6A synthase [deacetylating]) BN373_38271(cobalamin biosynthesis protein CbiD) t0842(CbiD protein) SL1344_2008(Putative cobalt-precorrin-6A synthase [deacetylating]) Cluster3560 1 0 0 0 1 1 1 ROD_21161(probable cobalt-precorrin-6Y C(5)-methyltransferase (Cobalt-precorrin-6 methyltransferase) (Cobalt-precorrin-6Y methylase)) BN373_38261(precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit) t0843(precorrin-6Y C5,15-methyltransferase (decarboxylating)) SL1344_2007(precorrin-6Y C5,15-methyltransferase [decarboxylating]) Cluster3561 1 0 0 0 1 1 1 ROD_21151(probable cobalt-precorrin-6Y C(15)-methyltransferase [decarboxylating]) BN373_38251(precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit) t0844(precorrin-8W decarboxylase) SL1344_2006(precorrin-8W decarboxylase) Cluster3562 1 0 0 0 1 1 1 ROD_21141(cobalt-precorrin-4 C(11)-methyltransferase (Cobalt-precorrin-3 methylase)) BN373_38241(precorrin-4 C11-methyltransferase) t0845(precorrin-4 C11-methyltransferase) SL1344_2005(precorrin-4 C11-methyltransferase) Cluster3563 1 0 0 0 1 1 1 ROD_21131(cobalamin biosynthesis protein CbiG) BN373_38231(cobalamin biosynthesis protein CbiG) t0846(CbiG protein) SL1344_2004(cobalamin biosynthesis protein) Cluster3564 1 0 0 0 1 1 1 ROD_21121(cobalt-precorrin-3B C(17)-methyltransferase) BN373_38221(precorrin-3B C17-methyltransferase) t0847(precorrin-3 C17-methyltransferase) SL1344_2003(precorrin-3 C17-methyltransferase) Cluster3565 1 0 0 0 1 1 1 ROD_21091(cobalt-precorrin-2 C(20)-methyltransferase (S-adenosyl-L-methionine--cobalt-precorrin-2 methyltransferase)) BN373_38191(precorrin-2 C20-methyltransferase) t0850(precorrin-2 C20-methyltransferase) SL1344_2000(cobalt-precorrin-2 C(20)-methyltransferase) Cluster3566 1 0 0 0 1 1 1 ROD_21071(cobalt transport protein CbiN) BN373_38171(cobalt transport protein) t0852(putative cobalt transport protein CbiN) SL1344_1998(putative cobalt transport protein CbiN) Cluster3567 1 0 0 0 1 1 1 ROD_21061(cobalt transport protein CbiQ) BN373_38161(cobalt ABC transporter, permease protein) t0853(putative cobalt transport protein CbiQ) SL1344_1997(putative cobalt transport protein) Cluster3568 1 0 0 0 1 1 1 ROD_21051(cobalt transport ATP-binding protein) BN373_38151(cobalt ABC transporter, ATP-binding protein) t0854(putative cobalt transport ATP-binding protein CbiO) SL1344_1996(putative cobalt transport ATP-binding protein) Cluster3569 1 0 0 0 1 1 1 ROD_21041(cobyric acid synthase) BN373_38141(cobyric acid synthase CobQ) t0855(putative cobyric acid synthase) SL1344_1995(putative cobyric acid synthase) Cluster3570 1 1 1 0 1 0 0 ROD_03501(putative MSF transporter protein) ENC_33000(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4623(Inner membrane metabolite transport protein ygcS,putative sialic acid transporter,Arabinose efflux permease,MFS transporter, aromatic acid:H+ symporter (AAHS) family,Sugar (and other) transporter) BN373_37881(transporter, major facilitator family) Cluster3571 1 0 0 0 1 1 1 ROD_30281(glycerate kinase 2) BN373_37731(putative glycerate kinase) t2868(conserved hypothetical protein) SL1344_2940(conserved hypothetical protein) Cluster3572 0 1 0 0 1 1 1 ENC_29940(Uncharacterized protein conserved in bacteria) BN373_37461(conserved hypothetical protein) t2811(hypothetical protein) SL1344_2889(conserved hypotheticalprotein) Cluster3573 0 1 0 0 1 1 1 ENC_29930(Arabinose efflux permease) BN373_37451(transporter, major facilitator family) t2812(possible membrane transport protein) SL1344_2890(possible membrane transport protein) Cluster3574 0 1 0 0 1 1 1 ENC_29920(transcriptional regulator, LysR family) BN373_37441(transcriptional regulator, LysR family) t2813(possible LysR-family transcriptional regulator) SL1344_2891(possible LysR-family transcriptional regulator) Cluster3575 1 1 0 0 2 0 0 ROD_41171(putative PTS system protein, component EIIc) ENC_03460(PTS system, lactose/cellobiose family IIC component) BN373_37071(PTS system, lactose/cellobiose family IIC subunit),BN373_46981(PTS system, lactose/cellobiose family IIC subunit) Cluster3576 1 1 0 1 1 0 0 ROD_30991(arbutin-, cellobiose-, and salicin-specific PTS system EIIBC component) ENC_29660(Phosphotransferase system IIB components) b2715(fused cellobiose/arbutin/salicin-specific PTS enzymes: IIB component/IC component) BN373_36841(PTS system, arbutin-, cellobiose-, and salicin-specific EIIBC component) Cluster3577 1 1 0 1 1 0 0 ROD_31001(cryptic asc operon repressor) ENC_29650(transcriptional regulator, LacI family) b2714(DNA-binding transcriptional repressor) BN373_36831(transcriptional regulator AscG) Cluster3578 0 1 0 0 1 1 1 ENC_17360(Uncharacterized protein conserved in bacteria) BN373_36011(bacteriophage p4 dna primase) t2656(hypothetical protein) SL1344_2722(bacteriophage P4 DNA primase) Cluster3579 0 1 1 1 1 0 0 ENC_37160(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1198(Inner membrane protein yphA,DoxX) b2543(predicted inner membrane protein) BN373_35331(putative inner membrane protein YphA) Cluster3580 1 0 1 1 1 0 0 ROD_24921(ROK-family regulatory protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1191(Making large colonies protein,N-acetylmannosamine kinase,ROK family protein (putative glucokinase),ROK family) b2550(predicted DNA-binding transcriptional regulator) BN373_35311(putative NAGC-like transcriptional regulator) Cluster3581 1 0 1 1 1 0 0 ROD_24911(putative TPR-domain protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1192(tetratricopeptide repeat protein,Flp pilus assembly protein TadD, contains TPR repeats,putative PEP-CTERM system TPR-repeat lipoprotein,Tetratricopeptide repeat) b2549(conserved protein) BN373_35301(putative transferase) Cluster3582 1 0 1 1 1 0 0 ROD_24891(putative aldose 1-epimerase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1197(putative aldose-1-epimerase,Aldose 1-epimerase) b2544(conserved protein) BN373_35281(conserved hypothetical protein) Cluster3583 1 1 0 0 1 0 1 ROD_24781(putative outer membrane protein) ENC_37200(ABC-type uncharacterized transport system, permease component) BN373_35241(transporter, Ni2+-Co2+ transporter (NiCoT) family) SL1344_2513(putative inner membrane protein) Cluster3584 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2341(Anaerobic sulfatase-maturating enzyme homolog YdeM,anaerobic sulfatase-maturase,Predicted metal-binding protein,anaerobic sulfatase maturase,Radical SAM superfamily) b1497(conserved protein) BN373_34911(putative arylsulfatase regulator) SL1344_1222(putative regulatory protein) Cluster3585 1 0 0 0 1 1 1 pseudoROD_23781(putative transcriptional regulator, GntR family (pseudogene)) BN373_34261(putative transcriptional regulator PtsJ) t0421(putative transcriptional regulator) SL1344_2399(putative transcriptional regulator) Cluster3586 1 0 1 1 1 0 0 ROD_27951(two-component system sensor kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1336(Inner membrane protein ypdA,Predicted signal transduction protein with a C-terminal ATPase domain,phosphate regulon sensor kinase PhoR,5TMR of 5TMR-LYT) b2380(predicted sensory kinase in two-component system with YpdB) BN373_34001(sensor histidine kinase) Cluster3587 0 0 3 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.13(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.32(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.14(hypothetical protein) BN373_33941(conserved hypothetical protein) Cluster3588 1 0 0 1 1 0 1 ROD_26201(putative prophage DNA-binding protein) b1147(e14 prophage; predicted DNA-binding transcriptional regulator) BN373_33831(conserved hypothetical protein) SL1344_1966(predicted bacteriophage protein) Cluster3589 1 1 0 0 1 1 0 ROD_02691(putative prophage membrane protein) ENC_17290(hypothetical protein) BN373_33741(conserved hypothetical protein) t1901(putative prophage membrane protein) Cluster3590 1 0 1 0 1 1 0 ROD_02681(putative prophage membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1947(Protein of unknown function (DUF754)) BN373_33731(conserved hypothetical protein) t1900(putative prophage membrane protein) Cluster3591 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1825(Phage terminase-like protein, large subunit,Phage Terminase) pseudob4693(unknown) BN373_33641(terminase) SL1344_1950(bacteriophage terminase (large subunit)) Cluster3592 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1827(phage portal protein, HK97 family,Phage portal protein) pseudob1151(unknown) BN373_33631(phage portal protein, hk97 family) SL1344_1949(putative portal protein) Cluster3593 1 0 0 0 2 0 1 ROD_22451(Major facilitator superfamily transporter) BN373_31441(D-arabinitol transporter),BN373_31511(putative transport protein) SL1344_4364(alpha-ketoglutarate permease) Cluster3594 1 0 0 0 1 1 1 ROD_41941(lipopolysaccharide 1,2-N-acetylglucosaminetransferase) BN373_31111(glycosyl transferase group 1) t3805(lipopolysaccharide 1,2-N-acetylglucosaminetransferase) SL1344_3680(lipopolysaccharide 1,2-N-acetylglucosaminetransferase) Cluster3595 0 0 1 0 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.756(Polysialic acid transport ATP-binding protein KpsT,teichoic acids export protein ATP-binding subunit,ABC-type Na+ transport system, ATPase component,daunorubicin resistance ABC transporter, ATP-binding protein,RecF/RecN/SMC N terminal domain) BN373_30961(lipopolysaccharide O-antigen ABC transport system ATP-binding component) t2153(putative polysaccharide export ABC transporter ATP-binding protein) SL1344_0705(ABC transporter domain protein) Cluster3596 0 0 0 1 1 1 1 b2036(UDP-galactopyranose mutase, FAD/NAD(P)-binding) BN373_30941(UDP-galactopyranose mutase) t2157(UDP-galactopyranose mutase) pseudoSL1344_0700(putative udp-galactopyranose mutase (pseudogene)) Cluster3597 1 1 0 0 1 0 1 ROD_06251(conserved hypothetical protein) ENC_05700(Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)) BN373_30521(hydrolase, alpha/beta fold family) SL1344_3055(putative hydrolase) Cluster3598 0 0 0 1 1 1 1 b2852(predictedtranscriptional regulator) BN373_30341(transcriptional regulator) t2778(invasion protein regulator) SL1344_2856(invasion protein regulator) Cluster3599 1 0 1 1 1 0 0 ROD_20641(LysR-family transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1765(HTH-type transcriptional regulator cbl,transcriptional regulator Cbl,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b1987(DNA-binding transcriptional activator for the ssuEADCB and tauABCD operons) BN373_30191(transcriptional regulator Cbl) Cluster3600 1 1 0 0 1 0 1 ROD_19581(Putative sugar phosphate isomerase) ENC_05810(Ribose 5-phosphate isomerase RpiB) BN373_29871(ribose/galactose isomerase family protein) SL1344_1866(Putative sugar phosphate isomerase) Cluster3601 1 0 1 1 1 0 0 ROD_19561(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1981(Protein of unknown function (DUF2766)) b4537(predicted protein) BN373_29851(conserved hypothetical protein) Cluster3602 1 0 0 0 1 1 1 ROD_19211(conserved hypothetical protein) BN373_29751(glycosyl hydrolase, family 88) t0966(conserved hypothetical protein) SL1344_1846(conserved hypothetical protein) Cluster3603 1 0 0 0 1 1 1 ROD_18341(conserved hypothetical protein) BN373_28971(conserved hypothetical protein) t1069(conserved hypothetical protein) SL1344_1736(conserved hypothetical protein) Cluster3604 0 1 0 0 1 1 1 ENC_44390(TonB-dependent siderophore receptor) BN373_28871(ferrioxamine receptor) t2500(ferrioxamine B receptor precursor) SL1344_0359(ferrioxamine B receptor precursor) Cluster3605 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3624(3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase,3-(3-hydroxyphenyl)propionate hydroxylase,ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family,FAD binding domain) b0347(3-(3-hydroxyphenyl)propionate hydroxylase) BN373_27071(3-(3-hydroxy-phenyl)propionate hydroxylase) SL1344_1475(putative monooxygenase) Cluster3606 0 1 1 1 1 0 0 ENC_44220(Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3622(2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxonon atrienedioate hydrolase,acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase,Ketosteroid isomerase-related protein,2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase,Alpha/beta hydrolase family) b0349(2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase) BN373_27051(2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase) Cluster3607 1 0 1 1 1 0 0 ROD_33951(putative amidohydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.876(hypothetical protein,putative chlorohydrolase/aminohydrolase,Cytosine deaminase and related metal-dependent hydrolases,putative selenium metabolism protein SsnA,Amidohydrolase family) b2879(predicted chlorohydrolase/aminohydrolase) BN373_26201(amidohydrolase family protein) Cluster3608 1 1 0 0 1 0 1 ROD_41231(putative membrane protein) ENC_17830(hypothetical protein) BN373_26091(conserved hypothetical protein) SL1344_3727(putative inner membrane protein) Cluster3609 0 1 1 1 1 0 0 ENC_08550(diguanylate cyclase (GGDEF) domain) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2885(Probable diguanylate cyclase YcdT,response regulator PleD,Response regulator containing a CheY-like receiver domain and a GGDEF domain,diguanylate cyclase (GGDEF) domain,GGDEF domain) b1025(diguanylate cyclase) BN373_25611(conserved hypothetical protein) Cluster3610 1 1 0 1 1 0 0 ROD_14441(beta-lactam resistance protein) ENC_12940(hypothetical protein) b4409(beta-lactam resistance membrane protein) BN373_25421(beta-lactam resistance protein) Cluster3611 1 0 1 1 1 0 0 ROD_15941(ABC transporter, substrate-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2380(Putrescine-binding periplasmic protein precursor,putrescine transporter subunit: periplasmic-binding component of ABC superfamily,Maltose-binding periplasmic proteins/domains,Bacterial extracellular solute-binding protein) b1440(polyhydroxybutyrate (PHB) synthase, ABC transporter periplasmic binding protein homolog) BN373_25061(ABC transporter, periplasmic substrate-binding protein) Cluster3612 1 0 1 1 1 0 0 ROD_15931(ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2379(Spermidine/putrescine import ATP-binding protein PotA,putrescine/spermidine ABC transporter ATPase protein,ABC-type spermidine/putrescine transport systems, ATPase components,polyamine ABC transporter, ATP-binding protein,ABC transporter) b1441(predicted spermidine/putrescine transporter subunit) BN373_25051(ABC transporter, ATP-binding protein) Cluster3613 1 0 1 1 1 0 0 ROD_15921(ABC transporter, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2378(Inner membrane ABC transporter permease protein ydcU,spermidine/putrescine ABC transporter membrane protein,ABC-type molybdate transport system, permease component,NifC-like ABC-type porter,Binding-protein-dependent transport system inner membrane component) b1442(predicted spermidine/putrescine transporter subunit) BN373_25041(ABC transporter, permease protein) Cluster3614 1 0 1 1 1 0 0 ROD_15911(ABC transporter, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2377(Inner membrane ABC transporter permease protein ydcV,spermidine/putrescine ABC transporter membrane protein,ABC-type molybdate transport system, permease component,molybdate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component) b1443(predicted spermidine/putrescine transporter subunit) BN373_25031(ABC transporter, permease protein) Cluster3615 0 1 1 1 1 0 0 ENC_14980(Protein of unknown function (DUF2543).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2464(Protein of unknown function (DUF2543)) b1295(predicted protein) BN373_24241(conserved hypothetical protein) Cluster3616 1 0 1 1 1 0 0 ROD_12791(major facilitator superfamily protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2105(Inner membrane metabolite transport protein ydjE,putative 3-hydroxyphenylpropionic transporter MhpT,Arabinose efflux permease,MFS transporter, aromatic acid:H+ symporter (AAHS) family,Major Facilitator Superfamily) b1775(predicted transporter) BN373_24011(transporter, major facilitator family) Cluster3617 1 0 1 1 1 0 0 ROD_16621(putative signaling protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2425(Probable diguanylate cyclase YdaM,putative diguanylate cyclase YedQ,Response regulator containing a CheY-like receiver domain and a GGDEF domain,diguanylate cyclase (GGDEF) domain,GGDEF domain) b1341(diguanylate cyclase, csgD regulator) BN373_23691(conserved hypothetical protein) Cluster3618 0 0 3 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3477(Protein of unknown function (DUF2931)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3478(Protein of unknown function (DUF2931)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3479(Protein of unknown function (DUF2931)) BN373_23661(conserved hypothetical protein) Cluster3619 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3469(Allantoin transport protein,allantoin permease,NCS1 nucleoside transporter family,Permease for cytosine/purines, uracil, thiamine, allantoin) b0511(predicted allantoin transporter) BN373_23641(permease, cytosine/purine, uracil, thiamine, allantoin family) SL1344_0515(putative allantoin permease) Cluster3620 1 0 0 0 1 1 1 ROD_27051(PTS system EIIA component) BN373_23231(PTS family enzyme IIA, mannitol-specific, cryptic) t0520(putative sugar phosphotransferase component II A) SL1344_2313(putative sugar phosphotransferase component II A) Cluster3621 1 0 0 0 1 1 1 ROD_27041(PTS system EIIB component) BN373_23221(ascorbate-specific PTS family enzyme IIB component) t0521(putative sugar phosphotransferase component II B) SL1344_2312(putative sugar phosphotransferase component II B) Cluster3622 0 0 1 0 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1748(Uncharacterized membrane protein,Protein of unknown function (DUF1355)) BN373_23101(conserved hypothetical protein) t3973(hypothetical protein) SL1344_3514(conserved hypothetical protein) Cluster3623 0 0 1 0 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1746(Phosphotriesterase homology protein,putative hydrolase,Phosphotriesterase family) BN373_23091(phosphotriesterase family protein) t3971(puative phophotriesterase) SL1344_3516(puative phophotriesterase) Cluster3624 0 0 1 0 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4420(C4-dicarboxylate transport sensor protein dctB,sensory histidine kinase AtoS,Signal transduction histidine kinase regulating C4-dicarboxylate transport system,putative PEP-CTERM system histidine kinase,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) BN373_22971(phosphoglycerate transport system sensor protein) t0461(phosphoglycerate transport system sensor protein PgtB) SL1344_2365(phosphoglycerate transport system sensor protein PgtB) Cluster3625 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2185(Acetate CoA-transferase subunit alpha,acetyl-CoA:acetoacetyl-CoA transferase subunit alpha,Acyl CoA:acetate/3-ketoacid CoA transferase,3-oxoacid CoA-transferase, A subunit,Coenzyme A transferase) b1694(fused predicted acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit) BN373_22771(bifunctional putative acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit) SL1344_1291(putative acetyl CoA transferase) Cluster3626 0 1 0 0 1 1 1 ENC_19100(Predicted hydrolase of the alpha/beta superfamily) BN373_22581(putative oxidoreductase, Fe-S subunit) t2671(putative exported protein) SL1344_2761(putative exported protein) Cluster3627 1 0 1 1 1 0 0 ROD_15241(puative trans-aconitate methyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2327(Trans-aconitate 2-methyltransferase,trans-aconitate 2-methyltransferase,Trans-aconitate methyltransferase,biotin biosynthesis protein BioC,Methyltransferase domain) b1519(trans-aconitate methyltransferase) BN373_22241(trans-aconitate 2-methyltransferase) Cluster3628 1 0 1 1 1 0 0 ROD_15221(altronate oxidoreductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2325(Altronate oxidoreductase,altronate oxidoreductase,Mannitol-1-phosphate/altronate dehydrogenases,Mannitol dehydrogenase C-terminal domain) b1521(altronate oxidoreductase, NAD-dependent) BN373_22161(tagaturonate reductase) Cluster3629 1 0 1 1 1 0 0 ROD_15211(putative signal transduction protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2324(Probable diguanylate cyclase YcdT,putative diguanylate cyclase YedQ,Response regulator containing a CheY-like receiver domain and a GGDEF domain,diguanylate cyclase (GGDEF) domain,GGDEF domain) b1522(predicted diguanylate cyclase) BN373_22141(putative membrane-bound diguanylate cyclase) Cluster3630 1 1 0 0 2 0 0 ROD_04011(putative AraC-family transcriptional regulator) ENC_36020(transcriptional regulator, AraC family with amidase-like domain) BN373_21811(transcriptional regulator, AraC family),BN373_46681(transcriptional regulator, AraC family) Cluster3631 1 0 1 1 1 0 0 ROD_03991(beta-galactosidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3627(Beta-galactosidase,beta-D-galactosidase,Tryptopha n synthase alpha chain,Glycosyl hydrolases family 2, TIM barrel domain) b0344(beta-D-galactosidase) BN373_21771(beta-galactosidase) Cluster3632 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1039(2-hydroxy-3-oxopropionate reductase,tartronate semialdehyde reductase,Uncharacterized protein conserved in bacteria,2-hydroxy-3-oxopropionate reductase,NAD binding domain of 6-phosphogluconate dehydrogenase) b2736(predicted dehydrogenase, with NAD(P)-binding Rossmann-fold domain) BN373_21671(3-hydroxyisobutyrate dehydrogenase family protein) SL1344_2897(conserved hypothetical protein) Cluster3633 1 0 0 0 1 1 1 ROD_34091(putative heat shock protein) BN373_21541(heat shock protein) t1128(putative heat shock protein) SL1344_1187(putative heat shock protein) Cluster3634 1 0 1 1 1 0 0 ROD_48471(major facilitator superfamily protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4043(L-galactonate transporter,regulatory protein UhpC,Arabinose efflux permease,D-galactonate transporter,Major Facilitator Superfamily) b4356(L-galactonate transporter) BN373_21431(transporter, major facilitator family) Cluster3635 1 1 0 0 1 0 1 ROD_44651(Malonate utilisation transcriptional regulator MdcR) ENC_25540(Transcriptional regulator) BN373_21111(malonate utilization transcriptional regulator MdcR) SL1344_3427(conserved hypothetical protein) Cluster3636 1 0 1 1 1 0 0 ROD_14581(putative short chain dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2277(Dihydrofolate reductase folM,dihydromonapterin reductase,Uncharacterized conserved protein,3-oxoacyl-[acyl-carrier-protein] reductase,short chain dehydrogenase) b1606(dihydromonapterin reductase, NADPH-dependent; dihydrofolate reductase isozyme) BN373_20791(oxidoreductase, short chain dehydrogenase/reductase family) Cluster3637 1 0 1 1 1 0 0 ROD_14491(maltose regulon regulatory protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2261(Degradation activator,DNA-binding transcriptional repressor MalI,ABC-type sugar transport system, periplasmic component,catabolite control protein A,Periplasmic binding proteins and sugar binding domain of LacI family) b1620(transcriptional repressor of Mal regulon) BN373_20691(maltose regulon regulatory protein MalI) Cluster3638 1 0 1 1 1 0 0 ROD_16221(glyceraldehyde-3-phosphate dehydrogenase C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2400(Glyceraldehyde-3-phosphate dehydrogenase,glyceraldehyde-3-phosphate dehydrogenase,Transketolase,glyceraldehyde-3-phosphate dehydrogenase, type I,Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain) pseudob4493(unknown) BN373_20581(glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)) Cluster3639 0 0 1 0 2 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3671(hypothetical protein,putative oxidoreductase,Predicted oxidoreductase,voltage-dependent potassium channel beta subunit,Aldo/keto reductase family) BN373_20461(putative aldo-keto reductase/oxidoreductase),BN373_22921(putative dehydrogenase) t0142(putative aldo/keto reductase) Cluster3640 0 1 1 0 2 0 0 ENC_11380(Multidrug resistance efflux pump) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2428(Inner membrane protein yibH,multidrug efflux system protein EmrA,efflux pump membrane protein,HlyD family secretion protein) BN373_20421(auxiliary transport protein, membrane fusion protein (MFP) family),BN373_23501(auxiliary transport protein, membrane fusion protein (MFP) family) Cluster3641 0 1 1 1 1 0 0 ENC_11790(transcriptional regulator, AraC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2408(Transcriptional activator feaR,DNA-binding transcriptional activator FeaR,DNA gyrase inhibitor,YSIRK-targeted surface antigen transcriptional regulator,Helix-turn-helix domain) b1384(DNA-binding transcriptional activator for tynA and feaB) BN373_20081(transcriptional activator FeaR) Cluster3642 0 1 1 0 2 0 0 ENC_09060(type VI secretion protein, VC_A0110 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.933(Uncharacterized protein conserved in bacteria,type VI secretion protein, VC_A0110 family,Bacterial protein of unknown function (DUF879)) BN373_19661(type VI secretion protein),BN373_28441(conserved hypothetical protein) Cluster3643 0 1 1 0 2 0 0 ENC_08920(type VI secretion protein, VC_A0114 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.955(Uncharacterized protein conserved in bacteria,type VI secretion protein, VC_A0114 family,Bacterial protein of unknown function (DUF876)) BN373_19511(conserved hypothetical protein),BN373_28541(conserved hypothetical protein) Cluster3644 1 1 1 0 1 0 0 ROD_34171(T6SS protein Cts2S) ENC_08900(type VI secretion protein, VC_A0107 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.957(Uncharacterized protein conserved in bacteria,type VI secretion protein, VC_A0107 family,Protein of unknown function (DUF770)) BN373_19491(conserved hypothetical protein) Cluster3645 0 0 1 0 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3667(Uncharacterized oxidoreductase YtbE,2,5-diketo-D-gluconate reductase A,Predicted oxidoreductase,Aldo/keto reductase family) BN373_19421(oxidoreductase, aldo/keto reductase family) t1580(putative oxidoreductase) SL1344_1606(putative oxidoreductase) Cluster3646 0 1 1 1 1 0 0 ENC_12220(Hydrolases of the alpha/beta superfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2438(hypothetical protein,Uncharacterized conserved protein,Alpha/beta hydrolase family) b1327(predicted hydrolase) BN373_19401(conserved hypothetical protein) Cluster3647 1 1 1 0 1 0 0 ROD_30391(probable hydrolase) ENC_30160(amidohydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4537(Uncharacterized hydrolase YxeP,allantoate amidohydrolase,Metal-dependent amidase/aminoacylase/carboxypeptidase,amidohydrolase,Peptid ase family M20/M25/M40) BN373_19211(amidohydrolase family protein) Cluster3648 0 1 1 1 1 0 0 ENC_14400(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2138(Various environmental stresses-induced protein,hypothetical protein,Uncharacterized protein conserved in bacteria,HutD) b1742(conserved protein) BN373_19111(conserved hypothetical protein) Cluster3649 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2479(hypothetical protein) b4596(hypothetical protein) BN373_19071(conserved hypothetical protein) SL1344_1635(conserved hypothetical protein) Cluster3650 0 0 0 1 1 1 1 b0288(predicted ferredoxin) BN373_18701(conserved hypothetical protein) t1645(conserved hypothetical protein) SL1344_1664(conserved hypothetical protein) Cluster3651 0 1 1 1 1 0 0 ENC_14930(diguanylate cyclase with GAF sensor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2087(Probable diguanylate cyclase YeaP,RNase II stability modulator,MHYT domain (predicted integral membrane sensor domain),diguanylate cyclase (GGDEF) domain,GGDEF domain) b1794(diguanylate cyclase) BN373_17941(GAF domain/diguanylate cyclase) Cluster3652 1 1 0 1 1 0 0 ROD_15461(diguanylate cyclase YddV) ENC_38680(diguanylate cyclase (GGDEF) domain) b1490(diguanylate cyclase; cold-and stationary phase-induced oxygen-dependent biofilm regulator; positively regulates csgBAC and pgaABCD) BN373_17861(putative membrane-bound diguanylate cyclase) Cluster3653 2 1 0 0 1 0 0 ROD_29091(conserved hypothetical protein),ROD_49881(conserved hypothetical protein) ENC_09660(hypothetical protein) BN373_17811(conserved hypothetical protein) Cluster3654 0 1 0 0 1 1 1 ENC_16050(transcriptional regulator, LysR family) BN373_16671(transcriptional regulator, LysR family) t1981(hypothetical transcriptional activator) SL1344_0890(hypothetical transcriptional activator) Cluster3655 0 1 0 0 1 1 1 ENC_16060(Pirin-related protein) BN373_16661(pirin family protein) t1982(putative pirin-related protein) SL1344_0889(putative pirin-related protein) Cluster3656 1 0 1 1 1 0 0 ROD_10711(ferrous iron permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2893(Ferrous iron uptake protein,FTR1 family protein,Iron permease FTR1 family) pseudob4490(unknown) BN373_16601(ferrous iron permease EfeU) Cluster3657 0 1 1 1 1 0 0 ENC_16300(pyrimidine utilization protein B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2898(Peroxyureidoacrylate/ureidoacrylate amidohydrolase RutB,putative hydrolase,pyrimidine utilization protein B,Isochorismatase family) b1011(ureidoacrylate amidohydrolase) BN373_16521(putative isochorismatase family protein, rutB) Cluster3658 0 1 1 1 1 0 0 ENC_16310(pyrimidine utilization protein C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2899(Putative aminoacrylate peracid reductase RutC,putative endoribonuclease L-PSP,pyrimidine utilization protein C,Endoribonuclease L-PSP) b1010(putative aminoacrylate peracid reductase) BN373_16511(rutC protein) Cluster3659 0 1 1 1 1 0 0 ENC_16320(pyrimidine utilization protein D) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2900(Putative aminoacrylate hydrolase RutD,acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase,Esterase/lipase,pyrimidine utilization protein D,Alpha/beta hydrolase family) b1009(putative aminoacrylate hydrolase) BN373_16501(putative rutD protein) Cluster3660 0 1 1 1 1 0 0 ENC_16330(Nitroreductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2901(Probable malonic semialdehyde reductase RutE,malonic semialdehyde reductase,Nitroreductase family) b1008(malonic semialdehyde reductase) BN373_16491(putative rutE protein) Cluster3661 0 1 1 1 1 0 0 ENC_16340(pyrimidine utilization flavin reductase protein F) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2902(FMN reductase (NADH) RutF,4-hydroxyphenylacetate 3-monooxygenase reductase subunit,pyrimidine utilization flavin reductase protein F,Flavin reductase like domain) b1007(flavin:NADH reductase) BN373_16481(putative flavin reductase rutF) Cluster3662 0 1 1 1 1 0 0 ENC_16350(pyrimidine utilization transport protein G) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2903(Putative pyrimidine permease RutG,uracil transporter,pyrimidine utilization transport protein G,Permease family) b1006(pyrimidine permease) BN373_16471(putative pyrimidine permease RutG) Cluster3663 1 0 0 1 1 0 1 ROD_18411(LysR-family transcriptional regulator) b1799(DNA-binding transcriptional activator for dmlA) BN373_16291(transcriptional regulator, LysR family) SL1344_0328(putative lysR family transcriptional regulator) Cluster3664 3 0 0 0 1 0 0 ROD_48331(conserved hypothetical protein),ROD_50011(putative DNA helicase),pseudoROD_10771(putative DNA helicase (fragment)) BN373_16171(superfamily i dna and rna helicase-like protein) Cluster3665 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1889(Urease operon transcriptional activator,transcriptional regulator SirC,Adenosine deaminase,Helix-turn-helix domain) b0546(DLP12 prophage; predicted DNA-binding transcriptional regulator) BN373_16101(putative transcriptional regulator, AraC family) SL1344_1022(putative transcriptional regulator) Cluster3666 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1888(hypothetical protein,putative kinase inhibitor,Phospholipid-binding protein,Raf kinase inhibitor-like protein, YbhB/YbcL family,Phosphatidylethanolamine-binding protein) b0545(DLP12 prophage; secreted protein, UPF0098 family) BN373_16091(phosphatidylethanolamine-binding protein) SL1344_1021(putative exported protein) Cluster3667 1 0 1 1 1 0 0 ROD_10041(alkanesulfonate monooxygenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2958(Alkanesulfonate monooxygenase,alkanesulfonate monooxygenase,alkanesulfonate monooxygenase, FMNH(2)-dependent,Luciferase-like monooxygenase) b0935(alkanesulfonate monooxygenase, FMNH(2)-dependent) BN373_15831(alkanesulfonate monooxygenase, FMNH(2)-dependent) Cluster3668 0 0 1 0 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1859(Porin OmpF,outer membrane protein F,Outer membrane protein (porin),Gram-negative porin) BN373_15721(outer membrane porin, OmpF family) t1935(outer membrane protein F precursor) SL1344_0936(outer membrane protein F precursor) Cluster3669 0 0 0 0 1 2 1 BN373_14921(prophage P2 OGR-like protein) t3445(putative positive regulator of late gene transcription),t4294(putative positive regulator of late gene transcription) SL1344_2665(putative positive regulator of late gene transcription) Cluster3670 0 0 1 0 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.21(P2 phage tail completion protein R (GpR)) BN373_14751(tail completion protein R (GpR)) t3427(putative phage tail protein) SL1344_2682(putative bacteriophage tail protein) Cluster3671 0 0 0 0 1 2 1 BN373_14591(TraR/DksA family transcriptional regulator) t3408(hypothetical protein),t4331(hypothetical protein) SL1344_2703(hypothetical bacteriophage protein) Cluster3672 0 0 0 0 1 2 1 BN373_14581(conserved hypothetical protein) t3407(hypothetical protein),t4332(hypothetical protein) SL1344_2638(predicted bacteriophage protein) Cluster3673 0 0 0 0 1 2 1 BN373_14571(conserved hypothetical protein) t3406(conserved hypothetical protein),t4333(conserved hypothetical protein) SL1344_2704(hypothetical bacteriophage protein) Cluster3674 0 0 0 0 1 1 2 BN373_14561(conserved hypothetical protein) t4334(hypothetical protein) SL1344_2636(predicted bacteriophage protein),SL1344_2705(hypothetical bacteriophage protein) Cluster3675 0 0 0 0 1 2 1 BN373_14551(phage regulatory CII family protein) t3404(regulatory protein cII),t4335(phage regulatory protein) SL1344_2706(bacteriophage regulatory protein) Cluster3676 0 0 0 0 1 2 1 BN373_14531(repressor protein) t3402(repressor protein),t4337(phage repressor protein cI) SL1344_2708(bacteriophage repressor protein cI) Cluster3677 1 0 1 1 1 0 0 ROD_15381(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2719(hypothetical protein) b1164(connector protein for RcsB regulation of biofilm and acid-resistance) BN373_13401(conserved hypothetical protein) Cluster3678 0 1 1 1 1 0 0 ENC_21580(transcriptional repressor BetI) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3651(Uncharacterized HTH-type transcriptional regulator yvdT,transcriptional regulator BetI,transcriptional repressor BetI,Bacterial regulatory proteins, tetR family) b0313(DNA-binding transcriptional repressor) BN373_11631(transcriptional repressor BetI) Cluster3679 0 1 1 1 1 0 0 ENC_21590(betaine aldehyde dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3652(Betaine aldehyde dehydrogenase,betaine aldehyde dehydrogenase,Delta 1-pyrroline-5-carboxylate dehydrogenase,betaine aldehyde dehydrogenase,Aldehyde dehydrogenase family) b0312(betaine aldehyde dehydrogenase, NAD-dependent) BN373_11621(betaine-aldehyde dehydrogenase) Cluster3680 0 1 1 1 1 0 0 ENC_21630(ABC-type dipeptide/oligopeptide/nickel transport systems, permease components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4391(Probable D,D-dipeptide transport system permease protein ddpC,D-ala-D-ala transporter subunit,ABC-type antimicrobial peptide transport system, permease component,nickel ABC transporter, permease subunit NikC,Binding-protein-dependent transport system inner membrane component) b1485(D-ala-D-ala transporter subunit) BN373_11561(ABC transporter, permease protein) Cluster3681 1 0 0 0 1 1 1 ROD_05701(putative tetR-family transcriptional regulator) BN373_11261(conserved hypothetical protein) t2288(putative TetR-family transcriptional regulator) SL1344_0568(putative tetR-family transcriptional regulator) Cluster3682 0 0 1 0 1 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1003(5-dehydro-2-deoxygluconokinase,aminoimidazole riboside kinase,Uncharacterized protein conserved in bacteria,ribokinase,pfkB family carbohydrate kinase) BN373_10791(fructokinase) t3552(putative carbohydrate kinase) SL1344_4015(putative carbohydrate kinase) Cluster3683 1 1 1 0 1 0 0 ROD_28421(putative transcriptional regulator) ENC_23270(transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.999(Catabolite repressor/activator,DNA-binding transcriptional regulator FruR,ABC-type sugar transport system, periplasmic component,D-fructose-responsive transcription factor,Bacterial regulatory proteins, lacI family) BN373_10751(sucrose operon repressor) Cluster3684 1 1 0 0 1 0 1 ROD_32741(putative oxidoreductase) ENC_43230(Predicted dehydrogenases and related proteins) BN373_10681(oxidoreductase, NAD binding) SL1344_2737(putative dehydrogenase) Cluster3685 0 0 0 0 1 1 2 BN373_10101(phage NinG protein) t1905(hypothetical prophage protein) SL1344_0959(ninG),SL1344_2581(predicted bacteriophage protein) Cluster3686 2 0 1 0 1 0 0 ROD_19971(hypothetical prophage protein),ROD_36901(hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3062(Uncharacterized protein conserved in archaea) BN373_09991(conserved hypothetical protein) Cluster3687 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2766(Replication protein P) pseudob4508(unknown) BN373_09981(predicted replication protein) SL1344_2590(replication protein P) Cluster3688 0 0 1 1 1 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2771(FtsZ inhibitor protein KilR,FtsZ inhibitor protein) b1352(Rac prophage; inhibitor of ftsZ, killing protein) BN373_09871(putative prophage Kil protein) t1921(prophage Kil protein) Cluster3689 0 0 1 1 1 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2774(putative phage-type endonuclease,YqaJ-like viral recombinase domain) pseudob0539(unknown) BN373_09831(exonuclease) t1924(exonuclease) Cluster3690 1 0 0 0 1 1 1 pseudoROD_05231(putative transposase (pseudogene)) BN373_09351(conserved hypothetical protein) t2381(conserved hypothetical protein) SL1344_0472(conserved hypothetical protein) Cluster3691 0 1 0 0 1 1 1 ENC_44250(Predicted metal-dependent hydrolase with the TIM-barrel fold) BN373_08361(amidohydrolase family protein) t1340(conserved hypothetical protein) SL1344_1403(conserved hypothetical protein) Cluster3692 1 0 1 1 1 0 0 ROD_04271(alkaline phosphatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3598(Alkaline phosphatase precursor,alkaline phosphatase,Alkaline phosphatase) b0383(bacterial alkaline phosphatase) BN373_08151(alkaline phosphatase) Cluster3693 1 0 0 0 1 1 1 ROD_04241(putative membrane protein) BN373_08121(extensin domain protein) t2483(hypothetical protein) SL1344_0376(hypothetical protein) Cluster3694 1 0 1 1 1 0 0 ROD_04121(taurine ABC transporter, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3611(Putative aliphatic sulfonates transport permease protein ssuC,taurine transporter subunit,ABC-type anion transport system, duplicated permease component,nitrate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component) b0367(taurine transporter subunit) BN373_08011(taurine ABC transporter, permease protein) Cluster3695 1 0 1 1 1 0 0 ROD_29261(putative regulatory protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3679(Bacterial regulatory proteins, luxR family) b0294(predicted regulator) BN373_07781(putative transcriptional regulator MatA) Cluster3696 0 1 1 1 1 0 0 ENC_05390(phosphonate ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4360(Phosphate-import ATP-binding protein PhnC,phosphonate/organophosphate ester transporter subunit,ABC-type phosphate/phosphonate transport system, ATPase component,phosphonate ABC transporter, ATP-binding protein,ABC transporter) b4106(phosphonate/organophosphate ester transporter subunit) BN373_07771(phosphonate ABC transporter, ATP-binding protein) Cluster3697 0 1 1 1 1 0 0 ENC_05380(phosphonate ABC transporter, periplasmic phosphonate binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4361(Phosphate-import protein phnD precursor,phosphonate ABC transporter, periplasmic phosphonate binding protein,ABC transporter, phosphonate, periplasmic substrate-binding protein) b4105(phosphonate/organophosphate ester transporter subunit) BN373_07761(phosphonate ABC transporter, periplasmic phosphonate-binding protein) Cluster3698 0 1 1 1 1 0 0 ENC_05370(phosphonate ABC transporter, permease protein PhnE) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4362(Phosphate-import permease protein phnE,DL-methionine transporter permease subunit,ABC-type phosphate/phosphonate transport system, permease component,phosphonate ABC transporter, permease protein PhnE,Binding-protein-dependent transport system inner membrane component) pseudob4104(unknown) BN373_07751(phosphonate ABC transporter, permease protein) Cluster3699 1 0 1 1 1 0 0 ROD_45441(ABC transporter, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.424(Inner membrane amino-acid ABC transporter permease protein yhdY,amino acid ABC transporter permease,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component) b3270(predicted amino-acid transporter subunit) BN373_07651(polar amino acid ABC transporter inner membrane subunit) Cluster3700 0 0 0 0 2 1 1 BN373_07541(Glu/Leu/Phe/Val dehydrogenase),BN373_20471(putative glutamate dehydrogenase) t1082(glutamate dehydrogenase) SL1344_1723(glutamate dehydrogenase) Cluster3701 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1116(Gamma-aminobutyrate permease,gamma-aminobutyrate transporter,Amino acid transporters,GABA permease,Amino acid permease) b2663(gamma-aminobutyrate transporter) BN373_07381(GABA permease) SL1344_2777(GabA permease (4-amino butyrate transport carrier)) Cluster3702 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1162(HTH-type transcriptional activator CmpR,putative DNA-binding transcriptional regulator,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b2577(predicted DNA-binding transcriptional regulator) BN373_07161(LysR family transcriptional regulator) SL1344_2608(LysR-family transcriptional regulator) Cluster3703 0 1 0 0 1 1 1 ENC_24860(Arabinose efflux permease) BN373_07081(transporter, major facilitator family) t2608(putative drug efflux protein) SL1344_0252(putative drug efflux protein) Cluster3704 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2187(Quinate/shikimate dehydrogenase,quinate/shikimate dehydrogenase,5-enolpyruvylshikimate-3-phosphate synthase,shikimate 5-dehydrogenase,Shikimate dehydrogenase substrate binding domain) b1692(quinate/shikimate 5-dehydrogenase, NAD(P)-binding) BN373_05631(putative shikimate 5-dehydrogenase) SL1344_1293(Shikimate 5-dehydrogenase) Cluster3705 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2189(Inner membrane transport protein ydiM,multidrug efflux system translocase MdfA,MFS transporter, aromatic acid:H+ symporter (AAHS) family,Major Facilitator Superfamily) b1690(inner membrane protein, predicted transporter) BN373_05621(transporter, major facilitator family) SL1344_1296(putative MFS-family transport protein) Cluster3706 1 1 0 1 1 0 0 ROD_00781(sugar efflux transporter A) ENC_45830(sugar efflux transporter) b0070(broad specificity sugar efflux system) BN373_05581(sugar efflux transporter A) Cluster3707 0 1 0 0 1 1 1 ENC_32150(triphosphoribosyl-dephospho-CoA synthase CitG) BN373_05231(triphosphoribosyl-dephospho-CoA synthase) t0065(CitG protein) SL1344_0064(triphosphoribosyl-dephospho-CoA synthase) Cluster3708 1 0 0 0 1 1 1 ROD_48701(putative membrane protein) BN373_04501(membrane-associated diguanylate cyclase) t4594(putative membrane protein) SL1344_4482(putative membrane protein) Cluster3709 0 1 0 0 1 1 1 ENC_44870(Uncharacterized conserved protein) BN373_04471(YbaK/prolyl-tRNA synthetase-associated domain protein) t4592(conserved hypothetical protein) SL1344_4480(conserved hypothetical protein) Cluster3710 0 1 0 0 1 1 1 ENC_44740(hypothetical protein) BN373_04151(homoprotocatechuate degradative operon repressor) t1819(homoprotocatechuate degradative operon repressor) SL1344_1039(homoprotocatechuate degradative operon repressor) Cluster3711 0 1 0 0 1 1 1 ENC_44720(5-carboxy-2-oxohept-3-enedioate decarboxylase HpaG1 subunit /5-carboxy-2-oxohept-3-enedioate decarboxylase HpaG2 subunit) BN373_04131(4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit) t1818(2-hydroxyhepta-2,4-diene-1,7-dioate isomerase) SL1344_1040(4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase [includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase) Cluster3712 0 1 0 0 1 1 1 ENC_44700(3,4-dihydroxyphenylacetate 2,3-dioxygenase) BN373_04111(3,4-dihydroxyphenylacetate 2,3-dioxygenase) t1816(3,4-dihydroxyphenylacetate 2,3-dioxygenase) SL1344_1042(3,4-dihydroxyphenylacetate 2,3-dioxygenase) Cluster3713 0 1 0 0 1 1 1 ENC_44690(5-carboxymethyl-2-hydroxymuconate delta isomerase) BN373_04101(5-carboxymethyl-2-hydroxymuconate delta isomerase) t1815(5-carboxymethyl-2-hydroxymuconate delta-isomerase) SL1344_1043(5-carboxymethyl-2-hydroxymuconate delta-isomerase) Cluster3714 0 1 0 0 1 1 1 ENC_44680(2-oxohept-3-enedioate hydratase) BN373_04091(2-oxo-hepta-3-ene-1,7-dioic acid hydratase) t1814(2-oxo-hepta-3-ene-1,7-dioic acid hydratase) SL1344_1044(2-oxo-hepta-3-ene-1,7-dioic acid hydratase) Cluster3715 0 1 0 0 1 1 1 ENC_44670(2,4-dihydroxyhept-2-enedioate aldolase) BN373_04081(2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase) t1813(2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase) SL1344_1045(2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase) Cluster3716 0 1 0 0 1 1 1 ENC_44650(transcriptional regulator, AraC family) BN373_04061(4-hydroxyphenylacetate catabolism regulatory protein HpaA) t1811(4-hydroxyphenylacetate 3-monooxygenase operon regulatory protein) SL1344_1047(4-hydroxyphenylacetate 3-monooxygenase operon regulatory protein) Cluster3717 0 1 0 0 1 1 1 ENC_44640(4-hydroxyphenylacetate 3-monooxygenase oxygenase component) BN373_04051(4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit) t1820(4-hydroxyphenylacetate 3-monooxygenase) SL1344_1038(4-hydroxyphenylacetate 3-monooxygenase) Cluster3718 0 1 0 0 1 1 1 ENC_44630(4-hydroxyphenylacetate 3-monooxygenase reductase component) BN373_04041(4-hydroxyphenylacetate 3-monooxygenase, reductase component) t1821(4-hydroxyphenylacetate 3-monooxygenase coupling protein) SL1344_1037(4-hydroxyphenylacetate 3-monooxygenase coupling protein) Cluster3719 0 1 1 1 1 0 0 ENC_44400(transcriptional regulator, GntR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4056(Uncharacterized HTH-type transcriptional regulator yjiR,aspartate aminotransferase,Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase,tyrosine/nicotianamine family aminotransferase,Aminotransferase class I and II) b4340(fused predicted DNA-binding transcriptional regulator/predicted aminotransferase) BN373_03831(transcriptional regulator, GntR family/aminotransferase family protein) Cluster3720 1 1 0 0 2 0 0 ROD_13991(LysR-family transcriptional regulator) ENC_03540(transcriptional regulator, LysR family) BN373_03811(transcriptional regulator, LysR family),BN373_49071(transcriptional regulator, LysR family) Cluster3721 0 1 0 0 1 1 1 ENC_44170(tryptophanyl-tRNA synthetase) BN373_03751(tryptophanyl-tRNA synthetase) t4557(probable tryptophanyl-tRNA synthetase) SL1344_4438(probable tryptophanyl-tRNA synthetase) Cluster3722 0 0 1 1 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.211(Inner membrane transport permease yhhJ,ABC-type transport system involved in multi-copper enzyme maturation, permease component,daunorubicin resistance ABC transporter membrane protein,ABC-2 family transporter protein) b3485(Predicted permease subunit, ABC transporter superfamily, inner membrane protein) BN373_03711(ABC-2 type transporter, permease protein) SL1344_3550(putative ABC-2 type superfamily transport protein) Cluster3723 0 1 1 1 1 0 0 ENC_35520(heavy metal response regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3439(Transcriptional regulatory protein CusR,DNA-binding transcriptional activator CusR,Response regulator of citrate/malate metabolism,heavy metal response regulator,Response regulator receiver domain) b0571(DNA-binding response regulator in two-component regulatory system with CusS) BN373_03651(transcriptional regulatory protein CusR) Cluster3724 1 0 0 0 1 1 1 ROD_16871(putative membrane protein) BN373_03601(putative membrane protein) t1535(putative membrane protein) SL1344_1562(putative membrane protein) Cluster3725 0 1 0 0 1 1 1 ENC_03060(Predicted transcriptional regulators) BN373_03581(transcriptional regulator, MerR family) t1258(putative transcriptional regulator) SL1344_1324(putative transcriptional regulator) Cluster3726 1 1 0 0 2 0 0 ROD_41141(putative maltoporin) ENC_03490(Maltoporin (phage lambda and maltose receptor)) BN373_03481(conserved hypothetical protein),BN373_47001(putative maltoporin) Cluster3727 1 1 1 0 1 0 0 ROD_22551(conserved hypothetical protein) ENC_07270(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.935(Pyocin large subunit) BN373_03261(conserved domain protein) Cluster3728 0 0 0 0 4 0 0 BN373_02891(conserved hypothetical protein),BN373_02901(conserved hypothetical protein),BN373_18281(putative transcriptional regulator (LysR familiy)),BN373_21006(transcriptional regulator (LysR family)) Cluster3729 1 0 1 1 1 0 0 ROD_33291(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4188(Ornithine/acetylornithine aminotransferase,Bacterial protein of unknown function (DUF853)) b4263(conserved protein, DUF853 family with NTPase fold) BN373_02851(conserved hypothetical protein) Cluster3730 0 1 0 0 1 1 1 ENC_43870(Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA) BN373_02781(tRNA-(MS[2]IO[6]A)-hydroxylase) t4505(tRNA hydroxylase) SL1344_4401(tRNA hydroxylase) Cluster3731 1 0 0 1 1 0 1 ROD_42961(fructoselysine kinase) b3374(fructoselysine 6-kinase) BN373_02711(PfkB domain protein) SL1344_3565(putative carbohydrate kinase) Cluster3732 1 0 0 1 1 0 1 ROD_29061(putative transcriptional regulator) b2847(predicted transcriptional regulator) BN373_01561(putative transcriptional regulatory protein) SL1344_3725(putative transcriptional regulator (MarT)) Cluster3733 0 1 1 1 1 0 0 ENC_32320(Predicted xylanase/chitin deacetylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2887(Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase precursor,outer membrane N-deacetylase,poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB,Polysaccharide deacetylase) b1023(biofilm adhesin polysaccharide PGA export lipoprotein with a polysaccharide deacetylase activity needed for export) BN373_01271(biofilm PGA synthesis lipoprotein PgaB) Cluster3734 0 1 1 1 1 0 0 ENC_32330(Glycosyltransferases, probably involved in cell wall biogenesis) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2888(Poly-beta-1,6-N-acetyl-D-glucosamine synthase,N-glycosyltransferase,Predicted glycosyl hydrolase,poly-beta-1,6 N-acetyl-D-glucosamine synthase,Glycosyl transferase family 2) b1022(predicted glycosyl transferase) BN373_01261(biofilm PGA synthesis N-glycosyltransferase PgaC) Cluster3735 0 1 0 0 1 1 1 ENC_36500(Protein-disulfide isomerase) BN373_01241(DSBA-like thioredoxin domain protein) t0029(putative exported protein) SL1344_0028(putative exported protein) Cluster3736 1 1 1 0 1 0 0 ROD_36821(putative prophage stability/partitioning protein) ENC_35730(plasmid segregation actin-type ATPase ParM) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3069(hypothetical protein,StbA protein) BN373_01191(plasmid segregation protein ParM) Cluster3737 0 0 0 1 1 1 1 b4120(melibiose:sodium symporter) BN373_01181(melibiose carrier protein) t4206(melibiose carrier protein) SL1344_4236(melibiose carrier protein) Cluster3738 0 1 1 1 1 0 0 ENC_05360(transcriptional regulator, GntR family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4363(Probable transcriptional regulator phnF,phosphonate metabolism transcriptional regulator PhnF,Transcriptional regulators,phosphonate metabolism transcriptional regulator PhnF,UTRA domain) b4102(predicted DNA-binding transcriptional regulator of phosphonate uptake and biodegradation) BN373_01121(phosphonates metabolism transcriptional regulator PhnF) Cluster3739 0 1 1 1 1 0 0 ENC_05350(phosphonate C-P lyase system protein PhnG) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4364(phosphonate C-P lyase system protein PhnG,Phosphonate metabolism protein PhnG) b4101(carbon-phosphorus lyase complex subunit) BN373_01111(phosphonate C-P lyase system protein PhnG) Cluster3740 0 1 1 1 1 0 0 ENC_05340(phosphonate C-P lyase system protein PhnH) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4365(hypothetical protein,carbon-phosphorus lyase complex subunit,phosphonate C-P lyase system protein PhnH,Bacterial phosphonate metabolism protein (PhnH)) b4100(carbon-phosphorus lyase complex subunit) BN373_01101(phosphonate C-P lyase system protein PhnH) Cluster3741 0 1 1 1 1 0 0 ENC_05330(Uncharacterized enzyme of phosphonate metabolism) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4366(Bacterial phosphonate metabolism protein (PhnI)) b4099(carbon-phosphorus lyase complex subunit) BN373_01091(bacterial phosphonate metabolism protein (PhnI)) Cluster3742 0 1 1 1 1 0 0 ENC_05320(Uncharacterized enzyme of phosphonate metabolism) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4367(Phosphonate metabolism protein PhnJ) b4098(carbon-phosphorus lyase complex subunit) BN373_01081(phosphonate metabolism protein PhnJ) Cluster3743 0 1 1 1 1 0 0 ENC_05310(phosphonate C-P lyase system protein PhnK) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4368(Glutathione import ATP-binding protein GsiA,phosphonate C-P lyase system protein PhnK,ABC-type oligopeptide transport system, ATPase component,phosphonate C-P lyase system protein PhnK,ABC transporter) b4097(carbon-phosphorus lyase complex subunit) BN373_01071(phosphonate C-P lyase system protein PhnK) Cluster3744 0 1 1 1 1 0 0 ENC_05300(phosphonate C-P lyase system protein PhnL) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4369(Lipoprotein-releasing system ATP-binding protein LolD,glutamine ABC transporter ATP-binding protein,ABC-type phosphonate transport system, ATPase component,phosphonate C-P lyase system protein PhnL,ABC transporter) b4096(carbon-phosphorus lyase complex subunit) BN373_01061(phosphonate C-P lyase system protein PhnL) Cluster3745 0 1 1 1 1 0 0 ENC_05290(phosphonate metabolism protein PhnM) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4370(phosphonate metabolism protein PhnM,Metal-dependent hydrolase involved in phosphonate metabolism,phosphonate metabolism protein PhnM,Amidohydrolase family) b4095(carbon-phosphorus lyase complex subunit) BN373_01051(phosphonate metabolism protein PhnM) Cluster3746 0 1 1 1 1 0 0 ENC_05280(phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4371(Ribose 1,5-bisphosphate phosphokinase PhnN,ribose 1,5-bisphosphokinase,Uncharacterized component of phosphonate metabolism,phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN,Guanylate kinase) b4094(ribose 1,5-bisphosphokinase) BN373_01041(phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN) Cluster3747 0 1 1 1 1 0 0 ENC_05260(phosphonate metabolism protein PhnP) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4373(hypothetical protein,carbon-phosphorus lyase complex accessory protein,phosphonate metabolism protein PhnP,Beta-lactamase superfamily domain) b4092(carbon-phosphorus lyase complex accessory protein, phosphodiesterase) BN373_01031(phosphonate utilization protein) Cluster3748 1 0 0 0 1 1 1 ROD_18141(putative fimbrial subunit) BN373_00831(fimbrial protein) t4631(putative fimbrial subunit) SL1344_4519(putative fimbrial subunit) Cluster3749 1 1 0 0 1 0 1 ROD_37301(putative Na+-dependent transporter) ENC_04540(Predicted Na+-dependent transporter) BN373_00181(sodium/bile acid symporter family protein) SL1344_4130(hypothetical protein) Cluster3750 0 0 0 3 0 0 0 b0246(CP4-6 prophage; antitoxin of the YkfI-YafW toxin-antitoxin system),b2645(CP4-57 prophage; antitoxin of the YpjF-YfjZ toxin-antitoxin system),pseudob0266(unknown) Cluster3751 0 0 0 3 0 0 0 b0018(regulatory protein for HokC, overlaps CDS of hokC),b1562(Qin prophage; small toxic polypeptide),b4412(toxic membrane protein, small) Cluster3752 0 0 0 3 0 0 0 b0016(IS186 transposase),b0582(IS186 transposase),b2394(IS186 transposase) Cluster3753 0 0 0 1 0 1 1 b4350(endonuclease R Type I restriction enzyme) t4576(subunit R of type I restriction-modification system) SL1344_4457(type III restriction enzyme) Cluster3754 0 0 0 1 0 1 1 b4264(DNA-binding transcriptional repressor, 5-gluconate-binding) t4515(regulatory protein) SL1344_4411(regulatory protein) Cluster3755 1 0 0 0 0 1 1 pseudoROD_36451(conserved hypothetical protein (pseudogene)) t4148(putative exported protein) SL1344_4178(putative exported protein) Cluster3756 0 0 0 1 0 1 1 b3220(conserved protein) t3249(conserved hypothetical protein) SL1344_3304(conserved hypothetical protein) Cluster3757 0 0 0 1 0 1 1 b2851(predicted chaperone) t2788(unknown function) SL1344_2865(type III secretion-associated chaperone) Cluster3758 0 0 0 1 0 1 1 pseudob2858(unknown) t2771(oxygen-regulated invasion protein) SL1344_2849(oxygen-regulated invasion protein) Cluster3759 0 0 0 1 0 1 1 b4066(pentapeptide repeat protein) t2674(conserved hypothetical protein) SL1344_2763(exported protein) Cluster3760 0 0 0 0 0 2 1 t3409(DNA adenine methylase),t4329(DNA adenine methylase) SL1344_2702(DNA adenine methylase) Cluster3761 0 0 0 0 0 2 1 t2662(putative bacteriophage tail protein),t3442(hypothetical protein) SL1344_2668(predicted bacteriophage protein) Cluster3762 0 0 0 1 0 1 1 b2269(protease, capable of cleaving an AMC-ubiquitin model substrate) t0576(conserved hypothetical protein) SL1344_2256(conserved hypothetical protein) Cluster3763 0 0 0 1 0 1 1 pseudob2238(unknown) t0583(putative transcriptional regulator) SL1344_2250(putative transcriptional regulator) Cluster3764 0 0 0 1 0 1 1 b1552(Qin prophage; cold shock protein) t0882(cold shock protein) SL1344_1924(cold shock protein) Cluster3765 0 0 0 1 0 1 1 b1824(predicted protein) t1040(conserved hypothetical protein) SL1344_1767(conserved hypothetical protein) Cluster3766 1 0 0 0 0 1 1 pseudoROD_16201(putative virulence protein (pseudogene)) t1208(putative outer membrane protein) SL1344_1263(putative outer membrane protein) Cluster3767 0 0 0 1 0 1 1 b1974(cytochrome b561 homolog) t1131(putative cytochrome) SL1344_1189(putative cytochrome) Cluster3768 0 0 0 1 0 1 1 b0989(stress protein, member of the CspA-family) t1115(putative cold shock protein) SL1344_1182(cold shock protein (CspH)) Cluster3769 0 0 0 1 0 1 1 b4280(predicted oxidoreductase) t1787(putative oxidoreductase) SL1344_1071(putative oxidoreductase) Cluster3770 0 0 0 1 0 1 1 b4279(predicted transporter) t1788(putative transporter) SL1344_1070(putative transporter) Cluster3771 0 0 0 0 0 0 3 SL1344_0965A(Gifsy-2 bacteriophage holin),SL1344_1957(putative bacteriophage holin),SL1344_2213(bacteriophage holin, lambda family) Cluster3772 0 0 0 1 0 1 1 b1359(Rac prophage; conserved protein) t1918(conserved hypothetical bacteriophage protein) SL1344_0952(Gifsy-2 replication Protein O) Cluster3773 0 0 0 0 0 1 2 t1927(putative bacteriophage protein) SL1344_0944(predicted bacteriophage protein),SL1344_2598(predicted bacteriophage protein) Cluster3774 0 0 0 1 0 1 1 b0303(predicted protein) t2297(hypothetical secreted protein) SL1344_0553(hypothetical secreted protein) Cluster3775 0 0 0 1 0 1 1 b2350(CPS-53 (KpLE1) prophage; bactoprenol-linked glucose translocase (flippase)) t2303(bactoprenol-linked glucose translocase) SL1344_0549(bactoprenol-linked glucose translocase) Cluster3776 0 0 0 1 0 1 1 b0533(predicted fimbrial-like adhesin protein) t2316(FimH protein precursor) SL1344_0540(FimH protein precursor) Cluster3777 0 0 0 0 0 2 1 t0019(hypothetical protein),t0020(hypothetical protein) SL1344_0019(putative chitinase) Cluster3778 1 0 0 0 0 1 1 ROD_50701(Major Facilitator Superfamily transporter) t2340(probable metabolite transport protein) SL1344_0513(probable metabolite transport protein) Cluster3779 1 0 0 0 0 1 1 ROD_50001(putative virulence-related outer membrane protein) t1119(outer membrane invasion protein) SL1344_1184(outer membrane invasion protein (PagC)) Cluster3780 1 0 0 0 0 1 1 ROD_48071(methyl-accepting chemotaxis protein II) t3136(methyl-accepting chemotaxis protein II) SL1344_3189(methyl-accepting chemotaxis protein II) Cluster3781 1 0 0 0 0 1 1 ROD_43741(Phage/plasmid maintenance protein) t1909(putative bacteriophage protein) SL1344_3524(death on curing protein) Cluster3782 1 0 0 0 0 1 1 ROD_43101(hypothetical protein) t4467(hypothetical protein) SL1344_4346(hypothetical protein) Cluster3783 1 0 0 0 0 1 1 ROD_43091(putative sigma-54 dependent transcriptional regulator) t2215(putative sigma-54 dependent transcriptional regulator) SL1344_0640(putative sigma-54 dependent transcriptional regulator) Cluster3784 1 0 0 0 0 1 1 ROD_42481(putative exported protein) t3869(putative exported protein) SL1344_3616(conserved hypothetical protein) Cluster3785 1 0 0 0 0 1 1 ROD_42121(putative LacI-family transcriptional regulator) t3823(putative lacI family transcriptional regulator) SL1344_3661(putative lacI family transcriptional regulator regulator) Cluster3786 1 0 0 0 0 1 1 ROD_42111(putative racemase) t3822(putative racemase) SL1344_3662(putative racemase) Cluster3787 1 0 0 0 0 1 1 ROD_41951(lipid A-core:O-antigen ligase) t3806(O-antigen ligase) SL1344_3679(O-antigen ligase) Cluster3788 3 0 0 0 0 0 0 ROD_40971(putative T3SS effector protein NleG8),ROD_48891(putative T3SS effector protein NleG7),pseudoROD_31781(putative T3SS effector protein NleG (pseudogene)) Cluster3789 1 0 0 0 0 1 1 ROD_40521(probable arylsulfatase-activating protein) t0038(possible sulfatase regulatory protein) SL1344_0037(possible sulfatase regulatory protein) Cluster3790 1 0 0 1 0 0 1 ROD_37281(conserved hypothetical protein) b3421(conserved protein) SL1344_3486(hypothetical protein) Cluster3791 1 0 0 0 0 1 1 ROD_36991(phage integrase) t4338(phage integrase) SL1344_2709(bacteriophage integrase) Cluster3792 1 0 0 0 0 1 1 ROD_36431(conserved hypothetical protein) t3392(conserved hypothetical protein) SL1344_3866(conserved hypothetical protein) Cluster3793 1 0 0 0 0 1 1 ROD_36331(conserved hypothetical protein) t4158(hypothetical protein) SL1344_4188(hypothetical protein) Cluster3794 1 0 0 0 0 1 1 ROD_36321(putative lipoprotein) t4159(putative lipoprotein) SL1344_4189(putative lipoprotein) Cluster3795 1 0 0 0 0 1 1 ROD_35521(conserved hypothetical protein) t3076(hypothetical protein) SL1344_3130(hypothetical protein) Cluster3796 1 0 0 0 0 1 1 ROD_35511(conserved hypothetical protein) t3075(hypothetical protein) SL1344_3129(hypothetical protein) Cluster3797 1 0 0 0 0 1 1 ROD_34941(conserved hypothetical protein) t4215(conserved hypothetical protein) SL1344_4245(conserved hypothetical protein) Cluster3798 1 0 0 0 0 1 1 ROD_34931(putative dimethyl sulfoxide reductase subunit C) t4214(putative dimethyl sulfoxide reductase subunit C) SL1344_4244(putative dimethyl sulfoxide reductase subunit C) Cluster3799 1 0 0 0 0 1 1 ROD_34191(Hcp family T6SS protein Cts2H) t3052(conserved hypothetical protein) SL1344_3105(conserved hypothetical protein) Cluster3800 1 0 0 0 0 1 1 ROD_32591(putative membrane protein) t4446(putative membrane protein) SL1344_4328(putative membrane protein) Cluster3801 1 0 0 0 0 1 1 ROD_30471(CRISPR-associated protein) t2843(hypothetical protein) SL1344_2921(hypothetical protein) Cluster3802 1 0 0 0 0 1 1 ROD_30101(T3SS structural protein EscR) t1287(putative type III secretion protein) SL1344_1353(putative type III secretion protein) Cluster3803 1 0 0 0 0 1 1 ROD_30091(T3SS structural protein EscT) t1289(putative type III secretion protein) SL1344_1355(putative type III secretion protein) Cluster3804 1 0 0 0 0 1 1 ROD_30081(T3SS structural protein EscU) t1290(putative type III secretion protein) SL1344_1356(putative type III secretion protein) Cluster3805 1 0 0 0 0 1 1 ROD_30051(GrlA, global regulator of LEE activator) t2936(hypothetical protein) SL1344_3004(hypothetical protein) Cluster3806 1 0 0 0 0 1 1 ROD_30011(T3SS chaperone CesD) t1267(putative type III secretion system chaperone protein) SL1344_1333(Type III secretion system chaperone protein) Cluster3807 1 0 0 0 0 1 1 ROD_30001(T3SS structural protein EscC) t1262(putative outer membrane secretory protein) SL1344_1328(putative outer membrane secretory protein) Cluster3808 1 0 0 0 0 1 1 ROD_29981(T3SS structural protein EscJ) t1277(putative pathogenicity island lipoprotein) SL1344_1343(putative pathogenicity island lipoprotein) Cluster3809 1 0 0 0 0 1 1 ROD_29941(T3SS structural protein EscV) t1282(putative type III secretion protein) SL1344_1348(putative type III secretion protein) Cluster3810 1 0 0 0 0 1 1 ROD_29931(T3SS translocator EscN) t1283(putative type III secretion ATP synthase) SL1344_1349(type III secretion ATP synthase) Cluster3811 1 0 0 0 0 1 1 ROD_29841(T3SS chaperone CesT) t0719(conserved hypothetical protein) SL1344_2114(conserved hypothetical protein) Cluster3812 1 0 0 0 0 1 1 ROD_29781(T3SS structural protein EscD) t1263(putative pathogenicity island protein) SL1344_1329(putative pathogenicity island protein) Cluster3813 1 0 0 0 0 1 1 ROD_29771(T3SS secretion switching protein SepL) t1280(putative secretion system protein) SL1344_1346(putative secretion system protein) Cluster3814 1 0 0 0 0 1 1 ROD_29761(T3SS translocator protein EspA) t1266(putative pathogenicity island effector protein) SL1344_1332(putative pathogenicity island effector effector protein) Cluster3815 1 0 0 0 0 1 1 ROD_29721(T3SS structural protein EscF) t1274(putative pathogenicity island protein) SL1344_1340(putative pathogenicity island protein) Cluster3816 1 0 0 0 0 1 1 ROD_29391(putative fimbrial adhesin) t2524(putative fimbrial protein) SL1344_0332(putative fimbrial protein) Cluster3817 1 0 0 0 0 1 1 ROD_29341(putative transmembrane regulator) t2520(possible transmembrane regulator) SL1344_0336(possible transmembrane regulator) Cluster3818 1 0 0 0 0 1 1 ROD_29331(Exported protein) t2519(hypothetical protein) SL1344_0337(putative periplasmic protein) Cluster3819 1 0 0 0 0 1 1 ROD_29311(putative transmembrane regulator) t2517(possible transmembrane regulator) SL1344_0339(possible transmembrane regulator) Cluster3820 1 0 0 0 0 1 1 ROD_29301(putative exported protein) t2516(hypothetical protein) SL1344_0340(hypothetical protein) Cluster3821 1 0 0 0 0 1 1 ROD_29291(putative outer membrane virulence protein) t2515(possible outer membrane protein) SL1344_0341(possible outer membrane protein) Cluster3822 1 0 0 0 0 1 1 ROD_29271(putative lipoprotein) t2512(probable lipoprotein) SL1344_0344(probable lipoprotein) Cluster3823 1 0 0 0 0 1 1 ROD_27651(ImpE family T6SS protein Cts1E) t2594(hypothetical protein) SL1344_0264(conserved hypothetical protein (SPI-6 associated)) Cluster3824 3 0 0 0 0 0 0 ROD_26401(lymphocyte inhibitory factor A),ROD_31811(LifA-like protein),ROD_47771(LifA-like protein) Cluster3825 1 0 0 1 0 0 1 ROD_26251(hypothetical prophage protein) b2361(CPS-53 (KpLE1) prophage; conserved protein) SL1344_1970(predicted bacteriophage protein) Cluster3826 1 0 0 1 0 0 1 ROD_26241(hypothetical prophage protein) b2360(CPS-53 (KpLE1) prophage; predicted protein) SL1344_1969(predicted bacteriophage protein) Cluster3827 1 0 0 1 0 0 1 ROD_26231(hypothetical prophage protein) b2359(CPS-53 (KpLE1) prophage; predicted protein) SL1344_1968(predicted bacteriophage protein) Cluster3828 1 0 0 1 0 0 1 ROD_26161(putative prophage DNA adenine methylase) pseudob2356(unknown) SL1344_1962(predicted bacteriophage protein) Cluster3829 2 0 0 0 0 0 1 ROD_25821(hypothetical prophage protein),ROD_47341(hypothetical prophage protein) SL1344_1934(predicted bacteriophage protein) Cluster3830 1 0 0 1 0 0 1 ROD_25801(putative phage tail protein) b1153(prohage e14 tail protein homolog) SL1344_1931(putative bacteriophage tail protein) Cluster3831 1 0 0 0 0 1 1 ROD_25701(large repetitive protein) t2643(large repetitive protein) SL1344_2661(large repetitive protein) Cluster3832 1 0 0 0 0 1 1 ROD_22681(putative transcriptional regulator) t0675(putative transcriptional regulator) SL1344_2157(putative transcriptional regulator) Cluster3833 1 0 0 0 0 1 1 ROD_22661(putative gentisate 1,2-dioxygenase) t0677(putative gentisate 1,2-dioxygenase) SL1344_2155(putative gentisate 1,2-dioxygenase) Cluster3834 1 0 0 0 0 1 1 ROD_22651(FAA-hydrolase-family protein) t0678(FAA-hydrolase-family protein) SL1344_2154(FAA-hydrolase-family protein) Cluster3835 1 0 0 0 0 1 1 ROD_22641(glutathione-S-transferase-family protein) t0679(glutathione-S-transferase-family protein) SL1344_2153(glutathione-S-transferase-family protein) Cluster3836 1 0 0 0 0 1 1 ROD_20781(hypothetical protein) t0860(hypothetical protein) SL1344_1989(hypothetical protein) Cluster3837 2 0 0 0 0 1 0 ROD_16511(putative T3SS effector protein NleG1),pseudoROD_31761(putative T3SS effector protein NleG2 (pseudogene)) t1865(conserved hypothetical protein) Cluster3838 1 0 0 1 0 0 1 ROD_16161(methyl-accepting chemotaxis protein III (ribose an galactose chemoreceptor protein)) b1421(methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor) SL1344_1556(methyl-accepting chemotaxis protein III (mcp-iii) (ribose and galactose chemoreceptor protein)) Cluster3839 1 0 0 0 0 1 1 ROD_15861(putative virulence effector protein) t1503(putative virulence effector protein) SL1344_1524(putative virulence effector protein) Cluster3840 1 0 0 0 0 1 1 ROD_15431(putative hydrolase) t1472(putative hydrolase) SL1344_1489(putative hydrolase) Cluster3841 1 0 0 0 0 1 1 ROD_15411(putative exported protein) t1474(putative secreted protein) SL1344_1491(putative exported protein) Cluster3842 1 0 0 0 0 1 1 ROD_13591(putative Rhs protein) t2569(Rhs-family protein) SL1344_0286(Rhs-family protein (SPI-6 associated)) Cluster3843 1 0 0 0 0 1 1 ROD_12561(putative outer membrane protein) t1151(putative membrane protein) SL1344_1208(putative membrane protein) Cluster3844 1 0 0 0 0 1 1 ROD_12341(conserved hypothetical protein) t1139(conserved hypothetical protein) SL1344_1197(conserved hypothetical protein) Cluster3845 1 0 0 1 0 0 1 ROD_12071(putative T3SS effector protein EspX7) pseudob4038(unknown) SL1344_2043(secreted protein SopA) Cluster3846 3 0 0 0 0 0 0 ROD_12061(putative tail fibre protein),pseudoROD_16501(putative tail fibre protein (fragment)),pseudoROD_31741(putative tail fibre protein (pseudogene)) Cluster3847 1 0 0 0 0 1 1 ROD_11981(conserved hypothetical protein) t3883(hypothetical protein) SL1344_3598(conserved hypothetical protein) Cluster3848 1 0 0 0 0 1 1 ROD_08691(putative sulfatase) t2010(probable sulfatase) SL1344_0862(probable sulfatase) Cluster3849 1 0 0 0 0 1 1 ROD_08681(putative phosphotransferase enzyme II, B component) t2011(putative phosphotransferase enzyme II, B component) SL1344_0861(putative phosphotransferase enzyme II, B component) Cluster3850 1 0 0 0 0 1 1 ROD_08671(possible transport protein) t2012(possible transport protein) SL1344_0860(possible transport protein) Cluster3851 1 0 0 0 0 1 1 ROD_08301(conserved hypothetical protein) t3752(conserved hypothetical protein) SL1344_3731(conserved hypothetical protein) Cluster3852 1 0 0 0 0 1 1 ROD_06901(lysR-family transcriptional regulator) t2183(lysR-family transcriptional regulator) SL1344_0674(lysR-family transcriptional regulator) Cluster3853 1 0 0 0 0 1 1 ROD_06891(conserved hypothetical protein) t2184(conserved hypothetical protein) SL1344_0673(conserved hypothetical protein) Cluster3854 1 0 0 0 0 1 1 ROD_06881(citrate utilisation protein B) t2185(citrate utilization protein B) SL1344_0672(citrate utilization protein B) Cluster3855 2 0 0 0 0 1 0 ROD_02671(putative phage lysozyme),ROD_36701(putative phage lysozyme) t1109(conserved hypothetical protein) Cluster3856 3 0 0 0 0 0 0 ROD_02581(hypothetical prophage protein),ROD_47201(putative prophage protease protein),ROD_47211(phage scaffold protein) Cluster3857 1 0 0 0 0 1 1 ROD_00661(conserved hypothetical protein) t0104(hypothetical protein) SL1344_0100(hypothetical protein) Cluster3858 1 0 0 0 0 1 1 ROD_00141(conserved hypothetical protein) t0017(putative membrane protein) SL1344_0017(putative membrane protein) Cluster3859 1 0 0 0 0 1 1 ROD_00131(conserved hypothetical protein) t0016(conserved hypothetical protein) SL1344_0016(conserved hypothetical protein) Cluster3860 1 0 0 0 0 1 1 ROD_00122(conserved hypothetical protein) t0015(putative phage protein) SL1344_0015(predicted bacteriophage protein) Cluster3861 1 0 0 0 0 1 1 ROD_00121(putative LysR-family transcriptional regulator) t0014(putative regulatory protein) SL1344_0014(putative regulatory protein) Cluster3862 1 0 1 1 0 0 0 ROD_49691(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.18(Protein of unknown function (DUF987)) b2003(CP4-44 prophage; predicted protein) Cluster3863 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.48(CAAX amino terminal protease self- immunity) t0487(conserved hypothetical protein) SL1344_2346(conserved hypothetical protein) Cluster3864 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.41(Tetracycline resistance protein, class C,bicyclomycin/multidrug efflux system,Arabinose efflux permease,multidrug resistance protein,Major Facilitator Superfamily) t1464(putative multidrug efflux protein) SL1344_1474(putative multidrug efflux protein) Cluster3865 0 0 3 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.24(Methyl viologen resistance protein C,multidrug efflux protein,Membrane transporters of cations and cationic drugs,Small Multidrug Resistance protein),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.5(Methyl viologen resistance protein C,multidrug efflux protein,Membrane transporters of cations and cationic drugs,Small Multidrug Resistance protein),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.6(Methyl viologen resistance protein C,multidrug efflux protein,Membrane transporters of cations and cationic drugs,Small Multidrug Resistance protein) Cluster3866 0 0 3 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.188(Dihydrofolate reductase type 1,dihydrofolate reductase,Dihydrofolate reductase),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.26(Dihydrofolate reductase type 1,dihydrofolate reductase,Dihydrofolate reductase),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.7(Dihydrofolate reductase type 1,dihydrofolate reductase,Dihydrofolate reductase) Cluster3867 0 0 3 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.184(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.22(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.3(hypothetical protein) Cluster3868 0 0 3 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.182(lineage-specific thermal regulator protein,transcriptional regulator, Acidobacterial, PadR-family,Transcriptional regulator PadR-like family),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.20(lineage-specific thermal regulator protein,transcriptional regulator, Acidobacterial, PadR-family,Transcriptional regulator PadR-like family),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.3(lineage-specific thermal regulator protein,transcriptional regulator, Acidobacterial, PadR-family,Transcriptional regulator PadR-like family) Cluster3869 0 0 3 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.16(Aminoglycoside phosphotransferase,Phosphotransferase enzyme family),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.178(Aminoglycoside phosphotransferase,Phosphotransferase enzyme family),Escherichia_coli_UPEC_ST131_v0.1_7_5301569-5316108.21(hypothetical protein) Cluster3870 2 0 1 0 0 0 0 ROD_27211(putative membrane protein),ROD_42321(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.98(Inner membrane symporter yicJ,putative symporter YagG,sugar (Glycoside-Pentoside-Hexuronide) transporter,Major Facilitator Superfamily) Cluster3871 1 0 1 1 0 0 0 ROD_33881(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.889(4-hydroxybenzoyl-CoA reductase subunit alpha,xanthine dehydrogenase subunit XdhA,Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs,4-hydroxybenzoyl-CoA reductase, alpha subunit,Molybdopterin-binding domain of aldehyde dehydrogenase) b2866(xanthine dehydrogenase, molybdenum binding subunit) Cluster3872 1 0 1 1 0 0 0 ROD_33891(putative iron-sulfur binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.887(Nicotinate dehydrogenase small FeS subunit,xanthine dehydrogenase subunit XdhC,Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs,xanthine dehydrogenase E subunit,[2Fe-2S] binding domain) b2868(xanthine dehydrogenase, Fe-S binding subunit) Cluster3873 1 0 1 1 0 0 0 ROD_34041(transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.886((S)-limonene 6-monooxygenase,anaerobic nitric oxide reductase transcription regulator,Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,nitrogen regulation protein NR(I),Sigma-54 interaction domain) b2869(predicted DNA-binding transcriptional regulator) Cluster3874 1 0 1 1 0 0 0 ROD_34031(putative aspartate/ornithine carbamoyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.885(hypothetical protein,aspartate/ornithine carbamoyltransferase family protein,Ornithine carbamoyltransferase,putative carbamoyltransferase YgeW,Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain) b2870(predicted carbamoyltransferase) Cluster3875 1 0 1 1 0 0 0 ROD_34011(putative peptidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.883(Acetylornithine deacetylase,peptidase,putative selenium metabolism hydrolase,Peptidase family M20/M25/M40) b2872(predicted peptidase) Cluster3876 1 0 1 1 0 0 0 ROD_34001(putative hydantoinase (amidohydrolase)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.882(D-phenylhydantoinase,phenylhydantoinase,N-acyl-D- aspartate/D-glutamate deacylase,dihydropyrimidinase,Amidohydrolase family) b2873(D-stereospecific phenylhydantoinase) Cluster3877 1 0 1 1 0 0 0 ROD_33991(carbamate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.881(Carbamate kinase 1,putative amino acid kinase,Acetylglutamate kinase,carbamate kinase,Amino acid kinase family) b2874(predicted amino acid kinase) Cluster3878 1 0 1 1 0 0 0 ROD_33981(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.880(selenium-dependent molybdenum hydroxylase system protein, YqeB family,XdhC and CoxI family) b2875(conserved protein with NAD(P)-binding Rossman fold) Cluster3879 1 0 1 1 0 0 0 ROD_33901(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.878(molybdopterin-guanine dinucleotide biosynthesis protein A,CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes,molybdenum hydroxylase accessory protein, YgfJ family,MobA-like NTP transferase domain) b2877(CTP:molybdopterin cytidylyltransferase) Cluster3880 1 0 1 1 0 0 0 ROD_33961(pyridine nucleotide-disulfide oxidoreductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.877(Glutamate synthase [NADPH] small chain,putative selenate reductase subunit YgfK,Protoporphyrinogen oxidase,putative selenate reductase, YgfK subunit,Pyridine nucleotide-disulphide oxidoreductase) b2878(predicted oxidoreductase, Fe-S subunit) Cluster3881 1 0 1 1 0 0 0 ROD_33941(putative oxidoreductase, 4Fe-4S subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.870(Electron transport protein hydN,putative oxidoreductase Fe-S binding subunit,Uncharacterized Fe-S center protein,dimethylsulfoxide reductase, chain B,4Fe-4S dicluster domain) b2886(predicted oxidoreductase, 4Fe-4S ferredoxin-type subunit) Cluster3882 1 0 1 1 0 0 0 ROD_33921(putative permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.868(Putative purine permease ygfU,uracil transporter,xanthine permease,Permease family) b2888(predicted transporter) Cluster3883 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.83(hypothetical protein) t3829(putative lipoprotein) SL1344_3655(putative lipoprotein) Cluster3884 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.828(Predicted DNA-binding protein with PD1-like DNA-binding motif,Domain of unknown function (DUF296)) t2990(conserved hypothetical protein) SL1344_3047(conserved hypothetical protein) Cluster3885 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.827(Protein of unknown function (DUF3816)) t2991(putative membrane protein) SL1344_3048(putative membrane protein) Cluster3886 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.826(ABC-type cobalt transport system, permease component CbiQ and related transporters) t2992(putative membrane protein) SL1344_3049(putative membrane protein) Cluster3887 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.825(Energy-coupling factor transporter ATP-binding protein EcfA1,cobalt transporter ATP-binding subunit,ABC-type spermidine/putrescine transport systems, ATPase components,cobalt ABC transporter, ATP-binding protein,ABC transporter) t2993(possible ABC-transport protein, ATP-binding component) SL1344_3050(possible ABC-transport protein, ATP-binding component) Cluster3888 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.824(Energy-coupling factor transporter ATP-binding protein EcfA1,cobalt transporter ATP-binding subunit,ABC-type spermidine/putrescine transport systems, ATPase components,cobalt ABC transporter, ATP-binding protein,ABC transporter) t2994(possible ABC-transport protein, ATP-binding component) SL1344_3051(possible ABC-transport protein, ATP-binding component) Cluster3889 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.795(2,3-diketo-L-gulonate TRAP transporter small permease protein yiaM,2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM,TRAP-type C4-dicarboxylate transport system, small permease component,Tripartite ATP-independent periplasmic transporters, DctQ component) t3566(possible membrane transport protein) SL1344_4002(trap dicarboxylate transporter, dctq subunit) Cluster3890 1 0 1 1 0 0 0 ROD_36051(LysR-family transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.633(D-malate degradation protein R,transcriptional activator TtdR,ABC-type uncharacterized transport system, periplasmic component,putative choline sulfate-utilization transcription factor,LysR substrate binding domain) b3060(transcriptional activator of ttdABT) Cluster3891 1 0 1 1 0 0 0 ROD_41881(lipopolysaccharide core biosynthesis protein RfaS) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.56(hypothetical protein) b3629(lipopolysaccharide core biosynthesis protein) Cluster3892 0 0 2 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4913(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.8(hypothetical protein) SL1344_4425(putative ATPase) Cluster3893 0 0 2 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4907(conserved hypothetical protein,PglZ domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.6(conserved hypothetical protein,PglZ domain) SL1344_4421(conserved hypothetical protein) Cluster3894 0 0 2 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4906(Lon protease,DNA-binding ATP-dependent protease La,conserved hypothetical protein,Lon protease (S16) C-terminal proteolytic domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.5(conserved hypothetical protein) SL1344_4420(putative ATP-dependent Lon protease) Cluster3895 0 0 2 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4896(Transposase and inactivated derivatives,Transposase IS66 family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4898(Transposase and inactivated derivatives,putative Helix-turn-helix domain of transposase IS66) pseudob4640(unknown) Cluster3896 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4892(hypothetical protein,putative pilin structural protein SafD,Enterobacteria AfaD invasin protein) t2557(putative fimbrial structural subunit) SL1344_0298(fimbrial structural subunit) Cluster3897 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4890(Capsule protein fraction 1,pili assembly chaperone protein SafB,Gram-negative pili assembly chaperone, N-terminal domain) t2559(periplasmic fimbrial chaperone protein) SL1344_0296(salmonella atypical fimbria chaperone) Cluster3898 1 0 2 0 0 0 0 pseudoROD_49851(conserved hypothetical protein (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4879(Protein of unknown function (DUF3279)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4905(Protein of unknown function (DUF3279)) Cluster3899 1 0 2 0 0 0 0 ROD_49791(puative transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4876(Predicted transcriptional regulator,Prophage CP4-57 regulatory protein (AlpA)),Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.29(Predicted transcriptional regulator,Prophage CP4-57 regulatory protein (AlpA)) Cluster3900 1 0 1 1 0 0 0 ROD_40481(putative sulfatase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4837(Arylsulfatase,arylsulfatase,Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily,choline-sulfatase,Sulfatase) b3678(predicted sulfatase/phosphatase) Cluster3901 1 0 1 1 0 0 0 ROD_40471(putative sodium:solute symporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4835(Uncharacterized symporter yidK,putative transporter,Predicted symporter,transporter, solute:sodium symporter (SSS) family,Sodium:solute symporter family) b3679(predicted transporter) Cluster3902 1 0 1 1 0 0 0 ROD_40461(AraC-family transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4834(L-rhamnose operon transcriptional activator rhaR,DNA-binding transcriptional regulator AraC,Adenosine deaminase,YSIRK-targeted surface antigen transcriptional regulator,Bacterial regulatory helix-turn-helix proteins, AraC family) b3680(predicted transcriptional regulator, AraC family) Cluster3903 1 0 1 1 0 0 0 ROD_40351(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4828(putative oxidoreductase,geranylgeranyl reductase family,FAD binding domain) b3690(predicted oxidoreductase with FAD/NAD(P)-binding domain) Cluster3904 0 0 1 1 0 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4822(hypothetical protein) b3696(predicted lipoproteinC) t3921(putative lipoprotein) Cluster3905 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4556(Uncharacterized protein conserved in bacteria,Domain of unknown function (DUF1287)) b3944(conserved protein) SL1344_4057(conserved hypothetical protein) Cluster3906 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.439(Glycerol-3-phosphate regulon repressor,DNA-binding transcriptional regulator AgaR,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,Bacterial regulatory proteins, deoR family) t3172(hypothetical protein) SL1344_3225(putative transcriptional repressor) Cluster3907 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.438(5-dehydro-2-deoxygluconokinase,aminoimidazole riboside kinase,Uncharacterized protein conserved in bacteria,ribokinase,pfkB family carbohydrate kinase) t3171(possible carbohydrate kinase) SL1344_3224(probable carbohydrate kinase) Cluster3908 1 0 1 1 0 0 0 ROD_34711(D-allose transporter permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4379(D-allose transport system permease protein AlsC,D-allose transporter subunit,Predicted ABC-type sugar transport system, permease component,Branched-chain amino acid transport system / permease component) b4086(D-allose transporter subunit) Cluster3909 1 0 1 1 0 0 0 ROD_41321(transcriptional regulator of virulence RegA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4334(Colonization factor antigen I subunit D,transcriptional regulator HilD,Response regulator containing a CheY-like receiver domain and a GGDEF domain,YSIRK-targeted surface antigen transcriptional regulator,Bacterial regulatory helix-turn-helix proteins, AraC family) b0564(DNA-binding global transcriptional activator; DLP12 prophage) Cluster3910 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4298(Inner membrane protein yjeO,Protein of unknown function (DUF2645)) b4158(inner membrane protein) SL1344_4283(exported protein) Cluster3911 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4274(PspA/IM30 family) b4182(conserved protein, PspA/IM30 family) pseudoSL1344_4304(conserved hypothetical protein (pseudogene)) Cluster3912 1 0 1 1 0 0 0 ROD_45461(Putative ABC transporter, substrate-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.426(Glutamate/aspartate periplasmic-binding protein precursor,glutamate and aspartate transporter subunit,lysine-arginine-ornithine-binding periplasmic protein,Bacterial extracellular solute-binding proteins, family 3) pseudob3268(unknown) Cluster3913 1 0 1 1 0 0 0 ROD_45451(ABC transporter, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.425(Inner membrane amino-acid ABC transporter permease protein yecS,glutamine ABC transporter permease protein,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuD,Binding-protein-dependent transport system inner membrane component) b3269(predicted amino-acid transporter subunit) Cluster3914 1 0 1 1 0 0 0 ROD_45431(ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.423(Arginine transport ATP-binding protein ArtM,glutamine ABC transporter ATP-binding protein,ABC-type histidine transport system, ATPase component,ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA,ABC transporter) b3271(predicted amino-acid transporter subunit) Cluster3915 1 0 1 1 0 0 0 ROD_32841(Antitoxin component of the ChpB-ChpS toxin-antitoxin system) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4225(Antitoxin ChpS,antitoxin ChpS,Growth regulator,SpoVT / AbrB like domain) b4224(antitoxin of the ChpBS toxin-antitoxin system) Cluster3916 1 0 1 1 0 0 0 ROD_32851(Toxin component of the ChpB-ChpS toxin-antitoxin system) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4224(mRNA interferase ChpB,toxin ChpB,PemK-like protein) b4225(toxin of the ChpB-ChpS toxin-antitoxin system) Cluster3917 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4169(hypothetical protein) t3727(hypothetical protein) SL1344_3757(hypothetical protein) Cluster3918 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4168(L-fucose permease,L-fucose transporter,L-fucose:H+ symporter permease,Major Facilitator Superfamily) t3726(probable permease) SL1344_3758(probable permease) Cluster3919 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4167(Ribokinase,ribokinase,Deoxyribose-phosphate aldolase,ribokinase,pfkB family carbohydrate kinase) t3725(putative carbohydrate kinase) SL1344_3759(putative carbohydrate kinase) Cluster3920 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4166(Deoxyribose operon repressor,DNA-binding transcriptional repressor DeoR,Bacterial regulatory proteins, deoR family) t3724(putative DeoR-family transcriptional regulator) SL1344_3760(putative DeoR-family transcriptional regulator) Cluster3921 2 0 1 0 0 0 0 ROD_10871(hypothetical protein),ROD_49641(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4122(Enterobacterial protein of unknown function (DUF957)) Cluster3922 1 0 1 0 0 0 1 ROD_48801(IS3 family transposase A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4120(hypothetical protein) SL1344_0887(ISPsy11, transposase OrfA) Cluster3923 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4091(putative DNA helicase) pseudob4308(unknown) SL1344_4418(superfamily I DNA helicase) Cluster3924 2 0 1 0 0 0 0 ROD_38701(transposase),pseudoROD_05781(transposase (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4086(Transposase and inactivated derivatives,Transposase) Cluster3925 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4048(Uncharacterized protein conserved in bacteria) t4579(hypothetical protein) SL1344_4460(hypothetical protein) Cluster3926 1 0 1 1 0 0 0 ROD_48481(GntR-family transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4042(transcriptional regulator NanR,Transcriptional regulators,phosphonate utilization associated transcriptional regulator,Bacterial regulatory proteins, gntR family) b4357(DNA-binding transcriptional activator for yjjMN; mutants fail to grow on L-galactonate) Cluster3927 1 0 1 1 0 0 0 ROD_15321(putative DNA-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4012(putative DNA-binding transcriptional regulator,Uncharacterized protein related to capsule biosynthesis enzymes,HipA-like N-terminal domain) b4385(HipA family protein) Cluster3928 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3978(hypothetical protein,Nucleoside-specific channel-forming protein, Tsx) t0036(putative exported protein) SL1344_0035(putative exported protein) Cluster3929 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3977(Arylsulfatase precursor,arylsulfatase,Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily,choline-sulfatase,Sulfatase) t0037(putative secreted sulfatase) SL1344_0036(putative secreted sulfatase) Cluster3930 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3976(hypothetical protein) t0039(hypothetical protein) SL1344_0038(conserved hypothetical protein) Cluster3931 0 0 1 1 0 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3848(putative fimbrial-like adhesin protein,P pilus assembly protein, pilin FimA,Fimbrial protein) b0135(predicted fimbrial-like adhesin protein) t0184(putative fimbrial protein) Cluster3932 0 0 1 1 0 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3842(putative fimbrial protein StaA,P pilus assembly protein, pilin FimA,Fimbrial protein) b0141(predicted fimbrial-like adhesin protein) t0190(putative fimbrial protein) Cluster3933 1 0 1 1 0 0 0 ROD_02261(putative exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3756(Probable endopeptidase YafL precursor,outer membrane lipoprotein,NlpC/P60 family) b0227(predicted lipoprotein and C40 family peptidase) Cluster3934 1 0 1 1 0 0 0 ROD_02271(lateral flagellar export/assembly protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3754(Flagellar biosynthesis protein flhA,flagellar biosynthesis protein FlhA,Type III secretory pathway, component EscV,flagellar biosynthesis protein FlhA,FHIPEP family) pseudob0229(unknown) Cluster3935 1 0 1 1 0 0 0 ROD_45001(putative T2SS component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.374(protein secretion protein GspB) b3322(part of gsp divergon involved in type II protein secretion) Cluster3936 1 0 1 1 0 0 0 ROD_44991(putative T2SS protein A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.373(Putative general secretion pathway protein A,Putative peptidoglycan binding domain) b3323(general secretory pathway component, cryptic) Cluster3937 1 0 1 1 0 0 0 ROD_44981(putative T2SS protein C) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.372(Pectic enzymes secretion protein outC,putative type II secretion protein GspC,type II secretion system protein C) b3324(general secretory pathway component, cryptic) Cluster3938 1 0 1 1 0 0 0 ROD_03291(lateral flagellar motor protein B) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3709(Chemotaxis protein MotB,hypothetical protein,Uncharacterized protein conserved in bacteria,type VI secretion system OmpA/MotB family protein,OmpA family) pseudob0230(unknown) Cluster3939 1 0 2 0 0 0 0 ROD_34281(putative Type I restriction-modification system, restriction (R) subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3691(Type-1 restriction enzyme R protein,type I site-specific deoxyribonuclease, HsdR family,Type I restriction enzyme R protein N terminus (HSDR_N)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4053(Type-1 restriction enzyme R protein,type I site-specific deoxyribonuclease, HsdR family,Domain of unknown function (DUF3387)) Cluster3940 1 0 1 1 0 0 0 pseudoROD_40781(intimin-like protein (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3669(Invasin,intimin-like protein SinH,Predicted integral membrane protein linked to a cation pump,Protein of unknown function (DUF3442)) pseudob0297(unknown) Cluster3941 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3658(hypothetical protein) t2158(hypothetical protein) SL1344_0699(putative transport protein) Cluster3942 1 0 1 1 0 0 0 ROD_44911(putative T2SS protein J) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.365(PilD-dependent protein pddD,Type II secretory pathway, component PulJ,type II secretion system protein J,Pseudopilin GspJ) b3331(predicted general secretory pathway component, cryptic) Cluster3943 1 0 1 1 0 0 0 ROD_44881(putative T2SS protein M) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.362(General secretion pathway, M protein) b3334(general secretory pathway component, cryptic) Cluster3944 1 0 1 1 0 0 0 ROD_44811(putative polysaccharide degrading enzyme) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.358(Probable bifunctional chitinase/lysozyme precursor,Carbohydrate binding domain) b3338(periplasmic endochitinase) Cluster3945 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3474(Ureidoglycolate hydrolase,ureidoglycolate hydrolase,Allantoicase,Ureidoglycolate hydrolase) b0505(ureidoglycolate hydrolase) SL1344_0508(ureidoglycolate hydrolase) Cluster3946 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3353(Protein of unknown function (DUF1266)) b0648(conserved protein, DUF1266 family) pseudoSL1344_0645(putative conserved hypothetical protein (pseudogene)) Cluster3947 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3352(hypothetical protein) b0649(Hsc56 co-chaperone of HscC) SL1344_0647(unknown) Cluster3948 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3351(Hsc62,molecular chaperone DnaK,Ethanolamine utilization protein, possible chaperonin,Fe-S protein assembly chaperone HscA,Hsp70 protein) b0650(Hsp70 family chaperone Hsc62, binds to RpoD and inhibits transcription) SL1344_0648(chaperone heat shock protein) Cluster3949 1 0 1 1 0 0 0 ROD_07671(putative aconitase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3227(2,3-dimethylmalate dehydratase large subunit,putative hydratase,3-isopropylmalate dehydratase large subunit,putative aconitate hydratase,Aconitase family (aconitate hydratase)) b0771(predicted hydratase) Cluster3950 1 0 1 1 0 0 0 ROD_08291(fructose-6-phosphate aldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3174(Fructose-6-phosphate aldolase 1,fructose-6-phosphate aldolase,Transaldolase,fructose-6-phosphate aldolase,Transaldolase) b0825(fructose-6-phosphate aldolase 1) Cluster3951 1 0 2 0 0 0 0 ROD_19811(putative prophage host toxic membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3103(small toxic polypeptide,Hok/gef family),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.2(small toxic polypeptide,Hok/gef family) Cluster3952 1 0 2 0 0 0 0 ROD_36601(phage tail fibre assembly protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3093(Caudovirales tail fibre assembly protein),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.14(Caudovirales tail fibre assembly protein) Cluster3953 1 0 2 0 0 0 0 ROD_36711(putative phage holin) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3081(phage holin, lambda family,Phage holin family (Lysis protein S)),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.26(phage holin, lambda family,Phage holin family (Lysis protein S)) Cluster3954 2 0 1 0 0 0 0 ROD_19921(hypothetical prophage protein),ROD_36841(hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3067(hypothetical protein) Cluster3955 2 0 1 0 0 0 0 ROD_19981(hypothetical prophage protein),ROD_36911(hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3061(hypothetical protein) Cluster3956 2 0 1 0 0 0 0 ROD_20011(hypothetical prophage protein),ROD_36931(hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3058(hypothetical protein) Cluster3957 2 0 1 0 0 0 0 ROD_20021(hypothetical prophage protein),ROD_36941(hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3057(hypothetical protein) Cluster3958 1 0 1 0 0 1 0 ROD_09191(conserved hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3020(Mu-like prophage protein gp36,Protein of unknown function (DUF1320)) t1366(conserved bacteriophage hypothetical protein) Cluster3959 1 0 1 0 0 1 0 ROD_09201(conserved hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3019(hypothetical protein) t1367(putative membrane protein) Cluster3960 1 0 1 0 0 1 0 ROD_09211(conserved hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3018(hypothetical protein) t1368(hypothetical protein) Cluster3961 1 0 1 0 0 1 0 ROD_09221(conserved hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3017(hypothetical protein) t1369(hypothetical protein) Cluster3962 1 0 1 0 0 1 0 ROD_09231(conserved hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3016(Mu-like prophage protein gpG,phage virion morphogenesis protein,Phage virion morphogenesis family) t1370(putative bacteriophage protein) Cluster3963 1 0 1 0 0 1 0 ROD_09241(putative phage head assembly protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3015(phage head morphogenesis protein, SPP1 gp7 family,Phage Mu protein F like protein) t1371(hypothetical protein) Cluster3964 1 0 1 0 0 1 0 ROD_09251(putative phage portal protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3014(Mu-like prophage protein gp29,Protein of unknown function (DUF935)) t1372(hypothetical protein) Cluster3965 1 0 1 0 0 1 0 ROD_09261(putative phage terminase large subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3013(Mu-like prophage FluMu protein gp28,Terminase-like family) t1373(conserved hypothetical protein) Cluster3966 1 0 1 0 0 1 0 ROD_09271(conserved hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3012(Protein of unknown function (DUF3486)) t1374(hypothetical protein) Cluster3967 1 0 1 0 0 1 0 ROD_09281(conserved hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3011(hypothetical protein) t1375(hypothetical protein) Cluster3968 1 0 1 0 0 1 0 ROD_09301(putative prophage membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3009(hypothetical protein) t1377(putative lipoprotein) Cluster3969 1 0 1 0 0 1 0 ROD_09381(conserved hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2999(hypothetical protein) t1382(hypothetical protein) Cluster3970 1 0 1 0 0 1 0 ROD_09391(putative phage transposase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2997(Integrase core domain) t1384(hypothetical protein) Cluster3971 1 0 1 0 0 1 0 ROD_09411(putative prophage exported protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2995(hypothetical protein) t1386(hypothetical protein) Cluster3972 1 0 1 0 0 1 0 ROD_46991(prophage host-nuclease inhibitor protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2994(Mu-like prophage host-nuclease inhibitor protein Gam,Bacteriophage Mu Gam like protein) t1387(bacteriophage host-nuclease inhibitor protein) Cluster3973 1 0 1 0 0 1 0 ROD_09431(hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2992(hypothetical protein) t1389(hypothetical protein) Cluster3974 1 0 1 0 0 1 0 ROD_09432(conserved hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2991(hypothetical protein) t1390(hypothetical protein) Cluster3975 1 0 1 0 0 1 0 ROD_09441(conserved hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2989(Protein of unknown function (DUF2786)) t1393(hypothetical protein) Cluster3976 1 0 1 0 0 1 0 ROD_09442(putative prophage membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2987(hypothetical protein) t1395(hypothetical protein) Cluster3977 1 0 1 0 0 1 0 ROD_09451(putative prophage regulatory protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2986(Mu-like prophage protein gp16,Protein of unknown function (DUF1018)) t1396(conserved hypothetical protein) Cluster3978 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2920(hypothetical protein,hypothetical protein,Membrane bound YbgT-like protein) b4592(hypothetical protein) SL1344_1722(conserved hypothetical protein) Cluster3979 1 0 1 1 0 0 0 ROD_10581(putative electron transport protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2916(Putative electron transport protein yccM,quinol dehydrogenase membrane component,Uncharacterized Fe-S center protein,ferredoxin-type protein, NapH/MauN family,4Fe-4S binding domain) b0992(predicted 4Fe-4S membrane protein) Cluster3980 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2913(TorCAD operon transcriptional regulatory protein torR,DNA-binding transcriptional regulator TorR,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain) b0995(DNA-binding response regulator in two-component regulatory system with TorS) SL1344_3790(torCAD operon transcriptional regulatory protein) Cluster3981 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.281(RNA 3'-terminal phosphate cyclase,RNA 3'-terminal-phosphate cyclase,RNA 3'-terminal phosphate cyclase,RNA 3'-phosphate cyclase,RNA 3'-terminal phosphate cyclase) b4475(RNA 3'-terminal phosphate cyclase) SL1344_3485(rna 3'-terminal phosphate cyclase (ec 6.5.1.4) (rna-3'-phosphate cyclase) (rna cyclase)) Cluster3982 0 0 1 0 0 0 2 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2740(Bacterial Ig-like domain (group 2)) SL1344_0977(Tail Protein),SL1344_2561(predicted bacteriophage protein) Cluster3983 0 0 1 0 0 0 2 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2739(phage minor tail protein G,Bacteriophage lambda minor tail protein (GpG)) SL1344_0978(predicted bacteriophage protein),SL1344_2560(predicted bacteriophage protein) Cluster3984 0 0 1 0 0 0 2 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2738(phage tail assembly protein T,Minor tail protein T) SL1344_0979(predicted bacteriophage protein),SL1344_2559(predicted bacteriophage protein) Cluster3985 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.273(hypothetical protein,phosphate binding protein,PBP superfamily domain) pseudob3427(unknown) SL1344_3495(putative membrane protein) Cluster3986 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2706(Inhibitor of g-type lysozyme precursor,Bacterial pre-peptidase C-terminal domain) b1178(predicted protein) SL1344_2574(predicted bacteriophage protein) Cluster3987 0 0 1 1 0 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2702(Silent hemolysin SheA,hemolysin E,Haemolysin E (HlyE)) b1182(hemolysin E) t1477(haemolysin HlyE) Cluster3988 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2665(hypothetical protein) t0491(putative bacteriophage protein) SL1344_2342(predicted bacteriophage protein) Cluster3989 1 0 1 1 0 0 0 pseudoROD_50181(IS4 transposase (fragment)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2600(Insertion element 4 transposase N-terminal) b4278(IS4 transposase) Cluster3990 1 0 2 0 0 0 0 ROD_47411(hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2555(Domain of unknown function (DUF1737)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3084(Domain of unknown function (DUF303)) Cluster3991 0 0 2 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2514(Uncharacterized phage-encoded protein,phage regulatory protein, Rha family,Phage regulatory protein Rha (Phage_pRha)),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.21(Uncharacterized phage-encoded protein,phage regulatory protein, Rha family,Phage regulatory protein Rha (Phage_pRha)) SL1344_1965(predicted bacteriophage protein) Cluster3992 0 0 2 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2501(Predicted membrane protein (DUF2207)),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.32(Predicted membrane protein (DUF2207)) b1268(predicted inner membrane protein) Cluster3993 1 0 1 1 0 0 0 ROD_17001(putative sucrose phosphorylase (ec 2.4.1.7) (sucrose glucosyltransferase)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2457(Sucrose phosphorylase,sucrose phosphorylase,sucrose phosphorylase,Alpha amylase, catalytic domain) b1309(predicted glucosyltransferase) Cluster3994 1 0 1 1 0 0 0 ROD_16941(putative oxidoreductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2451(Uncharacterized oxidoreductase ycjS,putative oxidoreductase,Uncharacterized protein conserved in bacteria,Oxidoreductase family, NAD-binding Rossmann fold) b1315(predicted oxidoreductase, NADH-binding) Cluster3995 1 0 1 1 0 0 0 ROD_16901(outer membrane protein G precursor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2447(Outer membrane protein G precursor,Outer membrane protein G (OmpG)) b1319(outer membrane porin G) Cluster3996 1 0 1 1 0 0 0 ROD_16081(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2391(hypothetical protein,Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF465)) b1426(predicted protein) Cluster3997 1 0 1 1 0 0 0 ROD_15581(putative plasmid maintenance protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2353(Uncharacterized HTH-type transcriptional regulator YddM,Plasmid maintenance system antidote protein,addiction module antidote protein, HigA family,Helix-turn-helix) b1477(predicted DNA-binding transcriptional regulator) Cluster3998 1 0 1 1 0 0 0 ROD_15471(heme-regulated cyclic AMP phosphodiesterase (direct oxygen sensor protein)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2346(Oxygen sensor protein DosP,cyclic-di-GMP phosphodiesterase,MHYT domain (predicted integral membrane sensor domain),PAS domain S-box protein,EAL domain) b1489(oxygen sensor, c-di-GMP phosphodiesterase, heme-regulated; cold-and stationary phase-induced bioflim regulator) Cluster3999 1 0 1 1 0 0 0 ROD_13851(putative oxidoreductase subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2212(hypothetical protein) b1669(conserved protein) Cluster4000 1 0 1 1 0 0 0 ROD_13831(putative oxidoreductase Fe-S subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2210(DMSO reductase iron-sulfur subunit,tetrathionate reductase subunit B,cytochrome c nitrite reductase, Fe-S protein,4Fe-4S dicluster domain) b1671(predicted 4Fe-4S ferridoxin-type protein) Cluster4001 1 0 1 1 0 0 0 ROD_13821(putative oxidoreductase subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2209(hypothetical protein) b1672(predicted protein) Cluster4002 1 0 1 1 0 0 0 ROD_13811(putative aldehyde ferredoxin oxidoreductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2208(putative oxidoreductase,Aldehyde:ferredoxin oxidoreductase,Aldehyde ferredoxin oxidoreductase, domains 2 & 3) b1673(predicted oxidoreductase) Cluster4003 1 0 1 1 0 0 0 ROD_13801(putative oxidoreductase Fe-S subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2207(Uncharacterized ferredoxin-like protein ydhY,hypothetical protein,Uncharacterized Fe-S center protein,dimethylsulfoxide reductase, chain B,4Fe-4S binding domain) b1674(predicted 4Fe-4S ferridoxin-type protein) Cluster4004 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2190(Domain of unknown function (DUF1870)) b1689(conserved protein) SL1344_1297(Conserved hypothetical protein) Cluster4005 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2188(Inner membrane transport protein ydiN,putative transporter,MFS transporter, aromatic acid:H+ symporter (AAHS) family,Major Facilitator Superfamily) b1691(Inner membrane protein, predicted MFS superfamily transporter) pseudoSL1344_1294(Putative MFS-family transport protein (pseudogene)) Cluster4006 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2184(Crotonobetainyl-CoA dehydrogenase,putative acyl-CoA dehydrogenase,Rubredoxin,cyclohexanecarboxyl-CoA dehydrogenase,Acyl-CoA dehydrogenase, C-terminal domain) b1695(predicted acyl-CoA dehydrogenase) SL1344_1290(Putative acyl-CoA dehydrogenase) Cluster4007 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2183(Uncharacterized HTH-type transcriptional regulator ypdC,DNA-binding transcriptional regulator AraC,Adenosine deaminase,YSIRK-targeted surface antigen transcriptional regulator,Helix-turn-helix domain) b1696(predicted DNA-binding transcriptional regulator) SL1344_1289(putative HTH-type transcriptional regulator) Cluster4008 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2182(Electron transfer flavoprotein small subunit,hypothetical protein,Electron transfer flavoprotein, beta subunit,Electron transfer flavoprotein domain) b1697(predicted electron transfer flavoprotein subunit) SL1344_1288(putative electron transfer flavoprotein subunit) Cluster4009 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2181(Electron transfer flavoprotein large subunit,electron transfer flavoprotein subunit YdiR,Rubredoxin,Electron transfer flavoprotein FAD-binding domain) b1698(predicted electron transfer flavoprotein, FAD-binding subunit) SL1344_1287(putative electron transfer flavoprotein subunit) Cluster4010 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2180(Electron transfer flavoprotein-ubiquinone oxidoreductase,oxidoreductase,Bacterial lipocalin,geranylgeranyl reductase family,FAD dependent oxidoreductase) b1699(predicted oxidoreductase with FAD/NAD(P)-binding domain) SL1344_1286(putative electron transfer flavoprotein-quinone oxidoreductase) Cluster4011 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2179(ferredoxin-like protein FixX,Ferredoxin-like protein) b1700(predicted 3Fe-4S ferredoxin-type protein) SL1344_1285(ferredoxin-like protein) Cluster4012 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2178(Short-chain-fatty-acid--CoA ligase,short chain acyl-CoA synthetase,Uncharacterized protein conserved in bacteria,cyclohexanecarboxylate-CoA ligase,AMP-binding enzyme) b1701(short chain acyl-CoA synthetase, anaerobic) SL1344_1284(putative ligase/synthetase) Cluster4013 1 0 1 0 0 0 1 ROD_31591(sugar bisphosphate aldolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.212(D-tagatose-1,6-bisphosphate aldolase subunit KbaY,putative fructose-1,6-bisphosphate aldolase,Fructose/tagatose bisphosphate aldolase,fructose-1,6-bisphosphate aldolase, class II,Fructose-bisphosphate aldolase class-II) SL1344_3746(fructose-1,6-bisphosphate aldolase, class II) Cluster4014 1 0 1 1 0 0 0 pseudoROD_12851(putative transport protein (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2111(Inner membrane metabolite transport protein ydjE,putative 3-hydroxyphenylpropionic transporter MhpT,MFS transporter, aromatic acid:H+ symporter (AAHS) family,Sugar (and other) transporter) b1769(predicted transporter) Cluster4015 1 0 1 1 0 0 0 ROD_12841(DeoR-family transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2110(Glycerol-3-phosphate regulon repressor,DNA-binding transcriptional activator FucR,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,Bacterial regulatory proteins, deoR family) b1770(predicted DNA-binding transcriptional regulator) Cluster4016 1 0 1 1 0 0 0 ROD_12831(putative sugar reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2109(General stress protein 69,putative oxidoreductase,Predicted oxidoreductase,voltage-dependent potassium channel beta subunit,Aldo/keto reductase family) b1771(alpha-Keto reductase, NADH-dependent; can use methylglyoxal as substrate) Cluster4017 1 0 1 1 0 0 0 ROD_12801(putative zinc-binding dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2106(Sorbitol dehydrogenase,L-threonine 3-dehydrogenase,L-threonine 3-dehydrogenase,Alcohol dehydrogenase GroES-like domain) b1774(predicted oxidoreductase, Zn-dependent and NAD(P)-binding) Cluster4018 1 0 1 1 0 0 0 ROD_12781(putative zinc-binding dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2104(L-threonine 3-dehydrogenase,L-threonine 3-dehydrogenase,L-threonine 3-dehydrogenase,Alcohol dehydrogenase GroES-like domain) b1776(predicted oxidoreductase, Zn-dependent and NAD(P)-binding) Cluster4019 1 0 1 1 0 0 0 ROD_47571(cytochrome C-type protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2008(Cytochrome c-type protein TorY,trimethylamine N-oxide reductase cytochrome c-type subunit,trimethylamine-N-oxide reductase c-type cytochrome TorC,NapC/NirT cytochrome c family, N-terminal region) b1873(TMAO reductase III (TorYZ), cytochrome c-type subunit) Cluster4020 0 0 1 1 0 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1890(Transposase and inactivated derivatives,Transposase IS200 like) pseudob4578(unknown) t0101(putative IS element transposase) Cluster4021 0 0 3 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1851(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2022(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.610(hypothetical protein) Cluster4022 0 0 2 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1822(Bor protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2754(Bor protein) b0557(DLP12 prophage; predicted lipoprotein) Cluster4023 0 0 2 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1819(Protein of unknown function (DUF1327)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2553(Protein of unknown function (DUF1327)) b1555(Qin prophage; predicted protein) Cluster4024 0 0 2 0 0 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1804(Bacterial protein of unknown function (DUF977)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2567(Bacterial protein of unknown function (DUF977)) t1009(putative DNA-binding protein) Cluster4025 0 0 2 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1799(Protein of unknown function (DUF1391)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2574(Protein of unknown function (DUF1391)) b1571(Qin prophage; predicted protein) Cluster4026 1 0 1 0 0 0 1 pseudoROD_10341(putative phage integrase (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1791(site-specific tyrosine recombinase XerC,Site-specific recombinase XerD,tyrosine recombinase XerC,Phage integrase family) SL1344_1976(bacteriophage integrase) Cluster4027 1 0 1 1 0 0 0 ROD_09931(intimin-like protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1774(Bacterial Ig-like domain (group 1)) b1978(probable adhesin) Cluster4028 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1747(Uncharacterized protein conserved in bacteria,Protein of unknown function, DUF606) t3972(putative membrane protein) SL1344_3515(putative membrane protein) Cluster4029 0 0 3 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1738(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4138(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4875(hypothetical protein) Cluster4030 1 0 1 1 0 0 0 ROD_49671(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1710(Antitoxin YeeU,YagB/YeeU/YfjZ family) b2004(CP4-44 prophage; antitoxin of the YeeV-YeeU toxin-antitoxin system) Cluster4031 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1562(NAD-dependent dihydropyrimidine dehydrogenase subunit PreA,dihydropyrimidine dehydrogenase subunit B,Dihydroorotate dehydrogenase,dihydroorotate dehydrogenase family protein,Dihydroorotate dehydrogenase) b2147(Dihydropyrimidine dehydrogenase, NADH-dependent, subunit B) SL1344_2164(putative oxidoreductase) Cluster4032 1 0 1 1 0 0 0 ROD_22901(putative pyrimidine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1549(Pseudouridine kinase,putative kinase,Uncharacterized enzyme involved in pigment biosynthesis,ribokinase,pfkB family carbohydrate kinase) b2160(predicted kinase) Cluster4033 1 0 1 1 0 0 0 ROD_22921(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1545(Pseudouridine-5'-phosphate glycosidase,Uncharacterized enzyme involved in pigment biosynthesis,Indigoidine synthase A like protein) b2165(pseudouridine 5'-phosphate glycosidase) Cluster4034 1 0 1 1 0 0 0 ROD_22931(putative pyrimidine kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1544(Pseudouridine kinase,pseudouridine kinase,Uncharacterized enzyme involved in pigment biosynthesis,ribokinase,pfkB family carbohydrate kinase) b2166(pseudouridine kinase) Cluster4035 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1438(Mg-chelatase subunit ChlD,marine proteobacterial sortase target protein,Domain of unknown function (DUF3520)) b2270(conserved protein) SL1344_2284(lipoprotein) Cluster4036 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1379(Protein of unknown function (DUF2544)) b2332(predicted protein) SL1344_0202(putative exported protein) Cluster4037 1 0 1 1 0 0 0 ROD_28021(aminopeptidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1332(Aminopeptidase ypdE,exoaminopeptidase,glutamyl aminopeptidase,M42 glutamyl aminopeptidase) b2384(aminopeptidase) Cluster4038 0 0 1 1 0 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1233(hypothetical protein) b2506(conserved protein) t0350(putative exported protein) Cluster4039 0 0 1 0 0 1 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1228(intimin-like protein SinH) t0340(putative exported protein) SL1344_2478(putative exported protein) Cluster4040 0 0 1 1 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.104(Extracytoplasmic solute receptor protein yiaO,TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component,TRAP transporter solute receptor, DctP family,Bacterial extracellular solute-binding protein, family 7) b3579(L-dehydroascorbate transporter, periplasmic binding protein for TRAP (TRipartite ATP-independent Periplasmic) family transporter YiaMNO) SL1344_3638(putative periplasmic protein) Cluster4041 0 0 1 1 0 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1005(Inner membrane protein yqcE,D-galactonate transporter,Major Facilitator Superfamily) b2775(inner membrane protein, predicted transporter) t3934(putative membrane protein) Cluster4042 1 1 1 0 0 0 0 ROD_00331(putative LacI-family transcriptional regulator) ENC_45550(transcriptional regulator, LacI family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4434(HTH-type transcriptional repressor CytR,DNA-binding transcriptional repressor MalI,ABC-type sugar transport system, periplasmic component,catabolite control protein A,Periplasmic binding proteins and sugar binding domain of LacI family) Cluster4043 1 1 0 0 0 0 1 ROD_00271(hypothetical protein) ENC_45490(glucose-6-phosphate isomerase) SL1344_2741(putative glucose-6-phosphate isomerase) Cluster4044 0 1 1 1 0 0 0 ENC_45290(Protein of unknown function (DUF2502).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3990(Protein of unknown function (DUF2502)) b0005(predicted protein) Cluster4045 0 1 0 0 0 1 1 ENC_44380(AraC-type DNA-binding domain-containing proteins) t2501(AraC-family transcriptional regulator) SL1344_0358(AraC-family transcriptional regulator) Cluster4046 0 1 0 0 0 1 1 ENC_44320(Response regulator) t1255(putative two-component response regulator) SL1344_1321(putative two-component response regulator) Cluster4047 1 1 0 1 0 0 0 ROD_13561(Major Facilitator Superfamily transporter) ENC_43820(sugar (Glycoside-Pentoside-Hexuronide) transporter) b0270(CP4-6 prophage; predicted sugar transporter) Cluster4048 0 1 0 0 0 1 1 ENC_43780(arginine deiminase) t4501(arginine deiminase) SL1344_4397(arginine deiminase) Cluster4049 0 1 0 0 0 1 1 ENC_43770(carbamate kinase) t4500(carbamate kinase) SL1344_4396(carbamate kinase) Cluster4050 0 1 0 0 0 1 1 ENC_43750(Predicted membrane protein) t4498(putative membrane protein) SL1344_4394(putative membrane protein) Cluster4051 0 1 1 1 0 0 0 ENC_42520(Beta-lactamase class C and other penicillin binding proteins) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4305(Beta-lactamase precursor,beta-lactamase/D-alanine carboxypeptidase,Uncharacterized protein conserved in bacteria,Beta-lactamase) b4150(beta-lactamase/D-alanine carboxypeptidase) Cluster4052 0 1 1 1 0 0 0 ENC_42280(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4346(Inner membrane protein yjdF,hypothetical protein,Predicted membrane protein,Predicted membrane protein (DUF2238)) b4121(conserved inner membrane protein) Cluster4053 0 1 1 1 0 0 0 ENC_41350(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1682(dTDP-Rha:alpha-D-GlcNAc-pyrophosphate polyprenol, alpha-3-L-rhamnosyltransferase,mycofactocin system glycosyltransferase,Glycosyl transferase family 2) pseudob4571(unknown) Cluster4054 0 1 0 0 0 1 1 ENC_41320(Glycosyltransferase) t0787(putative glycosyl transferase) SL1344_2063(putative glycosyltransferase) Cluster4055 0 1 0 0 0 1 1 ENC_36720(hypothetical protein) t0255(conserved hypothetical protein) SL1344_2619(conserved hypothetical protein) Cluster4056 0 1 1 1 0 0 0 ENC_36600(ABC-type Fe3+-siderophore transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4153(Iron(III) dicitrate transport system permease protein fecC,iron-dicitrate transporter permease subunit,ABC-type Fe3+-siderophore transport system, permease component,proposed F420-0 ABC transporter, permease protein,FecCD transport family) b4289(KpLE2 phage-like element; iron-dicitrate transporter subunit) Cluster4057 0 1 1 1 0 0 0 ENC_36590(ABC-type Fe3+-siderophore transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4154(Iron(III) dicitrate transport system permease protein fecD,iron-dicitrate transporter subunit FecD,ABC-type Fe3+-siderophore transport system, permease component,proposed F420-0 ABC transporter, permease protein,FecCD transport family) b4288(KpLE2 phage-like element; iron-dicitrate transporter subunit) Cluster4058 1 1 1 0 0 0 0 pseudoROD_41061(F pilin acetylation protein TraX (fragment)) ENC_35280(TraX protein.) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.59(conjugal transfer pilus acetylation protein TraX,type-F conjugative transfer system pilin acetylase TraX,TraX protein) Cluster4059 0 1 0 0 0 1 1 ENC_35130(diguanylate cyclase/phosphodiesterase) t3302(putative exported protein) SL1344_3361(putative membrane protein) Cluster4060 0 1 1 1 0 0 0 ENC_33790(galactosamine 6-phosphate isomerase AgaS) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.556(Putative tagatose-6-phosphate ketose/aldose isomerase,glucosamine--fructose-6-phosphate aminotransferase,Predicted phosphosugar isomerases,putative sugar isomerase, AgaS family,SIS domain) b3136(tagatose-6-phosphate ketose/aldose isomerase) Cluster4061 0 1 1 1 0 0 0 ENC_33760(PTS system N-acetylgalactosamine-specific EIIB component, Man family (TC 4.A.6.1.4)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.561(Fructose-specific phosphotransferase enzyme IIB component,PTS system N-acetylgalactosamine-specific transporter subunit IIB,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,PTS system, mannose/fructose/sorbose family, IIB component,PTS system sorbose subfamily IIB component) b3133(N-acetylgalactosamine-specific enzyme IIB component of PTS) Cluster4062 0 1 1 1 0 0 0 ENC_33750(tagatose-bisphosphate aldolase noncatalytic subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.562(D-tagatose-1,6-bisphosphate aldolase subunit kbaZ,tagatose 6-phosphate aldolase subunit KbaZ,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit,Tagatose 6 phosphate kinase) b3132(tagatose 6-phosphate aldolase 1, kbaZ subunit) Cluster4063 0 1 1 1 0 0 0 ENC_33740(Transcriptional regulators of sugar metabolism) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.563(HTH-type transcriptional repressor glcR,DNA-binding transcriptional regulator AgaR,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,Bacterial regulatory proteins, deoR family) b3131(DNA-binding transcriptional repressor of the aga regulon) Cluster4064 0 1 0 0 0 1 1 ENC_33290(hypothetical protein) t0025(fimbrial subunit) SL1344_0024(fimbrial subunit) Cluster4065 0 1 0 0 0 1 1 ENC_33270(P pilus assembly protein, chaperone PapD) t0023(fimbrial chaperone) SL1344_0022(fimbrial chaperone) Cluster4066 0 1 1 1 0 0 0 ENC_32870(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.649(hypothetical protein) b0716(predicted fimbrial-like adhesin protein) Cluster4067 1 1 0 0 0 0 1 ROD_35501(putative exported protein) ENC_32410(hypothetical protein) SL1344_3128(exported protein) Cluster4068 1 1 0 0 0 0 1 pseudoROD_35471(methyl-accepting chemotaxis protein (fragment)) ENC_32380(Methyl-accepting chemotaxis protein) SL1344_3126(methyl-accepting chemotaxis protein) Cluster4069 0 1 0 0 0 1 1 ENC_31810(Sugar phosphate permease) t3687(putative membrane transport protein) SL1344_3799(putative membrane transport protein) Cluster4070 0 1 1 1 0 0 0 ENC_31690(Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.818(Mannitol-specific cryptic phosphotransferase enzyme IIA component,putative PTS system mannitol-specific transporter subunit IIA,PTS system, fructose subfamily, IIA component,Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2) b2934(predicted mannitol-specific enzyme IIA component of PTS) Cluster4071 0 1 1 1 0 0 0 ENC_31630(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.822(hypothetical protein,putative DNA-binding transcriptional regulator,Mannitol repressor) b2929(predicted DNA-binding transcriptional regulator) Cluster4072 0 1 1 1 0 0 0 ENC_29150(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3648(HTH-type transcriptional activator AllS,DNA-binding transcriptional activator AllS,aminoethylphosphonate catabolism associated LysR family transcriptional regulator,LysR substrate binding domain) b0316(predicted DNA-bindng transcriptional regulator) Cluster4073 0 1 1 1 0 0 0 ENC_29140(FOG: Ankyrin repeat) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3646(Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases,transient-receptor-potential calcium channel protein,Ankyrin repeats (3 copies)) b0318(ankyrin repeat protein) Cluster4074 0 1 1 1 0 0 0 ENC_29130(Succinyl-CoA synthetase, alpha subunit) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3644(hypothetical protein,membrane protein FdrA,Succinyl-CoA synthetase, alpha subunit,succinate-CoA ligase, alpha subunit,CoA-ligase) b0320(predicted acyl-CoA synthetase with NAD(P)-binding domain and succinyl-CoA synthetase domain) Cluster4075 0 1 1 1 0 0 0 ENC_29120(Protein of unknown function (DUF1116).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3643(Protein of unknown function (DUF1116)) b0321(conserved protein) Cluster4076 0 1 1 1 0 0 0 ENC_29100(carbamate kinase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3642(Carbamate kinase 1,putative carbamate kinase,carbamate kinase,Amino acid kinase family) b0323(carbamate kinase-like protein) Cluster4077 0 1 1 1 0 0 0 ENC_29090(Cytosine deaminase and related metal-dependent hydrolases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3641(N-isopropylammelide isopropyl amidohydrolase,putative deaminase,Cytosine deaminase and related metal-dependent hydrolases,Amidohydrolase family) b0324(predicted deaminase with metallo-dependent hydrolase domain) Cluster4078 0 1 1 1 0 0 0 ENC_29040(addiction module antidote protein, HigA family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3495(Uncharacterized HTH-type transcriptional regulator ybaQ,Plasmid maintenance system antidote protein,addiction module antidote protein, HigA family,Helix-turn-helix) b0483(predicted DNA-binding transcriptional regulator) Cluster4079 1 1 1 0 0 0 0 ROD_03121(lateral flagellar L-ring protein) ENC_28420(Flagellar basal body L-ring protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3724(Basal body L-ring protein,flagellar basal body L-ring protein,Flagellar L-ring protein) Cluster4080 1 1 1 0 0 0 0 ROD_03131(lateral flagellar P-ring protein) ENC_28410(Flagellar basal-body P-ring protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3723(Basal body P-ring protein,flagellar basal body P-ring protein,Flagellar basal-body P-ring protein,Flagellar P-ring protein) Cluster4081 0 1 1 1 0 0 0 ENC_27990(Protein of unknown function (DUF2799).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1139(lipoprotein,Protein of unknown function (DUF2799)) b2602(lipoprotein) Cluster4082 0 1 1 1 0 0 0 ENC_27530(Protein of unknown function (DUF1019).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2768(Protein of unknown function (DUF1019)) b1358(Rac prophage; predicted protein) Cluster4083 0 1 0 0 0 1 1 ENC_27150(hypothetical protein) t3912(phage-like lysozyme) SL1344_3570(bacteriophage-like lysozyme) Cluster4084 0 1 0 0 0 1 1 ENC_24170(Predicted acyltransferases) t0466(putative lipopolysaccharide modification acyltransferase) SL1344_2208(putative lipopolysaccharide modification acyltransferase) Cluster4085 1 1 1 0 0 0 0 ROD_04491(putative exported protein) ENC_23590(Predicted membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2653(Predicted membrane protein,Predicted membrane protein (DUF2339)) Cluster4086 1 1 1 0 0 0 0 ROD_04501(putative exported protein) ENC_23580(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2651(hypothetical protein) Cluster4087 0 1 1 1 0 0 0 ENC_23350(6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.551(Glucosamine-6-phosphate deaminase 1,galactosamine-6-phosphate isomerase,glucosamine-6-phosphate deaminase,Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase) b3141(galactosamine-6-phosphate isomerase) Cluster4088 0 1 1 0 0 0 1 ENC_22200(PTS system, glucose-like IIB component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4689(EIICBA-Glc,PTS system glucose-specific transporter subunits IIBC,PTS system, glucose-specific IIBC component,Phosphotransferase system, EIIC) SL1344_2742(PTS system, glucose-specific IIbc component) Cluster4089 0 1 1 1 0 0 0 ENC_20070(PTS system mannosylglycerate-specific IIA component, Fru family (TC 4.A.2.1.3)/PTS system mannosylglycerate-specific IIB component, Fru family (TC 4.A.2.1.3)/PTS system mannosylglycerate-specific IIC component, Fru family (TC 4.A.2.1.3)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3269(Putative PTS system EIIABC component,PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC,PTS system, Fru family, IIC component,Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2) b0731(fused 2-O-a-mannosyl-D-glycerate specific PTS enzymes: IIA component/IIB component/IIC component) Cluster4090 0 1 1 1 0 0 0 ENC_20060(Alpha-mannosidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3268(Mannosylglycerate hydrolase,alpha-mannosidase,Alpha-mannosidase,Glycosyl hydrolases family 38 N-terminal domain) b0732(alpha-mannosidase) Cluster4091 0 1 1 1 0 0 0 ENC_19300(Protein of unknown function (DUF1471).) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3192(Multiple stress resistance protein BhsA precursor,hypothetical protein,Protein of unknown function (DUF1471)) b0806(colanic acid mucoidy stimulation protein) Cluster4092 1 1 0 0 0 0 1 pseudoROD_01891(putative polysaccharide degrading enzyme (pseudogene)) ENC_18200(Uncharacterized protein contain chitin-binding domain type 3) SL1344_0234(putative secreted chitinase) Cluster4093 0 1 0 0 0 1 1 ENC_17480(Putative excisionase (DUF1233).) t1928(excisionase) SL1344_0943(bacteriophage excisionase) Cluster4094 0 1 1 1 0 0 0 ENC_14190(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2158(hypothetical protein) b4535(predicted protein) Cluster4095 1 1 0 0 0 0 1 ROD_18171(putative fimbrial chaperone protein) ENC_13850(P pilus assembly protein, chaperone PapD) SL1344_0177(fimbrial usher protein) Cluster4096 0 1 0 0 0 1 1 ENC_10750(Protein of unknown function (DUF1311).) t2363(probable secreted protein) SL1344_0490(probable secreted protein) Cluster4097 1 1 0 1 0 0 0 ROD_40491(putative membrane protein) ENC_09720(hypothetical protein) b3677(inner membrane protein) Cluster4098 1 1 0 0 0 0 1 pseudoROD_27701(IcmF family T6SS protein Cts1I) ENC_07210(type VI secretion protein IcmF) SL1344_0280(probable IcmF-related integral membrane ATP-binding protein, virulence associated protein) Cluster4099 0 1 0 0 0 1 1 ENC_06560(Uncharacterized protein conserved in bacteria) t2675(virulence protein) SL1344_2764(virulence protein) Cluster4100 0 1 1 1 0 0 0 ENC_05430(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4356(hypothetical protein) b4110(mutational suppressor of yhjH motility mutation, function unknown) Cluster4101 0 1 1 1 0 0 0 ENC_05420(Dynamin family.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4357(hypothetical protein,Predicted GTPase,small GTP-binding protein domain,Dynamin family) b4109(mutational suppressor of yhjH motility mutation, function unknown; related to Dynamin GTPase) Cluster4102 0 1 1 1 0 0 0 ENC_05250(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4374(hypothetical protein) b4487(conserved protein) Cluster4103 0 1 1 1 0 0 0 ENC_03130(Antitoxin of toxin-antitoxin stability system) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1695(Antitoxin YefM,antitoxin YefM,prevent-host-death family protein,Phd_YefM) b2017(antitoxin of the YoeB-YefM toxin-antitoxin system) Cluster4104 0 1 0 0 0 1 1 ENC_02880(Ash protein family.) t4526(phage immunity repressor protein) SL1344_2719(predicted bacteriophage protein) Cluster4105 0 2 0 0 0 1 0 ENC_02860(hypothetical protein),ENC_43940(hypothetical protein) t4524(putative phage capsid protein) Cluster4106 0 1 0 0 0 1 1 ENC_02430(Glycosyltransferases involved in cell wall biogenesis) t0786(putative glycosyl transferase) SL1344_2064(putative glycosyltransferase) Cluster4107 1 1 0 0 0 0 1 ROD_11791(putative exported protein) ENC_00500(hypothetical protein) SL1344_4498(putative fimbrial protein) Cluster4108 0 0 1 0 1 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1756(ParB-like nuclease domain) BN373_p02161(conserved hypothetical protein) t4278(conserved hypothetical protein) Cluster4109 0 0 0 0 1 1 1 BN373_p02141(IroC) t2669(putative ABC transporter protein) SL1344_2759(putative ABC transporter protein) Cluster4110 1 0 1 0 1 0 0 pseudoROD_47801(IS21 family transposase B (fragment)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1737(transposase/IS protein,DNA replication protein,IstB-like ATP binding protein) BN373_p01841(transposase/IS protein) Cluster4111 0 1 1 0 1 0 0 ENC_35700(ParB-like partition proteins) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.124(Plasmid partition protein B,plasmid-partitioning protein,ParB/RepB/Spo0J family partition protein,ParB-like nuclease domain) BN373_p01731(plasmid-partitioning protein) Cluster4112 0 0 0 0 1 1 1 BN373_p00931(conserved hypothetical protein) t2946(conserved hypothetical protein) SL1344_3013(conserved hypothetical protein) Cluster4113 0 1 1 0 1 0 0 ENC_35660(Site-specific recombinase XerD) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.127(Tyrosine recombinase XerD,site-specific tyrosine recombinase XerD,Site-specific recombinase XerD,tyrosine recombinase XerD,Phage integrase family) BN373_p00511(phage integrase family protein) Cluster4114 0 0 0 0 1 1 1 BN373_p00401(lysozyme inhibitor) t1123(putative secreted protein) SL1344_1185(putative secreted protein) Cluster4115 0 1 1 0 1 0 0 ENC_41870(Arabinose efflux permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.765(Major Facilitator Superfamily) BN373_p00341(ShiF) Cluster4116 0 1 1 0 1 0 0 ENC_41860(Siderophore synthetase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.764(Aerobactin synthase IucA,IucA / IucC family) BN373_p00331(conserved hypothetical protein) Cluster4117 0 1 1 0 1 0 0 ENC_41850(Siderophore biosynthesis protein domain.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.763(N(6)-hydroxylysine O-acetyltransferase,Siderophore biosynthesis protein domain) BN373_p00321(IucB) Cluster4118 0 0 2 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.761(L-lysine 6-monooxygenase,Lysine/ornithine N-monooxygenase),Escherichia_coli_UPEC_ST131_v0.1_5_5104002-5133359.32(L-lysine 6-monooxygenase,Lysine/ornithine N-monooxygenase) BN373_p00301(IucD) Cluster4119 0 0 0 0 1 1 1 BN373_p00061(conserved hypothetical protein) t1016(putative membrane protein) SL1344_1793(inner membrane protein (PagO)) Cluster4120 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4557(Uncharacterized inner membrane transporter yiJE,putative DMT superfamily transporter inner membrane protein,Predicted permease, DMT superfamily,carboxylate/amino acid/amine transporter,EamA-like transporter family) b3943(inner membrane protein, predicted permease) BN373_48731(conserved hypothetical protein) Cluster4121 1 1 0 0 1 0 0 ROD_38621(putative exported protein) ENC_00460(Protein of unknown function (DUF1471).) BN373_48241(conserved hypothetical protein) Cluster4122 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4799(Cryptic outer membrane porin BglH precursor,maltoporin,Maltoporin (phage lambda and maltose receptor),LamB porin) b3720(carbohydrate-specific outer membrane porin, cryptic) BN373_47641(putative outer membrane porin) Cluster4123 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4800(hypothetical protein,enterobactin/ferric enterobactin esterase,Predicted hydrolase of the alpha/beta superfamily,Putative esterase) b3719(predicted xylanase) BN373_47631(putative esterase) Cluster4124 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4801(Glucosamine-6-phosphate deaminase,putative 6-phosphogluconolactonase,glucosamine-6-phosphate deaminase,Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase) b3718(predicted 6-phosphogluconolactonase) BN373_47621(putative glucosamine-6-phosphate isomerase) Cluster4125 0 0 0 1 1 0 1 b4557(conserved protein, UPF0161 family) BN373_47521(conserved hypothetical protein) SL1344_3808(conserved hypothetical protein) Cluster4126 1 0 0 1 1 0 0 ROD_40421(GntR-family transcriptional regulator) b3684(predicted DNA-binding transcriptional regulator) BN373_47311(transcriptional regulator, GntR family) Cluster4127 0 0 1 0 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4854(Uncharacterized protein conserved in bacteria,Protein of unknown function (DUF1044)) BN373_47101(conserved hypothetical protein) SL1344_3743(conserved hypothetical protein) Cluster4128 0 0 0 0 1 1 1 BN373_47081(phosphonoacetaldehyde hydrolase) t2431(phosphonoacetaldehyde phosphonohydrolase) SL1344_0426(phosphonoacetaldehyde phosphonohydrolase) Cluster4129 0 0 0 0 1 1 1 BN373_47071(2-aminoethylphosphonate--pyruvate transaminase) t2432(2-aminoethylphosphonate:pyruvate aminotransferase) SL1344_0425(2-aminoethylphosphonate:pyruvate aminotransferase) Cluster4130 0 0 0 0 1 1 1 BN373_47041(2-aminoethylphosphonate transporter ATP-binding component) t2435(probable ATP-binding component of 2-aminoethylphosphonate transporter) SL1344_0422(probable ATP-binding component of 2-aminoethylphosphonate transporter) Cluster4131 0 0 0 0 1 1 1 BN373_47031(2-aminoethylphosphonate transport system permease PhnU) t2436(probable membrane component of 2-aminoethylphosphonate transporter) SL1344_0421(probable membrane component of 2-aminoethylphosphonate transporter) Cluster4132 0 0 0 0 1 1 1 BN373_47021(2-aminoethylphosphonate transport system memrane component) t2437(probable membrane component of 2-aminoethylphosphonate transporter) SL1344_0420(probable membrane component of 2-aminoethylphosphonate transporter) Cluster4133 1 1 0 0 1 0 0 ROD_41151(putative PTS system protein, component IIA) ENC_03480(Phosphotransferase system cellobiose-specific component IIA) BN373_46991(PTS system, lactose/cellobiose specific IIA subunit) Cluster4134 1 1 0 0 1 0 0 ROD_41181(PTS system, cellobiose-specific IIb component) ENC_03450(Phosphotransferase system cellobiose-specific component IIB) BN373_46971(PTS system, lactose/cellobiose family IIB subunit) Cluster4135 1 1 0 0 1 0 0 ROD_41191(putative LacI-family transcriptional regulator) ENC_03440(transcriptional regulator, LacI family) BN373_46961(transcriptional regulator, LacI family) Cluster4136 0 1 1 0 1 0 0 ENC_03420(drug resistance transporter, Bcr/CflA subfamily) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2470(Sulfonamide resistance protein,bicyclomycin/multidrug efflux system,Arabinose efflux permease,drug resistance transporter, Bcr/CflA subfamily,Major Facilitator Superfamily) BN373_46841(drug resistance transporter, Bcr/CflA subfamily) Cluster4137 0 1 1 0 1 0 0 ENC_03410(efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2471(Probable efflux pump outer membrane protein ttgC precursor,copper/silver efflux system outer membrane protein CusC,efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family,Outer membrane efflux protein) BN373_46831(multidrug efflux transporter EefC) Cluster4138 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4857(Lipoprotein 28 precursor,cytoplasmic membrane lipoprotein-28,lipoprotein, YaeC family,NLPA lipoprotein) b3661(cytoplasmic membrane lipoprotein-28) BN373_46721(lipoprotein NlpA) Cluster4139 0 0 0 0 1 1 1 BN373_46661(conserved hypothetical protein) t0021(conserved hypothetical protein) SL1344_0020(conserved hypothetical protein) Cluster4140 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.122(Inner membrane protein yiaA,hypothetical protein,Predicted membrane protein,yiaA/B two helix domain) b3562(inner membrane protein, YiaAB family) BN373_45691(putative membrane protein) Cluster4141 0 1 0 1 1 0 0 ENC_35920(Transposase and inactivated derivatives) b3557(IS150 transposase A) BN373_45641(putative IS3 family transposase orfA) Cluster4142 1 1 0 0 1 0 0 ROD_43221(LysR-family transcriptional regulator) ENC_26960(Transcriptional regulator) BN373_44841(transcriptional regulator, LysR family) Cluster4143 1 1 0 0 1 0 0 ROD_43231(phenolic acid decarboxylase) ENC_26950(Phenolic acid decarboxylase) BN373_44831(phenolic acid decarboxylase) Cluster4144 1 0 0 1 1 0 0 ROD_43631(4-aminobutyrate aminotransferase) b1302(GABA aminotransferase, PLP-dependent) BN373_44601(putative 4-aminobutyrate transaminase) Cluster4145 0 0 0 0 1 1 1 BN373_42881(YcfR family protein) t3277(conserved hypothetical protein) SL1344_3334(conserved hypothetical protein) Cluster4146 0 0 0 0 1 1 1 BN373_41981(periplasmic protein) t2543(probable secreted protein) SL1344_0303(probable secreted protein (SPI-6 associated)) Cluster4147 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.619(tRNA-binding protein ygjH,tRNA-binding protein,EMAP domain,methionine--tRNA ligase, beta subunit,Putative tRNA binding domain) b3074(conserved tRNA binding protein) BN373_41561(tRNA-binding protein) Cluster4148 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2680(PTS-dependent dihydroxyacetone kinase, phosphotransferase subunit dhaM,dihydroxyacetone kinase subunit M,Uncharacterized protein conserved in bacteria,dihydroxyacetone kinase, phosphotransfer subunit,PTS system fructose IIA component) b1198(fused predicted dihydroxyacetone-specific PTS enzymes: HPr component/EI component) BN373_41511(PTS-dependent dihydroxyacetone kinase, phosphotransferase subunit DhaM) Cluster4149 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2679(PTS-dependent dihydroxyacetone kinase, ADP-binding subunit dhaL,dihydroxyacetone kinase subunit DhaL,dihydroxyacetone kinase, L subunit,DAK2 domain) b1199(dihydroxyacetone kinase, C-terminal domain) BN373_41501(dihydroxyacetone kinase, ADP-binding subunit) Cluster4150 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2677(Quorum-sensing regulator protein F,DNA-binding transcriptional regulator DhaR,Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,PEP-CTERM-box response regulator transcription factor,Sigma-54 interaction domain) b1201(DNA-binding transcription activator of the dhaKLM operon) BN373_41471(PTS-dependent dihydroxyacetone kinase operon regulatory protein) Cluster4151 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.736(hypothetical protein,Domain of unknown function (DUF336)) b2977(conserved protein) BN373_41431(conserved hypothetical protein) Cluster4152 1 1 0 0 1 0 0 ROD_36151(urease accessory protein ureg) ENC_33080(urease accessory protein UreG) BN373_41241(urease accessory protein UreG) Cluster4153 1 1 0 0 1 0 0 ROD_36141(urease accessory protein UreF) ENC_33070(Urease accessory protein UreF) BN373_41231(urease accessory protein UreF) Cluster4154 1 1 0 0 1 0 0 ROD_36131(urease accessory protein UreE) ENC_33050(Urease accessory protein UreE) BN373_41221(urease accessory protein UreE) Cluster4155 1 1 0 0 1 0 0 ROD_36111(urease subunit beta) ENC_33030(urease, beta subunit) BN373_41201(urease, beta subunit) Cluster4156 1 1 0 0 1 0 0 ROD_36101(urease subunit gamma) ENC_33020(urease, gamma subunit) BN373_41191(urease, gamma subunit) Cluster4157 1 1 0 0 1 0 0 ROD_36091(urease accessory protein UreD) ENC_33010(Urease accessory protein UreH) BN373_41181(urease accessory protein UreD) Cluster4158 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.706(Carboxymethylenebutenolidase,Dienelactone hydrolase family) pseudob4658(unknown) BN373_40761(dienelactone hydrolase family protein) Cluster4159 1 1 0 0 1 0 0 ROD_35711(putative aminotransferase) ENC_29050(Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs) BN373_40711(aminotransferase, classes I and II) Cluster4160 0 1 0 1 1 0 0 ENC_31420(Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)) b2902(predicted NAD(P)-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain) BN373_40021(NAD dependent epimerase/dehydratase family) Cluster4161 0 0 0 0 1 1 1 BN373_40011(suppressor for copper-sensitivity D) t1804(secreted copper-sensitivity suppressor D) SL1344_1055(secreted protein, suppressor for copper-sensitivity D) Cluster4162 0 0 0 0 1 1 1 BN373_40001(suppressor for copper-sensitivity C) t1805(secreted copper-sensitivity suppressor C) SL1344_1054(secreted protein, suppressor for copper-sensitivity C precursor) Cluster4163 0 0 0 0 1 1 1 BN373_39991(suppressor for copper-sensitivity B) t1806(membrane protein, suppressor for copper-sensitivity B precursor) SL1344_1053(membrane protein, suppressor for copper-sensitivity B precursor) Cluster4164 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1346(Sensor protein evgS precursor,hybrid sensory histidine kinase in two-component regulatory system with EvgA,Response regulator containing a CheY-like receiver domain and a GGDEF domain,TMAO reductase sytem sensor TorS,Bacterial extracellular solute-binding proteins, family 3) b2370(hybrid sensory histidine kinase in two-component regulatory system with EvgA) BN373_39751(hybrid sensory histidine kinase in two-component regulatory system with EvgA) Cluster4165 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.183(10K-S protein,acid-resistance protein,hns-dependent expression protein A (HdeA)) b3510(stress response protein acid-resistance protein) BN373_39701(acid-resistance protein) Cluster4166 0 0 0 0 1 1 1 BN373_39681(putative ABC transport ATP-binding subunit) t1137(putative ABC transport ATP-binding subunit) SL1344_1195(putative ABC transport ATP-binding subunit) Cluster4167 0 0 0 0 1 1 1 BN373_39671(nickel/di-oligopepetide ABC transporter ATP binding protein) t1136(putative ABC transport ATP-binding protein) SL1344_1194(putative ABC transport ATP-binding protein) Cluster4168 0 0 0 0 1 1 1 BN373_39661(Adipeptide/di-oligopeptide/nickel ABC transporter permease subunit) t1134(putative inner membrane transport protein) SL1344_1193(putative inner membrane transport protein) Cluster4169 0 0 0 0 1 1 1 BN373_39651(membrane protein) t1135(putative inner membrane transport protein) SL1344_1192(putative inner membrane transport protein) Cluster4170 0 0 0 0 1 1 1 BN373_39641(putative substrate-binding transport protein) t1133(putative substrate-binding transport protein) SL1344_1191(putative substrate-binding transport protein) Cluster4171 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1348(Inner membrane protein yibH,multidrug efflux system protein EmrA,efflux pump membrane protein,HlyD family secretion protein) b2368(EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component) BN373_39511(multidrug resistance protein) Cluster4172 0 1 0 1 1 0 0 ENC_18630(transcriptional regulator, ArsR family) b3501(DNA-binding transcriptional repressor) BN373_39371(arsenical resistance operon repressor) Cluster4173 0 1 0 1 1 0 0 ENC_18640(arsenite efflux membrane protein ArsB (TC 3.A.4.1.1; TC 2.A.45.1.1)) b3502(arsenite/antimonite transporter) BN373_39361(arsenical pump membrane protein) Cluster4174 1 1 0 0 1 0 0 ROD_03881(putative peptide transport protein) ENC_37530(amino acid/peptide transporter (Peptide:H+ symporter), bacterial) BN373_39341(amino acid/peptide transporter) Cluster4175 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4386(Multidrug resistance outer membrane protein MdtP precursor,putative outer membrane efflux protein MdtP,efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family,Outer membrane efflux protein) b4080(outer membrane factor of efflux pump) BN373_39321(multidrug resistance outer membrane protein MdtP) Cluster4176 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4385(multidrug efflux system protein MdtO,Predicted membrane protein,integral membrane protein, YccS/YhfK family,Fusaric acid resistance protein family) b4081(membrane translocase (MDR) of MdtNOP efflux pump, PET family) BN373_39311(multidrug resistance protein MdtO) Cluster4177 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4384(Inner membrane protein yiaV precursor,multidrug resistance protein MdtN,efflux pump membrane protein,HlyD family secretion protein) b4082(membrane fusion protein of efflux pump) BN373_39301(multidrug resistance protein MdtN) Cluster4178 1 1 0 0 1 0 0 ROD_34891(putative outer membrane protein) ENC_05460(ABC-type uncharacterized transport system, permease component) BN373_39151(putative membrane protein) Cluster4179 0 1 1 0 1 0 0 ENC_19370(P pilus assembly protein, pilin FimA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3830(S-fimbrillin,fimbrial protein StiA,P pilus assembly protein, pilin FimA,Fimbrial protein) BN373_39081(fimbrial protein) Cluster4180 1 1 0 0 1 0 0 ROD_28931(oligogalacturonate lyase) ENC_30910(Periplasmic component of the Tol biopolymer transport system) BN373_38971(oligogalacturonate lyase) Cluster4181 1 1 0 0 1 0 0 ROD_28891(putative ABC transporter periplasmic binding protein) ENC_30870(oligogalacturonide-binding protein) BN373_38901(oligogalacturonide ABC transporter, periplasmic pectic oligomer-binding protein) Cluster4182 1 1 0 0 1 0 0 ROD_28881(putative ABC transporter protein) ENC_30860(ABC-type sugar transport systems, ATPase components) BN373_38891(oligogalacturonide ABC transporter, ATP-binding protein) Cluster4183 1 1 0 0 1 0 0 ROD_28871(putative ABC transporter membrane protein) ENC_30840(oligogalacturonide ABC transporter membrane protein) BN373_38881(oligogalacturonide ABC transporter, permease protein TogN) Cluster4184 1 1 0 0 1 0 0 ROD_28861(putative ABC transporter membrane protein) ENC_30830(oligogalacturonide ABC transporter membrane protein) BN373_38871(oligogalacturonide ABC transporter, permease protein TogM) Cluster4185 1 1 0 0 1 0 0 ROD_28851(putative pectin degradation protein) ENC_30810(Cupin domain.) BN373_38861(pectin degradation protein KdgF) Cluster4186 1 0 0 0 1 0 1 ROD_21351(propanediol utilization: polyhedral bodies) BN373_38441(propanediol utilization protein PduN) SL1344_2025(propanediol utilization protein) Cluster4187 1 0 0 0 1 0 1 ROD_21181(cobalt-precorrin-8X methylmutase (Cobalt-precorrin isomerase) (HBA synthase)) BN373_38281(precorrin-8X methylmutase) SL1344_2009(precorrin-8X methylmutase) Cluster4188 1 0 0 0 1 0 1 ROD_21111(cobalt-precorrin-6A reductase) BN373_38211(precorrin-6x reductase) SL1344_2002(cobalt-precorrin-6a reductase (ec 1.3.1.-)) Cluster4189 1 0 0 0 1 0 1 ROD_21101(sirohydrochlorin cobaltochelatase) BN373_38201(sirohydrochlorin cobaltochelatase) SL1344_2001(sirohydrochlorin cobaltochelatase (ec 4.99.1.3)) Cluster4190 1 0 0 0 1 0 1 ROD_21081(cobalamin biosynthesis protein CbiM) BN373_38181(cobalamin biosynthesis protein CbiM) SL1344_1999(cobalamin biosynthesis protein) Cluster4191 1 0 0 1 1 0 0 ROD_05801(putative host cell-killing modulation protein) b4415(toxic polypeptide, small) BN373_37391(Hok/Gef family protein) Cluster4192 0 0 1 0 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1360(DNA primase TraC,Superfamily II helicase and inactivated derivatives,Domain of unknown function (DUF927)) BN373_37321(predicted integrase) SL1344_2729(putative inner membrane protein) Cluster4193 0 1 1 0 1 0 0 ENC_14040(ABC-type hemin transport system, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.186(Hemin import ATP-binding protein HmuV,hemin importer ATP-binding subunit,Putative heme degradation protein,proposed F420-0 ABC transporter, ATP-binding protein,ABC transporter) BN373_37241(hemin ABC transporter, ATP-binding protein) Cluster4194 0 1 1 0 1 0 0 ENC_14030(ABC-type Fe3+-siderophore transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.187(Probable ABC transporter permease protein HI_1471,vtamin B12-transporter permease,Putative heme degradation protein,proposed F420-0 ABC transporter, permease protein,FecCD transport family) BN373_37231(hemin ABC transporter, permease protein) Cluster4195 0 1 1 0 1 0 0 ENC_14020(ABC-type hemin transport system, periplasmic component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.191(Hemin-binding periplasmic protein hmuT precursor,vitamin B12-transporter protein BtuF,ABC-type hemin transport system, periplasmic component,putative ABC transporter PGF-CTERM-modified substrate-binding protein,Periplasmic binding protein) BN373_37221(hemin ABC transporter, periplasmic hemin-binding protein) Cluster4196 0 1 1 0 1 0 0 ENC_14010(Putative heme degradation protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.193(Hemin transport protein hemS,Putative heme degradation protein,putative heme utilization carrier protein HutX,Haemin-degrading HenS.ChuX domain) BN373_37211(hemin transport protein HmuS) Cluster4197 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1344(putative transporter YfdV,auxin efflux carrier,Membrane transport protein) b2372(predicted transporter) BN373_37171(transporter, auxin efflux carrier family) Cluster4198 1 1 0 0 1 0 0 ROD_30971(putative exported protein) ENC_29860(HSP20-like domain of unknown function (DUF1813).) BN373_36861(conserved hypothetical protein) Cluster4199 0 1 1 0 1 0 0 ENC_29360(transcriptional regulator, AraC family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2429(HTH-type transcriptional repressor of iron proteins A,DNA-binding transcriptional regulator AraC,Adenosine deaminase,YSIRK-targeted surface antigen transcriptional regulator,Helix-turn-helix domain) BN373_36551(putative transcriptional regulator, AraC family) Cluster4200 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1097(putative L-valine exporter,Branched-chain amino acid transport protein (AzlD)) b2683(probable L-valine exporter, norvaline resistance) BN373_36501(conserved hypothetical protein) Cluster4201 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1098(Inner membrane protein YgaZ,azaleucine resistance protein AzlC,AzlC protein) b2682(probable L-valine exporter, norvaline resistance) BN373_36491(AzlC family protein) Cluster4202 0 0 0 0 1 1 1 BN373_36411(carboxymuconolactone decarboxylase family protein) t2700(conserved hypothetical protein) SL1344_2788(conserved hypothetical protein) Cluster4203 0 1 0 0 1 0 1 ENC_44420(transcriptional regulator, GntR family) BN373_36401(transcriptional regulator, GntR family/aminotransferase family protein) SL1344_2787(putative transcriptional regulator) Cluster4204 0 1 0 0 1 1 0 ENC_29170(hypothetical protein) BN373_36341(conserved hypothetical protein) t2694(hypothetical protein) Cluster4205 0 0 0 0 1 1 1 BN373_36331(beta-hydroxylase, aspartyl/asparaginyl family) t4193(putative membrane-bound beta-hydroxylase) SL1344_4223(putative membrane-bound beta-hydroxylase) Cluster4206 0 1 0 0 1 0 1 ENC_37630(RND family efflux transporter, MFP subunit) BN373_36071(RND multidrug efflux membrane fusion protein OqxA) SL1344_0347(putative cation efflux pump) Cluster4207 0 0 0 0 1 1 1 BN373_36001(conserved hypothetical protein) t4522(phage polarity suppression protein) SL1344_2716(bacteriophage polarity suppression protein) Cluster4208 0 0 0 0 1 1 1 BN373_35091(conserved hypothetical protein) t0322(hypothetical protein) SL1344_2496(hypothetical protein) Cluster4209 0 0 0 0 1 1 1 BN373_34921(putative phosphatase/sulfatase) t0086(puatative sulfatase) SL1344_0084(putative sulfatase) Cluster4210 0 0 0 0 1 1 1 BN373_34241(conserved hypothetical protein) t0422(hypothetical protein) SL1344_2397(hypothetical protein) Cluster4211 0 0 2 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1811(Crossover junction endodeoxyribonuclease rusA,endodeoxyribonuclease RUS,Holliday junction resolvase,Endodeoxyribonuclease RusA),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2563(Crossover junction endodeoxyribonuclease rusA,endodeoxyribonuclease RUS,Holliday junction resolvase,Endodeoxyribonuclease RusA) BN373_33791(crossover junction endodeoxyribonuclease RusA) Cluster4212 0 0 0 0 1 1 1 BN373_33721(chitinase) t1899(putative bacteriophage protein) SL1344_1956(putative bacteriophage encoded lysozyme) Cluster4213 0 0 1 0 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1823(HNH endonuclease) BN373_33661(HNH endonuclease domain protein) SL1344_1952(predicted bacteriophage protein) Cluster4214 0 0 1 0 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1829(Predicted phage phi-C31 gp36 major capsid-like protein,phage major capsid protein, HK97 family,Phage capsid family) BN373_33611(phage major capsid protein, HK97 family) SL1344_1947(capsid related protein) Cluster4215 0 0 1 0 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1830(uncharacterized phage protein (possible DNA packaging),Phage gp6-like head-tail connector protein) BN373_33591(conserved hypothetical protein) SL1344_1945(predicted bacteriophage protein) Cluster4216 0 0 2 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1831(Bacteriophage head-tail adaptor,putative phage head-tail adaptor,Phage head-tail joining protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2539(Bacteriophage head-tail adaptor,Phage head-tail joining protein) BN373_33571(head-tail adaptor) Cluster4217 1 1 0 0 1 0 0 ROD_27131(putative acetyltransferase) ENC_39030(Acetyltransferases, including N-acetylases of ribosomal proteins) BN373_33051(acetyltransferase, GNAT family) Cluster4218 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1483(Acetyl-CoA acetyltransferase,putative acyltransferase,Transcription-associated recombination protein,acetyl-CoA C-acetyltransferase,Thiolase, N-terminal domain) b2224(acetyl-CoA acetyltransferase) BN373_32501(acetyl-CoA acetyltransferase) Cluster4219 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1484(Short-chain fatty acids transporter,conserved hypothetical protein,Short chain fatty acid transporter) b2223(short chain fatty acid transporter) BN373_32491(short chain fatty acid transporter) Cluster4220 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1485(Acetate CoA-transferase subunit beta,Acyl CoA:acetate/3-ketoacid CoA transferase,3-oxoacid CoA-transferase, B subunit,Coenzyme A transferase) b2222(acetyl-CoA:acetoacetyl-CoA transferase, beta subunit) BN373_32481(Acetate CoA-transferase subunit beta) Cluster4221 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1487(Transcriptional regulatory protein ZraR,acetoacetate metabolism regulatory protein AtoC,Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,nitrogen regulation protein NR(I),Sigma-54 interaction domain) b2220(fused response regulator of ato operon, in two-component system with AtoS: response regulator/sigma54 interaction protein) BN373_32461(acetoacetate metabolism regulatory protein AtoC) Cluster4222 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1488(Sensor protein ZraS,sensory histidine kinase AtoS,Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation,phosphate regulon sensor kinase PhoR,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) b2219(sensory histidine kinase in two-component regulatory system with AtoC) BN373_32451(sensory histidine kinase AtoS) Cluster4223 1 1 0 0 1 0 0 ROD_23431(magnesium transporter) ENC_39740(Mg2+ transporter (mgtE)) BN373_32361(magnesium transporter) Cluster4224 0 1 0 0 1 1 0 ENC_10510(transcriptional regulator, DeoR family) BN373_32281(transcriptional regulator, DeoR family) t4122(deoR family regulatory protein) Cluster4225 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4796(Cryptic beta-glucoside bgl operon antiterminator,transcriptional antiterminator BglG,Transcriptional antiterminator,PRD domain) b3723(transcriptional antiterminator of the bgl operon) BN373_31811(cryptic beta-glucoside bgl operon antiterminator) Cluster4226 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4797(EIIBCA-Bgl,PTS system beta-glucoside-specific transporter subunits IIABC,PTS system, beta-glucoside-specific IIABC component,phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1) b3722(fused beta-glucoside-specific PTS enzymes: IIA component/IIB component/IIC component) BN373_31801(PTS system, beta-glucoside-specific EIIBCA component) Cluster4227 1 1 0 0 1 0 0 ROD_22531(putative acetyltransferase) ENC_40330(Sortase and related acyltransferases) BN373_31741(putative phosphinothricin N-acetyltransferase) Cluster4228 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4850(Adenine deaminase,cryptic adenine deaminase,N-acyl-D-aspartate/D-glutamate deacylase,adenine deaminase,Amidohydrolase family) b3665(cryptic adenine deaminase) BN373_31571(putative adenine deaminase) Cluster4229 1 1 0 0 1 0 0 ROD_24851(putative carbohydrate kinase) ENC_23260(FGGY-family pentulose kinase) BN373_31501(ribulokinase) Cluster4230 1 1 0 0 1 0 0 ROD_22211(putative mandelate racemase/muconate lactonising enzyme) ENC_40760(L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily) BN373_31421(mandelate racemase/muconate lactonizing enzyme family protein) Cluster4231 1 1 0 0 1 0 0 ROD_22201(ABC transporter, substrate binding protein) ENC_40770(ABC-type dipeptide transport system, periplasmic component) BN373_31411(ABC transporter, periplasmic substrate-binding protein) Cluster4232 1 1 0 0 1 0 0 ROD_22181(ABC transporter, permease protein) ENC_40800(ABC-type dipeptide/oligopeptide/nickel transport systems, permease components) BN373_31391(ABC transporter, permease protein) Cluster4233 1 1 0 0 1 0 0 ROD_22171(ABC transporter ATP binding protein) ENC_40810(ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component) BN373_31381(ABC transporter, ATP-binding protein) Cluster4234 1 1 0 0 1 0 0 ROD_19391(putative sodium/dicarboxylate symporter) ENC_06000(Na+/H+-dicarboxylate symporters) BN373_31281(transporter, dicarboxylate/amino acid:cation (Na+ or H+) symporter (DAACS) family) Cluster4235 1 0 1 0 1 0 0 ROD_21681(glycosyltransferase WfaO) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1678(Lipopolysaccharide core biosynthesis protein rfaG,lipopolysaccharide 1,2-N-acetylglucosaminetransferase,Glycogen synthase,glycogen synthase, Corynebacterium family,Glycosyl transferases group 1) BN373_31121(glycosyl transferase group 1) Cluster4236 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1680(Galactoside O-acetyltransferase,putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ,Acetyltransferase (isoleucine patch superfamily),phosphonate metabolim protein, transferase hexapeptide repeat family,Bacterial transferase hexapeptide (six repeats)) b2033(predicted lipopolysaccharide biosynthesis O-acetyl transferase) BN373_31061(uncharacterized 24.8 kda protein in cps region altname: full=orf13) Cluster4237 0 1 0 0 1 1 0 ENC_41400(Nucleoside-diphosphate-sugar epimerases) BN373_30981(putative uridine diphosphate galacturonate 4-epimerase) t4351(Vi polysaccharide biosynthesis protein, epimerase) Cluster4238 0 0 1 0 1 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.755(Polysialic acid transport protein kpsM,Vi polysaccharide export inner membrane protein VexB,ABC-2 type transporter) BN373_30971(lipopolysaccharide O-antigen ABC transport system transmembrane component) t4347(Vi polysaccharide export inner-membrane protein) Cluster4239 0 0 0 0 1 1 1 BN373_30931(putative glycosyltransferase) t2156(putative glycosyl transferase) SL1344_0702(putative glycosyl transferase) Cluster4240 0 0 0 0 1 1 1 BN373_30911(bifunctional galactosyltransferase) t2155(galactosyltransferase) SL1344_0703(galactosyltransferase) Cluster4241 1 0 1 0 1 0 0 ROD_20671(integrase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1787(Prophage CP4-57 integrase,integrase,Site-specific recombinase XerD,Phage integrase family) BN373_30291(integrase) Cluster4242 1 1 0 0 1 0 0 ROD_31441(putative exported protein) ENC_10120(Lysophospholipase) BN373_30251(conserved hypothetical protein) Cluster4243 1 1 0 0 1 0 0 ROD_19571(putative Major Facilitator Superfamily transporter) ENC_05820(Arabinose efflux permease) BN373_29861(transporter, major facilitator family) Cluster4244 1 1 0 0 1 0 0 ROD_19221(putative MFS transmembrane transporter) ENC_06170(Na+/melibiose symporter and related transporters) BN373_29761(oligogalacturonide transporter) Cluster4245 1 1 0 0 1 0 0 ROD_27981(putative cold-shock protein) ENC_21660(cold-shock DNA-binding protein family) BN373_28581(cold-shock DNA-binding domain protein) Cluster4246 0 1 1 0 1 0 0 ENC_09090(type VI secretion system lysozyme-related protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.930(type VI secretion system lysozyme-like protein,Gene 25-like lysozyme) BN373_28411(type VI secretion system lysozyme-related protein) Cluster4247 1 0 1 0 1 0 0 pseudoROD_50031(conserved hypothetical protein (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.929(Uncharacterized protein conserved in bacteria,type VI secretion-associated protein, VC_A0119 family,ImpA domain protein) BN373_28401(ImpA domain protein) Cluster4248 1 1 0 0 1 0 0 ROD_17941(conserved hypothetical protein) ENC_07690(Domain of unknown function (DUF1883).) BN373_28201(conserved hypothetical protein) Cluster4249 1 1 0 0 1 0 0 ROD_17921(nitrate-and nitrite-responsive positive regulator) ENC_07730(Response regulator with putative antiterminator output domain) BN373_28181(nitrate regulatory protein) Cluster4250 1 1 0 0 1 0 0 ROD_17911(nitrate-binding protein) ENC_07750(ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components) BN373_28171(nitrate ABC transporter, periplasmic nitrate-binding protein) Cluster4251 1 1 0 0 1 0 0 ROD_17901(nitrate transporter permease component) ENC_07760(nitrate ABC transporter, permease protein) BN373_28161(nitrate ABC transporter, permease protein) Cluster4252 1 1 0 0 1 0 0 ROD_17891(nitrate transport protein) ENC_07770(nitrate transport ATP-binding subunits C and D) BN373_28151(nitrate ABC transporter, ATP-binding protein) Cluster4253 1 1 0 0 1 0 0 ROD_17871(nitrate reductase) ENC_07790(assimilatory nitrate reductase (NADH) alpha subunit apoprotein) BN373_28131(nitrate reductase) Cluster4254 0 0 0 0 1 1 1 BN373_27881(transporter, cation channel family) t1653(possible membrane transport protein) SL1344_1672(possible ion transport protein) Cluster4255 1 0 0 1 1 0 0 ROD_17581(conserved hypothetical protein) b4595(hypothetical protein) BN373_27851(conserved hypothetical protein) Cluster4256 1 1 0 0 1 0 0 ROD_13351(putative exported protein) ENC_14200(hypothetical protein) BN373_27671(conserved hypothetical protein) Cluster4257 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4243(HTH-type transcriptional repressor KstR2,HTH-type transcriptional regulator RutR,transcriptional repressor BetI,Bacterial regulatory proteins, tetR family) pseudob4205(unknown) BN373_27161(transcriptional regulator, TetR family) Cluster4258 0 0 1 0 1 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4245(Hydroxypyruvate isomerase,Xylose isomerase-like TIM barrel) BN373_27151(AP endonuclease, family 2/4-hydroxyphenylpyruvate dioxygenase) SL1344_4359(myo-inositol catabolism protein) Cluster4259 0 0 0 0 1 1 1 BN373_27121(putative molybdate ABC transporter, periplasmic molybdate-binding protein) t3062(hypothetical protein) SL1344_3115(hypothetical protein) Cluster4260 0 0 0 0 1 1 1 BN373_27091(iron chelate ABC transporter, periplasmic iron chelate-binding protein) t3063(possible ABC-transport protein, periplasmic-binding component) SL1344_3116(possible ABC-transport protein, periplasmic-binding component) Cluster4261 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3625(YiaKLMNOPQRS operon repressor,DNA-binding transcriptional activator MhpR,beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family,IclR helix-turn-helix domain) b0346(DNA-binding transcriptional activator, 3HPP-binding) BN373_27081(Mhp operon transcriptional activator) Cluster4262 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3623(2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnam ic acid 1,2-dioxygenase,3-(2,3-dihydroxyphenyl)propionate dioxygenase,Uncharacterized conserved protein,Catalytic LigB subunit of aromatic ring-opening dioxygenase) b0348(2,3-dihydroxyphenylpropionate 1,2-dioxygenase) BN373_27061(2,3-dihydroxyphenylpropionate 1,2-dioxygenase) Cluster4263 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3621(2-keto-4-pentenoate hydratase,2-keto-4-pentenoate hydratase,2-keto-4-pentenoate hydratase,2-oxopent-4-enoate hydratase,Fumarylacetoacetate (FAA) hydrolase family) b0350(2-keto-4-pentenoate hydratase) BN373_27041(2-keto-4-pentenoate hydratase) Cluster4264 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3620(Acetaldehyde dehydrogenase,acetaldehyde dehydrogenase,Acetaldehyde dehydrogenase (acetylating),acetaldehyde dehydrogenase (acetylating),Prokaryotic acetaldehyde dehydrogenase, dimerisation) b0351(acetaldehyde-CoA dehydrogenase II, NAD-binding) BN373_27031(acetaldehyde dehydrogenase) Cluster4265 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3619(4-hydroxy-2-oxovalerate aldolase,4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,,Isopropylmalate/homocitrate/citramalate synthases,4-hydroxy-2-oxovalerate aldolase,HMGL-like) b0352(4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase, class I) BN373_27021(4-hydroxy-2-oxovalerate aldolase) Cluster4266 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3618(4-hydroxybenzoate transporter PcaK,putative 3-hydroxyphenylpropionic transporter MhpT,Arabinose efflux permease,MFS transporter, aromatic acid:H+ symporter (AAHS) family,Major Facilitator Superfamily) b0353(predicted 3-hydroxyphenylpropionic transporter) BN373_27011(putative 3-hydroxyphenylpropionic acid transporter MhpT) Cluster4267 0 1 1 0 1 0 0 ENC_32720(TonB-dependent siderophore receptor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.667(Ferric hydroxamate uptake,ferrichrome receptor precursor protein,Outer membrane receptor for monomeric catechols,TonB-dependent siderophore receptor,TonB dependent receptor) BN373_26901(TonB-dependent siderophore receptor) Cluster4268 0 1 1 0 1 0 0 ENC_32690(ABC-type Fe3+-siderophore transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.669(Probable siderophore transport system permease protein yfiZ precursor,iron-hydroxamate transporter permease subunit,ABC-type Fe3+-siderophore transport system, permease component,proposed F420-0 ABC transporter, permease protein,FecCD transport family) BN373_26881(iron ABC transporter, permease protein) Cluster4269 0 1 1 0 1 0 0 ENC_32680(ABC-type Fe3+-siderophore transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.670(Iron-uptake system permease protein FeuC,iron-hydroxamate transporter permease subunit,ABC-type Fe3+-siderophore transport system, permease component,proposed F420-0 ABC transporter, permease protein,FecCD transport family) BN373_26871(iron ABC transporter, permease protein) Cluster4270 0 1 1 0 1 0 0 ENC_32670(ABC-type Fe3+-hydroxamate transport system, periplasmic component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.671(Iron(III)-hydroxamate-binding protein fhuD,iron-enterobactin transporter periplasmic binding protein,ABC-type Fe3+-citrate transport system, periplasmic component,Periplasmic binding protein) BN373_26861(iron ABC transporter, periplasmic iron-binding protein) Cluster4271 0 1 1 0 1 0 0 ENC_32660(Transcriptional regulators) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.672(Uncharacterized HTH-type transcriptional regulator ybbH,bifunctional glucokinase/RpiR family transcriptional regulator,SIS domain) BN373_26851(SIS domain protein) Cluster4272 0 0 0 0 1 1 1 BN373_26811(unknown) t4552(hypothetical protein) SL1344_4432(hypothetical protein) Cluster4273 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3197(Uncharacterized oxidoreductase ybiC,putative dehydrogenase,Malate/L-lactate dehydrogenases,ureidoglycolate dehydrogenase,Malate/L-lactate dehydrogenase) b0801(predicted dehydrogenase) BN373_26741(malate/L-lactate dehydrogenase) Cluster4274 0 1 0 0 2 0 0 ENC_16250(Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.) BN373_26701(glyoxalase family protein),BN373_26781(glyoxalase family protein) Cluster4275 1 0 0 0 1 0 1 pseudoROD_15511(putative citrate transporter (fragment)) BN373_26451(citrate transporter family protein) SL1344_0836(putative inner membrane protein) Cluster4276 0 1 0 1 1 0 0 ENC_10050(oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain) b1484(D,D-dipeptide permease system, ATP-binding component) BN373_26061(oligopeptide ABC transport system ATP-binding component) Cluster4277 0 1 0 1 1 0 0 ENC_13450(Carbonic anhydrase) b0339(carbonic anhydrase) BN373_25981(carbonate dehydratase) Cluster4278 1 1 0 0 1 0 0 ROD_27621(conserved hypothetical protein) ENC_10300(Zn-dependent hydrolases, including glyoxylases) BN373_25921(beta-lactamase domain protein) Cluster4279 1 1 0 0 1 0 0 ROD_16011(putative AraC-family transcriptional regulator) ENC_11000(hypothetical protein) BN373_25181(transcriptional regulator, AraC family) Cluster4280 1 1 0 0 1 0 0 ROD_15821(putative DNA-binding protein) ENC_09450(hypothetical protein) BN373_24901(DNA-binding protein) Cluster4281 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4580(hypothetical protein,hypothetical protein,conserved hypothetical protein,Protein of unknown function (DUF406)) b3922(conserved protein, UPF0381 family) BN373_24871(conserved hypothetical protein) Cluster4282 0 0 0 0 1 1 1 BN373_24831(putative lipoprotein) t1495(putative lipoprotein) SL1344_1516(putative lipoprotein) Cluster4283 1 0 0 1 1 0 0 ROD_15761(putative glutathione S-transferase) b1454(glutathione S-transferase homolog) BN373_24711(glutathione S-transferase domain protein) Cluster4284 0 1 0 1 1 0 0 ENC_09640(Uncharacterized protein, 4-oxalocrotonate tautomerase homolog) b1461(4-oxalocrotonate tautomerase) BN373_24701(tautomerase enzyme family protein) Cluster4285 0 0 0 0 1 1 1 BN373_24511(2-chlorobenzoate 1,2-dioxygenase, electron transfer subunit) t0779(putative reductase RfbI) SL1344_2070(putative reductase RfbI) Cluster4286 1 1 0 0 1 0 0 ROD_13951(putative short-chain dehydrogenase) ENC_31060(Short-chain dehydrogenases of various substrate specificities) BN373_24161(oxidoreductase, short chain dehydrogenase/reductase family) Cluster4287 1 1 0 0 1 0 0 ROD_14931(putative membrane protein) ENC_31080(Predicted membrane protein) BN373_24141(conserved hypothetical protein) Cluster4288 1 1 0 0 1 0 0 ROD_14941(putative membrane protein) ENC_31090(hypothetical protein) BN373_24131(conserved hypothetical protein) Cluster4289 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2337(Formate dehydrogenase H,putative oxidoreductase,Uncharacterized anaerobic dehydrogenase,oxidoreductase alpha (molybdopterin) subunit,Molybdopterin oxidoreductase) b1501(predicted oxidoreductase) BN373_24041(molybdopterin oxidoreductase, alpha subunit) Cluster4290 0 1 0 0 1 0 1 ENC_10570(Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)) BN373_23871(hydrolase, alpha/beta fold family) SL1344_0327(putative hydrolase or acyltransferase) Cluster4291 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.872(Guanine deaminase,guanine deaminase,Cytosine deaminase and related metal-dependent hydrolases,guanine deaminase,Amidohydrolase family) b2883(guanine deaminase) BN373_23651(guanine deaminase) Cluster4292 0 0 0 0 1 1 1 BN373_23611(putative urate catabolism protein) t3053(conserved hypothetical protein) SL1344_3106(conserved hypothetical protein) Cluster4293 0 0 0 0 1 1 1 BN373_23561(class I glutamine amidotransferase family protein) t0420(putative amidotransferase) SL1344_2400(putative amidotransferase) Cluster4294 0 0 0 0 1 1 1 BN373_23301(transporter, major facilitator family) t2508(putative metabolite transport protein) SL1344_0351(putative metabolite transport protein) Cluster4295 0 0 0 0 1 1 1 BN373_22991(phosphoglycerate transporter protein) t0459(phosphoglycerate transporter protein) SL1344_2367(phosphoglycerate transporter protein) Cluster4296 0 0 0 0 1 1 1 BN373_22981(phosphoglycerate transport system regulatory protein) t0460(phosphoglycerate transport regulatory protein PgtC precursor) SL1344_2366(phosphoglycerate transport regulatory protein PgtC precursor) Cluster4297 0 0 0 0 1 1 1 BN373_22961(phosphoglycerate transport system activator protein) t0462(phosphoglycerate transport system transcriptional regulatory protein PgtA) SL1344_2364(phosphoglycerate transport system transcriptional regulatory protein PgtA) Cluster4298 0 0 0 0 3 0 0 BN373_22831(LysR family transcriptional regulator),BN373_22861(LysR family transcriptional regulator),BN373_26131(transcriptional regulator, LysR family) Cluster4299 1 0 0 0 1 0 1 ROD_12461(LysR-family transcriptional regulator) BN373_22671(transcriptional regulator LysR) SL1344_0835(LysR transcriptional regulator) Cluster4300 1 1 0 0 1 0 0 ROD_18151(putative fimbrial adhesin) ENC_13810(P pilus assembly protein, pilin FimA) BN373_22501(putative fimbrial protein) Cluster4301 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2329(Serine/threonine-protein kinase HipA,putative DNA-binding transcriptional regulator,Uncharacterized protein related to capsule biosynthesis enzymes,HipA N-terminal domain,HipA-like N-terminal domain) b1507(serine protein kinase required for perister formation; toxin of HipAB toxin-antitoxin system) BN373_22481(protein HipA) Cluster4302 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2328(Antitoxin HipB,antitoxin HipB,transcriptional regulator, y4mF family,Helix-turn-helix) b1508(antitoxin of HipAB toxin-antitoxin system) BN373_22471(transcriptional regulator HipB) Cluster4303 0 0 0 0 3 0 0 BN373_22341(oxidoreductase, 2OG-Fe(II) oxygenase family),BN373_26191(oxidoreductase, 2OG-Fe(II) oxygenase family),BN373_36131(oxidoreductase, 2OG-Fe(II) oxygenase family) Cluster4304 1 1 0 0 1 0 0 ROD_13781(putative ABC transporter outer membrane protein) ENC_13550(ABC-type metal ion transport system, periplasmic component/surface antigen) BN373_22331(methionine uptake ABC transporter (MUT) family, periplasmic methionine-binding protein) Cluster4305 0 0 0 0 3 0 0 BN373_22191(conserved hypothetical protein),BN373_22221(conserved hypothetical protein),BN373_30621(malonate-semialdehyde dehydrogenase (acetylating)) Cluster4306 1 0 1 0 1 0 0 ROD_15161(putative alcohol dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3319(1,3-propanediol dehydrogenase,L-1,2-propanediol oxidoreductase,Glycerol dehydrogenase and related enzymes,lactaldehyde reductase,Iron-containing alcohol dehydrogenase) BN373_22041(putative 5-hydroxyvalerate dehydrogenase) Cluster4307 1 0 1 0 1 0 0 ROD_15151(putative dihydrodipicolinate synthase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3320(Dihydrodipicolinate synthase,dihydrodipicolinate synthase,dihydrodipicolinate synthase,Dihydrodipicolinate synthetase family) BN373_22031(putative dihydrodipicolinate synthase) Cluster4308 1 0 1 0 1 0 0 ROD_15131(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3322(Predicted neuraminidase (sialidase)) BN373_22011(glycosyl hydrolase, BNR repeat protein) Cluster4309 1 1 0 0 1 0 0 ROD_15031(putative ABC transport ATP-binding subunit) ENC_10850(amino acid/amide ABC transporter ATP-binding protein 2, HAAT family (TC 3.A.1.4.-)) BN373_21881(urea ABC transporter, ATP-binding protein UrtE) Cluster4310 1 1 0 0 1 0 0 ROD_15021(putative ABC transport ATP-binding subunit) ENC_10860(urea ABC transporter, ATP-binding protein UrtD) BN373_21871(urea ABC transporter, ATP-binding protein UrtD) Cluster4311 1 1 0 0 1 0 0 ROD_15011(putative branched-chain amino acid transport system, permease component) ENC_10870(amino acid/amide ABC transporter membrane protein 2, HAAT family (TC 3.A.1.4.-)) BN373_21861(urea ABC transporter, permease protein UrtC) Cluster4312 1 1 0 0 1 0 0 ROD_15001(putative branched-chain amino acid transport system, permease component) ENC_10880(amino acid/amide ABC transporter membrane protein 1, HAAT family (TC 3.A.1.4.-)) BN373_21851(urea ABC transporter, permease protein UrtB) Cluster4313 1 1 0 0 1 0 0 ROD_14991(putative substrate-binding periplasmic transport protein) ENC_10890(amino acid/amide ABC transporter substrate-binding protein, HAAT family (TC 3.A.1.4.-)) BN373_21841(urea ABC transporter, urea binding protein) Cluster4314 1 1 0 0 1 0 0 ROD_14981(putative methionine synthase) ENC_10900(Methionine synthase II (cobalamin-independent)) BN373_21831(methionine synthase, vitamin-B12 independent family protein) Cluster4315 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1035(Inner membrane permease ygbN,putative transporter,H+/gluconate symporter and related permeases,transporter, gluconate:H+ symporter (GntP) family,GntP family permease) b2740(predicted transporter) BN373_21591(transporter, gluconate:H+ symporter (GntP) family) Cluster4316 1 1 0 0 1 0 0 ROD_44571(putative malonate decarboxylase acyl carrier protein transferase MdcA) ENC_25620(malonate decarboxylase, alpha subunit) BN373_21191(malonate decarboxylase, alpha subunit) Cluster4317 1 1 0 0 1 0 0 ROD_44581(putative 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase) ENC_25610(triphosphoribosyl-dephospho-CoA synthase MdcB) BN373_21181(triphosphoribosyl-dephospho-CoA synthase MdcB) Cluster4318 1 1 0 0 1 0 0 ROD_44591(putative malonate decarboxylase acyl carrier protein) ENC_25600(malonate decarboxylase acyl carrier protein) BN373_21171(malonate decarboxylase, delta subunit) Cluster4319 1 1 0 0 1 0 0 ROD_44601(putative malonate decarboxylase beta subunit MdcD) ENC_25590(malonate decarboxylase, beta subunit) BN373_21161(malonate decarboxylase, beta subunit) Cluster4320 1 1 0 0 1 0 0 ROD_44611(putative malonate decarboxylase gamma subunit MdcE) ENC_25580(malonate decarboxylase, gamma subunit) BN373_21151(malonate decarboxylase, gamma subunit) Cluster4321 1 1 0 0 1 0 0 ROD_44621(putative malonate transporter MdcF) ENC_25570(he Auxin Efflux Carrier (AEC) Family) BN373_21141(malonate transporter MdcF) Cluster4322 1 1 0 0 1 0 0 ROD_44631(putative phosphoribosyl-dephospho-CoA transferase) ENC_25560(holo-ACP synthase, malonate decarboxylase-specific) BN373_21131(holo-ACP synthase, malonate decarboxylase-specific) Cluster4323 1 1 0 0 1 0 0 ROD_44641(putative malonyl-CoA: acyl carier protein-SH transacylase MdcH) ENC_25550(malonate decarboxylase, epsilon subunit) BN373_21121(unknown) Cluster4324 0 1 1 0 1 0 0 ENC_41960(flavocytochrome c) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3675(NADH oxidase,NADPH dehydrogenase NamA,mycofactocin system FadH/OYE family oxidoreductase 2,NADH:flavin oxidoreductase / NADH oxidase family) BN373_21041(oxidoreductase, FAD/FMN-binding/flavocytochrome c) Cluster4325 0 1 0 1 1 0 0 ENC_12610(Transcriptional regulator) b1339(predicted DNA-binding transcriptional regulator of abgABT operon) BN373_20921(putative HTH-type transcriptional regulator abgR) Cluster4326 0 1 0 1 1 0 0 ENC_12620(amidohydrolase) b1338(p-aminobenzoyl-glutamate hydrolase, A subunit) BN373_20911(aminobenzoyl-glutamate utilization protein A) Cluster4327 0 1 0 1 1 0 0 ENC_12630(amidohydrolase) b1337(p-aminobenzoyl-glutamate hydrolase, B subunit) BN373_20901(aminobenzoyl-glutamate utilization protein B) Cluster4328 0 1 0 1 1 0 0 ENC_11580(phenylacetic acid degradation operon negative regulatory protein PaaX) b1399(DNA-binding transcriptional repressor of phenylacetic acid degradation paa operon, phenylacetyl-CoA inducer) BN373_20351(phenylacetic acid degradation operon negative regulatory protein PaaX) Cluster4329 0 1 0 1 1 0 0 ENC_11600(Coenzyme F390 synthetase) b1398(phenylacetyl-CoA ligase) BN373_20341(phenylacetate-CoA ligase PaaK) Cluster4330 0 1 0 1 1 0 0 ENC_11620(phenylacetic acid degradation protein PaaD) b1396(thioesterase, most active with ring-hydroxylated phenylacetyl-coenzyme A thioesters) BN373_20321(phenylacetic acid degradation protein PaaI) Cluster4331 0 1 0 1 1 0 0 ENC_11630(3-hydroxyacyl-CoA dehydrogenase) b1395(3-hydroxyadipyl-CoA dehydrogenase, NAD+-dependent) BN373_20311(3-hydroxybutyryl-CoA dehydrogenase PaaH) Cluster4332 0 1 0 1 1 0 0 ENC_11680(phenylacetate-CoA oxygenase, PaaJ subunit) b1391(ring 1,2-phenylacetyl-CoA epoxidase subunit) BN373_20271(phenylacetate-CoA oxygenase, gamma subunit) Cluster4333 0 1 0 1 1 0 0 ENC_11690(phenylacetate-CoA oxygenase, PaaI subunit) b1390(ring 1,2-phenylacetyl-CoA epoxidase subunit) BN373_20261(phenylacetate-CoA oxygenase, beta subunit) Cluster4334 0 1 0 1 1 0 0 ENC_11700(phenylacetate-CoA oxygenase, PaaH subunit) b1389(ring 1,2-phenylacetyl-CoA epoxidase possible subunit, not required for in vitro activity) BN373_20251(phenylacetate-CoA oxygenase, effector protein) Cluster4335 0 1 0 1 1 0 0 ENC_11710(phenylacetate-CoA oxygenase, PaaG subunit) b1388(ring 1,2-phenylacetyl-CoA epoxidase subunit) BN373_20241(phenylacetyl-CoA oxygenase, alpha subunit) Cluster4336 0 0 0 0 1 1 1 BN373_19831(ABC transporter, periplasmic substrate-binding protein) t2350(lipoprotein) SL1344_0503(lipoprotein) Cluster4337 0 0 0 0 1 1 1 BN373_19771(transcriptional regulator, LysR family) t3782(putative regulatory protein) SL1344_3702(putative regulatory protein) Cluster4338 0 0 0 0 1 1 1 BN373_19761(transcriptional regulator, LysR family) t1581(putative transcriptional regulator) SL1344_1607(putative transcriptional regulator) Cluster4339 0 0 0 0 1 1 1 BN373_19751(NmrA family protein) t1582(putative oxidoreductase) SL1344_1608(putative oxidoreductase) Cluster4340 0 0 1 0 2 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.931(Uncharacterized protein conserved in bacteria,type VI secretion lipoprotein, VC_A0113 family,Type VI secretion lipoprotein) BN373_19681(conserved hypothetical protein),BN373_28421(type VI secretion lipoprotein, VC_A0113 family) Cluster4341 0 1 1 0 1 0 0 ENC_09070(type VI secretion protein, VC_A0111 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.932(Uncharacterized protein conserved in bacteria,type VI secretion protein, VC_A0111 family,Protein of unknown function (DUF1305)) BN373_19671(conserved hypothetical protein) Cluster4342 0 1 1 0 1 0 0 ENC_09050(type VI secretion-associated protein, VC_A0119 family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.936(Uncharacterized protein conserved in bacteria,type VI secretion-associated protein, VC_A0119 family,ImpA-related N-terminal) BN373_19651(type VI secretion-associated protein, VC_A0119 family) Cluster4343 0 0 1 0 2 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.937(Uncharacterized protein conserved in bacteria,type VI secretion protein IcmF,Intracellular multiplication and human macrophage-killing) BN373_19641(ImcF domain protein),BN373_28451(ImcF-related family protein) Cluster4344 0 0 0 0 3 0 0 BN373_19581(putative lipoprotein),BN373_19591(lipoprotein),BN373_19601(lipoprotein) Cluster4345 0 1 1 0 1 0 0 ENC_08930(type IV / VI secretion system protein, DotU family) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.954(hypothetical protein,Uncharacterized protein conserved in bacteria,type IV/VI secretion system protein, DotU family,Uncharacterized protein conserved in bacteria (DUF2077)) BN373_19521(type IV/VI secretion system protein, DotU family) Cluster4346 1 1 0 0 1 0 0 ROD_30381(Major Facilitator Superfamily transporter) ENC_30170(Sugar phosphate permease) BN373_19221(transporter, major facilitator family) Cluster4347 1 1 0 0 1 0 0 ROD_30401(putative transcriptional regulator) ENC_30140(Beta-xylosidase) BN373_19201(transcriptional regulator, AraC family) Cluster4348 0 0 0 0 1 1 1 BN373_18781(transcriptional regulator, MarR family) t1466(putative regulatory protein) SL1344_1476(putative regulatory protein) Cluster4349 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3193(TonB-dependent receptor Fiu,catecholate siderophore receptor Fiu,Outer membrane receptor for monomeric catechols,TonB-dependent siderophore receptor,TonB dependent receptor) b0805(catecholate siderophore receptor Fiu) BN373_18731(catecholate siderophore receptor Fiu) Cluster4350 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3194(PKHD-type hydroxylase Sbal_3634,Fe(II)-dependent oxygenase superfamily protein,Uncharacterized iron-regulated protein) b0804(conserved protein, Fe(II)-dependent oxygenase superfamily) BN373_18721(oxidoreductase, 2OG-Fe(II) oxygenase family) Cluster4351 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2128(TVP38/TMEM64 family inner membrane protein ydjZ,SNARE associated Golgi protein) b1752(Inner membrane protein, TVP38/TMEM64 family) BN373_18411(putative membrane protein) Cluster4352 0 0 0 0 1 1 1 BN373_18291(PAP2 family protein) t4225(nonspecific acid phosphatase precursor) SL1344_4255(nonspecific acid phosphatase precursor) Cluster4353 1 1 0 0 1 0 0 ROD_12771(putative exported protein) ENC_14730(Chitinase) BN373_18231(putative chitinase II) Cluster4354 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.62(lipopolysaccharide heptosyltransferase I,Glycosyltransferase family 9 (heptosyltransferase)) b3623(lipopolysaccharide core biosynthesis) BN373_18031(heptosyltransferase family protein) Cluster4355 1 1 0 0 1 0 0 ROD_12641(conserved hypothetical protein) ENC_14890(CTP synthase (UTP-ammonia lyase)) BN373_17981(class I glutamine amidotransferase family protein) Cluster4356 0 1 0 1 1 0 0 ENC_14940(hypothetical protein) b4676(expressed protein, membrane-associated) BN373_17931(conserved hypothetical protein) Cluster4357 1 0 0 0 1 0 1 ROD_42981(L-asparginase) BN373_17881(L-asparaginase 2) SL1344_3563(L-asparginase) Cluster4358 1 1 0 0 1 0 0 ROD_33851(conserved hypothetical protein) ENC_44440(Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides) BN373_17701(antibiotic biosynthesis monooxygenase domain protein) Cluster4359 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2794(Inner membrane protein ymfA,Protein of unknown function (DUF3592)) b1122(conserved inner membrane protein) BN373_17451(predicted inner membrane protein) Cluster4360 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2795(Inner membrane protein ycfZ) b1121(inner membrane protein) BN373_17441(putative inner membrane protein) Cluster4361 1 0 1 0 1 0 0 ROD_50561(putative 2-keto-3-deoxygluconate permease) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.153(2-keto-3-deoxygluconate permease,2-keto-3-deoxygluconate permease,2-keto-3-deoxygluconate transporter,2-keto-3-deoxygluconate permease) BN373_17371(2-keto-3-deoxygluconate permease) Cluster4362 0 1 1 0 1 0 0 ENC_03370(Transcriptional regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2474(Uncharacterized HTH-type transcriptional regulator yfiR,transcriptional regulator BetI,transcriptional repressor BetI,Bacterial regulatory proteins, tetR family) BN373_16751(transcriptional regulator, TetR family) Cluster4363 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2263(HTH-type transcriptional repressor KstR2,DNA-binding transcriptional repressor AcrR,pyrimidine utilization regulatory protein R,Bacterial regulatory proteins, tetR family) b1618(DNA-binding transcriptional repressor) BN373_16681(transcriptional regulator, TetR family) Cluster4364 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2897(Pyrimidine monooxygenase RutA,alkanesulfonate monooxygenase,pyrimidine utilization protein A,Luciferase-like monooxygenase) b1012(pyrimidine oxygenase, FMN-dependent) BN373_16531(putative monooxygenase rutA) Cluster4365 1 1 0 0 1 0 0 pseudoROD_31701(hypothetical protein (pseudogene)) ENC_16380(EamA-like transporter family.) BN373_16451(putative membrane protein) Cluster4366 1 0 0 1 1 0 0 ROD_03561(gamma-glutamylputrescine synthetase) b1297(gamma-Glu-putrescine synthase) BN373_16341(glutamate--putrescine ligase) Cluster4367 1 0 0 1 1 0 0 ROD_03571(gamma-glutamyl-gamma-aminobutyrate hydrolase) b1298(gamma-Glu-GABA hydrolase) BN373_16331(gamma-glutamyl-gamma-aminobutyrate hydrolase) Cluster4368 1 0 0 1 1 0 0 ROD_03581(transcriptional regulator of the polyamine metabolism genes) b1299(DNA-binding transcriptional repressor for the puu divergon) BN373_16321(transcriptional regulator PuuR) Cluster4369 1 0 0 1 1 0 0 ROD_03591(gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase) b1300(gamma-Glu-gamma-aminobutyraldehyde dehydrogenase, NAD(P)H-dependent) BN373_16311(gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase) Cluster4370 1 0 0 1 1 0 0 ROD_03601(gamma-glutamylputrescine oxidoreductase) b1301(gamma-Glu-putrescine oxidase, FAD/NAD(P)-binding) BN373_16301(gamma-glutamylputrescine oxidoreductase) Cluster4371 1 0 0 1 1 0 0 ROD_18421(probable tartrate dehydrogenase/decarboxylase (D-malate dehydrogenase [decarboxylating])) b1800(D-malate oxidase, NAD-dependent; probable tartrate dehydrogenase) BN373_16281(tartrate dehydrogenase/decarboxylase) Cluster4372 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2716(hypothetical protein,phage resistance protein,Predicted signal transduction protein containing sensor and EAL domains,EAL domain) b1168(predicted cyclic-di-GMP phosphodiesterase) BN373_16221(diguanylate phosphodiesterase) Cluster4373 0 0 0 0 1 1 1 BN373_15741(regulator for leucine (or lrp) regulon and high-affinity branched-chain amino acid transport system) t1933(putative transcriptional regulator) SL1344_0938(putative transcriptional regulator) Cluster4374 0 1 0 0 1 1 0 ENC_11760(diguanylate cyclase (GGDEF) domain) BN373_15151(conserved hypothetical protein) t1011(conserved hypothetical protein) Cluster4375 0 0 0 0 1 1 1 BN373_14871(phage tail protein) t4299(putative phage tail protein) SL1344_2670(putative bacteriophage tail protein) Cluster4376 0 0 0 0 1 1 1 BN373_14731(lysis-like protein) t4312(putative regulatory protein) SL1344_2684(putative regulatory protein) Cluster4377 0 0 0 0 1 1 1 BN373_14721(phage lysozyme) t4314(putative lysozyme) SL1344_2686(putative lysozyme) Cluster4378 0 0 0 0 1 1 1 BN373_14711(phage-holin-like protein) t4315(possible secretion protein) SL1344_2687(possible secretion protein) Cluster4379 0 0 0 0 1 1 1 BN373_14621(conserved hypothetical protein) t3411(hypothetical protein) SL1344_2700(predicted bacteriophage protein) Cluster4380 0 1 1 0 1 0 0 ENC_18940(Sugar phosphate permease) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.15(Hexuronate transporter,regulatory protein UhpC,Arabinose efflux permease,D-galactonate transporter,Major Facilitator Superfamily) BN373_14191(putative hexuronate transporter) Cluster4381 0 1 1 0 1 0 0 ENC_18950(Alpha-glucosidases, family 31 of glycosyl hydrolases) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.14(Alpha-xylosidase,putative alpha-glucosidase,Glycosyl hydrolases family 31) BN373_14181(glycosyl hydrolase, family 31) Cluster4382 1 1 0 0 1 0 0 ROD_37151(putative GntR-family transcriptional regulator) ENC_18980(transcriptional regulator, GntR family) BN373_14131(transcriptional regulator, GntR family) Cluster4383 0 1 1 0 1 0 0 ENC_19180(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3182(hypothetical protein) BN373_14091(conserved hypothetical protein) Cluster4384 1 0 0 1 1 0 0 ROD_07971(putative LysR-family transcriptional regulator) b0254(CP4-6 prophage; predicted DNA-binding transcriptional regulator) BN373_13881(transcriptional regulator, LysR family) Cluster4385 1 1 0 0 1 0 0 ROD_36271(universal stress protein g) ENC_41690(Universal stress protein UspA and related nucleotide-binding proteins) BN373_13511(universal stress family protein) Cluster4386 0 1 0 0 2 0 0 ENC_41650(Cation/multidrug efflux pump) BN373_13481(RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family),BN373_27301(RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family) Cluster4387 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2717(hypothetical protein) b1167(predicted protein) BN373_13441(conserved hypothetical protein) Cluster4388 0 0 0 0 1 1 1 BN373_13431(transcriptional regulator, LuxR family) t1143(putative regulatory protein) SL1344_1200(putative regulatory protein) Cluster4389 1 1 0 0 1 0 0 ROD_15391(conserved hypothetical protein) ENC_13750(hypothetical protein) BN373_13391(conserved hypothetical protein) Cluster4390 1 1 0 0 1 0 0 ROD_07151(putative membrane protein) ENC_10400(Predicted membrane protein) BN373_12971(conserved hypothetical protein) Cluster4391 1 1 0 0 1 0 0 ROD_07141(putative membrane protein) ENC_10390(Predicted membrane protein) BN373_12961(conserved hypothetical protein) Cluster4392 1 0 1 0 1 0 0 ROD_05911(putative C-terminal region of transketolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3417(1-deoxy-D-xylulose-5-phosphate synthase,1-deoxy-D-xylulose-5-phosphate synthase,Transketolase, C-terminal subunit,1-deoxy-D-xylulose-5-phosphate synthase,Transketolase, C-terminal domain) BN373_11781(putative transketolase c-terminal subunit) Cluster4393 1 0 1 0 1 0 0 ROD_05901(putative N-terminal region of transketolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3418(Transketolase 2,transketolase,Transketolase, N-terminal subunit,transketolase,Transketolase, thiamine diphosphate binding domain) BN373_11771(transketolase domain protein) Cluster4394 1 0 1 0 1 0 0 ROD_05891(sorbitol operon regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3419(Sor operon activator,transcriptional regulator LsrR,Transcriptional regulator, contains sigma factor-related N-terminal domain,Putative sugar-binding domain) BN373_11761(putative sugar-binding domain protein) Cluster4395 1 0 1 0 1 0 0 pseudoROD_05881(glycerol kinase (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3420(Glycerol kinase,glycerol kinase,glycerol kinase,FGGY family of carbohydrate kinases, N-terminal domain) BN373_11751(putative glycerol kinase) Cluster4396 1 0 1 0 1 0 0 pseudoROD_05861(putative sugar ABC transporter, periplasmic protein precursor (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3421(D-ribose-binding periplasmic protein precursor,D-ribose transporter subunit RbsB,ABC-type sugar transport system, periplasmic component,rhamnose ABC transporter, rhamnose-binding protein,Periplasmic binding proteins and sugar binding domain of LacI family) BN373_11741(sugar ABC transporter, periplasmic sugar-binding protein) Cluster4397 1 0 1 0 1 0 0 ROD_05851(putative lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3422(Predicted periplasmic lipoprotein,Predicted periplasmic lipoprotein (DUF2291)) BN373_11731(putative lipoprotein) Cluster4398 1 0 1 0 1 0 0 ROD_05841(putative sugar ABC transporter, ATP-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3423(Ribose import ATP-binding protein RbsA,xylose transporter ATP-binding subunit,Predicted periplasmic lipoprotein,D-xylose ABC transporter, ATP-binding protein,ABC transporter) BN373_11721(sugar ABC transporter, ATP-binding protein) Cluster4399 1 0 1 0 1 0 0 ROD_05831(putative sugar ABC transporter, permease protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3424(Ribose transport system permease protein rbsC,ribose ABC transporter permease protein,Predicted ABC-type sugar transport system, permease component,urea ABC transporter, permease protein UrtC,Branched-chain amino acid transport system / permease component) BN373_11711(sugar ABC transporter, permease protein) Cluster4400 1 0 1 0 1 0 0 ROD_05821(acetoin reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3425(3-oxoacyl-[acyl-carrier-protein] reductase FabG,3-ketoacyl-(acyl-carrier-protein) reductase,Uncharacterized conserved protein,3-oxoacyl-[acyl-carrier-protein] reductase,short chain dehydrogenase) BN373_11701(oxidoreductase, short chain dehydrogenase/reductase family) Cluster4401 1 0 1 0 1 0 0 ROD_05811(putative short-chain dehydrogenase/reductase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3426(2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase,short chain dehydrogenase,Uncharacterized conserved protein,3-oxoacyl-[acyl-carrier-protein] reductase,short chain dehydrogenase) BN373_11691(oxidoreductase, short chain dehydrogenase/reductase family) Cluster4402 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3761(Inhibitor of vertebrate lysozyme precursor,C-lysozyme inhibitor,Inhibitor of vertebrate lysozyme (Ivy)) b0220(inhibitor of c-type lysozyme, periplasmic) BN373_11651(Inhibitor of vertebrate lysozyme) Cluster4403 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3650(Glycine betaine transporter BetP,choline transport protein BetT,Dephospho-CoA kinase,transporter, betaine/carnitine/choline transporter (BCCT) family,BCCT family transporter) b0314(choline transporter of high affinity) BN373_11641(high-affinity choline transport protein) Cluster4404 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3653(Choline dehydrogenase,choline dehydrogenase,Uncharacterized protein conserved in bacteria,choline dehydrogenase,GMC oxidoreductase) b0311(choline dehydrogenase, a flavoprotein) BN373_11611(choline dehydrogenase) Cluster4405 0 1 1 0 1 0 0 ENC_21620(ABC-type dipeptide/oligopeptide/nickel transport systems, permease components) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4390(Dipeptide transport system permease protein dppB,dipeptide transporter permease DppB,ABC-type antimicrobial peptide transport system, permease component,nickel ABC transporter, permease subunit NikB,Binding-protein-dependent transport system inner membrane component) BN373_11571(ABC transporter, permease protein) Cluster4406 0 1 1 0 1 0 0 ENC_21640(ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4392(Glutathione import ATP-binding protein GsiA,dipeptide transporter ATP-binding subunit,ABC-type oligopeptide transport system, ATPase component,nickel import ATP-binding protein NikD,ABC transporter) BN373_11551(ABC transporter, ATP-binding protein) Cluster4407 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4706(Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase,Predicted periplasmic protein (DUF2233)) b4482(predicted protein, DUF2233 family) BN373_11341(putative lipoprotein) Cluster4408 1 0 0 0 1 0 1 ROD_38571(Putative PTS system transport protein) BN373_11231(putative PTS system transport protein) SL1344_0565(putative protein) Cluster4409 1 0 1 0 1 0 0 ROD_07431(putative tonb dependent receptor) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1730(Ferrichrome receptor FcuA precursor,ferrichrome outer membrane transporter,Outer membrane receptor for monomeric catechols,TonB-dependent siderophore receptor,TonB dependent receptor) BN373_11061(ferrichrome receptor FcuA) Cluster4410 0 0 0 0 1 1 1 BN373_11031(FAD-dependent oxidoreductase) t3050(putative oxidoreductase) SL1344_3102(putative oxidoreductase) Cluster4411 0 0 0 0 1 1 1 BN373_11021(conserved hypothetical protein) t3049(hypothetical protein) SL1344_3101(conserved hypothetical protein) Cluster4412 0 0 0 0 1 1 1 BN373_11011(amino acid permease family protein) t3048(possible amino acid transport protein) SL1344_3100(possible amino acid transport protein) Cluster4413 0 0 0 0 1 1 1 BN373_11001(conserved hypothetical protein) t3047(hypothetical protein) SL1344_3099(hypothetical protein) Cluster4414 0 0 0 0 1 1 1 BN373_10951(monoamine regulon transcriptional regulator) t3046(LysR-family transcriptional regulator) SL1344_3098(LysR-family transcriptional regulator) Cluster4415 0 0 0 0 3 0 0 BN373_10901(conserved hypothetical protein),BN373_11531(conserved hypothetical protein),BN373_18286(hypothetical protein) Cluster4416 0 1 1 0 1 0 0 ENC_10160(beta-fructofuranosidase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1000(Sucrose-6-phosphate hydrolase,sucrose-6-phosphate hydrolase,Glycosyl hydrolases family 32 N-terminal domain) BN373_10761(sucrose-6-phosphate hydrolase) Cluster4417 1 0 0 0 1 0 1 ROD_34531(putative oxidoreductase) BN373_10701(inositol 2-dehydrogenase) SL1344_4363(dehydrogenase) Cluster4418 0 0 2 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1834(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2536(Immunoglobulin I-set domain) BN373_10341(Bacterial surface protein containing Ig-like domains) Cluster4419 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2762(prophage protein NinE) b0548(DLP12 prophage; conserved protein) BN373_10091(prophage protein NinE) Cluster4420 0 1 1 0 1 0 0 ENC_17400(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2769(Uncharacterized protein conserved in bacteria, prophage-related) BN373_09951(predicted antirepressor protein Cro) Cluster4421 0 0 1 0 1 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2773(phage recombination protein Bet,RecT family) BN373_09841(conserved hypothetical protein) t1923(bacteriophage recombination protein) Cluster4422 0 1 0 0 1 1 0 ENC_22720(transcriptional regulator, GntR family) BN373_09261(transcriptional regulator) t3512(putative GntR-family regulatory protein) Cluster4423 0 1 0 1 1 0 0 ENC_23980(Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)) b0261(CP4-6 prophage; S-methylmethionine:homocysteine methyltransferase) BN373_07981(homocysteine S-methyltransferase) Cluster4424 0 1 0 1 1 0 0 ENC_23990(Amino acid transporters) b0260(CP4-6 prophage; predicted S-methylmethionine transporter) BN373_07971(S-methylmethionine permease) Cluster4425 1 1 0 0 1 0 0 ROD_13891(putative periplasmic solute-binding protein precursor,putative periplasmic solute-binding protein of ABC transporter) ENC_13500(amino acid ABC transporter substrate-binding protein, PAAT family (TC 3.A.1.3.-)) BN373_07871(putative amino acid ABC transporter, periplasmic amino acid-binding protein) Cluster4426 1 1 0 0 1 0 0 ROD_13881(putative ATP-binding protein of ABC transporter) ENC_13510(amino acid ABC transporter ATP-binding protein, PAAT family (TC 3.A.1.3.-)) BN373_07861(putative amino acid ABC transporter, ATP-binding protein) Cluster4427 1 1 0 0 1 0 0 pseudoROD_13871(putative ABC transporter, inner membrane protein (fragment)) ENC_13520(amino acid ABC transporter membrane protein 1, PAAT family (TC 3.A.1.3.-)) BN373_07851(putative amino acid ABC transporter, permease protein) Cluster4428 1 1 0 0 1 0 0 ROD_13861(putative ABC transporter, inner membrane protein) ENC_13530(amino acid ABC transporter membrane protein 2, PAAT family (TC 3.A.1.3.-)) BN373_07841(putative amino acid ABC transporter, permease protein) Cluster4429 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3785(hypothetical protein,Uncharacterized distant relative of cell wall-associated hydrolases,Orthopoxvirus protein of unknown function (DUF830)) b0193(predicted lipoprotein) BN373_06981(conserved hypothetical protein) Cluster4430 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.743(Cholera toxin secretion protein epsC,putative type II secretion protein GspC,type II secretion system protein C) pseudob2970(unknown) BN373_06511(pullulanase secretion envelope protein PulC) Cluster4431 0 0 0 0 1 1 1 BN373_06111(putative lipoprotein) t0161(probable secreted protein) SL1344_0155(probable secreted protein) Cluster4432 0 0 0 0 1 1 1 BN373_05431(apo-citrate lyase phosphoribosyl-dephospho-CoA transferase) t0064(citx protein) SL1344_0063(apo-citrate lyase phosphoribosyl-dephospho-CoA transferase) Cluster4433 0 0 0 0 1 1 1 BN373_05201(citrate lyase acyl carrier protein) t0061(citrate lyase acyl carrier protein) SL1344_0060(citrate lyase acyl carrier protein) Cluster4434 0 0 0 0 1 1 1 BN373_05181(citrate:sodium symporter) t0059(citrate-sodium symporter) SL1344_0058(citrate-sodium symporter) Cluster4435 1 1 0 0 1 0 0 ROD_00081(putative transport protein) ENC_45340(Arabinose efflux permease) BN373_04921(transporter, major facilitator family) Cluster4436 1 0 0 0 1 0 1 ROD_48571(putative sugar isomerase) BN373_04351(putative glucosamine-fructose-6-phosphate aminotransferase) SL1344_4471(putative sugar isomerase) Cluster4437 1 0 0 0 1 0 1 ROD_48561(putative sugar isomerase) BN373_04341(SIS domain protein) SL1344_4470(putative sugar isomerase) Cluster4438 1 0 0 0 1 0 1 ROD_48541(PTS transport system, IID component) BN373_04331(PTS system, IID component) SL1344_4469(PTS transport system, IID component) Cluster4439 1 0 0 0 1 0 1 ROD_48521(PTS transport system, IIB component) BN373_04311(PTS system, IIB component) SL1344_4467(PTS transport system, IIB component) Cluster4440 1 0 0 0 1 0 1 ROD_48511(PTS transport system, IIA component) BN373_04301(PTS system, IIA component) SL1344_4466(PTS transport system, IIA component) Cluster4441 1 0 0 0 1 0 1 ROD_48501(putative transcriptional regulatory protein) BN373_04291(sigma-54 dependent transcriptional regulator) SL1344_4465(putative transcriptional regulatory protein) Cluster4442 1 1 0 0 1 0 0 ROD_11961(hypothetical protein) ENC_44760(N-acetylglutamate synthase and related acetyltransferases) BN373_04261(acetyltransferase, GNAT family) Cluster4443 1 0 1 0 1 0 0 ROD_48381(ureidoglycolate dehydrogenase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4422(L-lactate dehydrogenase,putative dehydrogenase,Malate/L-lactate dehydrogenases,ureidoglycolate dehydrogenase,Malate/L-lactate dehydrogenase) BN373_04181(malate/L-lactate dehydrogenase family protein) Cluster4444 0 1 0 0 1 0 1 ENC_44710(5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase) BN373_04121(5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase) SL1344_1041(5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase (ec 1.2.1.-) (chms dehydrogenase)) Cluster4445 0 1 0 0 1 0 1 ENC_44550(NAD-dependent aldehyde dehydrogenases) BN373_03971(aldehyde dehydrogenase (NAD) family protein) SL1344_4450(putative aldehyde dehydrogenase) Cluster4446 1 1 0 0 1 0 0 ROD_48311(putative AraC-family transcriptional regulator) ENC_44540(AraC-type DNA-binding domain-containing proteins) BN373_03951(transcriptional regulator, AraC family) Cluster4447 1 1 0 0 1 0 0 ROD_48301(LysE-family transporter) ENC_44530(Putative threonine efflux protein) BN373_03941(translocator protein, LysE family) Cluster4448 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4060(Benzoyl-CoA reductase subunit C,benzoyl-CoA reductase, bzd-type, N subunit,2-hydroxyglutaryl-CoA dehydratase, D-component) b4335(predicted 2-hydroxyglutaryl-CoA dehydratase) BN373_03901(putative 2-hydroxyglutaryl-CoA dehydratase, D-component) Cluster4449 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4061(2-hydroxyglutaryl-CoA dehydratase component A,Uncharacterized protein conserved in bacteria,putative CoA-substrate-specific enzyme activase,BadF/BadG/BcrA/BcrD ATPase family) b4334(predicted ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase) BN373_03891((R)-2-hydroxyglutaryl-CoA dehydratase activator) Cluster4450 0 1 1 0 1 0 0 ENC_16360(Acetyltransferase (GNAT) family.) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.243(hypothetical protein) BN373_03681(putative GCN5-related N-acetyltransferase) Cluster4451 0 1 0 1 1 0 0 ENC_43830(Beta-xylosidase) b0271(CP4-6 prophage; predicted xylosidase/arabinosidase) BN373_03451(beta-1,4-xylosidase) Cluster4452 1 0 0 0 1 1 0 pseudoROD_33771(conserved hypothetical protein (pseudogene)) BN373_03381(conserved hypothetical protein) t4228(hypothetical protein) Cluster4453 1 0 0 0 1 1 0 ROD_33751(conserved hypothetical protein) BN373_03371(conserved hypothetical protein) t4231(hypothetical protein) Cluster4454 1 0 0 0 1 0 1 pseudoROD_29811(IS256 family transposase (pseudogene)) BN373_03311(putative transposase within prophage) pseudoSL1344_1790(putative transposase(pseudogene)) Cluster4455 0 0 0 0 2 0 1 BN373_03271(conserved hypothetical protein),BN373_p01811(putative transposase-related protein) SL1344_2750(putative transposase) Cluster4456 1 0 0 0 1 1 0 pseudoROD_33611(putative conjugative transfer system protein TraD (fragment)) BN373_03241(conserved hypothetical protein) t4260(hypothetical protein) Cluster4457 1 0 0 0 1 1 0 pseudoROD_33591(putative membrane protein (pseudogene)) BN373_03221(conserved hypothetical protein) t4261(putative membrane protein) Cluster4458 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4115(5-methylcytosine-specific restriction enzyme B,5-methylcytosine-specific restriction enzyme subunit McrB,AAA domain (dynein-related subfamily)) b4346(5-methylcytosine-specific restriction enzyme McrBC, subunit McrB) BN373_03191(5-methylcytosine-specific restriction enzyme with GTPase activity) Cluster4459 0 0 0 0 1 2 0 BN373_03081(protein kinase from phage origin) t4519(protein kinase),t4520(protein kinase) Cluster4460 1 1 0 0 1 0 0 ROD_12471(hypothetical protein) ENC_43540(3-carboxymuconate cyclase) BN373_02521(conserved hypothetical protein) Cluster4461 1 1 0 0 1 0 0 ROD_03701(putative microcin secretion/processing ATP-binding protein) ENC_03160(ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain) BN373_01481(microcin H47 ABC transporter, permease/ATP-binding protein) Cluster4462 0 0 0 0 3 0 0 BN373_01331(IS150 putative transposase),BN373_23831(IS150 putative transposase),BN373_28811(IS150 putative transposase) Cluster4463 0 0 1 1 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2886(Poly-beta-1,6-N-acetyl-D-glucosamine export protein precursor,outer membrane protein PgaA,Flp pilus assembly protein TadD, contains TPR repeats,poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA) b1024(biofilm adhesin polysaccharide PGA export, predicted OM protein) BN373_01281(biofilm PGA synthesis protein PgaA) Cluster4464 0 1 1 0 1 0 0 ENC_05150(Predicted ABC-type sugar transport system, permease component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.443(Ribose transport system permease protein rbsC,L-arabinose transporter permease protein,Predicted ABC-type sugar transport system, permease component,urea ABC transporter, permease protein UrtB,Branched-chain amino acid transport system / permease component) BN373_00991(putative ribose ABC transporter, permease protein) Cluster4465 1 0 1 0 1 0 0 ROD_35231(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3689(Nucleotidyl transferase of unknown function (DUF1814)) BN373_00961(conserved hypothetical protein) Cluster4466 1 0 1 0 1 0 0 ROD_35241(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3690(Protein of unknwon function (DUF2893)) BN373_00951(conserved hypothetical protein) Cluster4467 0 0 0 0 1 1 1 BN373_00801(fimbrial protein) t4634(putative fimbrial protein) SL1344_4522(putative fimbrial protein) Cluster4468 0 0 0 0 1 1 1 BN373_00081(putative shikimate 5-dehydrogenase) t3664(putative shikimate 5-dehydrogenase) SL1344_3826(putative shikimate 5-dehydrogenase) Cluster4469 0 0 0 0 0 2 0 t4287(hypothetical protein),t4288(hypothetical protein) Cluster4470 0 0 0 0 0 2 0 t3425(putative membrane protein),t4313(putative membrane protein) Cluster4471 0 0 0 0 0 2 0 t3090(putative membrane protein),t3091(hypothetical protein) Cluster4472 0 0 0 0 0 2 0 t2862(possible secreted protein),t2863(hypothetical protein) Cluster4473 0 0 0 0 0 2 0 t2661(putative bacteriophage tail protein),t3443(putative phage tail protein) Cluster4474 0 0 0 0 0 2 0 t1107(putative pertussis-like toxin subunit),t1602(hypothetical periplasmic protein) Cluster4475 0 0 0 1 0 1 0 pseudob4486(unknown) t4544(DEAD-box helicase-related protein) Cluster4476 0 0 0 1 0 1 0 pseudob4342(unknown) t4545(conserved hypothetical protein) Cluster4477 0 0 0 0 0 1 1 t4636(putative secreted protein) pseudoSL1344_4523A(putative secreted protein (pseudogene)) Cluster4478 0 0 0 0 0 1 1 t4565(putative membrane protein) pseudoSL1344_4445A(putative membrane protein (pseudogene)) Cluster4479 0 0 0 0 0 1 1 t4548(hypothetical protein) pseudoSL1344_4427A(conserved hypothetical protein (pseudogene)) Cluster4480 0 0 0 0 0 1 1 t1018(hypothetical protein) pseudoSL1344_1789(conserved hypothetical protein (pseudogene)) Cluster4481 0 0 0 0 0 1 1 t1019(hypothetical protein) pseudoSL1344_1788(hypothetical protein) Cluster4482 0 0 0 0 0 1 1 t1692(hypothetical protein) pseudoSL1344_1165(conserved hypothetical protein (pseudogene)) Cluster4483 0 0 0 0 0 0 2 pseudoSL1344_0083A(putative membrane protein (pseudogene)),pseudoSL1344_3673A(putative inner membrane protein (fragment)) Cluster4484 1 0 0 0 0 1 0 pseudoROD_33651(putative Type IV pilus protein (fragment)) t4239(putative exported protein) Cluster4485 1 0 0 0 0 1 0 pseudoROD_33622(putative conjugative transfer system protein TraL (fragment)) t4257(hypothetical protein) Cluster4486 1 0 0 0 0 1 0 pseudoROD_33621(putative conjugative transfer system protein TraW (pseudogene)) t4258(hypothetical protein) Cluster4487 1 0 0 0 0 1 0 pseudoROD_33511(conserved hypothetical protein (pseudogene)) t4265(possible exported protein) Cluster4488 1 0 0 0 0 1 0 pseudoROD_33491(putative conjugative transfer system protein TraB (fragment)) t4268(putative exported protein) Cluster4489 1 0 0 0 0 1 0 pseudoROD_33471(putative conjugative transfer system protein TraU (fragment)) t4273(hypothetical protein) Cluster4490 1 0 0 0 0 1 0 pseudoROD_33451(conserved hypothetical protein (pseudogene)) t4274(hypothetical protein) Cluster4491 1 0 0 0 0 1 0 pseudoROD_33321(putative integrase (pseudogene)) t4357(probable phage integrase) Cluster4492 1 0 0 0 0 1 0 pseudoROD_31961(putative integrase (pseudogene)) t4371(bacteriophage integrase) Cluster4493 1 0 0 0 0 0 1 pseudoROD_31831(IS3 family transposase B (fragment)) pseudoSL1344_0546(transposase (pseudogene)) Cluster4494 1 0 0 1 0 0 0 pseudoROD_26391(IS3 family transposase A (fragment)) pseudob4505(unknown) Cluster4495 0 0 0 2 0 0 0 b4510(DLP12 prophage; predicted lipoprotein),b4528(Rac prophage; predicted lipoprotein) Cluster4496 0 0 0 2 0 0 0 b4504(predicted protein),b4548(predicted protein) Cluster4497 0 0 0 1 0 1 0 b4157(predicted protein) t4398(conserved hypothetical protein) Cluster4498 0 0 0 2 0 0 0 b3594(Predicted lyase containing HEAT-repeat),pseudob4552(unknown) Cluster4499 0 0 0 2 0 0 0 b3488(predicted protein),pseudob4660(unknown) Cluster4500 0 0 0 2 0 0 0 b2634(CP4-57 prophage; predicted DNA-binding transcriptional regulator),pseudob4628(unknown) Cluster4501 0 0 0 2 0 0 0 b1407(predicted PF10971 family periplasmic methylglyoxal resistance protein),pseudob0392(unknown) Cluster4502 0 0 0 2 0 0 0 b1375(cold shock protein, function unknown, Rac prophage),b1544(cold shock protein, function unknown, Qin prophage) Cluster4503 0 0 0 2 0 0 0 b1374(Rac prophage; predicted site-specific recombinase),b1545(Qin prophage; predicted site-specific recombinase) Cluster4504 0 0 0 1 0 1 0 b1085(predicted protein) t1733(conserved hypothetical protein) Cluster4505 0 0 0 2 0 0 0 b0558(DLP12 prophage; predicted protein),b1549(Qin prophage; predicted protein) Cluster4506 0 0 0 2 0 0 0 b0498(predicted protein),b3483(predicted protein) Cluster4507 1 0 0 1 0 0 0 pseudoROD_30031(putative transposase (pseudogene)) b0267(CP4-6 prophage; predicted DNA-binding transcriptional regulator) Cluster4508 0 0 0 2 0 0 0 b0253(CP4-6 prophage; predicted GTP-binding protein),b2632(CP4-57 prophage; predicted GTP-binding protein) Cluster4509 0 0 0 2 0 0 0 b0251(lipoprotein, inner membrane; overproduction stimulates degP expression; CP4-6 prophage),b2636(CP4-57 prophage; predicted protein) Cluster4510 0 0 0 2 0 0 0 b0250(CP4-6 prophage; predicted protein),b2637(CP4-57 prophage; predicted protein) Cluster4511 0 0 0 2 0 0 0 b0245(CP4-6 prophage; toxin of the YkfI-YafW toxin-antitoxin system),b2646(CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system) Cluster4512 0 0 0 0 0 1 1 t4635(putative transcriptional regulator protein) SL1344_4523(putative transcriptional regulator protein) Cluster4513 0 0 0 0 0 1 1 t4572(putative membrane protein) SL1344_4453(putative inner membrane protein) Cluster4514 0 0 0 0 0 1 1 t4571(hypothetical protein) SL1344_4451(hypothetical protein) Cluster4515 0 0 0 0 0 1 1 t4560(probable aspartate racemase) SL1344_4441(probable aspartate racemase) Cluster4516 0 0 0 0 0 1 1 t4559(conserved hypothetical protein) SL1344_4440(conserved hypothetical protein) Cluster4517 0 0 0 0 0 1 1 t4558(hypothetical protein) SL1344_4439(hypothetical protein) Cluster4518 0 0 0 0 0 1 1 t4555(hypothetical protein) SL1344_4436(hypothetical protein) Cluster4519 0 0 0 0 0 1 1 t4554(putative exported protein) SL1344_4435(putative exported protein) Cluster4520 0 0 0 0 0 1 1 t4553(hypothetical protein) SL1344_4434(hypothetical protein) Cluster4521 0 0 0 1 0 0 1 b4268(D-gluconate kinase, thermosensitive) SL1344_4415(thermosensitive gluconokinase (ec 2.7.1.12) (gluconate kinase 1)) Cluster4522 0 0 0 1 0 0 1 b4267(L-idonate 5-dehydrogenase, NAD-binding) SL1344_4414(l-idonate 5-dehydrogenase (ec 1.1.1.264)) Cluster4523 0 0 0 1 0 0 1 b4266(5-keto-D-gluconate-5-reductase) SL1344_4413(gluconate 5-dehydrogenase (ec 1.1.1.69) (5-keto-d-gluconate 5-reductase)) Cluster4524 0 0 0 1 0 0 1 b4265(L-idonate and D-gluconate transporter) SL1344_4412(gnt-ii system l-idonate transporter (l-ido transporter)) Cluster4525 0 0 0 0 0 1 1 t4507(putative exported protein) SL1344_4402(exported protein) Cluster4526 0 0 0 0 0 1 1 t4499(ornithine carbamoyltransferase) SL1344_4395(ornithine carbamoyltransferase) Cluster4527 0 0 0 0 0 1 1 t4492(putative membrane protein) SL1344_4388(putative membrane protein) Cluster4528 0 0 0 0 0 1 1 t4487(hypothetical protein) SL1344_4383(hypothetical protein) Cluster4529 0 0 0 0 0 1 1 t4466(putative sugar transporter) SL1344_4345(putative sugar transporter) Cluster4530 0 0 0 0 0 1 1 t4441(hypothetical protein) SL1344_4323(conserved hypothetical protein) Cluster4531 0 0 0 0 0 1 1 t4403(probable arginine-binding periplasmic protein) SL1344_4288(putative arginine-binding periplasmic protein) Cluster4532 0 0 0 0 0 1 1 t4222(hypothetical protein) SL1344_4252(conserved hypothetical protein) Cluster4533 0 0 0 0 0 1 1 t4221(araC family regulatory protein) SL1344_4251(araC family regulatory protein) Cluster4534 0 0 0 0 0 1 1 t4220(putative GerE family regulatory protein) SL1344_4250(putative GerE family regulatory protein) Cluster4535 0 0 0 0 0 1 1 t4219(hypothetical protein) SL1344_4249(conserved hypothetical protein) Cluster4536 0 0 0 0 0 1 1 t4218(hypothetical protein) SL1344_4248(predicted bacteriophage protein) Cluster4537 0 0 0 0 0 1 1 t4209(hypothetical protein) SL1344_4239(hypothetical protein) Cluster4538 0 0 0 0 0 1 1 t4182(hypothetical protein) SL1344_4212(hypothetical protein) Cluster4539 0 0 0 0 0 1 1 t4168(putative type-1 secretion protein) SL1344_4198(putative type-1 secretion protein) Cluster4540 0 0 0 0 0 1 1 t4165(putative type-I secretion protein) SL1344_4196(putative type-I secretion protein) Cluster4541 0 0 0 0 0 1 1 t4164(putative type-I secretion protein) SL1344_4195(putative type-I secretion protein) Cluster4542 0 0 0 0 0 1 1 t4163(putative integral membrane protein) SL1344_4194(putative integral membrane protein) Cluster4543 0 0 0 0 0 1 1 t4162(putative exported protein) SL1344_4193(type I secretion-related protein) Cluster4544 0 0 0 0 0 1 1 t4118(hypothetical protein) SL1344_4126(hypothetical protein) Cluster4545 0 0 0 0 0 1 1 t3486(hypothetical protein) SL1344_4084(conserved hypothetical protein) Cluster4546 0 0 0 0 0 1 1 t3521(hypothetical protein) SL1344_4046(hypothetical protein) Cluster4547 0 0 0 0 0 1 1 t3538(putative ribulose-phosphate 3-epimerase) SL1344_4029(putative ribulose-phosphate 3-epimerase) Cluster4548 0 0 0 0 0 1 1 t3547(hypothetical protein) SL1344_4020(conserved hypothetical protein) Cluster4549 0 0 0 0 0 1 1 t3550(putative GntR-family regulatory protein) SL1344_4017(putative GntR-family regulatory protein) Cluster4550 0 0 0 0 0 1 1 t3551(hypothetical protein) SL1344_4016(hypothetical protein) Cluster4551 0 0 0 0 0 1 1 t3554(putative membrane protein) SL1344_4014(putative sugar transport protein) Cluster4552 0 0 0 0 0 1 1 t3562(hypothetical protein) SL1344_4006(hypothetical protein) Cluster4553 0 0 0 0 0 1 1 t3568(conserved hypothetical protein) SL1344_4000(conserved hypothetical protein) Cluster4554 0 0 0 0 0 1 1 t3581(putative lipoprotein) SL1344_3987(putative lipoprotein) Cluster4555 0 0 0 0 0 1 1 t3606(hypothetical protein) SL1344_3961(hypothetical protein) Cluster4556 0 0 0 0 0 1 1 t3608(hypothetical protein) SL1344_3960(conserved hypothetical protein) Cluster4557 0 0 0 0 0 1 1 t3609(hypothetical protein) SL1344_3959(hypothetical protein) Cluster4558 0 0 0 0 0 1 1 t3611(hypothetical protein) SL1344_3957(hypothetical protein) Cluster4559 0 0 0 0 0 1 1 t3612(conserved hypothetical protein) SL1344_3956(conserved hypothetical protein) Cluster4560 0 0 0 0 0 1 1 t3317(possible transferase) SL1344_3934(possible transferase) Cluster4561 0 0 0 0 0 1 1 t3353(putative membrane protein) SL1344_3899(putative membrane protein) Cluster4562 0 0 0 0 0 1 1 t3355(conserved hypothetical protein) SL1344_3897(conserved hypothetical protein) Cluster4563 0 0 0 0 0 1 1 t3356(putative membrane protein) SL1344_3896(putative inner membrane protein) Cluster4564 0 0 0 0 0 1 1 t3357(putative membrane protein) SL1344_3895(putative inner membrane protein) Cluster4565 0 0 0 0 0 1 1 t3391(conserved hypothetical protein) SL1344_3867(conserved hypothetical protein) Cluster4566 0 0 0 0 0 1 1 t3656(putative membrane protein) SL1344_3830(putative membrane protein) Cluster4567 0 0 0 0 0 1 1 t3663(conserved hypothetical protein) SL1344_3827(conserved hypothetical protein) Cluster4568 0 0 0 0 0 1 1 t3685(putative LysR-family transcriptioanl regulator) SL1344_3801(putative LysR-family transcriptioanl regulator) Cluster4569 0 0 0 0 0 1 1 t3686(possible racemase) SL1344_3800(possible racemase) Cluster4570 0 0 0 0 0 1 1 t3718(hypothetical protein) SL1344_3767(hypothetical protein) Cluster4571 0 0 0 0 0 1 1 t3746(putative PTS system protein) SL1344_3737(putative PTS system protein) Cluster4572 0 0 0 0 0 1 1 t3747(putative PTS system protein) SL1344_3736(putative PTS system protein) Cluster4573 0 0 0 0 0 1 1 t3750(putative transferase) SL1344_3733(putative transferase) Cluster4574 0 0 0 0 0 1 1 t3751(conserved hypothetical protein) SL1344_3732(conserved hypothetical protein) Cluster4575 0 0 0 0 0 1 1 t3767(hypothetical protein) SL1344_3717(hypothetical protein) Cluster4576 0 0 0 0 0 1 1 t3781(putative beta-lactamase) SL1344_3703(putative beta-lactamase) Cluster4577 0 0 0 0 0 1 1 t3860(putative membrane protein) SL1344_3624(putative membrane protein) Cluster4578 0 0 0 0 0 1 1 t3882(putative lacI-family transcriptional regulator) SL1344_3599(putative lacI-family transcriptional regulator) Cluster4579 0 0 0 0 0 1 1 t3945(methyl-accepting chemotaxis citrate transducer) SL1344_3542(methyl-accepting chemotaxis citrate transducer) Cluster4580 0 0 0 1 0 0 1 b0226(antitoxin of YafQ-DinJ toxin-antitoxin system) SL1344_3484(conserved hypothetical protein (homologue of DnaJ: DNA damage inducible protein)) Cluster4581 0 0 0 1 0 0 1 b0225(translation inhibitor toxin of toxin-antitoxin pair YafQ/DinJ) SL1344_3483(conserved hypothetical protein) Cluster4582 0 0 0 0 0 1 1 t3273(possible GntR-family transcriptional regulator) SL1344_3330(possible GntR-family transcriptional regulator) Cluster4583 0 0 0 0 0 1 1 t3272(possible transcriptional regulator) SL1344_3329(LysR-family transcriptional regulator) Cluster4584 0 0 0 0 0 1 1 t3271(possible membrane transport protein) SL1344_3328(possible membrane transport protein) Cluster4585 0 0 0 0 0 1 1 t3176(phosphoryl transfer protein of PTS system) SL1344_3229(PTS-transport family phosphoryl transfer protein) Cluster4586 0 0 0 0 0 1 1 t3175(sugar phosphotransferase enzyme IIBC component of PTS system) SL1344_3228(PTS system fructose-specific EIIbc component) Cluster4587 0 0 0 0 0 1 1 t3174(possible carbohydrate kinase) SL1344_3227(putative fructose-1-phosphate kinase) Cluster4588 0 0 0 0 0 1 1 t3087(conserved hypothetical protein) SL1344_3141(conserved hypothetical protein) Cluster4589 0 0 0 0 0 1 1 t3080(conserved hypothetical protein) SL1344_3134(conserved hypothetical protein) Cluster4590 0 0 0 0 0 1 1 t3059(hypothetical protein) SL1344_3112(hypothetical protein) Cluster4591 0 0 0 0 0 1 1 t3054(possible hydrolase) SL1344_3107(possible hydrolase) Cluster4592 0 0 0 1 0 0 1 b2920(propionyl-CoA:succinate-CoA transferase) SL1344_3092(putative hydrolase) Cluster4593 0 0 0 0 0 1 1 t3010(probable global regulatory protein) SL1344_3073(probable global regulatory protein) Cluster4594 0 0 0 0 0 1 1 t2970(hypothetical protein) SL1344_3028(hypothetical protein) Cluster4595 0 0 0 0 0 1 1 t2942(outer membrane protein) SL1344_3010(outer membrane protein (associated with virulence)) Cluster4596 0 0 0 0 0 1 1 t2937(hypothetical protein) SL1344_3005(hypothetical protein) Cluster4597 0 0 0 0 0 1 1 t2935(hypothetical protein) SL1344_3003(hypothetical protein) Cluster4598 0 0 0 0 0 1 1 t2894(putative membrane protein) SL1344_2966(putative membrane protein) Cluster4599 0 0 0 0 0 1 1 t2851(hypothetical protein) SL1344_2929(unknown) Cluster4600 0 0 0 0 0 1 1 t2846(possible secreted protein) SL1344_2924(possible secreted protein) Cluster4601 0 0 0 0 0 1 1 t2815(conserved hypothetical protein) SL1344_2893(conserved hypothetical protein) Cluster4602 0 0 0 0 0 1 1 t2814(possible permease) SL1344_2892(possible permease) Cluster4603 0 0 0 0 0 1 1 t2809(hypothetical protein) SL1344_2887(conserved hypothetical protein) Cluster4604 0 0 0 0 0 1 1 t2805(hypothetical protein) SL1344_2885(salmonella pathogenicity island 1 protein) Cluster4605 0 0 0 0 0 1 1 t2802(cell adherance/invasion protein) SL1344_2879(outer membrane lipoprotein) Cluster4606 0 0 0 0 0 1 1 t2801(possible AraC-family regulatory protein) SL1344_2878(AraC-family regulatory protein) Cluster4607 0 0 0 0 0 1 1 t2800(virulence-associated secretory protein) SL1344_2877(type III secretion system secretory apparatus) Cluster4608 0 0 0 0 0 1 1 t2799(cell invasion protein) SL1344_2876(cell invasion protein) Cluster4609 0 0 0 0 0 1 1 t2798(possible virulence-associated secretory protein) SL1344_2875(secretory apparatus of type III secretion system) Cluster4610 0 0 0 0 0 1 1 t2797(virulence-associated secretory protein) SL1344_2874(chaperone protein for type III secretion system effectors) Cluster4611 0 0 0 0 0 1 1 t2796(virulence-associated secretory apparatus ATP synthase) SL1344_2873(secretory apparatus ATP synthase (associated with virulence)) Cluster4612 0 0 0 0 0 1 1 t2795(virulence-associated secretory protein) SL1344_2872(type III secretion system secretory apparatus) Cluster4613 0 0 0 0 0 1 1 t2794(antigen presentation protein SpaN) SL1344_2871(surface presentation of antigens protein (associated with type III secretion and virulence)) Cluster4614 0 0 0 0 0 1 1 t2793(antigen presentation protein SpaO) SL1344_2870(surface presentation of antigens protein (associated with type III secretion and virulence)) Cluster4615 0 0 0 0 0 1 1 t2792(virulence-associated secretory protein) SL1344_2869(type III secretion system secretory apparatus) Cluster4616 0 0 0 0 0 1 1 t2791(virulence-associated secretory protein) SL1344_2868(type III secretion system secretory apparatus) Cluster4617 0 0 0 0 0 1 1 t2790(virulence-associated secretory protein) SL1344_2867(type III secretion system secretory apparatus) Cluster4618 0 0 0 0 0 1 1 t2789(virulence-associated secretory protein) SL1344_2866(type III secretion system secretory apparatus) Cluster4619 0 0 0 0 0 1 1 t2787(pathogenicity island 1 effector protein) SL1344_2864(pathogenicity island 1 effector protein) Cluster4620 0 0 0 0 0 1 1 t2786(pathogenicity island 1 effector protein) SL1344_2863(pathogenicity island 1 effector protein) Cluster4621 0 0 0 0 0 1 1 t2785(pathogenicity island 1 effector protein) SL1344_2862(pathogenicity island 1 effector protein) Cluster4622 0 0 0 0 0 1 1 t2784(pathogenicity island 1 effector protein) SL1344_2861(pathogenicity island 1 effector protein) Cluster4623 0 0 0 0 0 1 1 t2783(probable acyl carrier protein) SL1344_2860(probable acyl carrier protein) Cluster4624 0 0 0 0 0 1 1 t2781(chaperone) SL1344_2859(chaperone (associated with virulence)) Cluster4625 0 0 0 0 0 1 1 t2780(tyrosine phosphatase) SL1344_2858(tyrosine phosphatase (associated with virulence)) Cluster4626 0 0 0 0 0 1 1 t2777(AraC-family transcriptional regulator) SL1344_2855(AraC-family transcriptional regulator) Cluster4627 0 0 0 0 0 1 1 t2776(pathogenicity 1 island effector protein) SL1344_2854(type III secretion apparatus component) Cluster4628 0 0 0 0 0 1 1 t2775(pathogenicity 1 island effector protein) SL1344_2853(type III secretion system apparatus) Cluster4629 0 0 0 0 0 1 1 t2774(pathogenicity 1 island effector protein) SL1344_2852(type III secretion system apparatus) Cluster4630 0 0 0 0 0 1 1 t2773(pathogenicity 1 island effector protein) SL1344_2851(type III secretion system apparatus) Cluster4631 0 0 0 0 0 1 1 t2772(oxygen-regulated invasion protein) SL1344_2850(oxygen-regulated invasion protein) Cluster4632 0 0 0 0 0 1 1 t2770(hypothetical protein found within S. typhi pathogenicity island 1) SL1344_2848(hypothetical protein found within S. typhi pathogenicity island 1) Cluster4633 0 0 0 0 0 1 1 t2769(possible AraC-family transcriptional regulator) SL1344_2847(AraC-family transcriptional regulator) Cluster4634 0 0 0 0 0 1 1 t2768(possible AraC-family transcriptional regulator) SL1344_2846(AraC-family transcriptional regulator) Cluster4635 0 0 0 0 0 1 1 t2746(putative exported protein) SL1344_2824(putative exported protein) Cluster4636 0 0 0 0 0 1 1 t2701(hypothetical protein) SL1344_2789(hypothetical protein) Cluster4637 0 0 0 0 0 1 1 t2676(putative transcriptional regulator) SL1344_2765(putative transcriptional regulator) Cluster4638 0 0 0 0 0 1 1 t4528(hypothetical P4 phage protein) SL1344_2721(hypothetical P4 bacteriophage protein) Cluster4639 0 0 0 0 0 1 1 t4527(hypothetical protein) SL1344_2720(predicted bacteriophage protein) Cluster4640 0 0 0 0 0 1 1 t2650(hypothetical protein) SL1344_2718(probable bacteriophage capsid protein) Cluster4641 0 0 0 0 0 1 1 t4336(phage regulatory protein) SL1344_2707(bacteriophage regulatory protein) Cluster4642 0 0 0 0 0 1 1 t4305(probable phage tail fiber protein) SL1344_2676(probable bacteriophage tail fibre protein) Cluster4643 0 0 0 0 0 1 1 t4303(invasion-associated secreted protein) SL1344_2674(invasion-associated secreted protein) Cluster4644 0 0 0 0 0 1 1 t2635(hypothetical protein) SL1344_2653(conserved hypothetical protein) Cluster4645 0 0 0 0 0 1 1 t1914(putative methyltransferase) SL1344_2588(putative methyltransferase) Cluster4646 0 0 0 0 0 1 1 t1908(putative damage-inducible protein) SL1344_2584(putative damage-inducible protein) Cluster4647 0 0 0 0 0 1 1 t1907(putative bacteriophage protein) SL1344_2583(predicted bacteriophage protein) Cluster4648 0 0 0 0 0 1 1 t0282(putative transcriptional regulator) SL1344_2537(putative transcriptional regulator) Cluster4649 0 0 0 0 0 1 1 t0284(putative oxidoreductase) SL1344_2535(putative oxidoreductase) Cluster4650 0 0 0 0 0 1 1 t0306(anaerobic sulfite reductase subunit C) SL1344_2512(anaerobic sulfite reductase subunit C) Cluster4651 0 0 0 0 0 1 1 t0307(anaerobic sulfite reductase subunit B) SL1344_2511(anaerobic sulfite reductase subunit B) Cluster4652 0 0 0 0 0 1 1 t0308(anaerobic sulfite reductase subunit A) SL1344_2510(anaerobic sulfite reductase subunit A) Cluster4653 0 0 0 0 0 1 1 t0352(hypothetical protein) SL1344_2467(hypothetical protein) Cluster4654 0 0 0 0 0 1 1 t0384(hypothetical protein) SL1344_2438(hypothetical protein) Cluster4655 0 0 0 0 0 1 1 t0405(hypothetical protein) SL1344_2416(conserved hypothetical protein) Cluster4656 0 0 0 0 0 1 1 t0406(putative membrane protein) SL1344_2415(putative membrane protein) Cluster4657 0 0 0 0 0 1 1 t0488(putative lipoprotein) SL1344_2345(putative lipoprotein) Cluster4658 0 0 0 0 0 1 1 t0489(hypothetical protein) SL1344_2344(hypothetical protein) Cluster4659 0 0 0 0 0 1 1 t0503(putative transcriptional regulator) SL1344_2330(putative transcriptional regulator) Cluster4660 0 0 0 0 0 1 1 t0504(putative amino acid decarboxylase) SL1344_2329(putative amino acid decarboxylase) Cluster4661 0 0 0 0 0 1 1 t0505(putative amino acid transporter) SL1344_2328(putative amino acid transporter) Cluster4662 0 0 0 0 0 1 1 t0506(conserved hypothetical protein) SL1344_2327(conserved hypothetical protein) Cluster4663 0 0 0 0 0 1 1 t0507(putative amino acid permease) SL1344_2326(putative amino acid permease) Cluster4664 0 0 0 0 0 1 1 t0535(hypothetical protein) SL1344_2298(hypothetical protein) Cluster4665 0 0 0 0 0 1 1 t0575(hypothetical protein) SL1344_2257(conserved hypothetical protein) Cluster4666 0 0 0 0 0 1 1 t0584(putative transmembrane transport protein) SL1344_2249(putative transmembrane transport protein) Cluster4667 0 0 0 0 0 1 1 t0589(hypothetical protein) SL1344_2244(putative transcriptional regulator) Cluster4668 0 0 0 0 0 1 1 t0591(putative MR-MLE-family protein) SL1344_2242(putative MR-MLE-family protein) Cluster4669 0 0 0 0 0 1 1 t0619(hypothetical protein) SL1344_2221(exported protein) Cluster4670 0 0 0 0 0 1 1 t0620(homolog of virulence protein msgA) SL1344_2220(homolog of virulence protein msgA) Cluster4671 0 0 0 0 0 1 1 t0623(secreted effector protein) SL1344_2217(secreted effector protein) Cluster4672 0 0 0 1 0 0 1 b0551(DLP12 prophage; predicted antitermination protein) SL1344_2215(predicted bacteriophage protein) Cluster4673 0 0 0 0 0 1 1 t0629(putative membrane protein) SL1344_2202(putative membrane protein) Cluster4674 0 0 0 0 0 1 1 t0646(hypothetical protein) SL1344_2186(hypothetical protein) Cluster4675 0 0 0 0 0 1 1 t0647(putative membrane protein) SL1344_2185(putative membrane protein) Cluster4676 0 0 0 0 0 1 1 t0658(putative hydrolase) SL1344_2174(putative hydrolase) Cluster4677 0 0 0 0 0 1 1 t0659(putative L-serine dehydratase) SL1344_2173(putative L-serine dehydratase) Cluster4678 0 0 0 0 0 1 1 t0660(putative DNA-binding protein) SL1344_2172(putative DNA-binding protein) Cluster4679 0 0 0 0 0 1 1 t0699(putative lipoprotein) SL1344_2134(putative lipoprotein) Cluster4680 0 0 0 0 0 1 1 t0717(hypothetical protein) SL1344_2116(hypothetical protein) Cluster4681 0 0 0 0 0 1 1 t0718(putative membrane protein) SL1344_2115(putative membrane protein) Cluster4682 0 0 0 0 0 1 1 t0737(hypothetical protein) SL1344_2111(hypothetical protein) Cluster4683 0 0 0 0 0 1 1 t0738(hypothetical protein) SL1344_2110(hypothetical protein) Cluster4684 0 0 0 0 0 1 1 t0739(hypothetical protein) SL1344_2109(conserved hypothetical protein) Cluster4685 0 0 0 0 0 1 1 t0780(glucose-1-phosphate cytidylyltransferase) SL1344_2069(glucose-1-phosphate cytidylyltransferase) Cluster4686 0 0 0 0 0 1 1 t0781(CDP-glucose 4,6-dehydratase) SL1344_2068(CDP-glucose 4,6-dehydratase) Cluster4687 0 0 0 0 0 1 1 t0782(putative dehydratase RfbH) SL1344_2067(putative dehydratase RfbH) Cluster4688 0 0 0 0 0 1 1 t0783(paratose synthase) SL1344_2066(CDP-abequose synthase) Cluster4689 0 0 0 0 0 1 1 t0785(putative O-antigen transporter) SL1344_2065(putative O-antigen transporter) Cluster4690 0 0 0 0 0 1 1 t0788(putative rhamnosyltransferase) SL1344_2062(putative rhamnosyltransferase) Cluster4691 0 0 0 0 0 1 1 t0790(phosphomannomutase) SL1344_2060(phosphomannomutase) Cluster4692 0 0 0 0 0 1 1 t0791(undecaprenyl-phosphate galactosephosphotransferase) SL1344_2059(undecaprenyl-phosphate galactosephosphotransferase) Cluster4693 0 0 0 0 0 1 1 t0809(thiosulfate reductase precursor) SL1344_2041(thiosulfate reductase precursor) Cluster4694 0 0 0 0 0 1 1 t0810(thiosulfate reductase electron transport protein) SL1344_2040(thiosulfate reductase electron transport protein PhsB) Cluster4695 0 0 0 1 0 0 1 b2357(CPS-53 (KpLE1) prophage; predicted protein) SL1344_1963(predicted bacteriophage protein) Cluster4696 0 0 0 0 0 0 2 SL1344_1954(predicted bacteriophage protein),SL1344_1961(predicted bacteriophage protein) Cluster4697 0 0 0 0 0 0 2 SL1344_1928(putative bacteriophage protein),SL1344_2113(predicted bacteriophage protein) Cluster4698 0 0 0 0 0 1 1 t0879(hypothetical protein) SL1344_1927(conserved hypothetical protein) Cluster4699 0 0 0 0 0 1 1 t0910(putative exported protein) SL1344_1896(putative exported protein) Cluster4700 0 0 0 0 0 1 1 t0936(hypothetical protein) SL1344_1874(putative membrane protein) Cluster4701 0 0 0 0 0 1 1 t0937(putative exported protein) SL1344_1873(putative exported protein) Cluster4702 0 0 0 0 0 1 1 t0938(hypothetical protein) SL1344_1872(Conserved hypothetical protein) Cluster4703 0 0 0 0 0 0 2 SL1344_1799(bacteriophage encoded pagK (phoPQ-activated protein)),SL1344_2549(Endodeoxyribonuclease) Cluster4704 0 0 0 0 0 1 1 t1014(putative membrane protein) SL1344_1795(putative membrane protein) Cluster4705 0 0 0 0 0 1 1 t1015(hypothetical protein) SL1344_1794(putative inner membrane protein) Cluster4706 0 0 0 0 0 1 1 t1021(hypothetical protein) SL1344_1786(hypothetical protein) Cluster4707 0 0 0 0 0 1 1 t1024(hypothetical protein) SL1344_1783(hypothetical protein) Cluster4708 0 0 0 0 0 1 1 t1067(hypothetical protein) SL1344_1738(hypothetical protein) Cluster4709 0 0 0 0 0 1 1 t1091(hypothetical protein) SL1344_1713(conserved hypothetical protein) Cluster4710 0 0 0 0 0 1 1 t1669(putative secreted protein) SL1344_1688(putative secreted protein) Cluster4711 0 0 0 0 0 1 1 t1640(conserved hypothetical protein) SL1344_1659(conserved hypothetical protein) Cluster4712 0 0 0 0 0 1 1 t1612(hypothetical protein) SL1344_1628(hypothetical protein) Cluster4713 0 0 0 0 0 1 1 t1611(conserved hypothetical protein) SL1344_1627(conserved hypothetical protein) Cluster4714 0 0 0 0 0 1 1 t1577(putative lipoprotein) SL1344_1603(putative lipoprotein) Cluster4715 0 0 0 0 0 1 1 t1576(hypothetical protein) SL1344_1602(hypothetical protein) Cluster4716 0 0 0 0 0 1 1 t1574(putative lipoprotein) SL1344_1600(putative lipoprotein) Cluster4717 0 0 0 0 0 1 1 t1573(invasin-like protein) SL1344_1599(invasin-like protein) Cluster4718 0 0 0 0 0 1 1 t1572(putative exported protein) SL1344_1598(putative exported protein) Cluster4719 0 0 0 0 0 1 1 t1571(putative thiol peroxidase) SL1344_1597(putative thiol peroxidase) Cluster4720 0 0 0 0 0 1 1 t1561(putative chemo-receptor protein) SL1344_1588(putative chemo-receptor protein) Cluster4721 0 0 0 0 0 1 1 t1540(putative membrane protein) SL1344_1567(putative membrane protein) Cluster4722 0 0 0 0 0 1 1 t1539(putative amino acid ABC transporter) SL1344_1566(putative amino acid ABC transporter) Cluster4723 0 0 0 0 0 1 1 t1538(ABC transporter ATP-binding subunit) SL1344_1565(ABC transporter ATP-binding subunit) Cluster4724 0 0 0 0 0 1 1 t1537(putative ABC amino acid transporter permease) SL1344_1564(putative ABC amino acid transporter permease) Cluster4725 0 0 0 0 0 1 1 t1536(putative periplasmic amino acid-binding protein) SL1344_1563(putative periplasmic amino acid-binding protein) Cluster4726 0 0 0 0 0 1 1 t1530(putative exported protein) SL1344_1551(putative exported protein) Cluster4727 0 0 0 0 0 1 1 t1529(putative glycolate oxidase) SL1344_1550(putative L-lactate oxidase) Cluster4728 0 0 0 0 0 1 1 t1528(aminoglycoside 6'-N-acetyltransferase) SL1344_1549(aminoglycoside 6'-N-acetyltransferase) Cluster4729 0 0 0 0 0 1 1 t1511(putative virulence effector protein) SL1344_1532(putative virulence effector protein) Cluster4730 0 0 0 0 0 1 1 t1510(putative membrane protein) SL1344_1531(putative membrane protein) Cluster4731 0 0 0 0 0 1 1 t1509(conserved hypothetical protein) SL1344_1530A(conserved hypothetical protein) Cluster4732 0 0 0 0 0 1 1 t1493(hypothetical protein) SL1344_1514(hypothetical protein) Cluster4733 0 0 0 0 0 1 1 t1468(hypothetical protein) SL1344_1484(conserved hypothetical protein) Cluster4734 0 0 0 0 0 1 1 t1467(putative isomerase) SL1344_1477(putative isomerase) Cluster4735 0 0 0 0 0 1 1 t1463(hypothetical protein) SL1344_1473(PhoPQ-activated protein) Cluster4736 0 0 0 0 0 1 1 t1461(putative alcohol dehydrogenase) SL1344_1471(putative alcohol dehydrogenase) Cluster4737 0 0 0 0 0 1 1 t1460(putative regulatory protein) SL1344_1470(putative regulatory protein) Cluster4738 0 0 0 0 0 1 1 t1459(putative secreted hydrolase) SL1344_1469(putative secreted hydrolase) Cluster4739 0 0 0 0 0 1 1 t1456(Ni/Fe-hydrogenase 1 b-type cytochrome subunit HyaC2) SL1344_1466(Ni/Fe-hydrogenase 1 b-type cytochrome subunit HyaC2) Cluster4740 0 0 0 0 0 1 1 t1455(hydrogenase 1 maturation protease) SL1344_1465(hydrogenase 1 maturation protease) Cluster4741 0 0 0 0 0 1 1 t1454(hydrogenase isoenzymes formation protein) SL1344_1464(hydrogenase isoenzymes formation protein) Cluster4742 0 0 0 0 0 1 1 t1453(hydrogenase-1 operon protein HyaE2) SL1344_1463(hydrogenase-1 operon protein HyaE2) Cluster4743 0 0 0 0 0 1 1 t1452(hydrogenase-1 operon protein HyaF2) SL1344_1462(hydrogenase-1 operon protein HyaF2) Cluster4744 0 0 0 0 0 1 1 t1451(putative ATP/GTP-binding protein) SL1344_1461(putative ATP/GTP-binding protein) Cluster4745 0 0 0 0 0 1 1 t1449(putative exported protein) SL1344_1458(putative exported protein) Cluster4746 0 0 0 0 0 1 1 t1288(putative type III secretion protein) SL1344_1354(putative type III secretion protein) Cluster4747 0 0 0 0 0 1 1 t1286(putative type III secretion protein) SL1344_1352(putative type III secretion protein) Cluster4748 0 0 0 0 0 1 1 t1285(putative type III secretion protein) SL1344_1351(putative type III secretion protein) Cluster4749 0 0 0 0 0 1 1 t1284(putative type III secretion protein) SL1344_1350(putative type III secretion protein) Cluster4750 0 0 0 0 0 1 1 t1281(putative pathogenicity island protein) SL1344_1347(putative pathogenicity island protein) Cluster4751 0 0 0 0 0 1 1 t1279(putative pathogenicity island protein) SL1344_1345(putative pathogenicity island protein) Cluster4752 0 0 0 0 0 1 1 t1278(putative pathogenicity island protein) SL1344_1344(putative pathogenicity island protein) Cluster4753 0 0 0 0 0 1 1 t1276(putative pathogenicity island protein) SL1344_1342(putative pathogenicity island protein) Cluster4754 0 0 0 0 0 1 1 t1275(putative pathogenicity island protein) SL1344_1341(Type three secretion system apparatus) Cluster4755 0 0 0 0 0 1 1 t1273(putative pathogenicity island effector protein) SL1344_1339(putative pathogenicity island effector protein) Cluster4756 0 0 0 0 0 1 1 t1272(putative pathogenicity island effector protein) SL1344_1338(putative pathogenicity island effector protein) Cluster4757 0 0 0 0 0 1 1 t1271(putative pathogenicity island protein) SL1344_1337(Type III secretion system chaperone protein) Cluster4758 0 0 0 0 0 1 1 t1270(putative pathogenicity island effector protein) SL1344_1336(putative pathogenicity island protein) Cluster4759 0 0 0 0 0 1 1 t1269(putative pathogenicity island effector protein) SL1344_1335(putative pathogenicity island effector protein) Cluster4760 0 0 0 0 0 1 1 t1268(putative pathogenicity island effector protein) SL1344_1334(putative pathogenicity island effector protein) Cluster4761 0 0 0 0 0 1 1 t1265(putative pathogenicity island protein) SL1344_1331(T3SS chaperone) Cluster4762 0 0 0 0 0 1 1 t1211(hypothetical protein) SL1344_1330A(conserved hypothetical protein) Cluster4763 0 0 0 0 0 1 1 t1264(putative secretion system protein) SL1344_1330(type three secretion system protein) Cluster4764 0 0 0 0 0 1 1 t1261(putative pathogenicity island secreted effector protein) SL1344_1327(putative pathogenicity island 2 secreted effector protein) Cluster4765 0 0 0 0 0 1 1 t1260(putative two-component sensor kinase) SL1344_1326(putative two-component sensor kinase) Cluster4766 0 0 0 0 0 1 1 t1259(putative two-component response regulator) SL1344_1325(putative two-component response regulator) Cluster4767 0 0 0 0 0 1 1 t1254(hypothetical protein) SL1344_1320(putative histidine kinase, two component regulatory protein) Cluster4768 0 0 0 0 0 1 1 t1253(tetrathionate reductase subunit B) SL1344_1319(tetrathionate reductase subunit B) Cluster4769 0 0 0 0 0 1 1 t1252(tetrathionate reductase subunit C) SL1344_1318(tetrathionate reductase subunit C (membrane protein)) Cluster4770 0 0 0 0 0 1 1 t1251(tetrathionate reductase subunit A) SL1344_1317(tetrathionate reductase subunit A) Cluster4771 0 0 0 0 0 1 1 t1249(Orf 245 protein) SL1344_1315(hypothetical protein) Cluster4772 0 0 0 0 0 1 1 t1247(putative amino acid permease) SL1344_1313(putative amino acid permease) Cluster4773 0 0 0 0 0 1 1 t1244(major outer membrane lipoprotein) SL1344_1310(major outer membrane lipoprotein) Cluster4774 0 0 0 0 0 1 1 t1236(putative transporter) SL1344_1302(putative transporter) Cluster4775 0 0 0 0 0 1 1 t1212(O-antigen polymerase) SL1344_1266(O-antigen polymerase) Cluster4776 0 0 0 0 0 1 1 t1209(putative membrane protein) SL1344_1264(putative membrane protein) Cluster4777 0 0 0 0 0 1 1 t1152(hypothetical protein) SL1344_1209(conserved hypothetical protein) Cluster4778 0 0 0 0 0 1 1 t1147(putative chorismate mutase) SL1344_1204(chorismate mutase) Cluster4779 0 0 0 0 0 1 1 t1146(hypothetical protein) SL1344_1203(hypothetical protein) Cluster4780 0 0 0 0 0 1 1 t1144(putative transcriptional regulator) SL1344_1201(putative transcriptional regulator) Cluster4781 0 0 0 0 0 1 1 t1132(putative lipoprotein) SL1344_1190(putative lipoprotein) Cluster4782 0 0 0 0 0 1 1 t1130(hypothetical protein) SL1344_1188(hypothetical protein) Cluster4783 0 0 0 0 0 1 1 t1127(hypothetical protein) SL1344_1186(hypothetical protein) Cluster4784 0 0 0 0 0 1 1 t1116(putative outer membrane virulence protein) SL1344_1183(putative outer membrane virulence protein (PagD)) Cluster4785 0 0 0 0 0 1 1 t1114(putative lipoprotein) SL1344_1181(putative lipoprotein) Cluster4786 0 0 0 0 0 1 1 t1106(putative bacteriophage protein) SL1344_1177(predicted bacteriophage protein) Cluster4787 0 0 0 0 0 1 1 t1684(putative secreted protein) SL1344_1174(putative secreted protein) Cluster4788 0 0 0 0 0 1 1 t1696(putative virulence determinant) SL1344_1161(putative virulence determinant) Cluster4789 0 0 0 0 0 1 1 t1793(putative membrane transporter) SL1344_1066(putative sodium/glucose cotransporter) Cluster4790 0 0 0 0 0 1 1 t1810(hypothetical protein) SL1344_1048(hypothetical protein) Cluster4791 0 0 0 0 0 1 1 t1825(putative secreted peptidase) SL1344_1033(putative secreted peptidase) Cluster4792 0 0 0 0 0 1 1 t1826(hypothetical protein) SL1344_1032(hypothetical protein) Cluster4793 0 0 0 0 0 1 1 t1828(cell invasion protein) SL1344_1030(cell invasion protein) Cluster4794 0 0 0 0 0 1 1 t1829(cell invasion protein) SL1344_1029(cell invasion protein) Cluster4795 0 0 0 0 0 1 1 t1830(conserved hypothetical protein) SL1344_1027(conserved hypothetical protein) Cluster4796 0 0 0 0 0 1 1 t1831(conserved hypothetical protein) SL1344_1026(conserved hypothetical protein) Cluster4797 0 0 0 0 0 1 1 t1864(conserved hypothetical protein) SL1344_0996(bacteriophage encoded virulence protein) Cluster4798 0 0 0 0 0 0 2 SL1344_0968(predicted bacteriophage protein),SL1344_1801(predicted bacteriophage protein) Cluster4799 0 0 0 0 0 0 2 SL1344_0965(putative bacteriophage encoded virulence protein),SL1344_2577(putative bacteriophage encoded virulence protein) Cluster4800 0 0 0 0 0 1 1 t1902(putative lipoprotein) SL1344_0964(putative bacteriophage lipoprotein) Cluster4801 0 0 0 0 0 1 1 t1903(putative bacteriophage protein) SL1344_0963(predicted bacteriophage protein) Cluster4802 0 0 0 0 0 1 1 t1915(conserved hypothetical bacteriophage protein) SL1344_0955(predicted bacteriophage protein) Cluster4803 0 0 0 0 0 1 1 t1916(putative DNA-binding protein) SL1344_0954(predicted bacteriophage protein) Cluster4804 0 0 0 0 0 1 1 t1919(putative DNA-binding protein) SL1344_0951(transcriptional activator-regulatory protein) Cluster4805 0 0 0 0 0 0 2 SL1344_0949(predicted bacteriophage protein),pseudoSL1344_2596(predicted bacteriophage protein (fragment)) Cluster4806 0 0 0 1 0 0 1 b4526(Rac prophage; conserved protein) SL1344_0948(predicted bacteriophage protein) Cluster4807 0 0 0 0 0 0 2 SL1344_0945(predicted bacteriophage protein),SL1344_2597A(predicted bacteriophage protein) Cluster4808 0 0 0 0 0 1 1 t1931(putative ion:amino acid symporter) SL1344_0940(putative ion:amino acid symporter) Cluster4809 0 0 0 0 0 1 1 t1983(conserved hypothetical protein) SL1344_0888(conserved hypothetical protein) Cluster4810 0 0 0 0 0 1 1 t2079(putative membrane protein) SL1344_0784(putative membrane protein) Cluster4811 0 0 0 0 0 1 1 t2110(putative membrane protein) SL1344_0754(putative membrane protein) Cluster4812 0 0 0 0 0 0 2 SL1344_0746(conserved hypothetical protein),SL1344_3322(conserved hypothetical protein) Cluster4813 0 0 0 0 0 1 1 t2145(hypothetical protein) SL1344_0713(putative exported protein) Cluster4814 0 0 0 0 0 1 1 t2149(hypothetical protein) SL1344_0709(conserved hypothetical cytoplasmic protein) Cluster4815 0 0 0 0 0 1 1 t2151(conserved hypothetical protein) SL1344_0707(putative glycosyltransferase, cell wall biogenesis) Cluster4816 0 0 0 0 0 1 1 t2159(putative membrane protein) SL1344_0698(putative protein) Cluster4817 0 0 0 0 0 1 1 t2161(hypothetical protein) SL1344_0696(putative protein) Cluster4818 0 0 0 0 0 1 1 t2176(possible 5-nitroimidazole antibiotic resistance) SL1344_0681(possible 5-nitroimidazole antibiotic resistance) Cluster4819 0 0 0 1 0 0 1 b0645(predicted protein) SL1344_0643(conserved hypothetical protein) Cluster4820 0 0 0 0 0 1 1 t2216(probable permease) SL1344_0639(probable permease) Cluster4821 0 0 0 0 0 1 1 t2217(putative hydrolase C-terminus) SL1344_0638(putative hydrolase C-terminus) Cluster4822 0 0 0 0 0 1 1 t2218(putative hydrolase N-terminus) SL1344_0637(putative hydrolase N-terminus) Cluster4823 0 0 0 0 0 1 1 t2254(molybdopterin-containing oxidoreductase membrane anchor subunit) SL1344_0601(molybdopterin-containing oxidoreductase membrane anchor subunit) Cluster4824 0 0 0 0 0 1 1 t2255(molybdopterin-containing oxidoreductase iron-sulfur subunit) SL1344_0600(molybdopterin-containing oxidoreductase iron-sulfur subunit) Cluster4825 0 0 0 0 0 1 1 t2256(molybdopterin-containing oxidoreductase catalytic subunit) SL1344_0599(molybdopterin-containing oxidoreductase catalytic subunit) Cluster4826 0 0 0 0 0 1 1 t2257(conserved hypothetical protein) SL1344_0598(conserved hypothetical protein) Cluster4827 0 0 0 0 0 1 1 t2291(outer membrane esterase) SL1344_0558(outer membrane esterase) Cluster4828 0 0 0 0 0 1 1 t2304(putative membrane protein) SL1344_0547(putative membrane protein) Cluster4829 0 0 0 0 0 1 1 t2311(fimbriae w protein) SL1344_0545(fimbriae w protein) Cluster4830 0 0 0 0 0 1 1 t2312(hypothetical protein) SL1344_0544(hypothetical protein) Cluster4831 0 0 0 0 0 1 1 t2313(fimbriae Y protein) SL1344_0543(fimbriae Y protein) Cluster4832 0 0 0 0 0 1 1 t2319(hypothetical protein) SL1344_0537(major pilin protein) Cluster4833 0 0 0 0 0 1 1 t2348(ABC transporter integral membrane protein) SL1344_0505(ABC transporter integral membrane protein) Cluster4834 0 0 0 0 0 1 1 t2422(conserved hypothetical protein) SL1344_0432(conserved hypothetical protein) Cluster4835 0 0 0 0 0 1 1 t2425(conserved hypothetical protein) SL1344_0431(putative exported protein) Cluster4836 0 0 0 0 0 1 1 t2502(hypothetical protein) SL1344_0357(hypothetical protein) Cluster4837 0 0 0 0 0 1 1 t2505(hypothetical protein) SL1344_0354(hypothetical protein) Cluster4838 0 0 0 0 0 1 1 t0871(hypothetical protein) SL1344_0353(type III restriction-modification system enzyme (StyLTI) (ec 3.1.21.5)) Cluster4839 0 0 0 0 0 1 1 t2507(Type III restriction-modification system StyLTI enzyme mod) SL1344_0352(type III restriction-modification system enzyme (StyLTI) modification methylase) Cluster4840 0 0 0 0 0 1 1 t2513(probable secreted protein) SL1344_0343(probable secreted protein) Cluster4841 0 0 0 0 0 1 1 t2525(fimbrial chaperone protein) SL1344_0331(fimbrial chaperone protein) Cluster4842 0 0 0 0 0 1 1 t2526(probable secreted protein) SL1344_0330(probable secreted protein) Cluster4843 0 0 0 0 0 1 1 t2544(possible outer membrane adhesin) SL1344_0302(possible outer membrane adhesin) Cluster4844 0 0 0 0 0 1 1 t2553(hypothetical protein) SL1344_0301(conserved hypothetical protein (SPI-6 associated)) Cluster4845 0 0 0 0 0 1 1 t2554(LysR-family transcriptional regulator SinR) SL1344_0300(LysR-family transcriptional regulator (SPI-6 associated)) Cluster4846 0 0 0 0 0 1 1 t2556(conserved hypothetical protein) SL1344_0299(conserved hypothetical protein) Cluster4847 0 0 0 0 0 1 1 t2561(probable lipoprotein) SL1344_0295(salmonella atypical fimbria lipoprotein) Cluster4848 0 0 0 0 0 1 1 t2570(hypothetical protein) SL1344_0285(conserved hypothetical protein (SPI-6 associated)) Cluster4849 0 0 0 0 0 1 1 t2573(hypothetical protein) SL1344_0283(conserved hypothetical protein (SPI-6 associated)) Cluster4850 0 0 0 0 0 1 1 t2574(probable secreted protein) SL1344_0282(probable secreted protein) Cluster4851 0 0 0 0 0 1 1 t2577(hypothetical protein) SL1344_0281(conserved hypothetical protein (SPI-6 associated)) Cluster4852 0 0 0 0 0 1 1 t2580(putative membrane protein) SL1344_0278(putative membrane protein, virulence associated protein) Cluster4853 0 0 0 0 0 1 1 t2585(hypothetical protein) SL1344_0270(conserved hypothetical protein (SPI-6 associated)) Cluster4854 0 0 0 0 0 1 1 t2593(hypothetical protein) SL1344_0265(conserved hypothetical protein (SPI-6 associated)) Cluster4855 0 0 0 0 0 1 1 t0118(leu operon leader peptide) SL1344_0114(leu operon leader peptide) Cluster4856 0 0 0 0 0 1 1 t0082(probable secreted protein) SL1344_0082(probable secreted protein) Cluster4857 0 0 0 0 0 1 1 t0052(hypothetical protein) SL1344_0051(conserved hypothetical protein) Cluster4858 0 0 0 0 0 1 1 t0033(putative transcriptional regulator) SL1344_0032(putative membrane protein) Cluster4859 0 0 0 0 0 1 1 t0032(putative transcriptional regulator (lysR family)) SL1344_0031(putative transcriptional regulator (lysR family)) Cluster4860 0 0 0 0 0 1 1 t0031(putative membrane protein) SL1344_0030(putative membrane protein) Cluster4861 0 0 0 0 0 1 1 t0030(putative membrane protein) SL1344_0029(putative membrane protein) Cluster4862 1 0 0 0 0 1 0 ROD_49601(conserved hypothetical protein) t4364(transcriptional regulatory protein) Cluster4863 1 0 0 0 0 1 0 ROD_49461(putative integrase) t2953(hypothetical protein) Cluster4864 1 0 0 0 0 1 0 ROD_48321(putative transposase) t4569(putative membrane protein) Cluster4865 1 0 0 0 0 1 0 ROD_46541(putative Type IV pilus biogenesis protein) t4246(putative membrane protein) Cluster4866 1 0 0 0 0 1 0 ROD_46531(putative Type IV pilus biogenesis protein CfcH) t4245(nucleotide-binding protein) Cluster4867 1 0 0 0 0 0 1 ROD_43731(Phage/plasmid maintenance protein) SL1344_3525(prevent host death protein) Cluster4868 1 0 0 0 0 0 1 ROD_42971(anaerobic C4 dicarboxylate membrane transport protein) SL1344_3564(anaerobic C4 dicarboxylate membrane transport protein) Cluster4869 1 0 0 0 0 0 1 ROD_42101(probable glucarate transporter) SL1344_3663(probable glucarate transporter) Cluster4870 2 0 0 0 0 0 0 ROD_41471(conserved hypothetical protein),ROD_41481(conserved hypothetical protein) Cluster4871 1 0 0 0 0 1 0 ROD_39721(putative glycerate kinase) t0367(conserved hypothetical protein) Cluster4872 1 0 0 0 0 1 0 ROD_39711(putative permease) t0366(putative permease) Cluster4873 1 0 0 0 0 0 1 ROD_38761(putative adhesin autotransporter) SL1344_3723(putative autotransported protein (MisL)) Cluster4874 1 0 0 0 0 0 1 ROD_38081(conserved hypothetical protein) SL1344_2881(salmonella pathogenicity island 1 protein) Cluster4875 2 0 0 0 0 0 0 ROD_36871(putative prophage DNA binding protein),ROD_47031(putative prophage DNA binding protein) Cluster4876 2 0 0 0 0 0 0 ROD_35351(hypothetical protein),ROD_35361(hypothetical protein) Cluster4877 1 0 0 0 0 0 1 ROD_34921(anaerobic dimethyl sulfoxide reductase chain A) SL1344_4243(anaerobic dimethyl sulfoxide reductase chain A) Cluster4878 1 0 0 0 0 1 0 ROD_34061(putative DNA methyltransferase) t4342(Putative methyltransferase) Cluster4879 1 0 0 0 0 1 0 ROD_33871(conserved hypothetical protein) t4547(hypothetical protein) Cluster4880 1 0 0 0 0 1 0 ROD_33801(putative partitioning protein A) t4226(hypothetical protein) Cluster4881 1 0 0 0 0 1 0 ROD_33741(conserved hypothetical protein) t4232(hypothetical protein) Cluster4882 1 0 0 0 0 1 0 ROD_33691(conserved hypothetical protein) t4233(hypothetical protein) Cluster4883 1 0 0 0 0 1 0 ROD_33661(conserved hypothetical protein) t4235(hypothetical protein) Cluster4884 1 0 0 0 0 1 0 ROD_33641(putative exported protein) t4255(putative membrane protein) Cluster4885 1 0 0 0 0 1 0 ROD_33631(putative conjugative transfer system protein TraG) t4256(putative exported protein) Cluster4886 1 0 0 0 0 1 0 ROD_33551(conserved hypothetical protein) t4262(hypothetical protein) Cluster4887 1 0 0 0 0 1 0 ROD_33531(putative exported protein) t4264(putative membrane protein) Cluster4888 1 0 0 0 0 1 0 ROD_33501(putative exported protein) t4266(hypothetical protein) Cluster4889 1 0 0 0 0 1 0 ROD_33431(putative conjugative transfer system protein TraG (fragment)) t4276(putative membrane protein) Cluster4890 1 0 0 0 0 1 0 ROD_33361(hypothetical protein) t4284(hypothetical protein) Cluster4891 1 0 0 0 0 1 0 ROD_33331(conserved hypothetical protein) t4356(hypothetical protein) Cluster4892 1 0 0 0 0 0 1 ROD_29381(putative fimbrial usher protein) SL1344_0333(outer membrane fimbrial usher protein) Cluster4893 1 0 0 0 0 0 1 ROD_26381(IS3 family transposase B) SL1344_0886(putative integrase protein) Cluster4894 1 0 0 0 0 0 1 ROD_26041(hypothetical prophage protein) SL1344_4131(hypothetical protein) Cluster4895 1 0 0 0 0 0 1 ROD_25901(putative phage tail sheath protein) SL1344_1941(bacteriophage tail sheath protein) Cluster4896 1 0 0 0 0 0 1 ROD_25891(hypothetical prophage protein) SL1344_1940(bacteriophage tail tube protein) Cluster4897 1 0 0 0 0 0 1 ROD_25851(putative phage DNA circularisation protein) SL1344_1937(predicted bacteriophage protein) Cluster4898 1 0 0 0 0 0 1 ROD_25841(hypothetical prophage protein) SL1344_1936(bacteriophage tail protein) Cluster4899 1 0 0 0 0 0 1 ROD_25831(putative phage baseplate assembly protein) SL1344_1935(putative bacteriophage baseplate protein) Cluster4900 2 0 0 0 0 0 0 ROD_23801(putative exported protein),ROD_23811(putative exported protein) Cluster4901 1 0 0 1 0 0 0 ROD_23651(putative membrane protein) b0702(predicted membrane protein) Cluster4902 2 0 0 0 0 0 0 ROD_23601(putative membrane protein),ROD_40731(putative membrane protein) Cluster4903 2 0 0 0 0 0 0 ROD_23231(conserved hypothetical protein),ROD_25771(hypothetical prophage protein) Cluster4904 1 0 0 0 0 1 0 ROD_22121(putative exported protein) t0736(putative exported protein) Cluster4905 1 0 0 1 0 0 0 ROD_21721(putative O-antigen transporter) b2037(predicted polisoprenol-linked O-antigen transporter) Cluster4906 1 0 0 1 0 0 0 ROD_21521(putative membrane protein) b2013(inner membrane protein, UPF0394 family) Cluster4907 1 0 0 1 0 0 0 ROD_21511(conserved hypothetical protein) b2012(conserved protein) Cluster4908 1 0 0 1 0 0 0 ROD_20991(C4-dicarboxylate transporter) b3227(predicted transporter) Cluster4909 2 0 0 0 0 0 0 ROD_20751(conserved hypothetical protein),pseudoROD_28261(hypothetical protein (fragment)) Cluster4910 1 0 0 0 0 1 0 ROD_20701(hypothetical protein) t4366(hypothetical protein) Cluster4911 1 0 0 0 0 1 0 ROD_20621(conserved hypothetical protein) t0869(hypothetical protein) Cluster4912 1 0 0 0 0 1 0 ROD_20441(integrase) t1986(probable integrase remnant) Cluster4913 2 0 0 0 0 0 0 ROD_20041(putative prophage membrane protein),ROD_36961(putative prophage membrane protein) Cluster4914 2 0 0 0 0 0 0 ROD_19931(hypothetical prophage protein),ROD_36851(hypothetical prophage protein) Cluster4915 2 0 0 0 0 0 0 ROD_19871(putative phage tail protein),ROD_36541(putative phage tail protein) Cluster4916 2 0 0 0 0 0 0 ROD_19792(putative prophage DNA modification regulator),ROD_47451(prophage regulator of DNA modification protein Mom) Cluster4917 1 0 0 0 0 0 1 ROD_19781(flagellin lysine-N-methylase) SL1344_1887(lysine-N-methylase (ec 2.1.1.-) (lysine N-methyltransferase)) Cluster4918 1 0 0 1 0 0 0 ROD_16351(putative CDP-alcohol phosphatidyltransferase) b1408(inner membrane protein) Cluster4919 1 0 0 1 0 0 0 ROD_16341(putative phosphatidate cytidylyltransferase) b1409(predicted CDP-diglyceride synthase) Cluster4920 1 0 0 1 0 0 0 ROD_16321(conserved hypothetical protein) b1410(predicted hydrolase) Cluster4921 1 0 0 1 0 0 0 ROD_16311(possible phosphatase) b1411(predicted phosphatase inner membrane protein) Cluster4922 1 0 0 0 0 0 1 ROD_16181(putative membrane protein) SL1344_1560(putative membrane protein) Cluster4923 1 0 0 1 0 0 0 ROD_15961(putative transcriptional regulator) b1438(antitoxin for the HicAB toxin-antitoxin system; mutational suppressor of null rpoE lethality) Cluster4924 1 0 0 0 0 0 1 ROD_15651(conserved hypothetical protein) SL1344_1504(conserved hypothetical protein) Cluster4925 2 0 0 0 0 0 0 ROD_12371(putative transmembrane transporter),ROD_12491(putative transmembrane transporter) Cluster4926 1 0 0 0 0 0 1 ROD_12111(putative T3SS effector protein EspK) SL1344_2546(leucine rich hypothetical protein) Cluster4927 1 0 0 0 0 0 1 ROD_10831(T3SS effector protein NleB1) SL1344_4096(conserved hypothetical protein) Cluster4928 1 0 0 0 0 0 1 ROD_09351(putative phage repressor protein) SL1344_2633(putative repressor protein) Cluster4929 2 0 0 0 0 0 0 ROD_05791(T3SS effector protein NleD),ROD_38691(T3SS effector protein NleD) Cluster4930 1 0 0 1 0 0 0 ROD_04051(Ferric ABC transporter permease protein) pseudob0263(unknown) Cluster4931 1 0 0 1 0 0 0 ROD_04041(Fe(3+) ions import ATP-binding protein FbpC (ec 3.6.3.30)) b0262(CP4-6 prophage; predicted ferric transporter subunit) Cluster4932 1 0 0 1 0 0 0 ROD_03871(putative xanthine dehydrogenase iron-sulfur-binding subunit) b0286(PaoABC aldehyde oxidoreductase, 2Fe-2S subunit) Cluster4933 1 0 0 1 0 0 0 ROD_03861(putative xanthine dehydrogenase, FAD-binding subunit) b0285(PaoABC aldehyde oxidoreductase, FAD-containing subunit) Cluster4934 1 0 0 1 0 0 0 ROD_03851(putative xanthine dehydrogenase, molybdenum-binding subunit) b0284(PaoABC aldehyde oxidoreductase, Moco-containing subunit) Cluster4935 1 0 0 1 0 0 0 ROD_03841(conserved hypothetical protein) b0283(moco insertion factor for PaoABC aldehyde oxidoreductase) Cluster4936 2 0 0 0 0 0 0 ROD_02941(putative phage repressor protein),ROD_46901(putative phage repressor protein) Cluster4937 2 0 0 0 0 0 0 ROD_02921(putative phage transposase),ROD_46921(phage transposase) Cluster4938 2 0 0 0 0 0 0 ROD_02911(putative phage transposase),ROD_46931(phage DNA transposition protein) Cluster4939 2 0 0 0 0 0 0 ROD_02861(hypothetical prophage protein),ROD_09421(conserved hypothetical prophage protein) Cluster4940 2 0 0 0 0 0 0 ROD_02611(putative phage portal protein),ROD_47171(putative phage portal protein) Cluster4941 2 0 0 0 0 0 0 ROD_02561(putative phage major capsid protein),ROD_47221(phage major head subunit) Cluster4942 2 0 0 0 0 0 0 ROD_02541(hypothetical prophage protein),ROD_47241(putative prophage membrane protein) Cluster4943 2 0 0 0 0 0 0 ROD_02461(putative phage base plate assembly protein),ROD_47331(phage baseplate assembly protein) Cluster4944 1 0 0 0 0 0 1 ROD_00511(putative adhesin autotransporter) SL1344_2474(host colonisation factor (ShdA)) Cluster4945 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_9_5358440-5362867.5(Predicted hydrolase (HAD superfamily)) SL1344_0708(putative glycosyl transferase) Cluster4946 0 0 1 0 0 1 0 Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.5(Vi polysaccharide export inner membrane protein VexD,Capsule polysaccharide export protein,polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family) t4345(Vi polysaccharide export inner-membrane protein) Cluster4947 1 0 1 0 0 0 0 ROD_49781(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.28(hypothetical protein) Cluster4948 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.27(hypothetical protein) b2625(CP4-57 prophage; predicted protein) Cluster4949 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.23(Inner membrane protein yeeR) b2001(CP4-44 prophage; predicted membrane protein) Cluster4950 1 0 1 0 0 0 0 ROD_49681(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.17(hypothetical protein) Cluster4951 1 0 1 0 0 0 0 pseudoROD_41081(fertility inhibition protein (conjugal transfer repressor)(pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.57(Conjugal transfer repressor,conjugal transfer fertility inhibition protein FinO,ProQ/FINO family) Cluster4952 1 0 1 0 0 0 0 ROD_49801(putative haemolysin expression regulatory protein) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.53(Hemolysin expression-modulating protein Hha,gene expression modulator,Haemolysin expression modulating protein) Cluster4953 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.47(Antitoxin PemI,antitoxin ChpS,Growth regulator) b2783(antitoxin of the ChpA-ChpR toxin-antitoxin system) Cluster4954 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.18(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.180(hypothetical protein) Cluster4955 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.171(Macrolide export ATP-binding/permease protein MacB,outer membrane-specific lipoprotein transporter subunit LolE,lipoprotein releasing system, transmembrane protein, LolC/E family,FtsX-like permease family),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.172(Macrolide export ATP-binding/permease protein MacB,macrolide transporter ATP-binding /permease protein,acidobacterial duplicated orphan permease,FtsX-like permease family) Cluster4956 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.17(Probable multidrug-efflux transporter Rv1258c/MT1297,enterobactin exporter EntS,H+ Antiporter protein,Major Facilitator Superfamily),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.179(Probable multidrug-efflux transporter Rv1258c/MT1297,enterobactin exporter EntS,H+ Antiporter protein,Major Facilitator Superfamily) Cluster4957 1 0 1 0 0 0 0 ROD_38421(putative lyase) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.155(Probable 2-keto-3-deoxy-galactonate aldolase YagE,dihydrodipicolinate synthase,dihydrodipicolinate synthase,Dihydrodipicolinate synthetase family) Cluster4958 1 0 1 0 0 0 0 ROD_36291(putative DNA binding protein) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.111(Group II intron-encoded protein ltrA,Retron-type reverse transcriptase,Reverse transcriptase (RNA-dependent DNA polymerase)) Cluster4959 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_5_5104002-5133359.4(Predicted esterase,alpha/beta hydrolase fold),Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.41(Prolyl oligopeptidase family) Cluster4960 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.996(Domain of unknown function (DUF477)) b2778(predicted protein) Cluster4961 1 0 1 0 0 0 0 ROD_33731(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.95(Fic/DOC family) Cluster4962 1 0 1 0 0 0 0 ROD_43131(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.928(D-3-phosphoglycerate dehydrogenase,D-3-phosphoglycerate dehydrogenase,Phosphoserine aminotransferase,phosphoglycerate dehydrogenase,D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain) Cluster4963 1 0 1 0 0 0 0 ROD_28731(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.909(hypothetical protein) Cluster4964 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.9(Domain of unknown function (DUF1788)) SL1344_4426(conserved hypothetical protein) Cluster4965 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.888(Nicotinate dehydrogenase FAD-subunit,xanthine dehydrogenase subunit XdhB,Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A,xanthine dehydrogenase, small subunit,FAD binding domain in molybdopterin dehydrogenase) b2867(xanthine dehydrogenase, FAD-binding subunit) Cluster4966 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.879(putative selenium-dependent hydroxylase accessory protein YqeC) b2876(conserved protein) Cluster4967 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.875(putative oxidoreductase,Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A,probable selenate reductase, FAD-binding subunit,FAD binding domain in molybdopterin dehydrogenase) b2880(predicted oxidoreductase) Cluster4968 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.874(4-hydroxybenzoyl-CoA reductase subunit alpha,putative hypoxanthine oxidase,Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs,probable selenate reductase, molybdenum-binding subunit,Molybdopterin-binding domain of aldehyde dehydrogenase) b2881(probable hypoxanthine oxidase, molybdopterin-binding/Fe-S binding) Cluster4969 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.873(Xanthine permease XanQ,uracil transporter,uracil-xanthine permease,Permease family) b2882(xanthine permease) Cluster4970 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.867(hypothetical protein) b4684(expressed protein) Cluster4971 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.840(LysR substrate binding domain) pseudob2915(unknown) Cluster4972 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.838(Methylmalonyl-CoA mutase,methylmalonyl-CoA mutase,methylmalonyl-CoA mutase N-terminal domain,Methylmalonyl-CoA mutase) b2917(methylmalonyl-CoA mutase) Cluster4973 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.837(hypothetical protein) b2921(predicted DNA-binding transcriptional regulator) Cluster4974 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.823(Pantothenate kinase,nucleoside triphosphate hydrolase domain-containing protein,pantothenate kinase) b2928(conserved protein with nucleoside triphosphate hydrolase domain) Cluster4975 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.821(Fructose-1,6-bisphosphatase 2 class 2,fructose-1,6-bisphosphatase II-like protein,Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins,fructose-1,6-bisphosphatase, class II,Bacterial fructose-1,6-bisphosphatase, glpX-encoded) b2930(fructose 1,6 bisphosphatase isozyme) Cluster4976 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.819(EIICBA-Mtl,PTS system mannitol-specific transporter subunit IICBA,Phosphotransferase system, galactitol-specific IIB component,PTS system, mannitol-specific IIC component,Phosphotransferase system, EIIC) b2933(predicted fused mannitol-specific PTS enzymes: IIB component/IIC component) Cluster4977 1 0 1 0 0 0 0 ROD_19941(putative prophage lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.817(Modulator of FtsH protease HflC,FtsH protease regulator HflC,Uncharacterized protein conserved in bacteria,HflC protein,SPFH domain / Band 7 family) Cluster4978 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.813(hypothetical protein) SL1344_3061(putative outer membrane lipoprotein) Cluster4979 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.811(Protein of unknown function (DUF2684)) SL1344_3064(putative inner membrane protein) Cluster4980 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.753(Cholera toxin secretion protein epsM,putative general secretion pathway protein YghD,General secretion pathway, M protein) b2968(predicted secretion pathway M-type protein, membrane anchored) Cluster4981 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.752(Cholera toxin secretion protein epsL,GspL-like protein,Type II secretory pathway, component PulL,type II secretion system protein L,GspL cytoplasmic actin-ATPase-like region) pseudob2969(unknown) Cluster4982 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.742(hypothetical protein) b2971(predicted protein) Cluster4983 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.740(Procyclic acidic repetitive protein (PARP)) b4466(predicted inner membrane lipoprotein) Cluster4984 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.737(Malate synthase G,malate synthase G,malate synthase G,Malate synthase) b2976(malate synthase G) Cluster4985 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.735(Lactate utilization protein A,glycolate oxidase iron-sulfur subunit,Fe-S oxidoreductase,glycerol-3-phosphate dehydrogenase, anaerobic, C subunit,Cysteine-rich domain) b4467(glycolate oxidase 4Fe-4S iron-sulfur cluster subunit) Cluster4986 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.734(Uncharacterized FAD-linked oxidoreductase Rv2280,glycolate oxidase FAD binding subunit,glycolate oxidase, subunit GlcD,FAD binding domain) b4468(glycolate oxidase FAD binding subunit) Cluster4987 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.733(Uncharacterized FAD-linked oxidoreductase Rv2280,glycolate oxidase subunit GlcD,Fe-S oxidoreductase,glycolate oxidase, subunit GlcD,FAD linked oxidases, C-terminal domain) b2979(glycolate oxidase subunit, FAD-linked) Cluster4988 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.732(Pyruvate dehydrogenase complex repressor,DNA-binding transcriptional regulator GlcC,Transcriptional regulators,trehalose operon repressor,FCD domain) b2980(DNA-binding transcriptional dual regulator, glycolate-binding) Cluster4989 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.731(hypothetical protein) pseudob2981(unknown) Cluster4990 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.722(Inner membrane protein yghQ,colanic acid exporter,Polysaccharide biosynthesis protein) b2983(predicted inner membrane protein) Cluster4991 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.721(thymidylate kinase,thymidylate kinase) b2984(predicted ATP-binding protein) Cluster4992 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.720(hypothetical protein) b2985(predicted ATP-binding protein) Cluster4993 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.719(thymidylate kinase) b2986(predicted ATP-binding protein) Cluster4994 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.695(Protein of unknown function (DUF3828)) b3013(conserved protein) Cluster4995 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.694(Murein-lipoprotein,putative outer membrane lipoprotein) b3014(outer membrane lipoprotein, Lpp paralog) Cluster4996 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.692(Pyruvate dehydrogenase complex repressor,DNA-binding transcriptional repressor UxuR,Transcriptional regulators,phosphonate utilization associated transcriptional regulator,Bacterial regulatory proteins, gntR family) SL1344_3060(putative GntR-family regulatory protein) Cluster4997 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.691(Mannitol 2-dehydrogenase,D-mannonate oxidoreductase,Mannitol-1-phosphate/altronate dehydrogenases,Mannitol dehydrogenase C-terminal domain) SL1344_3059(putative oxidoreductase) Cluster4998 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.689(Ureidoglycolate dehydrogenase,ureidoglycolate dehydrogenase,Malate/L-lactate dehydrogenases,ureidoglycolate dehydrogenase,Malate/L-lactate dehydrogenase) SL1344_3057(putative oxidoreductase) Cluster4999 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.687(2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM,TRAP-type C4-dicarboxylate transport system, small permease component,Tripartite ATP-independent periplasmic transporters, DctQ component) SL1344_3144(possible membrane transport protein) Cluster5000 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.686(Neu5Ac permease,L-dehydroascorbate transporter large permease subunit,TRAP-type C4-dicarboxylate transport system, small permease component,TRAP transporter, DctM subunit,DctM-like transporters) SL1344_3145(decarboxylate transporter) Cluster5001 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.682(Putative binding protein ygiS precursor,putative ABC transporter periplasmic-binding protein,ABC-type oligopeptide transport system, periplasmic component,nickel ABC transporter, nickel/metallophore periplasmic binding protein,Bacterial extracellular solute-binding proteins, family 5 Middle) b3020(predicted transporter subunit: periplasmic-binding component of ABC superfamily) Cluster5002 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.677(Inner membrane protein ygiZ) b3027(inner membrane protein) Cluster5003 1 0 1 0 0 0 0 ROD_44051(Hcp family T6SS protein CtsH4) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.675(Secreted protein hcp,Hemolysin-coregulated protein (uncharacterized),type VI secretion system effector, Hcp1 family,Protein of unknown function (DUF796)) Cluster5004 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.577(Putative reactive intermediate deaminase TdcF,putative endoribonuclease L-PSP,putative endoribonuclease L-PSP,Endoribonuclease L-PSP) b3113(predicted L-PSP (mRNA) endoribonuclease) Cluster5005 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.565(HtrA suppressor protein SohA,putative regulator PrlF,transcriptional regulator, AbrB family) b3129(antitoxin of the SohA(PrlF)-YhaV toxin-antitoxin system) Cluster5006 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.564(Toxin YhaV,Toxin with endonuclease activity YhaV) b3130(toxin of the SohB(PrlF)-YhaV toxin-antitoxin system) Cluster5007 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.557(N-acetylglucosamine-6-phosphate deacetylase,N-acetylglucosamine-6-phosphate deacetylase,Metal-dependent hydrolase involved in phosphonate metabolism,N-acetylglucosamine-6-phosphate deacetylase,Amidohydrolase family) pseudob3135(unknown) Cluster5008 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.554(EIIAB-Man,PTS system N-acetylgalactosamine-specific transporter subunit IIB,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,PTS system, mannose/fructose/sorbose family, IIB component,PTS system sorbose subfamily IIB component) b3138(N-acetylgalactosamine-specific enzyme IIB component of PTS) Cluster5009 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.553(PTS system N-acetylgalactosamine-specific EIIC component 1,PTS system N-acetylgalactosamine-specific transporter subunit IIC,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC,PTS system, mannose/fructose/sorbose family, IIC component,PTS system sorbose-specific iic component) b3139(N-acetylgalactosamine-specific enzyme IIC component of PTS) Cluster5010 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.552(PTS system mannose-specific EIID component,PTS system N-acetylgalactosamine-specific transporter subunit IID,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,PTS system, mannose/fructose/sorbose family, IID component,PTS system mannose/fructose/sorbose family IID component) b3140(N-acetylgalactosamine-specific enzyme IID component of PTS) Cluster5011 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.521(Putative phosphoethanolamine transferase yhbX,hypothetical protein,Predicted membrane-associated, metal-dependent hydrolase,Sulfatase) b3173(predicted hydrolase, inner membrane) Cluster5012 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4904(Integrase core domain),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.164(Integrase core domain) Cluster5013 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4869(hypothetical protein,Bacterial protein of unknown function (DUF905)) b0249(CP4-6 prophage; predicted protein) Cluster5014 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4820(hypothetical protein,Uncharacterized protein conserved in bacteria,Bacterial protein of unknown function (DUF937)) b3698(conserved protein, DUF937 family) Cluster5015 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4811(Tryptophanase,tryptophanase/L-cysteine desulfhydrase, PLP-dependent,tryptophanase,Beta-eliminating lyase) b3708(tryptophanase/L-cysteine desulfhydrase, PLP-dependent) Cluster5016 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4810(Low affinity tryptophan permease,tryptophan permease TnaB,aromatic amino acid transport protein,Tryptophan/tyrosine permease family) b3709(tryptophan transporter of low affinity) Cluster5017 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4803(CreB-regulated gene B protein,putative inner membrane protein) b3716(inner membrane protein, creBC regulon) Cluster5018 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4802(Uncharacterised protein family (UPF0167)) b3717(conserved protein, UPF0167 family) Cluster5019 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4723(Arylsulfatase,arylsulfatase,Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily,choline-sulfatase,Sulfatase) b3801(acrylsulfatase-like enzyme) Cluster5020 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4690(3-hexulose-6-phosphate isomerase,DNA-binding transcriptional regulator HexR,Uncharacterized protein containing SIS (Sugar ISomerase) phosphosugar binding domain,6-phospho 3-hexuloisomerase,SIS domain) SL1344_2740(6-phospho 3-hexuloisomerase) Cluster5021 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4643(hypothetical protein,hypothetical protein,Bacterial protein of unknown function (DUF945)) b3861(conserved protein, DUF945 family) Cluster5022 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4633(hypothetical protein) b4686(expressed protein) Cluster5023 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4615(hypothetical protein) SL1344_3979(conserved hypothetical protein) Cluster5024 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4614(putative transcriptional regulator,putative zinc finger/helix-turn-helix protein, YgiT family,Helix-turn-helix) SL1344_3980(putative DNA-binding protein) Cluster5025 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4611(Ribbon-helix-helix protein, copG family) b3889(predicted transcriptional regulator) Cluster5026 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4579(Universal stress protein A,universal stress protein UspD,Universal stress protein family) b3923(stress-induced protein) Cluster5027 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4565(hypothetical protein,Uncharacterized distant relative of cell wall-associated hydrolases,Orthopoxvirus protein of unknown function (DUF830)) b3937(conserved protein, DUF830 family) Cluster5028 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4486(hypothetical protein) b4011(conserved stress-induced protein) Cluster5029 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4383(hypothetical protein) b4622(hypothetical protein) Cluster5030 1 0 1 0 0 0 0 ROD_41311(putative DNA binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4335(hypothetical protein) Cluster5031 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4330(hypothetical protein) b4128(predicted protein) Cluster5032 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4248(succinate dehydrogenase flavoprotein subunit,Aspartate oxidase,L-aspartate oxidase,FAD binding domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4438(succinate dehydrogenase flavoprotein subunit,Aspartate oxidase,L-aspartate oxidase,FAD binding domain) Cluster5033 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4246(Carnitinyl-CoA dehydratase,enoyl-CoA hydratase,phenylacetate degradation probable enoyl-CoA hydratase PaaB,Enoyl-CoA hydratase/isomerase family),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4436(Carnitinyl-CoA dehydratase,3-hydroxybutyryl-CoA dehydratase,naphthoate synthase,Enoyl-CoA hydratase/isomerase family) Cluster5034 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4199(hypothetical protein) b4253(predicted protein) Cluster5035 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4181(Uncharacterized HTH-type transcriptional regulator RhmR,DNA-binding transcriptional regulator KdgR,beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family,Bacterial transcriptional regulator) SL1344_3500(putative IclR-family transcriptional regulator) Cluster5036 1 0 1 0 0 0 0 ROD_03801(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4178(4-hydroxythreonine-4-phosphate dehydrogenase 2,4-hydroxythreonine-4-phosphate dehydrogenase,4-hydroxythreonine-4-phosphate dehydrogenase,Pyridoxal phosphate biosynthetic protein PdxA) Cluster5037 1 0 1 0 0 0 0 ROD_03791(Major Facilitator Superfamily transporter) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4177(D-glucarate permease,putative 3-hydroxyphenylpropionic transporter MhpT,Arabinose efflux permease,D-galactonate transporter,Major Facilitator Superfamily) Cluster5038 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4159(Transposase) pseudob4561(unknown) Cluster5039 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4156(hypothetical protein) pseudob4286(unknown) Cluster5040 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4109(Deoxyribonucleoside regulator,transcriptional regulator LsrR,Transcriptional regulator, contains sigma factor-related N-terminal domain,Putative sugar-binding domain) b4295(predicted DNA-binding transcriptional regulator; KpLE2 phage-like element) Cluster5041 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4108(5-keto-D-gluconate transporter,high-affinity gluconate transporter,H+/gluconate symporter and related permeases,transporter, gluconate:H+ symporter (GntP) family,GntP family permease) b4296(KpLE2 phage-like element; predicted transporter) Cluster5042 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4105(Transcriptional regulator kdgR,DNA-binding transcriptional regulator KdgR,beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family,Bacterial transcriptional regulator) b4299(KpLE2 phage-like element; predicted DNA-binding transcriptional regulator) Cluster5043 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4097(Putative zinc ribbon domain) pseudob4656(unknown) Cluster5044 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4095(Predicted acetyltransferase,ribosomal-protein-alanine acetyltransferase,Acetyltransferase (GNAT) family) b4307(KpLE2 phage-like element; predicted acetyltransferase) Cluster5045 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4090(Domain of unknown function (DUF303)) b4309(9-O-acetyl N-acetylneuraminic acid esterase) Cluster5046 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4088(Porin NanC,outer membrane porin L,Oligogalacturonate-specific porin protein (KdgM)) b4311(N-acetylnuraminic acid outer membrane channel protein) Cluster5047 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4076(Gnt-III system,fructuronate transporter,H+/gluconate symporter and related permeases,transporter, gluconate:H+ symporter (GntP) family,GntP family permease) b4321(fructuronate transporter) Cluster5048 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4071(Protein of unknown function (DUF2686)) b4325(predicted protein) Cluster5049 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4065(RNA 2'-phosphotransferase,RNA 2'-phosphotransferase, Tpt1 / KptA family) b4331(RNA 2'-phosphotransferase) Cluster5050 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4057(hypothetical protein,conserved hypothetical protein,Putative transposase, YhgA-like) pseudob4339(unknown) Cluster5051 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3944(hypothetical protein,plasmid maintenance protein CcdA,Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid,Post-segregation antitoxin CcdA),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.129(hypothetical protein,plasmid maintenance protein CcdA,Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid,Post-segregation antitoxin CcdA) Cluster5052 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3943(hypothetical protein,plasmid maintenance protein CcdB,CcdB protein),Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.128(hypothetical protein,plasmid maintenance protein CcdB,CcdB protein) Cluster5053 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3852(hypothetical protein,conserved hypothetical protein,Putative transposase, YhgA-like) b0132(predicted transposase) Cluster5054 1 0 1 0 0 0 0 ROD_02281(lateral flagellar export/assembly protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3753(Flagellar biosynthetic protein flhB,flagellar biosynthesis protein FlhB,flagellar biosynthetic protein FlhB,FlhB HrpN YscU SpaS Family) Cluster5055 1 0 1 0 0 0 0 ROD_02291(flagellar biosynthetic protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3752(flagellar biosynthesis protein FliR,Flagellar biosynthesis pathway, component FliR,flagellar biosynthetic protein FliR,Bacterial export proteins, family 1) Cluster5056 1 0 1 0 0 0 0 ROD_02301(lateral flagellar export/assembly protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3751(Flagellar biosynthetic protein FliQ,flagellar biosynthesis protein FliQ,Type III secretory pathway, component EscS,flagellar biosynthetic protein FliQ,Bacterial export proteins, family 3) Cluster5057 1 0 1 0 0 0 0 ROD_02311(lateral flagellar export/assembly protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3750(Flagellar biosynthetic protein fliP precursor,flagellar biosynthesis protein FliP,Type III secretory pathway, component EscR,flagellar biosynthetic protein FliP,FliP family) Cluster5058 1 0 1 0 0 0 0 ROD_02321(lateral flagellar C-ring switch protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3749(Flagellar motor switch protein FliN,flagellar motor switch protein,Flagellar motor switch/type III secretory pathway protein,flagellar motor switch protein FliN,Surface presentation of antigens (SPOA)) Cluster5059 1 0 1 0 0 0 0 ROD_02331(lateral flagellar C-ring switch protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3748(flagellar motor switch protein FliM,Flagellar motor switch protein,flagellar motor switch protein FliM,Surface presentation of antigens (SPOA)) Cluster5060 1 0 1 0 0 0 0 ROD_02351(lateral flagellar RpoN-interacting regulatory protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3747(Nif-specific regulatory protein,anaerobic nitric oxide reductase transcription regulator,Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,Nif-specific regulatory protein,Sigma-54 interaction domain) Cluster5061 1 0 1 0 0 0 0 ROD_02361(lateral flagellar basal body component protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3746(flagellar hook-basal body protein FliE,flagellar hook-basal body complex protein FliE,Flagellar hook-basal body complex protein FliE) Cluster5062 1 0 1 0 0 0 0 ROD_02371(lateral flagellar M-ring protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3745(Flagellar M-ring protein,flagellar MS-ring protein,Type III secretory pathway, lipoprotein EscJ,flagellar M-ring protein FliF,Secretory protein of YscJ/FliF family) Cluster5063 1 0 1 0 0 0 0 pseudoROD_02381(lateral flagellar C-ring switch protein (fragment)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3744(Flagellar motor switch protein FliG,flagellar motor switch protein G,flagellar motor switch protein FliG,FliG C-terminal domain) Cluster5064 1 0 1 0 0 0 0 pseudoROD_02951(lateral flagellar export/assembly protein (fragment)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3742(Flagellum-specific ATP synthase,flagellum-specific ATP synthase,F0F1-type ATP synthase, beta subunit,flagellar protein export ATPase FliI,ATP synthase alpha/beta family, nucleotide-binding domain) Cluster5065 1 0 1 0 0 0 0 ROD_02961(lateral flagellar export/assembly protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3741(flagellar export protein FliJ,Flagellar FliJ protein) Cluster5066 1 0 1 0 0 0 0 ROD_02971(glycerol-3-phosphate cytidylyltransferase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3740(Glycerol-3-phosphate cytidylyltransferase,bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase,Cytidylyltransferase,glycerol-3-phosphate cytidylyltransferase,Cytidylyltransferase) Cluster5067 1 0 1 0 0 0 0 pseudoROD_03001(putative glysosyltransferase (pseudogene)) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3735(putative glycosyl transferase,colanic acid biosynthesis glycosyltransferase WcaA,Glycosyl transferase family 2) Cluster5068 1 0 1 0 0 0 0 ROD_03011(lateral flagellar associated protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3734(hypothetical protein) Cluster5069 1 0 1 0 0 0 0 ROD_03021(lateral flagellar chaperone protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3733(FlgN protein) Cluster5070 1 0 1 0 0 0 0 ROD_03031(lateral flagellar anti-sigma factor 28 protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3732(anti-sigma28 factor FlgM,flagellar biosynthesis anti-sigma factor FlgM,Anti-sigma-28 factor, FlgM) Cluster5071 1 0 1 0 0 0 0 ROD_03041(lateral flagellar P-ring addition protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3731(flagellar basal body P-ring biosynthesis protein FlgA,flagella basal body P-ring formation protein FlgA) Cluster5072 1 0 1 0 0 0 0 ROD_03051(lateral flagellar rod protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3730(Putative proximal rod protein,flagellar basal body rod protein FlgB,Flagellar basal body protein,flagellar basal-body rod protein FlgB) Cluster5073 1 0 1 0 0 0 0 ROD_03061(lateral flagellar basal-body rod protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3729(Putative proximal rod protein,flagellar basal body rod protein FlgC,Flagellar basal body rod protein,flagellar basal-body rod protein FlgC,Domain of unknown function (DUF1078)) Cluster5074 1 0 1 0 0 0 0 ROD_03071(lateral flagellar rod protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3728(Basal-body rod modification protein flgD,flagellar basal body rod modification protein,Flagellar hook capping protein,Flagellar hook capping protein) Cluster5075 1 0 1 0 0 0 0 ROD_03081(lateral flagellar hook protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3727(Flagellar hook protein flgE,flagellar hook protein FlgE,Flagellar hook protein FlgE,flagellar hook-basal body protein,Flagellar basal body protein FlaE) Cluster5076 1 0 1 0 0 0 0 ROD_03141(lateral flagellar peptidoglycan hydrolase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3722(Peptidoglycan hydrolase flgJ,peptidoglycan hydrolase,Rod binding protein,flagellar rod assembly protein/muramidase FlgJ,Rod binding protein) Cluster5077 1 0 1 0 0 0 0 ROD_03151(lateral flagellar hook associated protein 1) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3721(Flagellar hook-associated protein 1,flagellar hook-associated protein FlgK,Flagellar hook protein FlgE,flagellar hook-associated protein FlgK,Domain of unknown function (DUF1078)) Cluster5078 1 0 1 0 0 0 0 ROD_03161(lateral flagellar hook associated protein 3) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3720(Hook-filament junction protein,flagellar hook-associated protein FlgL,flagellar hook-associated protein 3,Bacterial flagellin N-terminal helical region) Cluster5079 1 0 1 0 0 0 0 ROD_03171(lateral flagellar putative hook associated protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3719(hypothetical protein) Cluster5080 1 0 1 0 0 0 0 ROD_03191(lateral flagellar transmembrane regulator) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3718(DNA-binding transcriptional activator CadC,heavy metal response regulator,Transcriptional regulatory protein, C terminal) Cluster5081 1 0 1 0 0 0 0 ROD_03211(lateral flagellar flagellin) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3717(Flagellin 1,flagellin,Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis,flagellar hook-associated protein 3,Bacterial flagellin N-terminal helical region) Cluster5082 1 0 1 0 0 0 0 ROD_03221(lateral flagellar hook associated protein 2) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3716(Flagellar cap protein,flagellar capping protein,Flagellar hook-associated protein 2 C-terminus) Cluster5083 1 0 1 0 0 0 0 ROD_03231(lateral flagellar chaperone protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3715(Flagellar protein fliS,flagellar protein FliS,flagellar protein FliS,Flagellar protein FliS) Cluster5084 1 0 1 0 0 0 0 ROD_03241(lateral flagellar chaperone protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3714(hypothetical protein) Cluster5085 1 0 1 0 0 0 0 ROD_03251(lateral flagellar hook length control protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3713(type III secretion system needle length determinant,Flagellar hook-length control protein FliK) Cluster5086 1 0 1 0 0 0 0 ROD_03261(lateral flagellar associated protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3712(flagellar basal body-associated protein FliL,Flagellar basal body-associated protein FliL) Cluster5087 1 0 1 0 0 0 0 ROD_03271(lateral flagellar sigma factor 28 protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3711(Sigma-F factor,flagellar biosynthesis sigma factor,RNA polymerase sigma factor, FliA/WhiG family,Sigma-70, region 4) Cluster5088 1 0 1 0 0 0 0 ROD_03281(lateral flagellar motor protein A) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3710(Chemotaxis protein MotA,flagellar motor protein MotA,flagellar motor stator protein MotA,MotA/TolQ/ExbB proton channel family) Cluster5089 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3686(Inner membrane protein yagU,Predicted periplasmic/secreted protein,Protein of unknown function (DUF1440)) b0287(inner membrane protein, DUF1440 family) Cluster5090 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3676(Uncharacterized membrane protein ykgR) b4671(expressed protein) Cluster5091 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.367(hypothetical protein,Tfp pilus assembly protein FimT,type II secretion system protein H,Type II transport protein GspH) b3329(predicted general secretory pathway component, cryptic) Cluster5092 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3663(Lactate utilization protein A,glycolate oxidase iron-sulfur subunit,Fe-S oxidoreductase,glycerol-3-phosphate dehydrogenase, anaerobic, C subunit,Cysteine-rich domain) b0306(predicted oxidoreductase) Cluster5093 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3662(Lactate utilization protein B,sn-glycerol-3-phosphate dehydrogenase subunit C,Fe-S oxidoreductase,iron-sulfur cluster-binding protein,Uncharacterised ACR, YkgG family COG1556) b0307(predicted electron transport protein with ferridoxin-like domai) Cluster5094 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3661(Lactate utilization protein C,Uncharacterised ACR, YkgG family COG1556) b0308(predicted transporter) Cluster5095 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3660(hypothetical protein) b0310(predicted inner membrane protein) Cluster5096 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3649(Cyclic di-GMP phosphodiesterase yahA,phage resistance protein,Predicted signal transduction protein containing sensor and EAL domains,EAL domain) b0315(c-di-GMP-specific phosphodiesterase) Cluster5097 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3647(Protein of unknown function (DUF1097)) b0317(predicted inner membrane protein) Cluster5098 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3645(Protein of unknown function (DUF2877)) b0319(predicted protein) Cluster5099 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3629(Galactoside O-acetyltransferase,galactoside O-acetyltransferase,Acetyltransferase (isoleucine patch superfamily),sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family,Bacterial transferase hexapeptide (six repeats)) b0342(thiogalactoside acetyltransferase) Cluster5100 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3616(S-formylglutathione hydrolase frmB,Predicted hydrolase of the alpha/beta superfamily,S-formylglutathione hydrolase,Putative esterase) b0355(S-formylglutathione hydrolase) Cluster5101 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3525(hypothetical protein,Uncharacterized conserved protein,Protein of unknown function (DUF1428)) b0456(conserved protein, DUF1428 family) Cluster5102 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3493(Glutaminase 1,glutaminase,glutaminase A,Glutaminase) b0485(glutaminase) Cluster5103 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3492(Inner membrane transport protein YbaT,putative fructoselysine transporter,amino acid transporter,Amino acid permease) b0486(predicted transporter) Cluster5104 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3490(hypothetical protein) SL1344_0649(putative conserved hypothetical protein) Cluster5105 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3443(hypothetical protein) b0567(predicted protein) Cluster5106 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3442(bacteriophage N4 receptor, outer membrane subunit,Putative Zn-dependent protease, contains TPR repeats,putative PEP-CTERM system TPR-repeat lipoprotein) b0568(bacteriophage N4 receptor, outer membrane subunit) Cluster5107 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3441(bacteriophage N4 adsorption protein B,Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB,type IV-A pilus assembly ATPase PilB,GSPII_E N-terminal domain) b0569(bacteriophage N4 receptor, inner membrane subunit) Cluster5108 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3354(Polar organelle development protein,3-carboxymuconate cyclase,Sel1 repeat) b0647(conserved protein, Sel1 family) Cluster5109 1 0 1 0 0 0 0 ROD_15121(possible membrane transport protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3324(transporter, divalent anion:Na+ symporter (DASS) family,Sodium:sulfate symporter transmembrane region) Cluster5110 1 0 1 0 0 0 0 ROD_15141(putative integral membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3321(hypothetical protein,integral membrane protein, YkoY family,Integral membrane protein TerC family) Cluster5111 1 0 1 0 0 0 0 ROD_43121(conserved hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3288(Putative regulator of ribonuclease activity,hypothetical protein,4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase,Demethylmenaquinone methyltransferase) Cluster5112 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.325(methionine gamma-lyase,methionine gamma-lyase,Aminotransferase class I and II) b3376(conserved protein) Cluster5113 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.324(Protein of unknown function) b3377(predicted inner membrane protein) Cluster5114 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.323(Protein of unknown function DUF2620) b3378(predicted protein) Cluster5115 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.322(Phosphotriesterase homology protein,putative hydrolase,Phosphotriesterase family) b3379(predicted hydrolase) Cluster5116 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3211(Inner membrane protein YbhL,Inhibitor of apoptosis-promoting Bax1) b0787(inner membrane protein, UPF0005 family) Cluster5117 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.321(hypothetical protein,putative mutase,Predicted phosphoglycerate mutase, AP superfamily,phosphopentomutase,Metalloenzyme superfamily) b3380(predicted mutase) Cluster5118 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3200(Swarming motility protein ybiA,Pyrimidine deaminase,conserved hypothetical protein,Domain of unknown function (DUF1768)) b0798(conserved protein, DUF1768 family) Cluster5119 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.320(Alanine racemase, N-terminal domain) b3381(predicted amino acid racemase) Cluster5120 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.319(PRD domain protein, EF_0829/AHA_3910 family) b3382(conserved protein) Cluster5121 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.318(hypothetical protein) b3383(conserved protein) Cluster5122 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3166(Putative cyclic di-GMP phosphodiesterase YliE,RNase II stability modulator,Predicted signal transduction protein containing sensor and EAL domains,EAL domain) b0833(predicted cyclic-di-GMP phosphodiesterase, inner membrane protein) Cluster5123 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3165(Diguanylate cyclase YdeH,diguanylate cyclase,Response regulator containing a CheY-like receiver domain and a GGDEF domain,diguanylate cyclase (GGDEF) domain,GGDEF domain) b0834(predicted diguanylate cyclase) Cluster5124 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3156(hypothetical protein) b0843(predicted protein) Cluster5125 1 0 1 0 0 0 0 ROD_36671(phage tail completion protein R) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3085(P2 phage tail completion protein R (GpR)) Cluster5126 1 0 1 0 0 0 0 ROD_36691(putative prophage lipoprotein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3083(hypothetical protein) Cluster5127 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3082(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_3_5053552-5076227.25(hypothetical protein) Cluster5128 1 0 1 0 0 0 0 ROD_36801(putative prophage membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3072(hypothetical protein) Cluster5129 1 0 1 0 0 0 0 ROD_36811(putative prophage stability/partitioning protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3070(Plasmid stability protein) Cluster5130 1 0 1 0 0 0 0 ROD_36921(hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3060(hypothetical protein) Cluster5131 1 0 1 0 0 0 0 ROD_20001(putative prophage membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3059(hypothetical protein) Cluster5132 1 0 1 0 0 0 0 ROD_20031(hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3056(hypothetical protein) Cluster5133 1 0 1 0 0 0 0 ROD_36981(putative phage repressor protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3052(transcriptional regulator, y4mF family,Helix-turn-helix) Cluster5134 0 0 1 0 0 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3025(hypothetical protein) t1361(hypothetical protein) Cluster5135 1 0 1 0 0 0 0 ROD_09331(putative prophage DNA adenine methylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3003(Modification methylase DpnIIA,DNA adenine methylase,Site-specific DNA methylase,DNA adenine methylase,D12 class N6 adenine-specific DNA methyltransferase) Cluster5136 1 0 1 0 0 0 0 ROD_09371(putative prophage DNA-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3000(hypothetical protein) Cluster5137 1 0 1 0 0 0 0 ROD_09401(putative prophage DNA-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2996(putative secretion ATPase, PEP-CTERM locus subfamily) Cluster5138 0 0 1 0 0 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2993(hypothetical protein) t1388(hypothetical protein) Cluster5139 0 0 1 0 0 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2990(hypothetical protein) t1392(hypothetical protein) Cluster5140 0 0 1 0 0 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2988(hypothetical protein) t1394(hypothetical protein) Cluster5141 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2919(Periplasmic AppA protein precursor,phosphoanhydride phosphorylase,Histidine phosphatase superfamily (branch 2)) b0980(phosphoanhydride phosphorylase) Cluster5142 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2889(Biofilm PGA synthesis protein PgaD,putative PGA biosynthesis protein,poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD) b1021(required for biofilm adhesin polysaccharide PGA synthesis) Cluster5143 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2778(hypothetical protein) b1141(e14 prophage; predicted excisionase) Cluster5144 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2776(hypothetical protein) SL1344_2586(predicted bacteriophage protein) Cluster5145 0 0 1 0 0 1 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2772(Host-nuclease inhibitor protein Gam) t1922(host-nuclease inhibitor protein) Cluster5146 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2767(phage replication protein O, N-terminal domain,Bacteriophage replication protein O) SL1344_2591(bacteriophage replication protein) Cluster5147 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2763(hypothetical protein) b0547(DLP12 prophage; predicted protein) Cluster5148 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2761(82 prophage-derived uncharacterized protein ybcO,Protein of unknown function (DUF1364)) b0549(DLP12 prophage; predicted protein) Cluster5149 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2760(Crossover junction endodeoxyribonuclease rusA,endodeoxyribonuclease RUS,Holliday junction resolvase,Endodeoxyribonuclease RusA) b0550(DLP12 prophage; endonuclease RUS) Cluster5150 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2749(gpW) SL1344_2571(predicted bacteriophage protein) Cluster5151 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2746(Bacteriophage lambda head decoration protein D) SL1344_2568(predicted bacteriophage protein) Cluster5152 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2743(Phage Head-Tail Attachment) SL1344_2565(predicted bacteriophage protein) Cluster5153 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2742(Prophage minor tail protein Z (GPZ)) SL1344_2564(predicted bacteriophage protein) Cluster5154 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2741(Phage minor tail protein U) SL1344_0976(predicted bacteriophage protein) Cluster5155 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2713(hypothetical protein) b1171(predicted protein) Cluster5156 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2712(hypothetical protein) b1172(conserved protein, UPF0757 family) Cluster5157 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2707(Fels-1 Prophage Protein-like) b1177(predicted protein) Cluster5158 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2675(Retron-type reverse transcriptase,Reverse transcriptase (RNA-dependent DNA polymerase)) SL1344_3813(reverse transcriptase) Cluster5159 1 0 1 0 0 0 0 ROD_20841(putative membrane protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2611(PAP2 superfamily) Cluster5160 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2588(Voltage-gated potassium channel Kch,voltage-gated potassium channel,NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding,TrkA-N domain) b1250(voltage-gated potassium channel) Cluster5161 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2579(Protein of unknown function (DUF1482)) b1576(Qin prophage; predicted protein) Cluster5162 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2576(hypothetical protein) b1573(conserved protein, Qin prophage) Cluster5163 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2575(hypothetical protein) b1572(Qin prophage; predicted protein) Cluster5164 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2572(DNA-binding transcriptional regulator DicC) b1569(Qin prophage; DNA-binding transcriptional regulator for DicB) Cluster5165 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2568(Protein of unknown function (DUF1627)) pseudob1361(unknown) Cluster5166 1 0 1 0 0 0 0 ROD_26121(hypothetical prophage protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2561(hypothetical protein) Cluster5167 1 0 1 0 0 0 0 ROD_26111(putative prophage DNA adenine methylase) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2560(Modification methylase DpnIIB,putative methyltransferase,Adenine specific DNA methylase Mod,DNA methylase) Cluster5168 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2520(Caudovirales tail fibre assembly protein),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.13(Caudovirales tail fibre assembly protein) Cluster5169 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2519(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.12(hypothetical protein) Cluster5170 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2518(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.16(hypothetical protein) Cluster5171 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2515(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_4_5076228-5104001.20(hypothetical protein) Cluster5172 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2439(Putative NADH-flavin reductase,NmrA-like family) pseudob4525(unknown) Cluster5173 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2397(hypothetical protein) b1419(predicted protein) Cluster5174 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2344(Extreme acid sensitivity protein,inner membrane transporter YjeM,Amino acid transporters,glutamate:gamma-aminobutyrate antiporter,Amino acid permease) b1492(predicted glutamate:gamma-aminobutyric acid antiporter) Cluster5175 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2342(Peptidase M16 inactive domain) b1494(predicted peptidase) Cluster5176 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2340(Choline-sulfatase,arylsulfatase,Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily,choline-sulfatase,Sulfatase) b1498(conserved protein) Cluster5177 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2339(HTH-type transcriptional regulator gadW,transcriptional regulator YdeO,Adenosine deaminase,YSIRK-targeted surface antigen transcriptional regulator,Bacterial regulatory helix-turn-helix proteins, AraC family) b1499(transcriptional activator for mdtEF) Cluster5178 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2338(Sensor associating factor A) b1500(Two component system connector membrane protein, EvgSA to PhoQP) Cluster5179 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2336(hypothetical protein,P pilus assembly protein, pilin FimA,FimH, mannose binding) b1502(predicted fimbrial-like adhesin protein) Cluster5180 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2335(hypothetical protein,fimbrial-like adhesin protein SfmF,P pilus assembly protein, pilin FimA,Fimbrial protein) b1503(predicted fimbrial-like adhesin protein) Cluster5181 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2334(hypothetical protein,long polar fimbrial protein LpfA,P pilus assembly protein, pilin FimA,Fimbrial protein) b1504(predicted fimbrial-like adhesin protein) Cluster5182 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2311(Diguanylate cyclase YdeH,diguanylate cyclase,Response regulator containing a CheY-like receiver domain and a GGDEF domain,diguanylate cyclase (GGDEF) domain,GGDEF domain) b1535(diguanylate cyclase, required for pgaD induction) Cluster5183 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2294(DMSO reductase iron-sulfur subunit,tetrathionate reductase subunit B,Uncharacterized Fe-S center protein,dimethylsulfoxide reductase, chain B,4Fe-4S binding domain) b1589(oxidoreductase, Fe-S subunit) Cluster5184 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2268(Membrane-associated protein uidC precursor,putative outer membrane porin protein) b1615(predicted outer membrane porin protein) Cluster5185 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2266(Glucuronide carrier protein homolog,glucuronide transporter,sugar (Glycoside-Pentoside-Hexuronide) transporter,Major Facilitator Superfamily) b1616(glucuronide transporter) Cluster5186 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2264(Beta-glucuronidase,beta-D-glucuronidase,Beta-xylo sidase,Glycosyl hydrolases family 2, TIM barrel domain) b1617(beta-D-glucuronidase) Cluster5187 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2262(7-alpha-hydroxysteroid dehydrogenase,7-alpha-hydroxysteroid dehydrogenase,Uncharacterized conserved protein,3-oxoacyl-[acyl-carrier-protein] reductase,short chain dehydrogenase) b1619(7-alpha-hydroxysteroid dehydrogenase, NAD-dependent) Cluster5188 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2217(Fluffing protein,hypothetical protein) b1664(conserved protein) Cluster5189 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2129(hypothetical protein) b1751(predicted protein) Cluster5190 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2095(Inner membrane protein YeaI,response regulator PleD,Response regulator containing a CheY-like receiver domain and a GGDEF domain,diguanylate cyclase (GGDEF) domain,GGDEF domain) b1785(predicted diguanylate cyclase) Cluster5191 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.208(Inner membrane protein yhiM,Protein of unknown function (DUF2776)) b3491(inner membrane protein, DUF1323 family) Cluster5192 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.196(hypothetical protein) pseudob3504(unknown) Cluster5193 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.195(Outer membrane protein slp precursor,Starvation-inducible outer membrane lipoprotein,outer membrane lipoprotein, Slp family,Outer membrane lipoprotein Slp family) b3506(outer membrane lipoprotein) Cluster5194 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.194(Transcriptional regulator gadE,two component system sensor kinase SsrB,Response regulator,Bacterial regulatory proteins, luxR family) b3507(predicted DNA-binding ranscriptional regulator) Cluster5195 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1935(Phage anti-repressor protein,ORF6N domain) SL1344_2578(predicted bacteriophage protein) Cluster5196 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1916(hypothetical protein) SL1344_1975(predicted bacteriophage protein) Cluster5197 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1858(Molecular chaperone Hsp31 and glyoxalase 3,chaperone protein HchA,DJ-1/PfpI family) b1967(Glyoxalase III and Hsp31 molecular chaperone) Cluster5198 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1847(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2730(hypothetical protein) Cluster5199 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1838(Phage-related protein,Phage minor tail protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2532(Phage-related protein,Phage minor tail protein) Cluster5200 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1836(hypothetical protein),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2534(hypothetical protein) Cluster5201 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1835(Phage tail assembly chaperone),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2535(Phage tail assembly chaperone) Cluster5202 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1833(Protein of unknown function (DUF3168)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2537(Protein of unknown function (DUF3168)) Cluster5203 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1832(phage protein, HK97 gp10 family,Bacteriophage protein of unknown function (DUF646)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2538(phage protein, HK97 gp10 family,Bacteriophage protein of unknown function (DUF646)) Cluster5204 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1828(phage prohead protease, HK97 family,Caudovirus prohead protease) SL1344_2212(bacteriophage prohead protease, HK97 family) Cluster5205 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.181(Transcriptional regulator gadE) b3512(DNA-binding transcriptional activator) Cluster5206 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1802(Protein of unknown function (DUF1019)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2571(Protein of unknown function (DUF1019)) Cluster5207 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1795(DicB protein) b1575(Qin prophage; cell division inhibition protein) Cluster5208 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.179(Multidrug resistance protein MdtE precursor,multidrug efflux system protein MdtE,efflux transporter, RND family, MFP subunit,HlyD family secretion protein) b3513(anaerobic multidrug efflux transporter, ArcA-regulated) Cluster5209 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1783(Iron import ATP-binding/permease protein IrtA,cyclic beta-1,2-glucan ABC transporter,ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain,ABC transporter, permease/ATP-binding protein,ABC transporter transmembrane region),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1784(Putative multidrug export ATP-binding/permease protein SAV1866,cyclic beta-1,2-glucan ABC transporter,ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain,lipid A export permease/ATP-binding protein MsbA,ABC transporter) Cluster5210 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1780(Beta-ketoacyl-acyl-carrier-protein synthase I,enterobactin synthase subunit F,Glutamate-1-semialdehyde aminotransferase,polyketide-type polyunsaturated fatty acid synthase PfaA,Beta-ketoacyl synthase, N-terminal domain),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1781(Phenyloxazoline synthase MbtB,peptide synthase,Anthranilate/para-aminobenzoate synthases component I,amino acid adenylation domain,Condensation domain) Cluster5211 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1772(lipopolysaccharide heptosyltransferase I,Glycosyltransferase family 9 (heptosyltransferase)) pseudob4497(unknown) Cluster5212 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.176(HTH-type transcriptional regulator gadW,transcriptional regulator YdeO,Adenosine deaminase,YSIRK-targeted surface antigen transcriptional regulator,Bacterial regulatory helix-turn-helix proteins, AraC family) b3515(transcriptional activator of gadA and gadBC in absence of GadX) Cluster5213 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1758(Colicin I receptor precursor,enterobactin receptor protein,Outer membrane cobalamin receptor protein,TonB-dependent heme/hemoglobin receptor family protein,TonB dependent receptor) pseudob4582(unknown) Cluster5214 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1754(Uncharacterized proteins, LmbE homologs,bacillithiol biosynthesis deacetylase BshB1,GlcNAc-PI de-N-acetylase) b0364(conserved protein) Cluster5215 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1753(Poly-beta-1,6-N-acetyl-D-glucosamine synthase,N-glycosyltransferase,Predicted glycosyl hydrolase,poly-beta-1,6 N-acetyl-D-glucosamine synthase,Glycosyl transferase family 2) b0363(predicted glucosyltransferase) Cluster5216 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1752(Bifunctional protein GlmU,bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase,Acetyltransferase (isoleucine patch superfamily),UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase,Bacterial transferase hexapeptide (six repeats)) pseudob4579(unknown) Cluster5217 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1751(hypothetical protein) b0358(outer membrane protein) Cluster5218 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1744(Protein of unknown function (DUF3279)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4142(Protein of unknown function (DUF3279)) Cluster5219 1 0 1 0 0 0 0 ROD_49821(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1741(hypothetical protein) Cluster5220 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.174(HTH-type transcriptional regulator gadX,DNA-binding transcriptional regulator GadX,Adenosine deaminase,YSIRK-targeted surface antigen transcriptional regulator,Bacterial regulatory helix-turn-helix proteins, AraC family) b3516(DNA-binding transcriptional dual regulator) Cluster5221 1 0 1 0 0 0 0 ROD_07441(iron-chelating periplasmic-binding protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1731(hypothetical protein,corrinoid ABC transporter substrate-binding protein,ABC-type hemin transport system, periplasmic component,putative ABC transporter PGF-CTERM-modified substrate-binding protein,Periplasmic binding protein) Cluster5222 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1712(Protein of unknown function (DUF987)),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4865(Protein of unknown function (DUF987)) Cluster5223 0 0 2 0 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.17(Anaphase-promoting complex, cyclosome, subunit 3),Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.780(Anaphase-promoting complex, cyclosome, subunit 3) Cluster5224 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1696(Toxin YoeB,addiction module toxin, Txe/YoeB family,Plasmid encoded toxin Txe) b4539(toxin of the YoeB-YefM toxin-antitoxin system) Cluster5225 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1681(Glycosyl transferases group 1) b2032(lipopolysaccharide biosynthesis protein) Cluster5226 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1641(Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains) b2070(conserved protein) Cluster5227 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1640(hypothetical protein) b2072(predicted protein) Cluster5228 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1639(Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain,von Willebrand factor type A domain) b2073(conserved protein) Cluster5229 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1630(hypothetical protein,Uncharacterized conserved protein,Domain of unknown function (DUF1508)) b2080(conserved protein, UPF0339 family) Cluster5230 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1627(hypothetical protein) b2085(predicted protein) Cluster5231 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1612(Lysozyme M1 precursor,Lyzozyme M1 (1,4-beta-N-acetylmuramidase),Glycosyl hydrolases family 25) b2102(predicted hydrolase) Cluster5232 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1592(hypothetical protein) b4541(predicted protein) Cluster5233 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1590(gas vesicle protein GvpN,AAA domain (dynein-related subfamily)) b2119(predicted transporter subunit: ATP-binding component of ABC superfamily) Cluster5234 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1589(hypothetical protein) b2120(predicted protein) Cluster5235 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1588(Mg-chelatase subunit ChlD,VWA domain containing CoxE-like protein) b2121(conserved protein) Cluster5236 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1587(SWIM zinc finger) pseudob2122(unknown) Cluster5237 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1548(Pyrimidine-specific ribonucleoside hydrolase rihB,ribonucleoside hydrolase 2,Inosine-uridine preferring nucleoside hydrolase) b2162(ribonucleoside hydrolase 2) Cluster5238 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1547(Regulatory protein YeiL,DNA-binding transcriptional activator YeiL,Cyclic nucleotide-binding domain) b2163(DNA-binding transcriptional activator of stationary phase nitrogen survival) Cluster5239 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1500(hypothetical protein) b4604(hypothetical protein) Cluster5240 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1482(Uncharacterized protein conserved in bacteria,Uncharacterized protein conserved in bacteria (DUF2135)) b2225(conserved protein) Cluster5241 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1481(Predicted secreted protein,Predicted secreted protein (DUF2300)) b2226(predicted protein) Cluster5242 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1480(MG2 domain) pseudob4500(unknown) Cluster5243 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1479(Protein of unknown function (DUF1175)) b2229(predicted protein) Cluster5244 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1478(hypothetical protein,Uncharacterized protein conserved in bacteria,Uncharacterized protein conserved in bacteria (DUF2138)) b2230(conserved protein, DUF2138 family) Cluster5245 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1475(AIDA-I autotransporter precursor,adhesin,Type V secretory pathway, adhesin AidA,outer membrane autotransporter barrel domain,Autotransporter beta-domain) b2233(adhesin) Cluster5246 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1471(hypothetical protein,hypothetical protein,Lipopolysaccharide kinase (Kdo/WaaP) family) b2237(conserved protein, acid-induced) Cluster5247 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1464(hypothetical protein,conserved hypothetical protein) b4543(predicted protein) Cluster5248 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1437(Bacterial leucyl aminopeptidase precursor,Peptidase family M28) b2271(predicted peptidase) Cluster5249 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1436(hypothetical protein,Domain of unknown function (DUF1877)) b2272(conserved protein, DUF1877 family) Cluster5250 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1345(Formyl-coenzyme A transferase,putative CoA-transferase,Predicted acyl-CoA transferases/carnitine dehydratase,formyl-CoA transferase,CoA-transferase family III) b2371(predicted CoA-transferase, NAD(P)-binding) Cluster5251 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1343(Probable oxalyl-CoA decarboxylase,putative oxalyl-CoA decarboxylase,Glyoxylate carboligase,oxalyl-CoA decarboxylase,Thiamine pyrophosphate enzyme, N-terminal TPP binding domain) b2373(oxalyl CoA decarboxylase, ThDP-dependent) Cluster5252 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1342(Formyl-coenzyme A transferase,formyl-coenzyme A transferase,Predicted acyl-CoA transferases/carnitine dehydratase,formyl-CoA transferase,CoA-transferase family III) b2374(formyl-CoA transferase, NAD(P)-binding) Cluster5253 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1340(hypothetical protein) b2376(predicted lipoprotein involved in colanic acid biosynthesis) Cluster5254 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1234(Glycine zipper 2TM domain) b2505(outer membrane lipoprotein) Cluster5255 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1227(Invasin,intimin-like protein SinH,Protein of unknown function (DUF3442)) SL1344_2479(intimin) Cluster5256 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.12(hypothetical protein) SL1344_4433(putative inner membrane protein) Cluster5257 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1196(Sorbitol dehydrogenase,L-threonine 3-dehydrogenase,Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase,L-threonine 3-dehydrogenase,Alcohol dehydrogenase GroES-like domain) b2545(predicted oxidoreductase, Zn-dependent and NAD(P)-binding) Cluster5258 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1195(Ribose transport system permease protein rbsC,ribose ABC transporter permease protein,Predicted ABC-type sugar transport system, permease component,urea ABC transporter, permease protein UrtC,Branched-chain amino acid transport system / permease component) b2546(predicted sugar transporter subunit: membrane component of ABC superfamily) Cluster5259 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1194(Galactose/methyl galactoside import ATP-binding protein MglA,L-arabinose transporter ATP-binding protein,ABC-type Na+ transport system, ATPase component,D-xylose ABC transporter, ATP-binding protein,ABC transporter) b2547(fused predicted sugar transporter subunits of ABC superfamily: ATP-binding components) Cluster5260 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1193(ABC transporter periplasmic-binding protein yphF precursor,D-allose transporter subunit,ABC-type sugar transport system, periplasmic component,rhamnose ABC transporter, rhamnose-binding protein,Periplasmic binding proteins and sugar binding domain of LacI family) b2548(predicted sugar transporter subunit: periplasmic-binding component of ABC superfamily) Cluster5261 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1013(Electron transfer flavoprotein-ubiquinone oxidoreductase,oxidoreductase,Bacterial lipocalin,geranylgeranyl reductase family,FAD dependent oxidoreductase) b2766(predicted oxidoreductase with FAD/NAD(P)-binding domain) Cluster5262 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1012(ferredoxin-like protein FixX,Ferredoxin-like protein) b2767(predicted 4Fe-4S cluster-containing protein) Cluster5263 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1011(hypothetical protein,Glycerol-3-phosphate responsive antiterminator) b2768(predicted anti-terminator regulatory protein) Cluster5264 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1010(Electron transfer flavoprotein large subunit,electron transfer flavoprotein subunit YdiR,Electron transfer flavoprotein FAD-binding domain) b2769(predicted flavoprotein) Cluster5265 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1009(Electron transfer flavoprotein small subunit,putative electron transfer flavoprotein FixA,Electron transfer flavoprotein, beta subunit,Electron transfer flavoprotein domain) b2770(predicted flavoprotein) Cluster5266 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1008(Inner membrane metabolite transport protein ygcS,putative 3-hydroxyphenylpropionic transporter MhpT,Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA),MFS transporter, aromatic acid:H+ symporter (AAHS) family,Sugar (and other) transporter) b2771(predicted transporter) Cluster5267 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1007(Uncharacterized FAD-linked oxidoreductase Rv2280,glycolate oxidase subunit GlcD,Fe-S oxidoreductase,glycolate oxidase, subunit GlcD,FAD binding domain) b4463(predicted FAD containing dehydrogenase) Cluster5268 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1006(2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase,2-deoxy-D-gluconate 3-dehydrogenase,Uncharacterized conserved protein,2-deoxy-D-gluconate 3-dehydrogenase,short chain dehydrogenase) b2774(predicted dehydrogenase) Cluster5269 0 0 1 1 0 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1004(Autoinducer 2 kinase LsrK,autoinducer-2 (AI-2) kinase,Pentose-5-phosphate-3-epimerase,xylulokinase,FGGY family of carbohydrate kinases, C-terminal domain) b2776(predicted kinase) Cluster5270 0 0 1 0 0 0 1 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.10(Putative inner membrane protein (DUF1819)) SL1344_4427(putative inner membrane protein) Cluster5271 0 1 1 0 0 0 0 ENC_46660(P pilus assembly protein, pilin FimA) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3833(Type-1A pilin,putative fimbrial protein SthA,P pilus assembly protein, pilin FimA,Fimbrial protein) Cluster5272 1 1 0 0 0 0 0 ROD_00321(conserved hypothetical protein) ENC_45540(Phosphomannose isomerase) Cluster5273 1 1 0 0 0 0 0 ROD_00311(putative PTS system protein) ENC_45530(Phosphotransferase system, mannose/fructose-specific component IIA) Cluster5274 1 1 0 0 0 0 0 ROD_00301(putative PTS system protein) ENC_45520(Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB) Cluster5275 1 1 0 0 0 0 0 ROD_49141(putative LysR-family transcriptional regulator) ENC_45140(transcriptional regulator, LysR family) Cluster5276 0 1 1 0 0 0 0 ENC_44580(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4147(Uncharacterized protein conserved in bacteria) Cluster5277 1 1 0 0 0 0 0 ROD_08421(conserved hypothetical protein) ENC_44200(Cellulase (glycosyl hydrolase family 5).) Cluster5278 1 1 0 0 0 0 0 ROD_08431(putative LacI-family transcriptional regulator) ENC_44190(Transcriptional regulators) Cluster5279 0 1 0 0 0 0 1 ENC_44110(Helix-turn-helix.) SL1344_2732(putative transcriptional regulator) Cluster5280 0 1 0 0 0 1 0 ENC_44100(DNA sulfur modification protein DndB) t1925(putative bacteriophage protein) Cluster5281 0 1 1 0 0 0 0 ENC_44000(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4185(Prophage CP4-57 integrase,integrase) Cluster5282 0 1 0 1 0 0 0 ENC_43840(transcriptional regulator, IclR family) b0272(CP4-6 prophage; predicted DNA-binding transcriptional regulator) Cluster5283 1 1 0 0 0 0 0 ROD_32921(putative methyl-accepting chemotaxis protein II) ENC_43390(Methyl-accepting chemotaxis protein) Cluster5284 1 1 0 0 0 0 0 ROD_32781(putative oxidoreductase) ENC_43270(Predicted dehydrogenases and related proteins) Cluster5285 1 1 0 0 0 0 0 pseudoROD_32771(putative oxidoreductase (pseudogene)) ENC_43250(Predicted dehydrogenases and related proteins) Cluster5286 1 1 0 0 0 0 0 ROD_32751(putative oxidoreductase) ENC_43240(Predicted dehydrogenases and related proteins) Cluster5287 1 1 0 0 0 0 0 ROD_32641(methyl-accepting chemotaxis protein) ENC_43100(Methyl-accepting chemotaxis protein) Cluster5288 1 1 0 0 0 0 0 ROD_24511(extracellular metalloprotease) ENC_37570(Zinc metalloprotease (elastase)) Cluster5289 1 1 0 0 0 0 0 ROD_24521(conserved hypothetical protein) ENC_37560(hypothetical protein) Cluster5290 0 1 1 0 0 0 0 ENC_36670(Transposase and inactivated derivatives) Escherichia_coli_UPEC_ST131_v0.1_5_5104002-5133359.14(hypothetical protein) Cluster5291 0 1 1 0 0 0 0 ENC_36660(Transposase and inactivated derivatives) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4883(Transposase and inactivated derivatives,Integrase core domain) Cluster5292 0 1 1 0 0 0 0 ENC_36480(conjugative relaxase domain, TrwC/TraI family) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.60(Multifunctional conjugation protein TraI,conjugal transfer nickase/helicase TraI,conjugative transfer relaxase protein TraI,DNA helicase TraI) Cluster5293 0 1 1 0 0 0 0 ENC_36470(type IV conjugative transfer system coupling protein TraD) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.62(DNA transport protein TraD,conjugal transfer protein TraD,Type IV secretory pathway, VirD4 components,type IV conjugative transfer system coupling protein TraD,Type IV secretion-system coupling protein DNA-binding domain) Cluster5294 0 1 1 0 0 0 0 ENC_36430(Enterobacterial TraT complement resistance protein.) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.64(conjugal transfer surface exclusion protein TraT,Enterobacterial TraT complement resistance protein) Cluster5295 0 1 1 0 0 0 0 ENC_36410(TraG-like protein, N-terminal region.) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.66(conjugal transfer mating pair stabilization protein TraG,TraG-like protein, N-terminal region) Cluster5296 0 1 1 0 0 0 0 ENC_36400(Conjugative relaxosome accessory transposon protein.) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.67(conjugal transfer pilus assembly protein TraH,Conjugative relaxosome accessory transposon protein) Cluster5297 0 1 1 0 0 0 0 ENC_36370(type-F conjugative transfer system pilin assembly protein TraF) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.72(conjugal pilus assembly protein TraF,type-F conjugative transfer system pilin assembly protein TraF) Cluster5298 0 1 1 0 0 0 0 ENC_36360(Mating pair stabilisation protein TraN.) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.74(conjugal transfer mating pair stabilization protein TraN,type-F conjugative transfer system mating-pair stabilization protein TraN,Mating pair stabilisation protein TraN) Cluster5299 0 1 1 0 0 0 0 ENC_36350(type-F conjugative transfer system pilin assembly protein TrbC) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.75(conjugal transfer pilus assembly protein TrbC,type-F conjugative transfer system pilin assembly protein TrbC,Type-F conjugative transfer system pilin assembly protein) Cluster5300 0 1 1 0 0 0 0 ENC_36340(TraU protein.) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.77(conjugal transfer pilus assembly protein TraU,TraU protein) Cluster5301 0 2 0 0 0 0 0 ENC_36280(hypothetical protein),ENC_36290(hypothetical protein) Cluster5302 0 1 1 0 0 0 0 ENC_36250(type-IV secretion system protein TraC) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.86(hypothetical protein,conjugal transfer ATP-binding protein TraC,Type IV secretory pathway, VirB4 components,type-IV secretion system protein TraC,F pilus assembly Type-IV secretion system for plasmid transfer) Cluster5303 0 1 1 0 0 0 0 ENC_36230(type IV conjugative transfer system lipoprotein TraV) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.89(hypothetical protein,conjugal transfer protein TraV,type IV conjugative transfer system protein TraV,Type IV conjugative transfer system lipoprotein (TraV)) Cluster5304 0 1 1 0 0 0 0 ENC_36180(Bacterial conjugation TrbI-like protein.) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.93(conjugal transfer pilus assembly protein TraB,Bacterial conjugation TrbI-like protein) Cluster5305 0 1 1 0 0 0 0 ENC_36170(type-F conjugative transfer system secretin TraK) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.94(conjugal transfer protein TraK,type-F conjugative transfer system secretin TraK,TraK protein) Cluster5306 0 1 1 0 0 0 0 ENC_36160(TraE protein.) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.95(conjugal transfer pilus assembly protein TraE,type IV conjugative transfer system protein TraE,TraE protein) Cluster5307 0 1 1 0 0 0 0 ENC_36150(type IV conjugative transfer system protein TraL) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.96(conjugal transfer pilus assembly protein TraL,type IV conjugative transfer system protein TraL,TraL protein) Cluster5308 0 1 1 0 0 0 0 ENC_35880(PsiA protein.) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.105(plasmid SOS inhibition protein A,PsiA protein) Cluster5309 0 1 1 0 0 0 0 ENC_35870(Plasmid SOS inhibition protein (PsiB).) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.106(hypothetical protein,plasmid SOS inhibition protein B,Plasmid SOS inhibition protein (PsiB)) Cluster5310 0 1 1 0 0 0 0 ENC_35860(Predicted transcriptional regulators) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.107(Nucleoid occlusion protein,plasmid partitioning protein,PRTRC system ParB family protein,ParB-like nuclease domain) Cluster5311 0 1 1 0 0 0 0 ENC_35810(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.117(Protein of unknown function (DUF1380)) Cluster5312 0 1 1 0 0 0 0 ENC_35790(Protein of unknown function (DUF1380).) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.120(Protein of unknown function (DUF1380)) Cluster5313 0 1 1 0 0 0 0 ENC_35780(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.121(hypothetical protein) Cluster5314 0 1 0 0 0 0 1 ENC_35310(Plasmid stabilization system protein) SL1344_2935(putative DNA stabilisation protein) Cluster5315 1 1 0 0 0 0 0 ROD_35761(putative AraC-family transcriptional regulator) ENC_32650(AraC-type DNA-binding domain-containing proteins) Cluster5316 1 1 0 0 0 0 0 ROD_35751(conserved hypothetical protein) ENC_32640(Uncharacterized protein conserved in bacteria) Cluster5317 1 1 0 0 0 0 0 pseudoROD_35741(putative sugar transporter (pseudogene)) ENC_32630(oligosaccharide:H+ symporter) Cluster5318 1 1 0 0 0 0 0 ROD_35721(putative glycosyl hydrolase) ENC_32620(Glycosyl Hydrolase Family 88.) Cluster5319 0 1 0 0 0 0 1 ENC_32210(2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)) SL1344_0326(putative fumarylacetoacetate (faa) hydrolase) Cluster5320 0 1 0 1 0 0 0 ENC_32060(Uncharacterized protein conserved in bacteria) b1289(conserved protein) Cluster5321 0 1 0 1 0 0 0 ENC_31880(Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases) b2540(3-phenylpropionate dioxygenase, predicted ferredoxin subunit) Cluster5322 1 1 0 0 0 0 0 ROD_14011(conserved hypothetical protein) ENC_31830(Predicted ring-cleavage extradiol dioxygenase) Cluster5323 0 1 0 1 0 0 0 ENC_31820(Uncharacterized NAD(FAD)-dependent dehydrogenases) b2542(phenylpropionate dioxygenase, ferredoxin reductase subunit) Cluster5324 0 1 1 0 0 0 0 ENC_29030(Plasmid maintenance system killer protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3496(Toxin higB-1,Plasmid maintenance system killer protein,Plasmid maintenance system killer protein) Cluster5325 0 2 0 0 0 0 0 ENC_28840(SnoaL-like polyketide cyclase.),ENC_28850(SnoaL-like polyketide cyclase.) Cluster5326 0 1 1 0 0 0 0 ENC_27670(hypothetical protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2757(hypothetical protein) Cluster5327 1 1 0 0 0 0 0 ROD_43251(putative beta-ketoacyl synthase) ENC_26860(3-oxoacyl-(acyl-carrier-protein) synthase) Cluster5328 1 1 0 0 0 0 0 ROD_43261(putative short chain dehydrogenase) ENC_26850(3-oxoacyl-(acyl-carrier-protein) reductase, putative) Cluster5329 1 1 0 0 0 0 0 ROD_43271(putative dehydratase) ENC_26840(Predicted 3-hydroxylacyl-(acyl carrier protein) dehydratase) Cluster5330 1 1 0 0 0 0 0 ROD_43281(putative beta-ketoacyl synthase) ENC_26830(3-oxoacyl-(acyl-carrier-protein) synthase) Cluster5331 1 1 0 0 0 0 0 ROD_43291(putative lipoprotein) ENC_26820(Protein of unknown function (DUF3261).) Cluster5332 1 1 0 0 0 0 0 ROD_43301(putative membrane protein) ENC_26810(Predicted exporter) Cluster5333 1 1 0 0 0 0 0 ROD_43311(putative exported protein) ENC_26800(Outer membrane lipoprotein-sorting protein) Cluster5334 1 1 0 0 0 0 0 ROD_43361(putative outer membrane protein) ENC_26750(hypothetical protein) Cluster5335 1 1 0 0 0 0 0 ROD_43371(putative acyl carrier protein) ENC_26740(Acyl carrier protein) Cluster5336 1 1 0 0 0 0 0 ROD_43381(putative acyl carrier protein) ENC_26730(Acyl carrier protein) Cluster5337 1 1 0 0 0 0 0 ROD_43391(putative acyltransferase) ENC_26720(1-acyl-sn-glycerol-3-phosphate acyltransferase) Cluster5338 1 1 0 0 0 0 0 ROD_43401(conserved hypothetical protein) ENC_26710(hypothetical protein) Cluster5339 1 1 0 0 0 0 0 ROD_43501(2,3-diketo-L-gulonate TRAP transporter, small permease protein) ENC_26630(TRAP-type C4-dicarboxylate transport system, small permease component) Cluster5340 1 1 0 0 0 0 0 ROD_28431(putative ABC transporter periplasmic binding protein) ENC_23250(monosaccharide ABC transporter substrate-binding protein, CUT2 family (TC 3.A.1.2.-)) Cluster5341 1 1 0 0 0 0 0 ROD_28441(putative ABC transporter membrane protein) ENC_23240(monosaccharide ABC transporter membrane protein, CUT2 family (TC 3.A.1.2.-)) Cluster5342 0 1 1 0 0 0 0 ENC_21720(Uncharacterized protein conserved in bacteria) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2566(hypothetical protein,Uncharacterized BCR, COG1636) Cluster5343 1 1 0 0 0 0 0 ROD_02791(hypothetical prophage protein) ENC_17470(hypothetical protein) Cluster5344 0 2 0 0 0 0 0 ENC_17330(AP2 domain.),ENC_27440(AP2 domain.) Cluster5345 1 1 0 0 0 0 0 ROD_31672(putative anti-adapter protein IraM) ENC_15050(hypothetical protein) Cluster5346 0 1 0 1 0 0 0 ENC_14580(Transcriptional regulators) b2427(Repressor for murPQ, MurNAc 6-P inducible) Cluster5347 0 1 1 0 0 0 0 ENC_14000(TonB-dependent heme/hemoglobin receptor family protein/TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.192(Heme/hemopexin utilization protein C precursor,catecholate siderophore receptor CirA,ABC-type Fe3+-siderophore transport system, permease component,TonB-dependent heme/hemoglobin receptor family protein,TonB dependent receptor) Cluster5348 1 1 0 0 0 0 0 ROD_18191(conserved hypothetical protein) ENC_13870(hypothetical protein) Cluster5349 1 1 0 0 0 0 0 ROD_13941(conserved hypothetical protein) ENC_13470(hypothetical protein) Cluster5350 0 1 0 1 0 0 0 ENC_13320(hypothetical protein) b4602(hypothetical protein) Cluster5351 0 1 0 1 0 0 0 ENC_12790(hypothetical protein) b1551(Qin prophage; cold shock-induced protein) Cluster5352 0 1 0 0 0 1 0 ENC_12440(hypothetical protein) t3920(putative membrane protein) Cluster5353 1 1 0 0 0 0 0 ROD_14841(Major Facilitator Superfamily transporter) ENC_12020(Na+/melibiose symporter and related transporters) Cluster5354 1 1 0 0 0 0 0 ROD_12291(putative membrane protein) ENC_11540(hypothetical protein) Cluster5355 1 1 0 0 0 0 0 ROD_12301(hypothetical protein) ENC_11530(hypothetical protein) Cluster5356 0 2 0 0 0 0 0 ENC_11500(Uncharacterized protein conserved in bacteria),ENC_11510(Uncharacterized protein conserved in bacteria) Cluster5357 1 1 0 0 0 0 0 pseudoROD_22471(putative polygalacturonase (pseudogene)) ENC_10500(Endopolygalacturonase) Cluster5358 0 1 0 1 0 0 0 ENC_10090(ABC-type dipeptide transport system, periplasmic component) b1487(D-ala-D-a la transporter subunit) Cluster5359 0 1 0 1 0 0 0 ENC_10080(ABC-type dipeptide/oligopeptide/nickel transport systems, permease components) b1486(D-ala-D-ala transporter subunit) Cluster5360 0 1 0 1 0 0 0 ENC_10040(ABC-type oligopeptide transport system, ATPase component) b1483(D,D-dipeptide permease system, ATP-binding component) Cluster5361 0 1 0 1 0 0 0 ENC_06090(Methyl-accepting chemotaxis protein) b1885(methyl-accepting protein IV) Cluster5362 1 1 0 0 0 0 0 ROD_19351(putative fimbrial usher protein) ENC_06050(P pilus assembly protein, porin PapC) Cluster5363 1 1 0 0 0 0 0 ROD_19361(putative fimbrial chaperone protein) ENC_06040(P pilus assembly protein, chaperone PapD) Cluster5364 1 1 0 0 0 0 0 ROD_19371(putative fimbrial subunit) ENC_06030(Uncharacterized secreted protein) Cluster5365 1 1 0 0 0 0 0 ROD_19381(putative fimbrial subunit) ENC_06020(Spore Coat Protein U domain.) Cluster5366 0 1 1 0 0 0 0 ENC_05130(ABC-type sugar transport system, auxiliary component) Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.29(ABC-type sugar transport system, auxiliary component,Protein of unknown function (DUF1498)) Cluster5367 1 1 0 0 0 0 0 ROD_03731(putative response regulator) ENC_03300(Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain) Cluster5368 0 0 0 0 2 0 0 BN373_p02281(conserved hypothetical protein),BN373_p02301(conserved hypothetical protein) Cluster5369 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4157(hypothetical protein) BN373_p02191(conserved hypothetical protein) Cluster5370 0 0 0 0 2 0 0 BN373_p01981(conserved hypothetical protein),BN373_p01991(conserved hypothetical protein) Cluster5371 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1736(Transposase and inactivated derivatives,Integrase core domain) BN373_p01831(putative transposase) Cluster5372 0 1 0 0 1 0 0 ENC_35670(Initiator Replication protein.) BN373_p01751(RepA/RepC) Cluster5373 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.125(Sporulation initiation inhibitor protein soj,plasmid-partitioning protein SopA,Septum formation inhibitor-activating ATPase,plasmid partitioning protein RepA,CobQ/CobB/MinD/ParA nucleotide binding domain) BN373_p01741(plasmid-partitioning protein SopA) Cluster5374 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_8_5316109-5358439.9(hypothetical protein) BN373_p01661(transposase) Cluster5375 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.54(Thermonuclease precursor,Staphylococcal nuclease homologue) BN373_p01241(putative nuclease) Cluster5376 0 1 0 0 1 0 0 ENC_35290(hypothetical protein) BN373_p00821(conserved hypothetical protein) Cluster5377 0 1 0 0 1 0 0 ENC_35370(Putative copper export protein) BN373_p00741(copper resistance protein D) Cluster5378 0 1 0 0 1 0 0 ENC_35390(Uncharacterized protein involved in copper resistance) BN373_p00721(copper resistance protein B) Cluster5379 0 1 0 0 1 0 0 ENC_35400(copper-resistance protein, CopA family) BN373_p00711(copper resistant protein PcoA) Cluster5380 0 1 0 0 1 0 0 ENC_35410(hypothetical protein) BN373_p00701(copper resistant protein PcoE) Cluster5381 0 1 0 0 1 0 0 ENC_35420(Membrane proteins related to metalloendopeptidases) BN373_p00681(conserved hypothetical protein) Cluster5382 0 1 0 0 1 0 0 ENC_35430(Protein of unknown function (DUF2933).) BN373_p00671(conserved hypothetical protein) Cluster5383 0 1 0 0 1 0 0 ENC_35470(Predicted metal-binding protein) BN373_p00651(conserved hypothetical protein) Cluster5384 0 0 0 1 1 0 0 b1159(e14 prophage; 5-methylcytosine-specific restriction endonuclease B) BN373_p00551(HNH endonuclease) Cluster5385 0 0 0 0 2 0 0 BN373_p00411(conserved hypothetical protein),BN373_p00991(conserved hypothetical protein) Cluster5386 0 0 0 0 2 0 0 BN373_p00371(conserved hypothetical protein),BN373_p01091(conserved hypothetical protein) Cluster5387 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.762(Aerobactin synthase IucC,IucA / IucC family) BN373_p00311(IucC) Cluster5388 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.768(hypothetical protein,Protein of unknown function (DUF1471)) BN373_p00281(conserved hypothetical protein) Cluster5389 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.767(Bacterial regulatory proteins, tetR family) BN373_p00271(conserved hypothetical protein) Cluster5390 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.766(Predicted membrane protein,Protein of unknown function, DUF417) BN373_p00261(conserved hypothetical protein) Cluster5391 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.131(Protein of unknown function (DUF3800)) BN373_p00151(conserved hypothetical protein) Cluster5392 0 1 0 0 1 0 0 ENC_03890(NADPH:quinone reductase and related Zn-dependent oxidoreductases) BN373_p00041(conserved hypothetical protein) Cluster5393 0 0 0 0 2 0 0 BN373_misc_RNA00356(RtT),BN373_misc_RNA00359(RtT) Cluster5394 0 0 0 0 2 0 0 BN373_misc_RNA00171(cspA.3),BN373_misc_RNA00371(cspA.2) Cluster5395 0 0 0 0 2 0 0 BN373_misc_RNA00051(isrN.2),BN373_misc_RNA00211(isrN.3) Cluster5396 0 1 0 0 1 0 0 ENC_01350(diguanylate cyclase (GGDEF) domain) BN373_49851(diguanylate cyclase) Cluster5397 0 1 0 0 1 0 0 ENC_01360(Phosphotransferase system cellobiose-specific component IIB) BN373_49841(PTS system, lactose/cellobiose specific IIB subunit) Cluster5398 0 1 0 0 1 0 0 ENC_01370(Phosphotransferase system cellobiose-specific component IIA) BN373_49831(PTS system, lactose/cellobiose specific IIA subunit) Cluster5399 0 0 0 0 2 0 0 BN373_48881(conserved hypothetical protein),BN373_misc_RNA00811(Cobalamin.2) Cluster5400 0 1 0 0 1 0 0 ENC_00620(rhamnose-binding protein) BN373_48431(rhamnose ABC transporter, periplasmic rhamnose-binding protein) Cluster5401 0 1 0 0 1 0 0 ENC_00610(rhamnose ABC transporter ATP-binding protein) BN373_48421(rhamnose ABC transporter, ATP-binding protein) Cluster5402 0 1 0 0 1 0 0 ENC_00600(rhamnose ABC transporter membrane protein) BN373_48411(rhamnose ABC transporter, permease protein) Cluster5403 0 1 0 0 1 0 0 ENC_00590(monosaccharide ABC transporter membrane protein, CUT2 family (TC 3.A.1.2.-)) BN373_48401(rhamnose ABC transporter, permease protein) Cluster5404 0 1 0 0 1 0 0 ENC_00560(oligosaccharide:H+ symporter) BN373_48371(raffinose permease) Cluster5405 0 1 0 0 1 0 0 ENC_00550(Alpha-galactosidase) BN373_48361(alpha-galactosidase) Cluster5406 0 1 0 0 1 0 0 ENC_00540(transcriptional regulator, LacI family) BN373_48351(HTH-type transcriptional regulator RafR) Cluster5407 0 0 0 0 1 1 0 BN373_47441(conserved hypothetical protein) t3689(hypothetical protein) Cluster5408 0 0 0 0 1 1 0 BN373_47431(outer membrane protein, OMP85 family) t3690(hypothetical protein) Cluster5409 0 0 0 1 1 0 0 b3645(DNA-damage-inducible protein) BN373_47331(putative dna-damage-inducible protein) Cluster5410 0 1 0 0 1 0 0 ENC_03650(Acetyltransferase (GNAT) family.) BN373_47201(acetyltransferase, GNAT family) Cluster5411 1 0 0 0 1 0 0 ROD_31611(Major Facilitator Superfamily transporter) BN373_46951(putative 4-hydroxybenzoate transporter) Cluster5412 1 0 0 0 1 0 0 ROD_31621(putative extradiol dioxygenase) BN373_46941(protocatechuate 4,5-dioxygenase, alpha subunit) Cluster5413 1 0 0 0 1 0 0 ROD_31631(putative LysR-family transcriptional regulator) BN373_46931(transcriptional regulator, LysR family) Cluster5414 1 0 0 0 1 0 0 ROD_31641(putative DNA binding protein) BN373_46921(GlcNAc-PI de-N-acetylase family protein) Cluster5415 1 0 0 0 1 0 0 ROD_31651(putative methyl transferase) BN373_46911(4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase) Cluster5416 1 0 0 0 1 0 0 ROD_31671(putative dehydrodgenase) BN373_46891(putative oxidoreductase, NAD-binding) Cluster5417 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2473(Multidrug resistance protein mexA precursor,multidrug efflux system transporter AcrA,efflux transporter, RND family, MFP subunit,HlyD family secretion protein) BN373_46811(multidrug efflux transporter EefA) Cluster5418 0 1 0 0 1 0 0 ENC_03350(transcriptional regulator, TetR family) BN373_46791(transcriptional regulator, TetR family) Cluster5419 0 1 0 0 1 0 0 ENC_03340(drug resistance transporter, EmrB/QacA subfamily) BN373_46781(drug resistance MFS transporter, drug:H+ antiporter-1 (DHA2) family) Cluster5420 0 1 0 0 1 0 0 ENC_36000(alkylhydroperoxidase AhpD family core domain) BN373_46741(putative peroxidase) Cluster5421 0 1 0 0 1 0 0 ENC_10490(NUDIX domain.) BN373_46701(putative ADP-ribose pyrophosphatase) Cluster5422 1 0 0 0 1 0 0 ROD_04021(conserved hypothetical protein) BN373_46691(conserved hypothetical protein) Cluster5423 0 1 0 0 1 0 0 ENC_45130(zinc-binding alcohol dehydrogenase family protein) BN373_46641(zinc-binding alcohol dehydrogenase family protein) Cluster5424 0 1 0 0 1 0 0 ENC_37340(Transcriptional regulators) BN373_46591(transcriptional regulator, RpiR family) Cluster5425 0 1 0 0 1 0 0 ENC_02520(Glycosyltransferases involved in cell wall biogenesis) BN373_46161(glycosyl transferase, group 2 family protein) Cluster5426 0 1 0 0 1 0 0 ENC_02490(Glycosyltransferase) BN373_46131(glycosyl transferase, group 1 family protein) Cluster5427 0 1 0 0 1 0 0 ENC_02480(Glycosyltransferase) BN373_46121(putative lipopolysaccharide core biosynthesis protein RfaG) Cluster5428 0 1 0 0 1 0 0 ENC_02330(hypothetical protein) BN373_46011(glycosyl transferase, group 2 family protein) Cluster5429 0 1 0 0 1 0 0 ENC_01680(ATPase components of ABC transporters with duplicated ATPase domains) BN373_45561(ABC transporter, ATP-binding protein) Cluster5430 0 1 0 0 1 0 0 ENC_01610(hypothetical protein) BN373_45481(AP endonuclease, family 2) Cluster5431 0 1 0 0 1 0 0 ENC_01600(Transcriptional regulators) BN373_45471(sugar binding transcriptional regulator, LacI family) Cluster5432 0 1 0 0 1 0 0 ENC_27170(Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)) BN373_45071(oxidoreductase, short chain dehydrogenase/reductase family) Cluster5433 0 1 0 0 1 0 0 ENC_27140(Acetyltransferases, including N-acetylases of ribosomal proteins) BN373_45061(acetyltransferase, GNAT family) Cluster5434 0 0 0 0 1 0 1 BN373_45001(PAP2 family protein) SL1344_3560(putative phosphatase) Cluster5435 0 1 0 0 1 0 0 ENC_16490(Mg/Co/Ni transporter MgtE (contains CBS domain)) BN373_44921(divalent cation transporter, MgtE family) Cluster5436 1 0 0 0 1 0 0 ROD_43151(conserved hypothetical protein) BN373_44911(hypothetical protein) Cluster5437 1 0 0 0 1 0 0 ROD_43621(GntR-family transcriptional regulator) BN373_44611(transcriptional regulator, GntR family/aminotransferase family protein) Cluster5438 1 0 0 0 1 0 0 ROD_43641(putative membrane protein) BN373_44591(tryptophan/tyrosine permease family protein) Cluster5439 1 0 0 0 1 0 0 ROD_05631(putative inner membrane DNA-binding protein) BN373_44431(Ccm domain protein) Cluster5440 0 1 0 0 1 0 0 ENC_25880(hypothetical protein) BN373_43991(hypothetical protein) Cluster5441 0 1 0 0 1 0 0 ENC_35020(3-dehydroquinate dehydratase) BN373_43041(3-dehydroquinate dehydratase, type II) Cluster5442 1 0 0 0 1 0 0 ROD_46091(putative mannonate dehydratase) BN373_42701(putative mannonate dehydratase) Cluster5443 0 1 0 0 1 0 0 ENC_31150(hypothetical protein) BN373_42321(conserved hypothetical protein) Cluster5444 0 1 0 0 1 0 0 ENC_34560(dihydroxyacetone kinase, ATP-dependent) BN373_41521(dihydroxyacetone kinase) Cluster5445 0 1 0 0 1 0 0 ENC_29070(Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)) BN373_40681(oxidoreductase, short chain dehydrogenase/reductase family) Cluster5446 0 1 0 0 1 0 0 ENC_29060(transcriptional regulator, LysR family) BN373_40671(transcriptional regulator, LysR family) Cluster5447 0 1 0 0 1 0 0 ENC_13590(cystathionine beta-synthase) BN373_40651(putative cystathionine beta-synthase) Cluster5448 0 0 0 0 2 0 0 BN373_40601(putative fimbrial chaperone),BN373_40631(putative fimbrial chaperone) Cluster5449 0 1 0 0 1 0 0 ENC_31370(Transcriptional regulators) BN373_39961(transcriptional regulator, RpiR family) Cluster5450 0 1 0 0 1 0 0 ENC_10420(Arabinose efflux permease) BN373_39821(transporter, major facilitator family) Cluster5451 0 1 0 0 1 0 0 ENC_10430(transcriptional regulator, LysR family) BN373_39811(transcriptional regulator, LysR family) Cluster5452 0 0 0 0 2 0 0 BN373_39761(hypothetical protein),BN373_39771(hypothetical protein) Cluster5453 1 0 0 0 1 0 0 ROD_29191(fimbrial adhesin FimK) BN373_39261(putative cyclic diguanylate phosphodiesterase) Cluster5454 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.42(Uncharacterized inner membrane transporter yedA,putative DMT superfamily transporter inner membrane protein,Predicted permease, DMT superfamily,carboxylate/amino acid/amine transporter,EamA-like transporter family) BN373_39131(putative membrane protein) Cluster5455 0 0 0 0 2 0 0 BN373_39071(fimbrial protein),BN373_39111(mrkF protein) Cluster5456 0 1 0 0 1 0 0 ENC_30750(Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosid ase) BN373_38801(glycosyl hydrolase, family 1) Cluster5457 0 0 0 0 2 0 0 BN373_37801(hypothetical protein),BN373_misc_RNA00551(CsrB.1) Cluster5458 0 0 0 0 2 0 0 BN373_37661(NAD dependent epimerase/dehydratase family),BN373_39441(L-aminoadipate-semialdehyde dehydrogenase large subunit) Cluster5459 0 0 0 0 1 0 1 BN373_37311(conserved hypothetical protein) SL1344_2728(conserved hypothetical protein) Cluster5460 0 0 0 0 1 0 1 BN373_37301(conserved hypothetical protein) SL1344_2725(conserved hypothetical protein) Cluster5461 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.28(Fructokinase,fructokinase,Predicted phosphosugar isomerases,ROK family protein (putative glucokinase),ROK family) BN373_37091(ROK family protein) Cluster5462 0 0 0 0 1 0 1 BN373_36801(high-affinity nickel transport protein) SL1344_2767(putative cation transporter) Cluster5463 0 1 0 0 1 0 0 ENC_29480(ABC-type Mn/Zn transport systems, ATPase component) BN373_36681(cation ABC transporter, ATP-binding protein) Cluster5464 0 1 0 0 1 0 0 ENC_29470(ABC-type Mn2+/Zn2+ transport systems, permease components) BN373_36671(cation ABC transporter, permease protein) Cluster5465 0 1 0 0 1 0 0 ENC_29340(Isopropylmalate/homocitrate/citramalate synthases) BN373_36541(2-isopropylmalate synthase) Cluster5466 0 1 0 0 1 0 0 ENC_03900(transcriptional regulator, LysR family) BN373_36291(transcriptional regulator, LysR family) Cluster5467 0 1 0 0 1 0 0 ENC_47670(P pilus assembly protein, pilin FimA) BN373_36231(fimbrial protein) Cluster5468 0 1 0 0 1 0 0 ENC_11220(hypothetical protein) BN373_36191(putative membrane protein) Cluster5469 0 1 0 0 1 0 0 ENC_26970(Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)) BN373_36181(oxidoreductase, short chain dehydrogenase/reductase family) Cluster5470 0 1 0 0 1 0 0 ENC_37660(transcriptional regulator, BadM/Rrf2 family) BN373_36091(putative transcriptional regulator) Cluster5471 0 1 0 0 1 0 0 ENC_37620(transcriptional regulator, AraC family) BN373_36061(transcriptional regulator, AraC family) Cluster5472 0 1 0 0 1 0 0 ENC_28030(Uncharacterized iron-regulated membrane protein) BN373_35811(PepSY-associated membrane protein) Cluster5473 0 0 0 0 2 0 0 BN373_35101(putative membrane protein),BN373_35231(putative membrane protein) Cluster5474 0 1 0 0 1 0 0 ENC_37540(Predicted dehydrogenases and related proteins) BN373_34971(oxidoreductase, NAD-binding) Cluster5475 0 0 0 1 1 0 0 b0341(predicted cyanate transporter) BN373_33981(putative cyanate transporter) Cluster5476 0 0 0 1 1 0 0 b0338(transcriptional activator of cyn operon; autorepressor) BN373_33961(DNA-binding transcriptional regulator CynR) Cluster5477 0 0 0 0 1 0 1 BN373_33931(hypothetical protein) SL1344_2600(bacteriophage integrase) Cluster5478 0 0 0 0 1 0 1 BN373_33911(conserved hypothetical protein) SL1344_2587(predicted bacteriophage protein) Cluster5479 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1927(hypothetical protein) BN373_33881(conserved hypothetical protein) Cluster5480 0 0 0 1 1 0 0 b1148(e14 prophage; predicted protein) BN373_33821(conserved hypothetical protein) Cluster5481 0 0 0 0 1 1 0 BN373_33801(dna adenine methylase) t1926(putative DNA methylase) Cluster5482 0 0 0 0 1 0 1 BN373_33651(sb1) SL1344_1951(predicted bacteriophage protein) Cluster5483 0 0 0 0 1 0 1 BN373_33621(phage prohead protease, hk97 family) SL1344_1948(putative peptidase) Cluster5484 0 0 0 0 1 0 1 BN373_33601(conserved hypothetical protein) SL1344_1946(predicted bacteriophage protein) Cluster5485 0 0 0 0 2 0 0 BN373_33521(conserved hypothetical protein),BN373_33541(conserved hypothetical protein) Cluster5486 0 0 0 0 2 0 0 BN373_33511(conserved hypothetical protein),BN373_33531(conserved hypothetical protein) Cluster5487 1 0 0 0 1 0 0 ROD_23421(putative membrane transport protein) BN373_32351(inorganic anion transporter, sulfate permease (SulP) family) Cluster5488 1 0 0 0 1 0 0 ROD_10571(putative outer membrane protein) BN373_32321(putative membrane protein) Cluster5489 0 1 0 0 1 0 0 ENC_41920(Beta-lactamase class C and other penicillin binding proteins) BN373_32261(beta-lactamase) Cluster5490 0 0 0 0 1 1 0 BN373_32061(conserved hypothetical protein) t0349(conserved hypothetical protein) Cluster5491 1 0 0 0 1 0 0 ROD_03491(putative porin) BN373_31821(carbohydrate-selective porin, OprB family) Cluster5492 0 1 0 0 1 0 0 ENC_40470(Acetyltransferases) BN373_31611(acetyltransferase, GNAT family) Cluster5493 0 1 0 0 1 0 0 ENC_40710(Mannitol-1-phosphate/altronate dehydrogenases) BN373_31461(D-arabinitol 4-dehydrogenase) Cluster5494 0 1 0 0 1 0 0 ENC_40720(D-xylulose kinase) BN373_31451(xylulokinase) Cluster5495 0 1 0 0 1 0 0 ENC_40750(haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E) BN373_31431(HAD hydrolase, family IA) Cluster5496 1 0 0 0 1 0 0 ROD_22191(ABC transporter permease protein) BN373_31401(ABC transporter, permease protein) Cluster5497 0 0 0 0 2 0 0 BN373_30881(unknown),BN373_30891(conserved hypothetical protein) Cluster5498 0 1 0 0 1 0 0 ENC_09680(transcriptional regulator, ArsR family) BN373_30731(putative transcriptional regulator) Cluster5499 0 1 0 0 1 0 0 ENC_24030(Uncharacterized protein conserved in bacteria) BN373_30586(oxidoreductase,Oxidoreductase molybdopterin binding domain) Cluster5500 0 1 0 0 1 0 0 ENC_24040(diguanylate cyclase/phosphodiesterase) BN373_30571(diguanylate cyclase/cyclic diguanylate phosphodiesterase) Cluster5501 0 1 0 0 1 0 0 ENC_10650(diguanylate cyclase with GAF sensor) BN373_30511(GAF domain/diguanylate cyclase (GGDEF) domain protein) Cluster5502 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1775(Protein of unknown function (DUF3442)) BN373_30371(conserved hypothetical protein) Cluster5503 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4164(HTH-type transcriptional repressor nemR,DNA-binding transcriptional repressor AcrR,pyrimidine utilization regulatory protein R,Bacterial regulatory proteins, tetR family) BN373_30221(transcriptional regulator, TetR family) Cluster5504 1 0 0 0 1 0 0 ROD_25161(conserved hypothetical protein) BN373_29921(dihydrodipicolinate synthase) Cluster5505 0 1 0 0 1 0 0 ENC_05750(amino acid/amide ABC transporter substrate-binding protein, HAAT family (TC 3.A.1.4.-)) BN373_28701(hydrophobic amino acid ABC transporter, periplasmic amino acid-binding protein) Cluster5506 0 1 0 0 1 0 0 ENC_05740(amino acid/amide ABC transporter membrane protein 1, HAAT family (TC 3.A.1.4.-)) BN373_28691(hydrophobic amino acid ABC transporter, permease protein) Cluster5507 0 1 0 0 1 0 0 ENC_05730(amino acid/amide ABC transporter membrane protein 2, HAAT family (TC 3.A.1.4.-)) BN373_28681(hydrophobic amino acid ABC transporter, permease protein) Cluster5508 0 1 0 0 1 0 0 ENC_05720(amino acid/amide ABC transporter ATP-binding protein 1, HAAT family (TC 3.A.1.4.-)) BN373_28671(hydrophobic amino acid ABC transporter, ATP-binding protein) Cluster5509 0 1 0 0 1 0 0 ENC_41900(ABC-type molybdate transport system, periplasmic component) BN373_28601(ABC transporter, periplasmic substrate-binding protein) Cluster5510 0 1 0 0 1 0 0 ENC_11450(Pseudouridylate synthases, 23S RNA-specific) BN373_28571(pseudouridine synthase, RluA family) Cluster5511 1 0 0 0 1 0 0 ROD_34221(T6SS protein Cts2R) BN373_28431(type VI secretion protein, VC_A0111 family) Cluster5512 0 0 0 1 1 0 0 b0544(DLP12 prophage; predicted recombinase) BN373_27731(site-specific recombinase, resolvase family) Cluster5513 0 1 0 0 1 0 0 ENC_11470(Domain of unknown function (DUF1852).) BN373_27401(conserved hypothetical protein) Cluster5514 0 1 0 0 1 0 0 ENC_11480(methionine synthase (B12-independent)) BN373_27391(cobalamine-independent methonine synthase) Cluster5515 0 0 0 0 2 0 0 BN373_27381(transporter, major facilitator family),BN373_p01161(putative permease protein) Cluster5516 0 1 0 0 1 0 0 ENC_16540(ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components) BN373_27371(iron ABC transporter, ATP-binding protein) Cluster5517 0 1 0 0 1 0 0 ENC_16530(ABC-type Fe3+-siderophore transport system, permease component) BN373_27361(iron ABC transporter, permease protein) Cluster5518 0 1 0 0 1 0 0 ENC_16520(ABC-type Fe3+-hydroxamate transport system, periplasmic component) BN373_27351(iron ABC transporter, periplasmic iron-binding protein) Cluster5519 0 1 0 0 1 0 0 ENC_09220(hypothetical protein) BN373_27266(signal peptide protein) Cluster5520 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2684(Uncharacterized ABC transporter ATP-binding protein HI_1470,hemin importer ATP-binding subunit,ABC-type phosphate/phosphonate transport system, ATPase component,proposed F420-0 ABC transporter, ATP-binding protein,ABC transporter) BN373_27111(iron chelate ABC transporter, ATP-binding protein) Cluster5521 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2683(Probable ABC transporter permease protein HI_1471,corrinoid ABC transporter permease,ABC-type Fe3+-siderophore transport system, permease component,proposed F420-0 ABC transporter, permease protein,FecCD transport family) BN373_27101(iron chelate ABC transporter, permease protein) Cluster5522 0 0 0 0 2 0 0 BN373_26951(acyl-CoA dehydrogenase family protein),BN373_37871(conserved hypothetical protein) Cluster5523 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.668(Probable siderophore transport system ATP-binding protein YusV,iron-dicitrate transporter ATP-binding subunit,ABC-type enterochelin transport system, ATPase component,proposed F420-0 ABC transporter, ATP-binding protein,ABC transporter) BN373_26891(iron ABC transporter, ATP-binding protein) Cluster5524 1 0 0 0 1 0 0 ROD_27911(putative periplasmic solute-binding protein of ABC transporter) BN373_26841(amino acid ABC transporter, periplasmic amino acid-binding protein) Cluster5525 1 0 0 0 1 0 0 ROD_27901(putative membrane component of ABC transporter) BN373_26831(amino acid ABC transporter, permease protein) Cluster5526 1 0 0 0 1 0 0 ROD_27891(putative ATP-binding protein of ABC transporter) BN373_26821(amino acid ABC transporter, ATP-binding protein) Cluster5527 1 0 0 0 1 0 0 ROD_10561(putative gluconate dehydrogenase subunit) BN373_26691(gluconate 2-dehydrogenase, subunit 3) Cluster5528 1 0 0 0 1 0 0 ROD_10551(putative gluconate dehydrogenase subunit) BN373_26681(gluconate 2-dehydrogenase, flavoprotein subunit) Cluster5529 1 0 0 0 1 0 0 ROD_10541(putative gluconate dehydrogenase subunit) BN373_26671(gluconate 2-dehydrogenase, cytochrome c subunit) Cluster5530 0 1 0 0 1 0 0 ENC_21670(acetoin reductases) BN373_26501(acetoin dehydrogenase) Cluster5531 0 1 0 0 1 0 0 ENC_21710(transcriptional regulator, LysR family) BN373_26471(putative transcriptional regulator BudR) Cluster5532 1 0 0 0 1 0 0 ROD_15521(putative short chain dehydrogenase) BN373_26461(3-hydroxybutyrate dehydrogenase) Cluster5533 1 0 0 0 1 0 0 pseudoROD_15501(putative CoA-transferase beta subunit (fragment)) BN373_26421(putative acetyl-CoA:acetoacetyl-CoA transferase beta subunit) Cluster5534 1 0 0 0 1 0 0 ROD_15481(putative LysR-family transcriptional regulator) BN373_26401(transcriptional regulator, LysR family) Cluster5535 0 1 0 0 1 0 0 ENC_13480(hypothetical protein) BN373_26391(conserved hypothetical protein) Cluster5536 1 0 0 0 1 0 0 ROD_15291(conserved hypothetical protein) BN373_26271(creatininase) Cluster5537 0 0 0 0 2 0 0 BN373_26211(ABC transporter, periplasmic substrate-binding protein),BN373_26281(ABC transporter, periplasmic substrate-binding protein) Cluster5538 0 1 0 0 1 0 0 ENC_12200(Chloramphenicol O-acetyltransferase) BN373_26021(chloramphenicol O-acetyltransferase) Cluster5539 0 1 0 0 1 0 0 ENC_44330(Lactoylglutathione lyase and related lyases) BN373_26011(glyoxalase family protein) Cluster5540 1 0 0 0 1 0 0 ROD_42351(putative membrane protein) BN373_25941(conserved hypothetical protein) Cluster5541 1 0 0 0 1 0 0 ROD_27601(conserved hypothetical protein) BN373_25911(conserved hypothetical protein) Cluster5542 1 0 0 0 1 0 0 ROD_27591(LysR-family transcriptional regulator) BN373_25901(transcriptional regulator, LysR family) Cluster5543 1 0 0 0 1 0 0 ROD_16141(protocatechuate 3,4-dioxygenase alpha chain) BN373_25301(protocatechuate 3,4-dioxygenase, alpha subunit) Cluster5544 1 0 0 0 1 0 0 ROD_16131(putative protocatechuate 3,4-dioxygenase beta chain) BN373_25291(protocatechuate 3,4-dioxygenase, beta subunit) Cluster5545 1 0 0 0 1 0 0 ROD_16021(putative inner membrane protein) BN373_25191(putative membrane protein) Cluster5546 0 1 0 0 1 0 0 ENC_09280(Protein of unknown function (DUF2474).) BN373_25111(conserved hypothetical protein) Cluster5547 0 1 0 0 1 0 0 ENC_09360(Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)) BN373_24961(putative hydrolase) Cluster5548 0 1 0 0 1 0 0 ENC_09570(amidohydrolase) BN373_24781(amidohydrolase family protein) Cluster5549 0 1 0 0 1 0 0 ENC_09580(Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases) BN373_24771(Ytnj protein) Cluster5550 0 1 0 0 1 0 0 ENC_09590(amino acid ABC transporter substrate-binding protein, PAAT family (TC 3.A.1.3.-)) BN373_24761(ABC transporter, periplasmic substrate-binding protein) Cluster5551 0 1 0 0 1 0 0 ENC_09600(Acetyltransferase (GNAT) family.) BN373_24751(acetyltransferase, GNAT family) Cluster5552 0 1 0 0 1 0 0 ENC_09610(amino acid ABC transporter membrane protein, PAAT family (TC 3.A.1.3.-)) BN373_24741(amino acid ABC transporter, permease protein) Cluster5553 0 0 0 1 1 0 0 b2538(3-phenylpropionate dioxygenase, large (alpha) subunit) BN373_24531(2-chlorobenzoate 1,2-dioxygenase, alpha subunit) Cluster5554 0 0 0 1 1 0 0 b2539(3-phenylpropionate dioxygenase, small (beta) subunit) BN373_24521(2-chlorobenzoate 1,2-dioxygenase, beta subunit) Cluster5555 0 1 0 0 1 0 0 ENC_09820(Anaerobic dehydrogenases, typically selenocysteine-containing) BN373_24481(formate dehydrogenase, nitrate inducible, alpha subunit, selenocysteine-containing) Cluster5556 0 1 0 0 1 0 0 ENC_09870(CcdB protein.) BN373_24441(conserved hypothetical protein) Cluster5557 0 1 0 0 1 0 0 ENC_09880(Uncharacterized conserved protein) BN373_24421(putative polyphosphate kinase) Cluster5558 1 0 0 0 1 0 0 ROD_15591(putative inorganic pyrophosphatase) BN373_24321(inorganic diphosphatase) Cluster5559 1 0 0 0 1 0 0 ROD_27551(putative MarR-family transcriptional regulator) BN373_24311(transcriptional regulator, MarR family/acetyltransferase, GNAT family) Cluster5560 0 0 0 0 2 0 0 BN373_24286(glycosyltransferase),BN373_24291(hypothetical protein) Cluster5561 0 1 0 0 1 0 0 ENC_09990(Zn-dependent hydrolases, including glyoxylases) BN373_24261(metallo-beta-lactamase family protein) Cluster5562 0 1 0 0 1 0 0 ENC_10000(transcriptional regulator, LysR family) BN373_24251(LysR family transcriptional regulator) Cluster5563 0 1 0 0 1 0 0 ENC_27090(hypothetical protein) BN373_24201(conserved hypothetical protein) Cluster5564 0 1 0 0 1 0 0 ENC_31050(Glycosidases) BN373_24171(putative trehalose synthase) Cluster5565 1 0 0 0 1 0 0 ROD_12441(hypothetical protein) BN373_24081(conserved hypothetical protein) Cluster5566 0 1 0 0 1 0 0 ENC_12510(Coenzyme PQQ synthesis protein D (PqqD).) BN373_23921(coenzyme PQQ synthesis protein D) Cluster5567 0 1 0 0 1 0 0 ENC_12480(coenzyme PQQ biosynthesis protein B) BN373_23901(coenzyme PQQ biosynthesis protein B) Cluster5568 0 1 0 0 1 0 0 ENC_12470(coenzyme PQQ biosynthesis protein A) BN373_23891(coenzyme PQQ biosynthesis protein A) Cluster5569 0 1 0 0 1 0 0 ENC_12460(dipeptidase AC. Metallo peptidase. MEROPS family M19) BN373_23881(renal dipeptidase family protein) Cluster5570 0 1 0 0 1 0 0 ENC_10550(Signal transduction histidine kinase) BN373_23851(sensor histidine kinase) Cluster5571 0 1 0 0 1 0 0 ENC_10540(Cytochrome c biogenesis protein) BN373_23841(cytochrome c biogenesis protein/redoxin) Cluster5572 0 1 0 0 1 0 0 ENC_40540(diaminobutyrate aminotransferase apoenzyme) BN373_23791(diaminobutyrate--2-oxoglutarate aminotransferase) Cluster5573 0 0 0 0 1 1 0 BN373_23731(conserved hypothetical protein) t3691(hypothetical protein) Cluster5574 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3480(Secreted protein hcp,Hemolysin-coregulated protein (uncharacterized),type VI secretion system effector, Hcp1 family,Uncharacterized conserved protein (DUF2235)) BN373_23671(conserved hypothetical protein) Cluster5575 0 1 0 0 1 0 0 ENC_28910(Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)) BN373_23571(conserved hypothetical protein) Cluster5576 0 0 0 0 1 0 1 BN373_23531(conserved hypothetical protein) SL1344_4121(conserved hypothetical protein) Cluster5577 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.2427(Multidrug resistance protein B,putative transporter,Arabinose efflux permease,drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family,Major Facilitator Superfamily) BN373_23511(drug resistance MFS transporter, drug:H+ antiporter-1 (DHA2) family) Cluster5578 0 1 0 0 1 0 0 ENC_28820(Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases) BN373_23451(amidohydrolase, AtzE family) Cluster5579 0 1 0 0 1 0 0 ENC_24720(gamma-glutamyltransferase 2. Threonine peptidase. MEROPS family T03) BN373_23431(putative gamma-glutamyltransferase) Cluster5580 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.23(EIIABC-Fru,PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC,PTS system, fructose subfamily, IIA component,Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2) BN373_23191(fructose-mannitol-specific PTS family enzyme IIA component) Cluster5581 0 0 0 0 2 0 0 BN373_23071(ABC transporter, ATP-binding protein),BN373_40441(galactoside transport ATP-binding protein) Cluster5582 0 0 0 1 1 0 0 b0900(predicted DNA-binding transcriptional regulator) BN373_22941(LysR family transcriptional regulator) Cluster5583 0 0 0 0 2 0 0 BN373_22641(PTS system, glucose-like IIBC component),BN373_46571(PTS system, IIBC component) Cluster5584 0 0 0 0 2 0 0 BN373_22421(transcriptional regulator, LysR family),BN373_26221(transcriptional regulator, LysR family) Cluster5585 0 1 0 0 1 0 0 ENC_31860(Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit) BN373_22411(Rieske 2Fe-2S domain protein) Cluster5586 0 0 0 0 2 0 0 BN373_22401(putative vanillate O-demethylase oxidoreductase),BN373_26241(vanillate O-demethylase oxidoreductase) Cluster5587 0 1 0 0 1 0 0 ENC_10240(Uncharacterized conserved protein (DUF2132).) BN373_22351(conserved hypothetical protein) Cluster5588 0 0 0 0 2 0 0 BN373_22171(GCN5-related N-acetyltransferase),BN373_28631(acetyltransferase, GNAT family) Cluster5589 0 1 0 0 1 0 0 ENC_10640(Acetyltransferase (GNAT) family.) BN373_22151(putative acyltransferase) Cluster5590 0 0 0 1 1 0 0 b1932(predicted acyltransferase) BN373_22091(acetyltransferase, GNAT family) Cluster5591 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3323(Toxin-antitoxin biofilm protein TabA,uncharacterized protein, YhcH/YjgK/YiaL family,Domain of unknown function (DUF386)) BN373_22001(conserved hypothetical protein) Cluster5592 0 1 0 0 1 0 0 ENC_10910(Rhodanese-related sulfurtransferase) BN373_21821(conserved hypothetical protein) Cluster5593 0 1 0 0 1 0 0 ENC_03090(Predicted ATPase) BN373_21751(RecF/RecN/SMC N-terminal domain protein) Cluster5594 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.80(Beta-lactamase TEM precursor,beta-lactamase TEM,Beta-lactamase) BN373_21711(beta-lactamase) Cluster5595 0 1 0 0 1 0 0 ENC_12350(Zn-dependent carboxypeptidase) BN373_21271(carboxypeptidase family protein) Cluster5596 0 1 0 0 1 0 0 ENC_42000(Predicted sugar phosphate isomerase) BN373_21091(conserved hypothetical protein) Cluster5597 0 1 0 0 1 0 0 ENC_41970(Membrane-associated lipoprotein involved in thiamine biosynthesis) BN373_21051(ApbE family protein) Cluster5598 0 1 0 0 1 0 0 ENC_16510(Small-conductance mechanosensitive channel) BN373_21011(transporter, small conductance mechanosensitive ion channel (MscS) family) Cluster5599 1 0 0 0 1 0 0 ROD_16631(putative 4-carboxymuconolactone decarboxylase) BN373_21001(4-carboxymuconolactone decarboxylase) Cluster5600 1 0 0 0 1 0 0 ROD_16641(pyrimidine utilization protein D) BN373_20991(3-oxoadipate enol-lactonase) Cluster5601 1 0 0 0 1 0 0 ROD_16651(3-carboxy-cis,cis-muconate cycloisomerase) BN373_20981(3-carboxy-cis,cis-muconate cycloisomerase) Cluster5602 1 0 0 0 1 0 0 ROD_16671(acetate CoA-transferase beta subunit) BN373_20961(3-oxoadipate CoA-transferase, subunit B) Cluster5603 1 0 0 0 1 0 0 ROD_16681(acetate CoA-transferase alpha subunit) BN373_20951(3-oxoadipate CoA-transferase, subunit A) Cluster5604 1 0 0 0 1 0 0 ROD_16691(putative Pca regulon regulatory protein) BN373_20941(Pca regulon regulatory protein) Cluster5605 0 0 0 1 1 0 0 b1336(p-aminobenzoyl-glutamate transporter; membrane protein) BN373_20891(aminobenzoyl-glutamate transport protein) Cluster5606 1 0 0 0 1 0 0 ROD_16251(Major Facilitator Superfamily transporter) BN373_20551(transporter, major facilitator family) Cluster5607 0 1 0 0 1 0 0 ENC_11370(Major Facilitator Superfamily.) BN373_20431(transporter, major facilitator family) Cluster5608 0 1 0 0 1 0 0 ENC_11410(Predicted O-methyltransferase) BN373_20401(putative o-methyltransferase) Cluster5609 0 0 0 1 1 0 0 b1394(1,2-epoxyphenylacetyl-CoA isomerase, oxepin-CoA-forming) BN373_20301(enoyl-CoA hydratase PaaG) Cluster5610 0 0 0 1 1 0 0 b1392(ring 1,2-phenylacetyl-CoA epoxidase, NAD(P)H oxidoreductase component) BN373_20281(phenylacetate-CoA oxygenase, NAD(P)H oxidoreductase component PaaE) Cluster5611 0 0 0 1 1 0 0 b1387(fused oxepin-CoA hydrolase/3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase) BN373_20231(phenylacetic acid degradation protein MaoC) Cluster5612 0 0 0 1 1 0 0 b1386(tyramine oxidase, copper-requiring) BN373_20221(copper amine oxidase) Cluster5613 0 0 0 0 2 0 0 BN373_20161(conserved hypothetical protein),BN373_p01431(conserved hypothetical protein) Cluster5614 0 0 0 0 2 0 0 BN373_20141(amino acid ABC transporter, permease/ATP-binding protein, His/Glu/Gln/Arg/opine family),BN373_36151(amino acid ABC transporter, permease protein/ATP-binding protein) Cluster5615 0 0 0 0 2 0 0 BN373_20121(ABC transporter, periplasmic substrate-binding protein),BN373_36141(amino acid ABC transporter, periplasmic amino acid-binding protein) Cluster5616 0 0 0 0 2 0 0 BN373_20111(class II aldolase/adducin N-terminal domain protein),BN373_36161(class II aldolase/adducin domain protein) Cluster5617 0 0 0 0 2 0 0 BN373_20101(putative 2-dehydropantoate 2-reductase),BN373_30311(2-dehydropantoate 2-reductase) Cluster5618 0 1 0 0 1 0 0 ENC_11320(Transcriptional regulators of sugar metabolism) BN373_19931(transcriptional regulator, DeoR family) Cluster5619 0 0 0 0 2 0 0 BN373_19801(transcriptional regulator, TetR family),BN373_27281(putative TetR-family trancriptional regulatory protein) Cluster5620 0 1 0 0 1 0 0 ENC_09120(hypothetical protein) BN373_19691(conserved hypothetical protein) Cluster5621 0 0 0 0 2 0 0 BN373_19621(PaaR repeat-containing protein),BN373_28471(conserved hypothetical protein) Cluster5622 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.944(Uncharacterized conserved protein,Uncharacterized conserved protein (DUF2235)) BN373_19611(conserved hypothetical protein) Cluster5623 0 1 0 0 1 0 0 ENC_09310(hypothetical protein) BN373_19436(cold-shock protein) Cluster5624 0 1 0 0 1 0 0 ENC_12230(Arabinose efflux permease) BN373_19411(putative transcriptional regulatory protein OpdE) Cluster5625 0 1 0 0 1 0 0 ENC_12210(transcriptional regulator, LysR family) BN373_19391(transcriptional regulator, LysR family) Cluster5626 0 1 0 0 1 0 0 ENC_23340(6-phospho-beta-glucosidase) BN373_19311(putative alpha-galactosidases/6-phospho-beta-glucosidase) Cluster5627 1 0 0 0 1 0 0 ROD_13281(2-deoxy-d-gluconate 3-dehydrogenase) BN373_18631(putative 2-deoxy-D-gluconate 3-dehydrogenase) Cluster5628 0 1 0 0 1 0 0 ENC_05660(putative NAD(P)H quinone oxidoreductase, PIG3 family) BN373_18321(putative NAD(P)H quinone oxidoreductase, PIG3 family) Cluster5629 0 0 0 0 2 0 0 BN373_18101(transcriptional regulator, LysR family),BN373_27341(transcriptional regulator, LysR family) Cluster5630 0 1 0 0 1 0 0 ENC_16470(Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)) BN373_18081(NAD dependent epimerase/dehydratase family protein) Cluster5631 0 1 0 0 1 0 0 ENC_10020(transcriptional regulator, LysR family) BN373_18071(transcriptional regulator, LysR family) Cluster5632 1 0 0 0 1 0 0 ROD_12612(conserved hypothetical protein) BN373_17971(conserved hypothetical protein) Cluster5633 1 0 0 0 1 0 0 ROD_35151(hypothetical protein) BN373_17871(putative metal-dependent phosphohydrolase) Cluster5634 0 1 0 0 1 0 0 ENC_10260(transcriptional regulator, LysR family) BN373_17851(transcriptional regulator, LysR family) Cluster5635 0 1 0 0 1 0 0 ENC_10250(3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases) BN373_17841(3-octaprenyl-4-hydroxybenzoate carboxy-lyase family protein) Cluster5636 1 0 0 0 1 0 0 ROD_16881(conserved hypothetical protein) BN373_17721(conserved hypothetical protein) Cluster5637 1 0 0 0 1 0 0 ROD_33861(hypothetical protein) BN373_17691(ACT domain protein) Cluster5638 0 1 0 0 1 0 0 ENC_44450(Predicted transcriptional regulators) BN373_17681(transcriptional regulator, ArsR family) Cluster5639 0 0 0 0 2 0 0 BN373_17671(putative cyclic diguanylate phosphodiesterase),BN373_17821(cyclic diguanylate phosphodiesterase) Cluster5640 0 1 0 0 1 0 0 ENC_16990(hypothetical protein) BN373_17651(conserved hypothetical protein) Cluster5641 0 1 0 0 1 0 0 ENC_42290(transcriptional regulator, AraC family) BN373_17541(transcriptional regulator, AraC family) Cluster5642 1 0 0 0 1 0 0 ROD_50591(transaldolase A) BN373_17401(putative transaldolase) Cluster5643 1 0 0 0 1 0 0 ROD_50571(putative PTS system, IIa component) BN373_17381(PTS system, glucitol/sorbitol-specific IIA component) Cluster5644 1 0 0 0 1 0 0 ROD_50551(putative PTS system, IIbc component) BN373_17361(sorbitol phosphotransferase enzyme II) Cluster5645 1 0 0 0 1 0 0 ROD_50541(PdxA-like protein) BN373_17351(putative 4-hydroxythreonine-4-phosphate dehydrogenase) Cluster5646 1 0 0 0 1 0 0 ROD_50521(putative triosephosphate isomerase) BN373_17341(triosephosphate isomerase) Cluster5647 1 0 0 0 1 0 0 ROD_03761(putative transcriptional regulator) BN373_17331(putative sugar-binding domain protein) Cluster5648 1 0 0 0 1 0 0 ROD_11451(putative LysR-family transcriptional regulator) BN373_16961(transcriptional regulator, LysR family) Cluster5649 1 0 0 0 1 0 0 ROD_11441(putative Major Facilitator Superfamily transporter) BN373_16951(transporter, major facilitator family) Cluster5650 0 1 0 0 1 0 0 ENC_16170(Protein of unknown function (DUF3574).) BN373_16581(putative lipoprotein) Cluster5651 0 1 0 0 1 0 0 ENC_36050(Short-chain dehydrogenases of various substrate specificities) BN373_16381(oxidoreductase, short chain dehydrogenase/reductase family) Cluster5652 0 0 0 1 1 0 0 b1801(predicted transporter) BN373_16271(transporter, betaine/carnitine/choline transporter (BCCT) family) Cluster5653 0 0 0 1 1 0 0 b1802(predicted 2Fe-2S cluster-containing protein) BN373_16261(Rieske 2Fe-2S domain protein) Cluster5654 0 0 0 1 1 0 0 b1803(predicted oxidoreductase) BN373_16241(oxidoreductase, FAD/NAD-binding/iron-sulfur cluster binding protein) Cluster5655 0 1 0 0 1 0 0 ENC_18460(His Kinase A (phosphoacceptor) domain./Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.) BN373_15071(sensor histidine kinase) Cluster5656 0 1 0 0 1 0 0 ENC_18470(Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain) BN373_15061(DNA-binding response regulator) Cluster5657 0 0 0 0 1 1 0 BN373_14891(phage tail tape measure protein, family) t4297(hypothetical protein) Cluster5658 0 0 0 0 1 0 1 BN373_14741(conserved hypothetical protein) SL1344_2683(putative conserved bacteriophage protein (thought to be involved in host lysis)) Cluster5659 0 0 0 0 1 1 0 BN373_14541(conserved hypothetical protein) t3403(hypothetical protein) Cluster5660 0 0 0 0 1 0 1 BN373_14511(acetyltransferase, gnat family) SL1344_2698(predicted bacteriophage protein) Cluster5661 0 0 0 0 1 0 1 BN373_14501(conserved hypothetical protein) SL1344_2697(predicted bacteriophage protein) Cluster5662 0 0 0 0 2 0 0 BN373_14471(conserved hypothetical protein),BN373_14481(conserved hypothetical protein) Cluster5663 1 0 0 0 1 0 0 ROD_29551(conserved hypothetical protein) BN373_14151(conserved hypothetical protein) Cluster5664 0 1 0 0 1 0 0 ENC_19000(Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosid ase) BN373_14121(glycosyl hydrolase, family 1) Cluster5665 0 1 0 0 1 0 0 ENC_21050(Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family) BN373_13991(conserved hypothetical protein) Cluster5666 1 0 0 0 1 0 0 ROD_08011(conserved hypothetical protein) BN373_13921(transketolase domain protein) Cluster5667 1 0 0 0 1 0 0 ROD_08001(conserved hypothetical protein) BN373_13911(transketolase family protein) Cluster5668 1 0 0 0 1 0 0 ROD_07991(putative exported protein) BN373_13901(oxidoreductase, short chain dehydrogenase/reductase family protein) Cluster5669 1 0 0 0 1 0 0 ROD_07981(Major Facilitator Superfamily transporter) BN373_13891(transporter, major facilitator family) Cluster5670 0 1 0 0 1 0 0 ENC_19580(amino acid/amide ABC transporter ATP-binding protein 2, HAAT family (TC 3.A.1.4.-)) BN373_13661(putative amino acid transporter) Cluster5671 0 1 0 0 1 0 0 ENC_41670(hypothetical protein) BN373_13501(conserved hypothetical protein) Cluster5672 0 1 0 0 1 0 0 ENC_41660(RND family efflux transporter, MFP subunit) BN373_13491(efflux transporter, RND family, MFP subunit) Cluster5673 0 1 0 0 1 0 0 ENC_41630(Uncharacterized protein conserved in bacteria) BN373_13471(putative membrane protein) Cluster5674 0 0 0 0 2 0 0 BN373_13461(conserved hypothetical protein),BN373_20641(conserved hypothetical protein) Cluster5675 1 0 0 0 1 0 0 pseudoROD_07161(pyrrolidone-carboxylate peptidase (fragment)) BN373_12981(pyrrolidone-carboxylate peptidase) Cluster5676 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4477(hypothetical protein) BN373_12831(putative membrane protein) Cluster5677 1 0 0 0 1 0 0 ROD_49921(putative haemolysin activator HlyB) BN373_12571(ShlB-type POTRA domain/haemolysin secretion/activation protein ShlB/FhaC/HecB) Cluster5678 1 0 0 0 1 0 0 ROD_49941(putative haemolysin/haemagglutinin) BN373_12561(putative filamentous hemagglutinin) Cluster5679 0 1 0 0 1 0 0 ENC_21180(acireductone synthase) BN373_12231(2,3-diketo-5-methylthio-1-phosphopentane phosphatase) Cluster5680 0 1 0 0 1 0 0 ENC_21190(acireductone dioxygenase apoprotein) BN373_12221(aci-reductone dioxygenase) Cluster5681 0 1 0 0 1 0 0 ENC_21170(methylthioribulose-1-phosphate dehydratase) BN373_12131(methylthioribulose-1-phosphate dehydratase) Cluster5682 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4112(Methylthioribose-1-phosphate isomerase,methylthioribose-1-phosphate isomerase,Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family,S-methyl-5-thioribose-1-phosphate isomerase,Initiation factor 2 subunit family) BN373_12051(S-methyl-5-thioribose-1-phosphate isomerase) Cluster5683 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4113(Methylthioribose kinase,methylthioribose kinase,Predicted kinase,5-methylthioribose kinase,Phosphotransferase enzyme family) BN373_12041(5-methylthioribose kinase) Cluster5684 0 1 0 0 1 0 0 ENC_21250(Uncharacterized conserved protein) BN373_12031(conserved hypothetical protein) Cluster5685 0 1 0 0 1 0 0 ENC_21260(monosaccharide ABC transporter substrate-binding protein, CUT2 family (TC 3.A.1.2.-)) BN373_12021(putative sugar ABC transporter, periplasmic sugar-binding protein) Cluster5686 0 1 0 0 1 0 0 ENC_21280(monosaccharide ABC transporter ATP-binding protein, CUT2 family (TC 3.A.1.2.-)) BN373_12001(putative sugar ABC transporter, ATP-binding protein) Cluster5687 0 1 0 0 1 0 0 ENC_21320(Cytotoxic translational repressor of toxin-antitoxin stability system) BN373_11971(plasmid stabilization system protein, RelE/ParE family) Cluster5688 0 1 0 0 1 0 0 ENC_21330(Helix-turn-helix.) BN373_11961(DNA binding protein) Cluster5689 1 0 0 0 1 0 0 ROD_05741(conserved hypothetical protein) BN373_11591(acetyltransferase, GNAT family) Cluster5690 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4389(Dipeptide-binding protein,glutathione ABC transporter substrate-binding protein GsiB,ABC-type oligopeptide transport system, periplasmic component,nickel ABC transporter, nickel/metallophore periplasmic binding protein,Bacterial extracellular solute-binding proteins, family 5 Middle) BN373_11581(ABC transporter, periplasmic substrate-binding protein) Cluster5691 0 0 0 0 2 0 0 BN373_11471(amino acid ABC transporter, permease protein),BN373_23401(amino acid ABC transporter, permease protein) Cluster5692 0 0 0 0 2 0 0 BN373_11431(transcriptional regulator, GntR family/aminotransferase, classes I and II),BN373_p01501(conserved hypothetical protein) Cluster5693 0 0 0 0 2 0 0 BN373_11411(amidase, hydantoinase/carbamoylase family),BN373_15771(allantoate amidohydrolase) Cluster5694 0 1 0 0 1 0 0 ENC_21830(RND family efflux transporter, MFP subunit) BN373_11321(efflux transporter, RND family, MFP subunit) Cluster5695 0 1 0 0 1 0 0 ENC_21890(Predicted Zn-dependent hydrolases of the beta-lactamase fold) BN373_11271(multidrug resistance protein RomA) Cluster5696 0 0 0 0 1 0 1 BN373_11221(putative PTS system transport protein) SL1344_0564(putative mannose specific permease) Cluster5697 0 0 0 0 1 0 1 BN373_11211(putative inner membrane protein) SL1344_0563(putative mannose specific permease) Cluster5698 0 0 0 0 1 0 1 BN373_11201(putative PTS system transport protein) SL1344_0562(putative mannose specific permease) Cluster5699 0 0 0 0 1 0 1 BN373_11191(putative inner membrane protein) SL1344_0561(Putative GTP Binding protein) Cluster5700 0 0 0 0 1 0 1 BN373_11181(putative phosphosugar isomerase) SL1344_0560(similar to a putative phospohtase isomerase) Cluster5701 0 0 0 0 1 0 1 BN373_11171(putative inner membrane protein) SL1344_0559(sigma 54-associated DNA-binding protein) Cluster5702 0 1 0 0 1 0 0 ENC_21960(hypothetical protein) BN373_11151(conserved hypothetical protein) Cluster5703 0 1 0 0 1 0 0 ENC_21970(Arabinose efflux permease) BN373_11141(transporter, major facilitator family) Cluster5704 0 1 0 0 1 0 0 ENC_21990(transcriptional regulator, LacI family) BN373_11121(sugar binding transcriptional regulator, LacI family) Cluster5705 0 1 0 0 1 0 0 ENC_08080(hypothetical protein) BN373_11111(putative lipoprotein) Cluster5706 0 1 0 0 1 0 0 ENC_22000(Predicted dehydrogenases and related proteins) BN373_11101(oxidoreductase family protein) Cluster5707 0 1 0 0 1 0 0 ENC_22010(Sugar phosphate isomerases/epimerases) BN373_11091(AP endonuclease, family 2) Cluster5708 0 1 0 0 1 0 0 ENC_11950(hypothetical protein) BN373_11051(putative lipoprotein) Cluster5709 0 0 0 0 1 0 1 BN373_10941(putative iron-sulfur modifier protein) SL1344_3097(arylsulfatase regulator) Cluster5710 0 0 0 0 1 0 1 BN373_10931(arylsulfatase) SL1344_3096(arylsulfatase) Cluster5711 1 0 0 0 1 0 0 ROD_31501(putative exported protein) BN373_10851(conserved hypothetical protein) Cluster5712 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1002(Sucrose porin precursor,maltoporin,Maltoporin (phage lambda and maltose receptor),LamB porin) BN373_10781(sucrose porin ScrY) Cluster5713 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.1001(PTS system sac EIIBC component,PTS system trehalose(maltose)-specific transporter subunits IIBC,PTS system, sucrose-specific IIBC component,Phosphotransferase system, EIIC) BN373_10771(PTS system sucrose-specific EIIBC component) Cluster5714 0 0 0 0 2 0 0 BN373_10721(sugar ABC transporter, periplasmic substrate-binding protein),BN373_28391(putative periplasmic sugar-binding protein) Cluster5715 0 0 0 0 2 0 0 BN373_10711(putative transcriptional regulator),BN373_23701(transcriptional regulator, LacI family) Cluster5716 0 0 0 0 2 0 0 BN373_10491(conserved hypothetical protein),BN373_33421(conserved hypothetical protein) Cluster5717 0 0 0 0 2 0 0 BN373_10481(conserved hypothetical protein),BN373_33431(conserved hypothetical protein) Cluster5718 0 1 0 0 1 0 0 ENC_27840(NlpC/P60 family.) BN373_10461(conserved hypothetical protein) Cluster5719 0 1 0 0 1 0 0 ENC_27830(hypothetical protein) BN373_10451(conserved hypothetical protein) Cluster5720 0 1 0 0 1 0 0 ENC_27820(hypothetical protein) BN373_10441(conserved hypothetical protein) Cluster5721 0 1 0 0 1 0 0 ENC_27810(hypothetical protein) BN373_10431(conserved hypothetical protein) Cluster5722 0 1 0 0 1 0 0 ENC_27770(hypothetical protein) BN373_10331(conserved hypothetical protein) Cluster5723 0 1 0 0 1 0 0 ENC_27760(hypothetical protein) BN373_10321(conserved hypothetical protein) Cluster5724 0 1 0 0 1 0 0 ENC_27710(Uncharacterized protein conserved in bacteria) BN373_10191(conserved hypothetical protein) Cluster5725 0 1 0 0 1 0 0 ENC_27700(Phage terminase, small subunit) BN373_10181(conserved hypothetical protein) Cluster5726 1 0 0 0 1 0 0 ROD_10412(putative prophage exported protein) BN373_10161(conserved hypothetical protein) Cluster5727 0 0 0 0 1 0 1 BN373_09971(replication protein) SL1344_1964(putative replication protein) Cluster5728 0 0 0 0 2 0 0 BN373_09921(conserved hypothetical protein),BN373_10981(conserved hypothetical protein) Cluster5729 0 1 0 0 1 0 0 ENC_27650(AP2 domain.) BN373_09861(Pathogenesis-related transcriptional factor and ERF protein) Cluster5730 0 1 0 0 1 0 0 ENC_27470(hypothetical protein) BN373_09821(conserved hypothetical protein) Cluster5731 0 0 0 0 2 0 0 BN373_09751(conserved hypothetical protein),BN373_10501(conserved hypothetical protein) Cluster5732 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3455(hypothetical protein) BN373_09681(putative membrane protein) Cluster5733 0 1 0 0 1 0 0 ENC_22830(Predicted membrane protein) BN373_09101(putative membrane protein) Cluster5734 0 1 0 0 1 0 0 ENC_22840(transcriptional regulator, GntR family) BN373_09091(transcriptional regulator, GntR family/aminotransferase family protein) Cluster5735 0 1 0 0 1 0 0 ENC_22850(hypothetical protein) BN373_09086(hypothetical protein) Cluster5736 0 1 0 0 1 0 0 ENC_22860(hypothetical protein) BN373_09081(conserved hypothetical protein) Cluster5737 1 0 0 0 1 0 0 ROD_04831(putative IclR-family transcriptional regulator) BN373_08771(transcriptional regulator, IclR family) Cluster5738 1 0 0 0 1 0 0 ROD_04821(quinate/shikimate dehydrogenase) BN373_08761(putative shikimate 5-dehydrogenase) Cluster5739 1 0 0 0 1 0 0 ROD_04811(putative exported protein) BN373_08751(FAD-dependent oxidoreductase) Cluster5740 1 0 0 0 1 0 0 ROD_04801(conserved hypothetical protein) BN373_08741(conserved hypothetical protein) Cluster5741 1 0 0 0 1 0 0 ROD_04791(putative flavoprotein subunit of a reductase) BN373_08731(FAD-dependent oxidoreductase) Cluster5742 1 0 0 0 1 0 0 ROD_04781(conserved hypothetical protein) BN373_08721(AP endonuclease, family 2) Cluster5743 1 0 0 0 1 0 0 ROD_04771(Major Facilitator Superfamily transporter) BN373_08711(4-hydroxybenzoate transporter) Cluster5744 0 0 0 0 2 0 0 BN373_08701(oxidoreductase, NAD binding),BN373_23721(oxidoreductase, NAD-binding) Cluster5745 0 1 0 0 1 0 0 ENC_44260(Amidases related to nicotinamidase) BN373_08341(isochorismatase hydrolase family protein) Cluster5746 1 0 0 0 1 0 0 ROD_16831(conserved hypothetical protein) BN373_08061(isochorismatase family protein) Cluster5747 0 1 0 0 1 0 0 ENC_23920(Putative hemolysin) BN373_08031(acyltransferase domain protein) Cluster5748 1 0 0 0 1 0 0 ROD_03751(putative membrane protein) BN373_07461(conserved hypothetical protein) Cluster5749 0 1 0 0 1 0 0 ENC_24600(Uncharacterized protein conserved in bacteria) BN373_07286(Protein of unknown function (DUF539)) Cluster5750 0 1 0 0 1 0 0 ENC_24610(NADH:ubiquinone oxidoreductase, Na(+)-translocating, F subunit) BN373_07281(NADH:ubiquinone oxidoreductase, na(+)-translocating, F subunit) Cluster5751 0 1 0 0 1 0 0 ENC_24620(NADH:ubiquinone oxidoreductase, Na(+)-translocating, E subunit) BN373_07271(NADH:ubiquinone oxidoreductase, Na(+)-translocating, e subunit) Cluster5752 0 1 0 0 1 0 0 ENC_24630(NADH:ubiquinone oxidoreductase, Na(+)-translocating, D subunit) BN373_07261(NADH:ubiquinone oxidoreductase, Na(+)-translocating, D subunit) Cluster5753 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.176(Na(+)-translocating NADH-quinone reductase subunit C,Na(+)-translocating NADH-quinone reductase subunit C,Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC,NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit,FMN-binding domain) BN373_07251(NADH:ubiquinone oxidoreductase, na(+)-translocating, C subunit) Cluster5754 0 1 0 0 1 0 0 ENC_24650(NADH:ubiquinone oxidoreductase, Na(+)-translocating, B subunit) BN373_07241(NADH:ubiquinone oxidoreductase, na(+)-translocating, B subunit) Cluster5755 0 1 0 0 1 0 0 ENC_24660(NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit) BN373_07231(NADH:ubiquinone oxidoreductase, na(+)-translocating, A subunit) Cluster5756 0 1 0 0 1 0 0 ENC_18290(prepilin-type N-terminal cleavage/methylation domain) BN373_06461(pullulanase secretion protein PulH) Cluster5757 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.750(PilD-dependent protein pddD,Type II secretory pathway, component PulJ,type II secretion system protein J,Pseudopilin GspJ) BN373_06441(pullulanase secretion protein PulJ) Cluster5758 0 0 0 0 2 0 0 BN373_05591(transporter, anion:cation symporter (ACS) family),BN373_27141(transporter, major facilitator family) Cluster5759 0 1 0 0 1 0 0 ENC_32220(Na+/citrate symporter) BN373_05421(citrate:acetate antiporter) Cluster5760 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.3964(Predicted membrane protein,Protein of unknown function (DUF805)) BN373_05071(putative membrane protein) Cluster5761 0 1 0 0 1 0 0 ENC_44880(PTS system, lactose/cellobiose family IIC component) BN373_04481(PTS system, lactose/cellobiose family IIC component) Cluster5762 1 0 0 0 1 0 0 ROD_48661(AraC-family transcriptional regulator) BN373_04441(transcriptional regulator PobR) Cluster5763 1 0 0 0 1 0 0 ROD_48651(putative monooxygenase) BN373_04431(4-hydroxybenzoate 3-monooxygenase) Cluster5764 1 0 0 0 1 0 0 ROD_48451(putative transcriptional regulator) BN373_04251(putative transcriptional regulator) Cluster5765 1 0 0 0 1 0 0 ROD_48431(putative 2-oxo-3-deoxygalactonate kinase) BN373_04231(2-oxo-3-deoxygalactonate kinase) Cluster5766 1 0 0 0 1 0 0 ROD_48421(putative transport protein) BN373_04221(sodium/panthothenate symporter) Cluster5767 1 0 0 0 1 0 0 ROD_48411(conserved hypothetical protein) BN373_04211(conserved hypothetical protein) Cluster5768 1 0 0 0 1 0 0 ROD_48401(putative N-acyl-D-amino-acid deacylase) BN373_04201(conserved hypothetical protein) Cluster5769 1 0 0 0 1 0 0 ROD_48391(conserved hypothetical protein) BN373_04191(conserved hypothetical protein) Cluster5770 0 1 0 0 1 0 0 ENC_44560(YfaZ precursor.) BN373_03981(YfaZ family protein) Cluster5771 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4062(Protein of unknown function (DUF3343)) BN373_03881(conserved hypothetical protein) Cluster5772 0 1 0 0 1 0 0 ENC_44480(Protein of unknown function (DUF2955).) BN373_03871(putative membrane protein) Cluster5773 0 1 0 0 1 0 0 ENC_44470(Multidrug resistance efflux pump) BN373_03861(auxiliary transport protein, membrane fusion protein (MFP) family) Cluster5774 0 1 0 0 1 0 0 ENC_44460(transcriptional regulator, MarR family) BN373_03851(transcriptional regulator, MarR family) Cluster5775 0 1 0 0 1 0 0 ENC_44180(Lactoylglutathione lyase and related lyases) BN373_03821(glutathione transferase, FosA) Cluster5776 1 0 0 0 1 0 0 ROD_24841(putative ABC transporter membrane protein) BN373_03791(ribose high-affinity abc transport system permease component) Cluster5777 1 0 0 0 1 0 0 ROD_24831(putative ABC transporter membrane protein) BN373_03781(ribose high-affinity ABC transport system permease component) Cluster5778 1 0 0 0 1 0 0 ROD_24821(putative ABC transporter ATP-binding protein) BN373_03771(ribose high-affinity ABC transport system inner-membrane translocator) Cluster5779 1 0 0 0 1 0 0 ROD_24811(ABC transporter, substrate-binding protein) BN373_03761(putative LacI-type transcriptional regulator) Cluster5780 0 1 0 0 1 0 0 ENC_44350(Uncharacterized conserved protein) BN373_03691(cupin family protein) Cluster5781 0 1 0 0 1 0 0 ENC_11520(hypothetical protein) BN373_03501(putative lipoprotein) Cluster5782 0 0 0 0 2 0 0 BN373_03341(4-phytase),BN373_12061(histidine acid phosphatase family protein) Cluster5783 1 0 0 0 1 0 0 ROD_34081(conserved hypothetical protein) BN373_03231(conserved hypothetical protein) Cluster5784 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4116(5-methylcytosine-specific restriction enzyme subunit McrC,McrBC 5-methylcytosine restriction system component,McrBC 5-methylcytosine restriction system component) BN373_03181(5-methylcytosine restriction system component) Cluster5785 0 1 0 0 1 0 0 ENC_35590(Predicted ATPase) BN373_03101(nucleoside triphosphate hydrolase) Cluster5786 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.157(sn-glycerol-3-phosphate transport system permease protein ugpA,glycerol-3-phosphate transporter permease,ABC-type polysaccharide transport system, permease component,putative 2-aminoethylphosphonate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component) BN373_03021(ABC transporter, permease protein) Cluster5787 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.158(Inner membrane ABC transporter permease protein ycjP,glycerol-3-phosphate transporter membrane protein,ABC-type maltose transport systems, permease component,NifC-like ABC-type porter,Binding-protein-dependent transport system inner membrane component) BN373_03011(ABC transporter, permease protein) Cluster5788 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.159(3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA,cyclic 3',5'-adenosine monophosphate phosphodiesterase,Predicted phosphoesterase or phosphohydrolase,metallophosphoesterase, PPA1498 family,Calcineurin-like phosphoesterase) BN373_03001(putative phosphodiesterase) Cluster5789 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.160(sn-glycerol-3-phosphate import ATP-binding protein UgpC,glycerol-3-phosphate transporter ATP-binding subunit,ABC-type spermidine/putrescine transport systems, ATPase components,putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein,ABC transporter) BN373_02991(sugar ABC transporter, ATP-binding protein) Cluster5790 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_6_5133360-5301568.161(glycerol-3-phosphate transporter periplasmic binding protein,Maltose-binding periplasmic proteins/domains,carbohydrate ABC transporter substrate-binding protein, CPR_0540 family,Bacterial extracellular solute-binding protein) BN373_02981(ABC transporter, periplasmic substrate-binding protein) Cluster5791 0 0 0 0 1 0 1 BN373_02971(inosose dehydratase) SL1344_4356(inosose dehydratase) Cluster5792 0 0 0 0 1 0 1 BN373_02961(protein IolH) SL1344_4366(putative endonuclease) Cluster5793 0 0 0 0 1 0 1 BN373_02951(inositol 2-dehydrogenase) SL1344_4357(inositol 2-dehydrogenase) Cluster5794 0 0 0 0 1 0 1 BN373_02941(thiamine pyrophosphate enzyme) SL1344_4362(putative malonic semialdehyde oxidative decarboxylase) Cluster5795 0 0 0 0 1 0 1 BN373_02931(kinase, pfkB family) SL1344_4361(putative carbohydrate kinase) Cluster5796 0 0 0 0 1 0 1 BN373_02921(transcriptional regulator, RpiR family) SL1344_4350(putative transcriptional regulator) Cluster5797 0 0 0 0 1 0 1 BN373_02881(myo-inositol catabolism protein) SL1344_4353(putative isomerase) Cluster5798 0 0 0 0 1 0 1 BN373_02871(methylmalonate-semialdehyde dehydrogenase (acylating)) SL1344_4354(methylmalonate-semialdehyde dehydrogenase) Cluster5799 0 0 0 0 1 0 1 BN373_02861(AP endonuclease, family 2) SL1344_4365(xylose isomerase) Cluster5800 0 1 0 0 1 0 0 ENC_37880(phosphotransferase system, cellobiose specific, IIC component) BN373_02611(putative phosphotransferase protein) Cluster5801 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.445(hypothetical protein) BN373_02401(conserved hypothetical protein) Cluster5802 0 0 0 0 2 0 0 BN373_02291(conserved hypothetical protein),BN373_02311(conserved hypothetical protein) Cluster5803 0 0 0 0 2 0 0 BN373_02221(glycosyl hydrolase, family 42),BN373_09191(beta-galactosidase) Cluster5804 1 0 0 0 1 0 0 ROD_25471(putative AraC-family transcriptional regulator) BN373_02141(transcriptional regulator, AraC family) Cluster5805 1 0 0 0 1 0 0 ROD_11881(Major Facilitator Superfamily transporter) BN373_02031(transporter, major facilitator family) Cluster5806 0 1 0 0 1 0 0 ENC_42470(Predicted small secreted protein) BN373_01591(entericidin A) Cluster5807 1 0 0 0 1 0 0 ROD_03711(microcin secretion protein) BN373_01491(microcin H47 secretion protein) Cluster5808 1 0 0 0 1 0 0 ROD_31971(putative exported protein) BN373_01351(conserved domain protein) Cluster5809 0 1 0 0 1 0 0 ENC_32300(Bacterial regulatory proteins, luxR family.) BN373_01301(transcriptional regulator, LuxR family) Cluster5810 0 1 0 0 1 0 0 ENC_32340(hypothetical protein) BN373_01251(putative biofilm PGA synthesis protein PgaD) Cluster5811 0 1 0 0 1 0 0 ENC_05170(His Kinase A (phosphoacceptor) domain./Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase./Response regulator receiver domain./HAMP domain.) BN373_01011(sensor histidine kinase/response regulator) Cluster5812 0 1 0 0 1 0 0 ENC_05160(monosaccharide ABC transporter ATP-binding protein, CUT2 family (TC 3.A.1.2.-)) BN373_01001(putative ribose ABC transporter, ATP-binding protein) Cluster5813 0 1 0 0 1 0 0 ENC_05110(Sugar kinases, ribokinase family) BN373_00971(kinase, pfkB family) Cluster5814 0 1 0 0 1 0 0 ENC_05100(Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain) BN373_00941(DNA-binding response regulator) Cluster5815 0 0 0 0 1 0 1 BN373_00841(fimbrial protein) SL1344_4518(putative fimbrial subunit) Cluster5816 0 0 0 0 2 0 0 BN373_00681(ABC transporter, permease protein),BN373_03401(ABC transporter, permease subunit) Cluster5817 0 0 0 0 2 0 0 BN373_00661(ABC transporter, periplasmic substrate-binding protein),BN373_03391(ABC transporter periplasmic binding protein) Cluster5818 0 0 0 0 2 0 0 BN373_00631(sugar binding transcriptional regulator, LacI family),BN373_12091(sugar-binding domain protein, LacI family) Cluster5819 0 0 0 0 2 0 0 BN373_00621(putative inositol-1-monophosphatase),BN373_12081(inositol monophosphatase family protein) Cluster5820 0 1 0 0 1 0 0 ENC_16230(Acetyltransferase (GNAT) family.) BN373_00221(ribosomal-protein-alanine N-acetyltransferase) Cluster5821 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4468(Sor operon activator,transcriptional regulator LsrR,Transcriptional regulator, contains sigma factor-related N-terminal domain,RNA polymerase sigma factor, sigma-70 family,Putative sugar-binding domain) BN373_00151(sorbitol operon regulator) Cluster5822 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4469(3-oxoacyl-[acyl-carrier-protein] reductase FabG,sorbitol-6-phosphate 2-dehydrogenase,Uncharacterized conserved protein,3-oxoacyl-[acyl-carrier-protein] reductase,short chain dehydrogenase) BN373_00141(sorbitol-6-phosphate 2-dehydrogenase) Cluster5823 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4470(EIIAB-Man,PTS system mannose-specific transporter subunits IIAB,PTS system, mannose/fructose/sorbose family, IIA component,PTS system fructose IIA component) BN373_00131(sorbose-specific phosphotransferase enzyme IIA component) Cluster5824 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4471(Sorbose-specific phosphotransferase enzyme IIB component,PTS system mannose-specific transporter subunits IIAB,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB,PTS system, mannose/fructose/sorbose family, IIB component,PTS system sorbose subfamily IIB component) BN373_00121(sorbose-specific phosphotransferase enzyme IIB component) Cluster5825 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4472(PTS system mannose-specific EIIC component,PTS system mannose-specific transporter subunit IIC,Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC,PTS system, mannose/fructose/sorbose family, IIC component,PTS system sorbose-specific iic component) BN373_00111(sorbose permease IIC component) Cluster5826 0 0 1 0 1 0 0 Escherichia_coli_UPEC_ST131_v0.1_1_1-5052382.4473(PTS system mannose-specific EIID component,PTS system mannose-specific transporter subunit IID,PTS system, mannose/fructose/sorbose family, IID component,PTS system mannose/fructose/sorbose family IID component) BN373_00101(sorbose permease IID component)