Sample Barcode 1 Barcode 2 Variant type/consequence Symbol (Gene ID) cDNA effect Protein effect Codons Chromosome Position Ref Alt IGV links Confidence Allele fraction 1 Allele fraction 2 Depth 1 Depth 2 Filter 1 Filter 2 Quality 1 Quality 2 Amplicon PubMed Gene Exon Intron Existing variation SIFT PolyPhen Clinical significance GMAF Offset from primer end Sample type Indel length 5' context Alleles 3' context CMDL140066 FLD0001 FLD0025 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.506 0.451 1254 1314 pass pass 23265 20574 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140066 FLD0001 FLD0025 synonymous EGFR c.2364C>T c.2364C>T(p.%3D) ctC/ctT chr7 55249066 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249066", "IGV") low 0.083 1254 QD no call 797 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs201469865 27 FFPE CAGCT C/T ATCAC CMDL140066 FLD0001 FLD0025 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.550 0.497 1305 1340 pass pass 26197 22947 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140066 FLD0001 FLD0025 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.433 0.477 1471 1407 pass pass 21483 23488 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140066 FLD0001 FLD0025 intron TP53 c.96+23G>A chr17 7579677 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579677", "IGV") low 0.199 763 no call QD 468 EXP0116_TP53_E3 ENSG00000141510 3 of 10 58 FFPE AGGTC C/T CCAGC CMDL140066 FLD0001 FLD0025 intron TP53 c.96+13G>A chr17 7579687 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579687", "IGV") low 0.107 763 no call QD 397 EXP0116_TP53_E3 ENSG00000141510 3 of 10 48 FFPE CCCAA C/T CCTTG CMDL140066 FLD0001 FLD0025 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.025 87 no call QD 147 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL140066 FLD0001 FLD0025 intron PTEN c.802-12T>C chr10 89720639 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720639", "IGV") low 0.015 80 QD no call 153 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs587781129 benign 46 FFPE TTTTT T/C TTTTT CMDL140066 FLD0001 FLD0025 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.992 1160 no call pass 47916 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140066 FLD0001 FLD0025 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.079 1017 QD no call 96 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL140066 FLD0001 FLD0025 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.998 0.992 2039 1879 pass pass 74728 67719 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140066 FLD0001 FLD0025 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.995 0.987 1179 1070 pass pass 37714 35788 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140081 FLD0002 FLD0026 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.609 0.445 1767 1423 pass pass 39778 22019 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140081 FLD0002 FLD0026 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.512 0.473 1557 1420 pass pass 29068 23418 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140081 FLD0002 FLD0026 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.988 0.990 1764 1534 pass pass 74607 65340 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140081 FLD0002 FLD0026 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.119 1095 no call QD 156 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL140081 FLD0002 FLD0026 intron TP53 c.96+18G>A chr17 7579682 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579682", "IGV") medium 0.166 1048 pass no call 2854 EXP0116_TP53_E3 ENSG00000141510 3 of 10 53 FFPE CCCAG C/T CCAAC CMDL140081 FLD0002 FLD0026 nonsynonymous KRAS c.35G>T p.G12V gGt/gTt chr12 25398284 C A =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") high 0.354 0.344 3888 3516 pass pass 19690 17556 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) possibly_damaging(0.479) 26 FFPE CGCCA C/A CAGCT CMDL140081 FLD0002 FLD0026 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.003 1059 no call QD 297 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL140081 FLD0002 FLD0026 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.995 1060 no call QD 297 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140081 FLD0002 FLD0026 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") medium 0.132 0.152 1219 825 pass QD 2611 689 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL140081 FLD0002 FLD0026 intron TP53 c.74+53C>T chr17 7579786 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579786", "IGV") low 0.098 1222 QD no call 724 TP53_E00001596491_1 ENSG00000141510 2 of 10 9 FFPE TAGGG G/A GCTGG CMDL140081 FLD0002 FLD0026 intron TP53 c.74+49C>T chr17 7579790 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579790", "IGV") low 0.107 1245 QD no call 342 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs762400295 13 FFPE GGGCT G/A GGGTT CMDL140081 FLD0002 FLD0026 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.996 0.996 2453 1646 pass pass 89749 62176 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140081 FLD0002 FLD0026 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.994 0.993 1493 1360 pass pass 49812 46895 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140081 FLD0002 FLD0026 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.170 0.123 3157 2888 pass QD 6785 1336 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140083 FLD0003 FLD0027 intron EGFR c.2284-53C>T chr7 55248933 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248933", "IGV") low 0.100 1799 no call QD 969 EGFR_E00001601336_1 ENSG00000146648 19 of 27 13 FFPE TGCCC C/T TCCTT CMDL140083 FLD0003 FLD0027 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.986 0.998 1834 1839 pass pass 76879 71884 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140083 FLD0003 FLD0027 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") high 0.411 0.512 1015 1169 pass pass 8812 11676 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL140083 FLD0003 FLD0027 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.157 1015 QD no call 999 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL140083 FLD0003 FLD0027 nonsynonymous PIK3CA c.1637A>G p.Q546R cAg/cGg chr3 178936095 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178936095", "IGV") high 0.340 0.537 730 817 pass pass 7861 16189 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 rs397517201, COSM767, COSM25041, COSM12459, COSM446012, COSM1041496, COSM1757082 deleterious(0.02) probably_damaging(0.984) pathogenic 32 FFPE TGAGC A/G GGAGA CMDL140083 FLD0003 FLD0027 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.017 142 no call QD 81 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL140083 FLD0003 FLD0027 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.633 0.607 2037 2039 pass pass 32473 30254 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140083 FLD0003 FLD0027 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.823 0.837 1197 1141 pass pass 24658 24864 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140128 FLD0004 FLD0028 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.993 0.994 1615 1477 pass pass 68257 62634 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140128 FLD0004 FLD0028 intron TP53 c.97-33G>A chr17 7579623 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579623", "IGV") medium 0.210 342 no call pass 2107 EXP0116_TP53_E3 ENSG00000141510 3 of 10 47 FFPE AGGAC C/T AGGTC CMDL140128 FLD0004 FLD0028 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") medium 0.232 342 no call pass 2549 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL140128 FLD0004 FLD0028 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.090 342 no call QD 260 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL140128 FLD0004 FLD0028 intron TP53 c.96+39G>A chr17 7579661 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579661", "IGV") low 0.102 342 no call QD 186 EXP0116_TP53_E3 ENSG00000141510 3 of 10 74 FFPE AGGTC C/T CCAGC CMDL140128 FLD0004 FLD0028 3_prime_UTR PIK3CA c.*29T>C chr3 178952181 T C =hyperlink("http://localhost:60151/goto?locus=chr3:178952181", "IGV") high 0.363 0.326 2833 2815 pass pass 13781 11294 PIK3CA_Exn21_gap 25834816 ENSG00000121879 21 of 21 rs141178472, COSM249908 C:0.0006 27 FFPE CTCAC T/C CTGGA CMDL140128 FLD0004 FLD0028 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.014 110 QD no call 46 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL140128 FLD0004 FLD0028 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") low 0.205 0.199 1100 1123 QD QD 2100 1633 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140148 FLD0005 FLD0029 intron EGFR c.2284-53C>T chr7 55248933 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248933", "IGV") low 0.081 1161 no call QD 153 EGFR_E00001601336_1 ENSG00000146648 19 of 27 13 FFPE TGCCC C/T TCCTT CMDL140148 FLD0005 FLD0029 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.647 0.465 1426 1094 pass pass 35170 17763 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140148 FLD0005 FLD0029 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.435 0.515 1470 1243 pass pass 21534 23703 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140148 FLD0005 FLD0029 synonymous EGFR c.2508C>T c.2508C>T(p.%3D) cgC/cgT chr7 55259450 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259450", "IGV") high 0.515 0.525 3313 2736 pass pass 35748 29950 EGFR_E00001681524_1 17956637, 21264207, 23093229, 22192147, 23211371, 21869887, 16324836 ENSG00000146648 21 of 28 rs2229066, COSM85893 benign T:0.0054 76 FFPE CACCG C/T GACCT CMDL140148 FLD0005 FLD0029 synonymous EGFR c.2508C>T c.2508C>T(p.%3D) cgC/cgT chr7 55259450 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259450", "IGV") high 0.531 0.501 2272 1559 pass pass 24301 15610 EGFR_E00001681524_2 17956637, 21264207, 23093229, 22192147, 23211371, 21869887, 16324836 ENSG00000146648 21 of 28 rs2229066, COSM85893 benign T:0.0054 34 FFPE CACCG C/T GACCT CMDL140148 FLD0005 FLD0029 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.990 0.997 1734 1482 pass pass 73166 63200 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140148 FLD0005 FLD0029 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.177 609 QD no call 1080 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL140148 FLD0005 FLD0029 nonsynonymous TP53 c.80C>T p.P27L cCt/cTt chr17 7579716 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579716", "IGV") low 0.177 588 no call QD 400 EXP0116_TP53_E3 ENSG00000141510 3 of 11 TP53_g.11202del, COSM85573, COSM296200, COSM296199, COSM296201 tolerated(0.09) benign(0.139) 19 FFPE TTTCA G/A GAAGT CMDL140148 FLD0005 FLD0029 nonsynonymous KRAS c.35G>T p.G12V gGt/gTt chr12 25398284 C A =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") high 0.481 0.382 3625 3140 pass pass 33759 20160 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) possibly_damaging(0.479) 26 FFPE CGCCA C/A CAGCT CMDL140148 FLD0005 FLD0029 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.997 0.995 1862 1765 pass pass 59987 57078 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140148 FLD0005 FLD0029 intron TP53 c.74+36C>T chr17 7579803 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579803", "IGV") low 0.103 1765 no call QD 1395 TP53_E00001596491_1 ENSG00000141510 2 of 10 26 FFPE GGTGG G/A GGTGG CMDL140148 FLD0005 FLD0029 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.997 0.997 1125 1031 pass pass 35064 31902 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140148 FLD0005 FLD0029 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.137 0.160 2985 2019 QD QD 2080 1988 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140156 FLD0006 FLD0030 synonymous EGFR c.2313C>T c.2313C>T(p.%3D) aaC/aaT chr7 55249015 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249015", "IGV") low 0.117 3092 no call QD 1961 EGFR_E00001601336_1 ENSG00000146648 20 of 28 78 FFPE GACAA C/T CCCCA CMDL140156 FLD0006 FLD0030 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.711 0.551 1048 1508 pass pass 28559 30348 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140156 FLD0006 FLD0030 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.637 0.583 1038 1645 pass pass 25772 36616 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140156 FLD0006 FLD0030 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.995 0.992 1226 1810 pass pass 52548 76798 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140156 FLD0006 FLD0030 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.148 501 QD no call 594 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL140156 FLD0006 FLD0030 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.016 105 no call QD 70 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL140156 FLD0006 FLD0030 nonsynonymous PTEN c.374A>G p.K125R aAa/aGa chr10 89692890 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89692890", "IGV") low 0.102 1886 no call QD 182 PTEN_E00001156330_1 ENSG00000171862 5 of 9 COSM1349521, COSM1222443 deleterious(0) probably_damaging(1) 9 FFPE CTGTA A/G AGCTG CMDL140156 FLD0006 FLD0030 nonsynonymous PTEN c.374A>G p.K125R aAa/aGa chr10 89692890 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89692890", "IGV") low 0.096 0.081 1158 1498 QD QD 887 88 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM1349521, COSM1222443 deleterious(0) probably_damaging(1) 27 FFPE CTGTA A/G AGCTG CMDL140156 FLD0006 FLD0030 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.010 0.001 796 1143 QD QD 563 225 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL140156 FLD0006 FLD0030 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.993 0.996 796 1143 QD QD 563 225 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140156 FLD0006 FLD0030 intron TP53 c.74+40C>T chr17 7579799 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579799", "IGV") low 0.113 1964 QD no call 2712 TP53_E00001596491_1 ENSG00000141510 2 of 10 22 FFPE TTGGG G/A TGGGG CMDL140156 FLD0006 FLD0030 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.994 0.993 1964 2173 pass pass 71186 71596 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140156 FLD0006 FLD0030 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.987 0.988 760 1047 pass pass 23985 33226 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140156 FLD0006 FLD0030 3_prime_UTR TP53 c.*50C>T chr17 7572877 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572877", "IGV") medium 0.186 986 pass no call 4271 TP53_E00001757276_1 ENSG00000141510 11 of 11 8 FFPE GGGAG G/A GAGAG CMDL140156 FLD0006 FLD0030 3_prime_UTR TP53 c.*49C>T chr17 7572878 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572878", "IGV") low 0.125 986 QD no call 1766 TP53_E00001757276_1 ENSG00000141510 11 of 11 9 FFPE GGAGG G/A AGAGA CMDL140156 FLD0006 FLD0030 3_prime_UTR TP53 c.*42C>T chr17 7572885 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572885", "IGV") low 0.179 1814 QD no call 3532 TP53_E00001757276_1 ENSG00000141510 11 of 11 16 FFPE GAGAT G/A GGGGT CMDL140156 FLD0006 FLD0030 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.182 2284 no call QD 2837 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140156 FLD0006 FLD0030 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") medium 0.246 2284 no call pass 6683 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL140166 FLD0007 FLD0031 intron EGFR c.2284-30C>T chr7 55248956 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248956", "IGV") medium 0.989 1199 no call pass 50525 EGFR_E00001601336_1 ENSG00000146648 19 of 27 36 FFPE CGAAG C/T CACAC CMDL140166 FLD0007 FLD0031 intron EGFR c.2284-14C>T chr7 55248972 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248972", "IGV") medium 0.995 2000 pass no call 55499 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs776154077 52 FFPE TGCCT C/T TCCCT CMDL140166 FLD0007 FLD0031 synonymous EGFR c.2304C>T c.2304C>T(p.%3D) agC/agT chr7 55249006 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249006", "IGV") medium 0.989 2349 no call pass 68038 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs778199483 86 FFPE GCCAG C/T GTGGA CMDL140166 FLD0007 FLD0031 nonsynonymous EGFR c.2369C>T p.T790M aCg/aTg chr7 55249071 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249071", "IGV") medium 0.995 1154 no call pass 49011 EGFR_E00001601336_1 ENSG00000146648 20 of 28 CM054664, rs121434569, COSM6240 deleterious(0) probably_damaging(1) likely_pathogenic,drug_response,protective 22 FFPE CATCA C/T GCAGC CMDL140166 FLD0007 FLD0031 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.974 0.998 1582 1566 pass pass 64626 68376 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140166 FLD0007 FLD0031 splice_region,intron TP53 c.97-3C>T chr17 7579593 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579593", "IGV") medium 0.205 135 pass no call 367 EXP0116_TP53_E3 ENSG00000141510 3 of 10 17 FFPE GGACT G/A TAGAT CMDL140166 FLD0007 FLD0031 intron TP53 c.96+24G>A chr17 7579676 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579676", "IGV") medium 0.597 1030 no call pass 10455 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE CAGGT C/T CCCAG CMDL140166 FLD0007 FLD0031 splice_region,synonymous TP53 c.96G>A c.96G>A(p.%3D) ctG/ctA chr17 7579700 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579700", "IGV") medium 0.286 1030 no call pass 5122 EXP0116_TP53_E3 ENSG00000141510 3 of 11 35 FFPE CTTAC C/T AGAAC CMDL140166 FLD0007 FLD0031 intron PTEN c.802-39C>T chr10 89720612 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720612", "IGV") low 0.362 87 QD no call 70 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs770794279 73 FFPE TATGT C/T ATTTC CMDL140166 FLD0007 FLD0031 nonsynonymous PTEN c.814C>T p.H272Y Cac/Tac chr10 89720663 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720663", "IGV") low 0.166 101 no call QD 196 PTEN_E00001156315_1m ENSG00000171862 8 of 9 COSM5066 deleterious(0.02) benign(0.145) 22 FFPE TGTTT C/T ACTTT CMDL140166 FLD0007 FLD0031 splice_donor PTEN c.801+1G>A chr10 89717777 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717777", "IGV") medium 0.128 1439 no call pass 2975 PTEN_E00001156321_4m ENSG00000171862 7 of 8 CS002685, CS992481, CD011189, COSM5970 8 FFPE AAAAG G/A TTTGT CMDL140166 FLD0007 FLD0031 intron TP53 c.74+53C>T chr17 7579786 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579786", "IGV") medium 0.128 929 pass no call 2003 TP53_E00001596491_1 ENSG00000141510 2 of 10 9 FFPE TAGGG G/A GCTGG CMDL140166 FLD0007 FLD0031 intron TP53 c.74+49C>T chr17 7579790 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579790", "IGV") medium 0.408 947 pass no call 13380 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs762400295 13 FFPE GGGCT G/A GGGTT CMDL140166 FLD0007 FLD0031 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.995 0.995 1869 2183 pass pass 73131 89499 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140166 FLD0007 FLD0031 intron TP53 c.74+35C>T chr17 7579804 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579804", "IGV") medium 0.322 2183 no call pass 11468 TP53_E00001596491_1 ENSG00000141510 2 of 10 27 FFPE GTGGG G/A GTGGT CMDL140166 FLD0007 FLD0031 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") medium 0.409 0.134 1869 2183 pass QD 21546 253 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL140166 FLD0007 FLD0031 synonymous TP53 c.40C>T c.40C>T(p.%3D) Ctg/Ttg chr17 7579873 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579873", "IGV") medium 0.258 2183 no call pass 5673 TP53_E00001596491_1 ENSG00000141510 2 of 11 50 FFPE ACTCA G/A AGGGG CMDL140166 FLD0007 FLD0031 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.981 0.995 656 620 pass pass 23291 21163 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140166 FLD0007 FLD0031 3_prime_UTR TP53 c.*49C>T chr17 7572878 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572878", "IGV") medium 0.184 1175 pass no call 8452 TP53_E00001757276_1 ENSG00000141510 11 of 11 9 FFPE GGAGG G/A AGAGA CMDL140166 FLD0007 FLD0031 3_prime_UTR TP53 c.*41C>T chr17 7572886 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572886", "IGV") high 0.235 0.269 2386 2922 pass pass 8992 18339 TP53_E00001757276_1 ENSG00000141510 11 of 11 17 FFPE AGATG G/A GGGTG CMDL140166 FLD0007 FLD0031 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.185 2386 pass no call 7448 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140166 FLD0007 FLD0031 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") low 0.140 2922 no call QD 3656 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL140166 FLD0007 FLD0031 3_prime_UTR TP53 c.*20C>T chr17 7572907 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572907", "IGV") low 0.158 2922 no call QD 4693 TP53_E00001757276_1 ENSG00000141510 11 of 11 38 FFPE AGTGG G/A GAACA CMDL140167 FLD0008 FLD0032 intron EGFR c.2284-22A>G chr7 55248964 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55248964", "IGV") low 0.158 3766 QD no call 2933 EGFR_E00001601336_1 ENSG00000146648 19 of 27 44 FFPE CACTG A/G CGTGC CMDL140167 FLD0008 FLD0032 nonsynonymous EGFR c.2300C>T p.A767V gCc/gTc chr7 55249002 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249002", "IGV") medium 0.192 3766 pass no call 8933 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs397517107, COSM26445 deleterious(0) probably_damaging(1) uncertain_significance 82 FFPE GATGG C/T CAGCG CMDL140167 FLD0008 FLD0032 nonsynonymous EGFR c.2323T>C p.C775R Tgc/Cgc chr7 55249025 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55249025", "IGV") medium 0.194 3766 pass no call 19500 EGFR_E00001601336_1 ENSG00000146648 20 of 28 tolerated(0.06) probably_damaging(0.998) 68 FFPE ACGTG T/C GCCGC CMDL140167 FLD0008 FLD0032 synonymous EGFR c.2343C>T c.2343C>T(p.%3D) tgC/tgT chr7 55249045 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249045", "IGV") medium 0.194 3766 pass no call 19770 EGFR_E00001601336_1 ENSG00000146648 20 of 28 48 FFPE ATCTG C/T CTCAC CMDL140167 FLD0008 FLD0032 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") medium 0.982 1834 pass no call 78465 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140167 FLD0008 FLD0032 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.638 0.653 1815 1533 pass pass 46869 39135 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140167 FLD0008 FLD0032 nonsynonymous EGFR c.2596G>A p.E866K Gag/Aag chr7 55259538 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259538", "IGV") low 0.143 2007 no call QD 475 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs756703787, COSM13198 deleterious(0) probably_damaging(0.982) 34 FFPE CGGAA G/A AGAAA CMDL140167 FLD0008 FLD0032 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.997 0.997 1942 1655 pass pass 83877 70587 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140167 FLD0008 FLD0032 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.992 0.993 4553 3706 pass pass 154340 115277 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL140167 FLD0008 FLD0032 intron TP53 c.97-32G>A chr17 7579622 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579622", "IGV") medium 0.528 363 no call pass 4865 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs754228616 46 FFPE GAGGA C/T CAGGT CMDL140167 FLD0008 FLD0032 intron TP53 c.97-44G>A chr17 7579634 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579634", "IGV") medium 0.290 363 no call pass 755 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs762445877 58 FFPE CTCAG C/T CCCCC CMDL140167 FLD0008 FLD0032 stop_gained PIK3CA c.1656G>A p.W552* tgG/tgA chr3 178936114 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936114", "IGV") medium 0.164 939 no call pass 2650 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM37025, COSM86991 13 FFPE CTATG G/A AGTCA CMDL140167 FLD0008 FLD0032 nonsynonymous PIK3CA c.1660C>T p.H554Y Cac/Tac chr3 178936118 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178936118", "IGV") medium 0.163 1286 pass no call 4428 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM1651761 tolerated(1) benign(0.342) 9 FFPE GGAGT C/T ACAGG CMDL140167 FLD0008 FLD0032 intron PTEN c.802-162C>T chr10 89720489 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720489", "IGV") low 0.163 1225 no call QD 1415 PTEN_E00001156315_1m ENSG00000171862 7 of 8 9 FFPE ATAGT C/T TTTGT CMDL140167 FLD0008 FLD0032 intron PTEN c.802-118T>C chr10 89720533 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720533", "IGV") low 0.106 1225 no call QD 1895 PTEN_E00001156315_1m ENSG00000171862 7 of 8 53 FFPE TATTT T/C GTTGA CMDL140167 FLD0008 FLD0032 intron PTEN c.802-83G>A chr10 89720568 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720568", "IGV") medium 0.260 1935 pass no call 9975 PTEN_E00001156315_1m ENSG00000171862 7 of 8 88 FFPE TGACA G/A ATTTT CMDL140167 FLD0008 FLD0032 intron PTEN c.802-11T>C chr10 89720640 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720640", "IGV") medium 0.101 460 pass no call 3084 PTEN_E00001156315_1m ENSG00000171862 7 of 8 45 FFPE TTTTT T/C TTTTT CMDL140167 FLD0008 FLD0032 splice_region,intron PTEN c.802-7T>G chr10 89720644 T G =hyperlink("http://localhost:60151/goto?locus=chr10:89720644", "IGV") medium 0.110 460 pass no call 4718 PTEN_E00001156315_1m ENSG00000171862 7 of 8 41 FFPE TTTTT T/G TTTTA CMDL140167 FLD0008 FLD0032 nonsynonymous PTEN c.901G>A p.D301N Gat/Aat chr10 89720750 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720750", "IGV") low 0.125 2641 QD no call 4429 PTEN_E00001156315_7 ENSG00000171862 8 of 9 rs758644748, COSM921144 tolerated(0.35) benign(0.002) 18 FFPE AAATC G/A ATAGC CMDL140167 FLD0008 FLD0032 splice_donor PTEN c.1026+1G>A chr10 89720876 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720876", "IGV") medium 0.187 2440 pass no call 9897 PTEN_E00001156315_7 ENSG00000171862 8 of 8 rs398123313, CS110216, CS043794, COSM3441286, COSM5957, COSM5978, COSM19564 uncertain_significance 20 FFPE TTAAG G/A TCAGT CMDL140167 FLD0008 FLD0032 intron PTEN c.801+129G>A chr10 89717905 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717905", "IGV") low 0.097 1484 no call QD 676 PTEN_E00001156321_4m ENSG00000171862 7 of 8 29 FFPE ACTCT G/A GCATT CMDL140167 FLD0008 FLD0032 nonsynonymous PTEN c.536G>A p.S179N aGc/aAc chr10 89711918 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89711918", "IGV") low 0.100 1769 no call QD 1810 PTEN_E00001156327_4 ENSG00000171862 6 of 9 COSM5249 tolerated(0.38) benign(0.002) 10 FFPE TTATA G/A CTACC CMDL140167 FLD0008 FLD0032 intron PTEN c.634+30G>A chr10 89712046 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89712046", "IGV") low 0.113 1607 QD no call 2032 PTEN_E00001156327_4 ENSG00000171862 6 of 8 4 FFPE TCCAT G/A TATTG CMDL140167 FLD0008 FLD0032 nonsynonymous PTEN c.352C>T p.H118Y Cat/Tat chr10 89692868 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692868", "IGV") medium 0.160 1644 pass no call 5127 PTEN_E00001156330_3 ENSG00000171862 5 of 9 deleterious(0) benign(0.309) 5 FFPE ACAAT C/T ATGTT CMDL140167 FLD0008 FLD0032 nonsynonymous PTEN c.356T>C p.V119A gTt/gCt chr10 89692872 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89692872", "IGV") low 0.092 1399 no call QD 427 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5215, COSM1349517 deleterious(0.04) possibly_damaging(0.85) 9 FFPE TCATG T/C TGCAG CMDL140167 FLD0008 FLD0032 synonymous PTEN c.369C>T c.369C>T(p.%3D) caC/caT chr10 89692885 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692885", "IGV") medium 0.166 1399 no call pass 5271 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CM1010010 22 FFPE ATTCA C/T TGTAA CMDL140167 FLD0008 FLD0032 nonsynonymous PTEN c.385G>A p.G129R Gga/Aga chr10 89692901 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692901", "IGV") high 0.988 0.989 3345 2787 pass pass 109730 90007 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM246853, COSM18663, COSM5092 deleterious(0) probably_damaging(1) 38 FFPE GAAAG G/A GACGA CMDL140167 FLD0008 FLD0032 intron PTEN c.492+15G>A chr10 89693023 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89693023", "IGV") medium 0.145 1388 no call pass 3194 PTEN_E00001156330_3 ENSG00000171862 5 of 8 2 FFPE TTTTT G/A ATGTT CMDL140167 FLD0008 FLD0032 intron PTEN c.165-64G>A chr10 89685206 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89685206", "IGV") low 0.083 1972 QD no call 266 PTEN_E00001156344_1 ENSG00000171862 2 of 8 7 FFPE TTAAT G/A TAATT CMDL140167 FLD0008 FLD0032 intron PTEN c.209+14C>T chr10 89685328 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89685328", "IGV") low 0.077 1742 no call LowQual,QD 10 PTEN_E00001156344_1 ENSG00000171862 3 of 8 rs773955737 11 FFPE GTTTT C/T TTATT CMDL140167 FLD0008 FLD0032 nonsynonymous PTEN c.113C>T p.P38L cCt/cTt chr10 89653815 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653815", "IGV") low 0.224 3518 no call QD 6585 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM249828, COSM3736937 deleterious(0) probably_damaging(0.997) 48 FFPE ATTTC C/T TGCAG CMDL140167 FLD0008 FLD0032 synonymous PTEN c.150T>C c.150T>C(p.%3D) atT/atC chr10 89653852 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89653852", "IGV") low 0.178 4143 QD no call 3808 PTEN_E00001156351_1 ENSG00000171862 2 of 9 CD110172 45 FFPE AATAT T/C GATGA CMDL140167 FLD0008 FLD0032 intron PTEN c.164+23T>C chr10 89653889 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89653889", "IGV") low 0.100 2076 QD no call 632 PTEN_E00001156351_1 ENSG00000171862 2 of 8 8 FFPE TTCTA T/C TTCAA CMDL140167 FLD0008 FLD0032 intron PTEN c.164+24T>C chr10 89653890 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89653890", "IGV") medium 0.144 1767 no call pass 3712 PTEN_E00001156351_1 ENSG00000171862 2 of 8 7 FFPE TCTAT T/C TCAAA CMDL140167 FLD0008 FLD0032 5_prime_UTR PTEN c.-15C>T chr10 89624212 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624212", "IGV") low 0.090 1643 QD no call 798 PTEN_E00001456562_1 ENSG00000171862 1 of 9 18 FFPE TCAGC C/T ACAGG CMDL140167 FLD0008 FLD0032 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.999 1404 no call pass 59208 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140167 FLD0008 FLD0032 intron TP53 c.74+41C>T chr17 7579798 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579798", "IGV") medium 0.230 573 no call pass 1254 TP53_E00001596491_1 ENSG00000141510 2 of 10 21 FFPE GTTGG G/A GTGGG CMDL140167 FLD0008 FLD0032 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.537 0.845 460 573 pass pass 4854 15691 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140167 FLD0008 FLD0032 synonymous TP53 c.45T>C c.45T>C(p.%3D) agT/agC chr17 7579868 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7579868", "IGV") low 0.219 573 no call QD 997 TP53_E00001596491_1 ENSG00000141510 2 of 11 rs766765429 55 FFPE TCCTG A/G CTCAG CMDL140167 FLD0008 FLD0032 nonsynonymous TP53 c.296C>T p.S99F tCc/tTc chr17 7579391 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579391", "IGV") low 0.138 228 QD no call 133 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11527C>T, COSM44036 deleterious(0.01) probably_damaging(0.978) 14 FFPE TCTGG G/A AAGGG CMDL140167 FLD0008 FLD0032 synonymous TP53 c.267C>T c.267C>T(p.%3D) ccC/ccT chr17 7579420 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579420", "IGV") low 0.172 176 no call QD 245 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs587783062, TP53_g.11498C>T, TP53_g.11498del, COSM1268330, COSM1180853, COSM1180854 likely_pathogenic 43 FFPE CAGGA G/A GGGGC CMDL140167 FLD0008 FLD0032 nonsynonymous TP53 c.265C>T p.P89S Ccc/Tcc chr17 7579422 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579422", "IGV") low 0.081 228 QD no call 145 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11496C>T, TP53_g.11496del, COSM43688, COSM46063 tolerated(0.52) benign(0.017) 45 FFPE GGAGG G/A GGCTG CMDL140167 FLD0008 FLD0032 nonsynonymous TP53 c.253C>T p.P85S Cct/Tct chr17 7579434 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579434", "IGV") low 0.081 228 QD no call 149 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11484del, TP53_g.11484C>T, COSM45918 tolerated(0.51) benign(0.019) 57 FFPE TGCAG G/A GGCCG CMDL140167 FLD0008 FLD0032 synonymous TP53 c.252C>T c.252C>T(p.%3D) gcC/gcT chr17 7579435 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579435", "IGV") low 0.183 176 no call QD 240 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs549892645, TP53_g.11483C>T, COSM45512 58 FFPE GCAGG G/A GCCGC CMDL140167 FLD0008 FLD0032 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.715 0.892 228 176 pass pass 4130 4096 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140167 FLD0008 FLD0032 synonymous TP53 c.684C>T c.684C>T(p.%3D) gaC/gaT chr17 7577597 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577597", "IGV") low 0.081 1504 no call QD 211 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13321C>T, TP53_g.13321del, TP53_g.13321C>A, TP53_g.13321C>G, COSM43853, COSM45028, COSM44323, COSM46075 15 FFPE GTACA G/A TCAGA CMDL140167 FLD0008 FLD0032 nonsynonymous TP53 c.1010G>A p.R337H cGc/cAc chr17 7574017 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7574017", "IGV") low 0.082 1256 no call QD 208 TP53_E00001728015_1 ENSG00000141510 10 of 11 CM012663, CM104660, TP53_g.16901G>A, TP53_g.16901G>T, TP53_g.16901G>C, COSM43882, COSM11411, COSM378685, COSM378686, COSM220135, COSM131485 tolerated(0.09) probably_damaging(0.975) 20 FFPE CGAAG C/T GCTCA CMDL140167 FLD0008 FLD0032 3_prime_UTR TP53 c.*50C>T chr17 7572877 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572877", "IGV") low 0.080 1768 QD no call 281 TP53_E00001757276_1 ENSG00000141510 11 of 11 8 FFPE GGGAG G/A GAGAG CMDL140167 FLD0008 FLD0032 3_prime_UTR TP53 c.*41C>T chr17 7572886 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572886", "IGV") medium 0.207 3086 pass no call 9585 TP53_E00001757276_1 ENSG00000141510 11 of 11 17 FFPE AGATG G/A GGGTG CMDL140167 FLD0008 FLD0032 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.447 2668 no call pass 28396 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140167 FLD0008 FLD0032 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.454 2668 no call pass 28948 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140167 FLD0008 FLD0032 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") medium 0.334 3086 pass no call 18553 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL140167 FLD0008 FLD0032 nonsynonymous TP53 c.1160C>T p.T387I aCa/aTa chr17 7572949 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572949", "IGV") medium 0.330 3086 pass no call 15272 TP53_E00001757276_1 ENSG00000141510 11 of 11 tolerated(0.07) benign(0.081) 62 FFPE CTTCT G/A TCTTG CMDL140167 FLD0008 FLD0032 nonsynonymous TP53 c.1135C>T p.R379C Cgc/Tgc chr17 7572974 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572974", "IGV") medium 0.406 2668 no call pass 19749 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs749061599 tolerated(0.17) benign(0.005) uncertain_significance 37 FFPE ATGGC G/A GGAGG CMDL140167 FLD0008 FLD0032 intron TP53 c.920-17C>T chr17 7576943 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576943", "IGV") low 0.114 2310 no call QD 3607 TP53_E00001789298_1 ENSG00000141510 8 of 10 21 FFPE GCAAG G/A AAAGG CMDL140167 FLD0008 FLD0032 intron TP53 c.920-21C>T chr17 7576947 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576947", "IGV") low 0.077 2309 no call QD 255 TP53_E00001789298_1 ENSG00000141510 8 of 10 TP53_g.13971C>T, COSM45556 17 FFPE GGAAA G/A GTGAT CMDL140185 FLD0009 FLD0033 intron EGFR c.2284-54C>T chr7 55248932 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248932", "IGV") medium 0.194 1353 pass no call 6214 EGFR_E00001601336_1 ENSG00000146648 19 of 27 12 FFPE GTGCC C/T CTCCT CMDL140185 FLD0009 FLD0033 nonsynonymous EGFR c.2314C>T p.P772S Ccc/Tcc chr7 55249016 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249016", "IGV") medium 0.984 2465 no call pass 69730 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs746677478 deleterious(0) probably_damaging(0.95) 77 FFPE ACAAC C/T CCCAC CMDL140185 FLD0009 FLD0033 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") medium 0.987 1199 no call pass 50274 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140185 FLD0009 FLD0033 synonymous EGFR c.2337C>T c.2337C>T(p.%3D) ggC/ggT chr7 55249039 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249039", "IGV") low 0.087 1541 no call QD 799 EGFR_E00001601336_2 ENSG00000146648 20 of 28 18 FFPE CTGGG C/T ATCTG CMDL140185 FLD0009 FLD0033 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.528 0.548 1624 1589 pass pass 31211 31336 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140185 FLD0009 FLD0033 nonsynonymous,splice_region EGFR c.2470G>A p.G824S Ggc/Agc chr7 55259412 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259412", "IGV") medium 0.251 3787 no call pass 9063 EGFR_E00001681524_1 ENSG00000146648 21 of 28 deleterious(0.02) probably_damaging(0.997) 41 FFPE TTCAG G/A GCATG CMDL140185 FLD0009 FLD0033 synonymous EGFR c.2484G>A c.2484G>A(p.%3D) ttG/ttA chr7 55259426 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259426", "IGV") low 0.096 1112 no call QD 812 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs727504312, COSM3639750 likely_benign 10 FFPE TACTT G/A GAGGA CMDL140185 FLD0009 FLD0033 nonsynonymous EGFR c.2617G>A p.G873R Gga/Aga chr7 55259559 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259559", "IGV") low 0.094 1045 no call QD 713 EGFR_E00001681524_2 ENSG00000146648 21 of 28 deleterious(0) probably_damaging(0.997) 13 FFPE CAGAA G/A GAGGC CMDL140185 FLD0009 FLD0033 intron EGFR c.2702-22T>C chr7 55266388 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266388", "IGV") low 0.107 1443 QD no call 1050 EGFR_E00001779947_1 ENSG00000146648 22 of 27 rs767633888 5 FFPE CCTTC T/C TTTCT CMDL140185 FLD0009 FLD0033 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.997 0.995 1446 1815 pass pass 62079 78288 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140185 FLD0009 FLD0033 nonsynonymous EGFR c.2804A>G p.Q935R cAg/cGg chr7 55266512 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55266512", "IGV") low 0.108 1487 QD no call 263 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(0.999) 40 FFPE CCCTC A/G GCCAC CMDL140185 FLD0009 FLD0033 synonymous EGFR c.2820C>T c.2820C>T(p.%3D) acC/acT chr7 55266528 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266528", "IGV") low 0.107 1810 no call QD 1141 EGFR_E00001779947_1 ENSG00000146648 23 of 28 COSM3639754 24 FFPE TGTAC C/T ATCGA CMDL140185 FLD0009 FLD0033 nonsynonymous EGFR c.2830T>C p.Y944H Tac/Cac chr7 55266538 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266538", "IGV") low 0.085 1447 QD no call 805 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0.01) probably_damaging(1) 14 FFPE ATGTC T/C ACATG CMDL140185 FLD0009 FLD0033 synonymous EGFR c.2832C>T c.2832C>T(p.%3D) taC/taT chr7 55266540 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266540", "IGV") low 0.087 1447 QD no call 1021 EGFR_E00001779947_1 ENSG00000146648 23 of 28 12 FFPE GTCTA C/T ATGAT CMDL140185 FLD0009 FLD0033 intron TP53 c.96+21G>A chr17 7579679 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579679", "IGV") medium 0.948 220 pass no call 3596 EXP0116_TP53_E3 ENSG00000141510 3 of 10 56 FFPE GTCCC C/T AGCCC CMDL140185 FLD0009 FLD0033 splice_acceptor PIK3CA c.1540-1G>A chr3 178935997 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178935997", "IGV") low 0.118 1018 no call QD 1757 PIK3CA_Ex10_gap ENSG00000121879 9 of 20 COSM1726693, COSM1726692 33 FFPE TTACA G/A AGTAA CMDL140185 FLD0009 FLD0033 nonsynonymous PIK3CA c.1612G>A p.D538N Gat/Aat chr3 178936070 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936070", "IGV") medium 0.355 948 pass no call 5650 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM21467, COSM1716811, COSM729821 deleterious(0) probably_damaging(1) 57 FFPE CACGA G/A ATCCT CMDL140185 FLD0009 FLD0033 nonsynonymous PIK3CA c.1633G>A p.E545K Gag/Aag chr3 178936091 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936091", "IGV") high 0.982 0.609 948 2039 pass pass 32325 26264 PIK3CA_Ex10_gap 21264207 ENSG00000121879 10 of 21 rs104886003, COSM763, COSM27133, COSM125370, COSM295672 deleterious(0.02) probably_damaging(0.959) not_provided,pathogenic 36 FFPE TCACT G/A AGCAG CMDL140185 FLD0009 FLD0033 nonsynonymous PIK3CA c.1639G>A p.E547K Gag/Aag chr3 178936097 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936097", "IGV") medium 0.202 1024 no call pass 5026 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM29315, COSM1420863, COSM4115419, COSM1420862 deleterious(0.01) probably_damaging(0.989) 30 FFPE AGCAG G/A AGAAA CMDL140185 FLD0009 FLD0033 intron PTEN c.802-102A>G chr10 89720549 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89720549", "IGV") low 0.093 1281 no call QD 863 PTEN_E00001156315_1m ENSG00000171862 7 of 8 69 FFPE TGCAA A/G TGTTT CMDL140185 FLD0009 FLD0033 intron PTEN c.802-64A>G chr10 89720587 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89720587", "IGV") low 0.129 1041 QD no call 425 PTEN_E00001156315_1m ENSG00000171862 7 of 8 98 FFPE AAAAA A/G TAAAA CMDL140185 FLD0009 FLD0033 splice_region,synonymous PTEN c.804C>T c.804C>T(p.%3D) gaC/gaT chr10 89720653 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720653", "IGV") low 0.132 61 pass no call 647 PTEN_E00001156315_1m ENSG00000171862 8 of 9 rs398123328 not_provided 32 FFPE TAGGA C/T AAAAT CMDL140185 FLD0009 FLD0033 nonsynonymous PTEN c.905G>A p.S302N aGc/aAc chr10 89720754 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720754", "IGV") medium 0.268 2267 pass no call 17797 PTEN_E00001156315_7 ENSG00000171862 8 of 9 rs745638189 tolerated(0.23) benign(0.011) 22 FFPE CGATA G/A CATTT CMDL140185 FLD0009 FLD0033 nonsynonymous PTEN c.970G>A p.D324N Gat/Aat chr10 89720819 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720819", "IGV") low 0.199 4562 QD no call 7570 PTEN_E00001156315_7 ENSG00000171862 8 of 9 tolerated(0.13) benign(0.056) 77 FFPE AAAAT G/A ATCTT CMDL140185 FLD0009 FLD0033 nonsynonymous PTEN c.736C>T p.P246S Ccg/Tcg chr10 89717711 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717711", "IGV") low 0.183 3382 no call QD 3487 PTEN_E00001156321_2 ENSG00000171862 7 of 9 tolerated(0.18) benign(0.06) 65 FFPE CTCAG C/T CGTTA CMDL140185 FLD0009 FLD0033 intron PTEN c.801+127C>T chr10 89717903 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717903", "IGV") medium 0.154 1315 no call pass 3673 PTEN_E00001156321_4m ENSG00000171862 7 of 8 31 FFPE TTACT C/T TGGCA CMDL140185 FLD0009 FLD0033 intron PTEN c.801+135G>A chr10 89717911 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717911", "IGV") low 0.114 1513 QD no call 2124 PTEN_E00001156321_4m ENSG00000171862 7 of 8 23 FFPE GCATT G/A GTGAG CMDL140185 FLD0009 FLD0033 synonymous PTEN c.556C>T c.556C>T(p.%3D) Ctg/Ttg chr10 89711938 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711938", "IGV") low 0.103 3755 QD no call 1787 PTEN_E00001156327_4 ENSG00000171862 6 of 9 30 FFPE ATCAT C/T TGGAT CMDL140185 FLD0009 FLD0033 nonsynonymous PTEN c.581T>C p.L194S tTg/tCg chr10 89711963 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89711963", "IGV") low 0.108 3755 QD no call 1918 PTEN_E00001156327_4 ENSG00000171862 6 of 9 deleterious(0.03) benign(0.296) 55 FFPE ACTGT T/C GTTTC CMDL140185 FLD0009 FLD0033 nonsynonymous PTEN c.386G>A p.G129E gGa/gAa chr10 89692902 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692902", "IGV") medium 0.220 3017 no call pass 6168 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CM971272, CM115947, rs121909218, COSM5276, COSM28917 deleterious(0) probably_damaging(0.998) pathogenic 39 FFPE AAAGG G/A ACGAA CMDL140185 FLD0009 FLD0033 nonsynonymous PTEN c.389G>A p.R130Q cGa/cAa chr10 89692905 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692905", "IGV") low 0.140 3383 QD no call 434 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CM991081, rs121909229, rs121913292, CM981670, COSM5817, COSM5033, COSM5277, COSM5216 deleterious(0.02) probably_damaging(0.989) likely_pathogenic,pathogenic,pathogenic 42 FFPE GGGAC G/A AACTG CMDL140185 FLD0009 FLD0033 nonsynonymous TP53 c.472C>T p.R158C Cgc/Tgc chr17 7578458 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578458", "IGV") low 0.092 3349 QD no call 522 TP53_E00001255919_5 ENSG00000141510 5 of 11 rs587780068, CM004341, TP53_g.12460del, TP53_g.12460C>G, TP53_g.12460C>T, TP53_g.12460C>A, COSM43848, COSM43781, COSM11087, COSM3970361, COSM318152, COSM984954, COSM3970360, COSM984956, COSM3970364, COSM318151, COSM984958, COSM3970366, COSM318153, COSM3970359, COSM3970363, COSM3932746, COSM3970362, COSM2744899, COSM1750371, COSM984957, COSM318154, COSM3970365 deleterious(0) probably_damaging(0.996) 51 FFPE GGCGC G/A GACGC CMDL140185 FLD0009 FLD0033 nonsynonymous TP53 c.396G>C p.K132N aaG/aaC chr17 7578534 C G =hyperlink("http://localhost:60151/goto?locus=chr17:7578534", "IGV") high 0.373 0.385 2166 3328 pass pass 15312 27368 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12384G>A, TP53_g.12384G>T, TP53_g.12384G>C, TP53_g.12384del, COSM10991, COSM43963, COSM45680, COSM44632, COSM301221, COSM213187, COSM301220, COSM213186, COSM3403291, COSM3726808, COSM2157115, COSM1750373, COSM301222, COSM213188 deleterious(0) probably_damaging(1) 40 FFPE AACAT C/G TTGTT CMDL140185 FLD0009 FLD0033 intron TP53 c.74+47C>A chr17 7579792 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579792", "IGV") medium 0.576 2379 no call pass 28575 TP53_E00001596491_1 ENSG00000141510 2 of 10 15 FFPE GCTGG G/T GTTGG CMDL140185 FLD0009 FLD0033 intron TP53 c.74+43C>T chr17 7579796 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579796", "IGV") medium 0.322 2435 pass no call 12936 TP53_E00001596491_1 ENSG00000141510 2 of 10 19 FFPE GGGTT G/A GGGTG CMDL140185 FLD0009 FLD0033 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.995 0.995 2435 2379 pass pass 100795 95029 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140185 FLD0009 FLD0033 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") medium 0.404 2435 pass no call 18696 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL140185 FLD0009 FLD0033 nonsynonymous TP53 c.265C>T p.P89S Ccc/Tcc chr17 7579422 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579422", "IGV") low 0.083 452 QD no call 98 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11496C>T, TP53_g.11496del, COSM43688, COSM46063 tolerated(0.52) benign(0.017) 45 FFPE GGAGG G/A GGCTG CMDL140185 FLD0009 FLD0033 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.992 0.993 452 400 pass pass 17008 13767 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140185 FLD0009 FLD0033 intron TP53 c.1100+30A>T chr17 7573897 T A =hyperlink("http://localhost:60151/goto?locus=chr17:7573897", "IGV") high 0.774 0.808 1078 1301 pass pass 32768 40313 TP53_E00001728015_1 22829934 ENSG00000141510 10 of 10 rs17880847, TP53_g.17021A>T, COSM45239 A:0.0032 17 FFPE GGGAG T/A AGGGC CMDL140185 FLD0009 FLD0033 intron TP53 c.1100+26C>T chr17 7573901 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573901", "IGV") low 0.129 1081 QD no call 1375 TP53_E00001728015_1 ENSG00000141510 10 of 10 rs780532950 21 FFPE GTAGG G/A CCAGG CMDL140185 FLD0009 FLD0033 3_prime_UTR TP53 c.*51C>T chr17 7572876 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572876", "IGV") medium 0.320 1712 pass no call 19606 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs760698953 7 FFPE GGGGA G/A GGAGA CMDL140185 FLD0009 FLD0033 3_prime_UTR TP53 c.*50C>T chr17 7572877 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572877", "IGV") medium 0.321 1712 pass no call 19612 TP53_E00001757276_1 ENSG00000141510 11 of 11 8 FFPE GGGAG G/A GAGAG CMDL140185 FLD0009 FLD0033 3_prime_UTR TP53 c.*45C>T chr17 7572882 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572882", "IGV") medium 0.319 3158 pass no call 37997 TP53_E00001757276_1 ENSG00000141510 11 of 11 13 FFPE GGAGA G/A ATGGG CMDL140185 FLD0009 FLD0033 3_prime_UTR TP53 c.*41C>T chr17 7572886 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572886", "IGV") high 0.416 0.477 3158 3528 pass pass 44433 37448 TP53_E00001757276_1 ENSG00000141510 11 of 11 17 FFPE AGATG G/A GGGTG CMDL140185 FLD0009 FLD0033 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.319 3158 pass no call 16485 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140185 FLD0009 FLD0033 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") medium 0.622 3528 no call pass 53542 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL140185 FLD0009 FLD0033 3_prime_UTR TP53 c.*34C>T chr17 7572893 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572893", "IGV") low 0.101 3158 QD no call 2195 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs545818827 A:0.0002 24 FFPE GGTGG G/A AGGCT CMDL140185 FLD0009 FLD0033 3_prime_UTR TP53 c.*8C>T chr17 7572919 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572919", "IGV") medium 0.304 3158 pass no call 15253 TP53_E00001757276_1 ENSG00000141510 11 of 11 50 FFPE GAAGT G/A GAGAA CMDL140185 FLD0009 FLD0033 3_prime_UTR TP53 c.*5C>T chr17 7572922 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572922", "IGV") medium 0.298 3158 pass no call 15335 TP53_E00001757276_1 ENSG00000141510 11 of 11 53 FFPE GTGGA G/A AATGT CMDL140185 FLD0009 FLD0033 nonsynonymous TP53 c.1112C>T p.S371F tCc/tTc chr17 7572997 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572997", "IGV") medium 0.295 3158 pass no call 13604 TP53_E00001757276_1 ENSG00000141510 11 of 11 deleterious(0.01) possibly_damaging(0.602) 14 FFPE TTTTG G/A ACTTC CMDL140185 FLD0009 FLD0033 intron TP53 c.993+30G>A chr17 7576823 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576823", "IGV") low 0.117 2343 QD no call 2757 TP53_E00001789298_1 ENSG00000141510 9 of 10 17 FFPE CTTTC C/T ACTTG CMDL140192 FLD0010 FLD0034 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.435 0.438 1459 1626 pass pass 21598 24118 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140192 FLD0010 FLD0034 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.494 0.468 1462 1531 pass pass 26108 25115 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140192 FLD0010 FLD0034 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.993 0.991 1623 1597 pass pass 69236 67757 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140192 FLD0010 FLD0034 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.130 1153 QD no call 1026 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL140192 FLD0010 FLD0034 intron TP53 c.96+30G>A chr17 7579670 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579670", "IGV") low 0.164 1153 QD no call 1460 EXP0116_TP53_E3 ENSG00000141510 3 of 10 65 FFPE GCCCT C/T CAGGT CMDL140192 FLD0010 FLD0034 synonymous TP53 c.639A>G c.639A>G(p.%3D) cgA/cgG chr17 7578210 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578210", "IGV") high 0.621 0.651 2610 2533 pass pass 37812 38677 TP53_E00001255919_1 20455025, 18798306, 15450681, 23543587, 24218030, 22829934, 18594532, 21869887, 17133269 ENSG00000141510 6 of 11 CX984230, rs1800372, TP53_g.12708A>T, COSM249885, COSM1741221, COSM1741223, COSM1741225, COSM3755916, COSM1741222, COSM1741224 benign C:0.0054 43 FFPE CTATG T/C CGAAA CMDL140192 FLD0010 FLD0034 nonsynonymous TP53 c.578A>G p.H193R cAt/cGt chr17 7578271 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578271", "IGV") high 0.563 0.595 4034 3816 pass pass 49687 49764 TP53_E00001255919_3 ENSG00000141510 6 of 11 CM083194, CM951225, TP53_g.12647A>T, TP53_g.12647A>C, TP53_g.12647A>G, COSM10742, COSM11066, COSM43833, COSM308307, COSM99919, COSM131458, COSM131459, COSM99916, COSM308306, COSM99917, COSM308308, COSM131461, COSM3820719, COSM3970355, COSM3732881, COSM1740322, COSM2744772, COSM3970354, COSM308309, COSM131460, COSM99918 deleterious(0) probably_damaging(1) 22 FFPE TAAGA T/C GCTGA CMDL140192 FLD0010 FLD0034 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") high 0.129 0.147 1010 1080 pass pass 2019 2725 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL140192 FLD0010 FLD0034 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") low 0.090 1010 QD no call 310 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL140192 FLD0010 FLD0034 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.996 0.995 2040 2171 pass pass 74010 76873 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140192 FLD0010 FLD0034 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") low 0.150 0.131 2040 2171 QD QD 440 71 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL140192 FLD0010 FLD0034 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.994 0.997 1217 1165 pass pass 37764 37893 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140192 FLD0010 FLD0034 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.150 3249 QD no call 2184 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140192 FLD0010 FLD0034 3_prime_UTR TP53 c.*36C>T chr17 7572891 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572891", "IGV") low 0.141 3249 QD no call 4526 TP53_E00001757276_1 ENSG00000141510 11 of 11 22 FFPE GGGGT G/A GGAGG CMDL140200 FLD0011 FLD0035 intron EGFR c.2284-55C>T chr7 55248931 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248931", "IGV") medium 0.145 1716 no call pass 4407 EGFR_E00001601336_1 ENSG00000146648 19 of 27 11 FFPE TGTGC C/T CCTCC CMDL140200 FLD0011 FLD0035 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.451 0.580 1672 1638 pass pass 25907 34670 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140200 FLD0011 FLD0035 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.507 0.521 1633 1552 pass pass 29459 30355 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140200 FLD0011 FLD0035 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.471 0.559 1693 1683 pass pass 28028 34066 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140200 FLD0011 FLD0035 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.470 0.490 3641 3581 pass pass 31717 33076 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL140200 FLD0011 FLD0035 intron TP53 c.97-45G>A chr17 7579635 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579635", "IGV") medium 0.109 1060 no call pass 2338 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE TCAGC C/T CCCCA CMDL140200 FLD0011 FLD0035 intron TP53 c.97-48G>A chr17 7579638 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579638", "IGV") medium 0.105 1060 no call pass 2346 EXP0116_TP53_E3 ENSG00000141510 3 of 10 62 FFPE GCCCC C/T CAGCC CMDL140200 FLD0011 FLD0035 intron TP53 c.96+33G>A chr17 7579667 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579667", "IGV") low 0.075 1098 QD no call 321 EXP0116_TP53_E3 ENSG00000141510 3 of 10 68 FFPE CCAGC C/T CTCCA CMDL140200 FLD0011 FLD0035 intron TP53 c.96+30G>A chr17 7579670 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579670", "IGV") low 0.082 1098 QD no call 338 EXP0116_TP53_E3 ENSG00000141510 3 of 10 65 FFPE GCCCT C/T CAGGT CMDL140200 FLD0011 FLD0035 intron TP53 c.96+23G>A chr17 7579677 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579677", "IGV") low 0.193 1098 QD no call 623 EXP0116_TP53_E3 ENSG00000141510 3 of 10 58 FFPE AGGTC C/T CCAGC CMDL140200 FLD0011 FLD0035 splice_region,intron TP53 c.96+5G>A chr17 7579695 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579695", "IGV") low 0.116 1098 QD no call 1782 EXP0116_TP53_E3 ENSG00000141510 3 of 10 40 FFPE TTGTC C/T TTACC CMDL140200 FLD0011 FLD0035 nonsynonymous PIK3CA c.1625A>T p.E542V gAa/gTa chr3 178936083 A T =hyperlink("http://localhost:60151/goto?locus=chr3:178936083", "IGV") high 0.398 0.424 1966 1961 pass pass 13921 14789 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM762, COSM1041495, COSM761, COSM1041493, COSM1041494, COSM446011 deleterious(0.01) probably_damaging(0.987) 44 FFPE CTCTG A/T AATCA CMDL140200 FLD0011 FLD0035 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.017 89 QD no call 84 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL140200 FLD0011 FLD0035 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.998 1273 pass no call 19458 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140200 FLD0011 FLD0035 intron TP53 c.672+45G>A chr17 7578132 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578132", "IGV") low 0.001 2501 FS no call 13155 TP53_E00001255919_1 ENSG00000141510 6 of 10 23 FFPE GACAA C/T CACCC CMDL140200 FLD0011 FLD0035 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") medium 0.170 1013 pass no call 3480 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL140200 FLD0011 FLD0035 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.987 0.995 1991 2352 pass pass 69121 80881 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140200 FLD0011 FLD0035 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.986 0.989 1271 1267 pass pass 40252 40050 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140200 FLD0011 FLD0035 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.162 2949 no call QD 5078 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140202 FLD0012 FLD0036 intron EGFR c.2284-62C>T chr7 55248924 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248924", "IGV") low 0.002 1541 no call QD 115 EGFR_E00001601336_1 ENSG00000146648 19 of 27 4 FFPE GGGTC C/T ATGTG CMDL140202 FLD0012 FLD0036 intron EGFR c.2284-60T>C chr7 55248926 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55248926", "IGV") low 0.997 1541 no call QD 937 EGFR_E00001601336_1 18199332, 21869887 ENSG00000146648 19 of 27 rs10241451 C:0.1743 6 FFPE GTCCA T/C GTGCC CMDL140202 FLD0012 FLD0036 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.972 0.986 1919 1838 pass pass 78603 77533 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140202 FLD0012 FLD0036 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.994 0.993 1751 1653 pass pass 80166 74533 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140202 FLD0012 FLD0036 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.990 0.996 1918 1638 pass pass 80839 69666 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140202 FLD0012 FLD0036 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.142 1292 no call QD 1174 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL140202 FLD0012 FLD0036 nonsynonymous PIK3CA c.1645G>T p.D549Y Gat/Tat chr3 178936103 G T =hyperlink("http://localhost:60151/goto?locus=chr3:178936103", "IGV") medium 0.163 0.137 871 883 pass QD 2696 1756 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM219119, COSM17470 deleterious(0.01) possibly_damaging(0.724) 24 FFPE AGAAA G/T ATTTT CMDL140202 FLD0012 FLD0036 intron PTEN c.802-23C>A chr10 89720628 C A =hyperlink("http://localhost:60151/goto?locus=chr10:89720628", "IGV") low 0.143 0.159 111 96 QD pass 170 726 PTEN_E00001156315_1m ENSG00000171862 7 of 8 57 FFPE TTTTT C/A TTTTC CMDL140202 FLD0012 FLD0036 nonsynonymous PTEN c.1021T>G p.F341V Ttt/Gtt chr10 89720870 T G =hyperlink("http://localhost:60151/goto?locus=chr10:89720870", "IGV") high 0.193 0.181 2296 2272 pass pass 8782 7652 PTEN_E00001156315_7 ENSG00000171862 8 of 9 COSM5255 deleterious(0) possibly_damaging(0.862) 26 FFPE CAAAT T/G TTAAG CMDL140202 FLD0012 FLD0036 nonsynonymous PTEN c.389G>A p.R130Q cGa/cAa chr10 89692905 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692905", "IGV") low 0.201 0.201 3182 3055 QD QD 2786 3150 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CM991081, rs121909229, rs121913292, CM981670, COSM5817, COSM5033, COSM5277, COSM5216 deleterious(0.02) probably_damaging(0.989) likely_pathogenic,pathogenic,pathogenic 42 FFPE GGGAC G/A AACTG CMDL140202 FLD0012 FLD0036 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.003 1200 no call QD 46 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL140202 FLD0012 FLD0036 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.993 1200 no call QD 46 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140202 FLD0012 FLD0036 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.990 0.992 2791 2258 pass pass 86656 70637 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140202 FLD0012 FLD0036 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.993 0.990 1947 1874 pass pass 58108 57296 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140202 FLD0012 FLD0036 splice_acceptor TP53 c.1101-2A>C chr17 7573010 T G =hyperlink("http://localhost:60151/goto?locus=chr17:7573010", "IGV") low 0.368 1711 QD no call 2830 TP53_E00001757276_1 ENSG00000141510 10 of 10 rs587781664, CS111031, TP53_g.17908A>G, TP53_g.17908A>T, TP53_g.17908A>C, COSM1191161, COSM12663, COSM45409, COSM1386548, COSM1679487 1 FFPE GTGGC T/G GTAGG CMDL150010 FLD0013 FLD0037 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.511 0.395 1686 1705 pass pass 30830 22400 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150010 FLD0013 FLD0037 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.490 0.486 1676 1607 pass pass 28587 26872 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150010 FLD0013 FLD0037 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.537 0.453 1810 1775 pass pass 34847 26856 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150010 FLD0013 FLD0037 intron TP53 c.97-45G>A chr17 7579635 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579635", "IGV") medium 0.238 1065 pass no call 4152 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE TCAGC C/T CCCCA CMDL150010 FLD0013 FLD0037 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") medium 0.152 1065 pass no call 3006 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL150010 FLD0013 FLD0037 intron TP53 c.97-48G>A chr17 7579638 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579638", "IGV") low 0.097 0.092 1065 1247 QD LowQual,QD 1777 26 EXP0116_TP53_E3 ENSG00000141510 3 of 10 62 FFPE GCCCC C/T CAGCC CMDL150010 FLD0013 FLD0037 intron TP53 c.96+34G>A chr17 7579666 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579666", "IGV") low 0.107 1247 no call QD 372 EXP0116_TP53_E3 ENSG00000141510 3 of 10 69 FFPE CCCAG C/T CCTCC CMDL150010 FLD0013 FLD0037 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.018 113 no call QD 31 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150010 FLD0013 FLD0037 intron PTEN c.802-12T>C chr10 89720639 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720639", "IGV") low 0.014 101 QD no call 53 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs587781129 benign 46 FFPE TTTTT T/C TTTTT CMDL150010 FLD0013 FLD0037 intron PTEN c.802-9T>C chr10 89720642 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720642", "IGV") low 0.009 101 QD no call 145 PTEN_E00001156315_1m ENSG00000171862 7 of 8 43 FFPE TTTTT T/C TTTTT CMDL150010 FLD0013 FLD0037 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.005 1126 no call QD 269 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL150010 FLD0013 FLD0037 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.989 1126 no call QD 269 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150010 FLD0013 FLD0037 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.099 1219 no call QD 1035 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150010 FLD0013 FLD0037 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") low 0.111 0.116 1264 1220 QD QD 1914 2375 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL150010 FLD0013 FLD0037 intron TP53 c.74+49C>T chr17 7579790 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579790", "IGV") medium 0.165 1302 pass no call 4167 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs762400295 13 FFPE GGGCT G/A GGGTT CMDL150010 FLD0013 FLD0037 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.318 0.346 2530 2429 pass pass 15338 16869 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150010 FLD0013 FLD0037 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.544 0.531 844 784 pass pass 10338 9265 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150010 FLD0013 FLD0037 nonsynonymous TP53 c.742C>T p.R248W Cgg/Tgg chr17 7577539 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577539", "IGV") high 0.529 0.546 3300 3026 pass pass 34954 37294 TP53_E00001665758_1 ENSG00000141510 7 of 11 CM010465, CM900211, rs121912651, TP53_g.13379C>G, TP53_g.13379C>T, TP53_g.13379C>A, TP53_g.13379del, COSM11564, COSM45116, COSM10656, COSM44920, COSM120007, COSM1189381, COSM120005, COSM1189382, COSM3388183, COSM1640831, COSM120006, COSM1189383 deleterious(0) probably_damaging(1) pathogenic 73 FFPE CCTCC G/A GTTCA CMDL150010 FLD0013 FLD0037 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") low 0.113 3273 QD no call 58 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL150089 FLD0014 FLD0038 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.363 0.320 1775 1620 pass pass 19357 15430 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150089 FLD0014 FLD0038 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.337 0.341 4019 4000 pass pass 16153 18376 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150089 FLD0014 FLD0038 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.156 1063 QD no call 1866 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL150089 FLD0014 FLD0038 intron TP53 c.96+13G>A chr17 7579687 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579687", "IGV") medium 0.256 737 no call pass 2758 EXP0116_TP53_E3 ENSG00000141510 3 of 10 48 FFPE CCCAA C/T CCTTG CMDL150089 FLD0014 FLD0038 intron TP53 c.96+11G>A chr17 7579689 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579689", "IGV") low 0.097 1063 LowQual,QD no call 16 EXP0116_TP53_E3 ENSG00000141510 3 of 10 46 FFPE CAACC C/T TTGTC CMDL150089 FLD0014 FLD0038 nonsynonymous KRAS c.34G>T p.G12C Ggt/Tgt chr12 25398285 C A =hyperlink("http://localhost:60151/goto?locus=chr12:25398285", "IGV") high 0.325 0.312 4098 3849 pass pass 18718 16494 KRAS_AA_HS ENSG00000133703 2 of 6 CM076251, COSM518, COSM517, COSM516, COSM1152506, COSM1157797, COSM1140136 deleterious(0.04) probably_damaging(0.993) 25 FFPE GCCAC C/A AGCTC CMDL150089 FLD0014 FLD0038 nonsynonymous PIK3CA c.1637A>G p.Q546R cAg/cGg chr3 178936095 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178936095", "IGV") high 0.306 0.382 831 771 pass pass 7520 9558 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 rs397517201, COSM767, COSM25041, COSM12459, COSM446012, COSM1041496, COSM1757082 deleterious(0.02) probably_damaging(0.984) pathogenic 32 FFPE TGAGC A/G GGAGA CMDL150089 FLD0014 FLD0038 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.008 1068 no call QD 563 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL150089 FLD0014 FLD0038 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.988 1068 no call QD 563 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150089 FLD0014 FLD0038 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.995 0.994 2455 2305 pass pass 86420 83824 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150089 FLD0014 FLD0038 intron TP53 c.74+35C>T chr17 7579804 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579804", "IGV") low 0.118 2455 QD no call 1524 TP53_E00001596491_1 ENSG00000141510 2 of 10 27 FFPE GTGGG G/A GTGGT CMDL150089 FLD0014 FLD0038 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.996 0.990 1367 1259 pass pass 46730 39230 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150089 FLD0014 FLD0038 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.177 3228 QD no call 5511 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150089 FLD0014 FLD0038 splice_donor TP53 c.993+1G>C chr17 7576852 C G =hyperlink("http://localhost:60151/goto?locus=chr17:7576852", "IGV") low 0.162 4650 QD no call 1231 TP53_E00001789298_1 22291954 ENSG00000141510 9 of 10 rs11575997, CD002536, TP53_g.14066del, TP53_g.14066G>C, TP53_g.14066G>A, TP53_g.14066G>T, COSM44295, COSM119021, COSM6918, COSM323936, COSM165065, COSM119022, COSM4151771, COSM3717623, COSM4151770, COSM3717622 46 FFPE TAGTA C/G CTGAA CMDL150092 FLD0015 FLD0039 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.987 0.989 1923 1511 pass pass 82237 65308 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150092 FLD0015 FLD0039 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.995 0.990 1719 1411 pass pass 81482 66845 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150092 FLD0015 FLD0039 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.986 0.987 1878 1648 pass pass 78402 70011 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150092 FLD0015 FLD0039 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.671 0.619 4367 3344 pass pass 72266 49017 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150092 FLD0015 FLD0039 intron TP53 c.97-45G>A chr17 7579635 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579635", "IGV") low 0.107 1211 no call QD 2052 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE TCAGC C/T CCCCA CMDL150092 FLD0015 FLD0039 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.140 1316 QD no call 752 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL150092 FLD0015 FLD0039 intron TP53 c.96+16G>A chr17 7579684 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579684", "IGV") low 0.086 1211 no call QD 787 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs730882012 benign 51 FFPE CAGCC C/T AACCC CMDL150092 FLD0015 FLD0039 intron TP53 c.96+13G>A chr17 7579687 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579687", "IGV") medium 0.132 1211 no call pass 3678 EXP0116_TP53_E3 ENSG00000141510 3 of 10 48 FFPE CCCAA C/T CCTTG CMDL150092 FLD0015 FLD0039 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.987 1259 no call pass 51685 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150092 FLD0015 FLD0039 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.096 0.095 1405 1161 QD QD 803 988 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150092 FLD0015 FLD0039 intron TP53 c.74+53C>T chr17 7579786 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579786", "IGV") low 0.092 1164 no call QD 231 TP53_E00001596491_1 ENSG00000141510 2 of 10 9 FFPE TAGGG G/A GCTGG CMDL150092 FLD0015 FLD0039 intron TP53 c.74+42C>T chr17 7579797 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579797", "IGV") low 0.116 2819 QD no call 1081 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs767153311 20 FFPE GGTTG G/A GGTGG CMDL150092 FLD0015 FLD0039 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.996 0.995 2819 2349 pass pass 104654 86089 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150092 FLD0015 FLD0039 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.986 0.994 1479 1076 pass pass 49275 36619 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150092 FLD0015 FLD0039 3_prime_UTR TP53 c.*51C>T chr17 7572876 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572876", "IGV") low 0.070 1631 QD no call 99 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs760698953 7 FFPE GGGGA G/A GGAGA CMDL150092 FLD0015 FLD0039 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.221 3028 no call pass 7542 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150143 FLD0016 FLD0040 synonymous EGFR c.2406C>T c.2406C>T(p.%3D) gtC/gtT chr7 55249108 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249108", "IGV") low 0.181 2368 no call QD 2148 EGFR_E00001601336_2 ENSG00000146648 20 of 28 87 FFPE TATGT C/T CGGGA CMDL150143 FLD0016 FLD0040 nonsynonymous EGFR c.2453G>A p.C818Y tGt/tAt chr7 55249155 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249155", "IGV") low 0.110 1664 QD no call 1457 EGFR_E00001601336_2 ENSG00000146648 20 of 28 COSM23611 deleterious(0) probably_damaging(1) 40 FFPE CTGGT G/A TGTGC CMDL150143 FLD0016 FLD0040 nonsynonymous EGFR c.2455G>A p.V819M Gtg/Atg chr7 55249157 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249157", "IGV") low 0.108 1636 QD no call 2194 EGFR_E00001601336_2 ENSG00000146648 20 of 28 deleterious(0.02) probably_damaging(0.999) 38 FFPE GGTGT G/A TGCAG CMDL150143 FLD0016 FLD0040 synonymous EGFR c.2457G>A c.2457G>A(p.%3D) gtG/gtA chr7 55249159 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249159", "IGV") low 0.134 1635 QD no call 2942 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs56183713, COSM13400 likely_benign A:0.0002 36 FFPE TGTGT G/A CAGAT CMDL150143 FLD0016 FLD0040 splice_region,intron EGFR c.2626-6C>T chr7 55260453 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260453", "IGV") low 0.170 3516 no call QD 1870 EGFR_E00001631695_1 ENSG00000146648 21 of 27 66 FFPE ACCAT C/T CCAAG CMDL150143 FLD0016 FLD0040 nonsynonymous EGFR c.2630C>T p.P877L cCt/cTt chr7 55260463 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260463", "IGV") low 0.208 4302 QD no call 7233 EGFR_E00001631695_1 ENSG00000146648 22 of 28 deleterious(0) probably_damaging(1) 76 FFPE GGTGC C/T TATCA CMDL150143 FLD0016 FLD0040 synonymous EGFR c.2682G>A c.2682G>A(p.%3D) caG/caA chr7 55260515 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260515", "IGV") low 0.168 4287 QD no call 2023 EGFR_E00001631695_1 ENSG00000146648 22 of 28 rs749270913 38 FFPE CACCA G/A AGTGA CMDL150143 FLD0016 FLD0040 intron EGFR c.2701+16G>A chr7 55260550 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260550", "IGV") medium 0.137 1768 no call pass 3697 EGFR_E00001631695_1 ENSG00000146648 22 of 27 3 FFPE ATCCT G/A ATGCT CMDL150143 FLD0016 FLD0040 intron EGFR c.2470-33C>T chr7 55259379 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259379", "IGV") medium 0.222 1917 pass no call 11444 EGFR_E00001681524_1 ENSG00000146648 20 of 27 8 FFPE ATGAT C/T TGTCC CMDL150143 FLD0016 FLD0040 intron EGFR c.2470-31G>A chr7 55259381 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259381", "IGV") low 0.082 1422 no call QD 135 EGFR_E00001681524_1 ENSG00000146648 20 of 27 10 FFPE GATCT G/A TCCCT CMDL150143 FLD0016 FLD0040 intron EGFR c.2470-9C>T chr7 55259403 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259403", "IGV") low 0.188 3781 QD no call 5079 EGFR_E00001681524_1 ENSG00000146648 20 of 27 32 FFPE CTTCT C/T TGTTT CMDL150143 FLD0016 FLD0040 nonsynonymous EGFR c.2570G>A p.G857E gGg/gAg chr7 55259512 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259512", "IGV") low 0.099 1396 no call QD 1290 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM370916, COSM250050 deleterious(0) probably_damaging(1) 14 FFPE TTTTG G/A GCTGG CMDL150143 FLD0016 FLD0040 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.996 0.998 1824 1199 pass pass 78189 51449 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150143 FLD0016 FLD0040 nonsynonymous EGFR c.2729T>C p.F910S tTt/tCt chr7 55266437 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266437", "IGV") medium 0.371 3689 pass no call 23429 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(1) 54 FFPE GACCT T/C TGGAT CMDL150143 FLD0016 FLD0040 nonsynonymous EGFR c.2819C>T p.T940I aCc/aTc chr7 55266527 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266527", "IGV") low 0.154 3519 QD no call 1338 EGFR_E00001779947_2 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(1) 51 FFPE ATGTA C/T CATCG CMDL150143 FLD0016 FLD0040 intron EGFR c.2849-41C>T chr7 55267968 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55267968", "IGV") medium 0.173 1388 no call pass 5151 EGFR_E00001790701_1 ENSG00000146648 23 of 27 10 FFPE TCTTC C/T AGTGT CMDL150143 FLD0016 FLD0040 splice_region,intron EGFR c.2849-3C>T chr7 55268006 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268006", "IGV") low 0.163 2802 no call QD 1946 EGFR_E00001790701_1 ENSG00000146648 23 of 27 48 FFPE TTCCC C/T AGGCT CMDL150143 FLD0016 FLD0040 synonymous EGFR c.2883C>T c.2883C>T(p.%3D) ttC/ttT chr7 55268043 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268043", "IGV") low 0.145 2802 no call QD 1298 EGFR_E00001790701_1 ENSG00000146648 24 of 28 71 FFPE AAGTT C/T CGTGA CMDL150143 FLD0016 FLD0040 intron TP53 c.97-33G>A chr17 7579623 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579623", "IGV") low 0.177 314 no call QD 446 EXP0116_TP53_E3 ENSG00000141510 3 of 10 47 FFPE AGGAC C/T AGGTC CMDL150143 FLD0016 FLD0040 intron TP53 c.96+29G>A chr17 7579671 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579671", "IGV") low 0.298 95 pass no call 954 EXP0116_TP53_E3 ENSG00000141510 3 of 10 64 FFPE CCCTC C/T AGGTC CMDL150143 FLD0016 FLD0040 synonymous TP53 c.90C>T c.90C>T(p.%3D) aaC/aaT chr17 7579706 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579706", "IGV") low 0.274 95 pass no call 954 EXP0116_TP53_E3 ENSG00000141510 3 of 11 rs370992294, COSM1717722, COSM1717721, COSM1717724, COSM1717723, COSM1717725 29 FFPE AGAAC G/A TTGTT CMDL150143 FLD0016 FLD0040 intron PTEN c.802-161T>C chr10 89720490 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720490", "IGV") medium 0.146 1354 pass no call 4512 PTEN_E00001156315_1m ENSG00000171862 7 of 8 10 FFPE TAGTC T/C TTGTG CMDL150143 FLD0016 FLD0040 intron PTEN c.802-118T>C chr10 89720533 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720533", "IGV") medium 0.141 1104 no call pass 2742 PTEN_E00001156315_1m ENSG00000171862 7 of 8 53 FFPE TATTT T/C GTTGA CMDL150143 FLD0016 FLD0040 nonsynonymous PTEN c.958T>G p.L320V Tta/Gta chr10 89720807 T G =hyperlink("http://localhost:60151/goto?locus=chr10:89720807", "IGV") low 0.210 4544 QD no call 6763 PTEN_E00001156315_7 ENSG00000171862 8 of 9 COSM249832 deleterious(0.01) probably_damaging(0.942) 75 FFPE TTACT T/G TAACA CMDL150143 FLD0016 FLD0040 nonsynonymous PTEN c.1004G>A p.R335Q cGa/cAa chr10 89720853 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720853", "IGV") low 0.175 3804 no call QD 2417 PTEN_E00001156315_7 ENSG00000171862 8 of 9 CM004524, COSM1349620 deleterious(0.01) benign(0.084) 43 FFPE CAACC G/A ATACT CMDL150143 FLD0016 FLD0040 intron PTEN c.801+18A>G chr10 89717794 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717794", "IGV") medium 0.158 1738 pass no call 5353 PTEN_E00001156321_4m ENSG00000171862 7 of 8 rs777679092 25 FFPE CTTTC A/G TTGGG CMDL150143 FLD0016 FLD0040 intron PTEN c.801+42G>A chr10 89717818 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717818", "IGV") low 0.232 2748 no call QD 5440 PTEN_E00001156321_4m ENSG00000171862 7 of 8 49 FFPE ATAAG G/A ACAGA CMDL150143 FLD0016 FLD0040 intron PTEN c.801+73C>T chr10 89717849 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717849", "IGV") low 0.199 2748 no call QD 3357 PTEN_E00001156321_4m ENSG00000171862 7 of 8 80 FFPE TATGA C/T ATGTA CMDL150143 FLD0016 FLD0040 intron PTEN c.801+131C>T chr10 89717907 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717907", "IGV") low 0.116 1697 QD no call 2262 PTEN_E00001156321_4m ENSG00000171862 7 of 8 27 FFPE TCTGG C/T ATTGG CMDL150143 FLD0016 FLD0040 intron PTEN c.801+150G>A chr10 89717926 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717926", "IGV") low 0.125 1348 no call QD 2416 PTEN_E00001156321_4m ENSG00000171862 7 of 8 8 FFPE TATAA G/A GGTAA CMDL150143 FLD0016 FLD0040 nonsynonymous PTEN c.499A>C p.T167P Act/Cct chr10 89711881 A C =hyperlink("http://localhost:60151/goto?locus=chr10:89711881", "IGV") low 0.207 3158 no call QD 5662 PTEN_E00001156327_1 ENSG00000171862 6 of 9 CD075529, COSM5052, COSM5225 deleterious(0) probably_damaging(0.991) 37 FFPE GAGTA A/C CTATT CMDL150143 FLD0016 FLD0040 synonymous PTEN c.540C>T c.540C>T(p.%3D) taC/taT chr10 89711922 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711922", "IGV") low 0.115 1556 no call QD 1775 PTEN_E00001156327_4 ENSG00000171862 6 of 9 CM074469, HM971505, COSM36367 14 FFPE AGCTA C/T CTGTT CMDL150143 FLD0016 FLD0040 nonsynonymous PTEN c.623G>A p.G208D gGc/gAc chr10 89712005 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89712005", "IGV") low 0.089 3121 no call QD 570 PTEN_E00001156327_4 ENSG00000171862 6 of 9 deleterious(0.05) benign(0.049) 45 FFPE CAGTG G/A CGGAA CMDL150143 FLD0016 FLD0040 nonsynonymous PTEN c.625G>A p.G209R Gga/Aga chr10 89712007 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89712007", "IGV") low 0.094 3121 no call QD 735 PTEN_E00001156327_4 ENSG00000171862 6 of 9 rs765433422, COSM308351 deleterious(0.02) benign(0.149) 43 FFPE GTGGC G/A GAACT CMDL150143 FLD0016 FLD0040 nonsynonymous PTEN c.394G>A p.G132S Ggt/Agt chr10 89692910 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692910", "IGV") low 0.160 3226 QD no call 1101 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5032, COSM1561209 deleterious(0) probably_damaging(0.994) 47 FFPE GAACT G/A GTGTA CMDL150143 FLD0016 FLD0040 nonsynonymous PTEN c.425G>A p.R142Q cGg/cAg chr10 89692941 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692941", "IGV") low 0.191 2330 no call QD 3462 PTEN_E00001156330_3 ENSG00000171862 5 of 9 rs753630034, COSM30623, COSM5034, COSM1349539 tolerated(0.43) benign(0.111) 78 FFPE ACATC G/A GGGCA CMDL150143 FLD0016 FLD0040 synonymous PTEN c.438A>G c.438A>G(p.%3D) ttA/ttG chr10 89692954 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89692954", "IGV") low 0.171 3226 QD no call 1866 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM1349540 71 FFPE TTTTT A/G AAGGC CMDL150143 FLD0016 FLD0040 nonsynonymous PTEN c.443C>T p.A148V gCa/gTa chr10 89692959 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692959", "IGV") medium 0.224 2330 no call pass 5820 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM23660 deleterious(0.03) benign(0.394) 66 FFPE AAAGG C/T ACAAG CMDL150143 FLD0016 FLD0040 nonsynonymous PTEN c.466G>A p.G156R Ggg/Agg chr10 89692982 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692982", "IGV") medium 0.233 2330 no call pass 6168 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5103 deleterious(0.04) benign(0.236) 43 FFPE TCTAT G/A GGGAA CMDL150143 FLD0016 FLD0040 nonsynonymous PTEN c.484G>T p.D162Y Gac/Tac chr10 89693000 G T =hyperlink("http://localhost:60151/goto?locus=chr10:89693000", "IGV") high 0.158 0.172 1575 1135 pass pass 4204 4020 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5274 deleterious(0) probably_damaging(0.991) 25 FFPE CCAGA G/T ACAAA CMDL150143 FLD0016 FLD0040 nonsynonymous PTEN c.105G>A p.M35I atG/atA chr10 89653807 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89653807", "IGV") low 0.179 2880 no call QD 3886 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM1579758, COSM1505981 deleterious(0) possibly_damaging(0.889) 40 FFPE GCTAT G/A GGATT CMDL150143 FLD0016 FLD0040 nonsynonymous PTEN c.110T>C p.F37S tTt/tCt chr10 89653812 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89653812", "IGV") low 0.213 4027 QD no call 7833 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM5116 deleterious(0) probably_damaging(0.969) 45 FFPE GGGAT T/C TCCTG CMDL150143 FLD0016 FLD0040 nonsynonymous PTEN c.115G>A p.A39T Gca/Aca chr10 89653817 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89653817", "IGV") medium 0.397 2880 no call pass 19832 PTEN_E00001156351_1 ENSG00000171862 2 of 9 CM083057, COSM5073 deleterious(0) possibly_damaging(0.77) 50 FFPE TTCCT G/A CAGAA CMDL150143 FLD0016 FLD0040 synonymous PTEN c.132C>T c.132C>T(p.%3D) ggC/ggT chr10 89653834 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653834", "IGV") low 0.217 4027 QD no call 7929 PTEN_E00001156351_1 ENSG00000171862 2 of 9 rs150651961, COSM5168 benign,likely_benign T:0.0002 63 FFPE GAAGG C/T GTATA CMDL150143 FLD0016 FLD0040 synonymous PTEN c.141G>A c.141G>A(p.%3D) agG/agA chr10 89653843 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89653843", "IGV") low 0.179 2880 no call QD 3069 PTEN_E00001156351_1 ENSG00000171862 2 of 9 CD075530, COSM86072 54 FFPE TACAG G/A AACAA CMDL150143 FLD0016 FLD0040 nonsynonymous PTEN c.1091C>A p.S364Y tCt/tAt chr10 89725108 C A =hyperlink("http://localhost:60151/goto?locus=chr10:89725108", "IGV") high 0.164 0.163 2370 1853 pass pass 8194 6070 PTEN_E00001456541_2 ENSG00000171862 9 of 9 COSM23645 tolerated(0.13) possibly_damaging(0.736) 20 FFPE AACTT C/A TGTAA CMDL150143 FLD0016 FLD0040 intron TP53 c.74+40C>T chr17 7579799 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579799", "IGV") medium 0.502 2012 pass no call 19143 TP53_E00001596491_1 ENSG00000141510 2 of 10 22 FFPE TTGGG G/A TGGGG CMDL150143 FLD0016 FLD0040 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.992 0.983 2012 531 pass pass 77886 15849 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150143 FLD0016 FLD0040 nonsynonymous TP53 c.275C>T p.P92L cCc/cTc chr17 7579412 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579412", "IGV") low 0.148 181 no call QD 114 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11506C>T, COSM45972 deleterious(0.03) possibly_damaging(0.625) 35 FFPE ACAGG G/A GCCAG CMDL150143 FLD0016 FLD0040 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.997 0.985 351 181 pass pass 12997 6602 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150143 FLD0016 FLD0040 intron TP53 c.782+21C>T chr17 7577478 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577478", "IGV") low 0.108 989 no call QD 1290 TP53_E00001665758_1 ENSG00000141510 7 of 10 rs201930255 C:0.0002 29 FFPE GTGCA G/A GGTGG CMDL150143 FLD0016 FLD0040 intron TP53 c.1100+26C>T chr17 7573901 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573901", "IGV") low 0.107 1070 no call QD 333 TP53_E00001728015_1 ENSG00000141510 10 of 10 rs780532950 21 FFPE GTAGG G/A CCAGG CMDL150143 FLD0016 FLD0040 synonymous TP53 c.1041C>T c.1041C>T(p.%3D) gcC/gcT chr17 7573986 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573986", "IGV") low 0.206 2477 QD no call 4265 TP53_E00001728015_1 ENSG00000141510 10 of 11 COSM96587 51 FFPE TCCAA G/A GCCTC CMDL150143 FLD0016 FLD0040 synonymous TP53 c.1014C>T c.1014C>T(p.%3D) ttC/ttT chr17 7574013 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7574013", "IGV") low 0.094 1220 QD no call 837 TP53_E00001728015_1 ENSG00000141510 10 of 11 rs150293825, TP53_g.16905C>T, COSM45126, COSM235693 C:0.0002 24 FFPE ATCTC G/A AAGCG CMDL150143 FLD0016 FLD0040 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.550 2611 no call pass 34110 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150143 FLD0016 FLD0040 3_prime_UTR TP53 c.*34C>T chr17 7572893 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572893", "IGV") low 0.160 2640 QD no call 4007 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs545818827 A:0.0002 24 FFPE GGTGG G/A AGGCT CMDL150143 FLD0016 FLD0040 3_prime_UTR TP53 c.*19C>T chr17 7572908 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572908", "IGV") medium 0.240 0.213 2640 2611 pass QD 10337 4968 TP53_E00001757276_1 ENSG00000141510 11 of 11 39 FFPE GTGGG G/A AACAA CMDL150143 FLD0016 FLD0040 synonymous TP53 c.1137C>T c.1137C>T(p.%3D) cgC/cgT chr17 7572972 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572972", "IGV") medium 0.519 2611 no call pass 28545 TP53_E00001757276_1 ENSG00000141510 11 of 11 COSM1386542, COSM1386543 39 FFPE TTATG G/A CGGGA CMDL150143 FLD0016 FLD0040 nonsynonymous TP53 c.935C>T p.T312I aCc/aTc chr17 7576911 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576911", "IGV") low 0.073 4928 QD no call 596 TP53_E00001789298_1 ENSG00000141510 9 of 11 rs145151284, TP53_g.14007C>T, TP53_g.14007del, TP53_g.14007C>G, COSM44967, COSM46108 deleterious(0.01) possibly_damaging(0.553) uncertain_significance C:0.0002 53 FFPE AGCTG G/A TGTTG CMDL150155 FLD0017 FLD0041 intron EGFR c.2284-34G>A chr7 55248952 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55248952", "IGV") low 0.101 932 QD no call 1071 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs202058122 32 FFPE CATGC G/A AAGCC CMDL150155 FLD0017 FLD0041 intron EGFR c.2284-25C>T chr7 55248961 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248961", "IGV") medium 0.201 954 no call pass 4464 EGFR_E00001601336_1 ENSG00000146648 19 of 27 41 FFPE CCACA C/T TGACG CMDL150155 FLD0017 FLD0041 nonsynonymous EGFR c.2308G>A p.D770N Gac/Aac chr7 55249010 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249010", "IGV") low 0.193 2383 QD no call 3442 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM14068 tolerated(0.14) benign(0.042) 83 FFPE GCGTG G/A ACAAC CMDL150155 FLD0017 FLD0041 nonsynonymous EGFR c.2354C>T p.T785I aCc/aTc chr7 55249056 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249056", "IGV") medium 0.228 1451 pass no call 7797 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM53288, COSM28930 deleterious(0) probably_damaging(1) 37 FFPE CTCCA C/T CGTGC CMDL150155 FLD0017 FLD0041 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.983 0.980 1451 1387 pass pass 61735 57634 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150155 FLD0017 FLD0041 nonsynonymous EGFR c.2380C>T p.P794S Ccc/Tcc chr7 55249082 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249082", "IGV") low 0.082 1386 no call QD 61 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs370289230 deleterious(0.03) probably_damaging(1) 11 FFPE TCATG C/T CCTTC CMDL150155 FLD0017 FLD0041 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.995 0.993 1545 1531 pass pass 74462 75249 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150155 FLD0017 FLD0041 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.988 0.970 1596 1640 pass pass 67752 67278 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150155 FLD0017 FLD0041 intron TP53 c.97-45G>A chr17 7579635 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579635", "IGV") medium 0.129 1289 pass no call 4668 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE TCAGC C/T CCCCA CMDL150155 FLD0017 FLD0041 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") medium 0.505 1281 no call pass 17852 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL150155 FLD0017 FLD0041 intron TP53 c.96+24G>A chr17 7579676 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579676", "IGV") medium 0.223 1289 pass no call 4677 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE CAGGT C/T CCCAG CMDL150155 FLD0017 FLD0041 intron TP53 c.96+22G>A chr17 7579678 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579678", "IGV") low 0.275 1281 no call QD 2438 EXP0116_TP53_E3 ENSG00000141510 3 of 10 57 FFPE GGTCC C/T CAGCC CMDL150155 FLD0017 FLD0041 intron TP53 c.96+21G>A chr17 7579679 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579679", "IGV") low 0.221 1289 QD no call 1175 EXP0116_TP53_E3 ENSG00000141510 3 of 10 56 FFPE GTCCC C/T AGCCC CMDL150155 FLD0017 FLD0041 nonsynonymous PIK3CA c.3140A>G p.H1047R cAt/cGt chr3 178952085 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178952085", "IGV") high 0.378 0.411 3000 3142 pass pass 18183 22688 PIK3CA_Exn21_gap 25710561 ENSG00000121879 21 of 21 rs121913279, COSM776, COSM775, COSM249874, COSM94987, COSM94986 tolerated(0.11) possibly_damaging(0.529) pathogenic 28 FFPE TGCAC A/G TCATG CMDL150155 FLD0017 FLD0041 intron PTEN c.802-34C>T chr10 89720617 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720617", "IGV") low 0.182 92 pass no call 217 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs531071483 68 FFPE CATTT C/T ATTTC CMDL150155 FLD0017 FLD0041 splice_region,intron PTEN c.802-7T>A chr10 89720644 T A =hyperlink("http://localhost:60151/goto?locus=chr10:89720644", "IGV") medium 0.014 101 no call pass 246 PTEN_E00001156315_1m ENSG00000171862 7 of 8 41 FFPE TTTTT T/A TTTTA CMDL150155 FLD0017 FLD0041 nonsynonymous TP53 c.659A>G p.Y220C tAt/tGt chr17 7578190 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578190", "IGV") high 0.892 0.922 1963 1875 pass pass 52898 55787 TP53_E00001255919_1 25404506 ENSG00000141510 6 of 11 CM015378, CM951227, rs121912666, TP53_g.12728A>T, TP53_g.12728A>C, TP53_g.12728A>G, COSM10758, COSM43850, COSM1564197, COSM99720, COSM251427, COSM1564198, COSM251426, COSM99718, COSM1564199, COSM3355993, COSM3675523, COSM1644277, COSM3675522, COSM99719, COSM251428, COSM1564200 deleterious(0) probably_damaging(1) pathogenic 63 FFPE GCTCA T/C AGGGC CMDL150155 FLD0017 FLD0041 intron TP53 c.74+56C>T chr17 7579783 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579783", "IGV") low 0.082 1159 QD no call 759 TP53_E00001596491_1 ENSG00000141510 2 of 10 6 FFPE TGCTA G/A GGGGC CMDL150155 FLD0017 FLD0041 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") medium 0.167 1159 pass no call 4985 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150155 FLD0017 FLD0041 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") low 0.117 1160 QD no call 2155 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL150155 FLD0017 FLD0041 intron TP53 c.74+48C>T chr17 7579791 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579791", "IGV") medium 0.210 1808 no call pass 7412 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs765863585 14 FFPE GGCTG G/A GGTTG CMDL150155 FLD0017 FLD0041 intron TP53 c.74+46C>T chr17 7579793 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579793", "IGV") low 0.124 1815 no call QD 344 TP53_E00001596491_1 ENSG00000141510 2 of 10 16 FFPE CTGGG G/A TTGGG CMDL150155 FLD0017 FLD0041 intron TP53 c.74+41C>T chr17 7579798 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579798", "IGV") medium 0.220 1815 no call pass 7770 TP53_E00001596491_1 ENSG00000141510 2 of 10 21 FFPE GTTGG G/A GTGGG CMDL150155 FLD0017 FLD0041 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") medium 0.162 2302 pass no call 8680 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150155 FLD0017 FLD0041 intron TP53 c.74+36C>T chr17 7579803 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579803", "IGV") medium 0.172 2302 pass no call 8072 TP53_E00001596491_1 ENSG00000141510 2 of 10 26 FFPE GGTGG G/A GGTGG CMDL150155 FLD0017 FLD0041 intron TP53 c.74+32C>T chr17 7579807 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579807", "IGV") medium 0.147 2302 pass no call 5968 TP53_E00001596491_1 ENSG00000141510 2 of 10 30 FFPE GGGGT G/A GTGGG CMDL150155 FLD0017 FLD0041 intron TP53 c.74+31C>T chr17 7579808 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579808", "IGV") medium 0.251 2302 pass no call 11905 TP53_E00001596491_1 ENSG00000141510 2 of 10 31 FFPE GGGTG G/A TGGGC CMDL150155 FLD0017 FLD0041 synonymous TP53 c.264C>T c.264C>T(p.%3D) gcC/gcT chr17 7579423 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579423", "IGV") low 0.142 0.124 345 322 QD QD 560 328 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11495C>T 46 FFPE GAGGG G/A GCTGG CMDL150155 FLD0017 FLD0041 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.269 0.186 345 322 pass pass 1332 893 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150155 FLD0017 FLD0041 3_prime_UTR TP53 c.*51C>T chr17 7572876 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572876", "IGV") low 0.080 1382 QD no call 50 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs760698953 7 FFPE GGGGA G/A GGAGA CMDL150155 FLD0017 FLD0041 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.132 2527 QD no call 1561 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150155 FLD0017 FLD0041 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.169 2527 pass no call 5118 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150155 FLD0017 FLD0041 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") low 0.140 2527 QD no call 2434 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL150155 FLD0017 FLD0041 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") low 0.166 3115 no call QD 3953 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL150173 FLD0018 FLD0042 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.542 0.653 1197 1791 pass pass 23355 44062 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150173 FLD0018 FLD0042 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.671 0.658 1234 1527 pass pass 35013 41612 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150173 FLD0018 FLD0042 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.586 0.619 1454 1590 pass pass 31992 36599 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150173 FLD0018 FLD0042 intron TP53 c.97-45G>A chr17 7579635 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579635", "IGV") low 0.245 1020 no call QD 564 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE TCAGC C/T CCCCA CMDL150173 FLD0018 FLD0042 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.015 88 LowQual,QD no call 11 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150173 FLD0018 FLD0042 synonymous TP53 c.639A>G c.639A>G(p.%3D) cgA/cgG chr17 7578210 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578210", "IGV") high 0.824 0.800 2150 2627 pass pass 49929 56715 TP53_E00001255919_1 20455025, 18798306, 15450681, 23543587, 24218030, 22829934, 18594532, 21869887, 17133269 ENSG00000141510 6 of 11 CX984230, rs1800372, TP53_g.12708A>T, COSM249885, COSM1741221, COSM1741223, COSM1741225, COSM3755916, COSM1741222, COSM1741224 benign C:0.0054 43 FFPE CTATG T/C CGAAA CMDL150173 FLD0018 FLD0042 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.089 1133 no call QD 291 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150173 FLD0018 FLD0042 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.863 0.766 1823 2271 pass pass 51166 52272 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150173 FLD0018 FLD0042 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") low 0.113 1823 QD no call 628 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL150173 FLD0018 FLD0042 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.949 0.934 1240 1292 pass pass 38812 39088 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150173 FLD0018 FLD0042 nonsynonymous TP53 c.711G>A p.M237I atG/atA chr17 7577570 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577570", "IGV") high 0.599 0.634 2436 3180 pass pass 33065 48478 TP53_E00001665758_1 ENSG00000141510 7 of 11 rs587782664, CM011014, TP53_g.13348G>C, TP53_g.13348G>T, TP53_g.13348G>A, TP53_g.13348del, COSM10834, COSM44415, COSM11063, COSM99648, COSM301403, COSM1189384, COSM99646, COSM301402, COSM1189385, COSM3378348, COSM3378444, COSM1640834, COSM1640835, COSM301404, COSM99647, COSM1189386 deleterious(0) probably_damaging(0.997) likely_pathogenic 42 FFPE TTACA C/T ATGTA CMDL150173 FLD0018 FLD0042 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.138 2466 QD no call 898 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150178 FLD0019 FLD0043 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.979 0.983 1490 1731 pass pass 61984 73294 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150178 FLD0019 FLD0043 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.998 0.992 1401 1548 pass pass 65761 71321 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150178 FLD0019 FLD0043 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.994 0.993 1541 1598 pass pass 65410 67852 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150178 FLD0019 FLD0043 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.754 0.777 3312 3622 pass pass 66960 75614 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150178 FLD0019 FLD0043 synonymous PTEN c.132C>T c.132C>T(p.%3D) ggC/ggT chr10 89653834 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653834", "IGV") high 0.847 0.860 3212 3419 pass pass 75232 86465 PTEN_E00001156351_1 ENSG00000171862 2 of 9 rs150651961, COSM5168 benign,likely_benign T:0.0002 63 FFPE GAAGG C/T GTATA CMDL150178 FLD0019 FLD0043 nonsynonymous TP53 c.659A>G p.Y220C tAt/tGt chr17 7578190 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578190", "IGV") high 0.711 0.709 2015 2002 pass pass 35401 34704 TP53_E00001255919_1 25404506 ENSG00000141510 6 of 11 CM015378, CM951227, rs121912666, TP53_g.12728A>T, TP53_g.12728A>C, TP53_g.12728A>G, COSM10758, COSM43850, COSM1564197, COSM99720, COSM251427, COSM1564198, COSM251426, COSM99718, COSM1564199, COSM3355993, COSM3675523, COSM1644277, COSM3675522, COSM99719, COSM251428, COSM1564200 deleterious(0) probably_damaging(1) pathogenic 63 FFPE GCTCA T/C AGGGC CMDL150178 FLD0019 FLD0043 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.865 0.925 2113 2275 pass pass 52690 68077 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150178 FLD0019 FLD0043 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.949 0.974 1568 1620 pass pass 46732 49975 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150211 FLD0020 FLD0044 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.492 0.483 1613 1697 pass pass 27906 25397 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150211 FLD0020 FLD0044 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.505 0.492 1509 1568 pass pass 27370 26718 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150211 FLD0020 FLD0044 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.995 0.993 1630 1554 pass pass 69128 65808 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150211 FLD0020 FLD0044 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.485 0.507 3488 3612 pass pass 30802 36762 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150211 FLD0020 FLD0044 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") low 0.214 0.168 1102 1348 QD QD 1842 948 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL150211 FLD0020 FLD0044 intron PTEN c.802-11T>C chr10 89720640 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720640", "IGV") low 0.010 104 no call QD 50 PTEN_E00001156315_1m ENSG00000171862 7 of 8 45 FFPE TTTTT T/C TTTTT CMDL150211 FLD0020 FLD0044 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.800 0.820 2304 2237 pass pass 46372 49800 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150211 FLD0020 FLD0044 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.933 0.935 1468 1769 pass pass 40116 48298 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150215 FLD0021 FLD0045 splice_region,intron EGFR c.2284-7C>T chr7 55248979 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248979", "IGV") low 0.126 2800 QD no call 4301 EGFR_E00001601336_1 ENSG00000146648 19 of 27 59 FFPE CCCTC C/T CTCCA CMDL150215 FLD0021 FLD0045 synonymous EGFR c.2289C>T c.2289C>T(p.%3D) gcC/gcT chr7 55248991 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248991", "IGV") low 0.128 2800 QD no call 4451 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs117420095 likely_benign G:0.0006 71 FFPE GAAGC C/T TACGT CMDL150215 FLD0021 FLD0045 synonymous EGFR c.2310C>T c.2310C>T(p.%3D) gaC/gaT chr7 55249012 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249012", "IGV") medium 0.500 2706 no call pass 25541 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs397517110 likely_benign 81 FFPE GTGGA C/T AACCC CMDL150215 FLD0021 FLD0045 nonsynonymous EGFR c.2620G>A p.G874S Ggc/Agc chr7 55259562 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259562", "IGV") low 0.080 930 no call QD 83 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM26438 deleterious(0.01) probably_damaging(0.986) 10 FFPE AAGGA G/A GCAAA CMDL150215 FLD0021 FLD0045 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.998 0.996 1592 1552 pass pass 68741 66558 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150215 FLD0021 FLD0045 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.551 0.477 3649 3711 pass pass 42860 34057 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150215 FLD0021 FLD0045 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") high 0.759 0.851 904 814 pass pass 20467 16948 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL150215 FLD0021 FLD0045 intron TP53 c.97-39G>A chr17 7579629 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579629", "IGV") medium 0.303 904 pass no call 3546 EXP0116_TP53_E3 ENSG00000141510 3 of 10 53 FFPE AGGTC C/T TCAGC CMDL150215 FLD0021 FLD0045 intron TP53 c.97-45G>A chr17 7579635 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579635", "IGV") medium 0.177 904 pass no call 2362 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE TCAGC C/T CCCCA CMDL150215 FLD0021 FLD0045 nonsynonymous PIK3CA c.1637A>G p.Q546R cAg/cGg chr3 178936095 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178936095", "IGV") high 0.542 0.496 793 864 pass pass 15842 15321 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 rs397517201, COSM767, COSM25041, COSM12459, COSM446012, COSM1041496, COSM1757082 deleterious(0.02) probably_damaging(0.984) pathogenic 32 FFPE TGAGC A/G GGAGA CMDL150215 FLD0021 FLD0045 splice_region,intron PTEN c.802-7T>C chr10 89720644 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720644", "IGV") medium 0.017 139 pass no call 330 PTEN_E00001156315_1m ENSG00000171862 7 of 8 41 FFPE TTTTT T/C TTTTA CMDL150215 FLD0021 FLD0045 nonsynonymous,splice_region PTEN c.493G>A p.G165R Gga/Aga chr10 89711875 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89711875", "IGV") high 0.475 0.469 3399 3504 pass pass 32419 31144 PTEN_E00001156327_1 ENSG00000171862 6 of 9 rs587782603, CM109590, CM110122, COSM5091, COSM36365 deleterious(0) probably_damaging(0.996) pathogenic 43 FFPE ACCAG G/A GAGTA CMDL150215 FLD0021 FLD0045 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.997 1095 QD no call 126 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150215 FLD0021 FLD0045 intron TP53 c.672+62A>C chr17 7578115 T G =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.002 966 no call QD 60 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/G GGAGG CMDL150215 FLD0021 FLD0045 intron TP53 c.672+61C>T chr17 7578116 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578116", "IGV") low 0.002 1095 QD no call 126 TP53_E00001255919_1 ENSG00000141510 6 of 10 rs576587852 A:0.0002 7 FFPE CACCT G/A GAGGG CMDL150215 FLD0021 FLD0045 intron TP53 c.74+53C>T chr17 7579786 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579786", "IGV") medium 0.271 774 no call pass 5679 TP53_E00001596491_1 ENSG00000141510 2 of 10 9 FFPE TAGGG G/A GCTGG CMDL150215 FLD0021 FLD0045 intron TP53 c.74+43C>T chr17 7579796 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579796", "IGV") low 0.170 1690 QD no call 1852 TP53_E00001596491_1 ENSG00000141510 2 of 10 19 FFPE GGGTT G/A GGGTG CMDL150215 FLD0021 FLD0045 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.500 0.569 1690 1545 pass pass 19516 21770 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150215 FLD0021 FLD0045 intron TP53 c.74+29C>T chr17 7579810 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579810", "IGV") low 0.117 1690 QD no call 298 TP53_E00001596491_1 ENSG00000141510 2 of 10 33 FFPE GTGGT G/A GGCCT CMDL150215 FLD0021 FLD0045 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.860 0.807 668 621 pass pass 15811 13537 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150215 FLD0021 FLD0045 3_prime_UTR TP53 c.*51C>T chr17 7572876 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572876", "IGV") medium 0.134 1386 pass no call 4135 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs760698953 7 FFPE GGGGA G/A GGAGA CMDL150215 FLD0021 FLD0045 3_prime_UTR TP53 c.*47C>T chr17 7572880 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572880", "IGV") low 0.104 1361 no call QD 1523 TP53_E00001757276_1 ENSG00000141510 11 of 11 11 FFPE AGGGA G/A AGATG CMDL150215 FLD0021 FLD0045 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") low 0.133 2919 QD no call 2069 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL150215 FLD0021 FLD0045 3_prime_UTR TP53 c.*34C>T chr17 7572893 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572893", "IGV") low 0.140 2919 QD no call 2700 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs545818827 A:0.0002 24 FFPE GGTGG G/A AGGCT CMDL150220 FLD0022 FLD0046 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.466 0.449 1389 1369 pass pass 22442 21591 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150220 FLD0022 FLD0046 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.510 0.505 1380 1387 pass pass 24719 25110 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150220 FLD0022 FLD0046 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.990 0.987 1388 1388 pass pass 58506 58496 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150220 FLD0022 FLD0046 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") high 0.520 0.379 1067 1027 pass pass 12519 8283 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL150220 FLD0022 FLD0046 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") medium 0.188 1027 no call pass 5216 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL150220 FLD0022 FLD0046 intron TP53 c.96+53G>A chr17 7579647 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579647", "IGV") medium 0.000 1067 pass no call 2202 EXP0116_TP53_E3 ENSG00000141510 3 of 10 71 FFPE CCCCC C/T AGCCC CMDL150220 FLD0022 FLD0046 nonsynonymous KRAS c.35G>A p.G12D gGt/gAt chr12 25398284 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") high 0.332 0.331 3317 3296 pass pass 15812 14962 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) benign(0.361) 26 FFPE CGCCA C/T CAGCT CMDL150220 FLD0022 FLD0046 intron PTEN c.802-14T>C chr10 89720637 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720637", "IGV") high 0.113 0.088 235 217 pass pass 883 668 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs775342006 48 FFPE TCTTT T/C TTTTT CMDL150220 FLD0022 FLD0046 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") high 0.061 0.056 235 217 pass pass 779 518 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150220 FLD0022 FLD0046 5_prime_UTR PTEN c.-9C>G chr10 89624218 C G =hyperlink("http://localhost:60151/goto?locus=chr10:89624218", "IGV") high 0.476 0.418 1229 1210 pass pass 20032 16698 PTEN_E00001456562_1 24632578 ENSG00000171862 1 of 9 CR033149, rs11202592, COSM5915, COSM23647 benign G:0.0110 24 FFPE ACAGG C/G TCCCA CMDL150220 FLD0022 FLD0046 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.668 0.493 1928 2045 pass pass 34954 24979 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150220 FLD0022 FLD0046 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.854 0.815 904 851 pass pass 22886 18528 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150227 FLD0023 FLD0047 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.985 0.989 1838 1687 pass pass 76599 70962 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150227 FLD0023 FLD0047 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.990 0.993 1709 1406 pass pass 77723 65054 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150227 FLD0023 FLD0047 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.993 0.997 1787 1507 pass pass 75628 64243 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150227 FLD0023 FLD0047 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.503 0.473 4202 3475 pass pass 41802 31952 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150227 FLD0023 FLD0047 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") low 0.084 952 no call QD 254 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL150227 FLD0023 FLD0047 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.147 1253 QD no call 1073 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL150227 FLD0023 FLD0047 nonsynonymous PTEN c.376G>T p.A126S Gct/Tct chr10 89692892 G T =hyperlink("http://localhost:60151/goto?locus=chr10:89692892", "IGV") high 0.783 0.776 1842 1590 pass pass 55295 47126 PTEN_E00001156330_1 ENSG00000171862 5 of 9 CM110132, COSM5211, COSM28889, COSM5051 deleterious(0) probably_damaging(0.987) 7 FFPE GTAAA G/T CTGGA CMDL150227 FLD0023 FLD0047 nonsynonymous PTEN c.376G>T p.A126S Gct/Tct chr10 89692892 G T =hyperlink("http://localhost:60151/goto?locus=chr10:89692892", "IGV") high 0.422 0.466 1572 1305 pass pass 23301 21229 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CM110132, COSM5211, COSM28889, COSM5051 deleterious(0) probably_damaging(0.987) 29 FFPE GTAAA G/T CTGGA CMDL150227 FLD0023 FLD0047 nonsynonymous PTEN c.388C>G p.R130G Cga/Gga chr10 89692904 C G =hyperlink("http://localhost:60151/goto?locus=chr10:89692904", "IGV") high 0.480 0.463 3191 2652 pass pass 33156 24011 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CM971273, CM094223, rs121909224, COSM5329, COSM5219, COSM5152, COSM308347 deleterious(0) probably_damaging(0.999) pathogenic 41 FFPE AGGGA C/G GAACT CMDL150227 FLD0023 FLD0047 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.005 1023 no call QD 231 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL150227 FLD0023 FLD0047 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.993 1025 no call QD 231 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150227 FLD0023 FLD0047 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.991 0.990 2547 1987 pass pass 85459 69557 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150227 FLD0023 FLD0047 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.997 0.992 1821 1361 pass pass 57690 46007 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA NTC_012_L2 FLD0024 FLD0048 intron EGFR c.2284-60T>C chr7 55248926 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55248926", "IGV") low 0.333 6 pass no call 37 EGFR_E00001601336_1 18199332, 21869887 ENSG00000146648 19 of 27 rs10241451 C:0.1743 6 Blank GTCCA T/C GTGCC NTC_012_L2 FLD0024 FLD0048 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") low 0.833 6 pass no call 163 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 Blank GTGCA G/A CTCAT NTC_012_L2 FLD0024 FLD0048 nonsynonymous EGFR c.2420A>G p.D807G gAc/gGc chr7 55249122 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55249122", "IGV") low 1.000 2 no call LowQual 22 EGFR_E00001601336_2 ENSG00000146648 20 of 28 tolerated(0.23) possibly_damaging(0.455) 73 Blank CAAAG A/G CAATA NTC_012_L2 FLD0024 FLD0048 nonsynonymous EGFR c.2636A>G p.K879R aAg/aGg chr7 55260469 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55260469", "IGV") low 1.000 2 LowQual no call 22 EGFR_E00001631695_1 ENSG00000146648 22 of 28 deleterious(0) probably_damaging(1) 82 Blank TATCA A/G GTGGA NTC_012_L2 FLD0024 FLD0048 synonymous EGFR c.2508C>T c.2508C>T(p.%3D) cgC/cgT chr7 55259450 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259450", "IGV") low 0.222 18 LowQual,QD no call 17 EGFR_E00001681524_2 17956637, 21264207, 23093229, 22192147, 23211371, 21869887, 16324836 ENSG00000146648 21 of 28 rs2229066, COSM85893 benign T:0.0054 34 Blank CACCG C/T GACCT NTC_012_L2 FLD0024 FLD0048 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") low 1.000 3 no call pass 96 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 Blank GTGAC T/C GTTTG NTC_012_L2 FLD0024 FLD0048 nonsynonymous EGFR c.3025G>A p.D1009N Gac/Aac chr7 55268959 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268959", "IGV") low 0.500 4 no call pass 50 EGFR_E00001801208_2 ENSG00000146648 25 of 28 rs148019583, COSM3639757 deleterious(0.03) possibly_damaging(0.813) 21 Blank TGGAC G/A ACGTG NTC_012_L2 FLD0024 FLD0048 synonymous EGFR c.3030G>A c.3030G>A(p.%3D) gtG/gtA chr7 55268964 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268964", "IGV") low 0.500 4 no call pass 50 EGFR_E00001801208_2 ENSG00000146648 25 of 28 26 Blank GACGT G/A GTGGA NTC_012_L2 FLD0024 FLD0048 intron EGFR c.3114+16C>T chr7 55269064 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269064", "IGV") low 0.500 4 no call LowQual 30 EGFR_E00001801208_2 ENSG00000146648 25 of 27 15 Blank TCTGT C/T TCTCT NTC_012_L2 FLD0024 FLD0048 intron EGFR c.3114+25T>C chr7 55269073 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55269073", "IGV") low 0.500 2 no call LowQual 11 EGFR_E00001801208_2 ENSG00000146648 25 of 27 6 Blank CTCTC T/C CTCTC NTC_012_L2 FLD0024 FLD0048 nonsynonymous KRAS c.32C>T p.A11V gCt/gTt chr12 25398287 G A =hyperlink("http://localhost:60151/goto?locus=chr12:25398287", "IGV") low 1.000 2 LowQual no call 22 KRAS_AA_HS ENSG00000133703 2 of 6 COSM511 deleterious(0.03) possibly_damaging(0.807) 23 Blank CACCA G/A CTCCA NTC_012_L2 FLD0024 FLD0048 nonsynonymous PTEN c.776A>G p.H259R cAc/cGc chr10 89717751 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717751", "IGV") low 0.333 6 no call pass 44 PTEN_E00001156321_2 ENSG00000171862 7 of 9 deleterious(0.03) benign(0.063) 25 Blank CTTCC A/G CAAAC NTC_012_L2 FLD0024 FLD0048 nonsynonymous PTEN c.785A>G p.N262S aAc/aGc chr10 89717760 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717760", "IGV") low 0.333 6 no call pass 44 PTEN_E00001156321_2 ENSG00000171862 7 of 9 rs763784377 tolerated(0.21) benign(0.009) 16 Blank ACAGA A/G CAAGA NTC_012_L2 FLD0024 FLD0048 intron PTEN c.801+117T>C chr10 89717893 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89717893", "IGV") low 0.250 7 LowQual no call 21 PTEN_E00001156321_4m ENSG00000171862 7 of 8 41 Blank GGTGT T/C TTGCT NTC_012_L2 FLD0024 FLD0048 intron PTEN c.493-47G>A chr10 89711828 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89711828", "IGV") low 0.500 4 no call pass 50 PTEN_E00001156327_1 ENSG00000171862 5 of 8 33 Blank ATAAT G/A GAACA NTC_012_L2 FLD0024 FLD0048 intron PTEN c.493-44A>G chr10 89711831 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89711831", "IGV") low 0.500 4 no call pass 50 PTEN_E00001156327_1 ENSG00000171862 5 of 8 rs761470435 36 Blank ATGGA A/G CATTT NTC_012_L2 FLD0024 FLD0048 synonymous PTEN c.465T>C c.465T>C(p.%3D) taT/taC chr10 89692981 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89692981", "IGV") low 1.000 2 no call LowQual 22 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM1349548 44 Blank TTCTA T/C GGGGA NTC_012_L2 FLD0024 FLD0048 intron PTEN c.165-24T>C chr10 89685246 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89685246", "IGV") low 0.400 2 LowQual no call 22 PTEN_E00001156344_1 ENSG00000171862 2 of 8 47 Blank GGCTT T/C TTGTT NTC_012_L2 FLD0024 FLD0048 intron TP53 c.993+170C>T chr17 7576683 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576683", "IGV") low 0.500 3 LowQual no call 12 TP53_00001404886_13 ENSG00000141510 9 of 10 32 Blank TATAA G/A TTGGT NTC_012_L2 FLD0024 FLD0048 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 1.000 3 pass no call 99 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 Blank TCACC T/C GGAGG NTC_012_L2 FLD0024 FLD0048 splice_region,synonymous TP53 c.672G>A c.672G>A(p.%3D) gaG/gaA chr17 7578177 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578177", "IGV") low 1.000 2 no call LowQual 22 TP53_E00001255919_1 ENSG00000141510 6 of 11 rs267605076, CS100446, TP53_g.12741G>C, TP53_g.12741G>A, TP53_g.12741G>T, COSM11451, COSM44754, COSM44945, COSM707896, COSM707899, COSM326732, COSM707897, COSM707900, COSM326731, COSM3970352, COSM1646846, COSM1646847, COSM1649395, COSM707898, COSM326733, COSM707901 uncertain_significance,not_provided 68 Blank CAGAC C/T TCAGG NTC_012_L2 FLD0024 FLD0048 synonymous TP53 c.459C>T c.459C>T(p.%3D) ccC/ccT chr17 7578471 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578471", "IGV") low 0.250 8 no call pass 38 TP53_E00001255919_6 ENSG00000141510 5 of 11 rs72661116, TP53_g.12447C>T, TP53_g.12447C>A, COSM404850, COSM43964, COSM44416, COSM404851, COSM1386817, COSM1386818, COSM404852, COSM1386820, COSM404854, COSM404853, COSM1386819 A:0.0002 27 Blank GTGCC G/A GGCGG NTC_012_L2 FLD0024 FLD0048 synonymous TP53 c.453C>T c.453C>T(p.%3D) ccC/ccT chr17 7578477 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578477", "IGV") low 0.250 8 no call pass 38 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12441C>A, TP53_g.12441C>T, TP53_g.12441C>G, COSM44749, COSM45594, COSM45464 33 Blank GGCGG G/A GGTGT NTC_012_L2 FLD0024 FLD0048 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") low 0.667 1.000 6 4 pass pass 53 71 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 Blank GGGGT G/C GGGGT NTC_012_L2 FLD0024 FLD0048 synonymous TP53 c.363T>C c.363T>C(p.%3D) tcT/tcC chr17 7579324 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7579324", "IGV") low 1.000 2 LowQual no call 22 TP53_E00001612188_1 ENSG00000141510 4 of 11 COSM1386835, COSM1386836, COSM1386837 45 Blank GTCAC A/G GACTT NTC_012_L2 FLD0024 FLD0048 synonymous TP53 c.243A>G c.243A>G(p.%3D) acA/acG chr17 7579444 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7579444", "IGV") low 1.000 2 no call pass 63 TP53_E00001612188_2 ENSG00000141510 4 of 11 57 Blank GCCGG T/C GTAGG NTC_012_L2 FLD0024 FLD0048 nonsynonymous TP53 c.226G>A p.A76T Gca/Aca chr17 7579461 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579461", "IGV") low 1.000 2 no call pass 63 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11457G>A tolerated(0.6) benign(0.005) 40 Blank TGGTG C/T AGGGG NTC_012_L2 FLD0024 FLD0048 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") low 1.000 2 no call pass 63 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 Blank CCACG G/C GGGGA NTC_012_L2 FLD0024 FLD0048 intron TP53 c.919+42G>A chr17 7576977 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576977", "IGV") low 1.000 2 no call LowQual 22 TP53_E00001789298_2 ENSG00000141510 8 of 10 52 Blank AACTG C/T ACCCT NTC_012_L2 FLD0024 FLD0048 synonymous TP53 c.888C>T c.888C>T(p.%3D) caC/caT chr17 7577050 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577050", "IGV") low 0.500 3 no call LowQual 12 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs758395031, TP53_g.13868C>T, TP53_g.13868C>G, COSM45328 28 Blank TCGTG G/A TGAGG CMDL140013 FLD0049 FLD0073 intron EGFR c.2284-60T>C chr7 55248926 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55248926", "IGV") low 0.667 3 no call pass 46 EGFR_E00001601336_1 18199332, 21869887 ENSG00000146648 19 of 27 rs10241451 C:0.1743 6 FFPE GTCCA T/C GTGCC CMDL140013 FLD0049 FLD0073 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") low 1.000 3 no call pass 97 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140013 FLD0049 FLD0073 synonymous EGFR c.2346C>T c.2346C>T(p.%3D) ctC/ctT chr7 55249048 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249048", "IGV") medium 0.521 1044 pass no call 20093 EGFR_E00001601336_2 ENSG00000146648 20 of 28 27 FFPE TGCCT C/T ACCTC CMDL140013 FLD0049 FLD0073 synonymous EGFR c.2352C>T c.2352C>T(p.%3D) tcC/tcT chr7 55249054 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249054", "IGV") medium 0.187 1531 no call pass 7073 EGFR_E00001601336_2 ENSG00000146648 20 of 28 33 FFPE ACCTC C/T ACCGT CMDL140013 FLD0049 FLD0073 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.691 0.649 1080 1586 pass pass 28478 40959 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140013 FLD0049 FLD0073 synonymous EGFR c.2395C>T c.2395C>T(p.%3D) Ctg/Ttg chr7 55249097 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249097", "IGV") medium 0.463 3021 no call pass 25109 EGFR_E00001601336_2 ENSG00000146648 20 of 28 76 FFPE GCCTC C/T TGGAC CMDL140013 FLD0049 FLD0073 nonsynonymous EGFR c.2464G>A p.A822T Gca/Aca chr7 55249166 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249166", "IGV") medium 0.296 997 pass no call 8470 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs397517125 deleterious(0) possibly_damaging(0.76) uncertain_significance 29 FFPE AGATC G/A CAAAG CMDL140013 FLD0049 FLD0073 splice_region,intron EGFR c.2470-7G>A chr7 55259405 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259405", "IGV") low 0.182 3549 no call QD 3503 EGFR_E00001681524_1 ENSG00000146648 20 of 27 34 FFPE TCTCT G/A TTTCA CMDL140013 FLD0049 FLD0073 nonsynonymous EGFR c.2486A>G p.E829G gAg/gGg chr7 55259428 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55259428", "IGV") low 0.155 3549 no call QD 1279 EGFR_E00001681524_1 ENSG00000146648 21 of 28 deleterious(0) probably_damaging(0.999) 57 FFPE CTTGG A/G GGACC CMDL140013 FLD0049 FLD0073 nonsynonymous EGFR c.2518G>A p.A840T Gcc/Acc chr7 55259460 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259460", "IGV") low 0.203 790 QD no call 1094 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs143884981, COSM85961 deleterious(0) probably_damaging(0.995) 44 FFPE TGGCA G/A CCAGG CMDL140013 FLD0049 FLD0073 synonymous EGFR c.2526C>T c.2526C>T(p.%3D) aaC/aaT chr7 55259468 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259468", "IGV") medium 0.219 790 pass no call 2434 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM3394833 52 FFPE AGGAA C/T GTACT CMDL140013 FLD0049 FLD0073 nonsynonymous EGFR c.3134C>T p.S1045F tCc/tTc chr7 55269447 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269447", "IGV") low 0.189 3202 no call QD 3429 EGFR_E00001773562_1 ENSG00000146648 26 of 28 tolerated(0.14) possibly_damaging(0.886) 48 FFPE CAATT C/T CACCG CMDL140013 FLD0049 FLD0073 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.996 0.994 1309 712 pass pass 55472 30000 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140013 FLD0049 FLD0073 synonymous EGFR c.2823C>T c.2823C>T(p.%3D) atC/atT chr7 55266531 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266531", "IGV") medium 0.493 714 no call pass 12208 EGFR_E00001779947_1 ENSG00000146648 23 of 28 rs757493321 21 FFPE ACCAT C/T GATGT CMDL140013 FLD0049 FLD0073 intron EGFR c.2848+12G>A chr7 55266568 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266568", "IGV") low 0.177 3718 no call QD 3305 EGFR_E00001779947_2 ENSG00000146648 23 of 27 56 FFPE GACTG G/A TGGGT CMDL140013 FLD0049 FLD0073 intron EGFR c.2848+37G>A chr7 55266593 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266593", "IGV") low 0.210 2857 QD no call 4734 EGFR_E00001779947_2 ENSG00000146648 23 of 27 31 FFPE TAGCT G/A AGCCT CMDL140013 FLD0049 FLD0073 intron EGFR c.2849-36T>C chr7 55267973 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55267973", "IGV") low 0.094 1468 no call QD 661 EGFR_E00001790701_1 ENSG00000146648 23 of 27 15 FFPE CAGTG T/C TCTAA CMDL140013 FLD0049 FLD0073 synonymous EGFR c.2895C>T c.2895C>T(p.%3D) atC/atT chr7 55268055 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268055", "IGV") low 0.228 2948 no call QD 5467 EGFR_E00001790701_1 ENSG00000146648 24 of 28 59 FFPE TTGAT C/T ATCGA CMDL140013 FLD0049 FLD0073 nonsynonymous EGFR c.2924C>T p.P975L cCc/cTc chr7 55268084 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268084", "IGV") low 0.081 1484 no call QD 767 EGFR_E00001790701_1 ENSG00000146648 24 of 28 deleterious(0) probably_damaging(1) 30 FFPE AGACC C/T CCAGC CMDL140013 FLD0049 FLD0073 synonymous EGFR c.2925C>T c.2925C>T(p.%3D) ccC/ccT chr7 55268085 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268085", "IGV") low 0.097 1483 no call QD 1748 EGFR_E00001790701_1 ENSG00000146648 24 of 28 rs778672343 29 FFPE GACCC C/T CAGCG CMDL140013 FLD0049 FLD0073 synonymous EGFR c.2934C>T c.2934C>T(p.%3D) taC/taT chr7 55268094 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268094", "IGV") low 0.082 1480 no call QD 804 EGFR_E00001790701_1 ENSG00000146648 24 of 28 20 FFPE CGCTA C/T CTTGT CMDL140013 FLD0049 FLD0073 synonymous EGFR c.2937T>C c.2937T>C(p.%3D) ctT/ctC chr7 55268097 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55268097", "IGV") low 0.103 913 QD no call 930 EGFR_E00001790701_1 ENSG00000146648 24 of 28 17 FFPE TACCT T/C GTCAT CMDL140013 FLD0049 FLD0073 synonymous EGFR c.2940C>T c.2940C>T(p.%3D) gtC/gtT chr7 55268100 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268100", "IGV") low 0.095 1480 no call QD 1288 EGFR_E00001790701_1 ENSG00000146648 24 of 28 14 FFPE CTTGT C/T ATTCA CMDL140013 FLD0049 FLD0073 stop_gained,splice_region EGFR c.2944C>T p.Q982* Cag/Tag chr7 55268104 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268104", "IGV") low 0.091 913 QD no call 420 EGFR_E00001790701_1 ENSG00000146648 24 of 28 COSM3923816 10 FFPE TCATT C/T AGGTA CMDL140013 FLD0049 FLD0073 nonsynonymous EGFR c.3025G>A p.D1009N Gac/Aac chr7 55268959 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268959", "IGV") low 0.146 3517 no call QD 1957 EGFR_E00001801208_2 ENSG00000146648 25 of 28 rs148019583, COSM3639757 deleterious(0.03) possibly_damaging(0.813) 21 FFPE TGGAC G/A ACGTG CMDL140013 FLD0049 FLD0073 synonymous EGFR c.3105G>A c.3105G>A(p.%3D) ctG/ctA chr7 55269039 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269039", "IGV") low 0.145 3517 no call QD 1563 EGFR_E00001801208_2 ENSG00000146648 25 of 28 40 FFPE CTCCT G/A AGCTC CMDL140013 FLD0049 FLD0073 intron TP53 c.97-36C>T chr17 7579626 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579626", "IGV") low 0.921 27 no call pass 554 EXP0116_TP53_E3 ENSG00000141510 3 of 10 50 FFPE ACCAG G/A TCCTC CMDL140013 FLD0049 FLD0073 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") low 0.250 7 pass no call 41 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL140013 FLD0049 FLD0073 synonymous KRAS c.69A>G c.69A>G(p.%3D) ctA/ctG chr12 25398250 T C =hyperlink("http://localhost:60151/goto?locus=chr12:25398250", "IGV") low 0.161 2445 QD no call 1175 KRAS_AA_HS ENSG00000133703 2 of 6 COSM938160, COSM1360866 60 FFPE TGAAT T/C AGCTG CMDL140013 FLD0049 FLD0073 nonsynonymous KRAS c.53C>T p.A18V gCc/gTc chr12 25398266 G A =hyperlink("http://localhost:60151/goto?locus=chr12:25398266", "IGV") medium 0.353 3653 no call pass 20390 KRAS_AA_HS ENSG00000133703 2 of 6 COSM542 deleterious(0) probably_damaging(0.985) 44 FFPE TCAAG G/A CACTC CMDL140013 FLD0049 FLD0073 synonymous KRAS c.45C>T c.45C>T(p.%3D) ggC/ggT chr12 25398274 G A =hyperlink("http://localhost:60151/goto?locus=chr12:25398274", "IGV") low 0.178 3653 no call QD 2747 KRAS_AA_HS ENSG00000133703 2 of 6 COSM1360879, COSM1360878 36 FFPE CTCTT G/A CCTAC CMDL140013 FLD0049 FLD0073 intron PIK3CA c.1540-27T>A chr3 178935971 T A =hyperlink("http://localhost:60151/goto?locus=chr3:178935971", "IGV") medium 0.487 965 no call pass 17120 PIK3CA_Ex10_gap ENSG00000121879 9 of 20 7 FFPE AAAGC T/A ATATA CMDL140013 FLD0049 FLD0073 synonymous PIK3CA c.1641G>A c.1641G>A(p.%3D) gaG/gaA chr3 178936099 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936099", "IGV") medium 0.479 964 no call pass 16770 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM729820, COSM729819 28 FFPE CAGGA G/A AAAGA CMDL140013 FLD0049 FLD0073 intron PTEN c.802-159T>C chr10 89720492 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720492", "IGV") medium 0.994 1166 pass no call 49703 PTEN_E00001156315_1m ENSG00000171862 7 of 8 12 FFPE GTCTT T/C GTGTT CMDL140013 FLD0049 FLD0073 intron PTEN c.802-9T>C chr10 89720642 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720642", "IGV") medium 0.972 1088 pass no call 37024 PTEN_E00001156315_1m ENSG00000171862 7 of 8 43 FFPE TTTTT T/C TTTTT CMDL140013 FLD0049 FLD0073 splice_acceptor PTEN c.802-2A>G chr10 89720649 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89720649", "IGV") low 0.134 1088 QD no call 1375 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs587782455, COSM13731 pathogenic 36 FFPE TTTTT A/G GGACA CMDL140013 FLD0049 FLD0073 nonsynonymous PTEN c.902A>T p.D301V gAt/gTt chr10 89720751 A T =hyperlink("http://localhost:60151/goto?locus=chr10:89720751", "IGV") medium 0.178 1829 pass no call 7007 PTEN_E00001156315_7 ENSG00000171862 8 of 9 tolerated(0.12) benign(0.079) 19 FFPE AATCG A/T TAGCA CMDL140013 FLD0049 FLD0073 nonsynonymous PTEN c.649G>A p.V217I Gtc/Atc chr10 89717624 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717624", "IGV") low 0.169 2762 QD no call 1922 PTEN_E00001156321_1 ENSG00000171862 7 of 9 rs121909234, COSM5058 tolerated(0.66) benign(0.122) pathogenic 54 FFPE TTGTG G/A TCTGC CMDL140013 FLD0049 FLD0073 synonymous PTEN c.658C>T c.658C>T(p.%3D) Cta/Tta chr10 89717633 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717633", "IGV") medium 0.248 2762 pass no call 19117 PTEN_E00001156321_1 ENSG00000171862 7 of 9 63 FFPE GCCAG C/T TAAAG CMDL140013 FLD0049 FLD0073 nonsynonymous PTEN c.664G>A p.V222M Gtg/Atg chr10 89717639 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717639", "IGV") low 0.183 3561 no call QD 4486 PTEN_E00001156321_1 ENSG00000171862 7 of 9 COSM1561200 tolerated(0.07) benign(0.222) 68 FFPE TAAAG G/A TGAAG CMDL140013 FLD0049 FLD0073 nonsynonymous PTEN c.676T>G p.S226A Tcc/Gcc chr10 89717651 T G =hyperlink("http://localhost:60151/goto?locus=chr10:89717651", "IGV") low 0.205 2762 QD no call 5463 PTEN_E00001156321_1 ENSG00000171862 7 of 9 tolerated(0.19) benign(0.016) 56 FFPE TATAT T/G CCTCC CMDL140013 FLD0049 FLD0073 synonymous PTEN c.708C>T c.708C>T(p.%3D) gaC/gaT chr10 89717683 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717683", "IGV") medium 0.244 2762 pass no call 20610 PTEN_E00001156321_1 ENSG00000171862 7 of 9 24 FFPE GAAGA C/T AAGTT CMDL140013 FLD0049 FLD0073 synonymous PTEN c.720C>T c.720C>T(p.%3D) taC/taT chr10 89717695 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717695", "IGV") medium 0.240 2762 pass no call 20674 PTEN_E00001156321_1 ENSG00000171862 7 of 9 CM110218, rs190070312, COSM921124, COSM921125 likely_benign T:0.0002 12 FFPE ATGTA C/T TTTGA CMDL140013 FLD0049 FLD0073 nonsynonymous PTEN c.737C>T p.P246L cCg/cTg chr10 89717712 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717712", "IGV") low 0.200 2696 no call QD 3909 PTEN_E00001156321_2 ENSG00000171862 7 of 9 rs587782350, CM991083, COSM5111 tolerated(0.06) benign(0.132) pathogenic 64 FFPE TCAGC C/T GTTAC CMDL140013 FLD0049 FLD0073 synonymous PTEN c.768G>A c.768G>A(p.%3D) gaG/gaA chr10 89717743 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717743", "IGV") low 0.199 2696 no call QD 3463 PTEN_E00001156321_2 ENSG00000171862 7 of 9 33 FFPE GTAGA G/A TTCTT CMDL140013 FLD0049 FLD0073 intron PTEN c.801+98C>T chr10 89717874 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717874", "IGV") medium 0.407 2494 pass no call 17172 PTEN_E00001156321_4m ENSG00000171862 7 of 8 60 FFPE GTTTT C/T TATTA CMDL140013 FLD0049 FLD0073 synonymous PTEN c.537C>T c.537C>T(p.%3D) agC/agT chr10 89711919 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711919", "IGV") medium 0.228 1704 no call pass 10031 PTEN_E00001156327_4 ENSG00000171862 6 of 9 rs779349848 11 FFPE TATAG C/T TACCT CMDL140013 FLD0049 FLD0073 nonsynonymous PTEN c.407G>A p.C136Y tGt/tAt chr10 89692923 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692923", "IGV") low 0.333 5 LowQual no call 27 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CD110173, CM983501, COSM5228, COSM12734 deleterious(0.04) possibly_damaging(0.634) 60 FFPE GATAT G/A TGCAT CMDL140013 FLD0049 FLD0073 intron PTEN c.253+55C>T chr10 89690901 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89690901", "IGV") low 0.158 4440 no call QD 2888 PTEN_E00001156337_4 ENSG00000171862 4 of 8 11 FFPE TGTAT C/T TTACT CMDL140013 FLD0049 FLD0073 splice_region,intron PTEN c.165-6T>C chr10 89685264 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89685264", "IGV") medium 0.448 2936 pass no call 24064 PTEN_E00001156344_1 ENSG00000171862 2 of 8 65 FFPE TTTGT T/C TTAAG CMDL140013 FLD0049 FLD0073 nonsynonymous PTEN c.101C>T p.A34V gCt/gTt chr10 89653803 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653803", "IGV") medium 0.407 3249 no call pass 21226 PTEN_E00001156351_1 ENSG00000171862 2 of 9 CM991079, COSM921061, COSM86058 deleterious(0) probably_damaging(0.925) 36 FFPE TATTG C/T TATGG CMDL140013 FLD0049 FLD0073 nonsynonymous PTEN c.154G>A p.D52N Gat/Aat chr10 89653856 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89653856", "IGV") medium 0.990 2068 pass no call 60198 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM5059 deleterious(0.02) possibly_damaging(0.876) 41 FFPE TTGAT G/A ATGTA CMDL140013 FLD0049 FLD0073 nonsynonymous PTEN c.157G>A p.V53I Gta/Ata chr10 89653859 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89653859", "IGV") medium 0.354 3249 no call pass 17352 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM1349480 tolerated(0.05) possibly_damaging(0.764) 38 FFPE ATGAT G/A TAGTA CMDL140013 FLD0049 FLD0073 nonsynonymous PTEN c.1075G>A p.A359T Gct/Act chr10 89725092 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725092", "IGV") medium 0.856 3482 no call pass 76508 PTEN_E00001456541_1 ENSG00000171862 9 of 9 tolerated(0.18) benign(0.017) 69 FFPE CAGAG G/A CTAGC CMDL140013 FLD0049 FLD0073 nonsynonymous PTEN c.1082G>A p.S361N aGt/aAt chr10 89725099 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725099", "IGV") low 0.092 1927 no call QD 325 PTEN_E00001456541_2 ENSG00000171862 9 of 9 tolerated(0.13) benign(0.075) 11 FFPE TAGCA G/A TTCAA CMDL140013 FLD0049 FLD0073 nonsynonymous PTEN c.1099C>T p.P367S Cca/Tca chr10 89725116 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725116", "IGV") low 0.151 3204 QD no call 576 PTEN_E00001456541_2 ENSG00000171862 9 of 9 tolerated(0.22) benign(0.043) 28 FFPE TAACA C/T CAGAT CMDL140013 FLD0049 FLD0073 nonsynonymous PTEN c.1102G>A p.D368N Gat/Aat chr10 89725119 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725119", "IGV") low 0.146 3213 LowQual,QD no call 18 PTEN_E00001456541_2 ENSG00000171862 9 of 9 tolerated(0.08) possibly_damaging(0.905) 31 FFPE CACCA G/A ATGTT CMDL140013 FLD0049 FLD0073 nonsynonymous PTEN c.1160C>T p.P387L cCa/cTa chr10 89725177 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725177", "IGV") low 0.157 3732 no call QD 756 PTEN_E00001456541_2 ENSG00000171862 9 of 9 deleterious_low_confidence(0.01) benign(0.282) 64 FFPE TGATC C/T AGAGA CMDL140013 FLD0049 FLD0073 intron TP53 c.672+21C>T chr17 7578156 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578156", "IGV") low 0.161 1567 QD no call 1006 TP53_E00001255919_1 ENSG00000141510 6 of 10 rs762077893 47 FFPE CCAGA G/A ACCCC CMDL140013 FLD0049 FLD0073 nonsynonymous TP53 c.661G>A p.E221K Gag/Aag chr17 7578188 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578188", "IGV") low 0.133 2296 no call QD 505 TP53_E00001255919_1 ENSG00000141510 6 of 11 TP53_g.12730G>T, TP53_g.12730G>A, TP53_g.12730del, TP53_g.12730G>C, COSM44817, COSM44853, COSM44276, COSM126982, COSM126983, COSM3937611, COSM1646845, COSM126984 deleterious(0) possibly_damaging(0.892) 65 FFPE CGGCT C/T ATAGG CMDL140013 FLD0049 FLD0073 synonymous TP53 c.654G>A c.654G>A(p.%3D) gtG/gtA chr17 7578195 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578195", "IGV") medium 0.112 2296 no call pass 5180 TP53_E00001255919_1 ENSG00000141510 6 of 11 rs753630563, TP53_g.12723G>A, COSM45923 likely_benign 58 FFPE TAGGG C/T ACCAC CMDL140013 FLD0049 FLD0073 nonsynonymous TP53 c.652G>A p.V218M Gtg/Atg chr17 7578197 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578197", "IGV") medium 0.113 2296 no call pass 5180 TP53_E00001255919_1 ENSG00000141510 6 of 11 TP53_g.12721G>T, TP53_g.12721G>C, TP53_g.12721G>A, TP53_g.12721del, COSM44683, COSM1324795, COSM44159, COSM1324796, COSM1324797, COSM1324799, COSM1324798 deleterious(0) probably_damaging(1) 56 FFPE GGGCA C/T CACCA CMDL140013 FLD0049 FLD0073 nonsynonymous TP53 c.619G>A p.D207N Gat/Aat chr17 7578230 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578230", "IGV") medium 0.231 1567 pass no call 3712 TP53_E00001255919_1 ENSG00000141510 6 of 11 TP53_g.12688G>A, TP53_g.12688G>C, TP53_g.12688G>T, TP53_g.12688del, COSM179817, COSM45289, COSM179819, COSM179818, COSM179820, COSM179821 tolerated(0.06) benign(0.054) 23 FFPE GTCAT C/T CAAAT CMDL140013 FLD0049 FLD0073 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") medium 0.270 1012 pass no call 3114 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140013 FLD0049 FLD0073 nonsynonymous TP53 c.53C>T p.T18I aCa/aTa chr17 7579860 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579860", "IGV") low 0.161 1012 QD no call 663 TP53_E00001596491_1 ENSG00000141510 2 of 11 deleterious(0) probably_damaging(0.988) 63 FFPE AAAAT G/A TTTCC CMDL140013 FLD0049 FLD0073 5_prime_UTR TP53 c.-9G>A chr17 7579921 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579921", "IGV") low 0.917 12 no call pass 420 TP53_E00001596491_1 ENSG00000141510 2 of 11 2 FFPE AGTGA C/T CCGGA CMDL140013 FLD0049 FLD0073 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") medium 0.849 0.847 99 252 pass pass 2588 5411 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140013 FLD0049 FLD0073 intron TP53 c.782+38G>A chr17 7577461 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577461", "IGV") low 0.113 1133 no call QD 1661 TP53_E00001665758_1 ENSG00000141510 7 of 10 12 FFPE GGGCA C/T AGCAG CMDL140013 FLD0049 FLD0073 intron TP53 c.782+10C>T chr17 7577489 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577489", "IGV") low 0.078 2520 QD no call 267 TP53_E00001665758_1 ENSG00000141510 7 of 10 rs200277687, TP53_g.13429C>T, TP53_g.13429C>A, COSM46119 A:0.0002 40 FFPE CAAGT G/A GCTCC CMDL140013 FLD0049 FLD0073 intron TP53 c.1100+25G>A chr17 7573902 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573902", "IGV") high 0.147 0.159 835 1079 pass pass 1940 3340 TP53_E00001728015_1 ENSG00000141510 10 of 10 22 FFPE TAGGG C/T CAGGA CMDL140013 FLD0049 FLD0073 nonsynonymous TP53 c.1045G>A p.E349K Gaa/Aaa chr17 7573982 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573982", "IGV") low 0.159 2201 no call QD 1222 TP53_E00001728015_1 ENSG00000141510 10 of 11 TP53_g.16936del, TP53_g.16936G>T, COSM10770, COSM1386549, COSM46056, COSM1735857, COSM140784, COSM1386550 deleterious(0) probably_damaging(1) 55 FFPE GAGTT C/T CAAGG CMDL140013 FLD0049 FLD0073 nonsynonymous TP53 c.1028A>G p.E343G gAg/gGg chr17 7573999 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7573999", "IGV") low 0.161 1672 QD no call 1257 TP53_E00001728015_1 ENSG00000141510 10 of 11 TP53_g.16919A>G, TP53_g.16919del, COSM1386557, COSM1386558 deleterious(0.01) possibly_damaging(0.672) 38 FFPE TCAGC T/C CTCGG CMDL140013 FLD0049 FLD0073 nonsynonymous TP53 c.1001G>A p.G334E gGg/gAg chr17 7574026 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7574026", "IGV") medium 0.159 826 pass no call 2231 TP53_E00001728015_1 ENSG00000141510 10 of 11 TP53_g.16892G>T, COSM330687, COSM11514, COSM323935, COSM330688 deleterious(0) probably_damaging(0.992) 11 FFPE CACGC C/T CACGG CMDL140013 FLD0049 FLD0073 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.819 3086 no call pass 64343 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140013 FLD0049 FLD0073 3_prime_UTR TP53 c.*10C>T chr17 7572917 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572917", "IGV") low 0.180 1697 QD no call 1660 TP53_E00001757276_1 ENSG00000141510 11 of 11 48 FFPE AAGAA G/A TGGAG CMDL140013 FLD0049 FLD0073 nonsynonymous TP53 c.1153T>C p.F385L Ttc/Ctc chr17 7572956 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7572956", "IGV") medium 0.290 3086 no call pass 12375 TP53_E00001757276_1 ENSG00000141510 11 of 11 TP53_g.17962T>C tolerated(0.43) benign(0.001) 55 FFPE CTTGA A/G CATGA CMDL140013 FLD0049 FLD0073 synonymous TP53 c.1137C>T c.1137C>T(p.%3D) cgC/cgT chr17 7572972 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572972", "IGV") medium 0.285 1697 pass no call 6247 TP53_E00001757276_1 ENSG00000141510 11 of 11 COSM1386542, COSM1386543 39 FFPE TTATG G/A CGGGA CMDL140013 FLD0049 FLD0073 synonymous TP53 c.1104C>T c.1104C>T(p.%3D) caC/caT chr17 7573005 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573005", "IGV") low 0.084 1448 no call QD 485 TP53_E00001757276_1 ENSG00000141510 11 of 11 TP53_g.17913del 6 FFPE TTCAG G/A TGGCT CMDL140013 FLD0049 FLD0073 splice_region,intron TP53 c.993+4C>T chr17 7576849 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576849", "IGV") low 0.172 3291 QD no call 2808 TP53_E00001789298_1 ENSG00000141510 9 of 10 43 FFPE ACTTA G/A TACCT CMDL140013 FLD0049 FLD0073 synonymous TP53 c.984C>T c.984C>T(p.%3D) ttC/ttT chr17 7576862 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576862", "IGV") low 0.182 3291 QD no call 3030 TP53_E00001789298_1 ENSG00000141510 9 of 11 TP53_g.14056C>T, COSM44833 56 FFPE AGGGT G/A AAATA CMDL140013 FLD0049 FLD0073 nonsynonymous TP53 c.974G>A p.G325E gGa/gAa chr17 7576872 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576872", "IGV") low 0.157 3966 no call QD 1245 TP53_E00001789298_1 ENSG00000141510 9 of 11 CM920680, rs121912659, TP53_g.14046G>C, TP53_g.14046G>A, TP53_g.14046G>T, COSM46030, COSM44060, COSM46225 tolerated(1) benign(0.029) uncertain_significance,pathogenic 66 FFPE ATTCT C/T CATCC CMDL140013 FLD0049 FLD0073 synonymous TP53 c.942C>T c.942C>T(p.%3D) tcC/tcT chr17 7576904 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576904", "IGV") medium 0.171 3291 pass no call 13655 TP53_E00001789298_1 ENSG00000141510 9 of 11 rs765930028, TP53_g.14014C>T, TP53_g.14014del 60 FFPE GGAGA G/A GAGCT CMDL140013 FLD0049 FLD0073 synonymous TP53 c.936C>T c.936C>T(p.%3D) acC/acT chr17 7576910 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576910", "IGV") medium 0.172 3291 pass no call 13655 TP53_E00001789298_1 ENSG00000141510 9 of 11 TP53_g.14008C>A, TP53_g.14008C>T, TP53_g.14008del, COSM44811, COSM45392, COSM45613, COSM2149481, COSM2149482 54 FFPE GAGCT G/A GTGTT CMDL140013 FLD0049 FLD0073 intron TP53 c.920-24C>T chr17 7576950 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576950", "IGV") medium 0.144 1970 no call pass 4906 TP53_E00001789298_1 ENSG00000141510 8 of 10 14 FFPE AAGGT G/A ATAAA CMDL140013 FLD0049 FLD0073 intron TP53 c.920-32A>G chr17 7576958 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7576958", "IGV") low 0.108 1630 QD no call 2103 TP53_E00001789298_1 ENSG00000141510 8 of 10 6 FFPE AAAAG T/C GAATC CMDL140013 FLD0049 FLD0073 intron TP53 c.920-9C>T chr17 7576935 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576935", "IGV") low 0.153 2608 QD no call 1324 TP53_E00001789298_2 ENSG00000141510 8 of 10 10 FFPE GGAAA G/A AGGCA CMDL140013 FLD0049 FLD0073 synonymous TP53 c.897G>A c.897G>A(p.%3D) ctG/ctA chr17 7577041 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577041", "IGV") low 0.180 2406 QD no call 2723 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13877G>T, TP53_g.13877G>C, COSM45659 19 FFPE GGGGG C/T AGCTC CMDL140013 FLD0049 FLD0073 nonsynonymous TP53 c.874A>G p.K292E Aaa/Gaa chr17 7577064 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7577064", "IGV") low 0.203 2405 QD no call 4038 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13854del, TP53_g.13854A>T, TP53_g.13854A>C, TP53_g.13854A>G, COSM44894, COSM44207, COSM44451, COSM1172458 tolerated(0.06) benign(0.248) 42 FFPE CCCTT T/C CTTGC CMDL140013 FLD0049 FLD0073 nonsynonymous TP53 c.869G>A p.R290H cGc/cAc chr17 7577069 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577069", "IGV") low 0.173 3105 no call QD 2693 TP53_E00001789298_3 25105660 ENSG00000141510 8 of 11 CM065493, CM993905, rs55819519, TP53_g.13849G>T, TP53_g.13849G>A, COSM44639, COSM44017, COSM1386594 tolerated(0.6) benign(0.004) uncertain_significance T:0.0002 47 FFPE TCTTG C/T GGAGA CMDL140029 FLD0050 FLD0074 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") low 0.750 2 pass no call 47 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140029 FLD0050 FLD0074 intron EGFR c.2702-11C>T chr7 55266399 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266399", "IGV") low 0.096 1468 QD no call 574 EGFR_E00001779947_1 ENSG00000146648 22 of 27 16 FFPE TGCTT C/T ATCCT CMDL140029 FLD0050 FLD0074 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.998 0.994 1469 1476 pass pass 63996 63161 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140029 FLD0050 FLD0074 intron TP53 c.97-44G>A chr17 7579634 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579634", "IGV") low 0.145 290 no call QD 197 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs762445877 58 FFPE CTCAG C/T CCCCC CMDL140029 FLD0050 FLD0074 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") medium 0.472 290 no call pass 3121 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL140029 FLD0050 FLD0074 intron PIK3CA c.1540-12T>C chr3 178935986 T C =hyperlink("http://localhost:60151/goto?locus=chr3:178935986", "IGV") low 0.093 623 no call QD 202 PIK3CA_Ex10_gap ENSG00000121879 9 of 20 22 FFPE ATTAT T/C TTATT CMDL140029 FLD0050 FLD0074 stop_gained PIK3CA c.1656G>A p.W552* tgG/tgA chr3 178936114 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936114", "IGV") low 0.107 614 no call QD 530 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM37025, COSM86991 13 FFPE CTATG G/A AGTCA CMDL140029 FLD0050 FLD0074 intron PTEN c.802-159T>C chr10 89720492 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720492", "IGV") medium 0.138 1121 pass no call 3248 PTEN_E00001156315_1m ENSG00000171862 7 of 8 12 FFPE GTCTT T/C GTGTT CMDL140029 FLD0050 FLD0074 intron PTEN c.802-142A>G chr10 89720509 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89720509", "IGV") medium 0.198 1121 pass no call 5674 PTEN_E00001156315_1m ENSG00000171862 7 of 8 29 FFPE TATTC A/G GAATA CMDL140029 FLD0050 FLD0074 intron PTEN c.802-136T>C chr10 89720515 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720515", "IGV") low 0.078 1097 no call QD 188 PTEN_E00001156315_1m ENSG00000171862 7 of 8 35 FFPE GAATA T/C CAAAT CMDL140029 FLD0050 FLD0074 intron PTEN c.802-46A>G chr10 89720605 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89720605", "IGV") low 0.124 1173 QD no call 1089 PTEN_E00001156315_1m ENSG00000171862 7 of 8 80 FFPE AATTA A/G ATATG CMDL140029 FLD0050 FLD0074 intron PTEN c.802-34C>T chr10 89720617 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720617", "IGV") low 0.192 74 no call QD 74 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs531071483 68 FFPE CATTT C/T ATTTC CMDL140029 FLD0050 FLD0074 intron PTEN c.802-24T>C chr10 89720627 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720627", "IGV") low 0.100 53 pass no call 127 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs772106902 58 FFPE CTTTT T/C CTTTT CMDL140029 FLD0050 FLD0074 splice_region,intron PTEN c.802-3T>C chr10 89720648 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720648", "IGV") low 0.054 74 no call pass 193 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs587780712, COSM5928 uncertain_significance 37 FFPE TTTTT T/C AGGAC CMDL140029 FLD0050 FLD0074 nonsynonymous,splice_region PTEN c.802G>A p.D268N Gac/Aac chr10 89720651 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720651", "IGV") low 0.220 74 no call pass 389 PTEN_E00001156315_1m ENSG00000171862 8 of 9 deleterious(0) benign(0.026) 34 FFPE TTTAG G/A ACAAA CMDL140029 FLD0050 FLD0074 nonsynonymous PTEN c.810G>A p.M270I atG/atA chr10 89720659 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720659", "IGV") low 0.174 53 pass no call 127 PTEN_E00001156315_1m ENSG00000171862 8 of 9 COSM921139 tolerated(0.06) benign(0.086) 26 FFPE AAAAT G/A TTTCA CMDL140029 FLD0050 FLD0074 nonsynonymous PTEN c.1013C>T p.S338F tCt/tTt chr10 89720862 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720862", "IGV") low 0.095 1993 QD no call 774 PTEN_E00001156315_7 ENSG00000171862 8 of 9 COSM1349622 deleterious(0) probably_damaging(0.998) 34 FFPE CTTTT C/T TCCAA CMDL140029 FLD0050 FLD0074 intron PTEN c.801+127C>T chr10 89717903 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717903", "IGV") low 0.084 1552 no call QD 325 PTEN_E00001156321_4m ENSG00000171862 7 of 8 31 FFPE TTACT C/T TGGCA CMDL140029 FLD0050 FLD0074 intron PTEN c.801+150G>A chr10 89717926 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717926", "IGV") low 0.075 1542 no call QD 200 PTEN_E00001156321_4m ENSG00000171862 7 of 8 8 FFPE TATAA G/A GGTAA CMDL140029 FLD0050 FLD0074 intron PTEN c.801+152G>A chr10 89717928 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717928", "IGV") low 0.139 1542 no call QD 2987 PTEN_E00001156321_4m ENSG00000171862 7 of 8 6 FFPE TAAGG G/A TAAAT CMDL140029 FLD0050 FLD0074 nonsynonymous PTEN c.352C>T p.H118Y Cat/Tat chr10 89692868 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692868", "IGV") low 0.087 1387 no call QD 621 PTEN_E00001156330_3 ENSG00000171862 5 of 9 deleterious(0) benign(0.309) 5 FFPE ACAAT C/T ATGTT CMDL140029 FLD0050 FLD0074 synonymous PTEN c.384G>A c.384G>A(p.%3D) aaG/aaA chr10 89692900 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692900", "IGV") medium 0.332 2619 pass no call 19771 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5193, COSM1349527, COSM242607 37 FFPE GGAAA G/A GGACG CMDL140029 FLD0050 FLD0074 nonsynonymous PTEN c.402G>A p.M134I atG/atA chr10 89692918 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692918", "IGV") low 0.180 2619 QD no call 3178 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM921092, COSM1561208 deleterious(0) possibly_damaging(0.824) 55 FFPE GTAAT G/A ATATG CMDL140029 FLD0050 FLD0074 nonsynonymous PTEN c.457G>A p.D153N Gat/Aat chr10 89692973 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692973", "IGV") low 0.176 2619 QD no call 2145 PTEN_E00001156330_3 ENSG00000171862 5 of 9 rs9651492, COSM5284, COSM5083 tolerated(0.41) benign(0.173) 52 FFPE CCCTA G/A ATTTC CMDL140029 FLD0050 FLD0074 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") medium 0.155 1048 no call pass 2604 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL140029 FLD0050 FLD0074 intron TP53 c.74+47C>T chr17 7579792 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579792", "IGV") low 0.148 2348 QD no call 1615 TP53_E00001596491_1 ENSG00000141510 2 of 10 15 FFPE GCTGG G/A GTTGG CMDL140029 FLD0050 FLD0074 intron TP53 c.74+43C>T chr17 7579796 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579796", "IGV") low 0.146 2068 no call QD 892 TP53_E00001596491_1 ENSG00000141510 2 of 10 19 FFPE GGGTT G/A GGGTG CMDL140029 FLD0050 FLD0074 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.998 0.994 2348 2068 pass pass 90811 76126 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140029 FLD0050 FLD0074 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") medium 0.280 2348 pass no call 9632 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL140029 FLD0050 FLD0074 synonymous TP53 c.64C>T c.64C>T(p.%3D) Cta/Tta chr17 7579849 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579849", "IGV") low 0.139 2068 no call QD 421 TP53_E00001596491_1 ENSG00000141510 2 of 11 72 FFPE CCATA G/A GTCTG CMDL140029 FLD0050 FLD0074 nonsynonymous TP53 c.59C>T p.S20L tCa/tTa chr17 7579854 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579854", "IGV") medium 0.148 2348 pass no call 7527 TP53_E00001596491_1 ENSG00000141510 2 of 11 tolerated(0.08) possibly_damaging(0.672) 69 FFPE GGTCT G/A AAAAT CMDL140029 FLD0050 FLD0074 stop_gained TP53 c.46C>T p.Q16* Cag/Tag chr17 7579867 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579867", "IGV") medium 0.146 2348 pass no call 7527 TP53_E00001596491_1 ENSG00000141510 2 of 11 COSM100007, COSM100010, COSM100008, COSM100009 56 FFPE TTCCT G/A ACTCA CMDL140029 FLD0050 FLD0074 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.994 0.990 770 700 pass pass 26248 24896 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140029 FLD0050 FLD0074 3_prime_UTR TP53 c.*49C>T chr17 7572878 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572878", "IGV") medium 0.321 1400 pass no call 14781 TP53_E00001757276_1 ENSG00000141510 11 of 11 9 FFPE GGAGG G/A AGAGA CMDL140029 FLD0050 FLD0074 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") medium 0.311 2829 pass no call 14780 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL140029 FLD0050 FLD0074 3_prime_UTR TP53 c.*24C>T chr17 7572903 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572903", "IGV") low 0.079 2533 no call QD 1672 TP53_E00001757276_1 ENSG00000141510 11 of 11 34 FFPE TGTCA G/A TGGGG CMDL140029 FLD0050 FLD0074 3_prime_UTR TP53 c.*22C>T chr17 7572905 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572905", "IGV") low 0.083 2533 no call QD 1672 TP53_E00001757276_1 ENSG00000141510 11 of 11 36 FFPE TCAGT G/A GGGAA CMDL140029 FLD0050 FLD0074 synonymous TP53 c.1155C>T c.1155C>T(p.%3D) ttC/ttT chr17 7572954 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572954", "IGV") low 0.076 2533 no call QD 821 TP53_E00001757276_1 ENSG00000141510 11 of 11 57 FFPE GTCTT G/A AACAT CMDL140029 FLD0050 FLD0074 nonsynonymous TP53 c.1147C>T p.L383F Ctc/Ttc chr17 7572962 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572962", "IGV") low 0.073 2533 no call QD 872 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs150842067, COSM307349 deleterious(0.02) benign(0.361) 49 FFPE CATGA G/A TTTTT CMDL140042 FLD0051 FLD0075 intron EGFR c.2284-34G>A chr7 55248952 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55248952", "IGV") medium 0.994 1125 no call pass 47857 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs202058122 32 FFPE CATGC G/A AAGCC CMDL140042 FLD0051 FLD0075 splice_region,synonymous EGFR c.2286A>G c.2286A>G(p.%3D) gaA/gaG chr7 55248988 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55248988", "IGV") medium 0.997 1994 pass no call 58943 EGFR_E00001601336_1 ENSG00000146648 20 of 28 68 FFPE CAGGA A/G GCCTA CMDL140042 FLD0051 FLD0075 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.989 0.983 978 1315 pass pass 41155 54484 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140042 FLD0051 FLD0075 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.995 0.994 1296 1505 pass pass 69432 85794 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140042 FLD0051 FLD0075 synonymous EGFR c.2400C>T c.2400C>T(p.%3D) gaC/gaT chr7 55249102 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249102", "IGV") low 0.136 2861 no call QD 381 EGFR_E00001601336_2 ENSG00000146648 20 of 28 81 FFPE CTGGA C/T TATGT CMDL140042 FLD0051 FLD0075 intron EGFR c.2626-45G>A chr7 55260414 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260414", "IGV") medium 0.227 1586 pass no call 8980 EGFR_E00001631695_1 ENSG00000146648 21 of 27 rs773138582 27 FFPE CAGAG G/A GAAAC CMDL140042 FLD0051 FLD0075 stop_gained EGFR c.2640G>A p.W880* tgG/tgA chr7 55260473 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260473", "IGV") low 0.190 3210 QD no call 3732 EGFR_E00001631695_1 ENSG00000146648 22 of 28 COSM3929122 80 FFPE AAGTG G/A ATGGC CMDL140042 FLD0051 FLD0075 nonsynonymous EGFR c.2643G>A p.M881I atG/atA chr7 55260476 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260476", "IGV") low 0.136 3695 no call QD 451 EGFR_E00001631695_1 ENSG00000146648 22 of 28 rs751549547 deleterious(0) benign(0.413) 77 FFPE TGGAT G/A GCATT CMDL140042 FLD0051 FLD0075 nonsynonymous EGFR c.2654C>T p.S885L tCa/tTa chr7 55260487 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260487", "IGV") medium 0.233 3210 pass no call 7434 EGFR_E00001631695_1 ENSG00000146648 22 of 28 rs397517137 deleterious(0.01) probably_damaging(1) uncertain_significance 66 FFPE GGAAT C/T AATTT CMDL140042 FLD0051 FLD0075 nonsynonymous EGFR c.2666G>A p.R889K aGa/aAa chr7 55260499 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260499", "IGV") low 0.099 3695 no call QD 878 EGFR_E00001631695_1 ENSG00000146648 22 of 28 tolerated(0.06) probably_damaging(0.996) 54 FFPE ACACA G/A AATCT CMDL140042 FLD0051 FLD0075 intron EGFR c.2470-14C>T chr7 55259398 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259398", "IGV") low 0.222 2622 QD no call 5167 EGFR_E00001681524_1 ENSG00000146648 20 of 27 27 FFPE AGGGT C/T TTCTC CMDL140042 FLD0051 FLD0075 synonymous EGFR c.2520C>T c.2520C>T(p.%3D) gcC/gcT chr7 55259462 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259462", "IGV") low 0.103 3170 no call QD 4367 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM707247 64 FFPE GCAGC C/T AGGAA CMDL140042 FLD0051 FLD0075 nonsynonymous EGFR c.2521A>G p.R841G Agg/Ggg chr7 55259463 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55259463", "IGV") low 0.108 3170 no call QD 4604 EGFR_E00001681524_1 ENSG00000146648 21 of 28 deleterious(0) probably_damaging(0.993) 63 FFPE CAGCC A/G GGAAC CMDL140042 FLD0051 FLD0075 synonymous EGFR c.2586G>A c.2586G>A(p.%3D) ctG/ctA chr7 55259528 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259528", "IGV") low 0.151 1841 no call QD 1625 EGFR_E00001681524_2 ENSG00000146648 21 of 28 44 FFPE CTGCT G/A GGTGC CMDL140042 FLD0051 FLD0075 nonsynonymous EGFR c.2596G>A p.E866K Gag/Aag chr7 55259538 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259538", "IGV") medium 0.147 0.233 1245 1841 QD pass 53 9606 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs756703787, COSM13198 deleterious(0) probably_damaging(0.982) 34 FFPE CGGAA G/A AGAAA CMDL140042 FLD0051 FLD0075 splice_region,synonymous EGFR c.2703G>A c.2703G>A(p.%3D) ggG/ggA chr7 55266411 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266411", "IGV") medium 0.169 1560 no call pass 4571 EGFR_E00001779947_1 ENSG00000146648 23 of 28 28 FFPE TCAGG G/A GTGAC CMDL140042 FLD0051 FLD0075 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.997 0.998 1361 1561 pass pass 59054 68119 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140042 FLD0051 FLD0075 nonsynonymous EGFR c.2724G>T p.M908I atG/atT chr7 55266432 G T =hyperlink("http://localhost:60151/goto?locus=chr7:55266432", "IGV") high 0.305 0.299 2742 3126 pass pass 14641 12620 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(0.999) 49 FFPE TTGAT G/T ACCTT CMDL140042 FLD0051 FLD0075 nonsynonymous EGFR c.2737A>G p.K913E Aag/Gag chr7 55266445 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55266445", "IGV") medium 0.308 2742 pass no call 14852 EGFR_E00001779947_1 ENSG00000146648 23 of 28 tolerated(0.05) probably_damaging(0.999) 62 FFPE GATCC A/G AGCCA CMDL140042 FLD0051 FLD0075 nonsynonymous EGFR c.2797C>T p.L933F Ctc/Ttc chr7 55266505 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266505", "IGV") low 0.090 3126 no call QD 1929 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(1) 47 FFPE AACGC C/T TCCCT CMDL140042 FLD0051 FLD0075 nonsynonymous EGFR c.2801C>T p.P934L cCt/cTt chr7 55266509 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266509", "IGV") low 0.088 3126 no call QD 1706 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(1) 43 FFPE CCTCC C/T TCAGC CMDL140042 FLD0051 FLD0075 intron EGFR c.2849-50C>T chr7 55267959 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55267959", "IGV") medium 0.136 1513 no call pass 3129 EGFR_E00001790701_1 ENSG00000146648 23 of 27 1 FFPE TTTAT C/T ATTTC CMDL140042 FLD0051 FLD0075 synonymous EGFR c.3039C>T c.3039C>T(p.%3D) gcC/gcT chr7 55268973 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268973", "IGV") low 0.093 3383 no call QD 1865 EGFR_E00001801208_2 ENSG00000146648 25 of 28 35 FFPE GATGC C/T GACGA CMDL140042 FLD0051 FLD0075 nonsynonymous TP53 c.107C>T p.P36L cCg/cTg chr17 7579580 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579580", "IGV") medium 0.915 137 pass no call 1902 EXP0116_TP53_E3 ENSG00000141510 4 of 11 rs587781866, TP53_g.11338C>A, TP53_g.11338C>T tolerated(0.38) benign(0) uncertain_significance 4 FFPE GGGAC G/A GCAAG CMDL140042 FLD0051 FLD0075 splice_acceptor TP53 c.97-1G>A chr17 7579591 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579591", "IGV") low 0.006 304 FS no call 1403 EXP0116_TP53_E3 ENSG00000141510 3 of 10 CS971912, TP53_g.11327G>A, TP53_g.11327G>C, COSM43759, COSM29761, COSM1610880, COSM437642, COSM218543, COSM1610881, COSM437643, COSM218542, COSM1610882, COSM3388237, COSM3717685, COSM3717684, COSM2745172 15 FFPE GGGGA C/T TGTAG CMDL140042 FLD0051 FLD0075 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") medium 0.943 304 pass no call 7405 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL140042 FLD0051 FLD0075 synonymous KRAS c.57G>A c.57G>A(p.%3D) ttG/ttA chr12 25398262 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398262", "IGV") low 0.087 3121 QD no call 1237 KRAS_AA_HS ENSG00000133703 2 of 6 rs121913538, COSM12703, COSM20818, COSM1360876, COSM1212766 48 FFPE ATCGT C/T AAGGC CMDL140042 FLD0051 FLD0075 synonymous KRAS c.48G>A c.48G>A(p.%3D) aaG/aaA chr12 25398271 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398271", "IGV") low 0.084 3121 QD no call 1237 KRAS_AA_HS ENSG00000133703 2 of 6 39 FFPE GCACT C/T TTGCC CMDL140042 FLD0051 FLD0075 nonsynonymous KRAS c.35G>A p.G12D gGt/gAt chr12 25398284 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") high 0.346 0.268 3121 3567 pass pass 20895 11295 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) benign(0.361) 26 FFPE CGCCA C/T CAGCT CMDL140042 FLD0051 FLD0075 nonsynonymous KRAS c.25G>A p.V9I Gtt/Att chr12 25398294 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398294", "IGV") low 0.139 3121 QD no call 763 KRAS_AA_HS ENSG00000133703 2 of 6 COSM1562184, COSM1360890, COSM1360889, COSM1562183 deleterious(0.02) possibly_damaging(0.789) 16 FFPE TCCAA C/T TACCA CMDL140042 FLD0051 FLD0075 synonymous PIK3CA c.1617T>C c.1617T>C(p.%3D) ccT/ccC chr3 178936075 T C =hyperlink("http://localhost:60151/goto?locus=chr3:178936075", "IGV") low 0.177 1228 no call QD 1078 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM1420860, COSM1420859 52 FFPE GATCC T/C CTCTC CMDL140042 FLD0051 FLD0075 synonymous PIK3CA c.1635G>A c.1635G>A(p.%3D) gaG/gaA chr3 178936093 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936093", "IGV") medium 0.226 723 no call pass 4887 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 rs121913275, COSM27374, COSM765, COSM1716554, COSM327064 34 FFPE ACTGA G/A CAGGA CMDL140042 FLD0051 FLD0075 synonymous PIK3CA c.1641G>A c.1641G>A(p.%3D) gaG/gaA chr3 178936099 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936099", "IGV") medium 0.253 604 no call pass 5069 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM729820, COSM729819 28 FFPE CAGGA G/A AAAGA CMDL140042 FLD0051 FLD0075 nonsynonymous PIK3CA c.3129G>T p.M1043I atG/atT chr3 178952074 G T =hyperlink("http://localhost:60151/goto?locus=chr3:178952074", "IGV") high 0.157 0.139 1500 1734 pass pass 4939 4268 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 rs121913283, COSM29313, COSM94984, COSM773, COSM419700, COSM446027, COSM94985 tolerated(0.11) benign(0.054) likely_pathogenic 17 FFPE CAAAT G/T AATGA CMDL140042 FLD0051 FLD0075 intron PTEN c.802-143C>T chr10 89720508 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720508", "IGV") medium 0.994 987 pass no call 41926 PTEN_E00001156315_1m ENSG00000171862 7 of 8 28 FFPE TTATT C/T AGAAT CMDL140042 FLD0051 FLD0075 intron PTEN c.802-58C>G chr10 89720593 C G =hyperlink("http://localhost:60151/goto?locus=chr10:89720593", "IGV") medium 0.844 1170 no call pass 32447 PTEN_E00001156315_1m ENSG00000171862 7 of 8 92 FFPE TAAAA C/G ATCAT CMDL140042 FLD0051 FLD0075 nonsynonymous PTEN c.809T>A p.M270K aTg/aAg chr10 89720658 T A =hyperlink("http://localhost:60151/goto?locus=chr10:89720658", "IGV") low 0.994 58 no call pass 2582 PTEN_E00001156315_1m ENSG00000171862 8 of 9 COSM921138 deleterious(0) possibly_damaging(0.593) 27 FFPE CAAAA T/A GTTTC CMDL140042 FLD0051 FLD0075 nonsynonymous PTEN c.911G>A p.C304Y tGc/tAc chr10 89720760 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720760", "IGV") low 0.113 2176 no call QD 2078 PTEN_E00001156315_7 ENSG00000171862 8 of 9 tolerated(1) benign(0) 28 FFPE CATTT G/A CAGTA CMDL140042 FLD0051 FLD0075 stop_gained PTEN c.654C>A p.C218* tgC/tgA chr10 89717629 C A =hyperlink("http://localhost:60151/goto?locus=chr10:89717629", "IGV") high 0.696 0.694 3101 3481 pass pass 60230 60313 PTEN_E00001156321_1 ENSG00000171862 7 of 9 COSM5302, COSM1717477 59 FFPE GTCTG C/A CAGCT CMDL140042 FLD0051 FLD0075 nonsynonymous PTEN c.686C>T p.S229L tCa/tTa chr10 89717661 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717661", "IGV") low 0.214 2933 QD no call 4876 PTEN_E00001156321_2 ENSG00000171862 7 of 9 CM110118, COSM5295 tolerated(0.56) benign(0.002) 22 FFPE CAATT C/T AGGAC CMDL140042 FLD0051 FLD0075 nonsynonymous PTEN c.688G>A p.G230R Gga/Aga chr10 89717663 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717663", "IGV") low 0.188 2933 QD no call 2538 PTEN_E00001156321_2 ENSG00000171862 7 of 9 COSM5132, COSM1349575 tolerated(0.34) benign(0.102) 24 FFPE ATTCA G/A GACCC CMDL140042 FLD0051 FLD0075 synonymous PTEN c.747G>A c.747G>A(p.%3D) gtG/gtA chr10 89717722 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717722", "IGV") medium 0.315 2933 pass no call 13618 PTEN_E00001156321_2 ENSG00000171862 7 of 9 54 FFPE CCTGT G/A TGTGG CMDL140042 FLD0051 FLD0075 nonsynonymous PTEN c.760A>G p.K254E Aaa/Gaa chr10 89717735 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717735", "IGV") low 0.200 3314 no call QD 4497 PTEN_E00001156321_2 ENSG00000171862 7 of 9 COSM5325, COSM5069 deleterious(0) possibly_damaging(0.854) 41 FFPE ATATC A/G AAGTA CMDL140042 FLD0051 FLD0075 intron PTEN c.801+17C>T chr10 89717793 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717793", "IGV") medium 0.378 1502 no call pass 18378 PTEN_E00001156321_4m ENSG00000171862 7 of 8 24 FFPE ACTTT C/T ATTGG CMDL140042 FLD0051 FLD0075 intron PTEN c.801+98C>T chr10 89717874 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717874", "IGV") medium 0.275 2569 pass no call 8191 PTEN_E00001156321_4m ENSG00000171862 7 of 8 60 FFPE GTTTT C/T TATTA CMDL140042 FLD0051 FLD0075 nonsynonymous PTEN c.559G>A p.D187N Gat/Aat chr10 89711941 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89711941", "IGV") medium 0.133 3268 no call pass 8489 PTEN_E00001156327_4 ENSG00000171862 6 of 9 COSM5849, COSM1577268 tolerated(0.49) benign(0.002) 33 FFPE ATCTG G/A ATTAT CMDL140042 FLD0051 FLD0075 nonsynonymous PTEN c.571G>A p.V191M Gtg/Atg chr10 89711953 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89711953", "IGV") medium 0.133 3268 no call pass 8940 PTEN_E00001156327_4 ENSG00000171862 6 of 9 tolerated(0.06) benign(0.287) 45 FFPE GACCA G/A TGGCA CMDL140042 FLD0051 FLD0075 nonsynonymous PTEN c.346G>A p.D116N Gac/Aac chr10 89692862 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692862", "IGV") low 0.122 3562 no call QD 2494 PTEN_E00001156330_1 ENSG00000171862 5 of 9 tolerated(0.45) benign(0.015) 37 FFPE AAGAT G/A ACAAT CMDL140042 FLD0051 FLD0075 synonymous PTEN c.369C>T c.369C>T(p.%3D) caC/caT chr10 89692885 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692885", "IGV") medium 0.993 1173 no call pass 49557 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CM1010010 22 FFPE ATTCA C/T TGTAA CMDL140042 FLD0051 FLD0075 intron PTEN c.165-17G>A chr10 89685253 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89685253", "IGV") low 0.191 3476 no call QD 2484 PTEN_E00001156344_1 ENSG00000171862 2 of 8 54 FFPE TGTTT G/A TTTGT CMDL140042 FLD0051 FLD0075 intron PTEN c.80-13C>T chr10 89653769 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653769", "IGV") medium 0.346 1413 pass no call 15572 PTEN_E00001156351_1 ENSG00000171862 1 of 8 2 FFPE CTTAA C/T TAAAG CMDL140042 FLD0051 FLD0075 nonsynonymous PTEN c.1049C>T p.T350I aCa/aTa chr10 89725066 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725066", "IGV") low 0.204 2897 QD no call 3770 PTEN_E00001456541_1 ENSG00000171862 9 of 9 tolerated(0.16) benign(0.297) 44 FFPE AAAAA C/T AGTAG CMDL140042 FLD0051 FLD0075 nonsynonymous PTEN c.1099C>T p.P367S Cca/Tca chr10 89725116 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725116", "IGV") medium 0.360 2897 pass no call 16445 PTEN_E00001456541_1 ENSG00000171862 9 of 9 tolerated(0.22) benign(0.043) 45 FFPE TAACA C/T CAGAT CMDL140042 FLD0051 FLD0075 nonsynonymous PTEN c.1076C>T p.A359V gCt/gTt chr10 89725093 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725093", "IGV") medium 0.130 1949 no call pass 4116 PTEN_E00001456541_2 ENSG00000171862 9 of 9 tolerated(0.22) benign(0.26) 5 FFPE AGAGG C/T TAGCA CMDL140042 FLD0051 FLD0075 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.012 1011 no call QD 884 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL140042 FLD0051 FLD0075 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.994 1011 no call QD 890 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140042 FLD0051 FLD0075 nonsynonymous TP53 c.541C>T p.R181C Cgc/Tgc chr17 7578389 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578389", "IGV") low 0.073 3132 no call QD 240 TP53_E00001255919_5 ENSG00000141510 5 of 11 rs587782596, CM920672, TP53_g.12529C>A, TP53_g.12529C>T, TP53_g.12529C>G, COSM11090, COSM45475, COSM131462, COSM131463, COSM131465, COSM3712584, COSM1638400, COSM131464 tolerated(0.14) benign(0.381) likely_pathogenic 11 FFPE GCAGC G/A CTCAT CMDL140042 FLD0051 FLD0075 nonsynonymous TP53 c.532C>T p.H178Y Cac/Tac chr17 7578398 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578398", "IGV") low 0.073 3132 no call QD 171 TP53_E00001255919_5 ENSG00000141510 5 of 11 CM111332, CD983489, TP53_g.12520C>T, TP53_g.12520C>G, TP53_g.12520C>A, TP53_g.12520del, COSM44120, COSM44659, COSM44901, COSM44068, COSM111498, COSM984946, COSM111495, COSM111496, COSM984950, COSM111497, COSM984949 deleterious(0) probably_damaging(1) 20 FFPE ATGGT G/A GGGGC CMDL140042 FLD0051 FLD0075 synonymous TP53 c.495G>A c.495G>A(p.%3D) caG/caA chr17 7578435 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578435", "IGV") low 0.122 2365 QD no call 527 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12483G>A, TP53_g.12483G>T, COSM4302127, COSM44558 57 FFPE TGTGA C/T TGCTT CMDL140042 FLD0051 FLD0075 intron TP53 c.74+52C>T chr17 7579787 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579787", "IGV") low 0.085 816 QD no call 292 TP53_E00001596491_1 ENSG00000141510 2 of 10 10 FFPE AGGGG G/A CTGGG CMDL140042 FLD0051 FLD0075 intron TP53 c.74+48C>T chr17 7579791 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579791", "IGV") low 0.272 968 no call QD 896 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs765863585 14 FFPE GGCTG G/A GGTTG CMDL140042 FLD0051 FLD0075 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.995 0.993 1630 971 pass pass 56207 36517 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140042 FLD0051 FLD0075 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") medium 0.409 1630 pass no call 11879 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL140042 FLD0051 FLD0075 splice_donor TP53 c.74+2T>C chr17 7579837 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7579837", "IGV") medium 0.332 971 no call pass 5136 TP53_E00001596491_1 ENSG00000141510 2 of 10 TP53_g.11081T>C 60 FFPE CACTC A/G CAGTT CMDL140042 FLD0051 FLD0075 nonsynonymous TP53 c.26G>A p.S9N aGc/aAc chr17 7579887 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579887", "IGV") low 0.149 971 no call QD 219 TP53_E00001596491_1 ENSG00000141510 2 of 11 tolerated(0.35) benign(0.015) 36 FFPE CGACG C/T TAGGA CMDL140042 FLD0051 FLD0075 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.993 0.995 419 546 pass pass 15259 17925 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140042 FLD0051 FLD0075 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.547 2796 pass no call 34085 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140042 FLD0051 FLD0075 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.208 2926 no call pass 5894 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140042 FLD0051 FLD0075 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") low 0.182 0.182 2796 2926 QD QD 4064 3846 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL140042 FLD0051 FLD0075 3_prime_UTR TP53 c.*21C>T chr17 7572906 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572906", "IGV") medium 0.321 2926 no call pass 16605 TP53_E00001757276_1 ENSG00000141510 11 of 11 37 FFPE CAGTG G/A GGAAC CMDL140042 FLD0051 FLD0075 3_prime_UTR TP53 c.*10C>T chr17 7572917 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572917", "IGV") low 0.188 2926 no call QD 4467 TP53_E00001757276_1 ENSG00000141510 11 of 11 48 FFPE AAGAA G/A TGGAG CMDL140042 FLD0051 FLD0075 splice_acceptor TP53 c.1101-2A>C chr17 7573010 T G =hyperlink("http://localhost:60151/goto?locus=chr17:7573010", "IGV") low 0.318 1377 QD no call 2291 TP53_E00001757276_1 ENSG00000141510 10 of 10 rs587781664, CS111031, TP53_g.17908A>G, TP53_g.17908A>T, TP53_g.17908A>C, COSM1191161, COSM12663, COSM45409, COSM1386548, COSM1679487 1 FFPE GTGGC T/G GTAGG CMDL140042 FLD0051 FLD0075 intron TP53 c.993+31G>A chr17 7576822 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576822", "IGV") low 0.097 2125 no call QD 1090 TP53_E00001789298_1 ENSG00000141510 9 of 10 16 FFPE ACTTT C/T CACTT CMDL140042 FLD0051 FLD0075 intron TP53 c.993+26A>G chr17 7576827 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7576827", "IGV") low 0.125 1855 QD no call 3593 TP53_E00001789298_1 ENSG00000141510 9 of 10 21 FFPE CCACT T/C GATAA CMDL140042 FLD0051 FLD0075 synonymous TP53 c.927C>T c.927C>T(p.%3D) ccC/ccT chr17 7576919 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576919", "IGV") low 0.143 4229 no call QD 118 TP53_E00001789298_1 ENSG00000141510 9 of 11 TP53_g.13999del, TP53_g.13999C>T, TP53_g.13999C>A, COSM249311, COSM43948, COSM249312 45 FFPE TTGTT G/A GGCAG CMDL140042 FLD0051 FLD0075 intron TP53 c.920-31C>T chr17 7576957 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576957", "IGV") low 0.129 2104 no call QD 3489 TP53_E00001789298_1 ENSG00000141510 8 of 10 7 FFPE TAAAA G/A TGAAT CMDL140042 FLD0051 FLD0075 nonsynonymous TP53 c.844C>T p.R282W Cgg/Tgg chr17 7577094 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577094", "IGV") low 0.138 3057 no call QD 69 TP53_E00001789298_3 25105660, 25404506, 22536362 ENSG00000141510 8 of 11 CM920678, CM056413, rs28934574, TP53_g.13824C>A, TP53_g.13824C>G, TP53_g.13824C>T, TP53_g.13824del, COSM43813, COSM10704, COSM10992, COSM44918, COSM99925, COSM99934, COSM3378339, COSM3675520, COSM1725698, COSM1636702 deleterious(0) probably_damaging(0.997) likely_benign,pathogenic 72 FFPE GCGCC G/A GTCTC CMDL140068 FLD0052 FLD0076 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.992 0.987 1611 1878 pass pass 68847 78650 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140068 FLD0052 FLD0076 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.993 0.994 1485 1702 pass pass 69602 77313 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140068 FLD0052 FLD0076 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.992 0.989 1450 1688 pass pass 61148 71111 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140068 FLD0052 FLD0076 intron TP53 c.97-34T>C chr17 7579624 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7579624", "IGV") low 0.078 107 no call QD 68 EXP0116_TP53_E3 ENSG00000141510 3 of 10 48 FFPE GGACC A/G GGTCC CMDL140068 FLD0052 FLD0076 intron TP53 c.97-45G>A chr17 7579635 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579635", "IGV") medium 0.298 336 pass no call 754 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE TCAGC C/T CCCCA CMDL140068 FLD0052 FLD0076 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") medium 0.200 0.165 336 107 QD pass 481 418 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL140068 FLD0052 FLD0076 intron TP53 c.97-54G>A chr17 7579644 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579644", "IGV") medium 0.310 0.220 336 107 QD pass 420 309 EXP0116_TP53_E3 ENSG00000141510 3 of 10 68 FFPE CAGCC C/T CCCAG CMDL140068 FLD0052 FLD0076 intron TP53 c.96+55G>A chr17 7579645 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579645", "IGV") medium 0.169 107 no call pass 428 EXP0116_TP53_E3 ENSG00000141510 3 of 10 69 FFPE AGCCC C/T CCAGC CMDL140068 FLD0052 FLD0076 intron TP53 c.96+53G>A chr17 7579647 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579647", "IGV") low 0.068 107 no call LowQual,QD 10 EXP0116_TP53_E3 ENSG00000141510 3 of 10 71 FFPE CCCCC C/T AGCCC CMDL140068 FLD0052 FLD0076 intron TP53 c.96+37G>A chr17 7579663 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579663", "IGV") medium 0.236 107 no call pass 629 EXP0116_TP53_E3 ENSG00000141510 3 of 10 72 FFPE GTCCC C/T AGCCC CMDL140068 FLD0052 FLD0076 intron TP53 c.96+24G>A chr17 7579676 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579676", "IGV") medium 0.260 107 no call pass 629 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE CAGGT C/T CCCAG CMDL140068 FLD0052 FLD0076 intron PTEN c.802-70A>T chr10 89720581 A T =hyperlink("http://localhost:60151/goto?locus=chr10:89720581", "IGV") high 0.494 0.506 1308 1318 pass pass 17079 17247 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs572978642 T:0.0006 101 FFPE TTTTT A/T AAAAA CMDL140068 FLD0052 FLD0076 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.011 89 no call QD 161 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL140068 FLD0052 FLD0076 nonsynonymous TP53 c.535C>T p.H179Y Cat/Tat chr17 7578395 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578395", "IGV") high 0.824 0.836 4008 4407 pass pass 84872 93425 TP53_E00001255919_5 ENSG00000141510 5 of 11 rs587780070, CM067054, TP53_g.12523C>G, TP53_g.12523C>T, TP53_g.12523C>A, TP53_g.12523del, COSM10768, COSM45520, COSM44776, COSM44151, COSM707884, COSM326728, COSM129848, COSM129849, COSM326727, COSM707885, COSM129851, COSM707887, COSM326729, COSM3388203, COSM3958834, COSM1709730, COSM2744838, COSM129850, COSM707886, COSM326730 deleterious(0) probably_damaging(1) pathogenic 17 FFPE CTCAT G/A GTGGG CMDL140068 FLD0052 FLD0076 splice_acceptor TP53 c.1101-2A>C chr17 7573010 T G =hyperlink("http://localhost:60151/goto?locus=chr17:7573010", "IGV") low 0.363 1302 QD no call 1688 TP53_E00001757276_1 ENSG00000141510 10 of 10 rs587781664, CS111031, TP53_g.17908A>G, TP53_g.17908A>T, TP53_g.17908A>C, COSM1191161, COSM12663, COSM45409, COSM1386548, COSM1679487 1 FFPE GTGGC T/G GTAGG CMDL140091 FLD0053 FLD0077 intron EGFR c.2284-57G>A chr7 55248929 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55248929", "IGV") medium 0.137 1501 no call pass 3667 EGFR_E00001601336_1 ENSG00000146648 19 of 27 9 FFPE CATGT G/A CCCCT CMDL140091 FLD0053 FLD0077 intron EGFR c.2284-56C>T chr7 55248930 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248930", "IGV") low 0.118 1501 no call QD 2620 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs41323247 T:0.0038 10 FFPE ATGTG C/T CCCTC CMDL140091 FLD0053 FLD0077 intron EGFR c.2284-54C>T chr7 55248932 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248932", "IGV") low 0.098 1279 QD no call 590 EGFR_E00001601336_1 ENSG00000146648 19 of 27 12 FFPE GTGCC C/T CTCCT CMDL140091 FLD0053 FLD0077 intron EGFR c.2284-33A>G chr7 55248953 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55248953", "IGV") low 0.087 1279 QD no call 371 EGFR_E00001601336_1 ENSG00000146648 19 of 27 33 FFPE ATGCG A/G AGCCA CMDL140091 FLD0053 FLD0077 intron EGFR c.2284-21C>T chr7 55248965 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248965", "IGV") low 0.146 2928 no call QD 1498 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs201251727 T:0.0012 45 FFPE ACTGA C/T GTGCC CMDL140091 FLD0053 FLD0077 intron EGFR c.2284-12C>T chr7 55248974 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248974", "IGV") low 0.185 2928 no call QD 4150 EGFR_E00001601336_1 ENSG00000146648 19 of 27 54 FFPE CCTCT C/T CCTCC CMDL140091 FLD0053 FLD0077 synonymous EGFR c.2301C>T c.2301C>T(p.%3D) gcC/gcT chr7 55249003 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249003", "IGV") low 0.186 2928 no call QD 4320 EGFR_E00001601336_1 ENSG00000146648 20 of 28 83 FFPE ATGGC C/T AGCGT CMDL140091 FLD0053 FLD0077 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.446 0.541 1244 1427 pass pass 18964 28351 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140091 FLD0053 FLD0077 stop_gained EGFR c.2371C>T p.Q791* Cag/Tag chr7 55249073 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249073", "IGV") medium 0.150 1427 no call pass 4378 EGFR_E00001601336_1 ENSG00000146648 20 of 28 20 FFPE TCACG C/T AGCTC CMDL140091 FLD0053 FLD0077 nonsynonymous EGFR c.2383T>C p.F795L Ttc/Ctc chr7 55249085 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55249085", "IGV") medium 0.187 1427 no call pass 6427 EGFR_E00001601336_1 ENSG00000146648 20 of 28 tolerated(0.17) benign(0.287) 8 FFPE TGCCC T/C TCGGC CMDL140091 FLD0053 FLD0077 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.478 0.502 1293 1563 pass pass 22603 28251 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140091 FLD0053 FLD0077 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.449 0.452 1380 1530 pass pass 21342 24062 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140091 FLD0053 FLD0077 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") low 0.145 422 QD no call 466 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL140091 FLD0053 FLD0077 nonsynonymous KRAS c.35G>T p.G12V gGt/gTt chr12 25398284 C A =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") low 0.166 0.172 3003 3708 QD QD 2111 3614 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) possibly_damaging(0.479) 26 FFPE CGCCA C/A CAGCT CMDL140091 FLD0053 FLD0077 nonsynonymous PIK3CA c.1634A>C p.E545A gAg/gCg chr3 178936092 A C =hyperlink("http://localhost:60151/goto?locus=chr3:178936092", "IGV") low 0.178 0.179 1218 1454 MQRankSum,QD MQRankSum,QD 1374 1052 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 rs121913274, COSM764, COSM12458, COSM27155, COSM125371, COSM297145 deleterious(0.02) probably_damaging(0.965) pathogenic 35 FFPE CACTG A/C GCAGG CMDL140091 FLD0053 FLD0077 splice_region,synonymous PTEN c.804C>T c.804C>T(p.%3D) gaC/gaT chr10 89720653 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720653", "IGV") low 0.200 71 no call pass 163 PTEN_E00001156315_1m ENSG00000171862 8 of 9 rs398123328 not_provided 32 FFPE TAGGA C/T AAAAT CMDL140091 FLD0053 FLD0077 splice_donor PTEN c.1026+1G>T chr10 89720876 G T =hyperlink("http://localhost:60151/goto?locus=chr10:89720876", "IGV") high 0.459 0.336 1769 2056 pass pass 27996 21686 PTEN_E00001156315_7 ENSG00000171862 8 of 8 rs398123313, CS110216, CS043794, COSM3441286, COSM5957, COSM5978, COSM19564 uncertain_significance 20 FFPE TTAAG G/T TCAGT CMDL140091 FLD0053 FLD0077 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.087 988 LowQual,QD no call 10 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL140091 FLD0053 FLD0077 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.991 0.996 1983 1960 pass pass 71328 66819 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140091 FLD0053 FLD0077 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") low 0.143 1960 no call QD 685 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL140091 FLD0053 FLD0077 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.993 0.995 1047 1280 pass pass 33538 39806 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140091 FLD0053 FLD0077 3_prime_UTR TP53 c.*41C>T chr17 7572886 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572886", "IGV") low 0.101 2700 no call QD 1279 TP53_E00001757276_1 ENSG00000141510 11 of 11 17 FFPE AGATG G/A GGGTG CMDL140091 FLD0053 FLD0077 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.148 2481 QD no call 3424 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140091 FLD0053 FLD0077 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.214 2700 no call pass 7526 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140129 FLD0054 FLD0078 nonsynonymous EGFR c.2314C>T p.P772S Ccc/Tcc chr7 55249016 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249016", "IGV") low 0.090 3010 no call QD 1664 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs746677478 deleterious(0) probably_damaging(0.95) 77 FFPE ACAAC C/T CCCAC CMDL140129 FLD0054 FLD0078 nonsynonymous EGFR c.2315C>T p.P772L cCc/cTc chr7 55249017 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249017", "IGV") low 0.090 3010 no call QD 1664 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM115794 deleterious(0) probably_damaging(0.986) 76 FFPE CAACC C/T CCACG CMDL140129 FLD0054 FLD0078 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") low 0.124 905 no call QD 73 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL140129 FLD0054 FLD0078 intron TP53 c.97-44G>A chr17 7579634 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579634", "IGV") low 0.066 606 QD no call 71 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs762445877 58 FFPE CTCAG C/T CCCCC CMDL140129 FLD0054 FLD0078 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") low 0.148 905 no call QD 535 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL140129 FLD0054 FLD0078 intron PTEN c.802-11T>C chr10 89720640 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720640", "IGV") low 0.012 75 QD no call 74 PTEN_E00001156315_1m ENSG00000171862 7 of 8 45 FFPE TTTTT T/C TTTTT CMDL140129 FLD0054 FLD0078 splice_region,intron PTEN c.802-8T>C chr10 89720643 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720643", "IGV") low 0.010 101 no call QD 46 PTEN_E00001156315_1m ENSG00000171862 7 of 8 42 FFPE TTTTT T/C TTTTT CMDL140129 FLD0054 FLD0078 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") high 0.986 0.993 870 1340 pass pass 31896 55534 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140129 FLD0054 FLD0078 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") low 0.129 812 no call QD 1456 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL140129 FLD0054 FLD0078 intron TP53 c.74+53C>T chr17 7579786 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579786", "IGV") low 0.090 723 QD no call 390 TP53_E00001596491_1 ENSG00000141510 2 of 10 9 FFPE TAGGG G/A GCTGG CMDL140129 FLD0054 FLD0078 intron TP53 c.74+52C>T chr17 7579787 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579787", "IGV") low 0.076 723 QD no call 35 TP53_E00001596491_1 ENSG00000141510 2 of 10 10 FFPE AGGGG G/A CTGGG CMDL140129 FLD0054 FLD0078 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.895 0.876 1444 1608 pass pass 41984 43837 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140129 FLD0054 FLD0078 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") low 0.133 1444 QD no call 668 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL140129 FLD0054 FLD0078 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.959 0.966 707 1051 pass pass 22177 31851 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140129 FLD0054 FLD0078 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.122 2892 no call QD 942 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140129 FLD0054 FLD0078 nonsynonymous TP53 c.824G>T p.C275F tGt/tTt chr17 7577114 C A =hyperlink("http://localhost:60151/goto?locus=chr17:7577114", "IGV") high 0.770 0.724 2126 3006 pass pass 42862 53909 TP53_E00001789298_3 ENSG00000141510 8 of 11 CM951234, CM076568, TP53_g.13804G>A, TP53_g.13804del, TP53_g.13804G>C, TP53_g.13804G>T, COSM10701, COSM10893, COSM45413, COSM44178, COSM165084, COSM99932, COSM1167915, COSM318164, COSM3403255, COSM3723938, COSM1637959, COSM2744531, COSM1728541 deleterious(0) probably_damaging(0.983) 53 FFPE AGGCA C/A AAACA CMDL140130 FLD0055 FLD0079 intron EGFR c.2284-56C>T chr7 55248930 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248930", "IGV") low 0.082 1392 no call QD 477 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs41323247 T:0.0038 10 FFPE ATGTG C/T CCCTC CMDL140130 FLD0055 FLD0079 intron EGFR c.2284-40C>T chr7 55248946 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248946", "IGV") low 0.075 1392 no call LowQual,QD 17 EGFR_E00001601336_1 ENSG00000146648 19 of 27 26 FFPE GGCCA C/T CATGC CMDL140130 FLD0055 FLD0079 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.485 0.514 1526 1345 pass pass 26269 25840 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140130 FLD0055 FLD0079 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.439 0.508 1472 1261 pass pass 21260 23140 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140130 FLD0055 FLD0079 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.476 0.561 1447 1593 pass pass 24377 32985 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140130 FLD0055 FLD0079 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") high 0.435 0.403 1303 1146 pass pass 10664 9656 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL140130 FLD0055 FLD0079 intron TP53 c.97-45G>A chr17 7579635 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579635", "IGV") low 0.128 1303 QD no call 1722 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE TCAGC C/T CCCCA CMDL140130 FLD0055 FLD0079 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") low 0.116 0.111 1303 1145 QD QD 375 947 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL140130 FLD0055 FLD0079 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") medium 0.113 1145 no call pass 2494 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL140130 FLD0055 FLD0079 intron PTEN c.802-14T>C chr10 89720637 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720637", "IGV") low 0.016 87 no call LowQual,QD 19 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs775342006 48 FFPE TCTTT T/C TTTTT CMDL140130 FLD0055 FLD0079 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.007 946 no call QD 72 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL140130 FLD0055 FLD0079 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.104 0.109 1083 1051 QD QD 710 810 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL140130 FLD0055 FLD0079 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.614 0.539 2164 2090 pass pass 33914 26440 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140130 FLD0055 FLD0079 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.798 0.791 1551 1133 pass pass 35106 25414 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140130 FLD0055 FLD0079 3_prime_UTR TP53 c.*51C>T chr17 7572876 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572876", "IGV") low 0.084 1468 no call QD 481 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs760698953 7 FFPE GGGGA G/A GGAGA CMDL140130 FLD0055 FLD0079 3_prime_UTR TP53 c.*36C>T chr17 7572891 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572891", "IGV") low 0.125 3024 no call QD 1335 TP53_E00001757276_1 ENSG00000141510 11 of 11 22 FFPE GGGGT G/A GGAGG CMDL140136 FLD0056 FLD0080 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.694 0.304 1346 1634 pass pass 35382 15355 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140136 FLD0056 FLD0080 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.499 0.513 1395 1652 pass pass 24833 31587 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140136 FLD0056 FLD0080 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 1.000 0.990 1380 1580 pass pass 59234 66579 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140136 FLD0056 FLD0080 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.503 0.493 3440 3858 pass pass 34048 34565 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL140136 FLD0056 FLD0080 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") medium 0.246 939 no call pass 5307 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL140136 FLD0056 FLD0080 intron PTEN c.802-11T>C chr10 89720640 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720640", "IGV") low 0.014 91 no call QD 120 PTEN_E00001156315_1m ENSG00000171862 7 of 8 45 FFPE TTTTT T/C TTTTT CMDL140136 FLD0056 FLD0080 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") medium 0.116 0.161 987 1031 QD pass 1209 3468 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL140136 FLD0056 FLD0080 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.995 0.992 1957 2052 pass pass 67846 75661 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140136 FLD0056 FLD0080 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") low 0.106 2052 no call QD 2355 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL140136 FLD0056 FLD0080 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.998 0.989 994 1039 pass pass 30835 31802 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140145 FLD0057 FLD0081 nonsynonymous BRAF c.1785T>G p.F595L ttT/ttG chr7 140453150 A C =hyperlink("http://localhost:60151/goto?locus=chr7:140453150", "IGV") high 0.274 0.252 3315 3815 pass pass 11184 9200 BRAF_AA_HS ENSG00000157764 15 of 18 CM080112, rs121913341, CM060882, COSM468, COSM1448595, COSM53198 deleterious(0.01) possibly_damaging(0.622) likely_pathogenic,pathogenic 24 FFPE AGACC A/C AAATC CMDL140145 FLD0057 FLD0081 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.561 0.489 1620 1693 pass pass 33113 28998 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140145 FLD0057 FLD0081 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.517 0.532 1448 1476 pass pass 27921 29463 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140145 FLD0057 FLD0081 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.994 0.998 1538 1623 pass pass 65359 69259 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140145 FLD0057 FLD0081 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.393 393 QD no call 660 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL140145 FLD0057 FLD0081 intron TP53 c.97-49G>A chr17 7579639 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579639", "IGV") low 0.258 393 QD no call 546 EXP0116_TP53_E3 ENSG00000141510 3 of 10 63 FFPE CCCCC C/T AGCCC CMDL140145 FLD0057 FLD0081 intron TP53 c.97-54G>A chr17 7579644 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579644", "IGV") low 0.261 393 QD no call 546 EXP0116_TP53_E3 ENSG00000141510 3 of 10 68 FFPE CAGCC C/T CCCAG CMDL140145 FLD0057 FLD0081 intron TP53 c.96+23G>A chr17 7579677 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579677", "IGV") low 0.389 393 QD no call 719 EXP0116_TP53_E3 ENSG00000141510 3 of 10 58 FFPE AGGTC C/T CCAGC CMDL140145 FLD0057 FLD0081 splice_region,synonymous TP53 c.96G>A c.96G>A(p.%3D) ctG/ctA chr17 7579700 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579700", "IGV") low 0.105 49 no call QD 34 EXP0116_TP53_E3 ENSG00000141510 3 of 11 35 FFPE CTTAC C/T AGAAC CMDL140145 FLD0057 FLD0081 nonsynonymous KRAS c.35G>A p.G12D gGt/gAt chr12 25398284 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") high 0.285 0.285 3150 3563 pass pass 10519 12031 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) benign(0.361) 26 FFPE CGCCA C/T CAGCT CMDL140145 FLD0057 FLD0081 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.015 76 QD no call 92 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL140145 FLD0057 FLD0081 stop_gained TP53 c.272G>A p.W91* tGg/tAg chr17 7579415 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579415", "IGV") high 0.308 0.269 728 843 pass pass 3475 3191 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11503G>A, COSM44192, COSM323934, COSM323933, COSM3378448, COSM3378447 38 FFPE GGGGC C/T AGGAG CMDL140159 FLD0058 FLD0082 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.987 0.987 1783 1682 pass pass 76605 72187 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140159 FLD0058 FLD0082 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.989 0.993 1588 1470 pass pass 72583 67824 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140159 FLD0058 FLD0082 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.997 0.998 1546 1585 pass pass 65844 67832 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140159 FLD0058 FLD0082 nonsynonymous KRAS c.35G>T p.G12V gGt/gTt chr12 25398284 C A =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") high 0.381 0.368 3503 3751 pass pass 21661 22030 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) possibly_damaging(0.479) 26 FFPE CGCCA C/A CAGCT CMDL140159 FLD0058 FLD0082 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.020 118 no call QD 116 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL140159 FLD0058 FLD0082 nonsynonymous PTEN c.52G>A p.E18K Gag/Aag chr10 89624278 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624278", "IGV") low 1.000 2 no call LowQual 22 PTEN_E00001456562_1 ENSG00000171862 1 of 9 tolerated(0.14) benign(0.007) 75 FFPE ATCAA G/A AGGAT CMDL140159 FLD0058 FLD0082 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.987 1340 no call pass 54594 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140159 FLD0058 FLD0082 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.993 0.987 2212 2007 pass pass 76523 63298 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140159 FLD0058 FLD0082 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.992 0.994 1422 1377 pass pass 43066 40729 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140162 FLD0059 FLD0083 nonsynonymous EGFR c.2300C>T p.A767V gCc/gTc chr7 55249002 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249002", "IGV") medium 0.299 2736 no call pass 13596 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs397517107, COSM26445 deleterious(0) probably_damaging(1) uncertain_significance 82 FFPE GATGG C/T CAGCG CMDL140162 FLD0059 FLD0083 synonymous EGFR c.2310C>T c.2310C>T(p.%3D) gaC/gaT chr7 55249012 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249012", "IGV") medium 0.300 2736 no call pass 27183 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs397517110 likely_benign 81 FFPE GTGGA C/T AACCC CMDL140162 FLD0059 FLD0083 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.987 0.987 1243 1556 pass pass 52034 64836 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140162 FLD0059 FLD0083 synonymous EGFR c.2349C>T c.2349C>T(p.%3D) acC/acT chr7 55249051 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249051", "IGV") low 0.087 1643 no call QD 779 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs397517122 likely_benign 30 FFPE CTCAC C/T TCCAC CMDL140162 FLD0059 FLD0083 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.989 0.990 1537 1715 pass pass 71487 83084 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140162 FLD0059 FLD0083 splice_donor EGFR c.2701+1G>A chr7 55260535 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260535", "IGV") low 0.107 2053 no call QD 1907 EGFR_E00001631695_1 ENSG00000146648 22 of 27 18 FFPE CTACG G/A TGAGT CMDL140162 FLD0059 FLD0083 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.997 0.994 1571 1483 pass pass 67558 64484 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140162 FLD0059 FLD0083 intron TP53 c.97-19T>C chr17 7579609 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7579609", "IGV") medium 0.467 530 no call pass 5586 EXP0116_TP53_E3 ENSG00000141510 3 of 10 33 FFPE AAAAG A/G GCAGT CMDL140162 FLD0059 FLD0083 intron TP53 c.97-25G>A chr17 7579615 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579615", "IGV") medium 0.235 178 pass no call 1284 EXP0116_TP53_E3 ENSG00000141510 3 of 10 39 FFPE GCAGT C/T AGAGG CMDL140162 FLD0059 FLD0083 intron TP53 c.97-41G>A chr17 7579631 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579631", "IGV") medium 0.236 178 pass no call 1284 EXP0116_TP53_E3 ENSG00000141510 3 of 10 55 FFPE GTCCT C/T AGCCC CMDL140162 FLD0059 FLD0083 intron TP53 c.97-48G>A chr17 7579638 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579638", "IGV") medium 0.647 530 no call pass 12777 EXP0116_TP53_E3 ENSG00000141510 3 of 10 62 FFPE GCCCC C/T CAGCC CMDL140162 FLD0059 FLD0083 synonymous PIK3CA c.1581C>T c.1581C>T(p.%3D) gaC/gaT chr3 178936039 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178936039", "IGV") low 0.144 2074 QD no call 650 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 75 FFPE AATGA C/T AAAGA CMDL140162 FLD0059 FLD0083 intron PTEN c.802-130G>A chr10 89720521 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720521", "IGV") low 0.072 1064 QD no call 126 PTEN_E00001156315_1m ENSG00000171862 7 of 8 41 FFPE CAAAT G/A ATAGT CMDL140162 FLD0059 FLD0083 intron PTEN c.802-11T>C chr10 89720640 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720640", "IGV") medium 0.041 162 no call pass 1091 PTEN_E00001156315_1m ENSG00000171862 7 of 8 45 FFPE TTTTT T/C TTTTT CMDL140162 FLD0059 FLD0083 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.002 1115 no call LowQual,QD 23 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL140162 FLD0059 FLD0083 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.992 1115 no call LowQual,QD 23 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140162 FLD0059 FLD0083 intron TP53 c.74+53C>T chr17 7579786 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579786", "IGV") medium 0.304 1146 pass no call 10375 TP53_E00001596491_1 ENSG00000141510 2 of 10 9 FFPE TAGGG G/A GCTGG CMDL140162 FLD0059 FLD0083 intron TP53 c.74+52C>T chr17 7579787 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579787", "IGV") low 0.090 985 no call QD 471 TP53_E00001596491_1 ENSG00000141510 2 of 10 10 FFPE AGGGG G/A CTGGG CMDL140162 FLD0059 FLD0083 intron TP53 c.74+49C>T chr17 7579790 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579790", "IGV") low 0.151 1005 no call QD 1821 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs762400295 13 FFPE GGGCT G/A GGGTT CMDL140162 FLD0059 FLD0083 intron TP53 c.74+43C>T chr17 7579796 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579796", "IGV") low 0.188 2314 QD no call 3541 TP53_E00001596491_1 ENSG00000141510 2 of 10 19 FFPE GGGTT G/A GGGTG CMDL140162 FLD0059 FLD0083 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.997 0.996 2314 1958 pass pass 80312 73181 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140162 FLD0059 FLD0083 intron TP53 c.74+35C>T chr17 7579804 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579804", "IGV") low 0.136 1958 no call QD 291 TP53_E00001596491_1 ENSG00000141510 2 of 10 27 FFPE GTGGG G/A GTGGT CMDL140162 FLD0059 FLD0083 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.976 0.987 571 728 pass pass 18768 25583 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140162 FLD0059 FLD0083 3_prime_UTR TP53 c.*50C>T chr17 7572877 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572877", "IGV") low 0.085 1503 no call QD 1198 TP53_E00001757276_1 ENSG00000141510 11 of 11 8 FFPE GGGAG G/A GAGAG CMDL140162 FLD0059 FLD0083 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.177 2333 QD no call 4016 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140162 FLD0059 FLD0083 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") low 0.140 2333 QD no call 1344 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL140162 FLD0059 FLD0083 3_prime_UTR TP53 c.*20C>T chr17 7572907 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572907", "IGV") medium 0.172 2878 no call pass 7937 TP53_E00001757276_1 ENSG00000141510 11 of 11 38 FFPE AGTGG G/A GAACA CMDL140162 FLD0059 FLD0083 nonsynonymous TP53 c.1168C>T p.P390S Cct/Tct chr17 7572941 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572941", "IGV") low 0.124 2333 QD no call 435 TP53_E00001757276_1 ENSG00000141510 11 of 11 tolerated(0.39) possibly_damaging(0.662) 70 FFPE GTCAG G/A CCCTT CMDL140162 FLD0059 FLD0083 nonsynonymous TP53 c.1160C>T p.T387I aCa/aTa chr17 7572949 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572949", "IGV") low 0.205 2333 QD no call 2931 TP53_E00001757276_1 ENSG00000141510 11 of 11 tolerated(0.07) benign(0.081) 62 FFPE CTTCT G/A TCTTG CMDL140162 FLD0059 FLD0083 nonsynonymous TP53 c.1147C>T p.L383F Ctc/Ttc chr17 7572962 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572962", "IGV") low 0.157 2333 QD no call 2003 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs150842067, COSM307349 deleterious(0.02) benign(0.361) 49 FFPE CATGA G/A TTTTT CMDL140175 FLD0060 FLD0084 nonsynonymous BRAF c.1799T>A p.V600E gTg/gAg chr7 140453136 A T =hyperlink("http://localhost:60151/goto?locus=chr7:140453136", "IGV") high 0.533 0.568 3745 4151 pass pass 41253 49040 BRAF_AA_HS ENSG00000157764 15 of 18 CM112509, COSM476, COSM6137, COSM18443 deleterious(0) probably_damaging(0.967) 10 FFPE ATTTC A/T CTGTA CMDL140175 FLD0060 FLD0084 intron EGFR c.2284-54C>T chr7 55248932 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248932", "IGV") low 0.077 1241 no call QD 1285 EGFR_E00001601336_1 ENSG00000146648 19 of 27 12 FFPE GTGCC C/T CTCCT CMDL140175 FLD0060 FLD0084 intron EGFR c.2284-14C>T chr7 55248972 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248972", "IGV") low 0.091 2857 no call QD 471 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs776154077 52 FFPE TGCCT C/T TCCCT CMDL140175 FLD0060 FLD0084 splice_region,intron EGFR c.2284-4C>T chr7 55248982 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248982", "IGV") low 0.090 2857 no call QD 393 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs766533982 62 FFPE TCCCT C/T CAGGA CMDL140175 FLD0060 FLD0084 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.575 0.663 1501 1616 pass pass 32520 41735 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140175 FLD0060 FLD0084 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.632 0.631 1481 1746 pass pass 37436 40294 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140175 FLD0060 FLD0084 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.996 0.976 1615 1696 pass pass 69254 70611 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140175 FLD0060 FLD0084 synonymous EGFR c.3099C>T c.3099C>T(p.%3D) ccC/ccT chr7 55269033 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269033", "IGV") high 0.578 0.586 3358 3843 pass pass 43903 50199 EGFR_E00001801208_2 ENSG00000146648 25 of 28 rs370198879 46 FFPE ACTCC C/T CTCCT CMDL140175 FLD0060 FLD0084 intron TP53 c.97-44G>A chr17 7579634 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579634", "IGV") medium 0.209 374 pass no call 1011 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs762445877 58 FFPE CTCAG C/T CCCCC CMDL140175 FLD0060 FLD0084 intron TP53 c.96+21G>A chr17 7579679 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579679", "IGV") medium 0.705 751 no call pass 13461 EXP0116_TP53_E3 ENSG00000141510 3 of 10 56 FFPE GTCCC C/T AGCCC CMDL140175 FLD0060 FLD0084 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.026 0.022 103 165 QD QD 185 154 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL140175 FLD0060 FLD0084 intron PTEN c.802-11T>C chr10 89720640 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720640", "IGV") low 0.024 165 no call QD 238 PTEN_E00001156315_1m ENSG00000171862 7 of 8 45 FFPE TTTTT T/C TTTTT CMDL140175 FLD0060 FLD0084 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.475 1492 no call pass 24576 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140175 FLD0060 FLD0084 intron TP53 c.74+56C>T chr17 7579783 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579783", "IGV") medium 0.125 1182 pass no call 2818 TP53_E00001596491_1 ENSG00000141510 2 of 10 6 FFPE TGCTA G/A GGGGC CMDL140175 FLD0060 FLD0084 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") medium 0.093 0.167 1183 1298 QD pass 900 5017 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL140175 FLD0060 FLD0084 intron TP53 c.74+46C>T chr17 7579793 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579793", "IGV") low 0.089 2594 no call QD 498 TP53_E00001596491_1 ENSG00000141510 2 of 10 16 FFPE CTGGG G/A TTGGG CMDL140175 FLD0060 FLD0084 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.644 0.585 2371 2594 pass pass 42221 44396 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140175 FLD0060 FLD0084 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") low 0.102 2594 no call QD 1462 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL140175 FLD0060 FLD0084 5_prime_UTR TP53 c.-2C>T chr17 7579914 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579914", "IGV") low 0.119 1321 no call QD 2307 TP53_E00001596491_1 ENSG00000141510 2 of 11 9 FFPE CCATG G/A CAGTG CMDL140175 FLD0060 FLD0084 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.833 0.856 679 796 pass pass 14292 19589 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140175 FLD0060 FLD0084 3_prime_UTR TP53 c.*41C>T chr17 7572886 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572886", "IGV") medium 0.327 2942 no call pass 16285 TP53_E00001757276_1 ENSG00000141510 11 of 11 17 FFPE AGATG G/A GGGTG CMDL140175 FLD0060 FLD0084 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.198 0.186 2408 2942 pass QD 6171 4301 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140175 FLD0060 FLD0084 3_prime_UTR TP53 c.*36C>T chr17 7572891 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572891", "IGV") low 0.140 2408 QD no call 869 TP53_E00001757276_1 ENSG00000141510 11 of 11 22 FFPE GGGGT G/A GGAGG CMDL140175 FLD0060 FLD0084 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") low 0.216 2408 QD no call 4445 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL140184 FLD0061 FLD0085 intron EGFR c.2284-31G>A chr7 55248955 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55248955", "IGV") medium 0.306 1597 no call pass 14743 EGFR_E00001601336_1 ENSG00000146648 19 of 27 35 FFPE GCGAA G/A CCACA CMDL140184 FLD0061 FLD0085 splice_region,intron EGFR c.2284-4C>T chr7 55248982 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248982", "IGV") high 0.938 0.370 125 3126 pass pass 3045 17585 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs766533982 62 FFPE TCCCT C/T CAGGA CMDL140184 FLD0061 FLD0085 synonymous EGFR c.2325C>T c.2325C>T(p.%3D) tgC/tgT chr7 55249027 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249027", "IGV") medium 0.923 125 pass no call 2879 EGFR_E00001601336_1 ENSG00000146648 20 of 28 66 FFPE GTGTG C/T CGCCT CMDL140184 FLD0061 FLD0085 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") medium 0.877 0.986 61 1535 pass pass 1991 64060 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140184 FLD0061 FLD0085 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.995 0.995 1246 1617 pass pass 65475 75192 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140184 FLD0061 FLD0085 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.986 0.994 1256 1725 pass pass 54454 74010 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140184 FLD0061 FLD0085 intron TP53 c.97-25G>A chr17 7579615 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579615", "IGV") medium 0.306 1224 no call pass 7091 EXP0116_TP53_E3 ENSG00000141510 3 of 10 39 FFPE GCAGT C/T AGAGG CMDL140184 FLD0061 FLD0085 intron TP53 c.97-27C>T chr17 7579617 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579617", "IGV") low 0.239 71 pass no call 350 EXP0116_TP53_E3 ENSG00000141510 3 of 10 41 FFPE AGTCA G/A AGGAC CMDL140184 FLD0061 FLD0085 intron TP53 c.97-44G>A chr17 7579634 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579634", "IGV") medium 0.329 1224 no call pass 8226 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs762445877 58 FFPE CTCAG C/T CCCCC CMDL140184 FLD0061 FLD0085 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") medium 0.176 1224 no call pass 2936 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL140184 FLD0061 FLD0085 intron TP53 c.96+11G>A chr17 7579689 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579689", "IGV") low 0.180 71 QD no call 81 EXP0116_TP53_E3 ENSG00000141510 3 of 10 46 FFPE CAACC C/T TTGTC CMDL140184 FLD0061 FLD0085 splice_region,intron TP53 c.75-6T>A chr17 7579727 A T =hyperlink("http://localhost:60151/goto?locus=chr17:7579727", "IGV") low 0.232 43 pass no call 220 EXP0116_TP53_E3 ENSG00000141510 2 of 10 8 FFPE CTGAA A/T GACAA CMDL140184 FLD0061 FLD0085 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.025 1050 no call QD 1848 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL140184 FLD0061 FLD0085 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.998 1050 no call QD 1848 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140184 FLD0061 FLD0085 nonsynonymous TP53 c.472C>T p.R158C Cgc/Tgc chr17 7578458 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578458", "IGV") low 0.145 3767 no call QD 6118 TP53_E00001255919_5 ENSG00000141510 5 of 11 rs587780068, CM004341, TP53_g.12460del, TP53_g.12460C>G, TP53_g.12460C>T, TP53_g.12460C>A, COSM43848, COSM43781, COSM11087, COSM3970361, COSM318152, COSM984954, COSM3970360, COSM984956, COSM3970364, COSM318151, COSM984958, COSM3970366, COSM318153, COSM3970359, COSM3970363, COSM3932746, COSM3970362, COSM2744899, COSM1750371, COSM984957, COSM318154, COSM3970365 deleterious(0) probably_damaging(0.996) 51 FFPE GGCGC G/A GACGC CMDL140184 FLD0061 FLD0085 intron TP53 c.74+56C>T chr17 7579783 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579783", "IGV") medium 0.183 817 no call pass 4220 TP53_E00001596491_1 ENSG00000141510 2 of 10 6 FFPE TGCTA G/A GGGGC CMDL140184 FLD0061 FLD0085 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") medium 0.398 996 pass no call 14530 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL140184 FLD0061 FLD0085 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.994 0.994 2022 1647 pass pass 73433 64312 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140184 FLD0061 FLD0085 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") low 0.177 1647 no call QD 1891 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL140184 FLD0061 FLD0085 intron TP53 c.74+36C>T chr17 7579803 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579803", "IGV") low 0.131 1647 no call QD 326 TP53_E00001596491_1 ENSG00000141510 2 of 10 26 FFPE GGTGG G/A GGTGG CMDL140184 FLD0061 FLD0085 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") medium 0.178 1647 no call pass 3289 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL140184 FLD0061 FLD0085 intron TP53 c.74+31C>T chr17 7579808 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579808", "IGV") medium 0.367 2022 pass no call 14237 TP53_E00001596491_1 ENSG00000141510 2 of 10 31 FFPE GGGTG G/A TGGGC CMDL140184 FLD0061 FLD0085 nonsynonymous TP53 c.284C>T p.S95F tCt/tTt chr17 7579403 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579403", "IGV") low 0.074 390 QD no call 137 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11515C>T, COSM44673 deleterious(0.01) possibly_damaging(0.589) 26 FFPE CAGAA G/A ATGAC CMDL140184 FLD0061 FLD0085 nonsynonymous TP53 c.275C>T p.P92L cCc/cTc chr17 7579412 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579412", "IGV") low 0.129 390 QD no call 666 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11506C>T, COSM45972 deleterious(0.03) possibly_damaging(0.625) 35 FFPE ACAGG G/A GCCAG CMDL140184 FLD0061 FLD0085 synonymous TP53 c.264C>T c.264C>T(p.%3D) gcC/gcT chr17 7579423 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579423", "IGV") low 0.101 390 QD no call 282 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11495C>T 46 FFPE GAGGG G/A GCTGG CMDL140184 FLD0061 FLD0085 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.988 1.000 390 508 pass pass 14663 18854 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140184 FLD0061 FLD0085 3_prime_UTR TP53 c.*51C>T chr17 7572876 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572876", "IGV") medium 0.294 1229 no call pass 6901 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs760698953 7 FFPE GGGGA G/A GGAGA CMDL140184 FLD0061 FLD0085 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.118 2732 no call QD 3213 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140184 FLD0061 FLD0085 3_prime_UTR TP53 c.*39C>A chr17 7572888 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.114 1809 QD no call 884 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/T GTGGG CMDL140184 FLD0061 FLD0085 3_prime_UTR TP53 c.*34C>T chr17 7572893 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572893", "IGV") low 0.106 2732 no call QD 368 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs545818827 A:0.0002 24 FFPE GGTGG G/A AGGCT CMDL140184 FLD0061 FLD0085 3_prime_UTR TP53 c.*21C>T chr17 7572906 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572906", "IGV") low 0.149 0.097 1809 2732 QD QD 880 556 TP53_E00001757276_1 ENSG00000141510 11 of 11 37 FFPE CAGTG G/A GGAAC CMDL140184 FLD0061 FLD0085 3_prime_UTR TP53 c.*20C>T chr17 7572907 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572907", "IGV") low 0.108 2732 no call QD 4261 TP53_E00001757276_1 ENSG00000141510 11 of 11 38 FFPE AGTGG G/A GAACA CMDL140184 FLD0061 FLD0085 3_prime_UTR TP53 c.*5C>T chr17 7572922 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572922", "IGV") low 0.181 1809 QD no call 1665 TP53_E00001757276_1 ENSG00000141510 11 of 11 53 FFPE GTGGA G/A AATGT CMDL140187 FLD0062 FLD0086 intron EGFR c.2284-50C>T chr7 55248936 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248936", "IGV") low 0.102 1643 no call QD 1761 EGFR_E00001601336_1 ENSG00000146648 19 of 27 16 FFPE CCCTC C/T TTCTG CMDL140187 FLD0062 FLD0086 synonymous EGFR c.2307G>A c.2307G>A(p.%3D) gtG/gtA chr7 55249009 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249009", "IGV") medium 0.225 3039 pass no call 6361 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs757699292, COSM1451596 84 FFPE AGCGT G/A GACAA CMDL140187 FLD0062 FLD0086 nonsynonymous EGFR c.2315C>T p.P772L cCc/cTc chr7 55249017 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249017", "IGV") low 0.113 3212 no call QD 5894 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM115794 deleterious(0) probably_damaging(0.986) 76 FFPE CAACC C/T CCACG CMDL140187 FLD0062 FLD0086 nonsynonymous EGFR c.2317C>T p.H773Y Cac/Tac chr7 55249019 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249019", "IGV") medium 0.118 3212 no call pass 6490 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs767075090 tolerated(0.54) benign(0.102) 74 FFPE ACCCC C/T ACGTG CMDL140187 FLD0062 FLD0086 nonsynonymous EGFR c.2335G>A p.G779S Ggc/Agc chr7 55249037 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249037", "IGV") low 0.206 3039 QD no call 4529 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs397517119, COSM22942, COSM25016 deleterious(0.03) probably_damaging(1) uncertain_significance 56 FFPE TGCTG G/A GCATC CMDL140187 FLD0062 FLD0086 nonsynonymous EGFR c.2354C>T p.T785I aCc/aTc chr7 55249056 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249056", "IGV") medium 0.131 1575 no call pass 3190 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM53288, COSM28930 deleterious(0) probably_damaging(1) 37 FFPE CTCCA C/T CGTGC CMDL140187 FLD0062 FLD0086 nonsynonymous EGFR c.2384T>C p.F795S tTc/tCc chr7 55249086 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55249086", "IGV") low 0.091 1569 no call QD 154 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM22951 deleterious(0.01) possibly_damaging(0.86) 7 FFPE GCCCT T/C CGGCT CMDL140187 FLD0062 FLD0086 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.993 0.998 1642 1551 pass pass 70271 66464 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140187 FLD0062 FLD0086 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") medium 0.730 588 no call pass 9627 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL140187 FLD0062 FLD0086 splice_region,synonymous TP53 c.96G>A c.96G>A(p.%3D) ctG/ctA chr17 7579700 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579700", "IGV") medium 0.460 512 pass no call 8111 EXP0116_TP53_E3 ENSG00000141510 3 of 11 35 FFPE CTTAC C/T AGAAC CMDL140187 FLD0062 FLD0086 nonsynonymous PIK3CA c.1637A>C p.Q546P cAg/cCg chr3 178936095 A C =hyperlink("http://localhost:60151/goto?locus=chr3:178936095", "IGV") high 0.544 0.531 570 768 pass pass 11547 15260 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 rs397517201, COSM767, COSM25041, COSM12459, COSM446012, COSM1041496, COSM1757082 deleterious(0.01) probably_damaging(0.993) pathogenic 32 FFPE TGAGC A/C GGAGA CMDL140187 FLD0062 FLD0086 stop_gained PTEN c.821G>A p.W274* tGg/tAg chr10 89720670 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720670", "IGV") low 0.186 101 no call QD 176 PTEN_E00001156315_1m ENSG00000171862 8 of 9 CM1010008, COSM5162, COSM1349593, COSM23567 15 FFPE CTTTT G/A GGTAA CMDL140187 FLD0062 FLD0086 nonsynonymous PTEN c.352C>T p.H118Y Cat/Tat chr10 89692868 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692868", "IGV") medium 0.144 1412 no call pass 3520 PTEN_E00001156330_3 ENSG00000171862 5 of 9 deleterious(0) benign(0.309) 5 FFPE ACAAT C/T ATGTT CMDL140187 FLD0062 FLD0086 nonsynonymous PTEN c.69A>C p.L23F ttA/ttC chr10 89624295 A C =hyperlink("http://localhost:60151/goto?locus=chr10:89624295", "IGV") low 0.333 5 pass no call 47 PTEN_E00001456562_1 ENSG00000171862 1 of 9 CD043799, COSM5185 deleterious(0) probably_damaging(0.991) 58 FFPE GACTT A/C GACTT CMDL140187 FLD0062 FLD0086 nonsynonymous PTEN c.76A>G p.T26A Acc/Gcc chr10 89624302 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89624302", "IGV") low 0.333 5 pass no call 47 PTEN_E00001456562_1 ENSG00000171862 1 of 9 CM110133, COSM1561216, COSM5256 tolerated(0.13) benign(0.021) 51 FFPE ACTTG A/G CCTGT CMDL140187 FLD0062 FLD0086 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") high 0.289 0.242 877 999 pass pass 9127 6538 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL140187 FLD0062 FLD0086 intron TP53 c.74+49C>T chr17 7579790 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579790", "IGV") medium 0.293 888 pass no call 13811 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs762400295 13 FFPE GGGCT G/A GGGTT CMDL140187 FLD0062 FLD0086 intron TP53 c.74+46C>T chr17 7579793 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579793", "IGV") medium 0.241 1960 no call pass 6266 TP53_E00001596491_1 ENSG00000141510 2 of 10 16 FFPE CTGGG G/A TTGGG CMDL140187 FLD0062 FLD0086 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.662 0.454 1722 1960 pass pass 37049 23450 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140187 FLD0062 FLD0086 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") medium 0.288 1722 pass no call 13263 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL140187 FLD0062 FLD0086 nonsynonymous TP53 c.37C>T p.P13S Cct/Tct chr17 7579876 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579876", "IGV") medium 0.251 1722 pass no call 5026 TP53_E00001596491_1 ENSG00000141510 2 of 11 deleterious(0.05) possibly_damaging(0.687) 47 FFPE CAGAG G/A GGGCT CMDL140187 FLD0062 FLD0086 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.867 0.768 737 736 pass pass 18213 14567 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140187 FLD0062 FLD0086 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.165 0.133 2795 2245 QD QD 4077 650 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140187 FLD0062 FLD0086 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") low 0.140 2245 no call QD 1290 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL140193 FLD0063 FLD0087 splice_acceptor EGFR c.2284-1G>A chr7 55248985 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55248985", "IGV") medium 0.984 2374 no call pass 68777 EGFR_E00001601336_1 ENSG00000146648 19 of 27 65 FFPE CTCCA G/A GAAGC CMDL140193 FLD0063 FLD0087 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") medium 0.991 1157 no call pass 48983 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140193 FLD0063 FLD0087 synonymous EGFR c.2343C>T c.2343C>T(p.%3D) tgC/tgT chr7 55249045 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249045", "IGV") medium 0.166 1471 pass no call 5126 EGFR_E00001601336_2 ENSG00000146648 20 of 28 24 FFPE ATCTG C/T CTCAC CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.2348C>T p.T783I aCc/aTc chr7 55249050 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249050", "IGV") medium 0.129 1472 pass no call 3010 EGFR_E00001601336_2 ENSG00000146648 20 of 28 COSM14069 deleterious(0) probably_damaging(0.999) 29 FFPE CCTCA C/T CTCCA CMDL140193 FLD0063 FLD0087 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.990 0.994 1516 1449 pass pass 79860 91427 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140193 FLD0063 FLD0087 synonymous EGFR c.2388C>T c.2388C>T(p.%3D) ggC/ggT chr7 55249090 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249090", "IGV") low 0.180 2618 no call QD 2463 EGFR_E00001601336_2 ENSG00000146648 20 of 28 69 FFPE TTCGG C/T TGCCT CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.2408G>A p.R803Q cGg/cAg chr7 55249110 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249110", "IGV") low 0.144 2618 no call QD 472 EGFR_E00001601336_2 ENSG00000146648 20 of 28 deleterious(0.01) probably_damaging(0.999) 85 FFPE TGTCC G/A GGAAC CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.2411A>G p.E804G gAa/gGa chr7 55249113 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55249113", "IGV") low 0.111 2892 QD no call 1593 EGFR_E00001601336_2 ENSG00000146648 20 of 28 COSM20892 deleterious(0) probably_damaging(0.958) 82 FFPE CCGGG A/G ACACA CMDL140193 FLD0063 FLD0087 synonymous EGFR c.2433C>T c.2433C>T(p.%3D) tcC/tcT chr7 55249135 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249135", "IGV") medium 0.233 2618 no call pass 6277 EGFR_E00001601336_2 ENSG00000146648 20 of 28 60 FFPE GGCTC C/T CAGTA CMDL140193 FLD0063 FLD0087 splice_donor EGFR c.2469+1G>A chr7 55249172 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249172", "IGV") low 0.119 1260 no call QD 1815 EGFR_E00001601336_2 ENSG00000146648 20 of 27 23 FFPE CAAAG G/A TAATC CMDL140193 FLD0063 FLD0087 intron EGFR c.2626-61A>G chr7 55260398 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55260398", "IGV") medium 0.150 1673 no call pass 4832 EGFR_E00001631695_1 ENSG00000146648 21 of 27 11 FFPE AGTTA A/G CTTTT CMDL140193 FLD0063 FLD0087 intron EGFR c.2626-59T>C chr7 55260400 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55260400", "IGV") low 0.100 1673 no call QD 1695 EGFR_E00001631695_1 ENSG00000146648 21 of 27 13 FFPE TTAAC T/C TTTTC CMDL140193 FLD0063 FLD0087 intron EGFR c.2626-29C>T chr7 55260430 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260430", "IGV") low 0.184 3755 QD no call 4569 EGFR_E00001631695_1 ENSG00000146648 21 of 27 43 FFPE GTTGT C/T TCACT CMDL140193 FLD0063 FLD0087 intron EGFR c.2626-19C>T chr7 55260440 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260440", "IGV") medium 0.406 3365 no call pass 23615 EGFR_E00001631695_1 ENSG00000146648 21 of 27 rs17337360 T:0.0278 53 FFPE TGCCT C/T ATCTC CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.2675C>T p.T892I aCc/aTc chr7 55260508 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260508", "IGV") medium 0.406 3365 no call pass 23436 EGFR_E00001631695_1 ENSG00000146648 22 of 28 rs151064287 deleterious(0.02) probably_damaging(1) 45 FFPE CTATA C/T CCACC CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.2696G>A p.S899N aGc/aAc chr7 55260529 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260529", "IGV") medium 0.434 1865 pass no call 28944 EGFR_E00001631695_1 ENSG00000146648 22 of 28 deleterious(0.04) probably_damaging(0.999) 24 FFPE CTGGA G/A CTACG CMDL140193 FLD0063 FLD0087 splice_region,intron EGFR c.2701+5G>A chr7 55260539 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260539", "IGV") medium 0.436 1865 pass no call 29204 EGFR_E00001631695_1 ENSG00000146648 22 of 27 14 FFPE GGTGA G/A TCATA CMDL140193 FLD0063 FLD0087 intron EGFR c.2470-27C>T chr7 55259385 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259385", "IGV") medium 0.272 1482 no call pass 11109 EGFR_E00001681524_1 ENSG00000146648 20 of 27 14 FFPE TGTCC C/T TCACA CMDL140193 FLD0063 FLD0087 nonsynonymous,splice_region EGFR c.2471G>A p.G824D gGc/gAc chr7 55259413 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259413", "IGV") medium 0.255 3158 pass no call 8876 EGFR_E00001681524_1 24712396 ENSG00000146648 21 of 28 rs483352808 deleterious(0.03) probably_damaging(0.996) drug_response 42 FFPE TCAGG G/A CATGA CMDL140193 FLD0063 FLD0087 synonymous EGFR c.2481C>T c.2481C>T(p.%3D) taC/taT chr7 55259423 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259423", "IGV") low 0.151 3158 QD no call 254 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM53235, COSM1090890 52 FFPE AACTA C/T TTGGA CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.2525A>G p.N842S aAc/aGc chr7 55259467 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55259467", "IGV") low 0.138 2826 no call QD 600 EGFR_E00001681524_1 ENSG00000146648 21 of 28 deleterious(0) probably_damaging(0.973) 59 FFPE CAGGA A/G CGTAC CMDL140193 FLD0063 FLD0087 synonymous EGFR c.2526C>T c.2526C>T(p.%3D) aaC/aaT chr7 55259468 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259468", "IGV") medium 0.330 3158 pass no call 15021 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM3394833 58 FFPE AGGAA C/T GTACT CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.2552T>A p.V851D gTc/gAc chr7 55259494 T A =hyperlink("http://localhost:60151/goto?locus=chr7:55259494", "IGV") low 0.147 3158 QD no call 487 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM13195 deleterious(0) probably_damaging(0.997) 32 FFPE GCATG T/A CAAGA CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.2561C>T p.T854I aCa/aTa chr7 55259503 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259503", "IGV") medium 0.240 1349 no call pass 8829 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM87246 deleterious(0) probably_damaging(0.998) 23 FFPE GATCA C/T AGATT CMDL140193 FLD0063 FLD0087 synonymous EGFR c.2484G>A c.2484G>A(p.%3D) ttG/ttA chr7 55259426 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259426", "IGV") medium 0.329 253 no call pass 2663 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs727504312, COSM3639750 likely_benign 10 FFPE TACTT G/A GAGGA CMDL140193 FLD0063 FLD0087 synonymous EGFR c.2556G>A c.2556G>A(p.%3D) aaG/aaA chr7 55259498 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259498", "IGV") medium 0.479 773 pass no call 8273 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM53265 74 FFPE GTCAA G/A ATCAC CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.2591C>T p.A864V gCg/gTg chr7 55259533 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259533", "IGV") medium 0.382 773 pass no call 5768 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM219795, COSM26035 tolerated(0.25) probably_damaging(0.944) 39 FFPE GGGTG C/T GGAAG CMDL140193 FLD0063 FLD0087 nonsynonymous,splice_region EGFR c.2623A>G p.K875E Aaa/Gaa chr7 55259565 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55259565", "IGV") medium 0.518 249 no call pass 4535 EGFR_E00001681524_2 ENSG00000146648 21 of 28 deleterious(0) possibly_damaging(0.892) 7 FFPE GAGGC A/G AAGTA CMDL140193 FLD0063 FLD0087 intron EGFR c.3115-63C>T chr7 55269365 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269365", "IGV") medium 0.409 1238 pass no call 16962 EGFR_E00001773562_1 ENSG00000146648 25 of 27 11 FFPE GCATT C/T AGGAA CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.3143C>T p.A1048V gCt/gTt chr7 55269456 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269456", "IGV") medium 0.238 2398 no call pass 6756 EGFR_E00001773562_1 ENSG00000146648 26 of 28 rs78244461, COSM18445 tolerated(0.28) benign(0.002) T:0.0010 39 FFPE CGTGG C/T TTGCA CMDL140193 FLD0063 FLD0087 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") medium 0.996 1558 pass no call 66127 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.2764G>A p.E922K Gag/Aag chr7 55266472 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266472", "IGV") low 0.500 3 no call LowQual 12 EGFR_E00001779947_1 ENSG00000146648 23 of 28 COSM3639753 deleterious(0.05) benign(0.414) 80 FFPE CCAGC G/A AGATC CMDL140193 FLD0063 FLD0087 intron EGFR c.2848+12G>A chr7 55266568 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266568", "IGV") medium 0.414 3460 pass no call 26124 EGFR_E00001779947_2 ENSG00000146648 23 of 27 56 FFPE GACTG G/A TGGGT CMDL140193 FLD0063 FLD0087 intron EGFR c.2849-10C>T chr7 55267999 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55267999", "IGV") medium 0.325 2901 pass no call 13992 EGFR_E00001790701_1 ENSG00000146648 23 of 27 41 FFPE TCATT C/T CTTCC CMDL140193 FLD0063 FLD0087 intron EGFR c.2849-9C>T chr7 55268000 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268000", "IGV") medium 0.218 2901 pass no call 6669 EGFR_E00001790701_1 ENSG00000146648 23 of 27 42 FFPE CATTC C/T TTCCC CMDL140193 FLD0063 FLD0087 splice_region,intron EGFR c.2849-3C>T chr7 55268006 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268006", "IGV") low 0.118 2484 no call QD 626 EGFR_E00001790701_1 ENSG00000146648 23 of 27 48 FFPE TTCCC C/T AGGCT CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.2857A>G p.I953V Ata/Gta chr7 55268017 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55268017", "IGV") low 0.121 2484 no call QD 778 EGFR_E00001790701_1 ENSG00000146648 24 of 28 deleterious(0) possibly_damaging(0.817) 59 FFPE GGATG A/G TAGAC CMDL140193 FLD0063 FLD0087 synonymous EGFR c.2874C>T c.2874C>T(p.%3D) cgC/cgT chr7 55268034 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268034", "IGV") medium 0.218 2901 pass no call 11150 EGFR_E00001790701_1 ENSG00000146648 24 of 28 COSM1488606 76 FFPE AGTCG C/T CCAAA CMDL140193 FLD0063 FLD0087 synonymous EGFR c.2895C>T c.2895C>T(p.%3D) atC/atT chr7 55268055 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268055", "IGV") medium 0.319 2901 pass no call 19588 EGFR_E00001790701_1 ENSG00000146648 24 of 28 59 FFPE TTGAT C/T ATCGA CMDL140193 FLD0063 FLD0087 splice_region,intron EGFR c.2947-3C>T chr7 55268878 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268878", "IGV") low 0.139 3411 no call QD 1334 EGFR_E00001801208_1 ENSG00000146648 24 of 27 54 FFPE TGCAC C/T AGGGG CMDL140193 FLD0063 FLD0087 nonsynonymous,splice_region EGFR c.2948G>A p.G983E gGg/gAg chr7 55268882 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268882", "IGV") low 0.149 3411 no call QD 635 EGFR_E00001801208_1 ENSG00000146648 25 of 28 deleterious(0.01) probably_damaging(0.94) 58 FFPE CCAGG G/A GGATG CMDL140193 FLD0063 FLD0087 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.356 0.739 3585 3411 pass pass 20685 69242 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.3007G>A p.D1003N Gat/Aat chr7 55268941 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268941", "IGV") low 0.137 3411 no call QD 859 EGFR_E00001801208_1 ENSG00000146648 25 of 28 tolerated(0.13) benign(0.107) 27 FFPE TGATG G/A ATGAA CMDL140193 FLD0063 FLD0087 synonymous EGFR c.3024C>T c.3024C>T(p.%3D) gaC/gaT chr7 55268958 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268958", "IGV") low 0.121 1692 no call QD 2510 EGFR_E00001801208_1 ENSG00000146648 25 of 28 rs747143752 10 FFPE ATGGA C/T GACGT CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.3025G>A p.D1009N Gac/Aac chr7 55268959 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268959", "IGV") low 0.121 1740 QD no call 264 EGFR_E00001801208_1 ENSG00000146648 25 of 28 rs148019583, COSM3639757 deleterious(0.03) possibly_damaging(0.813) 9 FFPE TGGAC G/A ACGTG CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.3022G>A p.D1008N Gac/Aac chr7 55268956 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268956", "IGV") low 0.149 2818 QD no call 1247 EGFR_E00001801208_2 ENSG00000146648 25 of 28 tolerated(0.12) benign(0.002) 18 FFPE ACATG G/A ACGAC CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.3055C>T p.P1019S Cca/Tca chr7 55268989 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268989", "IGV") low 0.162 2818 QD no call 3103 EGFR_E00001801208_2 ENSG00000146648 25 of 28 deleterious(0) probably_damaging(0.994) 51 FFPE TCATC C/T CACAG CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.3100C>T p.L1034F Ctc/Ttc chr7 55269034 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269034", "IGV") low 0.102 3250 no call QD 32 EGFR_E00001801208_2 ENSG00000146648 25 of 28 rs764626121 tolerated(0.07) probably_damaging(0.999) 45 FFPE CTCCC C/T TCCTG CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.2222C>T p.P741L cCc/cTc chr7 55242452 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55242452", "IGV") low 0.111 3977 QD no call 2464 EGFR_Exon19 ENSG00000146648 19 of 28 COSM17570 deleterious(0) probably_damaging(0.998) 58 FFPE AATTC C/T CGTCG CMDL140193 FLD0063 FLD0087 nonsynonymous EGFR c.2272G>A p.E758K Gaa/Aaa chr7 55242502 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55242502", "IGV") low 0.144 3977 QD no call 7006 EGFR_Exon19 ENSG00000146648 19 of 28 deleterious(0) probably_damaging(0.977) 16 FFPE ACAAG G/A AAATC CMDL140193 FLD0063 FLD0087 synonymous TP53 c.133C>T c.133C>T(p.%3D) Ctg/Ttg chr17 7579554 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579554", "IGV") low 0.122 2597 no call QD 2389 EXP0116_TP53_E4 ENSG00000141510 4 of 11 TP53_g.11364C>T, TP53_g.11364C>A 53 FFPE GGACA G/A CATCA CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.110C>T p.S37F tCc/tTc chr17 7579577 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579577", "IGV") low 0.077 2597 no call QD 620 EXP0116_TP53_E4 ENSG00000141510 4 of 11 deleterious(0.02) benign(0.068) 30 FFPE CTTGG G/A ACGGC CMDL140193 FLD0063 FLD0087 splice_region,synonymous KRAS c.111G>A c.111G>A(p.%3D) gaG/gaA chr12 25398208 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398208", "IGV") medium 0.669 3545 pass no call 52071 KRAS_AA_HS ENSG00000133703 2 of 6 25 FFPE TTTAC C/T TCTAT CMDL140193 FLD0063 FLD0087 stop_retained PIK3CA c.3206G>A c.3206G>A(p.%3D) tGa/tAa chr3 178952151 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178952151", "IGV") medium 0.231 3217 no call pass 7570 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 57 FFPE GAACT G/A AAAAG CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.878G>A p.G293E gGa/gAa chr10 89720727 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720727", "IGV") low 0.099 2408 QD no call 1797 PTEN_E00001156315_5 ENSG00000171862 8 of 9 COSM28914, COSM1349605 deleterious(0.04) benign(0.315) 45 FFPE AAATG G/A AAGTC CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.991G>A p.D331N Gac/Aac chr10 89720840 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720840", "IGV") medium 0.990 4006 no call pass 106905 PTEN_E00001156315_7 ENSG00000171862 8 of 9 COSM1263304 deleterious(0.01) probably_damaging(1) 56 FFPE ATAAA G/A ACAAA CMDL140193 FLD0063 FLD0087 intron PTEN c.635-36C>T chr10 89717574 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717574", "IGV") medium 0.275 1510 no call pass 11501 PTEN_E00001156321_1 ENSG00000171862 6 of 8 4 FFPE ATTTC C/T TGTGA CMDL140193 FLD0063 FLD0087 synonymous PTEN c.648G>A c.648G>A(p.%3D) gtG/gtA chr10 89717623 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717623", "IGV") medium 0.212 3007 no call pass 6233 PTEN_E00001156321_1 ENSG00000171862 7 of 9 53 FFPE TTTGT G/A GTCTG CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.653G>A p.C218Y tGc/tAc chr10 89717628 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717628", "IGV") low 0.168 3278 QD no call 2273 PTEN_E00001156321_1 ENSG00000171862 7 of 9 COSM1561201 tolerated(1) benign(0) 58 FFPE GGTCT G/A CCAGC CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.717G>A p.M239I atG/atA chr10 89717692 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717692", "IGV") low 0.209 3007 no call QD 5674 PTEN_E00001156321_1 ENSG00000171862 7 of 9 tolerated(0.75) benign(0.001) 15 FFPE TTCAT G/A TACTT CMDL140193 FLD0063 FLD0087 synonymous PTEN c.537C>T c.537C>T(p.%3D) agC/agT chr10 89711919 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711919", "IGV") medium 0.996 1583 pass no call 67070 PTEN_E00001156327_4 ENSG00000171862 6 of 9 rs779349848 11 FFPE TATAG C/T TACCT CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.631T>C p.C211R Tgc/Cgc chr10 89712013 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89712013", "IGV") medium 0.432 2888 no call pass 22144 PTEN_E00001156327_4 ENSG00000171862 6 of 9 deleterious(0.01) possibly_damaging(0.796) 37 FFPE GAACT T/C GCAGT CMDL140193 FLD0063 FLD0087 intron PTEN c.634+26C>T chr10 89712042 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89712042", "IGV") medium 0.994 1576 pass no call 66214 PTEN_E00001156327_4 ENSG00000171862 6 of 8 8 FFPE TCCTT C/T CATGT CMDL140193 FLD0063 FLD0087 synonymous PTEN c.282C>T c.282C>T(p.%3D) aaC/aaT chr10 89692798 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692798", "IGV") low 0.135 3256 QD no call 678 PTEN_E00001156330_1 ENSG00000171862 5 of 9 COSM921084 31 FFPE CATAA C/T CCACC CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.319G>A p.D107N Gat/Aat chr10 89692835 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692835", "IGV") low 0.163 3256 QD no call 5523 PTEN_E00001156330_1 ENSG00000171862 5 of 9 rs57374291, COSM5212, COSM3397287, COSM30611 tolerated(0.06) benign(0.445) 64 FFPE GTGAA G/A ATCTT CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.322C>T p.L108F Ctt/Ttt chr10 89692838 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692838", "IGV") low 0.135 3256 QD no call 903 PTEN_E00001156330_1 ENSG00000171862 5 of 9 deleterious(0.01) possibly_damaging(0.889) 61 FFPE AAGAT C/T TTGAC CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.346G>A p.D116N Gac/Aac chr10 89692862 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692862", "IGV") low 0.161 3256 QD no call 4594 PTEN_E00001156330_1 ENSG00000171862 5 of 9 tolerated(0.45) benign(0.015) 37 FFPE AAGAT G/A ACAAT CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.451G>A p.A151T Gcc/Acc chr10 89692967 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692967", "IGV") medium 0.617 2410 pass no call 31576 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5080 deleterious(0) probably_damaging(0.955) 58 FFPE AAGAG G/A CCCTA CMDL140193 FLD0063 FLD0087 intron PTEN c.253+28G>A chr10 89690874 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89690874", "IGV") low 0.169 3818 no call QD 2659 PTEN_E00001156337_4 ENSG00000171862 4 of 8 38 FFPE ATGTT G/A TATAA CMDL140193 FLD0063 FLD0087 intron PTEN c.165-25T>C chr10 89685245 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89685245", "IGV") medium 0.299 3511 pass no call 14013 PTEN_E00001156344_1 ENSG00000171862 2 of 8 46 FFPE TGGCT T/C TTTGT CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.139A>G p.R47G Agg/Ggg chr10 89653841 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89653841", "IGV") low 0.162 2844 no call QD 1070 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM28887 deleterious(0) probably_damaging(1) 56 FFPE TATAC A/G GGAAC CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.1043C>T p.T348I aCa/aTa chr10 89725060 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725060", "IGV") low 0.224 3111 no call QD 5738 PTEN_E00001456541_1 ENSG00000171862 9 of 9 COSM1349632, COSM5131 tolerated(0.12) benign(0.033) 38 FFPE CTTCA C/T AAAAA CMDL140193 FLD0063 FLD0087 synonymous PTEN c.1080C>T c.1080C>T(p.%3D) agC/agT chr10 89725097 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725097", "IGV") medium 0.132 1784 pass no call 4484 PTEN_E00001456541_2 ENSG00000171862 9 of 9 9 FFPE GCTAG C/T AGTTC CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.1156G>A p.D386N Gat/Aat chr10 89725173 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725173", "IGV") medium 0.433 3517 no call pass 28153 PTEN_E00001456541_2 ENSG00000171862 9 of 9 deleterious_low_confidence(0.03) possibly_damaging(0.51) 68 FFPE ACTCT G/A ATCCA CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.1159C>T p.P387S Cca/Tca chr10 89725176 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725176", "IGV") low 0.161 3517 no call QD 5117 PTEN_E00001456541_2 ENSG00000171862 9 of 9 tolerated_low_confidence(0.18) benign(0.026) 65 FFPE CTGAT C/T CAGAG CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.1168G>A p.E390K Gaa/Aaa chr10 89725185 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725185", "IGV") medium 0.161 3517 no call pass 13195 PTEN_E00001456541_2 ENSG00000171862 9 of 9 tolerated_low_confidence(0.1) benign(0.006) 56 FFPE AGAAT G/A AACCT CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.1183G>A p.D395N Gat/Aat chr10 89725200 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725200", "IGV") low 0.145 3517 no call QD 369 PTEN_E00001456541_2 ENSG00000171862 9 of 9 deleterious_low_confidence(0.01) benign(0.31) 41 FFPE ATGAA G/A ATCAG CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.1205A>G p.K402R aAa/aGa chr10 89725222 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89725222", "IGV") low 0.122 1772 QD no call 2331 PTEN_E00001456541_2 ENSG00000171862 9 of 9 deleterious_low_confidence(0.03) benign(0.346) 19 FFPE TACAA A/G AGTCT CMDL140193 FLD0063 FLD0087 nonsynonymous PTEN c.58G>A p.G20R Gga/Aga chr10 89624284 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624284", "IGV") low 1.000 2 no call LowQual 22 PTEN_E00001456562_1 ENSG00000171862 1 of 9 COSM5315, COSM1349467 deleterious(0) benign(0.365) 69 FFPE AGGAT G/A GATTC CMDL140193 FLD0063 FLD0087 intron TP53 c.993+147G>A chr17 7576706 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576706", "IGV") medium 0.196 3023 no call pass 16142 TP53_00001404886_13 ENSG00000141510 9 of 10 9 FFPE GTTAG C/T TACAA CMDL140193 FLD0063 FLD0087 intron TP53 c.993+144G>A chr17 7576709 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576709", "IGV") medium 0.194 3023 no call pass 16142 TP53_00001404886_13 ENSG00000141510 9 of 10 6 FFPE AGCTA C/T AACCA CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.619G>A p.D207N Gat/Aat chr17 7578230 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578230", "IGV") low 0.134 1781 no call QD 43 TP53_E00001255919_1 ENSG00000141510 6 of 11 TP53_g.12688G>A, TP53_g.12688G>C, TP53_g.12688G>T, TP53_g.12688del, COSM179817, COSM45289, COSM179819, COSM179818, COSM179820, COSM179821 tolerated(0.06) benign(0.054) 23 FFPE GTCAT C/T CAAAT CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.571C>T p.P191S Cct/Tct chr17 7578278 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578278", "IGV") low 0.185 3414 QD no call 4623 TP53_E00001255919_3 ENSG00000141510 6 of 11 TP53_g.12640del, TP53_g.12640C>T, TP53_g.12640C>A, COSM45341, COSM43702, COSM44867, COSM1684478, COSM1684480, COSM1684482, COSM1684479, COSM1684481 tolerated(0.11) probably_damaging(1) 29 FFPE CTGAG G/A AGGGG CMDL140193 FLD0063 FLD0087 intron TP53 c.559+32C>T chr17 7578339 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578339", "IGV") low 0.179 3414 QD no call 4238 TP53_E00001255919_3 ENSG00000141510 5 of 10 rs748298015 51 FFPE AACCA G/A CCCTG CMDL140193 FLD0063 FLD0087 intron TP53 c.559+11G>A chr17 7578360 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578360", "IGV") low 0.176 3364 no call QD 3284 TP53_E00001255919_3 ENSG00000141510 5 of 10 rs75343564, TP53_g.12558G>T, COSM44284 30 FFPE AGCCC C/T AGCTG CMDL140193 FLD0063 FLD0087 synonymous TP53 c.555C>T c.555C>T(p.%3D) agC/agT chr17 7578375 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578375", "IGV") low 0.145 3414 QD no call 256 TP53_E00001255919_3 ENSG00000141510 5 of 11 TP53_g.12543C>T, TP53_g.12543C>A, TP53_g.12543C>G, COSM45198, COSM44185, COSM45701 15 FFPE CCATC G/A CTATC CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.535C>T p.H179Y Cat/Tat chr17 7578395 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578395", "IGV") low 0.116 2189 no call QD 4037 TP53_E00001255919_5 ENSG00000141510 5 of 11 rs587780070, CM067054, TP53_g.12523C>G, TP53_g.12523C>T, TP53_g.12523C>A, TP53_g.12523del, COSM10768, COSM45520, COSM44776, COSM44151, COSM707884, COSM326728, COSM129848, COSM129849, COSM326727, COSM707885, COSM129851, COSM707887, COSM326729, COSM3388203, COSM3958834, COSM1709730, COSM2744838, COSM129850, COSM707886, COSM326730 deleterious(0) probably_damaging(1) pathogenic 17 FFPE CTCAT G/A GTGGG CMDL140193 FLD0063 FLD0087 synonymous TP53 c.528C>T c.528C>T(p.%3D) tgC/tgT chr17 7578402 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578402", "IGV") low 0.114 2189 no call QD 38 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12516C>G, TP53_g.12516C>A, TP53_g.12516del, TP53_g.12516C>T, COSM44134, COSM11114, COSM43734, COSM179823, COSM1268357, COSM179822, COSM1268358, COSM179824, COSM1268360, COSM179825, COSM1268359 24 FFPE TGGGG G/A CAGCG CMDL140193 FLD0063 FLD0087 synonymous TP53 c.519G>A c.519G>A(p.%3D) gtG/gtA chr17 7578411 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578411", "IGV") low 0.148 2583 QD no call 626 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12507G>A, TP53_g.12507G>T, TP53_g.12507G>C, COSM46083, COSM44517, COSM43752, COSM1610852, COSM1610853, COSM1610855, COSM3717660, COSM3717659, COSM1610854 33 FFPE CGCCT C/T ACAAC CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.502C>T p.H168Y Cac/Tac chr17 7578428 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578428", "IGV") low 0.100 2189 no call QD 2619 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12490del, TP53_g.12490C>A, TP53_g.12490C>G, TP53_g.12490C>T, COSM43861, COSM44307, COSM44713 tolerated(0.07) benign(0.027) 50 FFPE CATGT G/A CTGTG CMDL140193 FLD0063 FLD0087 synonymous TP53 c.492G>A c.492G>A(p.%3D) aaG/aaA chr17 7578438 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578438", "IGV") low 0.134 2583 QD no call 361 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12480G>C, TP53_g.12480del, TP53_g.12480G>A, TP53_g.12480G>T, COSM45103, COSM11369, COSM1194556, COSM1194557, COSM1194559, COSM1194558 60 FFPE GACTG C/T TTGTA CMDL140193 FLD0063 FLD0087 synonymous TP53 c.477C>T c.477C>T(p.%3D) gcC/gcT chr17 7578453 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578453", "IGV") low 0.102 2189 no call QD 2903 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12465C>T, TP53_g.12465del, COSM44130 56 FFPE GCCAT G/A GCGCG CMDL140193 FLD0063 FLD0087 synonymous TP53 c.447C>T c.447C>T(p.%3D) tcC/tcT chr17 7578483 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578483", "IGV") low 0.144 2919 QD no call 1473 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12435C>T, COSM44408 39 FFPE GGTGT G/A GAATC CMDL140193 FLD0063 FLD0087 synonymous TP53 c.411G>A c.411G>A(p.%3D) ctG/ctA chr17 7578519 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578519", "IGV") low 0.143 2919 QD no call 4039 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12399G>T, TP53_g.12399G>A, COSM44649, COSM45993 55 FFPE TTGGC C/T AGTTG CMDL140193 FLD0063 FLD0087 intron TP53 c.74+46C>T chr17 7579793 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579793", "IGV") medium 0.347 955 pass no call 4755 TP53_E00001596491_1 ENSG00000141510 2 of 10 16 FFPE CTGGG G/A TTGGG CMDL140193 FLD0063 FLD0087 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.998 0.995 955 1234 pass pass 36117 54532 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140193 FLD0063 FLD0087 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") medium 0.898 1234 no call pass 30010 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL140193 FLD0063 FLD0087 intron TP53 c.74+32C>T chr17 7579807 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579807", "IGV") medium 0.894 1234 no call pass 30090 TP53_E00001596491_1 ENSG00000141510 2 of 10 30 FFPE GGGGT G/A GTGGG CMDL140193 FLD0063 FLD0087 intron TP53 c.74+23C>T chr17 7579816 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579816", "IGV") medium 0.889 1234 no call pass 30104 TP53_E00001596491_1 ENSG00000141510 2 of 10 39 FFPE GGCCT G/A CCCTT CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.53C>T p.T18I aCa/aTa chr17 7579860 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579860", "IGV") medium 0.885 1234 no call pass 36617 TP53_E00001596491_1 ENSG00000141510 2 of 11 deleterious(0) probably_damaging(0.988) 63 FFPE AAAAT G/A TTTCC CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.34C>T p.P12S Ccc/Tcc chr17 7579879 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579879", "IGV") medium 0.878 1234 no call pass 45069 TP53_E00001596491_1 ENSG00000141510 2 of 11 tolerated(0.51) possibly_damaging(0.864) 44 FFPE AGGGG G/A CTCGA CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.23C>T p.P8L cCt/cTt chr17 7579890 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579890", "IGV") medium 0.328 955 pass no call 4600 TP53_E00001596491_1 ENSG00000141510 2 of 11 tolerated(1) benign(0.001) 33 FFPE CGCTA G/A GATCT CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.17C>T p.S6L tCa/tTa chr17 7579896 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579896", "IGV") medium 0.882 1234 no call pass 29313 TP53_E00001596491_1 ENSG00000141510 2 of 11 TP53_g.11022C>T tolerated(0.54) benign(0.015) 27 FFPE GATCT G/A ACTGC CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.368C>T p.T123I aCt/aTt chr17 7579319 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579319", "IGV") low 0.108 3039 QD no call 370 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11599C>T, TP53_g.11599C>A, COSM44188 deleterious(0.03) possibly_damaging(0.733) 40 FFPE TGCAA G/A TCACA CMDL140193 FLD0063 FLD0087 stop_gained TP53 c.298C>T p.Q100* Cag/Tag chr17 7579389 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579389", "IGV") medium 0.245 215 no call pass 1630 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11529C>T, TP53_g.11529del, COSM44032, COSM1189391, COSM1189392 12 FFPE TTTCT G/A GGAAG CMDL140193 FLD0063 FLD0087 synonymous TP53 c.277C>T c.277C>T(p.%3D) Ctg/Ttg chr17 7579410 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579410", "IGV") medium 0.245 215 no call pass 1630 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11508C>A, TP53_g.11508C>T, COSM166218, COSM1564163, COSM96581, COSM43812, COSM1564164, COSM166220, COSM166219, COSM1564165 33 FFPE TGACA G/A GGGCC CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.253C>T p.P85S Cct/Tct chr17 7579434 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579434", "IGV") medium 0.236 215 no call pass 1389 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11484del, TP53_g.11484C>T, COSM45918 tolerated(0.51) benign(0.019) 57 FFPE TGCAG G/A GGCCG CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 1.000 0.969 187 215 pass pass 7048 7597 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140193 FLD0063 FLD0087 intron TP53 c.782+38G>A chr17 7577461 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577461", "IGV") medium 0.159 1078 no call pass 3324 TP53_E00001665758_1 ENSG00000141510 7 of 10 12 FFPE GGGCA C/T AGCAG CMDL140193 FLD0063 FLD0087 splice_region,intron TP53 c.782+6G>A chr17 7577493 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577493", "IGV") low 0.195 1782 QD no call 2156 TP53_E00001665758_1 ENSG00000141510 7 of 10 44 FFPE TGGCT C/T CTGAC CMDL140193 FLD0063 FLD0087 synonymous TP53 c.759C>T c.759C>T(p.%3D) acC/acT chr17 7577522 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577522", "IGV") low 0.169 1782 QD no call 861 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13396C>T, TP53_g.13396del, TP53_g.13396C>G, COSM44843 73 FFPE ATGAT G/A GTGAG CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.725G>A p.C242Y tGc/tAc chr17 7577556 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577556", "IGV") medium 0.474 1782 pass no call 15766 TP53_E00001665758_1 ENSG00000141510 7 of 11 CM910618, rs121912655, TP53_g.13362G>A, TP53_g.13362G>T, TP53_g.13362G>C, COSM11133, COSM10810, COSM10646, COSM251397, COSM129834, COSM1610838, COSM1610839, COSM251396, COSM129835, COSM3403262, COSM3717642, COSM3378347, COSM2744611, COSM1646852, COSM2744612, COSM1610840, COSM129836, COSM251398 deleterious(0) probably_damaging(1) pathogenic 56 FFPE CCATG C/T AGGAA CMDL140193 FLD0063 FLD0087 synonymous TP53 c.678C>T c.678C>T(p.%3D) ggC/ggT chr17 7577603 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577603", "IGV") low 0.095 1047 no call QD 500 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13315C>G, TP53_g.13315C>T, TP53_g.13315C>A, COSM45999, COSM45868 9 FFPE TCAGA G/A CCAAC CMDL140193 FLD0063 FLD0087 intron TP53 c.1100+34C>T chr17 7573893 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573893", "IGV") medium 0.305 633 no call pass 6410 TP53_E00001728015_1 ENSG00000141510 10 of 10 13 FFPE GCAGG G/A GAGTA CMDL140193 FLD0063 FLD0087 synonymous TP53 c.1074G>A c.1074G>A(p.%3D) gaG/gaA chr17 7573953 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573953", "IGV") medium 0.501 2082 pass no call 20298 TP53_E00001728015_1 ENSG00000141510 10 of 11 TP53_g.16965G>T 73 FFPE CCTGG C/T TCCTT CMDL140193 FLD0063 FLD0087 3_prime_UTR TP53 c.*51C>T chr17 7572876 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572876", "IGV") medium 0.828 1566 pass no call 41005 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs760698953 7 FFPE GGGGA G/A GGAGA CMDL140193 FLD0063 FLD0087 3_prime_UTR TP53 c.*50C>T chr17 7572877 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572877", "IGV") medium 0.943 1566 pass no call 48290 TP53_E00001757276_1 ENSG00000141510 11 of 11 8 FFPE GGGAG G/A GAGAG CMDL140193 FLD0063 FLD0087 3_prime_UTR TP53 c.*49C>T chr17 7572878 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572878", "IGV") medium 0.828 1566 pass no call 51595 TP53_E00001757276_1 ENSG00000141510 11 of 11 9 FFPE GGAGG G/A AGAGA CMDL140193 FLD0063 FLD0087 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") medium 0.704 2763 no call pass 43415 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL140193 FLD0063 FLD0087 3_prime_UTR TP53 c.*24C>T chr17 7572903 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572903", "IGV") low 0.119 2900 QD no call 2401 TP53_E00001757276_1 ENSG00000141510 11 of 11 34 FFPE TGTCA G/A TGGGG CMDL140193 FLD0063 FLD0087 3_prime_UTR TP53 c.*19C>T chr17 7572908 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572908", "IGV") medium 0.823 2900 pass no call 64581 TP53_E00001757276_1 ENSG00000141510 11 of 11 39 FFPE GTGGG G/A AACAA CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.976G>A p.E326K Gaa/Aaa chr17 7576870 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576870", "IGV") medium 0.536 4036 no call pass 44267 TP53_E00001789298_1 ENSG00000141510 9 of 11 TP53_g.14048G>A, TP53_g.14048G>T, COSM11570, COSM307332, COSM2744453, COSM3723941, COSM2744454 tolerated(0.11) probably_damaging(0.971) 64 FFPE ATATT C/T TCCAT CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.863A>G p.N288S aAt/aGt chr17 7577075 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7577075", "IGV") low 0.084 2728 QD no call 676 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13843A>C, TP53_g.13843A>G, COSM44523, COSM96589 tolerated(0.11) benign(0.289) 53 FFPE GGAGA T/C TCTCT CMDL140193 FLD0063 FLD0087 nonsynonymous TP53 c.839G>A p.R280K aGa/aAa chr17 7577099 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577099", "IGV") medium 0.223 2728 pass no call 5533 TP53_E00001789298_3 ENSG00000141510 8 of 11 CM993218, rs121912660, TP53_g.13819G>C, TP53_g.13819G>T, TP53_g.13819G>A, COSM10724, COSM11287, COSM10728, COSM562340, COSM129830, COSM254987, COSM3522694, COSM3733332, COSM3723939, COSM1659144, COSM1646813, COSM1649340 deleterious(0.04) possibly_damaging(0.83) uncertain_significance,pathogenic 68 FFPE GGTCT C/T TCCCA CMDL150011 FLD0064 FLD0088 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.448 0.361 1655 1711 pass pass 25637 19350 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150011 FLD0064 FLD0088 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.507 0.495 1366 1682 pass pass 25414 30883 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150011 FLD0064 FLD0088 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.995 0.996 1400 1693 pass pass 59833 72313 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150011 FLD0064 FLD0088 intron TP53 c.97-41G>A chr17 7579631 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579631", "IGV") low 0.101 1113 no call LowQual,QD 10 EXP0116_TP53_E3 ENSG00000141510 3 of 10 55 FFPE GTCCT C/T AGCCC CMDL150011 FLD0064 FLD0088 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") low 0.116 1113 no call QD 2219 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL150011 FLD0064 FLD0088 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.015 81 QD no call 79 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150011 FLD0064 FLD0088 intron PTEN c.802-12T>C chr10 89720639 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720639", "IGV") low 0.015 95 no call QD 173 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs587781129 benign 46 FFPE TTTTT T/C TTTTT CMDL150011 FLD0064 FLD0088 intron TP53 c.74+56C>T chr17 7579783 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579783", "IGV") low 0.073 1142 no call QD 145 TP53_E00001596491_1 ENSG00000141510 2 of 10 6 FFPE TGCTA G/A GGGGC CMDL150011 FLD0064 FLD0088 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.995 0.994 2050 2285 pass pass 72091 80317 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150011 FLD0064 FLD0088 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.995 0.989 1138 913 pass pass 36900 28652 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150011 FLD0064 FLD0088 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.168 2463 QD no call 3012 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150011 FLD0064 FLD0088 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.170 3018 no call QD 3415 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150015 FLD0065 FLD0089 synonymous EGFR c.2289C>T c.2289C>T(p.%3D) gcC/gcT chr7 55248991 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248991", "IGV") low 0.139 2758 no call QD 2782 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs117420095 likely_benign G:0.0006 71 FFPE GAAGC C/T TACGT CMDL150015 FLD0065 FLD0089 nonsynonymous EGFR c.2300C>T p.A767V gCc/gTc chr7 55249002 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249002", "IGV") low 0.140 2758 no call QD 2774 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs397517107, COSM26445 deleterious(0) probably_damaging(1) uncertain_significance 82 FFPE GATGG C/T CAGCG CMDL150015 FLD0065 FLD0089 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") low 0.092 1362 no call QD 540 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150015 FLD0065 FLD0089 synonymous EGFR c.2382C>T c.2382C>T(p.%3D) ccC/ccT chr7 55249084 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249084", "IGV") low 0.088 1396 QD no call 272 EGFR_E00001601336_1 ENSG00000146648 20 of 28 9 FFPE ATGCC C/T TTCGG CMDL150015 FLD0065 FLD0089 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.997 0.989 1458 1463 pass pass 62672 61883 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150015 FLD0065 FLD0089 intron TP53 c.97-25G>A chr17 7579615 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579615", "IGV") medium 0.174 826 no call pass 3022 EXP0116_TP53_E3 ENSG00000141510 3 of 10 39 FFPE GCAGT C/T AGAGG CMDL150015 FLD0065 FLD0089 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") high 0.701 0.747 1346 826 pass pass 21862 13516 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL150015 FLD0065 FLD0089 intron TP53 c.97-45G>A chr17 7579635 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579635", "IGV") low 0.349 826 no call QD 951 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE TCAGC C/T CCCCA CMDL150015 FLD0065 FLD0089 intron TP53 c.96+54G>A chr17 7579646 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579646", "IGV") medium 0.032 1346 pass no call 4502 EXP0116_TP53_E3 ENSG00000141510 3 of 10 70 FFPE GCCCC C/T CAGCC CMDL150015 FLD0065 FLD0089 intron TP53 c.96+40G>A chr17 7579660 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579660", "IGV") medium 0.282 1346 pass no call 14119 EXP0116_TP53_E3 ENSG00000141510 3 of 10 75 FFPE CAGGT C/T CCCAG CMDL150015 FLD0065 FLD0089 intron TP53 c.96+37G>A chr17 7579663 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579663", "IGV") medium 0.181 1346 pass no call 7424 EXP0116_TP53_E3 ENSG00000141510 3 of 10 72 FFPE GTCCC C/T AGCCC CMDL150015 FLD0065 FLD0089 intron TP53 c.96+32G>A chr17 7579668 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579668", "IGV") medium 0.304 826 no call pass 3990 EXP0116_TP53_E3 ENSG00000141510 3 of 10 67 FFPE CAGCC C/T TCCAG CMDL150015 FLD0065 FLD0089 intron TP53 c.96+22G>A chr17 7579678 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579678", "IGV") medium 0.311 826 no call pass 6976 EXP0116_TP53_E3 ENSG00000141510 3 of 10 57 FFPE GGTCC C/T CAGCC CMDL150015 FLD0065 FLD0089 intron TP53 c.96+11G>A chr17 7579689 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579689", "IGV") low 0.151 1346 QD no call 2225 EXP0116_TP53_E3 ENSG00000141510 3 of 10 46 FFPE CAACC C/T TTGTC CMDL150015 FLD0065 FLD0089 splice_region,intron TP53 c.96+5G>A chr17 7579695 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579695", "IGV") medium 0.161 826 no call pass 3405 EXP0116_TP53_E3 ENSG00000141510 3 of 10 40 FFPE TTGTC C/T TTACC CMDL150015 FLD0065 FLD0089 splice_region,synonymous TP53 c.96G>A c.96G>A(p.%3D) ctG/ctA chr17 7579700 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579700", "IGV") high 0.284 0.160 1346 826 pass pass 6051 3407 EXP0116_TP53_E3 ENSG00000141510 3 of 11 35 FFPE CTTAC C/T AGAAC CMDL150015 FLD0065 FLD0089 nonsynonymous,splice_region TP53 c.95T>C p.L32P cTg/cCg chr17 7579701 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7579701", "IGV") medium 0.303 826 no call pass 3136 EXP0116_TP53_E3 ENSG00000141510 3 of 11 tolerated(0.11) probably_damaging(0.928) 34 FFPE TTACC A/G GAACG CMDL150015 FLD0065 FLD0089 synonymous PIK3CA c.3138A>G c.3138A>G(p.%3D) gcA/gcG chr3 178952083 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178952083", "IGV") high 0.318 0.344 3225 3108 pass pass 19769 22291 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 COSM782, COSM1421006 26 FFPE GATGC A/G CATCA CMDL150015 FLD0065 FLD0089 nonsynonymous PIK3CA c.3140A>G p.H1047R cAt/cGt chr3 178952085 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178952085", "IGV") high 0.318 0.344 3225 3108 pass pass 19813 22240 PIK3CA_Exn21_gap 25710561 ENSG00000121879 21 of 21 rs121913279, COSM776, COSM775, COSM249874, COSM94987, COSM94986 tolerated(0.11) possibly_damaging(0.529) pathogenic 28 FFPE TGCAC A/G TCATG CMDL150015 FLD0065 FLD0089 intron PTEN c.802-10T>C chr10 89720641 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720641", "IGV") low 0.017 87 QD no call 170 PTEN_E00001156315_1m ENSG00000171862 7 of 8 44 FFPE TTTTT T/C TTTTT CMDL150015 FLD0065 FLD0089 splice_region,intron PTEN c.802-8T>A chr10 89720643 T A =hyperlink("http://localhost:60151/goto?locus=chr10:89720643", "IGV") low 0.008 87 QD no call 79 PTEN_E00001156315_1m ENSG00000171862 7 of 8 42 FFPE TTTTT T/A TTTTT CMDL150015 FLD0065 FLD0089 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.002 888 QD no call 109 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL150015 FLD0065 FLD0089 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.991 890 QD no call 113 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150015 FLD0065 FLD0089 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") medium 0.355 946 no call pass 10543 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150015 FLD0065 FLD0089 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.393 0.572 1819 1887 pass pass 17356 24211 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150015 FLD0065 FLD0089 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") low 0.080 1819 QD no call 736 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL150015 FLD0065 FLD0089 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.657 0.600 523 491 pass pass 8567 7205 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150015 FLD0065 FLD0089 3_prime_UTR TP53 c.*51C>T chr17 7572876 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572876", "IGV") low 0.089 1011 no call QD 1004 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs760698953 7 FFPE GGGGA G/A GGAGA CMDL150015 FLD0065 FLD0089 3_prime_UTR TP53 c.*36C>T chr17 7572891 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572891", "IGV") low 0.206 1776 no call QD 1935 TP53_E00001757276_1 ENSG00000141510 11 of 11 22 FFPE GGGGT G/A GGAGG CMDL150015 FLD0065 FLD0089 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") low 0.095 2601 QD no call 1860 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL150015 FLD0065 FLD0089 3_prime_UTR TP53 c.*24C>T chr17 7572903 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572903", "IGV") low 0.098 2601 QD no call 2941 TP53_E00001757276_1 ENSG00000141510 11 of 11 34 FFPE TGTCA G/A TGGGG CMDL150015 FLD0065 FLD0089 3_prime_UTR TP53 c.*20C>T chr17 7572907 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572907", "IGV") medium 0.212 2601 pass no call 12128 TP53_E00001757276_1 ENSG00000141510 11 of 11 38 FFPE AGTGG G/A GAACA CMDL150052 FLD0066 FLD0090 intron BRAF c.1742-21C>T chr7 140453214 G A =hyperlink("http://localhost:60151/goto?locus=chr7:140453214", "IGV") low 0.161 2698 QD no call 2921 BRAF_AA_HS ENSG00000157764 14 of 17 20 FFPE TAAAG G/A AAAAC CMDL150052 FLD0066 FLD0090 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") low 1.000 5 no call pass 132 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150052 FLD0066 FLD0090 nonsynonymous EGFR c.2335G>A p.G779S Ggc/Agc chr7 55249037 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249037", "IGV") low 0.095 1432 no call QD 1390 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs397517119, COSM22942, COSM25016 deleterious(0.03) probably_damaging(1) uncertain_significance 16 FFPE TGCTG G/A GCATC CMDL150052 FLD0066 FLD0090 synonymous EGFR c.2352C>T c.2352C>T(p.%3D) tcC/tcT chr7 55249054 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249054", "IGV") low 0.114 1159 QD no call 1816 EGFR_E00001601336_2 ENSG00000146648 20 of 28 33 FFPE ACCTC C/T ACCGT CMDL150052 FLD0066 FLD0090 synonymous EGFR c.2385C>T c.2385C>T(p.%3D) ttC/ttT chr7 55249087 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249087", "IGV") medium 0.227 2247 pass no call 4695 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs375332959, COSM1568919 66 FFPE CCCTT C/T GGCTG CMDL150052 FLD0066 FLD0090 nonsynonymous EGFR c.2455G>A p.V819M Gtg/Atg chr7 55249157 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249157", "IGV") medium 0.161 1107 pass no call 3344 EGFR_E00001601336_2 ENSG00000146648 20 of 28 deleterious(0.02) probably_damaging(0.999) 38 FFPE GGTGT G/A TGCAG CMDL150052 FLD0066 FLD0090 intron EGFR c.2626-60C>T chr7 55260399 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260399", "IGV") low 0.092 1825 no call QD 1380 EGFR_E00001631695_1 ENSG00000146648 21 of 27 12 FFPE GTTAA C/T TTTTT CMDL150052 FLD0066 FLD0090 synonymous EGFR c.2649G>A c.2649G>A(p.%3D) ttG/ttA chr7 55260482 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260482", "IGV") medium 0.358 3308 pass no call 17414 EGFR_E00001631695_1 ENSG00000146648 22 of 28 71 FFPE GCATT G/A GAATC CMDL150052 FLD0066 FLD0090 stop_gained EGFR c.2694G>A p.W898* tgG/tgA chr7 55260527 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260527", "IGV") medium 0.202 1616 pass no call 5483 EGFR_E00001631695_1 ENSG00000146648 22 of 28 26 FFPE GTCTG G/A AGCTA CMDL150052 FLD0066 FLD0090 splice_region,synonymous EGFR c.2700C>T c.2700C>T(p.%3D) taC/taT chr7 55260533 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260533", "IGV") medium 0.516 1859 no call pass 34191 EGFR_E00001631695_1 ENSG00000146648 22 of 28 rs530256683 T:0.0004 20 FFPE AGCTA C/T GGTGA CMDL150052 FLD0066 FLD0090 intron EGFR c.2470-21G>A chr7 55259391 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259391", "IGV") low 0.130 1384 no call QD 665 EGFR_E00001681524_1 ENSG00000146648 20 of 27 20 FFPE TCACA G/A CAGGG CMDL150052 FLD0066 FLD0090 splice_region,intron EGFR c.2470-3C>T chr7 55259409 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259409", "IGV") medium 0.220 2724 no call pass 7333 EGFR_E00001681524_1 ENSG00000146648 20 of 27 38 FFPE TGTTT C/T AGGGC CMDL150052 FLD0066 FLD0090 nonsynonymous EGFR c.2475G>A p.M825I atG/atA chr7 55259417 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259417", "IGV") medium 0.130 2724 no call pass 7013 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM1578128 deleterious(0) probably_damaging(0.975) 46 FFPE GGCAT G/A AACTA CMDL150052 FLD0066 FLD0090 nonsynonymous EGFR c.2495G>A p.R832H cGc/cAc chr7 55259437 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259437", "IGV") low 0.128 2724 no call QD 4222 EGFR_E00001681524_1 ENSG00000146648 21 of 28 rs772091823, COSM3366978, COSM28514 tolerated(0.27) possibly_damaging(0.485) 66 FFPE CCGTC G/A CTTGG CMDL150052 FLD0066 FLD0090 synonymous EGFR c.2535G>A c.2535G>A(p.%3D) gtG/gtA chr7 55259477 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259477", "IGV") low 0.160 2724 no call QD 1477 EGFR_E00001681524_1 ENSG00000146648 21 of 28 49 FFPE CTGGT G/A AAAAC CMDL150052 FLD0066 FLD0090 synonymous EGFR c.2544G>A c.2544G>A(p.%3D) ccG/ccA chr7 55259486 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259486", "IGV") low 0.161 2724 no call QD 1418 EGFR_E00001681524_1 21264207 ENSG00000146648 21 of 28 rs104886012 not_provided 40 FFPE ACACC G/A CAGCA CMDL150052 FLD0066 FLD0090 nonsynonymous EGFR c.2561C>T p.T854I aCa/aTa chr7 55259503 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259503", "IGV") low 0.110 1519 QD no call 539 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM87246 deleterious(0) probably_damaging(0.998) 23 FFPE GATCA C/T AGATT CMDL150052 FLD0066 FLD0090 synonymous EGFR c.2544G>A c.2544G>A(p.%3D) ccG/ccA chr7 55259486 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259486", "IGV") low 0.146 1692 no call QD 681 EGFR_E00001681524_2 21264207 ENSG00000146648 21 of 28 rs104886012 not_provided 70 FFPE ACACC G/A CAGCA CMDL150052 FLD0066 FLD0090 nonsynonymous EGFR c.2570G>A p.G857E gGg/gAg chr7 55259512 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259512", "IGV") medium 0.228 1692 no call pass 5956 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM370916, COSM250050 deleterious(0) probably_damaging(1) 60 FFPE TTTTG G/A GCTGG CMDL150052 FLD0066 FLD0090 nonsynonymous EGFR c.2591C>T p.A864V gCg/gTg chr7 55259533 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259533", "IGV") medium 0.381 1278 pass no call 8099 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM219795, COSM26035 tolerated(0.25) probably_damaging(0.944) 39 FFPE GGGTG C/T GGAAG CMDL150052 FLD0066 FLD0090 synonymous EGFR c.2592G>A c.2592G>A(p.%3D) gcG/gcA chr7 55259534 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259534", "IGV") medium 0.227 1692 no call pass 5956 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs397517131, COSM1743240 likely_benign 38 FFPE GGTGC G/A GAAGA CMDL150052 FLD0066 FLD0090 intron EGFR c.3115-44G>A chr7 55269384 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269384", "IGV") low 0.173 2843 QD no call 2598 EGFR_E00001773562_1 ENSG00000146648 25 of 27 rs772125966 30 FFPE GAGAT G/A TGGTA CMDL150052 FLD0066 FLD0090 splice_region,intron EGFR c.3162+5G>A chr7 55269480 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269480", "IGV") low 0.176 2836 QD no call 2825 EGFR_E00001773562_1 ENSG00000146648 26 of 27 15 FFPE GGTAT G/A TATGA CMDL150052 FLD0066 FLD0090 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.412 0.608 1396 1524 pass pass 19764 34334 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150052 FLD0066 FLD0090 nonsynonymous EGFR c.2724G>A p.M908I atG/atA chr7 55266432 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266432", "IGV") medium 0.432 3084 no call pass 25908 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(0.999) 49 FFPE TTGAT G/A ACCTT CMDL150052 FLD0066 FLD0090 synonymous EGFR c.2832C>T c.2832C>T(p.%3D) taC/taT chr7 55266540 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266540", "IGV") medium 0.198 1428 pass no call 6839 EGFR_E00001779947_1 ENSG00000146648 23 of 28 12 FFPE GTCTA C/T ATGAT CMDL150052 FLD0066 FLD0090 synonymous EGFR c.2838C>T c.2838C>T(p.%3D) atC/atT chr7 55266546 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266546", "IGV") medium 0.184 1428 pass no call 6169 EGFR_E00001779947_1 ENSG00000146648 23 of 28 6 FFPE ATGAT C/T ATGGT CMDL150052 FLD0066 FLD0090 synonymous EGFR c.2805G>A c.2805G>A(p.%3D) caG/caA chr7 55266513 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266513", "IGV") medium 0.285 3080 pass no call 12025 EGFR_E00001779947_2 ENSG00000146648 23 of 28 37 FFPE CCTCA G/A CCACC CMDL150052 FLD0066 FLD0090 synonymous EGFR c.2844C>T c.2844C>T(p.%3D) gtC/gtT chr7 55266552 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266552", "IGV") low 0.213 3388 no call QD 6438 EGFR_E00001779947_2 ENSG00000146648 23 of 28 72 FFPE ATGGT C/T AAGTG CMDL150052 FLD0066 FLD0090 intron EGFR c.2848+14G>A chr7 55266570 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266570", "IGV") medium 0.322 3080 pass no call 13778 EGFR_E00001779947_2 ENSG00000146648 23 of 27 54 FFPE CTGGT G/A GGTCT CMDL150052 FLD0066 FLD0090 intron EGFR c.2848+54C>T chr7 55266610 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266610", "IGV") low 0.210 3387 no call QD 5873 EGFR_E00001779947_2 ENSG00000146648 23 of 27 14 FFPE CTGCT C/T TTAGC CMDL150052 FLD0066 FLD0090 intron EGFR c.2849-14C>T chr7 55267995 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55267995", "IGV") medium 0.348 3008 no call pass 15840 EGFR_E00001790701_1 ENSG00000146648 23 of 27 37 FFPE TTTCT C/T ATTCC CMDL150052 FLD0066 FLD0090 nonsynonymous EGFR c.2875C>T p.P959S Cca/Tca chr7 55268035 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268035", "IGV") low 0.166 3008 no call QD 1049 EGFR_E00001790701_1 ENSG00000146648 24 of 28 deleterious(0) probably_damaging(1) 77 FFPE GTCGC C/T CAAAG CMDL150052 FLD0066 FLD0090 nonsynonymous EGFR c.2906C>T p.S969F tCc/tTc chr7 55268066 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268066", "IGV") low 0.140 3008 no call QD 210 EGFR_E00001790701_1 ENSG00000146648 24 of 28 deleterious(0) possibly_damaging(0.859) 48 FFPE ATTCT C/T CAAAA CMDL150052 FLD0066 FLD0090 synonymous EGFR c.2907C>T c.2907C>T(p.%3D) tcC/tcT chr7 55268067 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268067", "IGV") low 0.137 2792 QD no call 270 EGFR_E00001790701_1 ENSG00000146648 24 of 28 COSM3412204, COSM3639755 47 FFPE TTCTC C/T AAAAT CMDL150052 FLD0066 FLD0090 nonsynonymous EGFR c.2978C>T p.T993I aCa/aTa chr7 55268912 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268912", "IGV") low 0.107 3246 QD no call 1778 EGFR_E00001801208_1 ENSG00000146648 25 of 28 tolerated(0.23) possibly_damaging(0.831) 56 FFPE TCCTA C/T AGACT CMDL150052 FLD0066 FLD0090 synonymous EGFR c.2988C>T c.2988C>T(p.%3D) aaC/aaT chr7 55268922 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268922", "IGV") low 0.157 3246 QD no call 2102 EGFR_E00001801208_1 ENSG00000146648 25 of 28 rs771085105 46 FFPE TCCAA C/T TTCTA CMDL150052 FLD0066 FLD0090 synonymous EGFR c.3027C>T c.3027C>T(p.%3D) gaC/gaT chr7 55268961 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268961", "IGV") medium 0.157 1580 pass no call 5235 EGFR_E00001801208_1 ENSG00000146648 25 of 28 rs754193639 7 FFPE GACGA C/T GTGGT CMDL150052 FLD0066 FLD0090 intron TP53 c.97-35C>T chr17 7579625 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579625", "IGV") low 0.700 69 pass no call 1290 EXP0116_TP53_E3 ENSG00000141510 3 of 10 49 FFPE GACCA G/A GTCCT CMDL150052 FLD0066 FLD0090 nonsynonymous KRAS c.88G>A p.D30N Gac/Aac chr12 25398231 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398231", "IGV") low 0.108 3251 QD no call 1827 KRAS_AA_HS ENSG00000133703 2 of 6 deleterious(0.04) benign(0.407) 48 FFPE TTCGT C/T CACAA CMDL150052 FLD0066 FLD0090 synonymous KRAS c.60G>A c.60G>A(p.%3D) acG/acA chr12 25398259 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398259", "IGV") low 0.082 3505 no call QD 1116 KRAS_AA_HS ENSG00000133703 2 of 6 rs747140926, COSM1360871, COSM1360873, COSM1360870, COSM1360872 51 FFPE TGTAT C/T GTCAA CMDL150052 FLD0066 FLD0090 nonsynonymous KRAS c.50G>A p.S17N aGt/aAt chr12 25398269 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398269", "IGV") low 0.080 3505 no call QD 1117 KRAS_AA_HS ENSG00000133703 2 of 6 COSM51382 deleterious(0) probably_damaging(0.995) 41 FFPE AGGCA C/T TCTTG CMDL150052 FLD0066 FLD0090 synonymous KRAS c.48G>A c.48G>A(p.%3D) aaG/aaA chr12 25398271 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398271", "IGV") low 0.074 3251 QD no call 438 KRAS_AA_HS ENSG00000133703 2 of 6 39 FFPE GCACT C/T TTGCC CMDL150052 FLD0066 FLD0090 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.009 41 QD no call 43 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150052 FLD0066 FLD0090 splice_region,intron PTEN c.802-8T>C chr10 89720643 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720643", "IGV") low 0.005 41 LowQual,QD no call 14 PTEN_E00001156315_1m ENSG00000171862 7 of 8 42 FFPE TTTTT T/C TTTTT CMDL150052 FLD0066 FLD0090 synonymous PTEN c.816C>T c.816C>T(p.%3D) caC/caT chr10 89720665 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720665", "IGV") low 0.405 50 no call pass 438 PTEN_E00001156315_1m ENSG00000171862 8 of 9 20 FFPE TTTCA C/T TTTTG CMDL150052 FLD0066 FLD0090 nonsynonymous PTEN c.877G>A p.G293R Gga/Aga chr10 89720726 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720726", "IGV") low 0.165 1948 QD no call 1780 PTEN_E00001156315_5 ENSG00000171862 8 of 9 COSM5303, COSM1349604 deleterious(0.01) benign(0.152) 46 FFPE AAAAT G/A GAAGT CMDL150052 FLD0066 FLD0090 intron PTEN c.635-34G>A chr10 89717576 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717576", "IGV") medium 0.188 1641 no call pass 5393 PTEN_E00001156321_1 ENSG00000171862 6 of 8 rs777358609 6 FFPE TTCCT G/A TGAAA CMDL150052 FLD0066 FLD0090 synonymous PTEN c.648G>A c.648G>A(p.%3D) gtG/gtA chr10 89717623 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717623", "IGV") low 0.174 2953 QD no call 3423 PTEN_E00001156321_1 ENSG00000171862 7 of 9 53 FFPE TTTGT G/A GTCTG CMDL150052 FLD0066 FLD0090 synonymous PTEN c.654C>T c.654C>T(p.%3D) tgC/tgT chr10 89717629 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717629", "IGV") low 0.166 2953 QD no call 2266 PTEN_E00001156321_1 ENSG00000171862 7 of 9 COSM5302, COSM1717477 59 FFPE GTCTG C/T CAGCT CMDL150052 FLD0066 FLD0090 synonymous PTEN c.658C>T c.658C>T(p.%3D) Cta/Tta chr10 89717633 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717633", "IGV") low 0.170 2953 QD no call 2487 PTEN_E00001156321_1 ENSG00000171862 7 of 9 63 FFPE GCCAG C/T TAAAG CMDL150052 FLD0066 FLD0090 nonsynonymous PTEN c.709A>G p.K237E Aag/Gag chr10 89717684 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717684", "IGV") medium 0.659 2934 pass no call 44310 PTEN_E00001156321_2 ENSG00000171862 7 of 9 tolerated(0.23) benign(0.038) 45 FFPE AAGAC A/G AGTTC CMDL150052 FLD0066 FLD0090 nonsynonymous PTEN c.751G>A p.G251S Ggt/Agt chr10 89717726 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717726", "IGV") medium 0.343 2934 pass no call 14244 PTEN_E00001156321_2 ENSG00000171862 7 of 9 COSM5220, COSM1349582 deleterious(0.04) possibly_damaging(0.764) 50 FFPE TGTGT G/A GTGAT CMDL150052 FLD0066 FLD0090 intron PTEN c.493-22C>T chr10 89711853 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711853", "IGV") low 0.134 3421 no call QD 34 PTEN_E00001156327_1 ENSG00000171862 5 of 8 58 FFPE GGCTT C/T TCTTT CMDL150052 FLD0066 FLD0090 nonsynonymous,splice_region PTEN c.253G>A p.V85I Gtt/Att chr10 89690846 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89690846", "IGV") low 0.095 3315 QD no call 382 PTEN_E00001156337_4 ENSG00000171862 4 of 9 COSM3397285 deleterious(0.01) probably_damaging(0.934) 38 FFPE GCAGA G/A GTAGG CMDL150052 FLD0066 FLD0090 nonsynonymous PTEN c.1049C>T p.T350I aCa/aTa chr10 89725066 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725066", "IGV") medium 0.335 3069 pass no call 20951 PTEN_E00001456541_1 ENSG00000171862 9 of 9 tolerated(0.16) benign(0.297) 44 FFPE AAAAA C/T AGTAG CMDL150052 FLD0066 FLD0090 nonsynonymous PTEN c.1069C>T p.P357S Cca/Tca chr10 89725086 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725086", "IGV") medium 0.331 3069 pass no call 20540 PTEN_E00001456541_1 ENSG00000171862 9 of 9 COSM1166808 tolerated(1) benign(0) 64 FFPE CAAAT C/T CAGAG CMDL150052 FLD0066 FLD0090 nonsynonymous PTEN c.1075G>A p.A359T Gct/Act chr10 89725092 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725092", "IGV") medium 0.246 3069 pass no call 8476 PTEN_E00001456541_1 ENSG00000171862 9 of 9 tolerated(0.18) benign(0.017) 69 FFPE CAGAG G/A CTAGC CMDL150052 FLD0066 FLD0090 nonsynonymous PTEN c.1085C>T p.S362L tCa/tTa chr10 89725102 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725102", "IGV") medium 0.609 3251 no call pass 42608 PTEN_E00001456541_1 ENSG00000171862 9 of 9 deleterious(0.04) benign(0.282) 59 FFPE CAGTT C/T AACTT CMDL150052 FLD0066 FLD0090 nonsynonymous PTEN c.1148C>T p.T383I aCt/aTt chr10 89725165 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725165", "IGV") medium 0.991 3261 pass no call 104821 PTEN_E00001456541_2 ENSG00000171862 9 of 9 deleterious_low_confidence(0.03) probably_damaging(0.998) 76 FFPE CACCA C/T TGACT CMDL150052 FLD0066 FLD0090 stop_gained PTEN c.1195C>T p.Q399* Caa/Taa chr10 89725212 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725212", "IGV") medium 0.995 3261 pass no call 145246 PTEN_E00001456541_2 ENSG00000171862 9 of 9 29 FFPE ATACA C/T AAATT CMDL150052 FLD0066 FLD0090 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.002 771 no call QD 143 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL150052 FLD0066 FLD0090 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.996 772 no call QD 143 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150052 FLD0066 FLD0090 intron TP53 c.672+32G>A chr17 7578145 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578145", "IGV") low 0.204 2104 QD no call 3987 TP53_E00001255919_1 ENSG00000141510 6 of 10 TP53_g.12773G>T, COSM45538 36 FFPE AACCC C/T TCCTC CMDL150052 FLD0066 FLD0090 intron TP53 c.672+18G>A chr17 7578159 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578159", "IGV") low 0.192 2104 QD no call 3044 TP53_E00001255919_1 ENSG00000141510 6 of 10 rs199578278, TP53_g.12759G>C benign G:0.0014 50 FFPE GAGAC C/T CCAGT CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.568C>T p.P190S Cct/Tct chr17 7578281 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578281", "IGV") low 0.107 3541 no call QD 2183 TP53_E00001255919_3 ENSG00000141510 6 of 11 TP53_g.12637C>A, TP53_g.12637C>T, TP53_g.12637del, TP53_g.12637C>G, COSM44438, COSM44682, COSM44426, COSM44936, COSM1736075, COSM1736077, COSM1736079, COSM1736076, COSM1736078 deleterious(0.04) probably_damaging(0.995) 32 FFPE AGGAG G/A GGCCA CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.566C>T p.A189V gCc/gTc chr17 7578283 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578283", "IGV") low 0.108 3541 no call QD 2350 TP53_E00001255919_3 ENSG00000141510 6 of 11 CM031755, rs121912665, TP53_g.12635C>T, TP53_g.12635del, TP53_g.12635C>A, TP53_g.12635C>G, COSM44349, COSM43698, COSM44454, COSM44203 tolerated(0.06) probably_damaging(1) uncertain_significance,pathogenic 34 FFPE GAGGG G/A CCAGA CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.542G>A p.R181H cGc/cAc chr17 7578388 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578388", "IGV") low 0.192 1811 QD no call 1715 TP53_E00001255919_5 ENSG00000141510 5 of 11 CM942120, rs397514495, CM056067, CM920671, TP53_g.12530G>A, TP53_g.12530G>T, TP53_g.12530del, TP53_g.12530G>C, COSM10738, COSM44152, COSM45046, COSM1386797, COSM99661, COSM1386798, COSM99658, COSM1386800, COSM99659, COSM3388202, COSM3388201, COSM99660, COSM1386799 deleterious(0.02) probably_damaging(0.977) likely_pathogenic,pathogenic,risk_factor 10 FFPE AGCAG C/T GCTCA CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.529C>T p.P177S Ccc/Tcc chr17 7578401 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578401", "IGV") low 0.175 1808 no call QD 1491 TP53_E00001255919_5 ENSG00000141510 5 of 11 rs147002414, TP53_g.12517C>A, TP53_g.12517C>T, TP53_g.12517C>G, TP53_g.12517del, COSM43978, COSM10650, COSM43669, COSM1559483, COSM1559484, COSM1559486, COSM1559485 deleterious(0) probably_damaging(0.964) 23 FFPE GTGGG G/A GCAGC CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.502C>T p.H168Y Cac/Tac chr17 7578428 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578428", "IGV") medium 0.300 1808 no call pass 13681 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12490del, TP53_g.12490C>A, TP53_g.12490C>G, TP53_g.12490C>T, COSM43861, COSM44307, COSM44713 tolerated(0.07) benign(0.027) 50 FFPE CATGT G/A CTGTG CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.497C>T p.S166L tCa/tTa chr17 7578433 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578433", "IGV") low 0.183 1808 no call QD 2937 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12485C>A, TP53_g.12485C>G, TP53_g.12485C>T, COSM44467, COSM11508, COSM44289, COSM369074, COSM1386809, COSM1386810, COSM369075, COSM1386812, COSM369077, COSM1649382, COSM1386811, COSM369076 tolerated(0.05) benign(0.225) 55 FFPE GCTGT G/A ACTGC CMDL150052 FLD0066 FLD0090 synonymous TP53 c.486C>T c.486C>T(p.%3D) atC/atT chr17 7578444 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578444", "IGV") low 0.105 1808 no call QD 2416 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12474C>A, TP53_g.12474C>G, TP53_g.12474C>T, COSM44125, COSM45627, COSM44694 65 FFPE TTGTA G/A ATGGC CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.472C>T p.R158C Cgc/Tgc chr17 7578458 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578458", "IGV") low 0.098 1811 QD no call 1808 TP53_E00001255919_5 ENSG00000141510 5 of 11 rs587780068, CM004341, TP53_g.12460del, TP53_g.12460C>G, TP53_g.12460C>T, TP53_g.12460C>A, COSM43848, COSM43781, COSM11087, COSM3970361, COSM318152, COSM984954, COSM3970360, COSM984956, COSM3970364, COSM318151, COSM984958, COSM3970366, COSM318153, COSM3970359, COSM3970363, COSM3932746, COSM3970362, COSM2744899, COSM1750371, COSM984957, COSM318154, COSM3970365 deleterious(0) probably_damaging(0.996) 51 FFPE GGCGC G/A GACGC CMDL150052 FLD0066 FLD0090 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.995 0.990 1798 276 pass pass 69390 7791 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150052 FLD0066 FLD0090 intron TP53 c.74+36C>T chr17 7579803 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579803", "IGV") medium 0.599 1798 pass no call 23969 TP53_E00001596491_1 ENSG00000141510 2 of 10 26 FFPE GGTGG G/A GGTGG CMDL150052 FLD0066 FLD0090 intron TP53 c.74+12C>T chr17 7579827 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579827", "IGV") low 0.083 1798 QD no call 725 TP53_E00001596491_1 ENSG00000141510 2 of 10 TP53_g.11091C>T, COSM45967 50 FFPE CCAAT G/A GATCC CMDL150052 FLD0066 FLD0090 intron TP53 c.74+11C>T chr17 7579828 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579828", "IGV") low 0.081 1798 QD no call 627 TP53_E00001596491_1 ENSG00000141510 2 of 10 51 FFPE CAATG G/A ATCCA CMDL150052 FLD0066 FLD0090 splice_donor TP53 c.74+2T>C chr17 7579837 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7579837", "IGV") medium 0.234 276 no call pass 853 TP53_E00001596491_1 ENSG00000141510 2 of 10 TP53_g.11081T>C 60 FFPE CACTC A/G CAGTT CMDL150052 FLD0066 FLD0090 synonymous TP53 c.42G>A c.42G>A(p.%3D) ctG/ctA chr17 7579871 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579871", "IGV") medium 0.234 276 no call pass 843 TP53_E00001596491_1 ENSG00000141510 2 of 11 rs773918872 likely_benign 52 FFPE TGACT C/T AGAGG CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.269C>T p.S90F tCc/tTc chr17 7579418 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579418", "IGV") low 0.130 262 no call QD 96 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11500C>T, TP53_g.11500C>A, COSM46099 tolerated(0.18) possibly_damaging(0.707) 41 FFPE GCCAG G/A AGGGG CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.265C>T p.P89S Ccc/Tcc chr17 7579422 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579422", "IGV") low 0.150 296 QD no call 164 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11496C>T, TP53_g.11496del, COSM43688, COSM46063 tolerated(0.52) benign(0.017) 45 FFPE GGAGG G/A GGCTG CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.994 1.000 296 262 pass pass 11823 10419 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.212C>T p.P71L cCc/cTc chr17 7579475 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579475", "IGV") low 0.196 262 no call QD 325 TP53_E00001612188_2 ENSG00000141510 4 of 11 tolerated(0.57) benign(0.004) 26 FFPE CGGGG G/A GAGCA CMDL150052 FLD0066 FLD0090 intron TP53 c.782+40G>A chr17 7577459 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577459", "IGV") medium 0.233 987 pass no call 6082 TP53_E00001665758_1 ENSG00000141510 7 of 10 10 FFPE TGGGG C/T ACAGC CMDL150052 FLD0066 FLD0090 intron TP53 c.782+32C>T chr17 7577467 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577467", "IGV") medium 0.134 987 pass no call 2510 TP53_E00001665758_1 ENSG00000141510 7 of 10 rs368188803 A:0.0002 18 FFPE AGCAG G/A CCAGT CMDL150052 FLD0066 FLD0090 synonymous TP53 c.723C>T c.723C>T(p.%3D) tcC/tcT chr17 7577558 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577558", "IGV") low 0.125 1961 QD no call 1995 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13360C>G, TP53_g.13360C>A, TP53_g.13360del, TP53_g.13360C>T, COSM6530, COSM44158, COSM43824, COSM46004, COSM437498, COSM437499, COSM3718845, COSM2744618, COSM437500 54 FFPE ATGCA G/A GAACT CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.722C>T p.S241F tCc/tTc chr17 7577559 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577559", "IGV") medium 0.122 1961 pass no call 4195 TP53_E00001665758_1 25105660, 21264207 ENSG00000141510 7 of 11 rs28934573, CM920673, TP53_g.13359C>A, TP53_g.13359del, TP53_g.13359C>T, TP53_g.13359C>G, COSM10709, COSM10812, COSM10935, COSM44657, COSM214171, COSM437501, COSM1230110, COSM1230111, COSM214170, COSM437502, COSM3712577, COSM3362448, COSM3522695, COSM2744620, COSM1649402, COSM2744619, COSM214172, COSM437503, COSM1230112 deleterious(0) probably_damaging(1) likely_pathogenic,pathogenic 53 FFPE TGCAG G/A AACTG CMDL150052 FLD0066 FLD0090 synonymous TP53 c.678C>T c.678C>T(p.%3D) ggC/ggT chr17 7577603 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577603", "IGV") low 0.120 974 QD no call 1631 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13315C>G, TP53_g.13315C>T, TP53_g.13315C>A, COSM45999, COSM45868 9 FFPE TCAGA G/A CCAAC CMDL150052 FLD0066 FLD0090 intron TP53 c.1100+28C>T chr17 7573899 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573899", "IGV") medium 0.184 1119 no call pass 5646 TP53_E00001728015_1 ENSG00000141510 10 of 10 19 FFPE GAGTA G/A GGCCA CMDL150052 FLD0066 FLD0090 intron TP53 c.1100+21C>T chr17 7573906 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573906", "IGV") medium 0.181 2229 no call pass 10385 TP53_E00001728015_1 ENSG00000141510 10 of 10 rs2856755 26 FFPE GCCAG G/A AAGGG CMDL150052 FLD0066 FLD0090 intron TP53 c.1100+9C>T chr17 7573918 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573918", "IGV") medium 0.185 2229 no call pass 10194 TP53_E00001728015_1 ENSG00000141510 10 of 10 38 FFPE CTGAG G/A TCACT CMDL150052 FLD0066 FLD0090 splice_region,intron TP53 c.1100+4A>T chr17 7573923 T A =hyperlink("http://localhost:60151/goto?locus=chr17:7573923", "IGV") low 0.165 1315 QD no call 1426 TP53_E00001728015_1 ENSG00000141510 10 of 10 43 FFPE GTCAC T/A CACCT CMDL150052 FLD0066 FLD0090 nonsynonymous,splice_region TP53 c.1099A>T p.S367C Agc/Tgc chr17 7573928 T A =hyperlink("http://localhost:60151/goto?locus=chr17:7573928", "IGV") medium 0.243 1315 pass no call 4157 TP53_E00001728015_1 ENSG00000141510 10 of 11 TP53_g.16990del, COSM45915 tolerated(0.06) benign(0.076) 48 FFPE TCACC T/A GGAGT CMDL150052 FLD0066 FLD0090 stop_gained TP53 c.1060C>T p.Q354* Cag/Tag chr17 7573967 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573967", "IGV") low 0.184 2229 no call QD 1932 TP53_E00001728015_1 ENSG00000141510 10 of 11 rs755394212, TP53_g.16951C>A, TP53_g.16951C>G, COSM562344, COSM46129, COSM562345 70 FFPE AGCCT G/A GGCAT CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.1000G>A p.G334R Ggg/Agg chr17 7574027 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7574027", "IGV") low 0.092 1111 no call QD 795 TP53_E00001728015_1 ENSG00000141510 10 of 11 rs730882028, TP53_g.16891del, TP53_g.16891G>T, COSM48816, COSM1386569 deleterious(0) probably_damaging(0.992) uncertain_significance 10 FFPE ACGCC C/T ACGGA CMDL150052 FLD0066 FLD0090 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.433 2822 no call pass 42440 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150052 FLD0066 FLD0090 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.434 2822 no call pass 34445 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150052 FLD0066 FLD0090 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") medium 0.328 2822 no call pass 33138 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL150052 FLD0066 FLD0090 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") medium 0.333 2822 no call pass 33138 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL150052 FLD0066 FLD0090 3_prime_UTR TP53 c.*31C>T chr17 7572896 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572896", "IGV") medium 0.219 2056 pass no call 5466 TP53_E00001757276_1 ENSG00000141510 11 of 11 27 FFPE GGGAG G/A CTGTC CMDL150052 FLD0066 FLD0090 3_prime_UTR TP53 c.*7C>T chr17 7572920 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572920", "IGV") medium 0.193 2056 pass no call 4366 TP53_E00001757276_1 ENSG00000141510 11 of 11 51 FFPE AAGTG G/A AGAAT CMDL150052 FLD0066 FLD0090 synonymous TP53 c.1140T>C c.1140T>C(p.%3D) caT/caC chr17 7572969 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7572969", "IGV") low 0.190 2822 no call QD 4273 TP53_E00001757276_1 ENSG00000141510 11 of 11 COSM96248 42 FFPE TTTTT A/G TGGCG CMDL150052 FLD0066 FLD0090 synonymous TP53 c.933C>T c.933C>T(p.%3D) aaC/aaT chr17 7576913 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576913", "IGV") medium 0.171 3867 no call pass 11997 TP53_E00001789298_1 ENSG00000141510 9 of 11 rs201601993, TP53_g.14005C>G, TP53_g.14005del, COSM46472, COSM46396 51 FFPE CTGGT G/A TTGTT CMDL150052 FLD0066 FLD0090 nonsynonymous,splice_region TP53 c.920C>T p.A307V gCa/gTa chr17 7576926 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576926", "IGV") low 0.087 3867 no call QD 1830 TP53_E00001789298_1 ENSG00000141510 9 of 11 TP53_g.13992C>T, COSM35846, COSM2150561, COSM2150562 tolerated(0.06) benign(0.053) 38 FFPE GCAGT G/A CTAGG CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.905G>A p.G302E gGg/gAg chr17 7577033 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577033", "IGV") low 0.076 1143 LowQual,QD no call 19 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13885G>A, TP53_g.13885G>C, TP53_g.13885G>T, COSM43988 tolerated(0.11) benign(0.082) 11 FFPE TGCTC C/T CTGGG CMDL150052 FLD0066 FLD0090 synonymous TP53 c.879G>A c.879G>A(p.%3D) ggG/ggA chr17 7577059 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577059", "IGV") medium 0.147 0.188 2229 2843 pass QD 7045 4088 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13859G>T, TP53_g.13859G>C, TP53_g.13859del, TP53_g.13859G>A, COSM44128, COSM45343, COSM44131 37 FFPE GGCTC C/T CCTTT CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.877G>A p.G293R Ggg/Agg chr17 7577061 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577061", "IGV") medium 0.145 2229 pass no call 6985 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs587780076, CM910627, TP53_g.13857del, TP53_g.13857G>C, TP53_g.13857G>T, TP53_g.13857G>A, COSM45670, COSM46165, COSM45417, COSM46261 tolerated(0.49) possibly_damaging(0.761) uncertain_significance 39 FFPE CTCCC C/T TTTCT CMDL150052 FLD0066 FLD0090 nonsynonymous TP53 c.815T>C p.V272A gTg/gCg chr17 7577123 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7577123", "IGV") low 0.135 2229 QD no call 278 TP53_E00001789298_3 ENSG00000141510 8 of 11 CM942122, TP53_g.13795T>G, TP53_g.13795T>C, TP53_g.13795T>A, COSM44294, COSM44870, COSM44580, COSM562337, COSM3958803, COSM3773299, COSM3958805, COSM3958804, COSM3773298 deleterious(0.01) probably_damaging(0.983) 44 FFPE CACGC A/G CCTCA CMDL150061 FLD0067 FLD0091 synonymous EGFR c.2301C>T c.2301C>T(p.%3D) gcC/gcT chr7 55249003 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249003", "IGV") low 0.122 2647 QD no call 528 EGFR_E00001601336_1 ENSG00000146648 20 of 28 83 FFPE ATGGC C/T AGCGT CMDL150061 FLD0067 FLD0091 nonsynonymous EGFR c.2314C>T p.P772S Ccc/Tcc chr7 55249016 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249016", "IGV") medium 0.642 2734 no call pass 38210 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs746677478 deleterious(0) probably_damaging(0.95) 77 FFPE ACAAC C/T CCCAC CMDL150061 FLD0067 FLD0091 synonymous EGFR c.2332C>T c.2332C>T(p.%3D) Ctg/Ttg chr7 55249034 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249034", "IGV") medium 0.215 2647 pass no call 8566 EGFR_E00001601336_1 ENSG00000146648 20 of 28 59 FFPE GCCTG C/T TGGGC CMDL150061 FLD0067 FLD0091 nonsynonymous EGFR c.2344C>T p.L782F Ctc/Ttc chr7 55249046 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249046", "IGV") medium 0.236 2647 pass no call 11066 EGFR_E00001601336_1 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(0.993) 47 FFPE TCTGC C/T TCACC CMDL150061 FLD0067 FLD0091 synonymous EGFR c.2352C>T c.2352C>T(p.%3D) tcC/tcT chr7 55249054 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249054", "IGV") medium 0.237 1506 pass no call 10431 EGFR_E00001601336_1 ENSG00000146648 20 of 28 39 FFPE ACCTC C/T ACCGT CMDL150061 FLD0067 FLD0091 nonsynonymous EGFR c.2354C>T p.T785I aCc/aTc chr7 55249056 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249056", "IGV") medium 0.233 1500 pass no call 11123 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM53288, COSM28930 deleterious(0) probably_damaging(1) 37 FFPE CTCCA C/T CGTGC CMDL150061 FLD0067 FLD0091 synonymous EGFR c.2355C>T c.2355C>T(p.%3D) acC/acT chr7 55249057 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249057", "IGV") medium 0.233 1499 pass no call 10162 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs148188503, COSM1451599 likely_benign 36 FFPE TCCAC C/T GTGCA CMDL150061 FLD0067 FLD0091 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.988 0.980 1499 1320 pass pass 63791 54231 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150061 FLD0067 FLD0091 nonsynonymous EGFR c.2374C>T p.L792F Ctc/Ttc chr7 55249076 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249076", "IGV") medium 0.642 1320 no call pass 32611 EGFR_E00001601336_1 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(1) 17 FFPE CGCAG C/T TCATG CMDL150061 FLD0067 FLD0091 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.992 0.986 1509 1461 pass pass 77110 74256 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150061 FLD0067 FLD0091 intron EGFR c.2470-11C>T chr7 55259401 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259401", "IGV") low 0.135 3083 QD no call 980 EGFR_E00001681524_1 ENSG00000146648 20 of 27 30 FFPE GTCTT C/T TCTGT CMDL150061 FLD0067 FLD0091 nonsynonymous EGFR c.2596G>A p.E866K Gag/Aag chr7 55259538 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259538", "IGV") low 0.176 1918 no call QD 2819 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs756703787, COSM13198 deleterious(0) probably_damaging(0.982) 34 FFPE CGGAA G/A AGAAA CMDL150061 FLD0067 FLD0091 nonsynonymous EGFR c.2617G>A p.G873R Gga/Aga chr7 55259559 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259559", "IGV") low 0.082 832 QD no call 178 EGFR_E00001681524_2 ENSG00000146648 21 of 28 deleterious(0) probably_damaging(0.997) 13 FFPE CAGAA G/A GAGGC CMDL150061 FLD0067 FLD0091 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.980 0.997 1515 1333 pass pass 63877 57898 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150061 FLD0067 FLD0091 synonymous EGFR c.2823C>T c.2823C>T(p.%3D) atC/atT chr7 55266531 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266531", "IGV") low 0.100 1325 no call QD 1422 EGFR_E00001779947_1 ENSG00000146648 23 of 28 rs757493321 21 FFPE ACCAT C/T GATGT CMDL150061 FLD0067 FLD0091 intron TP53 c.97-33G>A chr17 7579623 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579623", "IGV") medium 0.134 778 pass no call 1611 EXP0116_TP53_E3 ENSG00000141510 3 of 10 47 FFPE AGGAC C/T AGGTC CMDL150061 FLD0067 FLD0091 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") medium 0.618 984 no call pass 16280 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL150061 FLD0067 FLD0091 nonsynonymous PIK3CA c.1547G>A p.R516K aGa/aAa chr3 178936005 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936005", "IGV") low 0.085 1773 no call QD 712 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM3724545 tolerated(0.15) benign(0.003) 41 FFPE TAACA G/A ACTAG CMDL150061 FLD0067 FLD0091 nonsynonymous PIK3CA c.1558G>A p.D520N Gac/Aac chr3 178936016 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936016", "IGV") low 0.080 1773 no call QD 489 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM29096 tolerated(0.21) benign(0.004) 52 FFPE CTAGA G/A ACAAT CMDL150061 FLD0067 FLD0091 stop_gained PIK3CA c.1655G>A p.W552* tGg/tAg chr3 178936113 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936113", "IGV") low 0.121 906 QD no call 1436 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 14 FFPE TCTAT G/A GAGTC CMDL150061 FLD0067 FLD0091 intron PTEN c.802-125T>C chr10 89720526 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720526", "IGV") medium 0.130 1175 pass no call 2399 PTEN_E00001156315_1m ENSG00000171862 7 of 8 46 FFPE GATAG T/C TTATT CMDL150061 FLD0067 FLD0091 intron PTEN c.802-87G>A chr10 89720564 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720564", "IGV") low 0.123 1250 no call QD 542 PTEN_E00001156315_1m ENSG00000171862 7 of 8 84 FFPE TAGGT G/A ACAGA CMDL150061 FLD0067 FLD0091 intron PTEN c.802-10T>C chr10 89720641 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720641", "IGV") medium 0.136 249 pass no call 4410 PTEN_E00001156315_1m ENSG00000171862 7 of 8 44 FFPE TTTTT T/C TTTTT CMDL150061 FLD0067 FLD0091 splice_donor PTEN c.801+1G>A chr10 89717777 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717777", "IGV") low 0.108 1490 QD no call 1674 PTEN_E00001156321_4m ENSG00000171862 7 of 8 CS002685, CS992481, CD011189, COSM5970 8 FFPE AAAAG G/A TTTGT CMDL150061 FLD0067 FLD0091 intron PTEN c.801+81G>A chr10 89717857 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717857", "IGV") low 0.101 3012 QD no call 3322 PTEN_E00001156321_4m ENSG00000171862 7 of 8 77 FFPE GTAAG G/A AACTA CMDL150061 FLD0067 FLD0091 intron PTEN c.801+93G>A chr10 89717869 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717869", "IGV") low 0.102 3012 QD no call 3322 PTEN_E00001156321_4m ENSG00000171862 7 of 8 65 FFPE AATTT G/A TTTTC CMDL150061 FLD0067 FLD0091 nonsynonymous PTEN c.359C>T p.A120V gCa/gTa chr10 89692875 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692875", "IGV") low 0.114 1244 no call QD 1817 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CM110123 tolerated(0.11) benign(0.173) 12 FFPE TGTTG C/T AGCAA CMDL150061 FLD0067 FLD0091 nonsynonymous PTEN c.457G>A p.D153N Gat/Aat chr10 89692973 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692973", "IGV") low 0.180 2465 no call QD 2531 PTEN_E00001156330_3 ENSG00000171862 5 of 9 rs9651492, COSM5284, COSM5083 tolerated(0.41) benign(0.173) 52 FFPE CCCTA G/A ATTTC CMDL150061 FLD0067 FLD0091 synonymous PTEN c.84T>C c.84T>C(p.%3D) atT/atC chr10 89653786 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89653786", "IGV") low 0.147 3128 no call QD 646 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM87307 19 FFPE GATAT T/C TATCC CMDL150061 FLD0067 FLD0091 intron TP53 c.74+56C>T chr17 7579783 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579783", "IGV") low 0.090 1185 QD no call 801 TP53_E00001596491_1 ENSG00000141510 2 of 10 6 FFPE TGCTA G/A GGGGC CMDL150061 FLD0067 FLD0091 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.082 1187 QD no call 52 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150061 FLD0067 FLD0091 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") medium 0.129 1190 pass no call 2425 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL150061 FLD0067 FLD0091 intron TP53 c.74+48C>T chr17 7579791 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579791", "IGV") medium 0.158 2239 no call pass 5320 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs765863585 14 FFPE GGCTG G/A GGTTG CMDL150061 FLD0067 FLD0091 intron TP53 c.74+46C>T chr17 7579793 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579793", "IGV") medium 0.180 2244 no call pass 7900 TP53_E00001596491_1 ENSG00000141510 2 of 10 16 FFPE CTGGG G/A TTGGG CMDL150061 FLD0067 FLD0091 intron TP53 c.74+40C>T chr17 7579799 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579799", "IGV") low 0.135 2373 QD no call 2567 TP53_E00001596491_1 ENSG00000141510 2 of 10 22 FFPE TTGGG G/A TGGGG CMDL150061 FLD0067 FLD0091 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.995 0.989 2373 2244 pass pass 92772 83190 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150061 FLD0067 FLD0091 intron TP53 c.74+35C>T chr17 7579804 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579804", "IGV") medium 0.201 2244 no call pass 15766 TP53_E00001596491_1 ENSG00000141510 2 of 10 27 FFPE GTGGG G/A GTGGT CMDL150061 FLD0067 FLD0091 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") low 0.105 2244 no call QD 728 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL150061 FLD0067 FLD0091 intron TP53 c.74+12C>T chr17 7579827 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579827", "IGV") low 0.165 2244 no call QD 3596 TP53_E00001596491_1 ENSG00000141510 2 of 10 TP53_g.11091C>T, COSM45967 50 FFPE CCAAT G/A GATCC CMDL150061 FLD0067 FLD0091 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.991 0.989 992 803 pass pass 36621 31503 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150061 FLD0067 FLD0091 3_prime_UTR TP53 c.*51C>T chr17 7572876 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572876", "IGV") low 0.077 1150 no call QD 1285 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs760698953 7 FFPE GGGGA G/A GGAGA CMDL150061 FLD0067 FLD0091 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.147 2235 no call QD 3897 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150061 FLD0067 FLD0091 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.258 0.099 2175 2235 pass QD 9889 1887 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150061 FLD0067 FLD0091 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") medium 0.165 2175 pass no call 4499 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL150061 FLD0067 FLD0091 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") low 0.144 2235 no call QD 877 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL150061 FLD0067 FLD0091 3_prime_UTR TP53 c.*34C>T chr17 7572893 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572893", "IGV") low 0.221 2235 no call QD 856 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs545818827 A:0.0002 24 FFPE GGTGG G/A AGGCT CMDL150061 FLD0067 FLD0091 3_prime_UTR TP53 c.*19C>T chr17 7572908 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572908", "IGV") low 0.086 2235 no call QD 2495 TP53_E00001757276_1 ENSG00000141510 11 of 11 39 FFPE GTGGG G/A AACAA CMDL150061 FLD0067 FLD0091 3_prime_UTR TP53 c.*10C>T chr17 7572917 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572917", "IGV") low 0.146 0.136 2175 2235 QD QD 2659 672 TP53_E00001757276_1 ENSG00000141510 11 of 11 48 FFPE AAGAA G/A TGGAG CMDL150061 FLD0067 FLD0091 nonsynonymous TP53 c.1169C>T p.P390L cCt/cTt chr17 7572940 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572940", "IGV") low 0.126 2235 no call QD 672 TP53_E00001757276_1 ENSG00000141510 11 of 11 tolerated(0.06) benign(0.04) 71 FFPE AGTCA G/A GCCCT CMDL150061 FLD0067 FLD0091 synonymous TP53 c.1155C>T c.1155C>T(p.%3D) ttC/ttT chr17 7572954 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572954", "IGV") low 0.155 2235 no call QD 1712 TP53_E00001757276_1 ENSG00000141510 11 of 11 57 FFPE GTCTT G/A AACAT CMDL150128 FLD0068 FLD0092 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.347 0.551 1762 1622 pass pass 19292 32530 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150128 FLD0068 FLD0092 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.454 0.456 1598 1520 pass pass 24606 24043 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150128 FLD0068 FLD0092 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.439 0.466 1601 1558 pass pass 24063 25130 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150128 FLD0068 FLD0092 intron TP53 c.97-45G>A chr17 7579635 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579635", "IGV") medium 0.217 1054 no call pass 3327 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE TCAGC C/T CCCCA CMDL150128 FLD0068 FLD0092 intron TP53 c.96+29G>A chr17 7579671 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579671", "IGV") medium 0.200 1160 pass no call 7829 EXP0116_TP53_E3 ENSG00000141510 3 of 10 64 FFPE CCCTC C/T AGGTC CMDL150128 FLD0068 FLD0092 intron TP53 c.96+16G>A chr17 7579684 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579684", "IGV") medium 0.195 1160 pass no call 7829 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs730882012 benign 51 FFPE CAGCC C/T AACCC CMDL150128 FLD0068 FLD0092 splice_region,intron PTEN c.79+5C>T chr10 89624310 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624310", "IGV") low 1.000 2 LowQual no call 22 PTEN_E00001456562_1 ENSG00000171862 1 of 8 43 FFPE TGTAT C/T CATTT CMDL150128 FLD0068 FLD0092 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.002 1036 no call LowQual,QD 23 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL150128 FLD0068 FLD0092 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.990 1036 no call QD 38 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150128 FLD0068 FLD0092 intron TP53 c.74+49C>T chr17 7579790 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579790", "IGV") low 0.111 1021 no call QD 89 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs762400295 13 FFPE GGGCT G/A GGGTT CMDL150128 FLD0068 FLD0092 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.696 0.786 1922 1986 pass pass 36868 47052 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150128 FLD0068 FLD0092 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.993 0.992 1456 1289 pass pass 46989 41556 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150128 FLD0068 FLD0092 nonsynonymous TP53 c.818G>A p.R273H cGt/cAt chr17 7577120 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577120", "IGV") high 0.324 0.325 3236 3059 pass pass 13679 13146 TP53_E00001789298_3 25105660 ENSG00000141510 8 of 11 CM920677, CM010472, rs28934576, CM004342, TP53_g.13798G>C, TP53_g.13798del, TP53_g.13798G>A, TP53_g.13798G>T, COSM10660, COSM43896, COSM44440, COSM10779, COSM318169, COSM99729, COSM165077, COSM3356963, COSM3675521, COSM1640828, COSM1645335, COSM1646808 tolerated(0.13) possibly_damaging(0.631) pathogenic T:0.0002 47 FFPE AAACA C/T GCACC CMDL150136 FLD0069 FLD0093 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") low 0.429 0.667 6 2 pass pass 39 59 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150136 FLD0069 FLD0093 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") low 0.333 0.714 9 7 pass pass 73 165 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150136 FLD0069 FLD0093 synonymous EGFR c.2457G>A c.2457G>A(p.%3D) gtG/gtA chr7 55249159 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249159", "IGV") low 0.286 7 no call pass 32 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs56183713, COSM13400 likely_benign A:0.0002 36 FFPE TGTGT G/A CAGAT CMDL150136 FLD0069 FLD0093 intron EGFR c.3115-26G>A chr7 55269402 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269402", "IGV") low 1.000 2 no call LowQual 22 EGFR_E00001773562_1 ENSG00000146648 25 of 27 rs370814862 48 FFPE TCCAT G/A GGCAA CMDL150136 FLD0069 FLD0093 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") low 1.000 3 no call pass 97 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150136 FLD0069 FLD0093 nonsynonymous EGFR c.2836A>G p.I946V Atc/Gtc chr7 55266544 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55266544", "IGV") low 0.250 8 no call pass 38 EGFR_E00001779947_2 ENSG00000146648 23 of 28 tolerated(0.44) probably_damaging(0.997) 68 FFPE ACATG A/G TCATG CMDL150136 FLD0069 FLD0093 splice_region,intron EGFR c.2848+3G>A chr7 55266559 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266559", "IGV") low 0.250 8 no call pass 38 EGFR_E00001779947_2 ENSG00000146648 23 of 27 65 FFPE AGTGT G/A AGTGA CMDL150136 FLD0069 FLD0093 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") low 0.333 12 pass no call 75 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150136 FLD0069 FLD0093 nonsynonymous EGFR c.2989T>C p.F997L Ttc/Ctc chr7 55268923 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55268923", "IGV") low 0.500 3 no call LowQual 12 EGFR_E00001801208_1 ENSG00000146648 25 of 28 tolerated(0.08) benign(0.168) 45 FFPE CCAAC T/C TCTAC CMDL150136 FLD0069 FLD0093 intron TP53 c.97-48G>A chr17 7579638 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579638", "IGV") low 1.000 2 no call pass 63 EXP0116_TP53_E3 ENSG00000141510 3 of 10 62 FFPE GCCCC C/T CAGCC CMDL150136 FLD0069 FLD0093 intron PTEN c.635-9A>G chr10 89717601 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717601", "IGV") low 0.250 7 pass no call 41 PTEN_E00001156321_1 ENSG00000171862 6 of 8 COSM5932, COSM3724533 31 FFPE ATTTA A/G CCATG CMDL150136 FLD0069 FLD0093 nonsynonymous PTEN c.649G>A p.V217I Gtc/Atc chr10 89717624 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717624", "IGV") low 0.250 7 pass no call 41 PTEN_E00001156321_1 ENSG00000171862 7 of 9 rs121909234, COSM5058 tolerated(0.66) benign(0.122) pathogenic 54 FFPE TTGTG G/A TCTGC CMDL150136 FLD0069 FLD0093 nonsynonymous PTEN c.686C>T p.S229L tCa/tTa chr10 89717661 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717661", "IGV") low 0.250 7 pass no call 41 PTEN_E00001156321_1 ENSG00000171862 7 of 9 CM110118, COSM5295 tolerated(0.56) benign(0.002) 46 FFPE CAATT C/T AGGAC CMDL150136 FLD0069 FLD0093 nonsynonymous PTEN c.691C>T p.P231S Ccc/Tcc chr10 89717666 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717666", "IGV") low 0.250 7 pass no call 41 PTEN_E00001156321_1 ENSG00000171862 7 of 9 tolerated(0.52) benign(0.027) 41 FFPE CAGGA C/T CCACA CMDL150136 FLD0069 FLD0093 synonymous PTEN c.765A>G c.765A>G(p.%3D) gtA/gtG chr10 89717740 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717740", "IGV") low 0.500 3 no call pass 53 PTEN_E00001156321_2 ENSG00000171862 7 of 9 36 FFPE AAAGT A/G GAGTT CMDL150136 FLD0069 FLD0093 nonsynonymous PTEN c.772T>C p.F258L Ttc/Ctc chr10 89717747 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89717747", "IGV") low 0.500 3 no call pass 53 PTEN_E00001156321_2 ENSG00000171862 7 of 9 tolerated(0.07) benign(0.012) 29 FFPE AGTTC T/C TCCAC CMDL150136 FLD0069 FLD0093 intron PTEN c.801+94T>C chr10 89717870 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89717870", "IGV") low 1.000 2 no call LowQual 22 PTEN_E00001156321_4m ENSG00000171862 7 of 8 64 FFPE ATTTG T/C TTTCT CMDL150136 FLD0069 FLD0093 intron PTEN c.493-59A>G chr10 89711816 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89711816", "IGV") low 0.333 11 pass no call 38 PTEN_E00001156327_1 ENSG00000171862 5 of 8 21 FFPE AGTGA A/G ATAAC CMDL150136 FLD0069 FLD0093 splice_region,intron PTEN c.493-3C>T chr10 89711872 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711872", "IGV") low 0.500 4 no call pass 50 PTEN_E00001156327_1 ENSG00000171862 5 of 8 46 FFPE TCCAC C/T AGGGA CMDL150136 FLD0069 FLD0093 nonsynonymous,splice_region PTEN c.493G>A p.G165R Gga/Aga chr10 89711875 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89711875", "IGV") low 0.333 11 pass no call 38 PTEN_E00001156327_1 ENSG00000171862 6 of 9 rs587782603, CM109590, CM110122, COSM5091, COSM36365 deleterious(0) probably_damaging(0.996) pathogenic 43 FFPE ACCAG G/A GAGTA CMDL150136 FLD0069 FLD0093 splice_region,synonymous PTEN c.495A>G c.495A>G(p.%3D) ggA/ggG chr10 89711877 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89711877", "IGV") low 0.500 4 no call pass 50 PTEN_E00001156327_1 ENSG00000171862 6 of 9 COSM314554 41 FFPE CAGGG A/G GTAAC CMDL150136 FLD0069 FLD0093 nonsynonymous PTEN c.530A>G p.Y177C tAt/tGt chr10 89711912 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89711912", "IGV") low 0.500 4 no call LowQual 15 PTEN_E00001156327_1 ENSG00000171862 6 of 9 CD983505, COSM33702, COSM1349561, COSM2154669 deleterious(0) probably_damaging(0.995) 6 FFPE GTATT A/G TTATA CMDL150136 FLD0069 FLD0093 nonsynonymous PTEN c.277C>T p.H93Y Cat/Tat chr10 89692793 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692793", "IGV") low 1.000 2 no call LowQual 22 PTEN_E00001156330_1 ENSG00000171862 5 of 9 CM983500, COSM5283, COSM5043 deleterious(0) probably_damaging(0.964) 26 FFPE AAGAC C/T ATAAC CMDL150136 FLD0069 FLD0093 nonsynonymous PTEN c.151G>A p.D51N Gat/Aat chr10 89653853 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89653853", "IGV") low 0.250 8 pass no call 38 PTEN_E00001156351_1 ENSG00000171862 2 of 9 deleterious(0.04) benign(0.076) 44 FFPE ATATT G/A ATGAT CMDL150136 FLD0069 FLD0093 intron PTEN c.164+12T>C chr10 89653878 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89653878", "IGV") low 0.250 8 pass no call 38 PTEN_E00001156351_1 ENSG00000171862 2 of 8 19 FFPE ATGCT T/C TGATT CMDL150136 FLD0069 FLD0093 intron PTEN c.1027-9T>C chr10 89725035 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89725035", "IGV") low 0.500 2 no call LowQual 22 PTEN_E00001456541_1 ENSG00000171862 8 of 8 13 FFPE TTTTC T/C TTCTC CMDL150136 FLD0069 FLD0093 nonsynonymous PTEN c.1070C>T p.P357L cCa/cTa chr10 89725087 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725087", "IGV") low 0.333 6 pass no call 44 PTEN_E00001456541_1 ENSG00000171862 9 of 9 tolerated(0.58) benign(0.021) 65 FFPE AAATC C/T AGAGG CMDL150136 FLD0069 FLD0093 nonsynonymous PTEN c.1073A>G p.E358G gAg/gGg chr10 89725090 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89725090", "IGV") low 0.333 6 pass no call 44 PTEN_E00001456541_1 ENSG00000171862 9 of 9 tolerated(0.25) benign(0.004) 68 FFPE TCCAG A/G GGCTA CMDL150136 FLD0069 FLD0093 nonsynonymous PTEN c.1099C>T p.P367S Cca/Tca chr10 89725116 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725116", "IGV") low 0.500 2 no call LowQual 22 PTEN_E00001456541_1 ENSG00000171862 9 of 9 tolerated(0.22) benign(0.043) 45 FFPE TAACA C/T CAGAT CMDL150136 FLD0069 FLD0093 nonsynonymous PTEN c.1156G>A p.D386N Gat/Aat chr10 89725173 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725173", "IGV") low 0.200 10 pass no call 32 PTEN_E00001456541_2 ENSG00000171862 9 of 9 deleterious_low_confidence(0.03) possibly_damaging(0.51) 68 FFPE ACTCT G/A ATCCA CMDL150136 FLD0069 FLD0093 nonsynonymous PTEN c.1181A>T p.E394V gAa/gTa chr10 89725198 A T =hyperlink("http://localhost:60151/goto?locus=chr10:89725198", "IGV") low 0.200 10 pass no call 32 PTEN_E00001456541_2 ENSG00000171862 9 of 9 deleterious_low_confidence(0.01) possibly_damaging(0.697) 43 FFPE TGATG A/T AGATC CMDL150136 FLD0069 FLD0093 intron TP53 c.993+143T>C chr17 7576710 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7576710", "IGV") low 0.143 14 LowQual,QD no call 20 TP53_00001404886_13 ENSG00000141510 9 of 10 5 FFPE GCTAC A/G ACCAG CMDL150136 FLD0069 FLD0093 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 1.000 1.000 2 2 pass pass 59 59 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150136 FLD0069 FLD0093 nonsynonymous TP53 c.461G>A p.G154D gGc/gAc chr17 7578469 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578469", "IGV") low 0.500 4 no call pass 50 TP53_E00001255919_5 ENSG00000141510 5 of 11 rs762846821, CM951223, TP53_g.12449G>C, TP53_g.12449G>T, TP53_g.12449G>A, COSM6815, COSM45622, COSM46378, COSM342243, COSM342244, COSM342246, COSM1649372, COSM342245 deleterious(0.02) benign(0.142) 40 FFPE GGGTG C/T CGGGC CMDL150136 FLD0069 FLD0093 nonsynonymous TP53 c.460G>A p.G154S Ggc/Agc chr17 7578470 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578470", "IGV") low 0.500 4 no call pass 50 TP53_E00001255919_5 ENSG00000141510 5 of 11 rs137852789, CD090894, TP53_g.12448G>A, TP53_g.12448del, TP53_g.12448G>T, COSM43692, COSM44715, COSM167463, COSM167462, COSM167464, COSM167465 tolerated(0.14) benign(0.235) not_provided 39 FFPE GGTGC C/T GGGCG CMDL150136 FLD0069 FLD0093 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") low 1.000 6 no call pass 201 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150136 FLD0069 FLD0093 intron TP53 c.74+29C>T chr17 7579810 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579810", "IGV") low 0.333 6 no call pass 44 TP53_E00001596491_1 ENSG00000141510 2 of 10 33 FFPE GTGGT G/A GGCCT CMDL150136 FLD0069 FLD0093 intron TP53 c.74+24A>G chr17 7579815 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7579815", "IGV") low 0.333 6 no call pass 44 TP53_E00001596491_1 ENSG00000141510 2 of 10 38 FFPE GGGCC T/C GCCCT CMDL150136 FLD0069 FLD0093 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") low 1.000 3 no call pass 46 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150136 FLD0069 FLD0093 intron TP53 c.782+13T>C chr17 7577486 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7577486", "IGV") low 1.000 2 no call LowQual 22 TP53_E00001665758_1 ENSG00000141510 7 of 10 37 FFPE TGGCA A/G GTGGC CMDL150136 FLD0069 FLD0093 nonsynonymous TP53 c.749C>T p.P250L cCc/cTc chr17 7577532 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577532", "IGV") low 1.000 2 no call pass 63 TP53_E00001665758_1 ENSG00000141510 7 of 11 CM973401, TP53_g.13386C>T, TP53_g.13386del, TP53_g.13386C>A, COSM10771, COSM44476, COSM45344, COSM212112, COSM212255, COSM212254, COSM212111, COSM3378345, COSM1646862 deleterious(0) probably_damaging(1) 80 FFPE GGATG G/A GCCTC CMDL150136 FLD0069 FLD0093 synonymous TP53 c.747G>A c.747G>A(p.%3D) agG/agA chr17 7577534 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577534", "IGV") low 1.000 2 no call pass 63 TP53_E00001665758_1 25105660, 21264207, 20886114 ENSG00000141510 7 of 11 rs28934571, TP53_g.13384G>T, TP53_g.13384G>A, TP53_g.13384del, TP53_g.13384G>C, COSM44625, COSM10785, COSM10817, COSM131478, COSM1386614, COSM255318, COSM255317, COSM131479, COSM1386615, COSM3717634, COSM3773302, COSM1679495, COSM1646861 pathogenic 78 FFPE ATGGG C/T CTCCG CMDL150136 FLD0069 FLD0093 synonymous TP53 c.1026A>G c.1026A>G(p.%3D) cgA/cgG chr17 7574001 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7574001", "IGV") low 0.500 4 LowQual no call 10 TP53_E00001728015_1 ENSG00000141510 10 of 11 COSM1386559, COSM1386560 36 FFPE AGCTC T/C CGGAA CMDL150136 FLD0069 FLD0093 3_prime_UTR TP53 c.*44T>C chr17 7572883 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7572883", "IGV") low 0.500 4 no call pass 50 TP53_E00001757276_1 ENSG00000141510 11 of 11 14 FFPE GAGAG A/G TGGGG CMDL150136 FLD0069 FLD0093 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.500 4 no call pass 50 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150194 FLD0070 FLD0094 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.600 0.537 1210 1643 pass pass 26480 31284 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150194 FLD0070 FLD0094 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.511 0.496 1245 1540 pass pass 22729 26478 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150194 FLD0070 FLD0094 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.998 0.993 1306 1571 pass pass 56238 66735 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150194 FLD0070 FLD0094 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") medium 0.161 813 pass no call 2463 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL150194 FLD0070 FLD0094 intron PTEN c.802-12T>C chr10 89720639 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720639", "IGV") low 0.013 88 QD no call 78 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs587781129 benign 46 FFPE TTTTT T/C TTTTT CMDL150194 FLD0070 FLD0094 intron PTEN c.802-10T>C chr10 89720641 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720641", "IGV") low 0.010 100 no call QD 48 PTEN_E00001156315_1m ENSG00000171862 7 of 8 44 FFPE TTTTT T/C TTTTT CMDL150194 FLD0070 FLD0094 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.998 0.996 1694 2157 pass pass 55444 73252 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150194 FLD0070 FLD0094 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.991 0.993 1279 1587 pass pass 39030 49767 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150194 FLD0070 FLD0094 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.133 2237 QD no call 656 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150222 FLD0071 FLD0095 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.991 0.984 1642 1802 pass pass 69343 75957 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150222 FLD0071 FLD0095 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.988 0.989 1496 1602 pass pass 68260 74963 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150222 FLD0071 FLD0095 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.993 0.990 1421 1505 pass pass 60550 63838 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150222 FLD0071 FLD0095 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.989 0.989 3496 3899 pass pass 113486 125335 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150222 FLD0071 FLD0095 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") low 0.067 942 QD no call 253 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL150222 FLD0071 FLD0095 intron TP53 c.97-48G>A chr17 7579638 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579638", "IGV") low 0.069 942 QD no call 195 EXP0116_TP53_E3 ENSG00000141510 3 of 10 62 FFPE GCCCC C/T CAGCC CMDL150222 FLD0071 FLD0095 nonsynonymous PIK3CA c.1636C>A p.Q546K Cag/Aag chr3 178936094 C A =hyperlink("http://localhost:60151/goto?locus=chr3:178936094", "IGV") high 0.460 0.442 679 827 pass pass 11415 12801 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 rs121913286, COSM6147, COSM766, COSM255876, COSM1566572 deleterious(0.03) probably_damaging(0.952) pathogenic 33 FFPE CTGAG C/A AGGAG CMDL150222 FLD0071 FLD0095 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.019 100 no call QD 37 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150222 FLD0071 FLD0095 splice_region,intron PTEN c.79+5C>T chr10 89624310 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624310", "IGV") low 0.500 4 pass no call 50 PTEN_E00001456562_1 ENSG00000171862 1 of 8 43 FFPE TGTAT C/T CATTT CMDL150222 FLD0071 FLD0095 splice_region,intron PTEN c.79+8T>C chr10 89624313 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89624313", "IGV") low 0.500 4 pass no call 50 PTEN_E00001456562_1 ENSG00000171862 1 of 8 40 FFPE ATCCA T/C TTCTG CMDL150222 FLD0071 FLD0095 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.991 1302 pass no call 53711 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150222 FLD0071 FLD0095 intron TP53 c.74+56C>T chr17 7579783 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579783", "IGV") low 0.096 1266 no call QD 1114 TP53_E00001596491_1 ENSG00000141510 2 of 10 6 FFPE TGCTA G/A GGGGC CMDL150222 FLD0071 FLD0095 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.094 1131 QD no call 275 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150222 FLD0071 FLD0095 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.991 0.995 2266 2516 pass pass 82213 90097 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150222 FLD0071 FLD0095 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.991 0.995 1368 1496 pass pass 44233 47624 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150222 FLD0071 FLD0095 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.133 3020 no call QD 875 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150222 FLD0071 FLD0095 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") low 0.164 3020 no call QD 4059 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA NTC_013 FLD0072 FLD0096 intron BRAF c.1742-16A>G chr7 140453209 T C =hyperlink("http://localhost:60151/goto?locus=chr7:140453209", "IGV") low 1.000 2 pass no call 63 BRAF_AA_HS ENSG00000157764 14 of 17 25 Blank GTAAG T/C AAAGG NTC_013 FLD0072 FLD0096 intron BRAF c.1742-23T>C chr7 140453216 A G =hyperlink("http://localhost:60151/goto?locus=chr7:140453216", "IGV") low 1.000 2 pass no call 63 BRAF_AA_HS ENSG00000157764 14 of 17 rs776539523 18 Blank AAGGA A/G AACAG NTC_013 FLD0072 FLD0096 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") low 0.500 2 pass no call 50 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 Blank GTGCA G/A CTCAT NTC_013 FLD0072 FLD0096 nonsynonymous EGFR c.2362C>T p.L788F Ctc/Ttc chr7 55249064 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249064", "IGV") low 0.500 4 pass no call 50 EGFR_E00001601336_2 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(1) 43 Blank TGCAG C/T TCATC NTC_013 FLD0072 FLD0096 synonymous EGFR c.2367C>T c.2367C>T(p.%3D) atC/atT chr7 55249069 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249069", "IGV") low 0.500 4 pass no call 50 EGFR_E00001601336_2 ENSG00000146648 20 of 28 48 Blank CTCAT C/T ACGCA NTC_013 FLD0072 FLD0096 nonsynonymous EGFR c.2678A>G p.H893R cAc/cGc chr7 55260511 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55260511", "IGV") low 0.667 5 pass no call 31 EGFR_E00001631695_1 ENSG00000146648 22 of 28 deleterious(0) probably_damaging(1) 42 Blank TACCC A/G CCAGA NTC_013 FLD0072 FLD0096 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") low 1.000 2 pass no call 59 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 Blank GTGAC T/C GTTTG NTC_013 FLD0072 FLD0096 nonsynonymous EGFR c.2815T>C p.C939R Tgt/Cgt chr7 55266523 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266523", "IGV") low 0.500 4 pass no call 50 EGFR_E00001779947_2 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(1) 47 Blank CCATA T/C GTACC NTC_013 FLD0072 FLD0096 nonsynonymous EGFR c.2818A>G p.T940A Acc/Gcc chr7 55266526 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55266526", "IGV") low 0.500 4 pass no call 50 EGFR_E00001779947_2 ENSG00000146648 23 of 28 rs753612121 deleterious(0) probably_damaging(0.998) 50 Blank TATGT A/G CCATC NTC_013 FLD0072 FLD0096 nonsynonymous EGFR c.2822T>C p.I941T aTc/aCc chr7 55266530 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266530", "IGV") low 0.500 4 pass no call 50 EGFR_E00001779947_2 ENSG00000146648 23 of 28 deleterious(0.03) probably_damaging(1) 54 Blank TACCA T/C CGATG NTC_013 FLD0072 FLD0096 nonsynonymous EGFR c.2834T>A p.M945K aTg/aAg chr7 55266542 T A =hyperlink("http://localhost:60151/goto?locus=chr7:55266542", "IGV") low 0.500 4 pass no call 50 EGFR_E00001779947_2 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(0.999) 66 Blank CTACA T/A GATCA NTC_013 FLD0072 FLD0096 nonsynonymous EGFR c.2234A>G p.K745R aAg/aGg chr7 55242464 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55242464", "IGV") low 0.500 7 pass no call 90 EGFR_Exon19 ENSG00000146648 19 of 28 rs121913433, COSM14243, COSM1451585 deleterious(0) probably_damaging(0.999) 54 Blank TATCA A/G GGAAT NTC_013 FLD0072 FLD0096 nonsynonymous PTEN c.656A>T p.Q219L cAg/cTg chr10 89717631 A T =hyperlink("http://localhost:60151/goto?locus=chr10:89717631", "IGV") low 1.000 2 pass no call 63 PTEN_E00001156321_1 ENSG00000171862 7 of 9 deleterious(0.02) possibly_damaging(0.544) 61 Blank CTGCC A/T GCTAA NTC_013 FLD0072 FLD0096 nonsynonymous PTEN c.665T>C p.V222A gTg/gCg chr10 89717640 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89717640", "IGV") low 1.000 2 pass no call 63 PTEN_E00001156321_1 ENSG00000171862 7 of 9 COSM5070 tolerated(0.18) benign(0.065) 67 Blank AAAGG T/C GAAGA NTC_013 FLD0072 FLD0096 nonsynonymous PTEN c.719A>G p.Y240C tAc/tGc chr10 89717694 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717694", "IGV") low 1.000 2 LowQual no call 22 PTEN_E00001156321_1 ENSG00000171862 7 of 9 tolerated(0.18) benign(0.009) 13 Blank CATGT A/G CTTTG NTC_013 FLD0072 FLD0096 synonymous PTEN c.793C>T c.793C>T(p.%3D) Cta/Tta chr10 89717768 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717768", "IGV") low 1.000 2 LowQual no call 22 PTEN_E00001156321_2 ENSG00000171862 7 of 9 8 Blank AGATG C/T TAAAA NTC_013 FLD0072 FLD0096 nonsynonymous PTEN c.302T>C p.I101T aTc/aCc chr10 89692818 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89692818", "IGV") low 1.000 2 LowQual no call 22 PTEN_E00001156330_1 ENSG00000171862 5 of 9 CX983284, CD110165, CM110135, COSM5109, COSM5259 deleterious(0) probably_damaging(0.943) 51 Blank ACTTA T/C CAAAC NTC_013 FLD0072 FLD0096 synonymous PTEN c.351T>C c.351T>C(p.%3D) aaT/aaC chr10 89692867 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89692867", "IGV") low 1.000 2 LowQual no call 22 PTEN_E00001156330_1 ENSG00000171862 5 of 9 32 Blank GACAA T/C CATGT NTC_013 FLD0072 FLD0096 intron PTEN c.1027-10C>T chr10 89725034 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725034", "IGV") low 1.000 2 no call LowQual 22 PTEN_E00001456541_1 ENSG00000171862 8 of 8 12 Blank ATTTT C/T TTTCT NTC_013 FLD0072 FLD0096 synonymous PTEN c.1033C>T c.1033C>T(p.%3D) Ctg/Ttg chr10 89725050 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725050", "IGV") low 1.000 2 no call LowQual 22 PTEN_E00001456541_1 ENSG00000171862 9 of 9 CM043775 28 Blank TGAAG C/T TGTAC NTC_013 FLD0072 FLD0096 nonsynonymous PTEN c.1073A>G p.E358G gAg/gGg chr10 89725090 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89725090", "IGV") low 1.000 2 no call LowQual 22 PTEN_E00001456541_1 ENSG00000171862 9 of 9 tolerated(0.25) benign(0.004) 68 Blank TCCAG A/G GGCTA NTC_013 FLD0072 FLD0096 synonymous PTEN c.9C>T c.9C>T(p.%3D) gcC/gcT chr10 89624235 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624235", "IGV") low 1.000 2 no call LowQual 22 PTEN_E00001456562_1 ENSG00000171862 1 of 9 COSM1561221 41 Blank ACAGC C/T ATCAT NTC_013 FLD0072 FLD0096 intron TP53 c.993+238G>A chr17 7576615 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576615", "IGV") low 1.000 2 no call LowQual 22 TP53_00001404886_13 ENSG00000141510 9 of 10 8 Blank ATTTT C/T ATGCT NTC_013 FLD0072 FLD0096 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 1.000 2 pass no call 59 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 Blank TCACC T/C GGAGG NTC_013 FLD0072 FLD0096 nonsynonymous TP53 c.442G>A p.D148N Gat/Aat chr17 7578488 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578488", "IGV") low 0.333 4 LowQual no call 10 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12430del, TP53_g.12430G>A, TP53_g.12430G>T, COSM44043, COSM46105, COSM95383, COSM45913 tolerated(0.44) benign(0.003) 21 Blank GGAAT C/T AACCC NTC_013 FLD0072 FLD0096 intron TP53 c.74+47C>T chr17 7579792 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579792", "IGV") low 0.333 6 pass no call 44 TP53_E00001596491_1 ENSG00000141510 2 of 10 15 Blank GCTGG G/A GTTGG NTC_013 FLD0072 FLD0096 intron TP53 c.74+41C>T chr17 7579798 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579798", "IGV") low 0.333 6 pass no call 44 TP53_E00001596491_1 ENSG00000141510 2 of 10 21 Blank GTTGG G/A GTGGG NTC_013 FLD0072 FLD0096 intron TP53 c.74+40C>T chr17 7579799 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579799", "IGV") low 0.333 6 pass no call 44 TP53_E00001596491_1 ENSG00000141510 2 of 10 22 Blank TTGGG G/A TGGGG NTC_013 FLD0072 FLD0096 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") low 1.000 6 pass no call 242 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 Blank GGGGT G/C GGGGT NTC_013 FLD0072 FLD0096 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") low 0.333 6 pass no call 44 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 Blank TGGGG G/A TGGTG NTC_013 FLD0072 FLD0096 synonymous TP53 c.54A>G c.54A>G(p.%3D) acA/acG chr17 7579859 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7579859", "IGV") low 0.333 6 pass no call 44 TP53_E00001596491_1 ENSG00000141510 2 of 11 TP53_g.11059A>T, COSM45385 64 Blank GAAAA T/C GTTTC NTC_013 FLD0072 FLD0096 nonsynonymous TP53 c.52A>G p.T18A Aca/Gca chr17 7579861 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7579861", "IGV") low 0.333 6 pass no call 44 TP53_E00001596491_1 ENSG00000141510 2 of 11 COSM220785, COSM220787, COSM220786, COSM220788 deleterious(0.01) possibly_damaging(0.9) 62 Blank AAATG T/C TTCCT NTC_013 FLD0072 FLD0096 synonymous TP53 c.333G>A c.333G>A(p.%3D) ctG/ctA chr17 7579354 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579354", "IGV") low 1.000 2 no call LowQual 22 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11564del, TP53_g.11564G>A, COSM45355, COSM307336 52 Blank AAGCC C/T AGACG NTC_013 FLD0072 FLD0096 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") low 1.000 6 pass no call 120 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 Blank CCACG G/C GGGGA NTC_013 FLD0072 FLD0096 synonymous TP53 c.1059C>T c.1059C>T(p.%3D) gcC/gcT chr17 7573968 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573968", "IGV") low 0.500 3 no call LowQual 12 TP53_E00001728015_1 ENSG00000141510 10 of 11 69 Blank GCCTG G/A GCATC NTC_013 FLD0072 FLD0096 3_prime_UTR TP53 c.*34C>T chr17 7572893 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572893", "IGV") low 1.000 4 pass no call 111 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs545818827 A:0.0002 24 Blank GGTGG G/A AGGCT NTC_013 FLD0072 FLD0096 splice_donor TP53 c.993+1G>A chr17 7576852 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576852", "IGV") low 0.500 4 LowQual no call 30 TP53_E00001789298_1 22291954 ENSG00000141510 9 of 10 rs11575997, CD002536, TP53_g.14066del, TP53_g.14066G>C, TP53_g.14066G>A, TP53_g.14066G>T, COSM44295, COSM119021, COSM6918, COSM323936, COSM165065, COSM119022, COSM4151771, COSM3717623, COSM4151770, COSM3717622 46 Blank TAGTA C/T CTGAA NTC_013 FLD0072 FLD0096 splice_region,intron TP53 c.920-8T>C chr17 7576934 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7576934", "IGV") low 1.000 2 no call LowQual 22 TP53_E00001789298_2 ENSG00000141510 8 of 10 9 Blank AGGAA A/G GAGGC NTC_013 FLD0072 FLD0096 intron TP53 c.919+44A>T chr17 7576975 T A =hyperlink("http://localhost:60151/goto?locus=chr17:7576975", "IGV") low 0.167 11 LowQual no call 29 TP53_E00001789298_2 ENSG00000141510 8 of 10 rs144496254 C:0.0002 50 Blank ATAAC T/A GCACC NTC_013 FLD0072 FLD0096 intron TP53 c.919+37A>G chr17 7576982 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7576982", "IGV") low 0.167 11 LowQual no call 29 TP53_E00001789298_2 ENSG00000141510 8 of 10 57 Blank CACCC T/C TGGTC NTC_013 FLD0072 FLD0096 synonymous TP53 c.879G>A c.879G>A(p.%3D) ggG/ggA chr17 7577059 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577059", "IGV") low 1.000 2 no call LowQual 22 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13859G>T, TP53_g.13859G>C, TP53_g.13859del, TP53_g.13859G>A, COSM44128, COSM45343, COSM44131 37 Blank GGCTC C/T CCTTT CMDL140011 FLD0097 FLD0121 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.509 0.524 1984 1825 pass pass 36034 35001 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140011 FLD0097 FLD0121 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.509 0.507 1839 1608 pass pass 33441 29957 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140011 FLD0097 FLD0121 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.992 0.993 2207 1738 pass pass 93154 73418 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140011 FLD0097 FLD0121 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.997 1458 no call pass 60989 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140011 FLD0097 FLD0121 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.581 0.563 2157 2003 pass pass 27297 25552 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140011 FLD0097 FLD0121 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.860 0.824 1154 1431 pass pass 26952 30926 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140019 FLD0098 FLD0122 intron EGFR c.2284-15T>C chr7 55248971 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55248971", "IGV") low 1.000 2 LowQual no call 22 EGFR_E00001601336_1 ENSG00000146648 19 of 27 51 FFPE GTGCC T/C CTCCC CMDL140019 FLD0098 FLD0122 nonsynonymous EGFR c.2315C>T p.P772L cCc/cTc chr7 55249017 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249017", "IGV") low 1.000 2 LowQual no call 22 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM115794 deleterious(0) probably_damaging(0.986) 76 FFPE CAACC C/T CCACG CMDL140019 FLD0098 FLD0122 intron EGFR c.2469+13G>A chr7 55249184 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249184", "IGV") low 0.083 1405 no call QD 375 EGFR_E00001601336_2 ENSG00000146648 20 of 27 rs764099332, COSM17569 11 FFPE GGGAA G/A GGAGA CMDL140019 FLD0098 FLD0122 splice_region,intron EGFR c.2701+3G>A chr7 55260537 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260537", "IGV") low 0.084 2057 QD no call 383 EGFR_E00001631695_1 ENSG00000146648 22 of 27 16 FFPE ACGGT G/A AGTCA CMDL140019 FLD0098 FLD0122 intron EGFR c.2470-9C>T chr7 55259403 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259403", "IGV") low 0.123 3353 no call QD 37 EGFR_E00001681524_1 ENSG00000146648 20 of 27 32 FFPE CTTCT C/T TGTTT CMDL140019 FLD0098 FLD0122 nonsynonymous EGFR c.2485G>A p.E829K Gag/Aag chr7 55259427 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259427", "IGV") medium 0.171 877 pass no call 3304 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM53291 deleterious(0) probably_damaging(0.992) 11 FFPE ACTTG G/A AGGAC CMDL140019 FLD0098 FLD0122 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.995 0.994 1618 1154 pass pass 69703 50127 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140019 FLD0098 FLD0122 synonymous EGFR c.2766G>A c.2766G>A(p.%3D) gaG/gaA chr7 55266474 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266474", "IGV") low 0.192 2318 no call QD 2780 EGFR_E00001779947_1 ENSG00000146648 23 of 28 78 FFPE AGCGA G/A ATCTC CMDL140019 FLD0098 FLD0122 nonsynonymous EGFR c.2794C>T p.R932C Cgc/Tgc chr7 55266502 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266502", "IGV") low 0.154 2318 no call QD 2009 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(1) 50 FFPE GAGAA C/T GCCTC CMDL140019 FLD0098 FLD0122 splice_region,intron EGFR c.2848+7G>A chr7 55266563 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266563", "IGV") low 0.094 3207 no call QD 2345 EGFR_E00001779947_2 ENSG00000146648 23 of 27 61 FFPE TGAGT G/A ACTGG CMDL140019 FLD0098 FLD0122 intron EGFR c.2848+14G>A chr7 55266570 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266570", "IGV") low 0.078 3207 no call QD 1270 EGFR_E00001779947_2 ENSG00000146648 23 of 27 54 FFPE CTGGT G/A GGTCT CMDL140019 FLD0098 FLD0122 intron EGFR c.2848+20G>A chr7 55266576 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266576", "IGV") low 0.077 3207 no call QD 1270 EGFR_E00001779947_2 ENSG00000146648 23 of 27 48 FFPE GGTCT G/A TCCAC CMDL140019 FLD0098 FLD0122 intron TP53 c.97-41G>A chr17 7579631 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579631", "IGV") low 1.000 47 pass no call 1049 EXP0116_TP53_E3 ENSG00000141510 3 of 10 55 FFPE GTCCT C/T AGCCC CMDL140019 FLD0098 FLD0122 nonsynonymous TP53 c.91G>A p.V31I Gtt/Att chr17 7579705 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579705", "IGV") low 1.000 47 pass no call 1119 EXP0116_TP53_E3 ENSG00000141510 3 of 11 rs201753350, CM074603, TP53_g.11213G>A, COSM45360, COSM1717726, COSM1717728, COSM1717727, COSM1717729 tolerated(0.24) benign(0.002) uncertain_significance,not_provided,likely_benign T:0.0018 30 FFPE CAGAA C/T GTTGT CMDL140019 FLD0098 FLD0122 nonsynonymous PIK3CA c.1658G>A p.S553N aGt/aAt chr3 178936116 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936116", "IGV") medium 0.169 308 no call pass 1140 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM29106, COSM1666661 tolerated(0.1) benign(0.068) 11 FFPE ATGGA G/A TCACA CMDL140019 FLD0098 FLD0122 nonsynonymous PIK3CA c.3140A>G p.H1047R cAt/cGt chr3 178952085 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178952085", "IGV") high 0.251 0.244 3055 2994 pass pass 6776 9650 PIK3CA_Exn21_gap 25710561 ENSG00000121879 21 of 21 rs121913279, COSM776, COSM775, COSM249874, COSM94987, COSM94986 tolerated(0.11) possibly_damaging(0.529) pathogenic 28 FFPE TGCAC A/G TCATG CMDL140019 FLD0098 FLD0122 3_prime_UTR PIK3CA c.*29T>C chr3 178952181 T C =hyperlink("http://localhost:60151/goto?locus=chr3:178952181", "IGV") high 0.380 0.507 3055 3015 pass pass 22272 29309 PIK3CA_Exn21_gap 25834816 ENSG00000121879 21 of 21 rs141178472, COSM249908 C:0.0006 27 FFPE CTCAC T/C CTGGA CMDL140019 FLD0098 FLD0122 intron PTEN c.802-142A>G chr10 89720509 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89720509", "IGV") low 0.101 1226 no call QD 1312 PTEN_E00001156315_1m ENSG00000171862 7 of 8 29 FFPE TATTC A/G GAATA CMDL140019 FLD0098 FLD0122 intron PTEN c.802-34C>T chr10 89720617 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720617", "IGV") medium 0.221 121 pass no call 243 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs531071483 68 FFPE CATTT C/T ATTTC CMDL140019 FLD0098 FLD0122 nonsynonymous PTEN c.698G>A p.R233Q cGa/cAa chr10 89717673 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717673", "IGV") low 0.172 3509 QD no call 3334 PTEN_E00001156321_2 ENSG00000171862 7 of 9 rs770025422, COSM1297486 tolerated(0.12) benign(0.156) 34 FFPE CACAC G/A ACGGG CMDL140019 FLD0098 FLD0122 synonymous PTEN c.735G>A c.735G>A(p.%3D) caG/caA chr10 89717710 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717710", "IGV") low 0.173 3509 QD no call 3340 PTEN_E00001156321_2 ENSG00000171862 7 of 9 66 FFPE CCTCA G/A CCGTT CMDL140019 FLD0098 FLD0122 splice_region,intron PTEN c.801+6T>C chr10 89717782 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89717782", "IGV") low 0.126 1666 QD no call 1897 PTEN_E00001156321_4m ENSG00000171862 7 of 8 13 FFPE GTTTG T/C ACTTT CMDL140019 FLD0098 FLD0122 intron PTEN c.801+41G>A chr10 89717817 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717817", "IGV") low 0.214 3377 QD no call 6076 PTEN_E00001156321_4m ENSG00000171862 7 of 8 48 FFPE AATAA G/A GACAG CMDL140019 FLD0098 FLD0122 intron PTEN c.801+129G>A chr10 89717905 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717905", "IGV") low 0.132 1689 QD no call 2922 PTEN_E00001156321_4m ENSG00000171862 7 of 8 29 FFPE ACTCT G/A GCATT CMDL140019 FLD0098 FLD0122 intron PTEN c.801+152G>A chr10 89717928 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717928", "IGV") medium 0.158 1688 pass no call 4862 PTEN_E00001156321_4m ENSG00000171862 7 of 8 6 FFPE TAAGG G/A TAAAT CMDL140019 FLD0098 FLD0122 nonsynonymous PTEN c.302T>C p.I101T aTc/aCc chr10 89692818 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89692818", "IGV") medium 0.191 0.345 3936 3550 QD pass 6078 22623 PTEN_E00001156330_1 ENSG00000171862 5 of 9 CX983284, CD110165, CM110135, COSM5109, COSM5259 deleterious(0) probably_damaging(0.943) 51 FFPE ACTTA T/C CAAAC CMDL140019 FLD0098 FLD0122 nonsynonymous PTEN c.364A>G p.I122V Att/Gtt chr10 89692880 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89692880", "IGV") medium 0.475 1398 no call pass 23649 PTEN_E00001156330_3 ENSG00000171862 5 of 9 tolerated(0.68) benign(0.14) 17 FFPE CAGCA A/G TTCAC CMDL140019 FLD0098 FLD0122 nonsynonymous PTEN c.451G>A p.A151T Gcc/Acc chr10 89692967 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692967", "IGV") medium 0.253 2753 no call pass 7149 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5080 deleterious(0) probably_damaging(0.955) 58 FFPE AAGAG G/A CCCTA CMDL140019 FLD0098 FLD0122 nonsynonymous PTEN c.482G>A p.R161K aGa/aAa chr10 89692998 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692998", "IGV") medium 0.255 1355 no call pass 9683 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM41781, COSM41773 tolerated(0.48) benign(0.012) 27 FFPE GACCA G/A AGACA CMDL140019 FLD0098 FLD0122 nonsynonymous PTEN c.112C>T p.P38S Cct/Tct chr10 89653814 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653814", "IGV") low 0.147 3457 no call QD 1101 PTEN_E00001156351_1 ENSG00000171862 2 of 9 rs587780004, COSM5142 deleterious(0) probably_damaging(0.991) likely_pathogenic 47 FFPE GATTT C/T CTGCA CMDL140019 FLD0098 FLD0122 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.121 1270 QD no call 2409 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL140019 FLD0098 FLD0122 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") medium 0.144 1272 pass no call 4501 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL140019 FLD0098 FLD0122 intron TP53 c.74+48C>T chr17 7579791 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579791", "IGV") low 0.234 1452 no call QD 1536 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs765863585 14 FFPE GGCTG G/A GGTTG CMDL140019 FLD0098 FLD0122 intron TP53 c.74+47C>T chr17 7579792 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579792", "IGV") medium 0.384 2500 pass no call 21270 TP53_E00001596491_1 ENSG00000141510 2 of 10 15 FFPE GCTGG G/A GTTGG CMDL140019 FLD0098 FLD0122 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.727 0.562 2500 1454 pass pass 67814 22347 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140019 FLD0098 FLD0122 intron TP53 c.74+36C>T chr17 7579803 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579803", "IGV") low 0.142 1454 no call QD 856 TP53_E00001596491_1 ENSG00000141510 2 of 10 26 FFPE GGTGG G/A GGTGG CMDL140019 FLD0098 FLD0122 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") medium 0.383 2500 pass no call 21314 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL140019 FLD0098 FLD0122 intron TP53 c.74+31C>T chr17 7579808 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579808", "IGV") low 0.141 2500 QD no call 2943 TP53_E00001596491_1 ENSG00000141510 2 of 10 31 FFPE GGGTG G/A TGGGC CMDL140019 FLD0098 FLD0122 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.794 0.846 308 330 pass pass 6253 6372 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140019 FLD0098 FLD0122 intron TP53 c.782+32C>T chr17 7577467 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577467", "IGV") low 0.078 1490 QD no call 275 TP53_E00001665758_1 ENSG00000141510 7 of 10 rs368188803 A:0.0002 18 FFPE AGCAG G/A CCAGT CMDL140019 FLD0098 FLD0122 intron TP53 c.782+24C>T chr17 7577475 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577475", "IGV") low 0.080 1490 QD no call 878 TP53_E00001665758_1 ENSG00000141510 7 of 10 TP53_g.13443C>G, TP53_g.13443C>A, COSM46380, COSM45690 26 FFPE AGTGT G/A CAGGG CMDL140019 FLD0098 FLD0122 splice_region,intron TP53 c.994-3C>T chr17 7574036 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7574036", "IGV") low 0.080 1209 no call QD 46 TP53_E00001728015_1 ENSG00000141510 9 of 10 1 FFPE GATCT G/A CAGCA CMDL140019 FLD0098 FLD0122 3_prime_UTR TP53 c.*45C>T chr17 7572882 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572882", "IGV") medium 0.276 2545 no call pass 16509 TP53_E00001757276_1 ENSG00000141510 11 of 11 13 FFPE GGAGA G/A ATGGG CMDL140019 FLD0098 FLD0122 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.274 2545 no call pass 15021 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140019 FLD0098 FLD0122 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.274 2890 pass no call 11402 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140019 FLD0098 FLD0122 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") low 0.136 0.172 2890 2545 QD QD 1113 3560 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL140019 FLD0098 FLD0122 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") low 0.133 2890 QD no call 106 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL140019 FLD0098 FLD0122 3_prime_UTR TP53 c.*8C>T chr17 7572919 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572919", "IGV") medium 0.155 2890 pass no call 8820 TP53_E00001757276_1 ENSG00000141510 11 of 11 50 FFPE GAAGT G/A GAGAA CMDL140019 FLD0098 FLD0122 3_prime_UTR TP53 c.*1C>T chr17 7572926 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572926", "IGV") medium 0.258 2890 pass no call 10504 TP53_E00001757276_1 ENSG00000141510 11 of 11 57 FFPE AGAAT G/A TCAGT CMDL140019 FLD0098 FLD0122 synonymous TP53 c.1179C>T c.1179C>T(p.%3D) gaC/gaT chr17 7572930 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572930", "IGV") medium 0.133 2890 pass no call 8018 TP53_E00001757276_1 ENSG00000141510 11 of 11 61 FFPE TGTCA G/A TCTGA CMDL140019 FLD0098 FLD0122 nonsynonymous TP53 c.1138C>T p.H380Y Cat/Tat chr17 7572971 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572971", "IGV") low 0.183 2545 no call QD 3061 TP53_E00001757276_1 ENSG00000141510 11 of 11 tolerated(0.38) possibly_damaging(0.623) 40 FFPE TTTAT G/A GCGGG CMDL140019 FLD0098 FLD0122 synonymous TP53 c.1134C>T c.1134C>T(p.%3D) tcC/tcT chr17 7572975 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572975", "IGV") medium 0.253 2890 pass no call 9816 TP53_E00001757276_1 ENSG00000141510 11 of 11 36 FFPE TGGCG G/A GAGGT CMDL140019 FLD0098 FLD0122 nonsynonymous TP53 c.1130C>T p.T377I aCc/aTc chr17 7572979 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572979", "IGV") low 0.138 2890 QD no call 4063 TP53_E00001757276_1 ENSG00000141510 11 of 11 deleterious(0.04) possibly_damaging(0.548) 32 FFPE GGGAG G/A TAGAC CMDL140020 FLD0099 FLD0123 intron EGFR c.2284-53C>T chr7 55248933 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248933", "IGV") medium 0.162 1662 no call pass 7085 EGFR_E00001601336_1 ENSG00000146648 19 of 27 13 FFPE TGCCC C/T TCCTT CMDL140020 FLD0099 FLD0123 intron EGFR c.2284-47C>T chr7 55248939 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248939", "IGV") low 0.108 1662 no call QD 2549 EGFR_E00001601336_1 ENSG00000146648 19 of 27 19 FFPE TCCTT C/T TGGCC CMDL140020 FLD0099 FLD0123 intron EGFR c.2284-35C>T chr7 55248951 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248951", "IGV") low 0.086 1663 no call QD 1109 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs368090013 31 FFPE CCATG C/T GAAGC CMDL140020 FLD0099 FLD0123 intron EGFR c.2284-17C>T chr7 55248969 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248969", "IGV") low 0.138 3249 QD no call 393 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs750230492 49 FFPE ACGTG C/T CTCTC CMDL140020 FLD0099 FLD0123 nonsynonymous EGFR c.2288C>T p.A763V gCc/gTc chr7 55248990 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248990", "IGV") low 0.194 3249 QD no call 4413 EGFR_E00001601336_1 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(1) 70 FFPE GGAAG C/T CTACG CMDL140020 FLD0099 FLD0123 synonymous EGFR c.2292C>T c.2292C>T(p.%3D) taC/taT chr7 55248994 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248994", "IGV") medium 0.159 3249 pass no call 13065 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs755011268, COSM13401 74 FFPE GCCTA C/T GTGAT CMDL140020 FLD0099 FLD0123 synonymous EGFR c.2301C>T c.2301C>T(p.%3D) gcC/gcT chr7 55249003 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249003", "IGV") low 0.159 3249 QD no call 4035 EGFR_E00001601336_1 ENSG00000146648 20 of 28 83 FFPE ATGGC C/T AGCGT CMDL140020 FLD0099 FLD0123 synonymous EGFR c.2316C>T c.2316C>T(p.%3D) ccC/ccT chr7 55249018 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249018", "IGV") medium 0.323 3249 pass no call 25443 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs761020556, COSM13434, COSM12388 75 FFPE AACCC C/T CACGT CMDL140020 FLD0099 FLD0123 nonsynonymous EGFR c.2342G>A p.C781Y tGc/tAc chr7 55249044 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249044", "IGV") low 0.147 3249 QD no call 1028 EGFR_E00001601336_1 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(1) 49 FFPE CATCT G/A CCTCA CMDL140020 FLD0099 FLD0123 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.823 0.556 1554 1585 pass pass 49706 31706 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140020 FLD0099 FLD0123 nonsynonymous EGFR c.2384T>C p.F795S tTc/tCc chr7 55249086 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55249086", "IGV") medium 0.147 1554 pass no call 4585 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM22951 deleterious(0.01) possibly_damaging(0.86) 7 FFPE GCCCT T/C CGGCT CMDL140020 FLD0099 FLD0123 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.528 0.497 1705 1702 pass pass 33076 30581 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140020 FLD0099 FLD0123 nonsynonymous EGFR c.2614G>A p.E872K Gaa/Aaa chr7 55259556 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259556", "IGV") low 0.080 1126 QD no call 134 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM133589, COSM18487 deleterious(0) probably_damaging(0.947) 16 FFPE ATGCA G/A AAGGA CMDL140020 FLD0099 FLD0123 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.550 0.572 1608 1748 pass pass 32459 36835 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140020 FLD0099 FLD0123 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") medium 0.244 0.212 755 1046 pass QD 1978 1060 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL140020 FLD0099 FLD0123 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") medium 0.170 1046 no call pass 2565 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL140020 FLD0099 FLD0123 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.011 786 QD no call 639 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL140020 FLD0099 FLD0123 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.999 787 QD no call 639 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140020 FLD0099 FLD0123 nonsynonymous TP53 c.659A>G p.Y220C tAt/tGt chr17 7578190 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578190", "IGV") high 0.540 0.631 2182 2144 pass pass 25300 32241 TP53_E00001255919_1 25404506 ENSG00000141510 6 of 11 CM015378, CM951227, rs121912666, TP53_g.12728A>T, TP53_g.12728A>C, TP53_g.12728A>G, COSM10758, COSM43850, COSM1564197, COSM99720, COSM251427, COSM1564198, COSM251426, COSM99718, COSM1564199, COSM3355993, COSM3675523, COSM1644277, COSM3675522, COSM99719, COSM251428, COSM1564200 deleterious(0) probably_damaging(1) pathogenic 63 FFPE GCTCA T/C AGGGC CMDL140020 FLD0099 FLD0123 intron TP53 c.74+56C>T chr17 7579783 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579783", "IGV") low 0.117 1088 QD no call 1719 TP53_E00001596491_1 ENSG00000141510 2 of 10 6 FFPE TGCTA G/A GGGGC CMDL140020 FLD0099 FLD0123 intron TP53 c.74+47C>T chr17 7579792 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579792", "IGV") low 0.150 2180 QD no call 1542 TP53_E00001596491_1 ENSG00000141510 2 of 10 15 FFPE GCTGG G/A GTTGG CMDL140020 FLD0099 FLD0123 intron TP53 c.74+40C>T chr17 7579799 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579799", "IGV") low 0.158 2180 QD no call 4144 TP53_E00001596491_1 ENSG00000141510 2 of 10 22 FFPE TTGGG G/A TGGGG CMDL140020 FLD0099 FLD0123 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.853 0.737 2180 2463 pass pass 66990 59475 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140020 FLD0099 FLD0123 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") medium 0.156 2463 no call pass 9631 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL140020 FLD0099 FLD0123 intron TP53 c.74+36C>T chr17 7579803 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579803", "IGV") low 0.089 2180 QD no call 261 TP53_E00001596491_1 ENSG00000141510 2 of 10 26 FFPE GGTGG G/A GGTGG CMDL140020 FLD0099 FLD0123 intron TP53 c.74+35C>T chr17 7579804 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579804", "IGV") low 0.144 2180 QD no call 3604 TP53_E00001596491_1 ENSG00000141510 2 of 10 27 FFPE GTGGG G/A GTGGT CMDL140020 FLD0099 FLD0123 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") low 0.141 2463 no call QD 4472 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL140020 FLD0099 FLD0123 intron TP53 c.74+28C>T chr17 7579811 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579811", "IGV") medium 0.163 2463 no call pass 7593 TP53_E00001596491_1 ENSG00000141510 2 of 10 34 FFPE TGGTG G/A GCCTG CMDL140020 FLD0099 FLD0123 5_prime_UTR TP53 c.-6A>G chr17 7579918 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7579918", "IGV") low 0.086 1119 QD no call 326 TP53_E00001596491_1 ENSG00000141510 2 of 11 5 FFPE GGCAG T/C GACCC CMDL140020 FLD0099 FLD0123 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.950 0.904 1080 823 pass pass 33981 25683 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140020 FLD0099 FLD0123 3_prime_UTR TP53 c.*50C>T chr17 7572877 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572877", "IGV") low 0.103 1518 no call QD 1571 TP53_E00001757276_1 ENSG00000141510 11 of 11 8 FFPE GGGAG G/A GAGAG CMDL140020 FLD0099 FLD0123 3_prime_UTR TP53 c.*41C>T chr17 7572886 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572886", "IGV") low 0.120 2647 QD no call 200 TP53_E00001757276_1 ENSG00000141510 11 of 11 17 FFPE AGATG G/A GGGTG CMDL140020 FLD0099 FLD0123 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.152 0.325 2647 2726 QD pass 1728 15054 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140020 FLD0099 FLD0123 3_prime_UTR TP53 c.*36C>T chr17 7572891 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572891", "IGV") medium 0.209 2726 no call pass 6132 TP53_E00001757276_1 ENSG00000141510 11 of 11 22 FFPE GGGGT G/A GGAGG CMDL140020 FLD0099 FLD0123 synonymous TP53 c.1149C>T c.1149C>T(p.%3D) ctC/ctT chr17 7572960 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572960", "IGV") low 0.139 2726 no call QD 1138 TP53_E00001757276_1 ENSG00000141510 11 of 11 51 FFPE AACAT G/A AGTTT CMDL140046 FLD0100 FLD0124 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") medium 0.986 1077 no call pass 44560 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140046 FLD0100 FLD0124 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.989 0.998 1768 1547 pass pass 82476 74157 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140046 FLD0100 FLD0124 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.996 0.998 1829 1542 pass pass 77683 66716 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140046 FLD0100 FLD0124 intron TP53 c.97-48G>A chr17 7579638 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579638", "IGV") medium 0.198 361 no call pass 1466 EXP0116_TP53_E3 ENSG00000141510 3 of 10 62 FFPE GCCCC C/T CAGCC CMDL140046 FLD0100 FLD0124 stop_gained PIK3CA c.1655G>A p.W552* tGg/tAg chr3 178936113 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936113", "IGV") low 0.132 675 no call QD 1161 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 14 FFPE TCTAT G/A GAGTC CMDL140046 FLD0100 FLD0124 intron PTEN c.802-162C>T chr10 89720489 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720489", "IGV") medium 0.122 1091 no call pass 2436 PTEN_E00001156315_1m ENSG00000171862 7 of 8 9 FFPE ATAGT C/T TTTGT CMDL140046 FLD0100 FLD0124 intron PTEN c.802-82A>G chr10 89720569 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89720569", "IGV") medium 0.212 1146 no call pass 4304 PTEN_E00001156315_1m ENSG00000171862 7 of 8 89 FFPE GACAG A/G TTTTC CMDL140046 FLD0100 FLD0124 intron PTEN c.802-14T>C chr10 89720637 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720637", "IGV") low 0.027 77 QD no call 78 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs775342006 48 FFPE TCTTT T/C TTTTT CMDL140046 FLD0100 FLD0124 intron PTEN c.801+22G>A chr10 89717798 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717798", "IGV") medium 0.159 1233 no call pass 3748 PTEN_E00001156321_4m ENSG00000171862 7 of 8 29 FFPE CATTG G/A GAGAA CMDL140046 FLD0100 FLD0124 synonymous PTEN c.525G>A c.525G>A(p.%3D) gtG/gtA chr10 89711907 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89711907", "IGV") low 0.192 3341 QD no call 4553 PTEN_E00001156327_1 ENSG00000171862 6 of 9 11 FFPE TATGT G/A TATTA CMDL140046 FLD0100 FLD0124 nonsynonymous PTEN c.380G>A p.G127E gGa/gAa chr10 89692896 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692896", "IGV") low 0.089 1444 QD no call 613 PTEN_E00001156330_3 ENSG00000171862 5 of 9 rs398123322, COSM5285, COSM5143 deleterious(0.03) probably_damaging(0.96) uncertain_significance 33 FFPE AGCTG G/A AAAGG CMDL140046 FLD0100 FLD0124 nonsynonymous PTEN c.425G>A p.R142Q cGg/cAg chr10 89692941 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692941", "IGV") low 0.150 2853 QD no call 398 PTEN_E00001156330_3 ENSG00000171862 5 of 9 rs753630034, COSM30623, COSM5034, COSM1349539 tolerated(0.43) benign(0.111) 78 FFPE ACATC G/A GGGCA CMDL140046 FLD0100 FLD0124 nonsynonymous PTEN c.469G>A p.E157K Gaa/Aaa chr10 89692985 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692985", "IGV") low 0.142 2853 QD no call 65 PTEN_E00001156330_3 ENSG00000171862 5 of 9 rs121909220, CM971274, COSM921104, COSM1577254 tolerated(0.21) benign(0.115) pathogenic 40 FFPE ATGGG G/A AAGTA CMDL140046 FLD0100 FLD0124 nonsynonymous PTEN c.484G>A p.D162N Gac/Aac chr10 89693000 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89693000", "IGV") low 0.117 1414 QD no call 1972 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5274 tolerated(0.25) benign(0.313) 25 FFPE CCAGA G/A ACAAA CMDL140046 FLD0100 FLD0124 nonsynonymous PTEN c.88C>T p.P30S Cca/Tca chr10 89653790 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653790", "IGV") low 0.145 3762 QD no call 54 PTEN_E00001156351_1 ENSG00000171862 2 of 9 tolerated(0.08) benign(0.186) 23 FFPE TTTAT C/T CAAAC CMDL140046 FLD0100 FLD0124 synonymous PTEN c.144C>T c.144C>T(p.%3D) aaC/aaT chr10 89653846 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653846", "IGV") medium 0.361 3762 pass no call 20974 PTEN_E00001156351_1 ENSG00000171862 2 of 9 rs762518389, CM033665 51 FFPE AGGAA C/T AATAT CMDL140046 FLD0100 FLD0124 intron TP53 c.74+47C>T chr17 7579792 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579792", "IGV") medium 0.372 1688 pass no call 11203 TP53_E00001596491_1 ENSG00000141510 2 of 10 15 FFPE GCTGG G/A GTTGG CMDL140046 FLD0100 FLD0124 intron TP53 c.74+43C>T chr17 7579796 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579796", "IGV") medium 0.378 1688 pass no call 22132 TP53_E00001596491_1 ENSG00000141510 2 of 10 19 FFPE GGGTT G/A GGGTG CMDL140046 FLD0100 FLD0124 intron TP53 c.74+27C>T chr17 7579812 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579812", "IGV") low 0.175 1737 no call QD 2073 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs2307495 35 FFPE GGTGG G/A CCTGC CMDL140046 FLD0100 FLD0124 synonymous TP53 c.267C>T c.267C>T(p.%3D) ccC/ccT chr17 7579420 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579420", "IGV") low 0.099 263 no call QD 200 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs587783062, TP53_g.11498C>T, TP53_g.11498del, COSM1268330, COSM1180853, COSM1180854 likely_pathogenic 43 FFPE CAGGA G/A GGGGC CMDL140046 FLD0100 FLD0124 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") medium 0.185 0.257 236 263 QD pass 342 1271 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140046 FLD0100 FLD0124 nonsynonymous TP53 c.199C>T p.P67S Cca/Tca chr17 7579488 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579488", "IGV") low 0.093 236 QD no call 34 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11430C>T, TP53_g.11430del, COSM44199, COSM46345 tolerated(0.64) benign(0.001) 13 FFPE CTCTG G/A CATTC CMDL140046 FLD0100 FLD0124 3_prime_UTR TP53 c.*45C>T chr17 7572882 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572882", "IGV") low 0.090 2509 QD no call 2705 TP53_E00001757276_1 ENSG00000141510 11 of 11 13 FFPE GGAGA G/A ATGGG CMDL140046 FLD0100 FLD0124 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.093 0.180 2509 2386 QD pass 2705 5797 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140046 FLD0100 FLD0124 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.187 2386 no call QD 4700 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140046 FLD0100 FLD0124 3_prime_UTR TP53 c.*21C>T chr17 7572906 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572906", "IGV") low 0.149 2509 QD no call 1379 TP53_E00001757276_1 ENSG00000141510 11 of 11 37 FFPE CAGTG G/A GGAAC CMDL140062 FLD0101 FLD0125 intron EGFR c.2284-55C>T chr7 55248931 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248931", "IGV") low 0.113 1838 no call QD 2448 EGFR_E00001601336_1 ENSG00000146648 19 of 27 11 FFPE TGTGC C/T CCTCC CMDL140062 FLD0101 FLD0125 intron EGFR c.2284-54C>T chr7 55248932 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248932", "IGV") low 0.118 1838 no call QD 2855 EGFR_E00001601336_1 ENSG00000146648 19 of 27 12 FFPE GTGCC C/T CTCCT CMDL140062 FLD0101 FLD0125 intron EGFR c.2284-35C>T chr7 55248951 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248951", "IGV") low 0.122 1838 no call QD 3441 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs368090013 31 FFPE CCATG C/T GAAGC CMDL140062 FLD0101 FLD0125 splice_region,intron EGFR c.2284-8C>T chr7 55248978 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248978", "IGV") low 0.186 3583 no call QD 5114 EGFR_E00001601336_1 ENSG00000146648 19 of 27 58 FFPE TCCCT C/T CCTCC CMDL140062 FLD0101 FLD0125 nonsynonymous EGFR c.2360A>G p.Q787R cAg/cGg chr7 55249062 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55249062", "IGV") medium 0.124 1745 no call pass 4067 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM18422 deleterious(0) probably_damaging(1) 31 FFPE CGTGC A/G GCTCA CMDL140062 FLD0101 FLD0125 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.562 0.475 1649 1745 pass pass 33714 29895 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140062 FLD0101 FLD0125 synonymous EGFR c.2364C>T c.2364C>T(p.%3D) ctC/ctT chr7 55249066 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249066", "IGV") medium 0.116 1745 no call pass 3717 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs201469865 27 FFPE CAGCT C/T ATCAC CMDL140062 FLD0101 FLD0125 nonsynonymous EGFR c.2372A>T p.Q791L cAg/cTg chr7 55249074 A T =hyperlink("http://localhost:60151/goto?locus=chr7:55249074", "IGV") low 0.111 1745 no call QD 2933 EGFR_E00001601336_1 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(1) 19 FFPE CACGC A/T GCTCA CMDL140062 FLD0101 FLD0125 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.497 0.532 1701 1822 pass pass 30109 34530 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140062 FLD0101 FLD0125 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.455 0.397 1587 1759 pass pass 25224 23454 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140062 FLD0101 FLD0125 nonsynonymous KRAS c.35G>A p.G12D gGt/gAt chr12 25398284 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") high 0.532 0.553 3914 4310 pass pass 42216 51007 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) benign(0.361) 26 FFPE CGCCA C/T CAGCT CMDL140062 FLD0101 FLD0125 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.994 1535 no call pass 63955 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140062 FLD0101 FLD0125 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.104 1300 no call QD 1771 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL140062 FLD0101 FLD0125 intron TP53 c.74+47C>T chr17 7579792 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579792", "IGV") medium 0.145 2601 no call pass 6968 TP53_E00001596491_1 ENSG00000141510 2 of 10 15 FFPE GCTGG G/A GTTGG CMDL140062 FLD0101 FLD0125 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.590 0.620 2195 2601 pass pass 33509 46578 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140062 FLD0101 FLD0125 intron TP53 c.74+28C>T chr17 7579811 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579811", "IGV") low 0.095 2601 no call QD 2626 TP53_E00001596491_1 ENSG00000141510 2 of 10 34 FFPE TGGTG G/A GCCTG CMDL140062 FLD0101 FLD0125 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.850 0.805 1048 1091 pass pass 24365 23485 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140062 FLD0101 FLD0125 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.139 3240 QD no call 848 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140062 FLD0101 FLD0125 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.129 3240 QD no call 372 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140134 FLD0102 FLD0126 nonsynonymous BRAF c.1799T>A p.V600E gTg/gAg chr7 140453136 A T =hyperlink("http://localhost:60151/goto?locus=chr7:140453136", "IGV") high 0.413 0.355 3668 4209 pass pass 27436 23451 BRAF_AA_HS ENSG00000157764 15 of 18 CM112509, COSM476, COSM6137, COSM18443 deleterious(0) probably_damaging(0.967) 10 FFPE ATTTC A/T CTGTA CMDL140134 FLD0102 FLD0126 intron EGFR c.2284-27C>T chr7 55248959 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248959", "IGV") medium 0.239 670 pass no call 13948 EGFR_E00001601336_1 ENSG00000146648 19 of 27 39 FFPE AGCCA C/T ACTGA CMDL140134 FLD0102 FLD0126 synonymous EGFR c.2313C>T c.2313C>T(p.%3D) aaC/aaT chr7 55249015 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249015", "IGV") medium 0.240 2182 pass no call 10799 EGFR_E00001601336_1 ENSG00000146648 20 of 28 78 FFPE GACAA C/T CCCCA CMDL140134 FLD0102 FLD0126 synonymous EGFR c.2319C>T c.2319C>T(p.%3D) caC/caT chr7 55249021 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249021", "IGV") medium 0.241 2182 pass no call 8173 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs768468531 72 FFPE CCCCA C/T GTGTG CMDL140134 FLD0102 FLD0126 synonymous EGFR c.2355C>T c.2355C>T(p.%3D) acC/acT chr7 55249057 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249057", "IGV") medium 0.241 1529 pass no call 10631 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs148188503, COSM1451599 likely_benign 36 FFPE TCCAC C/T GTGCA CMDL140134 FLD0102 FLD0126 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") medium 0.748 1.000 1529 2 pass pass 43753 55 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140134 FLD0102 FLD0126 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.411 0.441 1470 1711 pass pass 22045 26224 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140134 FLD0102 FLD0126 splice_donor EGFR c.2469+1G>A chr7 55249172 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249172", "IGV") low 0.091 1385 QD no call 705 EGFR_E00001601336_2 ENSG00000146648 20 of 27 23 FFPE CAAAG G/A TAATC CMDL140134 FLD0102 FLD0126 intron EGFR c.2626-48G>A chr7 55260411 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260411", "IGV") low 0.082 2045 no call QD 270 EGFR_E00001631695_1 ENSG00000146648 21 of 27 24 FFPE CAACA G/A AGGGA CMDL140134 FLD0102 FLD0126 nonsynonymous EGFR c.2686G>A p.D896N Gat/Aat chr7 55260519 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260519", "IGV") low 0.079 2042 no call QD 57 EGFR_E00001631695_1 ENSG00000146648 22 of 28 deleterious(0.01) probably_damaging(1) 34 FFPE AGAGT G/A ATGTC CMDL140134 FLD0102 FLD0126 synonymous EGFR c.2487G>A c.2487G>A(p.%3D) gaG/gaA chr7 55259429 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259429", "IGV") low 0.089 993 QD no call 650 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs41420046, COSM24845 A:0.0036 13 FFPE TTGGA G/A GACCG CMDL140134 FLD0102 FLD0126 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.997 0.972 1683 1696 pass pass 72401 71344 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140134 FLD0102 FLD0126 intron TP53 c.97-32G>A chr17 7579622 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579622", "IGV") medium 0.841 1185 pass no call 26948 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs754228616 46 FFPE GAGGA C/T CAGGT CMDL140134 FLD0102 FLD0126 intron TP53 c.96+23G>A chr17 7579677 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579677", "IGV") medium 0.877 1185 pass no call 26196 EXP0116_TP53_E3 ENSG00000141510 3 of 10 58 FFPE AGGTC C/T CCAGC CMDL140134 FLD0102 FLD0126 intron PTEN c.802-135C>T chr10 89720516 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720516", "IGV") low 0.150 1107 QD no call 2177 PTEN_E00001156315_1m ENSG00000171862 7 of 8 36 FFPE AATAT C/T AAATG CMDL140134 FLD0102 FLD0126 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.008 72 LowQual,QD no call 15 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL140134 FLD0102 FLD0126 nonsynonymous PTEN c.895G>A p.E299K Gaa/Aaa chr10 89720744 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720744", "IGV") low 0.090 2115 QD no call 748 PTEN_E00001156315_7 ENSG00000171862 8 of 9 CM110151, COSM5312 tolerated(0.22) benign(0.012) 12 FFPE ATCAA G/A AAATC CMDL140134 FLD0102 FLD0126 synonymous PTEN c.477G>A c.477G>A(p.%3D) agG/agA chr10 89692993 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692993", "IGV") low 0.105 1466 no call QD 1326 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5287 32 FFPE GTAAG G/A ACCAG CMDL140134 FLD0102 FLD0126 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.542 1341 pass no call 25577 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140134 FLD0102 FLD0126 synonymous TP53 c.489C>T c.489C>T(p.%3D) taC/taT chr17 7578441 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578441", "IGV") low 0.118 3050 no call QD 5553 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12477del, TP53_g.12477C>T, TP53_g.12477C>A, TP53_g.12477C>G, COSM43820, COSM45411, COSM44391, COSM45810, COSM3701299, COSM3701302, COSM3701304, COSM3701301, COSM3701300, COSM3701303 63 FFPE TGCTT G/A TAGAT CMDL140134 FLD0102 FLD0126 synonymous TP53 c.477C>T c.477C>T(p.%3D) gcC/gcT chr17 7578453 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578453", "IGV") low 0.118 3050 no call QD 1161 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12465C>T, TP53_g.12465del, COSM44130 56 FFPE GCCAT G/A GCGCG CMDL140134 FLD0102 FLD0126 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") medium 0.122 1226 pass no call 3086 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL140134 FLD0102 FLD0126 intron TP53 c.74+53C>T chr17 7579786 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579786", "IGV") medium 0.125 1227 pass no call 3114 TP53_E00001596491_1 ENSG00000141510 2 of 10 9 FFPE TAGGG G/A GCTGG CMDL140134 FLD0102 FLD0126 intron TP53 c.74+46C>T chr17 7579793 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579793", "IGV") medium 0.108 2300 no call pass 4706 TP53_E00001596491_1 ENSG00000141510 2 of 10 16 FFPE CTGGG G/A TTGGG CMDL140134 FLD0102 FLD0126 intron TP53 c.74+43C>T chr17 7579796 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579796", "IGV") low 0.128 2300 no call QD 407 TP53_E00001596491_1 ENSG00000141510 2 of 10 19 FFPE GGGTT G/A GGGTG CMDL140134 FLD0102 FLD0126 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.528 0.774 2402 2300 pass pass 40719 56272 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140134 FLD0102 FLD0126 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") low 0.150 2402 QD no call 1542 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL140134 FLD0102 FLD0126 intron TP53 c.74+36C>T chr17 7579803 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579803", "IGV") medium 0.174 0.125 2402 2300 pass QD 5421 2859 TP53_E00001596491_1 ENSG00000141510 2 of 10 26 FFPE GGTGG G/A GGTGG CMDL140134 FLD0102 FLD0126 intron TP53 c.74+35C>T chr17 7579804 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579804", "IGV") medium 0.109 2300 no call pass 4706 TP53_E00001596491_1 ENSG00000141510 2 of 10 27 FFPE GTGGG G/A GTGGT CMDL140134 FLD0102 FLD0126 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") medium 0.167 0.319 2402 2300 QD pass 3618 10858 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL140134 FLD0102 FLD0126 intron TP53 c.74+31C>T chr17 7579808 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579808", "IGV") medium 0.229 2402 pass no call 11248 TP53_E00001596491_1 ENSG00000141510 2 of 10 31 FFPE GGGTG G/A TGGGC CMDL140134 FLD0102 FLD0126 splice_region,synonymous TP53 c.73C>T c.73C>T(p.%3D) Cta/Tta chr17 7579840 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579840", "IGV") low 0.139 2402 QD no call 1040 TP53_E00001596491_1 ENSG00000141510 2 of 11 63 FFPE TCACA G/A TTTCC CMDL140134 FLD0102 FLD0126 synonymous TP53 c.30C>T c.30C>T(p.%3D) gtC/gtT chr17 7579883 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579883", "IGV") high 0.138 0.293 2402 2300 pass pass 7288 9293 TP53_E00001596491_1 ENSG00000141510 2 of 11 TP53_g.11035C>T, COSM984987, COSM984988, COSM984990, COSM984991 40 FFPE GGCTC G/A ACGCT CMDL140134 FLD0102 FLD0126 nonsynonymous TP53 c.8A>G p.E3G gAg/gGg chr17 7579905 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7579905", "IGV") medium 0.138 2401 pass no call 7288 TP53_E00001596491_1 ENSG00000141510 2 of 11 deleterious(0) possibly_damaging(0.548) 18 FFPE GCGGC T/C CCTCC CMDL140134 FLD0102 FLD0126 nonsynonymous TP53 c.296C>T p.S99F tCc/tTc chr17 7579391 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579391", "IGV") low 0.108 357 QD no call 258 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11527C>T, COSM44036 deleterious(0.01) probably_damaging(0.978) 14 FFPE TCTGG G/A AAGGG CMDL140134 FLD0102 FLD0126 nonsynonymous TP53 c.251C>T p.A84V gCc/gTc chr17 7579436 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579436", "IGV") low 0.097 357 QD no call 211 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11482C>G, TP53_g.11482C>T, COSM44075, COSM44194 tolerated(0.31) benign(0.023) 59 FFPE CAGGG G/A CCGCC CMDL140134 FLD0102 FLD0126 nonsynonymous TP53 c.236C>T p.A79V gCt/gTt chr17 7579451 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579451", "IGV") low 0.078 357 QD no call 202 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11467C>T, TP53_g.11467C>G, COSM1386917, COSM45590, COSM1386920, COSM1386918, COSM1386921, COSM1386919 tolerated(0.29) benign(0.009) 50 FFPE TAGGA G/A CTGCT CMDL140134 FLD0102 FLD0126 synonymous TP53 c.216C>T c.216C>T(p.%3D) ccC/ccT chr17 7579471 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579471", "IGV") low 0.078 357 QD no call 202 TP53_E00001612188_2 ENSG00000141510 4 of 11 COSM18569, COSM1268331, COSM1268332 30 FFPE GCCAC G/A GGGGG CMDL140134 FLD0102 FLD0126 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.871 0.827 357 380 pass pass 10200 8351 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140134 FLD0102 FLD0126 synonymous TP53 c.213C>T c.213C>T(p.%3D) ccC/ccT chr17 7579474 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579474", "IGV") low 0.090 357 QD no call 230 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11444C>T 27 FFPE ACGGG G/A GGAGC CMDL140134 FLD0102 FLD0126 synonymous TP53 c.690C>T c.690C>T(p.%3D) acC/acT chr17 7577591 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577591", "IGV") low 0.088 1619 no call QD 698 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13327C>A, TP53_g.13327C>T, COSM43866 21 FFPE ATGGT G/A GTACA CMDL140134 FLD0102 FLD0126 3_prime_UTR TP53 c.*51C>T chr17 7572876 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572876", "IGV") low 0.097 1407 QD no call 1899 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs760698953 7 FFPE GGGGA G/A GGAGA CMDL140134 FLD0102 FLD0126 3_prime_UTR TP53 c.*49C>T chr17 7572878 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572878", "IGV") low 0.083 1414 QD no call 200 TP53_E00001757276_1 ENSG00000141510 11 of 11 9 FFPE GGAGG G/A AGAGA CMDL140134 FLD0102 FLD0126 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.181 2971 QD no call 5096 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140134 FLD0102 FLD0126 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") medium 0.300 2725 no call pass 12494 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL140134 FLD0102 FLD0126 3_prime_UTR TP53 c.*36C>T chr17 7572891 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572891", "IGV") low 0.070 2971 QD no call 52 TP53_E00001757276_1 ENSG00000141510 11 of 11 22 FFPE GGGGT G/A GGAGG CMDL140134 FLD0102 FLD0126 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") low 0.141 2725 no call QD 238 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL140134 FLD0102 FLD0126 3_prime_UTR TP53 c.*20C>T chr17 7572907 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572907", "IGV") low 0.158 2725 no call QD 4295 TP53_E00001757276_1 ENSG00000141510 11 of 11 38 FFPE AGTGG G/A GAACA CMDL140134 FLD0102 FLD0126 3_prime_UTR TP53 c.*5C>T chr17 7572922 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572922", "IGV") low 0.176 2971 QD no call 3824 TP53_E00001757276_1 ENSG00000141510 11 of 11 53 FFPE GTGGA G/A AATGT CMDL140134 FLD0102 FLD0126 synonymous TP53 c.1155C>T c.1155C>T(p.%3D) ttC/ttT chr17 7572954 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572954", "IGV") low 0.148 2725 no call QD 1805 TP53_E00001757276_1 ENSG00000141510 11 of 11 57 FFPE GTCTT G/A AACAT CMDL140134 FLD0102 FLD0126 nonsynonymous TP53 c.1130C>T p.T377I aCc/aTc chr17 7572979 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572979", "IGV") low 0.138 2725 no call QD 799 TP53_E00001757276_1 ENSG00000141510 11 of 11 deleterious(0.04) possibly_damaging(0.548) 32 FFPE GGGAG G/A TAGAC CMDL140134 FLD0102 FLD0126 nonsynonymous TP53 c.1127C>T p.S376F tCt/tTt chr17 7572982 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572982", "IGV") medium 0.139 2725 no call pass 7089 TP53_E00001757276_1 ENSG00000141510 11 of 11 deleterious(0.01) possibly_damaging(0.895) 29 FFPE AGGTA G/A ACTGA CMDL140161 FLD0103 FLD0127 intron EGFR c.2284-56C>T chr7 55248930 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248930", "IGV") low 0.125 1864 no call QD 3482 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs41323247 T:0.0038 10 FFPE ATGTG C/T CCCTC CMDL140161 FLD0103 FLD0127 intron EGFR c.2284-39C>T chr7 55248947 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248947", "IGV") medium 0.319 1480 pass no call 17279 EGFR_E00001601336_1 ENSG00000146648 19 of 27 27 FFPE GCCAC C/T ATGCG CMDL140161 FLD0103 FLD0127 intron EGFR c.2284-25C>T chr7 55248961 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248961", "IGV") medium 0.315 1509 pass no call 23575 EGFR_E00001601336_1 ENSG00000146648 19 of 27 41 FFPE CCACA C/T TGACG CMDL140161 FLD0103 FLD0127 intron EGFR c.2284-10C>T chr7 55248976 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248976", "IGV") medium 0.316 2988 pass no call 21136 EGFR_E00001601336_1 ENSG00000146648 19 of 27 56 FFPE TCTCC C/T TCCCT CMDL140161 FLD0103 FLD0127 synonymous EGFR c.2349C>T c.2349C>T(p.%3D) acC/acT chr7 55249051 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249051", "IGV") low 0.163 2987 QD no call 1518 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs397517122 likely_benign 42 FFPE CTCAC C/T TCCAC CMDL140161 FLD0103 FLD0127 nonsynonymous KRAS c.35G>A p.G12D gGt/gAt chr12 25398284 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") high 0.429 0.401 3585 4527 pass pass 29507 32334 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) benign(0.361) 26 FFPE CGCCA C/T CAGCT CMDL140161 FLD0103 FLD0127 nonsynonymous PIK3CA c.1658G>A p.S553N aGt/aAt chr3 178936116 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936116", "IGV") medium 0.178 679 pass no call 2666 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM29106, COSM1666661 tolerated(0.1) benign(0.068) 11 FFPE ATGGA G/A TCACA CMDL140161 FLD0103 FLD0127 intron PTEN c.802-135C>T chr10 89720516 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720516", "IGV") low 0.094 1316 no call QD 1302 PTEN_E00001156315_1m ENSG00000171862 7 of 8 36 FFPE AATAT C/T AAATG CMDL140161 FLD0103 FLD0127 intron PTEN c.802-12T>C chr10 89720639 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720639", "IGV") low 0.036 227 no call QD 374 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs587781129 benign 46 FFPE TTTTT T/C TTTTT CMDL140161 FLD0103 FLD0127 intron PTEN c.802-11T>C chr10 89720640 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720640", "IGV") medium 0.042 227 no call pass 852 PTEN_E00001156315_1m ENSG00000171862 7 of 8 45 FFPE TTTTT T/C TTTTT CMDL140161 FLD0103 FLD0127 intron PTEN c.802-9T>C chr10 89720642 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720642", "IGV") medium 0.039 227 no call pass 1335 PTEN_E00001156315_1m ENSG00000171862 7 of 8 43 FFPE TTTTT T/C TTTTT CMDL140161 FLD0103 FLD0127 intron PTEN c.801+138G>A chr10 89717914 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717914", "IGV") low 0.083 1460 QD no call 419 PTEN_E00001156321_4m ENSG00000171862 7 of 8 20 FFPE TTGGT G/A AGACA CMDL140161 FLD0103 FLD0127 splice_donor PTEN c.492+1G>A chr10 89693009 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89693009", "IGV") low 0.081 1328 QD no call 37 PTEN_E00001156330_3 ENSG00000171862 5 of 8 CD020869, COSM5973 16 FFPE AAAAG G/A TAAGT CMDL140161 FLD0103 FLD0127 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") medium 0.216 1203 pass no call 6120 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL140161 FLD0103 FLD0127 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.998 0.998 2425 2623 pass pass 89897 95947 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140161 FLD0103 FLD0127 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") low 0.133 2425 QD no call 636 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL140161 FLD0103 FLD0127 intron TP53 c.74+11C>T chr17 7579828 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579828", "IGV") low 0.124 2425 QD no call 236 TP53_E00001596491_1 ENSG00000141510 2 of 10 51 FFPE CAATG G/A ATCCA CMDL140161 FLD0103 FLD0127 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.990 0.998 779 959 pass pass 25199 31211 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140161 FLD0103 FLD0127 3_prime_UTR TP53 c.*49C>T chr17 7572878 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572878", "IGV") low 0.119 1403 QD no call 2146 TP53_E00001757276_1 ENSG00000141510 11 of 11 9 FFPE GGAGG G/A AGAGA CMDL140161 FLD0103 FLD0127 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.252 3348 no call pass 13856 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140161 FLD0103 FLD0127 3_prime_UTR TP53 c.*19C>T chr17 7572908 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572908", "IGV") low 0.143 2828 QD no call 377 TP53_E00001757276_1 ENSG00000141510 11 of 11 39 FFPE GTGGG G/A AACAA CMDL140168 FLD0104 FLD0128 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.765 0.795 1460 1976 pass pass 43441 60949 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140168 FLD0104 FLD0128 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.747 0.770 1382 1766 pass pass 42218 58447 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140168 FLD0104 FLD0128 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.704 0.763 1451 1807 pass pass 38873 53689 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140168 FLD0104 FLD0128 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.107 617 QD no call 173 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL140168 FLD0104 FLD0128 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.002 948 QD no call 299 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL140168 FLD0104 FLD0128 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.998 948 QD no call 299 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140168 FLD0104 FLD0128 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.993 0.995 1903 2506 pass pass 67090 85552 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140168 FLD0104 FLD0128 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.987 0.993 1031 1461 pass pass 32329 44655 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140168 FLD0104 FLD0128 nonsynonymous TP53 c.1009C>T p.R337C Cgc/Tgc chr17 7574018 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7574018", "IGV") high 0.478 0.520 1066 1399 pass pass 17933 26158 TP53_E00001728015_1 ENSG00000141510 10 of 11 rs587782529, CM981929, TP53_g.16900C>T, COSM11071, COSM1563605, COSM235697, COSM111628, COSM117591, COSM1563606, COSM111629 tolerated(0.09) benign(0.344) pathogenic 19 FFPE GAAGC G/A CTCAC CMDL140168 FLD0104 FLD0128 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") low 0.123 2092 QD no call 1049 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL150017 FLD0105 FLD0129 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.493 0.517 1748 1958 pass pass 29759 35954 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150017 FLD0105 FLD0129 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.487 0.529 1577 1762 pass pass 26462 33856 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150017 FLD0105 FLD0129 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.503 0.479 1559 1790 pass pass 27996 30655 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150017 FLD0105 FLD0129 intron TP53 c.96+21G>A chr17 7579679 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579679", "IGV") low 0.069 1114 no call QD 270 EXP0116_TP53_E3 ENSG00000141510 3 of 10 56 FFPE GTCCC C/T AGCCC CMDL150017 FLD0105 FLD0129 nonsynonymous PIK3CA c.3140A>G p.H1047R cAt/cGt chr3 178952085 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178952085", "IGV") high 0.536 0.521 3009 3495 pass pass 32910 37558 PIK3CA_Exn21_gap 25710561 ENSG00000121879 21 of 21 rs121913279, COSM776, COSM775, COSM249874, COSM94987, COSM94986 tolerated(0.11) possibly_damaging(0.529) pathogenic 28 FFPE TGCAC A/G TCATG CMDL150017 FLD0105 FLD0129 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.013 112 QD no call 35 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150017 FLD0105 FLD0129 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.996 0.992 2232 2158 pass pass 77222 73038 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150017 FLD0105 FLD0129 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.988 0.992 1058 1672 pass pass 32965 53230 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150030 FLD0106 FLD0130 intron EGFR c.2284-30C>T chr7 55248956 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248956", "IGV") medium 0.439 1534 pass no call 23319 EGFR_E00001601336_1 ENSG00000146648 19 of 27 36 FFPE CGAAG C/T CACAC CMDL150030 FLD0106 FLD0130 splice_acceptor EGFR c.2284-1G>A chr7 55248985 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55248985", "IGV") medium 0.257 3000 pass no call 8505 EGFR_E00001601336_1 ENSG00000146648 19 of 27 65 FFPE CTCCA G/A GAAGC CMDL150030 FLD0106 FLD0130 synonymous EGFR c.2337C>T c.2337C>T(p.%3D) ggC/ggT chr7 55249039 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249039", "IGV") medium 0.439 3000 pass no call 23283 EGFR_E00001601336_1 ENSG00000146648 20 of 28 54 FFPE CTGGG C/T ATCTG CMDL150030 FLD0106 FLD0130 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.643 0.480 1913 1425 pass pass 46295 23955 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150030 FLD0106 FLD0130 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") high 0.866 0.190 1327 1374 pass pass 29763 3783 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL150030 FLD0106 FLD0130 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") medium 0.611 1327 pass no call 32457 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL150030 FLD0106 FLD0130 intron TP53 c.97-48G>A chr17 7579638 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579638", "IGV") medium 0.609 1327 pass no call 32901 EXP0116_TP53_E3 ENSG00000141510 3 of 10 62 FFPE GCCCC C/T CAGCC CMDL150030 FLD0106 FLD0130 intron TP53 c.97-49G>A chr17 7579639 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579639", "IGV") medium 0.610 1327 pass no call 32978 EXP0116_TP53_E3 ENSG00000141510 3 of 10 63 FFPE CCCCC C/T AGCCC CMDL150030 FLD0106 FLD0130 intron TP53 c.96+22G>A chr17 7579678 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579678", "IGV") medium 0.762 1374 no call pass 13779 EXP0116_TP53_E3 ENSG00000141510 3 of 10 57 FFPE GGTCC C/T CAGCC CMDL150030 FLD0106 FLD0130 intron TP53 c.96+13G>A chr17 7579687 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579687", "IGV") medium 0.151 1328 pass no call 6055 EXP0116_TP53_E3 ENSG00000141510 3 of 10 48 FFPE CCCAA C/T CCTTG CMDL150030 FLD0106 FLD0130 intron TP53 c.96+11G>A chr17 7579689 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579689", "IGV") medium 0.621 1328 pass no call 20438 EXP0116_TP53_E3 ENSG00000141510 3 of 10 46 FFPE CAACC C/T TTGTC CMDL150030 FLD0106 FLD0130 intron PTEN c.802-119T>C chr10 89720532 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720532", "IGV") medium 0.165 1298 pass no call 5128 PTEN_E00001156315_1m ENSG00000171862 7 of 8 52 FFPE TTATT T/C TGTTG CMDL150030 FLD0106 FLD0130 intron PTEN c.802-112C>T chr10 89720539 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720539", "IGV") medium 0.164 0.122 1298 1191 pass QD 5162 1952 PTEN_E00001156315_1m ENSG00000171862 7 of 8 59 FFPE GTTGA C/T TTTTT CMDL150030 FLD0106 FLD0130 intron PTEN c.802-76T>C chr10 89720575 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720575", "IGV") medium 0.174 1496 pass no call 3312 PTEN_E00001156315_1m ENSG00000171862 7 of 8 95 FFPE TTTTC T/C TTTTT CMDL150030 FLD0106 FLD0130 intron PTEN c.802-29C>T chr10 89720622 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720622", "IGV") low 0.270 109 no call QD 53 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs759473017, COSM5917 63 FFPE CATTT C/T TTTTT CMDL150030 FLD0106 FLD0130 intron PTEN c.802-14T>C chr10 89720637 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720637", "IGV") low 0.078 199 QD no call 387 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs775342006 48 FFPE TCTTT T/C TTTTT CMDL150030 FLD0106 FLD0130 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") medium 0.060 0.018 199 109 pass QD 993 169 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150030 FLD0106 FLD0130 intron PTEN c.801+127C>T chr10 89717903 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717903", "IGV") low 0.086 1501 no call QD 523 PTEN_E00001156321_4m ENSG00000171862 7 of 8 31 FFPE TTACT C/T TGGCA CMDL150030 FLD0106 FLD0130 intron PTEN c.801+130G>A chr10 89717906 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717906", "IGV") medium 0.187 1650 pass no call 6879 PTEN_E00001156321_4m ENSG00000171862 7 of 8 28 FFPE CTCTG G/A CATTG CMDL150030 FLD0106 FLD0130 intron PTEN c.801+138G>A chr10 89717914 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717914", "IGV") low 0.104 1650 QD no call 1747 PTEN_E00001156321_4m ENSG00000171862 7 of 8 20 FFPE TTGGT G/A AGACA CMDL150030 FLD0106 FLD0130 intron PTEN c.801+151G>A chr10 89717927 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717927", "IGV") low 0.098 1650 QD no call 1032 PTEN_E00001156321_4m ENSG00000171862 7 of 8 7 FFPE ATAAG G/A GTAAA CMDL150030 FLD0106 FLD0130 nonsynonymous PTEN c.362C>T p.A121V gCa/gTa chr10 89692878 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692878", "IGV") low 0.095 1382 no call QD 887 PTEN_E00001156330_3 ENSG00000171862 5 of 9 rs121909237, COSM5273 tolerated(0.42) possibly_damaging(0.669) pathogenic 15 FFPE TGCAG C/T AATTC CMDL150030 FLD0106 FLD0130 synonymous PTEN c.111T>C c.111T>C(p.%3D) ttT/ttC chr10 89653813 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89653813", "IGV") low 0.086 3293 no call QD 1532 PTEN_E00001156351_1 ENSG00000171862 2 of 9 46 FFPE GGATT T/C CCTGC CMDL150030 FLD0106 FLD0130 intron PTEN c.164+26C>T chr10 89653892 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653892", "IGV") low 0.078 1889 QD no call 124 PTEN_E00001156351_1 ENSG00000171862 2 of 8 rs764400570 5 FFPE TATTT C/T AAATA CMDL150030 FLD0106 FLD0130 intron TP53 c.74+52C>T chr17 7579787 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579787", "IGV") medium 0.154 893 pass no call 2682 TP53_E00001596491_1 ENSG00000141510 2 of 10 10 FFPE AGGGG G/A CTGGG CMDL150030 FLD0106 FLD0130 intron TP53 c.74+42C>T chr17 7579797 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579797", "IGV") low 0.152 2081 no call QD 1499 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs767153311 20 FFPE GGTTG G/A GGTGG CMDL150030 FLD0106 FLD0130 intron TP53 c.74+40C>T chr17 7579799 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579799", "IGV") low 0.189 1767 QD no call 3200 TP53_E00001596491_1 ENSG00000141510 2 of 10 22 FFPE TTGGG G/A TGGGG CMDL150030 FLD0106 FLD0130 intron TP53 c.74+38C>T chr17 7579801 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") low 0.070 2081 no call QD 94 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/A GGGGT CMDL150030 FLD0106 FLD0130 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") medium 0.480 2081 no call pass 25844 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL150030 FLD0106 FLD0130 intron TP53 c.74+36C>T chr17 7579803 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579803", "IGV") low 0.130 2081 no call QD 399 TP53_E00001596491_1 ENSG00000141510 2 of 10 26 FFPE GGTGG G/A GGTGG CMDL150030 FLD0106 FLD0130 intron TP53 c.74+35C>T chr17 7579804 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579804", "IGV") low 0.196 1767 QD no call 3288 TP53_E00001596491_1 ENSG00000141510 2 of 10 27 FFPE GTGGG G/A GTGGT CMDL150030 FLD0106 FLD0130 intron TP53 c.74+29C>T chr17 7579810 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579810", "IGV") low 0.158 1767 QD no call 1881 TP53_E00001596491_1 ENSG00000141510 2 of 10 33 FFPE GTGGT G/A GGCCT CMDL150030 FLD0106 FLD0130 nonsynonymous TP53 c.35C>T p.P12L cCc/cTc chr17 7579878 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579878", "IGV") medium 0.120 2081 no call pass 4732 TP53_E00001596491_1 ENSG00000141510 2 of 11 tolerated(0.57) benign(0.075) 45 FFPE GAGGG G/A GCTCG CMDL150030 FLD0106 FLD0130 nonsynonymous TP53 c.34C>T p.P12S Ccc/Tcc chr17 7579879 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579879", "IGV") medium 0.120 2081 no call pass 4732 TP53_E00001596491_1 ENSG00000141510 2 of 11 tolerated(0.51) possibly_damaging(0.864) 44 FFPE AGGGG G/A CTCGA CMDL150030 FLD0106 FLD0130 3_prime_UTR TP53 c.*51C>T chr17 7572876 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572876", "IGV") medium 0.130 1535 pass no call 4082 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs760698953 7 FFPE GGGGA G/A GGAGA CMDL150030 FLD0106 FLD0130 3_prime_UTR TP53 c.*50C>T chr17 7572877 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572877", "IGV") low 0.090 1537 QD no call 866 TP53_E00001757276_1 ENSG00000141510 11 of 11 8 FFPE GGGAG G/A GAGAG CMDL150030 FLD0106 FLD0130 3_prime_UTR TP53 c.*49C>T chr17 7572878 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572878", "IGV") low 0.125 1290 no call QD 2293 TP53_E00001757276_1 ENSG00000141510 11 of 11 9 FFPE GGAGG G/A AGAGA CMDL150030 FLD0106 FLD0130 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.155 3189 QD no call 3002 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150030 FLD0106 FLD0130 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.125 3189 QD no call 1348 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150030 FLD0106 FLD0130 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") low 0.141 3189 QD no call 1611 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL150032 FLD0107 FLD0131 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.325 0.501 1800 1812 pass pass 18443 32495 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150032 FLD0107 FLD0131 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.530 0.535 1551 1681 pass pass 30870 33330 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150032 FLD0107 FLD0131 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.519 0.535 1584 1570 pass pass 29947 30275 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150032 FLD0107 FLD0131 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.521 0.502 3794 3753 pass pass 39258 37086 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150032 FLD0107 FLD0131 intron TP53 c.97-25G>A chr17 7579615 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579615", "IGV") low 0.109 944 no call QD 968 EXP0116_TP53_E3 ENSG00000141510 3 of 10 39 FFPE GCAGT C/T AGAGG CMDL150032 FLD0107 FLD0131 intron TP53 c.97-48G>A chr17 7579638 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579638", "IGV") low 0.194 1216 QD no call 1128 EXP0116_TP53_E3 ENSG00000141510 3 of 10 62 FFPE GCCCC C/T CAGCC CMDL150032 FLD0107 FLD0131 intron TP53 c.97-49G>A chr17 7579639 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579639", "IGV") medium 0.127 944 no call pass 3185 EXP0116_TP53_E3 ENSG00000141510 3 of 10 63 FFPE CCCCC C/T AGCCC CMDL150032 FLD0107 FLD0131 nonsynonymous KRAS c.35G>T p.G12V gGt/gTt chr12 25398284 C A =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") high 0.371 0.366 3769 3721 pass pass 21192 22458 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) possibly_damaging(0.479) 26 FFPE CGCCA C/A CAGCT CMDL150032 FLD0107 FLD0131 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.013 79 no call LowQual,QD 12 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150032 FLD0107 FLD0131 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.726 1333 pass no call 35859 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150032 FLD0107 FLD0131 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.769 0.862 2379 2133 pass pass 50985 52447 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150032 FLD0107 FLD0131 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.949 0.942 1152 1106 pass pass 33883 29927 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150032 FLD0107 FLD0131 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.139 0.170 2733 2949 QD QD 516 2034 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150032 FLD0107 FLD0131 nonsynonymous TP53 c.817C>T p.R273C Cgt/Tgt chr17 7577121 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577121", "IGV") high 0.521 0.570 2419 2934 pass pass 24684 37381 TP53_E00001789298_3 ENSG00000141510 8 of 11 CM951233, CM010473, rs121913343, CM010471, TP53_g.13797C>G, TP53_g.13797del, TP53_g.13797C>T, TP53_g.13797C>A, COSM43909, COSM44701, COSM10659, COSM43843, COSM417971, COSM99933, COSM3719990, COSM3355991, COSM3958802, COSM3719992, COSM1645518, COSM3719991, COSM3958801 deleterious(0) probably_damaging(0.998) uncertain_significance,pathogenic 46 FFPE AACAC G/A CACCT CMDL150033 FLD0108 FLD0132 intron EGFR c.2284-56C>T chr7 55248930 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248930", "IGV") low 0.068 1262 no call QD 130 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs41323247 T:0.0038 10 FFPE ATGTG C/T CCCTC CMDL150033 FLD0108 FLD0132 intron EGFR c.2284-29C>T chr7 55248957 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248957", "IGV") medium 0.113 1400 pass no call 2896 EGFR_E00001601336_1 ENSG00000146648 19 of 27 37 FFPE GAAGC C/T ACACT CMDL150033 FLD0108 FLD0132 synonymous EGFR c.2316C>T c.2316C>T(p.%3D) ccC/ccT chr7 55249018 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249018", "IGV") low 0.162 2637 no call QD 2378 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs761020556, COSM13434, COSM12388 75 FFPE AACCC C/T CACGT CMDL150033 FLD0108 FLD0132 synonymous EGFR c.2332C>T c.2332C>T(p.%3D) Ctg/Ttg chr7 55249034 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249034", "IGV") medium 0.238 2901 pass no call 8254 EGFR_E00001601336_1 ENSG00000146648 20 of 28 59 FFPE GCCTG C/T TGGGC CMDL150033 FLD0108 FLD0132 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.491 0.369 1512 1375 pass pass 28311 17273 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150033 FLD0108 FLD0132 synonymous EGFR c.2376C>T c.2376C>T(p.%3D) ctC/ctT chr7 55249078 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249078", "IGV") low 0.116 1375 no call QD 2514 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM3833028 15 FFPE CAGCT C/T ATGCC CMDL150033 FLD0108 FLD0132 synonymous EGFR c.2382C>T c.2382C>T(p.%3D) ccC/ccT chr7 55249084 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249084", "IGV") medium 0.144 1375 no call pass 3652 EGFR_E00001601336_1 ENSG00000146648 20 of 28 9 FFPE ATGCC C/T TTCGG CMDL150033 FLD0108 FLD0132 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.489 0.543 1537 1472 pass pass 27428 29138 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150033 FLD0108 FLD0132 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.456 0.578 1714 1521 pass pass 27352 32494 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150033 FLD0108 FLD0132 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.444 0.499 3771 3584 pass pass 32017 35571 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150033 FLD0108 FLD0132 intron TP53 c.97-45G>A chr17 7579635 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579635", "IGV") medium 0.227 369 pass no call 1353 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE TCAGC C/T CCCCA CMDL150033 FLD0108 FLD0132 intron TP53 c.96+16G>A chr17 7579684 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579684", "IGV") low 0.146 369 QD no call 558 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs730882012 benign 51 FFPE CAGCC C/T AACCC CMDL150033 FLD0108 FLD0132 synonymous PIK3CA c.1641G>A c.1641G>A(p.%3D) gaG/gaA chr3 178936099 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936099", "IGV") low 0.099 1148 QD no call 716 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM729820, COSM729819 28 FFPE CAGGA G/A AAAGA CMDL150033 FLD0108 FLD0132 stop_gained PIK3CA c.1655G>A p.W552* tGg/tAg chr3 178936113 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936113", "IGV") low 0.096 1250 no call QD 622 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 14 FFPE TCTAT G/A GAGTC CMDL150033 FLD0108 FLD0132 intron PTEN c.802-33A>G chr10 89720618 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89720618", "IGV") low 0.130 97 pass no call 210 PTEN_E00001156315_1m ENSG00000171862 7 of 8 67 FFPE ATTTC A/G TTTCT CMDL150033 FLD0108 FLD0132 intron PTEN c.801+22G>A chr10 89717798 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717798", "IGV") medium 0.138 1370 no call pass 4001 PTEN_E00001156321_4m ENSG00000171862 7 of 8 29 FFPE CATTG G/A GAGAA CMDL150033 FLD0108 FLD0132 intron PTEN c.801+25G>A chr10 89717801 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717801", "IGV") medium 0.135 1371 no call pass 3835 PTEN_E00001156321_4m ENSG00000171862 7 of 8 COSM5937 32 FFPE TGGGA G/A AAATA CMDL150033 FLD0108 FLD0132 intron PTEN c.801+112G>A chr10 89717888 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717888", "IGV") low 0.142 2726 no call QD 1094 PTEN_E00001156321_4m ENSG00000171862 7 of 8 46 FFPE CTGCA G/A GTGTT CMDL150033 FLD0108 FLD0132 nonsynonymous PTEN c.362C>T p.A121V gCa/gTa chr10 89692878 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692878", "IGV") low 0.127 1361 QD no call 2382 PTEN_E00001156330_3 ENSG00000171862 5 of 9 rs121909237, COSM5273 tolerated(0.42) possibly_damaging(0.669) pathogenic 15 FFPE TGCAG C/T AATTC CMDL150033 FLD0108 FLD0132 nonsynonymous PTEN c.402G>A p.M134I atG/atA chr10 89692918 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692918", "IGV") low 0.152 2691 QD no call 271 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM921092, COSM1561208 deleterious(0) possibly_damaging(0.824) 55 FFPE GTAAT G/A ATATG CMDL150033 FLD0108 FLD0132 nonsynonymous PTEN c.421C>T p.H141Y Cat/Tat chr10 89692937 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692937", "IGV") medium 0.238 2724 no call pass 7025 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5077, COSM1349537 tolerated(0.16) benign(0.086) 74 FFPE TATTA C/T ATCGG CMDL150033 FLD0108 FLD0132 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.094 995 no call QD 663 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150033 FLD0108 FLD0132 intron TP53 c.74+53C>T chr17 7579786 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579786", "IGV") medium 0.147 1000 no call pass 2743 TP53_E00001596491_1 ENSG00000141510 2 of 10 9 FFPE TAGGG G/A GCTGG CMDL150033 FLD0108 FLD0132 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.536 0.553 1879 1983 pass pass 23712 30798 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150033 FLD0108 FLD0132 intron TP53 c.74+36C>T chr17 7579803 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579803", "IGV") low 0.087 1983 no call QD 282 TP53_E00001596491_1 ENSG00000141510 2 of 10 26 FFPE GGTGG G/A GGTGG CMDL150033 FLD0108 FLD0132 intron TP53 c.74+29C>T chr17 7579810 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579810", "IGV") low 0.138 1983 no call QD 1012 TP53_E00001596491_1 ENSG00000141510 2 of 10 33 FFPE GTGGT G/A GGCCT CMDL150033 FLD0108 FLD0132 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.820 0.798 997 842 pass pass 20939 17407 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150033 FLD0108 FLD0132 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.151 2619 QD no call 1786 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150033 FLD0108 FLD0132 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.243 0.189 2619 2786 pass QD 12673 4507 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150033 FLD0108 FLD0132 3_prime_UTR TP53 c.*20C>T chr17 7572907 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572907", "IGV") low 0.195 2619 QD no call 5072 TP53_E00001757276_1 ENSG00000141510 11 of 11 38 FFPE AGTGG G/A GAACA CMDL150035 FLD0109 FLD0133 intron EGFR c.2284-42C>T chr7 55248944 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248944", "IGV") medium 0.213 1669 pass no call 8428 EGFR_E00001601336_1 ENSG00000146648 19 of 27 24 FFPE CTGGC C/T ACCAT CMDL150035 FLD0109 FLD0133 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.993 0.987 1566 1465 pass pass 65311 61991 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150035 FLD0109 FLD0133 synonymous EGFR c.2370G>A c.2370G>A(p.%3D) acG/acA chr7 55249072 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249072", "IGV") medium 0.153 1465 no call pass 3792 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs376452156 21 FFPE ATCAC G/A CAGCT CMDL150035 FLD0109 FLD0133 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.994 0.988 1614 1528 pass pass 74943 70512 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150035 FLD0109 FLD0133 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.997 0.984 1633 1585 pass pass 70117 66180 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150035 FLD0109 FLD0133 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.800 0.676 3861 3477 pass pass 85357 56529 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150035 FLD0109 FLD0133 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") high 0.327 0.948 1585 1225 pass pass 9701 34421 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL150035 FLD0109 FLD0133 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.111 1585 QD no call 591 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL150035 FLD0109 FLD0133 intron TP53 c.96+21G>A chr17 7579679 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579679", "IGV") medium 0.417 1585 pass no call 15882 EXP0116_TP53_E3 ENSG00000141510 3 of 10 56 FFPE GTCCC C/T AGCCC CMDL150035 FLD0109 FLD0133 splice_region,intron TP53 c.96+6G>A chr17 7579694 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579694", "IGV") medium 0.250 1585 pass no call 9938 EXP0116_TP53_E3 ENSG00000141510 3 of 10 41 FFPE CTTGT C/T CTTAC CMDL150035 FLD0109 FLD0133 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.983 1404 pass no call 56741 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150035 FLD0109 FLD0133 synonymous TP53 c.639A>G c.639A>G(p.%3D) cgA/cgG chr17 7578210 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578210", "IGV") medium 0.209 0.180 2733 2502 pass QD 5797 1788 TP53_E00001255919_1 20455025, 18798306, 15450681, 23543587, 24218030, 22829934, 18594532, 21869887, 17133269 ENSG00000141510 6 of 11 CX984230, rs1800372, TP53_g.12708A>T, COSM249885, COSM1741221, COSM1741223, COSM1741225, COSM3755916, COSM1741222, COSM1741224 benign C:0.0054 43 FFPE CTATG T/C CGAAA CMDL150035 FLD0109 FLD0133 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") medium 0.179 1086 pass no call 4226 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150035 FLD0109 FLD0133 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") low 0.175 0.177 2153 2224 QD QD 2688 2343 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150035 FLD0109 FLD0133 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") medium 0.377 2224 no call pass 14109 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL150035 FLD0109 FLD0133 intron TP53 c.74+36C>T chr17 7579803 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579803", "IGV") medium 0.203 2224 no call pass 12547 TP53_E00001596491_1 ENSG00000141510 2 of 10 26 FFPE GGTGG G/A GGTGG CMDL150035 FLD0109 FLD0133 intron TP53 c.74+31C>T chr17 7579808 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579808", "IGV") medium 0.194 2224 no call pass 4522 TP53_E00001596491_1 ENSG00000141510 2 of 10 31 FFPE GGGTG G/A TGGGC CMDL150035 FLD0109 FLD0133 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.335 0.356 457 436 pass pass 2428 2378 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150035 FLD0109 FLD0133 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") high 0.292 0.263 3241 2293 pass pass 14183 9071 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150035 FLD0109 FLD0133 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") low 0.138 2293 no call QD 1517 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL150035 FLD0109 FLD0133 3_prime_UTR TP53 c.*24C>T chr17 7572903 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572903", "IGV") low 0.139 2293 no call QD 1879 TP53_E00001757276_1 ENSG00000141510 11 of 11 34 FFPE TGTCA G/A TGGGG CMDL150038 FLD0110 FLD0134 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.518 0.511 1366 1572 pass pass 25554 28250 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150038 FLD0110 FLD0134 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.493 0.533 1476 1539 pass pass 25095 28383 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150038 FLD0110 FLD0134 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.995 0.994 1541 1561 pass pass 65543 66550 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150038 FLD0110 FLD0134 intron EGFR c.2848+15G>T chr7 55266571 G T =hyperlink("http://localhost:60151/goto?locus=chr7:55266571", "IGV") high 0.483 0.520 3578 3208 pass pass 33541 35931 EGFR_E00001779947_2 ENSG00000146648 23 of 27 rs376011908 53 FFPE TGGTG G/T GTCTG CMDL150038 FLD0110 FLD0134 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") low 0.153 991 no call QD 1483 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL150038 FLD0110 FLD0134 splice_region,intron PTEN c.802-8T>C chr10 89720643 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720643", "IGV") low 0.012 94 QD no call 149 PTEN_E00001156315_1m ENSG00000171862 7 of 8 42 FFPE TTTTT T/C TTTTT CMDL150038 FLD0110 FLD0134 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.087 905 QD no call 474 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150038 FLD0110 FLD0134 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.569 0.531 1805 1828 pass pass 24746 22297 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150038 FLD0110 FLD0134 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.851 0.866 879 1123 pass pass 20622 26006 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150062 FLD0111 FLD0135 synonymous BRAF c.1773A>G c.1773A>G(p.%3D) aaA/aaG chr7 140453162 T C =hyperlink("http://localhost:60151/goto?locus=chr7:140453162", "IGV") low 0.227 3397 QD no call 6242 BRAF_AA_HS ENSG00000157764 15 of 18 36 FFPE CCTAT T/C TTTAC CMDL150062 FLD0111 FLD0135 intron BRAF c.1742-26G>A chr7 140453219 C T =hyperlink("http://localhost:60151/goto?locus=chr7:140453219", "IGV") low 0.223 3397 QD no call 6028 BRAF_AA_HS ENSG00000157764 14 of 17 15 FFPE GAAAA C/T AGTAG CMDL150062 FLD0111 FLD0135 splice_region,intron EGFR c.2284-7C>T chr7 55248979 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248979", "IGV") low 0.084 3813 no call QD 2826 EGFR_E00001601336_1 ENSG00000146648 19 of 27 59 FFPE CCCTC C/T CTCCA CMDL150062 FLD0111 FLD0135 splice_region,intron EGFR c.2284-6C>T chr7 55248980 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248980", "IGV") low 0.086 3813 no call QD 2826 EGFR_E00001601336_1 ENSG00000146648 19 of 27 COSM1635349 60 FFPE CCTCC C/T TCCAG CMDL150062 FLD0111 FLD0135 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") medium 0.364 1835 no call pass 21083 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150062 FLD0111 FLD0135 nonsynonymous EGFR c.2369C>T p.T790M aCg/aTg chr7 55249071 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249071", "IGV") low 0.072 1835 no call QD 45 EGFR_E00001601336_1 ENSG00000146648 20 of 28 CM054664, rs121434569, COSM6240 deleterious(0) probably_damaging(1) likely_pathogenic,drug_response,protective 22 FFPE CATCA C/T GCAGC CMDL150062 FLD0111 FLD0135 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.997 0.489 354 1934 pass pass 15374 34119 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150062 FLD0111 FLD0135 synonymous EGFR c.2478C>T c.2478C>T(p.%3D) aaC/aaT chr7 55259420 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259420", "IGV") low 1.000 2 LowQual no call 22 EGFR_E00001681524_1 ENSG00000146648 21 of 28 49 FFPE ATGAA C/T TACTT CMDL150062 FLD0111 FLD0135 intron EGFR c.3115-51A>G chr7 55269377 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55269377", "IGV") low 0.187 3269 QD no call 3407 EGFR_E00001773562_1 ENSG00000146648 25 of 27 23 FFPE AGTGG A/G TGAGA CMDL150062 FLD0111 FLD0135 intron EGFR c.3115-18T>C chr7 55269410 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55269410", "IGV") low 0.106 3269 QD no call 5037 EGFR_E00001773562_1 ENSG00000146648 25 of 27 56 FFPE CAACT T/C CTCTG CMDL150062 FLD0111 FLD0135 splice_region,intron EGFR c.3115-4T>C chr7 55269424 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55269424", "IGV") low 0.105 3269 QD no call 5117 EGFR_E00001773562_1 ENSG00000146648 25 of 27 70 FFPE CTTTT T/C CAGAG CMDL150062 FLD0111 FLD0135 splice_region,intron EGFR c.3162+8T>G chr7 55269483 T G =hyperlink("http://localhost:60151/goto?locus=chr7:55269483", "IGV") low 0.207 3269 QD no call 5685 EGFR_E00001773562_1 ENSG00000146648 26 of 27 12 FFPE ATGTA T/G GAACA CMDL150062 FLD0111 FLD0135 intron EGFR c.3162+16T>C chr7 55269491 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55269491", "IGV") medium 0.191 1620 pass no call 7199 EGFR_E00001773562_1 ENSG00000146648 26 of 27 4 FFPE ACACC T/C TATAA CMDL150062 FLD0111 FLD0135 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") medium 0.491 1907 no call pass 33090 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150062 FLD0111 FLD0135 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") medium 0.419 1356 no call pass 8576 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL150062 FLD0111 FLD0135 intron TP53 c.96+22G>A chr17 7579678 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579678", "IGV") low 0.247 1356 no call QD 1510 EXP0116_TP53_E3 ENSG00000141510 3 of 10 57 FFPE GGTCC C/T CAGCC CMDL150062 FLD0111 FLD0135 synonymous PTEN c.711G>A c.711G>A(p.%3D) aaG/aaA chr10 89717686 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717686", "IGV") low 1.000 2 LowQual no call 22 PTEN_E00001156321_1 ENSG00000171862 7 of 9 rs773353820, COSM5806 21 FFPE GACAA G/A TTCAT CMDL150062 FLD0111 FLD0135 intron PTEN c.493-49A>T chr10 89711826 A T =hyperlink("http://localhost:60151/goto?locus=chr10:89711826", "IGV") medium 0.471 3967 pass no call 37611 PTEN_E00001156327_1 ENSG00000171862 5 of 8 31 FFPE CTATA A/T TGGAA CMDL150062 FLD0111 FLD0135 nonsynonymous PTEN c.500C>T p.T167I aCt/aTt chr10 89711882 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711882", "IGV") medium 0.471 3967 pass no call 34930 PTEN_E00001156327_1 ENSG00000171862 6 of 9 rs397514559, COSM35753, COSM35323 deleterious(0.02) possibly_damaging(0.742) pathogenic 36 FFPE AGTAA C/T TATTC CMDL150062 FLD0111 FLD0135 nonsynonymous PTEN c.389G>A p.R130Q cGa/cAa chr10 89692905 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692905", "IGV") medium 0.272 3444 no call pass 11943 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CM991081, rs121909229, rs121913292, CM981670, COSM5817, COSM5033, COSM5277, COSM5216 deleterious(0.02) probably_damaging(0.989) likely_pathogenic,pathogenic,pathogenic 42 FFPE GGGAC G/A AACTG CMDL150062 FLD0111 FLD0135 nonsynonymous PTEN c.235G>A p.A79T Gcc/Acc chr10 89690828 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89690828", "IGV") low 1.000 2 LowQual no call 22 PTEN_E00001156337_4 ENSG00000171862 4 of 9 rs202004587, CM022240, COSM5040 tolerated(0.59) benign(0.005) uncertain_significance,pathogenic 20 FFPE ACACC G/A CCAAA CMDL150062 FLD0111 FLD0135 intron PTEN c.253+19T>C chr10 89690865 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89690865", "IGV") low 1.000 2 LowQual no call 22 PTEN_E00001156337_4 ENSG00000171862 4 of 8 47 FFPE TACTG T/C ACTAT CMDL150062 FLD0111 FLD0135 intron PTEN c.253+57T>C chr10 89690903 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89690903", "IGV") low 1.000 2 LowQual no call 22 PTEN_E00001156337_4 ENSG00000171862 4 of 8 9 FFPE TATCT T/C ACTGT CMDL150062 FLD0111 FLD0135 nonsynonymous PTEN c.95T>G p.I32S aTt/aGt chr10 89653797 T G =hyperlink("http://localhost:60151/goto?locus=chr10:89653797", "IGV") low 0.170 4260 no call QD 1334 PTEN_E00001156351_1 ENSG00000171862 2 of 9 CM110156 deleterious(0) probably_damaging(0.939) 30 FFPE AAACA T/G TATTG CMDL150062 FLD0111 FLD0135 nonsynonymous PTEN c.133G>A p.V45I Gta/Ata chr10 89653835 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89653835", "IGV") low 0.167 4260 no call QD 2081 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM1349477, COSM249824, COSM921065 tolerated(0.2) benign(0.009) 62 FFPE AAGGC G/A TATAC CMDL150062 FLD0111 FLD0135 synonymous TP53 c.456G>A c.456G>A(p.%3D) ccG/ccA chr17 7578474 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578474", "IGV") low 1.000 2 LowQual no call 22 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12444G>C, TP53_g.12444G>A, TP53_g.12444del, TP53_g.12444G>T, COSM44061, COSM44958, COSM45197, COSM1640854, COSM1640856, COSM1640858, COSM1640855, COSM1640857 35 FFPE CCGGG C/T GGGGG CMDL150062 FLD0111 FLD0135 nonsynonymous TP53 c.422G>A p.C141Y tGc/tAc chr17 7578508 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578508", "IGV") low 1.000 2 LowQual no call 22 TP53_E00001255919_5 ENSG00000141510 5 of 11 rs587781288, CM993216, TP53_g.12410G>T, TP53_g.12410G>A, TP53_g.12410G>C, COSM293910, COSM44911, COSM43708, COSM1559491, COSM131470, COSM293912, COSM1559492, COSM131471, COSM293911, COSM131473, COSM293913, COSM1559494, COSM3378367, COSM3378366, COSM131472, COSM293914, COSM1559493 deleterious(0) probably_damaging(1) pathogenic 1 FFPE CAGGG C/T AGGTC CMDL150062 FLD0111 FLD0135 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.084 1506 no call QD 510 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150062 FLD0111 FLD0135 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") medium 0.995 3016 no call pass 109736 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150062 FLD0111 FLD0135 intron TP53 c.74+36C>T chr17 7579803 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579803", "IGV") low 0.132 3016 no call LowQual,QD 19 TP53_E00001596491_1 ENSG00000141510 2 of 10 26 FFPE GGTGG G/A GGTGG CMDL150062 FLD0111 FLD0135 nonsynonymous TP53 c.311A>G p.Q104R cAg/cGg chr17 7579376 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7579376", "IGV") low 1.000 2 pass no call 63 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11542A>T, TP53_g.11542del, COSM307328, COSM85858 deleterious(0.04) benign(0.007) 30 FFPE TGCCC T/C GGTAG CMDL150062 FLD0111 FLD0135 stop_gained TP53 c.298C>T p.Q100* Cag/Tag chr17 7579389 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579389", "IGV") low 1.000 2 pass no call 63 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11529C>T, TP53_g.11529del, COSM44032, COSM1189391, COSM1189392 17 FFPE TTTCT G/A GGAAG CMDL150062 FLD0111 FLD0135 synonymous TP53 c.294T>G c.294T>G(p.%3D) ccT/ccG chr17 7579393 A C =hyperlink("http://localhost:60151/goto?locus=chr17:7579393", "IGV") low 1.000 2 LowQual no call 22 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11525T>A, COSM1564169, COSM1564170, COSM1564171 16 FFPE TGGGA A/C GGGAC CMDL150062 FLD0111 FLD0135 synonymous TP53 c.267C>T c.267C>T(p.%3D) ccC/ccT chr17 7579420 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579420", "IGV") low 1.000 2 LowQual no call 22 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs587783062, TP53_g.11498C>T, TP53_g.11498del, COSM1268330, COSM1180853, COSM1180854 likely_pathogenic 43 FFPE CAGGA G/A GGGGC CMDL150062 FLD0111 FLD0135 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") medium 1.000 0.998 2 1249 pass pass 63 41566 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150062 FLD0111 FLD0135 synonymous TP53 c.192C>T c.192C>T(p.%3D) ccC/ccT chr17 7579495 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579495", "IGV") low 1.000 2 pass no call 63 TP53_E00001612188_2 ENSG00000141510 4 of 11 CD065798 6 FFPE ATTCT G/A GGAGC CMDL150062 FLD0111 FLD0135 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.112 3391 no call QD 833 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150062 FLD0111 FLD0135 3_prime_UTR TP53 c.*34C>T chr17 7572893 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572893", "IGV") low 0.111 3391 no call QD 2206 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs545818827 A:0.0002 24 FFPE GGTGG G/A AGGCT CMDL150070 FLD0112 FLD0136 intron BRAF c.1742-19T>C chr7 140453212 A G =hyperlink("http://localhost:60151/goto?locus=chr7:140453212", "IGV") low 0.150 721 QD no call 433 BRAF_AA_HS ENSG00000157764 14 of 17 22 FFPE AGTAA A/G GGAAA CMDL150070 FLD0112 FLD0136 synonymous EGFR c.2307G>A c.2307G>A(p.%3D) gtG/gtA chr7 55249009 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249009", "IGV") low 0.311 403 FS no call 4226 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs757699292, COSM1451596 84 FFPE AGCGT G/A GACAA CMDL150070 FLD0112 FLD0136 nonsynonymous EGFR c.2356G>A p.V786M Gtg/Atg chr7 55249058 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249058", "IGV") medium 0.206 287 pass no call 915 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs762672864, COSM27110 deleterious(0) probably_damaging(0.96) 35 FFPE CCACC G/A TGCAG CMDL150070 FLD0112 FLD0136 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.680 0.462 287 1774 pass pass 6697 27610 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150070 FLD0112 FLD0136 synonymous EGFR c.2343C>T c.2343C>T(p.%3D) tgC/tgT chr7 55249045 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249045", "IGV") medium 0.424 244 pass no call 3686 EGFR_E00001601336_2 ENSG00000146648 20 of 28 24 FFPE ATCTG C/T CTCAC CMDL150070 FLD0112 FLD0136 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.475 0.508 251 1666 pass pass 4781 30266 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150070 FLD0112 FLD0136 intron EGFR c.2469+16A>T chr7 55249187 A T =hyperlink("http://localhost:60151/goto?locus=chr7:55249187", "IGV") low 0.100 242 QD no call 303 EGFR_E00001601336_2 ENSG00000146648 20 of 27 8 FFPE AAGGG A/T GATAC CMDL150070 FLD0112 FLD0136 intron EGFR c.2626-58T>C chr7 55260401 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55260401", "IGV") low 0.102 409 QD no call 353 EGFR_E00001631695_1 ENSG00000146648 21 of 27 14 FFPE TAACT T/C TTTCC CMDL150070 FLD0112 FLD0136 nonsynonymous EGFR c.2684G>A p.S895N aGt/aAt chr7 55260517 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260517", "IGV") low 0.121 408 QD no call 436 EGFR_E00001631695_1 ENSG00000146648 22 of 28 deleterious(0.02) probably_damaging(0.999) 36 FFPE CCAGA G/A TGATG CMDL150070 FLD0112 FLD0136 nonsynonymous EGFR c.2690T>C p.V897A gTc/gCc chr7 55260523 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55260523", "IGV") low 0.085 407 QD no call 113 EGFR_E00001631695_1 ENSG00000146648 22 of 28 deleterious(0) probably_damaging(1) 30 FFPE TGATG T/C CTGGA CMDL150070 FLD0112 FLD0136 splice_region,intron EGFR c.2701+7C>T chr7 55260541 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260541", "IGV") low 0.097 407 QD no call 316 EGFR_E00001631695_1 ENSG00000146648 22 of 27 12 FFPE TGAGT C/T ATAAT CMDL150070 FLD0112 FLD0136 intron EGFR c.2470-36G>A chr7 55259376 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259376", "IGV") low 0.124 397 QD no call 642 EGFR_E00001681524_1 ENSG00000146648 20 of 27 5 FFPE ATGAT G/A ATCTG CMDL150070 FLD0112 FLD0136 intron EGFR c.2470-32T>C chr7 55259380 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55259380", "IGV") medium 0.164 397 pass no call 1295 EGFR_E00001681524_1 ENSG00000146648 20 of 27 9 FFPE TGATC T/C GTCCC CMDL150070 FLD0112 FLD0136 splice_region,synonymous EGFR c.2472C>T c.2472C>T(p.%3D) ggC/ggT chr7 55259414 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259414", "IGV") low 0.152 790 QD no call 428 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM53233 43 FFPE CAGGG C/T ATGAA CMDL150070 FLD0112 FLD0136 synonymous EGFR c.3141G>A c.3141G>A(p.%3D) gtG/gtA chr7 55269454 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269454", "IGV") low 0.153 690 QD no call 1239 EGFR_E00001773562_1 ENSG00000146648 26 of 28 41 FFPE ACCGT G/A GCTTG CMDL150070 FLD0112 FLD0136 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.987 0.996 226 1746 pass pass 9472 74341 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150070 FLD0112 FLD0136 nonsynonymous EGFR c.2746G>A p.D916N Gac/Aac chr7 55266454 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266454", "IGV") low 0.125 453 LowQual,QD no call 15 EGFR_E00001779947_1 ENSG00000146648 23 of 28 rs376822837 deleterious(0) probably_damaging(0.973) 71 FFPE CATAT G/A ACGGA CMDL150070 FLD0112 FLD0136 nonsynonymous EGFR c.2758G>A p.A920T Gcc/Acc chr7 55266466 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266466", "IGV") low 0.181 453 QD no call 689 EGFR_E00001779947_1 ENSG00000146648 23 of 28 tolerated(0.38) probably_damaging(0.998) 83 FFPE TCCCT G/A CCAGC CMDL150070 FLD0112 FLD0136 nonsynonymous EGFR c.2809C>T p.P937S Ccc/Tcc chr7 55266517 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266517", "IGV") low 0.129 764 QD no call 34 EGFR_E00001779947_2 ENSG00000146648 23 of 28 deleterious(0.01) probably_damaging(1) 41 FFPE AGCCA C/T CCATA CMDL150070 FLD0112 FLD0136 intron EGFR c.2849-14C>T chr7 55267995 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55267995", "IGV") low 0.143 693 QD no call 624 EGFR_E00001790701_1 ENSG00000146648 23 of 27 37 FFPE TTTCT C/T ATTCC CMDL150070 FLD0112 FLD0136 intron EGFR c.2849-12T>C chr7 55267997 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55267997", "IGV") medium 0.149 693 pass no call 2141 EGFR_E00001790701_1 ENSG00000146648 23 of 27 39 FFPE TCTCA T/C TCCTT CMDL150070 FLD0112 FLD0136 synonymous EGFR c.2925C>T c.2925C>T(p.%3D) ccC/ccT chr7 55268085 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268085", "IGV") medium 0.150 348 pass no call 888 EGFR_E00001790701_1 ENSG00000146648 24 of 28 rs778672343 29 FFPE GACCC C/T CAGCG CMDL150070 FLD0112 FLD0136 nonsynonymous EGFR c.2965T>A p.L989M Ttg/Atg chr7 55268899 T A =hyperlink("http://localhost:60151/goto?locus=chr7:55268899", "IGV") low 0.198 901 QD no call 1199 EGFR_E00001801208_1 ENSG00000146648 25 of 28 tolerated(0.06) probably_damaging(0.995) 69 FFPE TGCAT T/A TGCCA CMDL150070 FLD0112 FLD0136 nonsynonymous EGFR c.3014A>G p.E1005G gAa/gGa chr7 55268948 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55268948", "IGV") low 0.207 901 QD no call 1425 EGFR_E00001801208_1 ENSG00000146648 25 of 28 tolerated(0.08) benign(0.002) 20 FFPE TGAAG A/G AGACA CMDL150070 FLD0112 FLD0136 nonsynonymous EGFR c.3025G>A p.D1009N Gac/Aac chr7 55268959 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268959", "IGV") medium 0.319 441 pass no call 4304 EGFR_E00001801208_1 ENSG00000146648 25 of 28 rs148019583, COSM3639757 deleterious(0.03) possibly_damaging(0.813) 9 FFPE TGGAC G/A ACGTG CMDL150070 FLD0112 FLD0136 synonymous EGFR c.3018C>T c.3018C>T(p.%3D) gaC/gaT chr7 55268952 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268952", "IGV") medium 0.240 664 pass no call 1424 EGFR_E00001801208_2 ENSG00000146648 25 of 28 14 FFPE GAAGA C/T ATGGA CMDL150070 FLD0112 FLD0136 synonymous EGFR c.3063G>A c.3063G>A(p.%3D) caG/caA chr7 55268997 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268997", "IGV") medium 0.226 669 pass no call 1567 EGFR_E00001801208_2 ENSG00000146648 25 of 28 59 FFPE CAGCA G/A GGCTT CMDL150070 FLD0112 FLD0136 nonsynonymous EGFR c.2227G>A p.A743T Gct/Act chr7 55242457 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55242457", "IGV") medium 0.148 979 pass no call 2237 EGFR_Exon19 ENSG00000146648 19 of 28 rs759256622, COSM26509 deleterious(0) probably_damaging(1) 61 FFPE CCGTC G/A CTATC CMDL150070 FLD0112 FLD0136 intron TP53 c.96+13G>A chr17 7579687 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579687", "IGV") low 0.076 774 no call QD 185 EXP0116_TP53_E3 ENSG00000141510 3 of 10 48 FFPE CCCAA C/T CCTTG CMDL150070 FLD0112 FLD0136 nonsynonymous TP53 c.91G>T p.V31F Gtt/Ttt chr17 7579705 C A =hyperlink("http://localhost:60151/goto?locus=chr17:7579705", "IGV") low 0.107 774 no call QD 351 EXP0116_TP53_E3 ENSG00000141510 3 of 11 rs201753350, CM074603, TP53_g.11213G>A, COSM45360, COSM1717726, COSM1717728, COSM1717727, COSM1717729 tolerated(0.08) benign(0.232) uncertain_significance,not_provided,likely_benign T:0.0018 30 FFPE CAGAA C/A GTTGT CMDL150070 FLD0112 FLD0136 stop_gained TP53 c.154C>T p.Q52* Caa/Taa chr17 7579533 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579533", "IGV") low 0.146 704 QD no call 533 EXP0116_TP53_E4 ENSG00000141510 4 of 11 TP53_g.11385C>T, COSM44041, COSM99949, COSM99948, COSM3932748, COSM1750375 37 FFPE CCATT G/A TTCAA CMDL150070 FLD0112 FLD0136 nonsynonymous TP53 c.140C>T p.P47L cCg/cTg chr17 7579547 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579547", "IGV") medium 0.207 704 pass no call 1747 EXP0116_TP53_E4 ENSG00000141510 4 of 11 TP53_g.11371C>T, COSM13161, COSM44040, COSM318371, COSM318370 tolerated(0.11) benign(0.054) 51 FFPE CGTCC G/A GGGAC CMDL150070 FLD0112 FLD0136 synonymous TP53 c.108G>A c.108G>A(p.%3D) ccG/ccA chr17 7579579 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579579", "IGV") high 0.778 0.515 704 3607 pass pass 17432 37867 EXP0116_TP53_E4 18798306, 15450681, 21115003, 23570263, 17133269 ENSG00000141510 4 of 11 rs1800370, TP53_g.11339G>A, TP53_g.11339G>T benign T:0.0076 28 FFPE TGGGA C/T GGCAA CMDL150070 FLD0112 FLD0136 intron PTEN c.802-103A>G chr10 89720548 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89720548", "IGV") medium 0.209 264 pass no call 1521 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs570023843 G:0.0052 68 FFPE TTGCA A/G ATGTT CMDL150070 FLD0112 FLD0136 intron PTEN c.802-63T>C chr10 89720588 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720588", "IGV") medium 0.150 274 pass no call 629 PTEN_E00001156315_1m ENSG00000171862 7 of 8 97 FFPE AAAAA T/C AAAAC CMDL150070 FLD0112 FLD0136 nonsynonymous PTEN c.807A>T p.K269N aaA/aaT chr10 89720656 A T =hyperlink("http://localhost:60151/goto?locus=chr10:89720656", "IGV") low 0.211 11 pass no call 249 PTEN_E00001156315_1m ENSG00000171862 8 of 9 deleterious(0.04) benign(0.366) 29 FFPE GACAA A/T ATGTT CMDL150070 FLD0112 FLD0136 intron PTEN c.1026+9A>G chr10 89720884 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89720884", "IGV") low 0.102 516 QD no call 255 PTEN_E00001156315_7 ENSG00000171862 8 of 8 12 FFPE AGTTA A/G ATTAA CMDL150070 FLD0112 FLD0136 synonymous PTEN c.699A>G c.699A>G(p.%3D) cgA/cgG chr10 89717674 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717674", "IGV") low 0.116 673 QD no call 1067 PTEN_E00001156321_1 ENSG00000171862 7 of 9 COSM1561199 33 FFPE ACACG A/G CGGGA CMDL150070 FLD0112 FLD0136 nonsynonymous PTEN c.707A>G p.D236G gAc/gGc chr10 89717682 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717682", "IGV") low 0.114 673 QD no call 978 PTEN_E00001156321_1 ENSG00000171862 7 of 9 tolerated(0.2) benign(0.005) 25 FFPE GGAAG A/G CAAGT CMDL150070 FLD0112 FLD0136 synonymous PTEN c.783G>A c.783G>A(p.%3D) caG/caA chr10 89717758 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717758", "IGV") low 0.140 543 QD no call 62 PTEN_E00001156321_2 ENSG00000171862 7 of 9 rs760146269, CD972422 18 FFPE AAACA G/A AACAA CMDL150070 FLD0112 FLD0136 synonymous PTEN c.793C>T c.793C>T(p.%3D) Cta/Tta chr10 89717768 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717768", "IGV") low 0.173 543 QD no call 811 PTEN_E00001156321_2 ENSG00000171862 7 of 9 8 FFPE AGATG C/T TAAAA CMDL150070 FLD0112 FLD0136 intron PTEN c.801+23G>A chr10 89717799 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717799", "IGV") medium 0.172 323 pass no call 1118 PTEN_E00001156321_4m ENSG00000171862 7 of 8 rs116160352 benign A:0.0008 30 FFPE ATTGG G/A AGAAA CMDL150070 FLD0112 FLD0136 intron PTEN c.801+41G>A chr10 89717817 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717817", "IGV") medium 0.314 647 pass no call 3316 PTEN_E00001156321_4m ENSG00000171862 7 of 8 48 FFPE AATAA G/A GACAG CMDL150070 FLD0112 FLD0136 intron PTEN c.801+150G>A chr10 89717926 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717926", "IGV") medium 0.137 324 pass no call 666 PTEN_E00001156321_4m ENSG00000171862 7 of 8 8 FFPE TATAA G/A GGTAA CMDL150070 FLD0112 FLD0136 synonymous PTEN c.612A>G c.612A>G(p.%3D) ccA/ccG chr10 89711994 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89711994", "IGV") medium 0.493 816 pass no call 7990 PTEN_E00001156327_4 ENSG00000171862 6 of 9 rs539074063, COSM1349568 G:0.0002 56 FFPE ATTCC A/G ATGTT CMDL150070 FLD0112 FLD0136 nonsynonymous PTEN c.271G>A p.E91K Gaa/Aaa chr10 89692787 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692787", "IGV") low 0.181 800 QD no call 1218 PTEN_E00001156330_1 ENSG00000171862 5 of 9 COSM5299, COSM5202 tolerated(0.21) benign(0.02) 20 FFPE CTTTT G/A AAGAC CMDL150070 FLD0112 FLD0136 nonsynonymous PTEN c.377C>T p.A126V gCt/gTt chr10 89692893 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692893", "IGV") low 0.122 1709 no call QD 2131 PTEN_E00001156330_1 ENSG00000171862 5 of 9 COSM28884, COSM5041 deleterious(0.03) probably_damaging(0.965) 6 FFPE TAAAG C/T TGGAA CMDL150070 FLD0112 FLD0136 nonsynonymous PTEN c.377C>T p.A126V gCt/gTt chr10 89692893 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692893", "IGV") low 0.125 1457 no call QD 2015 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM28884, COSM5041 deleterious(0.03) probably_damaging(0.965) 30 FFPE TAAAG C/T TGGAA CMDL150070 FLD0112 FLD0136 synonymous PTEN c.426G>A c.426G>A(p.%3D) cgG/cgA chr10 89692942 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692942", "IGV") medium 0.128 695 pass no call 1940 PTEN_E00001156330_3 ENSG00000171862 5 of 9 79 FFPE CATCG G/A GGCAA CMDL150070 FLD0112 FLD0136 nonsynonymous PTEN c.451G>A p.A151T Gcc/Acc chr10 89692967 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692967", "IGV") medium 0.125 695 pass no call 1844 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5080 deleterious(0) probably_damaging(0.955) 58 FFPE AAGAG G/A CCCTA CMDL150070 FLD0112 FLD0136 nonsynonymous PTEN c.460T>C p.F154L Ttc/Ctc chr10 89692976 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89692976", "IGV") medium 0.131 695 pass no call 1852 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM1577265 tolerated(0.07) benign(0.034) 49 FFPE TAGAT T/C TCTAT CMDL150070 FLD0112 FLD0136 nonsynonymous PTEN c.472G>A p.V158I Gta/Ata chr10 89692988 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692988", "IGV") medium 0.210 695 pass no call 3278 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CM001319 tolerated(0.16) benign(0.065) 37 FFPE GGGAA G/A TAAGG CMDL150070 FLD0112 FLD0136 splice_donor PTEN c.492+2T>A chr10 89693010 T A =hyperlink("http://localhost:60151/goto?locus=chr10:89693010", "IGV") low 0.107 340 QD no call 343 PTEN_E00001156330_3 ENSG00000171862 5 of 8 CS982333, CD115958, COSM5980, COSM5967 15 FFPE AAAGG T/A AAGTT CMDL150070 FLD0112 FLD0136 intron PTEN c.209+14C>T chr10 89685328 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89685328", "IGV") medium 0.134 415 pass no call 923 PTEN_E00001156344_1 ENSG00000171862 3 of 8 rs773955737 11 FFPE GTTTT C/T TTATT CMDL150070 FLD0112 FLD0136 nonsynonymous PTEN c.1034T>C p.L345P cTg/cCg chr10 89725051 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89725051", "IGV") low 0.164 699 QD no call 1168 PTEN_E00001456541_1 ENSG00000171862 9 of 9 CM115950, COSM5213, COSM1561193 deleterious(0) benign(0.211) 29 FFPE GAAGC T/C GTACT CMDL150070 FLD0112 FLD0136 nonsynonymous PTEN c.1088C>T p.T363I aCt/aTt chr10 89725105 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725105", "IGV") low 0.105 436 QD no call 390 PTEN_E00001456541_2 ENSG00000171862 9 of 9 rs750585255 tolerated(0.13) benign(0.007) 17 FFPE TTCAA C/T TTCTG CMDL150070 FLD0112 FLD0136 synonymous PTEN c.1209C>T c.1209C>T(p.%3D) gtC/gtT chr10 89725226 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725226", "IGV") low 0.085 436 QD no call 92 PTEN_E00001456541_2 ENSG00000171862 9 of 9 15 FFPE AAAGT C/T TGAAT CMDL150070 FLD0112 FLD0136 synonymous PTEN c.9C>T c.9C>T(p.%3D) gcC/gcT chr10 89624235 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624235", "IGV") medium 0.316 557 pass no call 2811 PTEN_E00001456562_1 ENSG00000171862 1 of 9 COSM1561221 41 FFPE ACAGC C/T ATCAT CMDL150070 FLD0112 FLD0136 nonsynonymous,splice_region PTEN c.77C>T p.T26I aCc/aTc chr10 89624303 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624303", "IGV") low 0.177 557 QD no call 509 PTEN_E00001456562_1 ENSG00000171862 1 of 9 COSM1349469 deleterious(0.05) benign(0.067) 50 FFPE CTTGA C/T CTGTA CMDL150070 FLD0112 FLD0136 intron PTEN c.79+30C>T chr10 89624335 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624335", "IGV") medium 0.321 287 pass no call 2947 PTEN_E00001456562_1 ENSG00000171862 1 of 8 rs750009848 18 FFPE CTTTA C/T CTTTC CMDL150070 FLD0112 FLD0136 splice_region,intron TP53 c.560-8G>A chr17 7578297 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578297", "IGV") low 0.214 870 QD no call 1589 TP53_E00001255919_3 ENSG00000141510 5 of 10 rs373797299 G:0.0004 48 FFPE AAGAG C/T AATCA CMDL150070 FLD0112 FLD0136 intron TP53 c.560-33C>T chr17 7578322 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578322", "IGV") medium 0.337 870 pass no call 5607 TP53_E00001255919_3 ENSG00000141510 5 of 10 68 FFPE GCCTG G/A GGACC CMDL150070 FLD0112 FLD0136 splice_region,intron TP53 c.559+6C>T chr17 7578365 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578365", "IGV") low 0.161 870 QD no call 614 TP53_E00001255919_3 ENSG00000141510 5 of 10 rs370546196 25 FFPE CAGCT G/A CTCAC CMDL150070 FLD0112 FLD0136 nonsynonymous TP53 c.478A>G p.M160V Atg/Gtg chr17 7578452 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578452", "IGV") medium 0.235 735 pass no call 1826 TP53_E00001255919_5 ENSG00000141510 5 of 11 rs377274728, TP53_g.12466A>T, TP53_g.12466A>G, TP53_g.12466A>C, TP53_g.12466del, COSM44328, COSM45112, COSM44842 tolerated(0.15) possibly_damaging(0.676) 57 FFPE GGCCA T/C GGCGC CMDL150070 FLD0112 FLD0136 nonsynonymous TP53 c.436T>C p.W146R Tgg/Cgg chr17 7578494 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7578494", "IGV") low 0.186 735 QD no call 850 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12424T>A, TP53_g.12424T>C, TP53_g.12424T>G, COSM46219, COSM44555, COSM44553 tolerated(0.71) benign(0.405) 15 FFPE AACCC A/G CAGCT CMDL150070 FLD0112 FLD0136 nonsynonymous TP53 c.424C>T p.P142S Cct/Tct chr17 7578506 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578506", "IGV") low 0.172 735 QD no call 605 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12412C>T, TP53_g.12412C>G, TP53_g.12412C>A, TP53_g.12412del, COSM45927, COSM44969, COSM44520, COSM44927 deleterious(0) probably_damaging(1) 3 FFPE CACAG G/A GCAGG CMDL150070 FLD0112 FLD0136 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.078 1105 no call QD 367 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150070 FLD0112 FLD0136 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") medium 0.573 2220 no call pass 32195 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150070 FLD0112 FLD0136 intron TP53 c.375+9C>T chr17 7579303 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579303", "IGV") medium 0.788 416 pass no call 7451 TP53_E00001612188_1 ENSG00000141510 4 of 10 24 FFPE TCAGG G/A CAACT CMDL150070 FLD0112 FLD0136 nonsynonymous TP53 c.278T>C p.L93P cTg/cCg chr17 7579409 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7579409", "IGV") low 1.000 2 pass no call 63 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11509T>C, TP53_g.11509del tolerated(0.08) probably_damaging(0.98) 32 FFPE ATGAC A/G GGGGC CMDL150070 FLD0112 FLD0136 nonsynonymous TP53 c.259C>T p.P87S Cca/Tca chr17 7579428 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579428", "IGV") low 1.000 2 pass no call 63 TP53_E00001612188_2 ENSG00000141510 4 of 11 tolerated(0.36) possibly_damaging(0.45) 51 FFPE GGCTG G/A TGCAG CMDL150070 FLD0112 FLD0136 nonsynonymous TP53 c.253C>T p.P85S Cct/Tct chr17 7579434 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579434", "IGV") low 1.000 2 pass no call 63 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11484del, TP53_g.11484C>T, COSM45918 tolerated(0.51) benign(0.019) 57 FFPE TGCAG G/A GGCCG CMDL150070 FLD0112 FLD0136 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") medium 1.000 0.810 2 1025 LowQual pass 22 22632 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150070 FLD0112 FLD0136 intron TP53 c.782+14T>C chr17 7577485 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7577485", "IGV") medium 0.528 283 pass no call 2800 TP53_E00001665758_1 ENSG00000141510 7 of 10 36 FFPE GTGGC A/G AGTGG CMDL150070 FLD0112 FLD0136 nonsynonymous TP53 c.773A>T p.E258V gAa/gTa chr17 7577508 T A =hyperlink("http://localhost:60151/goto?locus=chr17:7577508", "IGV") medium 0.526 283 pass no call 3246 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13410A>G, TP53_g.13410A>C, TP53_g.13410A>T, COSM44168, COSM44719, COSM44450, COSM1268361, COSM1564205, COSM1564206, COSM1268362 deleterious(0) probably_damaging(0.998) 59 FFPE AGTCT T/A CCAGT CMDL150070 FLD0112 FLD0136 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.942 660 pass no call 17554 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150070 FLD0112 FLD0136 stop_gained TP53 c.1141A>T p.K381* Aaa/Taa chr17 7572968 T A =hyperlink("http://localhost:60151/goto?locus=chr17:7572968", "IGV") medium 0.308 660 pass no call 3571 TP53_E00001757276_1 ENSG00000141510 11 of 11 TP53_g.17950del, COSM45874 43 FFPE TTTTT T/A ATGGC CMDL150070 FLD0112 FLD0136 intron TP53 c.993+12T>C chr17 7576841 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7576841", "IGV") high 0.998 0.504 850 4479 pass pass 26651 43944 TP53_E00001789298_1 22829934 ENSG00000141510 9 of 10 rs1800899 benign G:0.0162 35 FFPE GTCCC A/G AGACT CMDL150070 FLD0112 FLD0136 intron TP53 c.920-11C>T chr17 7576937 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576937", "IGV") medium 0.813 410 pass no call 15359 TP53_E00001789298_1 ENSG00000141510 8 of 10 27 FFPE AAAGA G/A GCAAG CMDL150070 FLD0112 FLD0136 splice_region,intron TP53 c.920-4C>T chr17 7576930 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576930", "IGV") low 0.190 768 QD no call 550 TP53_E00001789298_2 ENSG00000141510 8 of 10 5 FFPE TGCTA G/A GAAAG CMDL150070 FLD0112 FLD0136 intron TP53 c.920-44T>C chr17 7576970 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7576970", "IGV") low 0.158 768 QD no call 203 TP53_E00001789298_2 ENSG00000141510 8 of 10 45 FFPE GAGGC A/G TAACT CMDL150070 FLD0112 FLD0136 nonsynonymous TP53 c.880G>A p.E294K Gag/Aag chr17 7577058 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577058", "IGV") medium 0.255 570 pass no call 4333 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13860G>C, TP53_g.13860G>T, TP53_g.13860G>A, TP53_g.13860del, COSM10856, COSM44127, COSM6621, COSM45824, COSM126981, COSM318363, COSM3388169, COSM2744501 tolerated(0.4) benign(0.179) 36 FFPE AGGCT C/T CCCTT CMDL150070 FLD0112 FLD0136 nonsynonymous TP53 c.856G>A p.E286K Gaa/Aaa chr17 7577082 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577082", "IGV") medium 0.247 570 pass no call 4562 TP53_E00001789298_3 ENSG00000141510 8 of 11 CM076567, TP53_g.13836G>C, TP53_g.13836del, TP53_g.13836G>T, TP53_g.13836G>A, COSM44250, COSM10726, COSM43919, COSM45277, COSM99924, COSM1480057, COSM318163, COSM3522693, COSM1645467, COSM1649346 deleterious(0) probably_damaging(0.982) 60 FFPE CTCTT C/T CTCTG CMDL150070 FLD0112 FLD0136 nonsynonymous TP53 c.841G>A p.D281N Gac/Aac chr17 7577097 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577097", "IGV") medium 0.236 570 pass no call 2731 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs764146326, CM076566, TP53_g.13821G>T, TP53_g.13821G>A, TP53_g.13821G>C, COSM11516, COSM43596, COSM10943, COSM146336, COSM214193, COSM1158315, COSM3388352, COSM3932743, COSM3820706, COSM2152580, COSM1649341, COSM1646814 deleterious(0.01) probably_damaging(0.996) 70 FFPE CCGGT C/T TCTCC CMDL150070 FLD0112 FLD0136 nonsynonymous TP53 c.832C>T p.P278S Cct/Tct chr17 7577106 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577106", "IGV") low 0.113 570 QD no call 116 TP53_E00001789298_3 25105660 ENSG00000141510 8 of 11 CM052927, CX0910928, rs17849781, CM011015, TP53_g.13812C>G, TP53_g.13812C>A, TP53_g.13812del, TP53_g.13812C>T, COSM43697, COSM10939, COSM10814, COSM45178, COSM368635, COSM139044, COSM99725, COSM3421932, COSM3773297, COSM3717626, COSM1646810, COSM1646809, COSM3421931 deleterious(0.03) probably_damaging(1) 61 FFPE CCCAG G/A ACAGG CMDL150091 FLD0113 FLD0137 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.501 0.513 1562 1958 pass pass 27620 35796 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150091 FLD0113 FLD0137 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.539 0.519 1394 1834 pass pass 26881 34648 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150091 FLD0113 FLD0137 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.992 0.994 1517 1857 pass pass 64159 78641 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150091 FLD0113 FLD0137 nonsynonymous PIK3CA c.3140A>G p.H1047R cAt/cGt chr3 178952085 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178952085", "IGV") high 0.423 0.418 2697 3507 pass pass 20204 24152 PIK3CA_Exn21_gap 25710561 ENSG00000121879 21 of 21 rs121913279, COSM776, COSM775, COSM249874, COSM94987, COSM94986 tolerated(0.11) possibly_damaging(0.529) pathogenic 28 FFPE TGCAC A/G TCATG CMDL150091 FLD0113 FLD0137 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.007 1200 no call QD 557 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL150091 FLD0113 FLD0137 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.993 1200 no call QD 559 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150091 FLD0113 FLD0137 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.995 0.994 1786 2534 pass pass 57211 80459 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150091 FLD0113 FLD0137 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.988 0.994 1417 2172 pass pass 42016 66432 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150110 FLD0114 FLD0138 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.549 0.486 1877 1928 pass pass 37186 32905 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150110 FLD0114 FLD0138 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.551 0.546 1719 1650 pass pass 35572 34076 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150110 FLD0114 FLD0138 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.991 0.987 1757 1752 pass pass 74795 74049 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150110 FLD0114 FLD0138 intron TP53 c.96+30G>A chr17 7579670 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579670", "IGV") low 0.101 1233 QD no call 155 EXP0116_TP53_E3 ENSG00000141510 3 of 10 65 FFPE GCCCT C/T CAGGT CMDL150110 FLD0114 FLD0138 intron TP53 c.96+22G>A chr17 7579678 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579678", "IGV") low 0.239 1142 no call QD 218 EXP0116_TP53_E3 ENSG00000141510 3 of 10 57 FFPE GGTCC C/T CAGCC CMDL150110 FLD0114 FLD0138 nonsynonymous PIK3CA c.3140A>G p.H1047R cAt/cGt chr3 178952085 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178952085", "IGV") high 0.445 0.416 3214 3478 pass pass 25604 23946 PIK3CA_Exn21_gap 25710561 ENSG00000121879 21 of 21 rs121913279, COSM776, COSM775, COSM249874, COSM94987, COSM94986 tolerated(0.11) possibly_damaging(0.529) pathogenic 28 FFPE TGCAC A/G TCATG CMDL150110 FLD0114 FLD0138 intron PTEN c.802-9T>C chr10 89720642 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720642", "IGV") low 0.008 111 no call QD 49 PTEN_E00001156315_1m ENSG00000171862 7 of 8 43 FFPE TTTTT T/C TTTTT CMDL150110 FLD0114 FLD0138 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.992 0.995 2422 2480 pass pass 85250 82172 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150110 FLD0114 FLD0138 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.994 0.991 1439 1802 pass pass 47045 59115 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150203 FLD0115 FLD0139 intron EGFR c.2284-56C>T chr7 55248930 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248930", "IGV") medium 0.136 1792 no call pass 3806 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs41323247 T:0.0038 10 FFPE ATGTG C/T CCCTC CMDL150203 FLD0115 FLD0139 intron EGFR c.2284-30C>T chr7 55248956 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248956", "IGV") low 0.109 1724 QD no call 2606 EGFR_E00001601336_1 ENSG00000146648 19 of 27 36 FFPE CGAAG C/T CACAC CMDL150203 FLD0115 FLD0139 intron EGFR c.2284-28A>G chr7 55248958 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55248958", "IGV") low 0.110 1730 QD no call 2465 EGFR_E00001601336_1 ENSG00000146648 19 of 27 38 FFPE AAGCC A/G CACTG CMDL150203 FLD0115 FLD0139 synonymous EGFR c.2352C>T c.2352C>T(p.%3D) tcC/tcT chr7 55249054 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249054", "IGV") low 0.098 1656 QD no call 1563 EGFR_E00001601336_1 ENSG00000146648 20 of 28 39 FFPE ACCTC C/T ACCGT CMDL150203 FLD0115 FLD0139 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.252 0.611 1640 1714 pass pass 11351 38743 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150203 FLD0115 FLD0139 nonsynonymous EGFR c.2369C>T p.T790M aCg/aTg chr7 55249071 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249071", "IGV") low 0.093 1714 no call QD 1269 EGFR_E00001601336_1 ENSG00000146648 20 of 28 CM054664, rs121434569, COSM6240 deleterious(0) probably_damaging(1) likely_pathogenic,drug_response,protective 22 FFPE CATCA C/T GCAGC CMDL150203 FLD0115 FLD0139 synonymous EGFR c.2382C>G c.2382C>G(p.%3D) ccC/ccG chr7 55249084 C G =hyperlink("http://localhost:60151/goto?locus=chr7:55249084", "IGV") low 0.099 1640 QD no call 1826 EGFR_E00001601336_1 ENSG00000146648 20 of 28 9 FFPE ATGCC C/G TTCGG CMDL150203 FLD0115 FLD0139 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.512 0.531 1613 1740 pass pass 30445 32314 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150203 FLD0115 FLD0139 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.521 0.481 1583 1687 pass pass 29890 27630 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150203 FLD0115 FLD0139 nonsynonymous EGFR c.2794C>T p.R932C Cgc/Tgc chr7 55266502 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266502", "IGV") high 0.378 0.427 3161 3398 pass pass 19620 26798 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(1) 50 FFPE GAGAA C/T GCCTC CMDL150203 FLD0115 FLD0139 nonsynonymous EGFR c.2794C>T p.R932C Cgc/Tgc chr7 55266502 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266502", "IGV") high 0.417 0.406 4050 4043 pass pass 30169 29180 EGFR_E00001779947_2 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(1) 26 FFPE GAGAA C/T GCCTC CMDL150203 FLD0115 FLD0139 synonymous EGFR c.2874C>T c.2874C>T(p.%3D) cgC/cgT chr7 55268034 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268034", "IGV") high 0.378 0.325 3107 3653 pass pass 19243 15549 EGFR_E00001790701_1 ENSG00000146648 24 of 28 COSM1488606 76 FFPE AGTCG C/T CCAAA CMDL150203 FLD0115 FLD0139 nonsynonymous EGFR c.3092G>A p.R1031Q cGg/cAg chr7 55269026 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269026", "IGV") high 0.356 0.361 3649 3549 pass pass 17984 19283 EGFR_E00001801208_2 ENSG00000146648 25 of 28 rs570295933, COSM3881830 tolerated(0.16) probably_damaging(0.998) A:0.0002 53 FFPE GTCAC G/A GACTC CMDL150203 FLD0115 FLD0139 intron TP53 c.96+24G>A chr17 7579676 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579676", "IGV") medium 0.310 1144 pass no call 8811 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE CAGGT C/T CCCAG CMDL150203 FLD0115 FLD0139 splice_region,intron PTEN c.634+4A>T chr10 89712020 A T =hyperlink("http://localhost:60151/goto?locus=chr10:89712020", "IGV") high 0.423 0.352 3683 3619 pass pass 29076 18902 PTEN_E00001156327_4 ENSG00000171862 6 of 8 COSM5908 30 FFPE CAGTA A/T GTGCT CMDL150203 FLD0115 FLD0139 nonsynonymous TP53 c.659A>G p.Y220C tAt/tGt chr17 7578190 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578190", "IGV") high 0.609 0.649 1984 1972 pass pass 27345 29494 TP53_E00001255919_1 25404506 ENSG00000141510 6 of 11 CM015378, CM951227, rs121912666, TP53_g.12728A>T, TP53_g.12728A>C, TP53_g.12728A>G, COSM10758, COSM43850, COSM1564197, COSM99720, COSM251427, COSM1564198, COSM251426, COSM99718, COSM1564199, COSM3355993, COSM3675523, COSM1644277, COSM3675522, COSM99719, COSM251428, COSM1564200 deleterious(0) probably_damaging(1) pathogenic 63 FFPE GCTCA T/C AGGGC CMDL150203 FLD0115 FLD0139 stop_gained TP53 c.586C>T p.R196* Cga/Tga chr17 7578263 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578263", "IGV") high 0.436 0.400 3960 4545 pass pass 33053 32612 TP53_E00001255919_3 ENSG00000141510 6 of 11 CM941329, rs397516435, TP53_g.12655del, TP53_g.12655C>G, TP53_g.12655C>A, TP53_g.12655C>T, COSM10705, COSM44757, COSM44615, COSM99668, COSM166215, COSM99665, COSM166214, COSM99666, COSM166216, COSM3378446, COSM1640847, COSM1735837, COSM99667, COSM166217 pathogenic 14 FFPE CACTC G/A GATAA CMDL150203 FLD0115 FLD0139 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") medium 0.152 1249 no call pass 3083 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150203 FLD0115 FLD0139 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") low 0.091 1077 QD no call 949 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL150203 FLD0115 FLD0139 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.993 0.996 2152 2511 pass pass 77022 93656 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150203 FLD0115 FLD0139 intron TP53 c.74+35C>T chr17 7579804 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579804", "IGV") low 0.123 2152 QD no call 436 TP53_E00001596491_1 ENSG00000141510 2 of 10 27 FFPE GTGGG G/A GTGGT CMDL150203 FLD0115 FLD0139 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") medium 0.205 2511 no call pass 6971 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL150203 FLD0115 FLD0139 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.997 0.991 1267 1208 pass pass 44461 39842 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150203 FLD0115 FLD0139 3_prime_UTR TP53 c.*41C>T chr17 7572886 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572886", "IGV") low 0.128 3256 no call QD 164 TP53_E00001757276_1 ENSG00000141510 11 of 11 17 FFPE AGATG G/A GGGTG CMDL150203 FLD0115 FLD0139 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.137 3256 no call QD 3344 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150203 FLD0115 FLD0139 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.150 3280 QD no call 3433 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150206 FLD0116 FLD0140 nonsynonymous BRAF c.1799T>A p.V600E gTg/gAg chr7 140453136 A T =hyperlink("http://localhost:60151/goto?locus=chr7:140453136", "IGV") high 0.628 0.602 3776 4164 pass pass 50436 52897 BRAF_AA_HS ENSG00000157764 15 of 18 CM112509, COSM476, COSM6137, COSM18443 deleterious(0) probably_damaging(0.967) 10 FFPE ATTTC A/T CTGTA CMDL150206 FLD0116 FLD0140 intron EGFR c.2284-37T>A chr7 55248949 T A =hyperlink("http://localhost:60151/goto?locus=chr7:55248949", "IGV") medium 0.152 1559 no call pass 3638 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs749680358 29 FFPE CACCA T/A GCGAA CMDL150206 FLD0116 FLD0140 intron EGFR c.2284-21C>T chr7 55248965 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248965", "IGV") medium 0.597 2235 pass no call 27594 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs201251727 T:0.0012 45 FFPE ACTGA C/T GTGCC CMDL150206 FLD0116 FLD0140 nonsynonymous EGFR c.2288C>T p.A763V gCc/gTc chr7 55248990 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248990", "IGV") low 0.164 3057 no call QD 1856 EGFR_E00001601336_1 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(1) 70 FFPE GGAAG C/T CTACG CMDL150206 FLD0116 FLD0140 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.990 0.987 1092 1498 pass pass 44917 63314 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150206 FLD0116 FLD0140 nonsynonymous EGFR c.2377A>G p.M793V Atg/Gtg chr7 55249079 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55249079", "IGV") medium 0.309 1092 pass no call 10164 EGFR_E00001601336_1 ENSG00000146648 20 of 28 deleterious(0.03) probably_damaging(0.998) 14 FFPE AGCTC A/G TGCCC CMDL150206 FLD0116 FLD0140 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.981 0.997 1265 1681 pass pass 59415 80392 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150206 FLD0116 FLD0140 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.995 0.997 1428 1749 pass pass 61261 75165 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150206 FLD0116 FLD0140 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.475 0.543 2975 3794 pass pass 29156 42784 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150206 FLD0116 FLD0140 intron TP53 c.97-10C>T chr17 7579600 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579600", "IGV") medium 0.403 933 pass no call 5864 EXP0116_TP53_E3 ENSG00000141510 3 of 10 24 FFPE AGATG G/A GTGAA CMDL150206 FLD0116 FLD0140 intron PTEN c.493-74A>G chr10 89711801 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89711801", "IGV") high 0.457 0.439 3080 3821 pass pass 25535 29500 PTEN_E00001156327_1 ENSG00000171862 5 of 8 6 FFPE TTACC A/G TAGCA CMDL150206 FLD0116 FLD0140 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.003 629 QD no call 386 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL150206 FLD0116 FLD0140 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.999 629 QD no call 386 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150206 FLD0116 FLD0140 nonsynonymous TP53 c.439G>A p.V147I Gtt/Att chr17 7578491 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578491", "IGV") low 0.112 2690 no call QD 519 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12427del, TP53_g.12427G>A, TP53_g.12427G>T, COSM44698, COSM43985, COSM95384, COSM437583, COSM437584, COSM437586, COSM437585 deleterious(0.01) benign(0.158) 18 FFPE ATCAA C/T CCACA CMDL150206 FLD0116 FLD0140 intron TP53 c.74+56C>T chr17 7579783 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579783", "IGV") low 0.089 535 QD no call 690 TP53_E00001596491_1 ENSG00000141510 2 of 10 6 FFPE TGCTA G/A GGGGC CMDL150206 FLD0116 FLD0140 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") medium 0.261 536 pass no call 5031 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150206 FLD0116 FLD0140 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") low 0.140 679 no call QD 178 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150206 FLD0116 FLD0140 intron TP53 c.74+35C>T chr17 7579804 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579804", "IGV") medium 0.355 1150 pass no call 7878 TP53_E00001596491_1 ENSG00000141510 2 of 10 27 FFPE GTGGG G/A GTGGT CMDL150206 FLD0116 FLD0140 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") medium 0.360 1150 pass no call 12100 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL150206 FLD0116 FLD0140 synonymous TP53 c.40C>T c.40C>T(p.%3D) Ctg/Ttg chr17 7579873 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579873", "IGV") medium 0.328 1150 pass no call 4804 TP53_E00001596491_1 ENSG00000141510 2 of 11 50 FFPE ACTCA G/A AGGGG CMDL150206 FLD0116 FLD0140 start_lost TP53 c.3G>A p.M1? atG/atA chr17 7579910 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579910", "IGV") medium 0.142 336 no call pass 877 TP53_E00001596491_1 ENSG00000141510 2 of 11 deleterious_low_confidence(0.01) probably_damaging(0.985) 13 FFPE TCCTC C/T ATGGC CMDL150206 FLD0116 FLD0140 synonymous TP53 c.270C>T c.270C>T(p.%3D) tcC/tcT chr17 7579417 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579417", "IGV") low 0.235 94 no call pass 340 TP53_E00001612188_2 ENSG00000141510 4 of 11 40 FFPE GGCCA G/A GAGGG CMDL150206 FLD0116 FLD0140 nonsynonymous TP53 c.259C>T p.P87S Cca/Tca chr17 7579428 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579428", "IGV") low 0.157 94 no call QD 141 TP53_E00001612188_2 ENSG00000141510 4 of 11 tolerated(0.36) possibly_damaging(0.45) 51 FFPE GGCTG G/A TGCAG CMDL150206 FLD0116 FLD0140 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") low 0.409 0.363 81 94 pass pass 677 571 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150206 FLD0116 FLD0140 synonymous TP53 c.717C>T c.717C>T(p.%3D) aaC/aaT chr17 7577564 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577564", "IGV") low 0.078 2206 QD no call 525 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13354C>T, TP53_g.13354C>A, TP53_g.13354C>G, TP53_g.13354del, COSM44647, COSM44510, COSM45842 48 FFPE GAACT G/A TTACA CMDL150206 FLD0116 FLD0140 synonymous TP53 c.708C>T c.708C>T(p.%3D) taC/taT chr17 7577573 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577573", "IGV") low 0.079 2206 QD no call 525 TP53_E00001665758_1 ENSG00000141510 7 of 11 CD951866, TP53_g.13345C>A, TP53_g.13345C>G, TP53_g.13345del, TP53_g.13345C>T, COSM44960, COSM43564, COSM44132, COSM1522505, COSM179815, COSM1522506, COSM179814, COSM3388192, COSM2744634, COSM1522507, COSM179816 39 FFPE CACAT G/A TAGTT CMDL150206 FLD0116 FLD0140 nonsynonymous TP53 c.701A>G p.Y234C tAc/tGc chr17 7577580 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7577580", "IGV") high 0.802 0.884 2206 2699 pass pass 48483 68576 TP53_E00001665758_1 ENSG00000141510 7 of 11 rs587780073, CM035576, TP53_g.13338A>G, TP53_g.13338A>T, TP53_g.13338A>C, COSM10725, COSM44315, COSM43865, COSM99955, COSM165073, COSM99953, COSM165072, COSM3388193, COSM1646849, COSM1646850, COSM99954, COSM165074 deleterious(0) probably_damaging(0.992) pathogenic 32 FFPE AGTTG T/C AGTGG CMDL150206 FLD0116 FLD0140 3_prime_UTR TP53 c.*42C>T chr17 7572885 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572885", "IGV") low 0.151 2625 no call QD 2053 TP53_E00001757276_1 ENSG00000141510 11 of 11 16 FFPE GAGAT G/A GGGGT CMDL150206 FLD0116 FLD0140 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.258 2077 pass no call 9643 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150206 FLD0116 FLD0140 3_prime_UTR TP53 c.*36C>T chr17 7572891 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572891", "IGV") medium 0.192 2077 pass no call 4254 TP53_E00001757276_1 ENSG00000141510 11 of 11 22 FFPE GGGGT G/A GGAGG CMDL150206 FLD0116 FLD0140 nonsynonymous TP53 c.1135C>T p.R379C Cgc/Tgc chr17 7572974 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572974", "IGV") low 0.151 2077 QD no call 1227 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs749061599 tolerated(0.17) benign(0.005) uncertain_significance 37 FFPE ATGGC G/A GGAGG CMDL150214 FLD0117 FLD0141 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.477 0.435 2017 1869 pass pass 33568 27999 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150214 FLD0117 FLD0141 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.549 0.476 1782 1639 pass pass 37257 27133 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150214 FLD0117 FLD0141 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.996 0.994 1755 1835 pass pass 74759 78171 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150214 FLD0117 FLD0141 nonsynonymous PIK3CA c.1634A>C p.E545A gAg/gCg chr3 178936092 A C =hyperlink("http://localhost:60151/goto?locus=chr3:178936092", "IGV") low 0.432 0.498 2168 2160 MQRankSum MQRankSum 16454 20956 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 rs121913274, COSM764, COSM12458, COSM27155, COSM125371, COSM297145 deleterious(0.02) probably_damaging(0.965) pathogenic 35 FFPE CACTG A/C GCAGG CMDL150214 FLD0117 FLD0141 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.014 105 LowQual,QD no call 28 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150214 FLD0117 FLD0141 intron TP53 c.74+53C>T chr17 7579786 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579786", "IGV") low 0.097 1231 QD no call 562 TP53_E00001596491_1 ENSG00000141510 2 of 10 9 FFPE TAGGG G/A GCTGG CMDL150214 FLD0117 FLD0141 intron TP53 c.74+49C>T chr17 7579790 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579790", "IGV") medium 0.112 1318 no call pass 3780 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs762400295 13 FFPE GGGCT G/A GGGTT CMDL150214 FLD0117 FLD0141 intron TP53 c.74+43C>T chr17 7579796 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579796", "IGV") low 0.085 2577 no call QD 2707 TP53_E00001596491_1 ENSG00000141510 2 of 10 19 FFPE GGGTT G/A GGGTG CMDL150214 FLD0117 FLD0141 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.991 0.995 2456 2577 pass pass 82690 89431 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150214 FLD0117 FLD0141 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.994 0.995 1598 1656 pass pass 49549 52527 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150214 FLD0117 FLD0141 splice_acceptor TP53 c.1101-2A>C chr17 7573010 T G =hyperlink("http://localhost:60151/goto?locus=chr17:7573010", "IGV") low 0.364 1501 no call QD 2199 TP53_E00001757276_1 ENSG00000141510 10 of 10 rs587781664, CS111031, TP53_g.17908A>G, TP53_g.17908A>T, TP53_g.17908A>C, COSM1191161, COSM12663, COSM45409, COSM1386548, COSM1679487 1 FFPE GTGGC T/G GTAGG CMDL150217 FLD0118 FLD0142 intron EGFR c.2284-50C>T chr7 55248936 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248936", "IGV") medium 0.296 1314 pass no call 12051 EGFR_E00001601336_1 ENSG00000146648 19 of 27 16 FFPE CCCTC C/T TTCTG CMDL150217 FLD0118 FLD0142 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.982 0.985 1282 1964 pass pass 53398 84064 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150217 FLD0118 FLD0142 nonsynonymous EGFR c.2374C>T p.L792F Ctc/Ttc chr7 55249076 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249076", "IGV") low 0.119 1282 QD no call 2077 EGFR_E00001601336_1 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(1) 17 FFPE CGCAG C/T TCATG CMDL150217 FLD0118 FLD0142 nonsynonymous EGFR c.2379G>A p.M793I atG/atA chr7 55249081 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249081", "IGV") medium 0.275 1282 pass no call 9996 EGFR_E00001601336_1 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(0.999) 12 FFPE CTCAT G/A CCCTT CMDL150217 FLD0118 FLD0142 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.992 0.991 1313 1832 pass pass 62791 86454 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150217 FLD0118 FLD0142 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.997 0.999 1398 1959 pass pass 59868 84019 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150217 FLD0118 FLD0142 intron TP53 c.97-13C>T chr17 7579603 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579603", "IGV") low 0.146 267 QD no call 283 EXP0116_TP53_E3 ENSG00000141510 3 of 10 27 FFPE TGGGT G/A AAAAG CMDL150217 FLD0118 FLD0142 intron TP53 c.97-48G>A chr17 7579638 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579638", "IGV") medium 0.214 340 no call pass 874 EXP0116_TP53_E3 ENSG00000141510 3 of 10 62 FFPE GCCCC C/T CAGCC CMDL150217 FLD0118 FLD0142 intron TP53 c.75-9G>A chr17 7579730 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579730", "IGV") low 0.087 190 no call QD 49 EXP0116_TP53_E3 ENSG00000141510 2 of 10 5 FFPE AAAGA C/T AAGAG CMDL150217 FLD0118 FLD0142 intron PTEN c.802-22T>C chr10 89720629 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720629", "IGV") medium 0.078 181 no call pass 1762 PTEN_E00001156315_1m ENSG00000171862 7 of 8 56 FFPE TTTTC T/C TTTCT CMDL150217 FLD0118 FLD0142 intron PTEN c.802-14T>C chr10 89720637 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720637", "IGV") low 0.050 181 no call QD 191 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs775342006 48 FFPE TCTTT T/C TTTTT CMDL150217 FLD0118 FLD0142 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.030 181 no call QD 317 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150217 FLD0118 FLD0142 intron PTEN c.802-9T>C chr10 89720642 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720642", "IGV") low 0.016 98 QD no call 160 PTEN_E00001156315_1m ENSG00000171862 7 of 8 43 FFPE TTTTT T/C TTTTT CMDL150217 FLD0118 FLD0142 intron PTEN c.801+136G>A chr10 89717912 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717912", "IGV") low 0.088 1743 no call QD 706 PTEN_E00001156321_4m ENSG00000171862 7 of 8 22 FFPE CATTG G/A TGAGA CMDL150217 FLD0118 FLD0142 nonsynonymous PTEN c.83T>C p.I28T aTt/aCt chr10 89653785 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89653785", "IGV") low 0.144 3116 QD no call 297 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM4016449, COSM23628 deleterious(0) possibly_damaging(0.687) 18 FFPE AGATA T/C TTATC CMDL150217 FLD0118 FLD0142 nonsynonymous PTEN c.116C>T p.A39V gCa/gTa chr10 89653818 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653818", "IGV") low 0.184 3116 QD no call 3543 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM4016451 deleterious(0.02) possibly_damaging(0.688) 51 FFPE TCCTG C/T AGAAA CMDL150217 FLD0118 FLD0142 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.079 0.100 651 1309 QD QD 206 1324 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150217 FLD0118 FLD0142 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") medium 0.127 654 pass no call 1327 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL150217 FLD0118 FLD0142 intron TP53 c.74+53C>T chr17 7579786 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579786", "IGV") medium 0.159 1310 no call pass 4664 TP53_E00001596491_1 ENSG00000141510 2 of 10 9 FFPE TAGGG G/A GCTGG CMDL150217 FLD0118 FLD0142 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.995 0.993 1290 2608 pass pass 49388 96891 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150217 FLD0118 FLD0142 nonsynonymous TP53 c.34C>T p.P12S Ccc/Tcc chr17 7579879 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579879", "IGV") low 0.137 1290 QD no call 176 TP53_E00001596491_1 ENSG00000141510 2 of 11 tolerated(0.51) possibly_damaging(0.864) 44 FFPE AGGGG G/A CTCGA CMDL150217 FLD0118 FLD0142 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.995 0.991 620 842 pass pass 20673 26346 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150217 FLD0118 FLD0142 nonsynonymous TP53 c.701A>G p.Y234C tAc/tGc chr17 7577580 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7577580", "IGV") high 0.225 0.258 2481 3475 pass pass 6788 11379 TP53_E00001665758_1 ENSG00000141510 7 of 11 rs587780073, CM035576, TP53_g.13338A>G, TP53_g.13338A>T, TP53_g.13338A>C, COSM10725, COSM44315, COSM43865, COSM99955, COSM165073, COSM99953, COSM165072, COSM3388193, COSM1646849, COSM1646850, COSM99954, COSM165074 deleterious(0) probably_damaging(0.992) pathogenic 32 FFPE AGTTG T/C AGTGG STD 1-014 FLD0119 FLD0143 nonsynonymous BRAF c.1799T>A p.V600E gTg/gAg chr7 140453136 A T =hyperlink("http://localhost:60151/goto?locus=chr7:140453136", "IGV") low 0.111 0.116 3799 3862 QD QD 342 1075 BRAF_AA_HS ENSG00000157764 15 of 18 CM112509, COSM476, COSM6137, COSM18443 deleterious(0) probably_damaging(0.967) 10 Control ATTTC A/T CTGTA STD 1-014 FLD0119 FLD0143 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.429 0.439 1929 1974 pass pass 27792 29487 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 Control GTGCA G/A CTCAT STD 1-014 FLD0119 FLD0143 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.431 0.462 1660 1620 pass pass 24342 25547 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 Control GTGCA G/A CTCAT STD 1-014 FLD0119 FLD0143 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.491 0.519 1631 1756 pass pass 28287 33165 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 Control GTGAC T/C GTTTG STD 1-014 FLD0119 FLD0143 nonsynonymous EGFR c.3046T>C p.Y1016H Tac/Cac chr7 55268980 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55268980", "IGV") low 0.171 0.157 3521 3787 QD QD 1784 470 EGFR_E00001801208_2 ENSG00000146648 25 of 28 deleterious(0) probably_damaging(0.997) 42 Control ACGAG T/C ACCTC STD 1-014 FLD0119 FLD0143 nonsynonymous KRAS c.38G>A p.G13D gGc/gAc chr12 25398281 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398281", "IGV") high 0.267 0.264 3652 3962 pass pass 12108 11962 KRAS_AA_HS ENSG00000133703 2 of 6 COSM533, COSM532, COSM534, COSM1152504, COSM1140132, COSM3384257 deleterious(0.04) possibly_damaging(0.506) 29 Control CTACG C/T CACCA STD 1-014 FLD0119 FLD0143 nonsynonymous PIK3CA c.3140A>G p.H1047R cAt/cGt chr3 178952085 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178952085", "IGV") high 0.300 0.314 3502 3753 pass pass 12473 15633 PIK3CA_Exn21_gap 25710561 ENSG00000121879 21 of 21 rs121913279, COSM776, COSM775, COSM249874, COSM94987, COSM94986 tolerated(0.11) possibly_damaging(0.529) pathogenic 28 Control TGCAC A/G TCATG STD 1-014 FLD0119 FLD0143 intron PTEN c.802-11T>C chr10 89720640 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720640", "IGV") low 0.061 0.051 557 553 QD QD 362 103 PTEN_E00001156315_1m ENSG00000171862 7 of 8 45 Control TTTTT T/C TTTTT STD 1-014 FLD0119 FLD0143 splice_region,intron TP53 c.376-7C>T chr17 7578561 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578561", "IGV") low 0.204 0.202 3450 3489 QD QD 5638 5195 TP53_E00001255919_6 ENSG00000141510 4 of 10 13 Control TGTAG G/A AAGAG STD 1-014 FLD0119 FLD0143 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.934 0.935 2046 2146 pass pass 51663 54298 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 Control GGGGT G/C GGGGT STD 1-014 FLD0119 FLD0143 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.983 0.989 1992 2025 pass pass 54390 56843 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 Control CCACG G/C GGGGA NTC_014 FLD0120 FLD0144 intron BRAF c.1742-19T>C chr7 140453212 A G =hyperlink("http://localhost:60151/goto?locus=chr7:140453212", "IGV") low 0.143 112 QD no call 122 BRAF_AA_HS ENSG00000157764 14 of 17 22 Blank AGTAA A/G GGAAA NTC_014 FLD0120 FLD0144 synonymous EGFR c.2307G>A c.2307G>A(p.%3D) gtG/gtA chr7 55249009 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249009", "IGV") low 0.342 84 pass no call 972 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs757699292, COSM1451596 84 Blank AGCGT G/A GACAA NTC_014 FLD0120 FLD0144 nonsynonymous EGFR c.2356G>A p.V786M Gtg/Atg chr7 55249058 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249058", "IGV") low 0.123 59 QD no call 88 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs762672864, COSM27110 deleterious(0) probably_damaging(0.96) 35 Blank CCACC G/A TGCAG NTC_014 FLD0120 FLD0144 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") low 0.658 59 pass no call 1300 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 Blank GTGCA G/A CTCAT NTC_014 FLD0120 FLD0144 nonsynonymous EGFR c.2324G>T p.C775F tGc/tTc chr7 55249026 G T =hyperlink("http://localhost:60151/goto?locus=chr7:55249026", "IGV") low 0.184 37 pass no call 135 EGFR_E00001601336_2 ENSG00000146648 20 of 28 COSM22954 deleterious(0) probably_damaging(0.998) 5 Blank CGTGT G/T CCGCC NTC_014 FLD0120 FLD0144 synonymous EGFR c.2343C>T c.2343C>T(p.%3D) tgC/tgT chr7 55249045 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249045", "IGV") low 0.289 37 pass no call 307 EGFR_E00001601336_2 ENSG00000146648 20 of 28 24 Blank ATCTG C/T CTCAC NTC_014 FLD0120 FLD0144 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") low 0.564 38 pass no call 752 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 Blank GTGCA G/A CTCAT NTC_014 FLD0120 FLD0144 stop_gained EGFR c.2450G>A p.W817* tGg/tAg chr7 55249152 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249152", "IGV") low 0.184 76 QD no call 131 EGFR_E00001601336_2 ENSG00000146648 20 of 28 43 Blank CAACT G/A GTGTG NTC_014 FLD0120 FLD0144 synonymous EGFR c.2466A>G c.2466A>G(p.%3D) gcA/gcG chr7 55249168 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55249168", "IGV") low 0.105 38 LowQual,QD no call 29 EGFR_E00001601336_2 ENSG00000146648 20 of 28 27 Blank ATCGC A/G AAGGT NTC_014 FLD0120 FLD0144 intron EGFR c.2469+16A>T chr7 55249187 A T =hyperlink("http://localhost:60151/goto?locus=chr7:55249187", "IGV") low 0.105 38 LowQual,QD no call 24 EGFR_E00001601336_2 ENSG00000146648 20 of 27 8 Blank AAGGG A/T GATAC NTC_014 FLD0120 FLD0144 intron EGFR c.2626-58T>C chr7 55260401 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55260401", "IGV") low 0.125 79 pass no call 162 EGFR_E00001631695_1 ENSG00000146648 21 of 27 14 Blank TAACT T/C TTTCC NTC_014 FLD0120 FLD0144 nonsynonymous EGFR c.2684G>A p.S895N aGt/aAt chr7 55260517 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260517", "IGV") low 0.100 78 QD no call 45 EGFR_E00001631695_1 ENSG00000146648 22 of 28 deleterious(0.02) probably_damaging(0.999) 36 Blank CCAGA G/A TGATG NTC_014 FLD0120 FLD0144 splice_region,intron EGFR c.2701+7C>T chr7 55260541 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260541", "IGV") low 0.088 78 QD no call 31 EGFR_E00001631695_1 ENSG00000146648 22 of 27 12 Blank TGAGT C/T ATAAT NTC_014 FLD0120 FLD0144 intron EGFR c.2470-36G>A chr7 55259376 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259376", "IGV") low 0.141 64 QD no call 118 EGFR_E00001681524_1 ENSG00000146648 20 of 27 5 Blank ATGAT G/A ATCTG NTC_014 FLD0120 FLD0144 intron EGFR c.2470-32T>C chr7 55259380 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55259380", "IGV") low 0.141 64 pass no call 164 EGFR_E00001681524_1 ENSG00000146648 20 of 27 9 Blank TGATC T/C GTCCC NTC_014 FLD0120 FLD0144 intron EGFR c.3115-41G>A chr7 55269387 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269387", "IGV") low 0.140 108 QD no call 100 EGFR_E00001773562_1 ENSG00000146648 25 of 27 33 Blank ATGTG G/A TACAA NTC_014 FLD0120 FLD0144 synonymous EGFR c.3141G>A c.3141G>A(p.%3D) gtG/gtA chr7 55269454 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269454", "IGV") medium 0.228 108 pass no call 445 EGFR_E00001773562_1 ENSG00000146648 26 of 28 41 Blank ACCGT G/A GCTTG NTC_014 FLD0120 FLD0144 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") low 1.000 38 pass no call 1546 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 Blank GTGAC T/C GTTTG NTC_014 FLD0120 FLD0144 nonsynonymous EGFR c.2758G>A p.A920T Gcc/Acc chr7 55266466 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266466", "IGV") low 0.200 78 QD no call 150 EGFR_E00001779947_1 ENSG00000146648 23 of 28 tolerated(0.38) probably_damaging(0.998) 83 Blank TCCCT G/A CCAGC NTC_014 FLD0120 FLD0144 nonsynonymous EGFR c.2809C>T p.P937S Ccc/Tcc chr7 55266517 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266517", "IGV") low 0.158 76 QD no call 41 EGFR_E00001779947_2 ENSG00000146648 23 of 28 deleterious(0.01) probably_damaging(1) 41 Blank AGCCA C/T CCATA NTC_014 FLD0120 FLD0144 intron EGFR c.2849-22T>G chr7 55267987 T G =hyperlink("http://localhost:60151/goto?locus=chr7:55267987", "IGV") low 1.000 2 no call LowQual 22 EGFR_E00001790701_1 ENSG00000146648 23 of 27 29 Blank CACTG T/G TTTTT NTC_014 FLD0120 FLD0144 intron EGFR c.2849-14C>T chr7 55267995 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55267995", "IGV") low 0.157 98 pass no call 397 EGFR_E00001790701_1 ENSG00000146648 23 of 27 37 Blank TTTCT C/T ATTCC NTC_014 FLD0120 FLD0144 intron EGFR c.2849-12T>C chr7 55267997 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55267997", "IGV") low 0.160 98 pass no call 397 EGFR_E00001790701_1 ENSG00000146648 23 of 27 39 Blank TCTCA T/C TCCTT NTC_014 FLD0120 FLD0144 synonymous EGFR c.2907C>T c.2907C>T(p.%3D) tcC/tcT chr7 55268067 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268067", "IGV") low 1.000 2 no call LowQual 22 EGFR_E00001790701_1 ENSG00000146648 24 of 28 COSM3412204, COSM3639755 47 Blank TTCTC C/T AAAAT NTC_014 FLD0120 FLD0144 synonymous EGFR c.2925C>T c.2925C>T(p.%3D) ccC/ccT chr7 55268085 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268085", "IGV") low 0.157 49 QD no call 83 EGFR_E00001790701_1 ENSG00000146648 24 of 28 rs778672343 29 Blank GACCC C/T CAGCG NTC_014 FLD0120 FLD0144 nonsynonymous EGFR c.2965T>A p.L989M Ttg/Atg chr7 55268899 T A =hyperlink("http://localhost:60151/goto?locus=chr7:55268899", "IGV") medium 0.224 146 pass no call 435 EGFR_E00001801208_1 ENSG00000146648 25 of 28 tolerated(0.06) probably_damaging(0.995) 69 Blank TGCAT T/A TGCCA NTC_014 FLD0120 FLD0144 nonsynonymous EGFR c.3014A>G p.E1005G gAa/gGa chr7 55268948 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55268948", "IGV") medium 0.250 146 pass no call 371 EGFR_E00001801208_1 ENSG00000146648 25 of 28 tolerated(0.08) benign(0.002) 20 Blank TGAAG A/G AGACA NTC_014 FLD0120 FLD0144 nonsynonymous EGFR c.3025G>A p.D1009N Gac/Aac chr7 55268959 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268959", "IGV") low 0.368 73 pass no call 828 EGFR_E00001801208_1 ENSG00000146648 25 of 28 rs148019583, COSM3639757 deleterious(0.03) possibly_damaging(0.813) 9 Blank TGGAC G/A ACGTG NTC_014 FLD0120 FLD0144 synonymous EGFR c.3018C>T c.3018C>T(p.%3D) gaC/gaT chr7 55268952 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268952", "IGV") medium 0.232 129 pass no call 400 EGFR_E00001801208_2 ENSG00000146648 25 of 28 14 Blank GAAGA C/T ATGGA NTC_014 FLD0120 FLD0144 synonymous EGFR c.3063G>A c.3063G>A(p.%3D) caG/caA chr7 55268997 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268997", "IGV") medium 0.282 133 pass no call 385 EGFR_E00001801208_2 ENSG00000146648 25 of 28 59 Blank CAGCA G/A GGCTT NTC_014 FLD0120 FLD0144 nonsynonymous EGFR c.2227G>A p.A743T Gct/Act chr7 55242457 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55242457", "IGV") low 0.138 193 QD no call 321 EGFR_Exon19 ENSG00000146648 19 of 28 rs759256622, COSM26509 deleterious(0) probably_damaging(1) 61 Blank CCGTC G/A CTATC NTC_014 FLD0120 FLD0144 synonymous TP53 c.180A>G c.180A>G(p.%3D) ccA/ccG chr17 7579507 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7579507", "IGV") low 0.115 97 pass no call 220 EXP0116_TP53_E4 ENSG00000141510 4 of 11 rs749289195, TP53_g.11411A>T, COSM43810 likely_benign 11 Blank TCATC T/C GGACC NTC_014 FLD0120 FLD0144 synonymous TP53 c.156A>G c.156A>G(p.%3D) caA/caG chr17 7579531 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7579531", "IGV") low 0.115 97 pass no call 220 EXP0116_TP53_E4 ENSG00000141510 4 of 11 TP53_g.11387A>T, COSM46177, COSM1386932, COSM1386933, COSM1386934 35 Blank AACCA T/C TGTTC NTC_014 FLD0120 FLD0144 stop_gained TP53 c.154C>T p.Q52* Caa/Taa chr17 7579533 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579533", "IGV") low 0.115 97 LowQual,QD no call 18 EXP0116_TP53_E4 ENSG00000141510 4 of 11 TP53_g.11385C>T, COSM44041, COSM99949, COSM99948, COSM3932748, COSM1750375 37 Blank CCATT G/A TTCAA NTC_014 FLD0120 FLD0144 nonsynonymous TP53 c.140C>T p.P47L cCg/cTg chr17 7579547 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579547", "IGV") low 0.231 97 pass no call 232 EXP0116_TP53_E4 ENSG00000141510 4 of 11 TP53_g.11371C>T, COSM13161, COSM44040, COSM318371, COSM318370 tolerated(0.11) benign(0.054) 51 Blank CGTCC G/A GGGAC NTC_014 FLD0120 FLD0144 synonymous TP53 c.108G>A c.108G>A(p.%3D) ccG/ccA chr17 7579579 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579579", "IGV") low 0.827 97 pass no call 2292 EXP0116_TP53_E4 18798306, 15450681, 21115003, 23570263, 17133269 ENSG00000141510 4 of 11 rs1800370, TP53_g.11339G>A, TP53_g.11339G>T benign T:0.0076 28 Blank TGGGA C/T GGCAA NTC_014 FLD0120 FLD0144 intron KRAS c.111+24A>G chr12 25398184 T C =hyperlink("http://localhost:60151/goto?locus=chr12:25398184", "IGV") low 0.128 146 LowQual,QD no call 21 KRAS_AA_HS ENSG00000133703 2 of 5 1 Blank AGTAA T/C ATGCA NTC_014 FLD0120 FLD0144 intron PTEN c.802-103A>G chr10 89720548 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89720548", "IGV") low 0.179 50 pass no call 201 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs570023843 G:0.0052 68 Blank TTGCA A/G ATGTT NTC_014 FLD0120 FLD0144 intron PTEN c.802-63T>C chr10 89720588 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720588", "IGV") low 0.140 52 QD no call 90 PTEN_E00001156315_1m ENSG00000171862 7 of 8 97 Blank AAAAA T/C AAAAC NTC_014 FLD0120 FLD0144 nonsynonymous PTEN c.836T>C p.F279S tTc/tCc chr10 89720685 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720685", "IGV") low 1.000 2 no call LowQual,MQ 22 PTEN_E00001156315_5 ENSG00000171862 8 of 9 deleterious(0) probably_damaging(0.992) 10 Blank ATTCT T/C CATAC NTC_014 FLD0120 FLD0144 synonymous PTEN c.912C>T c.912C>T(p.%3D) tgC/tgT chr10 89720761 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720761", "IGV") low 1.000 2 no call LowQual,MQ 22 PTEN_E00001156315_5 ENSG00000171862 8 of 9 COSM1349610 11 Blank ATTTG C/T AGTAT NTC_014 FLD0120 FLD0144 nonsynonymous PTEN c.899T>C p.I300T aTc/aCc chr10 89720748 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720748", "IGV") low 0.103 68 QD no call 66 PTEN_E00001156315_7 ENSG00000171862 8 of 9 tolerated(0.73) benign(0.05) 16 Blank AGAAA T/C CGATA NTC_014 FLD0120 FLD0144 intron PTEN c.1026+9A>G chr10 89720884 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89720884", "IGV") low 0.132 67 pass no call 148 PTEN_E00001156315_7 ENSG00000171862 8 of 8 12 Blank AGTTA A/G ATTAA NTC_014 FLD0120 FLD0144 intron PTEN c.635-33T>A chr10 89717577 T A =hyperlink("http://localhost:60151/goto?locus=chr10:89717577", "IGV") low 0.175 122 QD no call 155 PTEN_E00001156321_1 ENSG00000171862 6 of 8 7 Blank TCCTG T/A GAAAT NTC_014 FLD0120 FLD0144 synonymous PTEN c.699A>G c.699A>G(p.%3D) cgA/cgG chr10 89717674 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717674", "IGV") low 0.095 122 QD no call 134 PTEN_E00001156321_1 ENSG00000171862 7 of 9 COSM1561199 33 Blank ACACG A/G CGGGA NTC_014 FLD0120 FLD0144 nonsynonymous PTEN c.707A>G p.D236G gAc/gGc chr10 89717682 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717682", "IGV") low 0.095 122 QD no call 134 PTEN_E00001156321_1 ENSG00000171862 7 of 9 tolerated(0.2) benign(0.005) 25 Blank GGAAG A/G CAAGT NTC_014 FLD0120 FLD0144 synonymous PTEN c.783G>A c.783G>A(p.%3D) caG/caA chr10 89717758 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717758", "IGV") low 0.300 58 pass no call 243 PTEN_E00001156321_2 ENSG00000171862 7 of 9 rs760146269, CD972422 18 Blank AAACA G/A AACAA NTC_014 FLD0120 FLD0144 intron PTEN c.801+23G>A chr10 89717799 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717799", "IGV") low 0.289 36 pass no call 278 PTEN_E00001156321_4m ENSG00000171862 7 of 8 rs116160352 benign A:0.0008 30 Blank ATTGG G/A AGAAA NTC_014 FLD0120 FLD0144 intron PTEN c.801+41G>A chr10 89717817 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717817", "IGV") low 0.237 74 pass no call 171 PTEN_E00001156321_4m ENSG00000171862 7 of 8 48 Blank AATAA G/A GACAG NTC_014 FLD0120 FLD0144 intron PTEN c.801+150G>A chr10 89717926 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717926", "IGV") low 0.184 38 pass no call 155 PTEN_E00001156321_4m ENSG00000171862 7 of 8 8 Blank TATAA G/A GGTAA NTC_014 FLD0120 FLD0144 synonymous PTEN c.612A>G c.612A>G(p.%3D) ccA/ccG chr10 89711994 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89711994", "IGV") medium 0.508 125 pass no call 1261 PTEN_E00001156327_4 ENSG00000171862 6 of 9 rs539074063, COSM1349568 G:0.0002 56 Blank ATTCC A/G ATGTT NTC_014 FLD0120 FLD0144 intron PTEN c.634+23C>T chr10 89712039 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89712039", "IGV") low 0.091 65 LowQual,QD no call 27 PTEN_E00001156327_4 ENSG00000171862 6 of 8 11 Blank TCATC C/T TTCCA NTC_014 FLD0120 FLD0144 nonsynonymous PTEN c.271G>A p.E91K Gaa/Aaa chr10 89692787 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692787", "IGV") medium 0.225 140 pass no call 294 PTEN_E00001156330_1 ENSG00000171862 5 of 9 COSM5299, COSM5202 tolerated(0.21) benign(0.02) 20 Blank CTTTT G/A AAGAC NTC_014 FLD0120 FLD0144 synonymous PTEN c.426G>A c.426G>A(p.%3D) cgG/cgA chr10 89692942 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692942", "IGV") low 0.125 76 QD no call 73 PTEN_E00001156330_3 ENSG00000171862 5 of 9 79 Blank CATCG G/A GGCAA NTC_014 FLD0120 FLD0144 nonsynonymous PTEN c.451G>A p.A151T Gcc/Acc chr10 89692967 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692967", "IGV") low 0.125 76 pass no call 193 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5080 deleterious(0) probably_damaging(0.955) 58 Blank AAGAG G/A CCCTA NTC_014 FLD0120 FLD0144 nonsynonymous PTEN c.460T>C p.F154L Ttc/Ctc chr10 89692976 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89692976", "IGV") low 0.125 76 pass no call 193 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM1577265 tolerated(0.07) benign(0.034) 49 Blank TAGAT T/C TCTAT NTC_014 FLD0120 FLD0144 nonsynonymous PTEN c.472G>A p.V158I Gta/Ata chr10 89692988 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692988", "IGV") low 0.225 76 pass no call 189 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CM001319 tolerated(0.16) benign(0.065) 37 Blank GGGAA G/A TAAGG NTC_014 FLD0120 FLD0144 intron PTEN c.209+21G>A chr10 89685335 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89685335", "IGV") low 0.130 54 pass no call 110 PTEN_E00001156344_1 ENSG00000171862 3 of 8 4 Blank TATTT G/A TATGC NTC_014 FLD0120 FLD0144 intron PTEN c.209+23A>T chr10 89685337 A T =hyperlink("http://localhost:60151/goto?locus=chr10:89685337", "IGV") low 0.111 54 LowQual,QD no call 18 PTEN_E00001156344_1 ENSG00000171862 3 of 8 2 Blank TTTGT A/T TGCTT NTC_014 FLD0120 FLD0144 nonsynonymous PTEN c.85T>C p.Y29H Tat/Cat chr10 89653787 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89653787", "IGV") low 0.130 108 QD no call 35 PTEN_E00001156351_1 ENSG00000171862 2 of 9 tolerated(0.41) benign(0.085) 20 Blank ATATT T/C ATCCA NTC_014 FLD0120 FLD0144 nonsynonymous PTEN c.1034T>C p.L345P cTg/cCg chr10 89725051 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89725051", "IGV") medium 0.236 110 pass no call 407 PTEN_E00001456541_1 ENSG00000171862 9 of 9 CM115950, COSM5213, COSM1561193 deleterious(0) benign(0.211) 29 Blank GAAGC T/C GTACT NTC_014 FLD0120 FLD0144 nonsynonymous PTEN c.1088C>T p.T363I aCt/aTt chr10 89725105 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725105", "IGV") low 0.129 65 QD no call 116 PTEN_E00001456541_2 ENSG00000171862 9 of 9 rs750585255 tolerated(0.13) benign(0.007) 17 Blank TTCAA C/T TTCTG NTC_014 FLD0120 FLD0144 synonymous PTEN c.9C>T c.9C>T(p.%3D) gcC/gcT chr10 89624235 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624235", "IGV") medium 0.225 135 pass no call 425 PTEN_E00001456562_1 ENSG00000171862 1 of 9 COSM1561221 41 Blank ACAGC C/T ATCAT NTC_014 FLD0120 FLD0144 intron PTEN c.79+30C>T chr10 89624335 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624335", "IGV") low 0.239 69 pass no call 450 PTEN_E00001456562_1 ENSG00000171862 1 of 8 rs750009848 18 Blank CTTTA C/T CTTTC NTC_014 FLD0120 FLD0144 intron TP53 c.993+239A>T chr17 7576614 T A =hyperlink("http://localhost:60151/goto?locus=chr17:7576614", "IGV") low 0.125 110 LowQual,QD no call 29 TP53_00001404886_13 ENSG00000141510 9 of 10 7 Blank CATTT T/A CATGC NTC_014 FLD0120 FLD0144 splice_region,intron TP53 c.560-8G>A chr17 7578297 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578297", "IGV") low 0.199 128 QD no call 181 TP53_E00001255919_3 ENSG00000141510 5 of 10 rs373797299 G:0.0004 48 Blank AAGAG C/T AATCA NTC_014 FLD0120 FLD0144 intron TP53 c.560-33C>T chr17 7578322 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578322", "IGV") medium 0.353 128 pass no call 923 TP53_E00001255919_3 ENSG00000141510 5 of 10 68 Blank GCCTG G/A GGACC NTC_014 FLD0120 FLD0144 splice_region,intron TP53 c.559+6C>T chr17 7578365 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578365", "IGV") low 0.169 128 QD no call 210 TP53_E00001255919_3 ENSG00000141510 5 of 10 rs370546196 25 Blank CAGCT G/A CTCAC NTC_014 FLD0120 FLD0144 synonymous TP53 c.549A>G c.549A>G(p.%3D) tcA/tcG chr17 7578381 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578381", "IGV") low 0.156 123 QD no call 98 TP53_E00001255919_5 ENSG00000141510 5 of 11 3 Blank CTATC T/C GAGCA NTC_014 FLD0120 FLD0144 nonsynonymous TP53 c.436T>C p.W146R Tgg/Cgg chr17 7578494 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7578494", "IGV") low 0.188 123 QD no call 172 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12424T>A, TP53_g.12424T>C, TP53_g.12424T>G, COSM46219, COSM44555, COSM44553 tolerated(0.71) benign(0.405) 15 Blank AACCC A/G CAGCT NTC_014 FLD0120 FLD0144 nonsynonymous TP53 c.424C>T p.P142S Cct/Tct chr17 7578506 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578506", "IGV") medium 0.232 123 pass no call 250 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12412C>T, TP53_g.12412C>G, TP53_g.12412C>A, TP53_g.12412del, COSM45927, COSM44969, COSM44520, COSM44927 deleterious(0) probably_damaging(1) 3 Blank CACAG G/A GCAGG NTC_014 FLD0120 FLD0144 nonsynonymous TP53 c.412G>A p.A138T Gcc/Acc chr17 7578518 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578518", "IGV") low 0.140 84 LowQual,QD no call 17 TP53_E00001255919_6 25105660 ENSG00000141510 5 of 11 CM942116, rs28934875, CM983475, TP53_g.12400G>C, TP53_g.12400G>T, TP53_g.12400del, TP53_g.12400G>A, COSM44821, COSM44280, COSM11188, COSM44508, COSM129860, COSM3403284, COSM3403287, COSM129861, COSM129863, COSM3403289, COSM4139889, COSM3403286, COSM2744944, COSM3403285, COSM3403288, COSM129862 deleterious(0) probably_damaging(0.979) pathogenic 56 Blank CTTGG C/T CAGTT NTC_014 FLD0120 FLD0144 intron TP53 c.375+9C>T chr17 7579303 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579303", "IGV") low 0.840 50 pass no call 861 TP53_E00001612188_1 ENSG00000141510 4 of 10 24 Blank TCAGG G/A CAACT NTC_014 FLD0120 FLD0144 synonymous TP53 c.285T>C c.285T>C(p.%3D) tcT/tcC chr17 7579402 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7579402", "IGV") low 1.000 2 no call LowQual 22 TP53_E00001612188_1 ENSG00000141510 4 of 11 4 Blank ACAGA A/G GATGA NTC_014 FLD0120 FLD0144 nonsynonymous TP53 c.268T>C p.S90P Tcc/Ccc chr17 7579419 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7579419", "IGV") low 1.000 2 no call LowQual 22 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11499del, COSM1735384, COSM1735385, COSM1735387, COSM1735386 tolerated(0.42) benign(0.005) 42 Blank CCAGG A/G GGGGG NTC_014 FLD0120 FLD0144 nonsynonymous TP53 c.236C>T p.A79V gCt/gTt chr17 7579451 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579451", "IGV") low 1.000 2 no call pass 63 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11467C>T, TP53_g.11467C>G, COSM1386917, COSM45590, COSM1386920, COSM1386918, COSM1386921, COSM1386919 tolerated(0.29) benign(0.009) 50 Blank TAGGA G/A CTGCT NTC_014 FLD0120 FLD0144 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") low 1.000 1.000 2 2 pass pass 63 63 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 Blank CCACG G/C GGGGA NTC_014 FLD0120 FLD0144 nonsynonymous TP53 c.214C>T p.P72S Ccc/Tcc chr17 7579473 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579473", "IGV") low 1.000 2 pass no call 63 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11445C>T, TP53_g.11445del, COSM44256, COSM44018, COSM4070066, COSM4070069, COSM4070068, COSM4070067 tolerated(0.8) benign(0.002) 28 Blank CACGG G/A GGGAG NTC_014 FLD0120 FLD0144 intron TP53 c.782+14T>C chr17 7577485 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7577485", "IGV") low 0.571 56 pass no call 1243 TP53_E00001665758_1 ENSG00000141510 7 of 10 36 Blank GTGGC A/G AGTGG NTC_014 FLD0120 FLD0144 nonsynonymous TP53 c.773A>T p.E258V gAa/gTa chr17 7577508 T A =hyperlink("http://localhost:60151/goto?locus=chr17:7577508", "IGV") low 0.571 56 pass no call 1243 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13410A>G, TP53_g.13410A>C, TP53_g.13410A>T, COSM44168, COSM44719, COSM44450, COSM1268361, COSM1564205, COSM1564206, COSM1268362 deleterious(0) probably_damaging(0.998) 59 Blank AGTCT T/A CCAGT NTC_014 FLD0120 FLD0144 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.907 98 pass no call 2185 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 Blank ATGGG G/A GTGGG NTC_014 FLD0120 FLD0144 stop_gained TP53 c.1141A>T p.K381* Aaa/Taa chr17 7572968 T A =hyperlink("http://localhost:60151/goto?locus=chr17:7572968", "IGV") low 0.290 98 pass no call 441 TP53_E00001757276_1 ENSG00000141510 11 of 11 TP53_g.17950del, COSM45874 43 Blank TTTTT T/A ATGGC NTC_014 FLD0120 FLD0144 splice_acceptor TP53 c.1101-2A>C chr17 7573010 T G =hyperlink("http://localhost:60151/goto?locus=chr17:7573010", "IGV") low 0.481 50 pass no call 839 TP53_E00001757276_1 ENSG00000141510 10 of 10 rs587781664, CS111031, TP53_g.17908A>G, TP53_g.17908A>T, TP53_g.17908A>C, COSM1191161, COSM12663, COSM45409, COSM1386548, COSM1679487 1 Blank GTGGC T/G GTAGG NTC_014 FLD0120 FLD0144 intron TP53 c.993+12T>C chr17 7576841 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7576841", "IGV") medium 0.985 127 pass no call 3379 TP53_E00001789298_1 22829934 ENSG00000141510 9 of 10 rs1800899 benign G:0.0162 35 Blank GTCCC A/G AGACT NTC_014 FLD0120 FLD0144 intron TP53 c.920-11C>T chr17 7576937 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576937", "IGV") low 0.877 62 pass no call 2245 TP53_E00001789298_1 ENSG00000141510 8 of 10 27 Blank AAAGA G/A GCAAG NTC_014 FLD0120 FLD0144 intron TP53 c.920-35T>C chr17 7576961 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7576961", "IGV") low 0.200 62 pass no call 294 TP53_E00001789298_1 ENSG00000141510 8 of 10 rs540819675 3 Blank AGTGA A/G TCTGA NTC_014 FLD0120 FLD0144 splice_region,intron TP53 c.920-4C>T chr17 7576930 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576930", "IGV") low 0.197 117 QD no call 201 TP53_E00001789298_2 ENSG00000141510 8 of 10 5 Blank TGCTA G/A GAAAG NTC_014 FLD0120 FLD0144 intron TP53 c.920-44T>C chr17 7576970 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7576970", "IGV") low 0.148 117 LowQual,QD no call 23 TP53_E00001789298_2 ENSG00000141510 8 of 10 45 Blank GAGGC A/G TAACT NTC_014 FLD0120 FLD0144 splice_region,intron TP53 c.919+4A>G chr17 7577015 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7577015", "IGV") low 0.180 117 QD no call 166 TP53_E00001789298_2 ENSG00000141510 8 of 10 41 Blank CTTGC T/C TACCT NTC_014 FLD0120 FLD0144 nonsynonymous TP53 c.880G>A p.E294K Gag/Aag chr17 7577058 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577058", "IGV") low 0.300 95 pass no call 557 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13860G>C, TP53_g.13860G>T, TP53_g.13860G>A, TP53_g.13860del, COSM10856, COSM44127, COSM6621, COSM45824, COSM126981, COSM318363, COSM3388169, COSM2744501 tolerated(0.4) benign(0.179) 36 Blank AGGCT C/T CCCTT NTC_014 FLD0120 FLD0144 nonsynonymous TP53 c.856G>A p.E286K Gaa/Aaa chr17 7577082 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577082", "IGV") low 0.320 95 pass no call 940 TP53_E00001789298_3 ENSG00000141510 8 of 11 CM076567, TP53_g.13836G>C, TP53_g.13836del, TP53_g.13836G>T, TP53_g.13836G>A, COSM44250, COSM10726, COSM43919, COSM45277, COSM99924, COSM1480057, COSM318163, COSM3522693, COSM1645467, COSM1649346 deleterious(0) probably_damaging(0.982) 60 Blank CTCTT C/T CTCTG NTC_014 FLD0120 FLD0144 nonsynonymous TP53 c.841G>A p.D281N Gac/Aac chr17 7577097 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577097", "IGV") low 0.320 95 pass no call 607 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs764146326, CM076566, TP53_g.13821G>T, TP53_g.13821G>A, TP53_g.13821G>C, COSM11516, COSM43596, COSM10943, COSM146336, COSM214193, COSM1158315, COSM3388352, COSM3932743, COSM3820706, COSM2152580, COSM1649341, COSM1646814 deleterious(0.01) probably_damaging(0.996) 70 Blank CCGGT C/T TCTCC CMDL140093 FLD0193 FLD0217 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.591 0.338 1825 2156 pass pass 39275 22855 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 BC GTGCA G/A CTCAT CMDL140093 FLD0193 FLD0217 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.434 0.520 2119 2646 pass pass 31215 48848 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 BC GTGCA G/A CTCAT CMDL140093 FLD0193 FLD0217 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.580 0.490 2307 2735 pass pass 49364 47640 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 BC GTGAC T/C GTTTG CMDL140093 FLD0193 FLD0217 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.010 116 QD no call 72 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 BC CTTTT T/C TTTTT CMDL140093 FLD0193 FLD0217 5_prime_UTR PTEN c.-11G>A chr10 89624216 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624216", "IGV") low 0.103 2065 QD no call 1910 PTEN_E00001456562_1 ENSG00000171862 1 of 9 rs756632919 22 BC CCACA G/A GCTCC CMDL140093 FLD0193 FLD0217 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.994 0.995 2799 3467 pass pass 77565 97698 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 BC GGGGT G/C GGGGT CMDL140093 FLD0193 FLD0217 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.993 0.997 2949 3860 pass pass 81819 111756 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 BC CCACG G/C GGGGA CMDL140095 FLD0194 FLD0218 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.599 0.516 1915 1993 pass pass 42193 36394 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 BC GTGCA G/A CTCAT CMDL140095 FLD0194 FLD0218 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.489 0.519 2312 2343 pass pass 38810 43184 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 BC GTGCA G/A CTCAT CMDL140095 FLD0194 FLD0218 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.445 0.549 2585 2449 pass pass 40028 49026 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 BC GTGAC T/C GTTTG CMDL140095 FLD0194 FLD0218 intron PTEN c.802-10T>C chr10 89720641 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720641", "IGV") low 0.007 145 no call LowQual,QD 29 PTEN_E00001156315_1m ENSG00000171862 7 of 8 44 BC TTTTT T/C TTTTT CMDL140095 FLD0194 FLD0218 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.991 0.991 3049 3391 pass pass 84338 93824 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 BC GGGGT G/C GGGGT CMDL140095 FLD0194 FLD0218 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.996 0.995 3373 3697 pass pass 92408 104503 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 BC CCACG G/C GGGGA CMDL140097 FLD0195 FLD0219 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.986 0.988 2124 1796 pass pass 88102 75009 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 BC GTGCA G/A CTCAT CMDL140097 FLD0195 FLD0219 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.994 0.993 2455 2319 pass pass 108694 101018 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 BC GTGCA G/A CTCAT CMDL140097 FLD0195 FLD0219 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.998 0.997 2480 2335 pass pass 105629 99162 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 BC GTGAC T/C GTTTG CMDL140099 FLD0196 FLD0220 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.548 0.487 1902 1821 pass pass 37103 30677 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 BC GTGCA G/A CTCAT CMDL140099 FLD0196 FLD0220 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.498 0.488 2243 2188 pass pass 38478 36923 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 BC GTGCA G/A CTCAT CMDL140099 FLD0196 FLD0220 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.998 0.997 2279 2242 pass pass 96751 95174 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 BC GTGAC T/C GTTTG CMDL140099 FLD0196 FLD0220 synonymous EGFR c.3015A>G c.3015A>G(p.%3D) gaA/gaG chr7 55268949 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55268949", "IGV") high 0.534 0.505 5271 5258 pass pass 54951 50044 EGFR_E00001801208_1 ENSG00000146648 25 of 28 rs55737335 G:0.0014 19 BC GAAGA A/G GACAT CMDL140099 FLD0196 FLD0220 synonymous EGFR c.3015A>G c.3015A>G(p.%3D) gaA/gaG chr7 55268949 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55268949", "IGV") high 0.518 0.537 2845 2721 pass pass 51824 51489 EGFR_E00001801208_2 ENSG00000146648 25 of 28 rs55737335 G:0.0014 11 BC GAAGA A/G GACAT CMDL140099 FLD0196 FLD0220 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.990 0.994 3009 3014 pass pass 84212 84923 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 BC GGGGT G/C GGGGT CMDL140099 FLD0196 FLD0220 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.994 0.996 3418 3264 pass pass 96999 92455 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 BC CCACG G/C GGGGA CMDL140197 FLD0197 FLD0221 nonsynonymous BRAF c.1750C>T p.L584F Ctt/Ttt chr7 140453185 G A =hyperlink("http://localhost:60151/goto?locus=chr7:140453185", "IGV") medium 0.607 3198 pass no call 40084 BRAF_AA_HS ENSG00000157764 15 of 18 COSM28010 deleterious(0.01) probably_damaging(0.968) 49 FFPE ATGAA G/A AAATA CMDL140197 FLD0197 FLD0221 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.995 0.789 1832 2284 pass pass 80856 70488 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140197 FLD0197 FLD0221 nonsynonymous EGFR c.2506C>T p.R836C Cgc/Tgc chr7 55259448 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259448", "IGV") medium 0.398 4634 pass no call 30849 EGFR_E00001681524_1 ENSG00000146648 21 of 28 rs374952732, COSM53227, COSM28604 deleterious(0) probably_damaging(0.999) 77 FFPE TGCAC C/T GCGAC CMDL140197 FLD0197 FLD0221 synonymous EGFR c.2571G>A c.2571G>A(p.%3D) ggG/ggA chr7 55259513 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259513", "IGV") medium 0.186 2319 pass no call 9118 EGFR_E00001681524_1 ENSG00000146648 21 of 28 13 FFPE TTTGG G/A CTGGC CMDL140197 FLD0197 FLD0221 synonymous EGFR c.2574G>A c.2574G>A(p.%3D) ctG/ctA chr7 55259516 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259516", "IGV") low 0.117 2319 QD no call 3460 EGFR_E00001681524_1 ENSG00000146648 21 of 28 rs397517129, COSM133590 uncertain_significance 10 FFPE GGGCT G/A GCCAA CMDL140197 FLD0197 FLD0221 synonymous EGFR c.2512C>T c.2512C>T(p.%3D) Ctg/Ttg chr7 55259454 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259454", "IGV") medium 0.251 3047 no call pass 9111 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM3366979, COSM13426 38 FFPE GCGAC C/T TGGCA CMDL140197 FLD0197 FLD0221 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") medium 1.000 0.400 1119 5 pass pass 47630 42 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140197 FLD0197 FLD0221 nonsynonymous EGFR c.3055C>T p.P1019S Cca/Tca chr7 55268989 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268989", "IGV") medium 0.402 4288 pass no call 35334 EGFR_E00001801208_2 ENSG00000146648 25 of 28 deleterious(0) probably_damaging(0.994) 51 FFPE TCATC C/T CACAG CMDL140197 FLD0197 FLD0221 nonsynonymous EGFR c.3056C>T p.P1019L cCa/cTa chr7 55268990 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268990", "IGV") medium 0.405 4288 pass no call 64225 EGFR_E00001801208_2 ENSG00000146648 25 of 28 COSM747423 deleterious(0) probably_damaging(0.998) 52 FFPE CATCC C/T ACAGC CMDL140197 FLD0197 FLD0221 splice_region,synonymous EGFR c.3112C>T c.3112C>T(p.%3D) Ctg/Ttg chr7 55269046 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269046", "IGV") medium 0.483 5015 no call pass 45278 EGFR_E00001801208_2 ENSG00000146648 25 of 28 rs138104726 33 FFPE GCTCT C/T TGGTA CMDL140197 FLD0197 FLD0221 intron EGFR c.3114+26C>T chr7 55269074 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269074", "IGV") medium 0.402 3772 pass no call 25314 EGFR_E00001801208_2 ENSG00000146648 25 of 27 5 FFPE TCTCT C/T TCTCA CMDL140197 FLD0197 FLD0221 nonsynonymous EGFR c.2236G>A p.E746K Gaa/Aaa chr7 55242466 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55242466", "IGV") medium 0.402 5091 no call pass 35176 EGFR_Exon19 ENSG00000146648 19 of 28 rs121913427, COSM13184 deleterious(0.01) probably_damaging(0.99) not_provided 52 FFPE TCAAG G/A AATTA CMDL140197 FLD0197 FLD0221 splice_region,intron TP53 c.96+5G>A chr17 7579695 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579695", "IGV") medium 0.820 144 pass no call 2649 EXP0116_TP53_E3 ENSG00000141510 3 of 10 40 FFPE TTGTC C/T TTACC CMDL140197 FLD0197 FLD0221 splice_acceptor TP53 c.97-1G>A chr17 7579591 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579591", "IGV") medium 0.457 5150 no call pass 43158 EXP0116_TP53_E4 ENSG00000141510 3 of 10 CS971912, TP53_g.11327G>A, TP53_g.11327G>C, COSM43759, COSM29761, COSM1610880, COSM437642, COSM218543, COSM1610881, COSM437643, COSM218542, COSM1610882, COSM3388237, COSM3717685, COSM3717684, COSM2745172 16 FFPE GGGGA C/T TGTAG CMDL140197 FLD0197 FLD0221 nonsynonymous PTEN c.928G>A p.D310N Gat/Aat chr10 89720777 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720777", "IGV") medium 0.418 4869 pass no call 34086 PTEN_E00001156315_7 ENSG00000171862 8 of 9 tolerated(0.13) benign(0.31) 45 FFPE GTGCA G/A ATAAT CMDL140197 FLD0197 FLD0221 nonsynonymous PTEN c.692C>T p.P231L cCc/cTc chr10 89717667 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717667", "IGV") medium 0.578 2199 no call pass 25590 PTEN_E00001156321_2 ENSG00000171862 7 of 9 tolerated(0.29) benign(0.002) 28 FFPE AGGAC C/T CACAC CMDL140197 FLD0197 FLD0221 stop_gained PTEN c.697C>T p.R233* Cga/Tga chr10 89717672 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717672", "IGV") medium 0.471 3999 pass no call 35136 PTEN_E00001156321_2 ENSG00000171862 7 of 9 CM971277, rs121909219, COSM5154, COSM69004, COSM13457, COSM33990 pathogenic 33 FFPE CCACA C/T GACGG CMDL140197 FLD0197 FLD0221 synonymous PTEN c.793C>T c.793C>T(p.%3D) Cta/Tta chr10 89717768 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717768", "IGV") low 0.577 2197 no call FS 13416 PTEN_E00001156321_2 ENSG00000171862 7 of 9 8 FFPE AGATG C/T TAAAA CMDL140197 FLD0197 FLD0221 nonsynonymous PTEN c.517C>T p.R173C Cgc/Tgc chr10 89711899 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711899", "IGV") medium 0.692 3497 no call pass 53478 PTEN_E00001156327_1 ENSG00000171862 6 of 9 CM074467, rs121913293, COSM5089, COSM5825 deleterious(0.02) probably_damaging(0.913) pathogenic 19 FFPE AGAGG C/T GCTAT CMDL140197 FLD0197 FLD0221 nonsynonymous PTEN c.601G>A p.E201K Gaa/Aaa chr10 89711983 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89711983", "IGV") medium 0.945 3776 pass no call 100847 PTEN_E00001156327_4 ENSG00000171862 6 of 9 COSM921114 tolerated(0.06) benign(0.009) 67 FFPE TGTTT G/A AAACT CMDL140197 FLD0197 FLD0221 splice_region,intron PTEN c.253+4G>A chr10 89690850 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89690850", "IGV") low 0.177 3318 QD no call 5125 PTEN_E00001156337_4 ENSG00000171862 4 of 8 42 FFPE AGGTA G/A GTATG CMDL140197 FLD0197 FLD0221 splice_region,intron PTEN c.253+5G>A chr10 89690851 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89690851", "IGV") medium 0.176 3318 pass no call 14979 PTEN_E00001156337_4 ENSG00000171862 4 of 8 COSM24686 43 FFPE GGTAG G/A TATGA CMDL140197 FLD0197 FLD0221 intron PTEN c.164+18T>C chr10 89653884 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89653884", "IGV") low 0.333 4 no call pass 50 PTEN_E00001156351_1 ENSG00000171862 2 of 8 13 FFPE TGATT T/C TCTAT CMDL140197 FLD0197 FLD0221 intron PTEN c.164+19T>C chr10 89653885 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89653885", "IGV") low 0.333 4 no call pass 50 PTEN_E00001156351_1 ENSG00000171862 2 of 8 12 FFPE GATTT T/C CTATT CMDL140197 FLD0197 FLD0221 nonsynonymous,splice_region PTEN c.1028T>C p.V343A gTg/gCg chr10 89725045 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89725045", "IGV") low 1.000 2 no call LowQual 22 PTEN_E00001456541_1 ENSG00000171862 9 of 9 CM971279, COSM1684699 deleterious(0.02) probably_damaging(0.993) 23 FFPE CTAGG T/C GAAGC CMDL140197 FLD0197 FLD0221 nonsynonymous PTEN c.1180G>A p.E394K Gaa/Aaa chr10 89725197 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725197", "IGV") medium 0.325 3746 no call pass 16521 PTEN_E00001456541_2 ENSG00000171862 9 of 9 deleterious_low_confidence(0.02) benign(0.272) 44 FFPE TTGAT G/A AAGAT CMDL140197 FLD0197 FLD0221 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 1.000 418 pass no call 17638 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140197 FLD0197 FLD0221 intron TP53 c.559+32C>T chr17 7578339 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578339", "IGV") medium 0.315 5299 no call pass 25455 TP53_E00001255919_3 ENSG00000141510 5 of 10 rs748298015 51 FFPE AACCA G/A CCCTG CMDL140197 FLD0197 FLD0221 5_prime_UTR TP53 c.-2C>T chr17 7579914 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579914", "IGV") medium 0.750 559 no call pass 15924 TP53_E00001596491_1 ENSG00000141510 2 of 11 9 FFPE CCATG G/A CAGTG CMDL140197 FLD0197 FLD0221 nonsynonymous TP53 c.368C>T p.T123I aCt/aTt chr17 7579319 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579319", "IGV") medium 0.297 3794 no call pass 15050 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11599C>T, TP53_g.11599C>A, COSM44188 deleterious(0.03) possibly_damaging(0.733) 40 FFPE TGCAA G/A TCACA CMDL140197 FLD0197 FLD0221 nonsynonymous TP53 c.292C>T p.P98S Cct/Tct chr17 7579395 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579395", "IGV") medium 0.599 2469 pass no call 29751 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11523C>T, COSM12296, COSM1386881, COSM1386882 deleterious(0) probably_damaging(1) 11 FFPE GGAAG G/A GACAG CMDL140197 FLD0197 FLD0221 synonymous TP53 c.291C>T c.291C>T(p.%3D) gtC/gtT chr17 7579396 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579396", "IGV") medium 0.652 3794 no call pass 53164 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11522C>T, COSM473435, COSM473436, COSM473437 10 FFPE GAAGG G/A ACAGA CMDL140197 FLD0197 FLD0221 synonymous TP53 c.267C>T c.267C>T(p.%3D) ccC/ccT chr17 7579420 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579420", "IGV") medium 0.266 285 pass no call 1115 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs587783062, TP53_g.11498C>T, TP53_g.11498del, COSM1268330, COSM1180853, COSM1180854 likely_pathogenic 43 FFPE CAGGA G/A GGGGC CMDL140197 FLD0197 FLD0221 nonsynonymous TP53 c.223C>T p.P75S Cct/Tct chr17 7579464 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579464", "IGV") medium 0.506 1652 no call pass 19232 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11454C>T, TP53_g.11454del, COSM44803, COSM46193 tolerated(0.81) benign(0.009) 37 FFPE TGCAG G/A GGCCA CMDL140197 FLD0197 FLD0221 synonymous TP53 c.222C>T c.222C>T(p.%3D) gcC/gcT chr17 7579465 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579465", "IGV") medium 0.503 1652 no call pass 19019 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11453C>T, COSM46098 36 FFPE GCAGG G/A GCCAC CMDL140197 FLD0197 FLD0221 nonsynonymous TP53 c.212C>T p.P71L cCc/cTc chr17 7579475 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579475", "IGV") medium 0.502 1652 no call pass 19092 TP53_E00001612188_2 ENSG00000141510 4 of 11 tolerated(0.57) benign(0.004) 26 FFPE CGGGG G/A GAGCA CMDL140197 FLD0197 FLD0221 nonsynonymous TP53 c.742C>T p.R248W Cgg/Tgg chr17 7577539 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577539", "IGV") high 0.678 0.418 2307 3501 pass pass 34388 26285 TP53_E00001665758_1 ENSG00000141510 7 of 11 CM010465, CM900211, rs121912651, TP53_g.13379C>G, TP53_g.13379C>T, TP53_g.13379C>A, TP53_g.13379del, COSM11564, COSM45116, COSM10656, COSM44920, COSM120007, COSM1189381, COSM120005, COSM1189382, COSM3388183, COSM1640831, COSM120006, COSM1189383 deleterious(0) probably_damaging(1) pathogenic 73 FFPE CCTCC G/A GTTCA CMDL140197 FLD0197 FLD0221 nonsynonymous TP53 c.1039G>A p.A347T Gcc/Acc chr17 7573988 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573988", "IGV") medium 0.308 3649 no call pass 14516 TP53_E00001728015_1 ENSG00000141510 10 of 11 TP53_g.16930G>C, TP53_g.16930G>A, COSM45717, COSM1191612 deleterious(0) probably_damaging(0.98) 49 FFPE CAAGG C/T CTCAT CMDL140197 FLD0197 FLD0221 nonsynonymous TP53 c.998G>A p.R333H cGt/cAt chr17 7574029 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7574029", "IGV") medium 0.345 1755 no call pass 21011 TP53_E00001728015_1 ENSG00000141510 10 of 11 rs573154688 tolerated(0.19) benign(0.178) uncertain_significance T:0.0002 8 FFPE GCCCA C/T GGATC CMDL140197 FLD0197 FLD0221 intron TP53 c.919+36A>G chr17 7576983 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7576983", "IGV") medium 0.424 1175 no call pass 8730 TP53_E00001789298_2 ENSG00000141510 8 of 10 58 FFPE ACCCT T/C GGTCT CMDL140197 FLD0197 FLD0221 intron TP53 c.919+22C>T chr17 7576997 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576997", "IGV") medium 0.985 1175 no call pass 32557 TP53_E00001789298_2 ENSG00000141510 8 of 10 rs549731874, TP53_g.13921C>T A:0.0002 59 FFPE CCACC G/A CTTCT CMDL140197 FLD0197 FLD0221 nonsynonymous TP53 c.889C>T p.H297Y Cac/Tac chr17 7577049 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577049", "IGV") medium 0.991 1175 no call pass 33055 TP53_E00001789298_2 ENSG00000141510 8 of 11 TP53_g.13869C>A, TP53_g.13869C>T, TP53_g.13869C>G, COSM45803, COSM45693 deleterious(0.02) benign(0.036) 7 FFPE CTCGT G/A GTGAG CMDL140197 FLD0197 FLD0221 synonymous TP53 c.906G>A c.906G>A(p.%3D) ggG/ggA chr17 7577032 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577032", "IGV") medium 0.130 1963 no call pass 4496 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13886del, TP53_g.13886G>T, TP53_g.13886G>C, COSM46318, COSM45998, COSM45177 10 FFPE GTGCT C/T CCTGG CMDL140197 FLD0197 FLD0221 synonymous TP53 c.793C>T c.793C>T(p.%3D) Ctg/Ttg chr17 7577145 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577145", "IGV") low 0.195 3879 no call QD 4483 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13773C>A, TP53_g.13773C>T, TP53_g.13773del, COSM44984, COSM45393, COSM44293, COSM3388177, COSM3388179, COSM3388178 22 FFPE TCCCA G/A TAGAT CMDL140201 FLD0198 FLD0222 nonsynonymous BRAF c.1766C>T p.T589I aCa/aTa chr7 140453169 G A =hyperlink("http://localhost:60151/goto?locus=chr7:140453169", "IGV") low 0.160 5730 QD no call 3416 BRAF_AA_HS ENSG00000157764 15 of 18 COSM21493 deleterious(0) probably_damaging(0.978) 43 FFPE TTACT G/A TGAGG CMDL140201 FLD0198 FLD0222 intron EGFR c.2284-39C>T chr7 55248947 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248947", "IGV") medium 0.136 472 pass no call 984 EGFR_E00001601336_1 ENSG00000146648 19 of 27 27 FFPE GCCAC C/T ATGCG CMDL140201 FLD0198 FLD0222 intron EGFR c.2284-21C>T chr7 55248965 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248965", "IGV") medium 0.852 3204 no call pass 65027 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs201251727 T:0.0012 45 FFPE ACTGA C/T GTGCC CMDL140201 FLD0198 FLD0222 nonsynonymous EGFR c.2293G>A p.V765M Gtg/Atg chr7 55248995 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55248995", "IGV") medium 0.592 911 pass no call 11824 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs374873413, COSM28603 deleterious(0.02) probably_damaging(0.997) 75 FFPE CCTAC G/A TGATG CMDL140201 FLD0198 FLD0222 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.984 0.988 439 1581 pass pass 18513 66549 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140201 FLD0198 FLD0222 nonsynonymous EGFR c.2344C>T p.L782F Ctc/Ttc chr7 55249046 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249046", "IGV") medium 0.631 2405 no call pass 57584 EGFR_E00001601336_2 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(0.993) 25 FFPE TCTGC C/T TCACC CMDL140201 FLD0198 FLD0222 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.993 0.992 2168 2514 pass pass 119861 108245 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140201 FLD0198 FLD0222 intron EGFR c.2469+10G>A chr7 55249181 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249181", "IGV") low 0.110 1935 QD no call 1838 EGFR_E00001601336_2 ENSG00000146648 20 of 27 14 FFPE TCAGG G/A AAGGG CMDL140201 FLD0198 FLD0222 stop_gained EGFR c.2693G>A p.W898* tGg/tAg chr7 55260526 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260526", "IGV") low 0.085 2537 QD no call 404 EGFR_E00001631695_1 ENSG00000146648 22 of 28 27 FFPE TGTCT G/A GAGCT CMDL140201 FLD0198 FLD0222 splice_region,intron EGFR c.2701+5G>A chr7 55260539 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260539", "IGV") medium 0.160 2917 no call pass 8924 EGFR_E00001631695_1 ENSG00000146648 22 of 27 14 FFPE GGTGA G/A TCATA CMDL140201 FLD0198 FLD0222 intron EGFR c.2470-25C>T chr7 55259387 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259387", "IGV") medium 0.130 2427 pass no call 5242 EGFR_E00001681524_1 ENSG00000146648 20 of 27 16 FFPE TCCCT C/T ACAGC CMDL140201 FLD0198 FLD0222 nonsynonymous EGFR c.2614G>A p.E872K Gaa/Aaa chr7 55259556 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259556", "IGV") low 0.112 1499 QD no call 674 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM133589, COSM18487 deleterious(0) probably_damaging(0.947) 16 FFPE ATGCA G/A AAGGA CMDL140201 FLD0198 FLD0222 nonsynonymous EGFR c.2620G>A p.G874S Ggc/Agc chr7 55259562 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259562", "IGV") low 0.111 2051 no call QD 2266 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM26438 deleterious(0.01) probably_damaging(0.986) 10 FFPE AAGGA G/A GCAAA CMDL140201 FLD0198 FLD0222 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.997 0.998 2236 2503 pass pass 95272 106612 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140201 FLD0198 FLD0222 intron EGFR c.2849-41C>T chr7 55267968 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55267968", "IGV") medium 0.207 1909 pass no call 9711 EGFR_E00001790701_1 ENSG00000146648 23 of 27 10 FFPE TCTTC C/T AGTGT CMDL140201 FLD0198 FLD0222 splice_region,intron EGFR c.2849-3C>T chr7 55268006 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268006", "IGV") medium 0.209 3891 pass no call 8079 EGFR_E00001790701_1 ENSG00000146648 23 of 27 48 FFPE TTCCC C/T AGGCT CMDL140201 FLD0198 FLD0222 synonymous EGFR c.2922C>T c.2922C>T(p.%3D) gaC/gaT chr7 55268082 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268082", "IGV") low 0.150 2433 no call QD 3870 EGFR_E00001790701_1 ENSG00000146648 24 of 28 32 FFPE CGAGA C/T CCCCA CMDL140201 FLD0198 FLD0222 splice_region,synonymous EGFR c.2949G>A c.2949G>A(p.%3D) ggG/ggA chr7 55268883 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268883", "IGV") low 0.179 6054 no call QD 2566 EGFR_E00001801208_1 ENSG00000146648 25 of 28 59 FFPE CAGGG G/A GATGA CMDL140201 FLD0198 FLD0222 intron TP53 c.97-13C>T chr17 7579603 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579603", "IGV") low 0.199 651 QD no call 1290 EXP0116_TP53_E3 ENSG00000141510 3 of 10 27 FFPE TGGGT G/A AAAAG CMDL140201 FLD0198 FLD0222 nonsynonymous TP53 c.91G>A p.V31I Gtt/Att chr17 7579705 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579705", "IGV") low 0.188 1072 no call QD 1144 EXP0116_TP53_E3 ENSG00000141510 3 of 11 rs201753350, CM074603, TP53_g.11213G>A, COSM45360, COSM1717726, COSM1717728, COSM1717727, COSM1717729 tolerated(0.24) benign(0.002) uncertain_significance,not_provided,likely_benign T:0.0018 30 FFPE CAGAA C/T GTTGT CMDL140201 FLD0198 FLD0222 stop_gained TP53 c.154C>T p.Q52* Caa/Taa chr17 7579533 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579533", "IGV") medium 0.209 4099 no call pass 10214 EXP0116_TP53_E4 ENSG00000141510 4 of 11 TP53_g.11385C>T, COSM44041, COSM99949, COSM99948, COSM3932748, COSM1750375 37 FFPE CCATT G/A TTCAA CMDL140201 FLD0198 FLD0222 intron PTEN c.802-130G>A chr10 89720521 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720521", "IGV") low 0.118 2155 no call QD 3876 PTEN_E00001156315_1m ENSG00000171862 7 of 8 41 FFPE CAAAT G/A ATAGT CMDL140201 FLD0198 FLD0222 intron PTEN c.635-37C>T chr10 89717573 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717573", "IGV") medium 0.146 2475 pass no call 6664 PTEN_E00001156321_1 ENSG00000171862 6 of 8 3 FFPE CATTT C/T CTGTG CMDL140201 FLD0198 FLD0222 synonymous PTEN c.711G>A c.711G>A(p.%3D) aaG/aaA chr10 89717686 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717686", "IGV") low 0.142 5976 no call QD 255 PTEN_E00001156321_1 ENSG00000171862 7 of 9 rs773353820, COSM5806 21 FFPE GACAA G/A TTCAT CMDL140201 FLD0198 FLD0222 synonymous PTEN c.777C>T c.777C>T(p.%3D) caC/caT chr10 89717752 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717752", "IGV") low 0.134 4413 QD no call 33 PTEN_E00001156321_2 ENSG00000171862 7 of 9 24 FFPE TTCCA C/T AAACA CMDL140201 FLD0198 FLD0222 splice_donor PTEN c.801+1G>A chr10 89717777 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717777", "IGV") low 0.134 2148 no call QD 3524 PTEN_E00001156321_4m ENSG00000171862 7 of 8 CS002685, CS992481, CD011189, COSM5970 8 FFPE AAAAG G/A TTTGT CMDL140201 FLD0198 FLD0222 nonsynonymous PTEN c.536G>A p.S179N aGc/aAc chr10 89711918 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89711918", "IGV") medium 0.152 2275 pass no call 7566 PTEN_E00001156327_4 ENSG00000171862 6 of 9 COSM5249 tolerated(0.38) benign(0.002) 10 FFPE TTATA G/A CTACC CMDL140201 FLD0198 FLD0222 synonymous PTEN c.543G>A c.543G>A(p.%3D) ctG/ctA chr10 89711925 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89711925", "IGV") low 0.103 2723 no call QD 2569 PTEN_E00001156327_4 ENSG00000171862 6 of 9 COSM1561204 17 FFPE TACCT G/A TTAAA CMDL140201 FLD0198 FLD0222 nonsynonymous PTEN c.559G>A p.D187N Gat/Aat chr10 89711941 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89711941", "IGV") low 0.150 4539 QD no call 2351 PTEN_E00001156327_4 ENSG00000171862 6 of 9 COSM5849, COSM1577268 tolerated(0.49) benign(0.002) 33 FFPE ATCTG G/A ATTAT CMDL140201 FLD0198 FLD0222 splice_region,intron PTEN c.209+5G>A chr10 89685319 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89685319", "IGV") low 0.187 3782 QD no call 2343 PTEN_E00001156344_1 ENSG00000171862 3 of 8 CS982331, COSM5949, COSM5930, COSM5916 20 FFPE TGTAA G/A TATGT CMDL140201 FLD0198 FLD0222 intron TP53 c.993+144G>A chr17 7576709 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576709", "IGV") low 0.170 6051 no call QD 5925 TP53_00001404886_13 ENSG00000141510 9 of 10 6 FFPE AGCTA C/T AACCA CMDL140201 FLD0198 FLD0222 nonsynonymous TP53 c.607G>A p.V203M Gtg/Atg chr17 7578242 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578242", "IGV") low 0.090 2131 no call QD 318 TP53_E00001255919_1 ENSG00000141510 6 of 11 rs730882003, TP53_g.12676G>C, TP53_g.12676del, TP53_g.12676G>A, TP53_g.12676G>T, COSM44365, COSM45308, COSM43599 deleterious(0) benign(0.424) uncertain_significance 11 FFPE CTCCA C/T ACGCA CMDL140201 FLD0198 FLD0222 nonsynonymous TP53 c.452C>T p.P151L cCc/cTc chr17 7578478 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578478", "IGV") medium 0.266 3688 pass no call 11955 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12440C>A, TP53_g.12440C>T, TP53_g.12440C>G, COSM44003, COSM44288, COSM11476, COSM259150, COSM707868, COSM259149, COSM707869, COSM259151, COSM707871, COSM4139888, COSM3388218, COSM4139887, COSM2744918, COSM259152, COSM707870 deleterious(0.02) probably_damaging(0.998) 31 FFPE GCGGG G/A GTGTG CMDL140201 FLD0198 FLD0222 synonymous TP53 c.468C>T c.468C>T(p.%3D) cgC/cgT chr17 7578462 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578462", "IGV") low 0.158 3765 no call QD 2718 TP53_E00001255919_6 ENSG00000141510 5 of 11 rs761222871, TP53_g.12456C>G, TP53_g.12456del, TP53_g.12456C>T, TP53_g.12456C>A, COSM44301, COSM43710, COSM45783 likely_benign 18 FFPE CGGAC G/A CGGGT CMDL140201 FLD0198 FLD0222 intron TP53 c.74+53C>T chr17 7579786 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579786", "IGV") low 0.133 1113 QD no call 1977 TP53_E00001596491_1 ENSG00000141510 2 of 10 9 FFPE TAGGG G/A GCTGG CMDL140201 FLD0198 FLD0222 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.990 0.995 2218 2757 pass pass 63192 77542 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140201 FLD0198 FLD0222 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.995 0.994 3059 3800 pass pass 87923 106877 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140201 FLD0198 FLD0222 splice_region,intron TP53 c.782+3C>T chr17 7577496 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577496", "IGV") low 0.166 4990 no call QD 3747 TP53_E00001665758_1 ENSG00000141510 7 of 10 TP53_g.13422C>G, TP53_g.13422C>T, COSM45192 47 FFPE CTCCT G/A ACCTG CMDL140201 FLD0198 FLD0222 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") medium 0.350 3828 no call pass 21403 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL140201 FLD0198 FLD0222 nonsynonymous TP53 c.1154T>C p.F385S tTc/tCc chr17 7572955 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7572955", "IGV") low 0.218 2021 QD no call 3463 TP53_E00001757276_1 ENSG00000141510 11 of 11 tolerated(0.11) benign(0.103) 56 FFPE TCTTG A/G ACATG CMDL150036 FLD0199 FLD0223 intron EGFR c.2284-23G>A chr7 55248963 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55248963", "IGV") medium 0.314 2990 pass no call 13669 EGFR_E00001601336_1 ENSG00000146648 19 of 27 43 FFPE ACACT G/A ACGTG CMDL150036 FLD0199 FLD0223 nonsynonymous EGFR c.2317C>T p.H773Y Cac/Tac chr7 55249019 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249019", "IGV") low 0.090 2992 QD no call 2600 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs767075090 tolerated(0.54) benign(0.102) 74 FFPE ACCCC C/T ACGTG CMDL150036 FLD0199 FLD0223 synonymous EGFR c.2332C>T c.2332C>T(p.%3D) Ctg/Ttg chr7 55249034 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249034", "IGV") low 0.089 2992 QD no call 2600 EGFR_E00001601336_1 ENSG00000146648 20 of 28 59 FFPE GCCTG C/T TGGGC CMDL150036 FLD0199 FLD0223 synonymous EGFR c.2352C>T c.2352C>T(p.%3D) tcC/tcT chr7 55249054 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249054", "IGV") low 0.089 1473 QD no call 1179 EGFR_E00001601336_1 ENSG00000146648 20 of 28 39 FFPE ACCTC C/T ACCGT CMDL150036 FLD0199 FLD0223 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.672 0.320 1461 973 pass pass 37120 8927 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150036 FLD0199 FLD0223 synonymous EGFR c.2355C>T c.2355C>T(p.%3D) acC/acT chr7 55249057 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249057", "IGV") low 0.107 2544 no call QD 3223 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs148188503, COSM1451599 likely_benign 36 FFPE TCCAC C/T GTGCA CMDL150036 FLD0199 FLD0223 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.260 0.582 2519 2589 pass pass 17286 56090 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150036 FLD0199 FLD0223 intron EGFR c.2626-45G>A chr7 55260414 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260414", "IGV") medium 0.281 2803 no call pass 23819 EGFR_E00001631695_1 ENSG00000146648 21 of 27 rs773138582 27 FFPE CAGAG G/A GAAAC CMDL150036 FLD0199 FLD0223 splice_region,intron EGFR c.2626-5C>T chr7 55260454 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260454", "IGV") low 0.193 4892 QD no call 5431 EGFR_E00001631695_1 ENSG00000146648 21 of 27 rs563080257 T:0.0004 67 FFPE CCATC C/T CAAGG CMDL150036 FLD0199 FLD0223 synonymous EGFR c.2572C>T c.2572C>T(p.%3D) Ctg/Ttg chr7 55259514 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259514", "IGV") low 0.105 2940 no call QD 3213 EGFR_E00001681524_1 ENSG00000146648 21 of 28 rs121913443, COSM26129, COSM12366 uncertain_significance,likely_benign 12 FFPE TTGGG C/T TGGCC CMDL150036 FLD0199 FLD0223 intron EGFR c.3115-38C>T chr7 55269390 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269390", "IGV") medium 0.192 4806 pass no call 9646 EGFR_E00001773562_1 ENSG00000146648 25 of 27 36 FFPE TGGTA C/T AAGCA CMDL150036 FLD0199 FLD0223 intron EGFR c.3115-17C>T chr7 55269411 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269411", "IGV") medium 0.194 4806 pass no call 9703 EGFR_E00001773562_1 ENSG00000146648 25 of 27 rs776899446 57 FFPE AACTT C/T TCTGT CMDL150036 FLD0199 FLD0223 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.997 0.998 2124 2430 pass pass 90788 105564 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150036 FLD0199 FLD0223 nonsynonymous EGFR c.2746G>A p.D916N Gac/Aac chr7 55266454 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266454", "IGV") low 0.186 4841 no call QD 4385 EGFR_E00001779947_1 ENSG00000146648 23 of 28 rs376822837 deleterious(0) probably_damaging(0.973) 71 FFPE CATAT G/A ACGGA CMDL150036 FLD0199 FLD0223 nonsynonymous EGFR c.2800C>T p.P934S Cct/Tct chr7 55266508 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266508", "IGV") low 0.180 4841 no call QD 3324 EGFR_E00001779947_1 ENSG00000146648 23 of 28 rs575565383, COSM3923814 deleterious(0.03) probably_damaging(1) T:0.0004 44 FFPE GCCTC C/T CTCAG CMDL150036 FLD0199 FLD0223 nonsynonymous EGFR c.3022G>A p.D1008N Gac/Aac chr7 55268956 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268956", "IGV") medium 0.162 3107 pass no call 9220 EGFR_E00001801208_1 ENSG00000146648 25 of 28 tolerated(0.12) benign(0.002) 12 FFPE ACATG G/A ACGAC CMDL150036 FLD0199 FLD0223 intron PIK3CA c.1540-26A>G chr3 178935972 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178935972", "IGV") medium 0.732 302 pass no call 8603 PIK3CA_Ex10_gap ENSG00000121879 9 of 20 8 FFPE AAGCT A/G TATAA CMDL150036 FLD0199 FLD0223 nonsynonymous PIK3CA c.1618C>T p.L540F Ctc/Ttc chr3 178936076 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178936076", "IGV") medium 0.734 607 pass no call 11330 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM219115 deleterious(0.01) probably_damaging(0.998) 51 FFPE ATCCT C/T TCTCT CMDL150036 FLD0199 FLD0223 nonsynonymous PIK3CA c.3148G>A p.G1050S Ggc/Agc chr3 178952093 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178952093", "IGV") low 0.184 5735 no call QD 9106 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 COSM249882, COSM1421015 tolerated(0.93) benign(0.032) 36 FFPE ATGGT G/A GCTGG CMDL150036 FLD0199 FLD0223 synonymous PIK3CA c.3174C>T c.3174C>T(p.%3D) atC/atT chr3 178952119 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178952119", "IGV") low 0.149 5735 no call QD 364 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 62 FFPE TGGAT C/T TTCCA CMDL150036 FLD0199 FLD0223 nonsynonymous PTEN c.970G>A p.D324N Gat/Aat chr10 89720819 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720819", "IGV") medium 0.566 4782 no call pass 54514 PTEN_E00001156315_7 ENSG00000171862 8 of 9 tolerated(0.13) benign(0.056) 77 FFPE AAAAT G/A ATCTT CMDL150036 FLD0199 FLD0223 synonymous PTEN c.702G>A c.702G>A(p.%3D) cgG/cgA chr10 89717677 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717677", "IGV") low 0.200 4617 QD no call 6851 PTEN_E00001156321_2 ENSG00000171862 7 of 9 38 FFPE CGACG G/A GAAGA CMDL150036 FLD0199 FLD0223 intron PTEN c.801+55C>T chr10 89717831 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717831", "IGV") medium 0.418 3527 no call pass 25505 PTEN_E00001156321_4m ENSG00000171862 7 of 8 62 FFPE AAAAG C/T TATAT CMDL150036 FLD0199 FLD0223 synonymous PTEN c.541C>T c.541C>T(p.%3D) Ctg/Ttg chr10 89711923 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711923", "IGV") medium 0.207 2527 no call pass 12641 PTEN_E00001156327_4 ENSG00000171862 6 of 9 15 FFPE GCTAC C/T TGTTA CMDL150036 FLD0199 FLD0223 synonymous PTEN c.624C>T c.624C>T(p.%3D) ggC/ggT chr10 89712006 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89712006", "IGV") low 0.172 5046 no call QD 3406 PTEN_E00001156327_4 ENSG00000171862 6 of 9 rs370162160, COSM1492348 44 FFPE AGTGG C/T GGAAC CMDL150036 FLD0199 FLD0223 nonsynonymous PTEN c.376G>A p.A126T Gct/Act chr10 89692892 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692892", "IGV") medium 0.214 2458 no call pass 13338 PTEN_E00001156330_1 ENSG00000171862 5 of 9 CM110132, COSM5211, COSM28889, COSM5051 deleterious(0) probably_damaging(0.995) 7 FFPE GTAAA G/A CTGGA CMDL150036 FLD0199 FLD0223 nonsynonymous PTEN c.352C>T p.H118Y Cat/Tat chr10 89692868 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692868", "IGV") low 0.096 732 QD no call 620 PTEN_E00001156330_3 ENSG00000171862 5 of 9 deleterious(0) benign(0.309) 5 FFPE ACAAT C/T ATGTT CMDL150036 FLD0199 FLD0223 nonsynonymous PTEN c.466G>A p.G156R Ggg/Agg chr10 89692982 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692982", "IGV") medium 0.310 1753 no call pass 7473 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5103 deleterious(0.04) benign(0.236) 43 FFPE TCTAT G/A GGGAA CMDL150036 FLD0199 FLD0223 nonsynonymous PTEN c.1093G>A p.V365I Gta/Ata chr10 89725110 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725110", "IGV") medium 0.306 5388 no call pass 22528 PTEN_E00001456541_1 ENSG00000171862 9 of 9 rs758542021, COSM5056 tolerated(0.24) benign(0.05) 51 FFPE CTTCT G/A TAACA CMDL150036 FLD0199 FLD0223 nonsynonymous PTEN c.1111G>A p.D371N Gac/Aac chr10 89725128 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725128", "IGV") low 0.142 5388 no call QD 304 PTEN_E00001456541_1 ENSG00000171862 9 of 9 tolerated(0.19) probably_damaging(0.998) 33 FFPE TTAGT G/A ACAAT CMDL150036 FLD0199 FLD0223 stop_gained PTEN c.1186C>T p.Q396* Cag/Tag chr10 89725203 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725203", "IGV") low 0.154 6169 QD no call 2360 PTEN_E00001456541_2 ENSG00000171862 9 of 9 38 FFPE AAGAT C/T AGCAT CMDL150036 FLD0199 FLD0223 intron TP53 c.672+41G>A chr17 7578136 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578136", "IGV") low 0.128 4033 no call QD 584 TP53_E00001255919_1 ENSG00000141510 6 of 10 rs752280122 27 FFPE ACCAC C/T CTTAA CMDL150036 FLD0199 FLD0223 intron TP53 c.559+40C>T chr17 7578331 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578331", "IGV") low 0.196 5357 no call QD 8305 TP53_E00001255919_3 ENSG00000141510 5 of 10 59 FFPE CCCTG G/A GCAAC CMDL150036 FLD0199 FLD0223 synonymous TP53 c.468C>T c.468C>T(p.%3D) cgC/cgT chr17 7578462 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578462", "IGV") low 0.146 4439 QD no call 1811 TP53_E00001255919_6 ENSG00000141510 5 of 11 rs761222871, TP53_g.12456C>G, TP53_g.12456del, TP53_g.12456C>T, TP53_g.12456C>A, COSM44301, COSM43710, COSM45783 likely_benign 18 FFPE CGGAC G/A CGGGT CMDL150036 FLD0199 FLD0223 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.341 0.809 1817 2207 pass pass 10163 42563 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150036 FLD0199 FLD0223 start_lost TP53 c.3G>A p.M1? atG/atA chr17 7579910 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579910", "IGV") medium 0.147 1125 no call pass 2887 TP53_E00001596491_1 ENSG00000141510 2 of 11 deleterious_low_confidence(0.01) probably_damaging(0.985) 13 FFPE TCCTC C/T ATGGC CMDL150036 FLD0199 FLD0223 intron TP53 c.375+21G>A chr17 7579291 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579291", "IGV") low 0.171 4456 no call QD 6627 TP53_E00001612188_1 ENSG00000141510 4 of 10 rs761980616 12 FFPE GAAGC C/T AGCCC CMDL150036 FLD0199 FLD0223 synonymous TP53 c.366G>A c.366G>A(p.%3D) gtG/gtA chr17 7579321 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579321", "IGV") low 0.170 4456 no call QD 7181 TP53_E00001612188_1 ENSG00000141510 4 of 11 CD068497, TP53_g.11597del, TP53_g.11597G>C, TP53_g.11597G>A 42 FFPE CAAGT C/T ACAGA CMDL150036 FLD0199 FLD0223 nonsynonymous TP53 c.347C>T p.S116F tCt/tTt chr17 7579340 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579340", "IGV") low 0.146 4456 no call QD 4468 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11578C>G, TP53_g.11578C>T, COSM44044, COSM43715 deleterious(0.02) probably_damaging(1) 61 FFPE TCCCA G/A AATGC CMDL150036 FLD0199 FLD0223 stop_gained TP53 c.310C>T p.Q104* Cag/Tag chr17 7579377 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579377", "IGV") low 0.146 4456 no call QD 3980 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11541C>T, TP53_g.11541del, COSM10886, COSM308172, COSM308171, COSM3727867, COSM2745029 29 FFPE GCCCT G/A GTAGG CMDL150036 FLD0199 FLD0223 nonsynonymous TP53 c.254C>T p.P85L cCt/cTt chr17 7579433 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579433", "IGV") low 0.143 2700 no call QD 257 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11485C>T, COSM1386905, COSM45837, COSM1386906, COSM1386907 tolerated(0.42) benign(0.011) 56 FFPE GTGCA G/A GGGCC CMDL150036 FLD0199 FLD0223 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.789 0.459 2558 2700 pass pass 47642 24450 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150036 FLD0199 FLD0223 intron TP53 c.782+36C>T chr17 7577463 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577463", "IGV") low 0.077 2431 QD no call 654 TP53_E00001665758_1 ENSG00000141510 7 of 10 14 FFPE GCACA G/A CAGGC CMDL150036 FLD0199 FLD0223 intron TP53 c.782+32C>T chr17 7577467 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577467", "IGV") low 0.080 2431 QD no call 834 TP53_E00001665758_1 ENSG00000141510 7 of 10 rs368188803 A:0.0002 18 FFPE AGCAG G/A CCAGT CMDL150036 FLD0199 FLD0223 synonymous TP53 c.741C>T c.741C>T(p.%3D) aaC/aaT chr17 7577540 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577540", "IGV") medium 0.286 4876 pass no call 20215 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13378C>A, TP53_g.13378C>G, TP53_g.13378C>T, COSM44428, COSM45632 72 FFPE CTCCG G/A TTCAT CMDL150036 FLD0199 FLD0223 nonsynonymous TP53 c.713G>A p.C238Y tGt/tAt chr17 7577568 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577568", "IGV") low 0.167 5139 no call QD 2984 TP53_E00001665758_1 ENSG00000141510 7 of 11 rs730882005, CM034930, TP53_g.13350G>A, TP53_g.13350G>T, TP53_g.13350G>C, COSM43778, COSM44653, COSM11059, COSM179812, COSM99626, COSM249080, COSM99624, COSM179811, COSM249079, COSM3388191, COSM3403263, COSM2744631, COSM1649400, COSM99625, COSM179813, COSM249081 deleterious(0) probably_damaging(1) likely_pathogenic 44 FFPE TGTTA C/T ACATG CMDL150036 FLD0199 FLD0223 intron TP53 c.1100+43C>T chr17 7573884 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573884", "IGV") medium 0.170 2100 no call pass 8257 TP53_E00001728015_1 ENSG00000141510 10 of 10 4 FFPE CCTAG G/A AAGGC CMDL150036 FLD0199 FLD0223 synonymous TP53 c.1050C>T c.1050C>T(p.%3D) ctC/ctT chr17 7573977 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573977", "IGV") medium 0.244 3518 pass no call 10062 TP53_E00001728015_1 ENSG00000141510 10 of 11 TP53_g.16941del, COSM307337, COSM45375 60 FFPE TCCTT G/A AGTTC CMDL150036 FLD0199 FLD0223 intron TP53 c.993+28G>A chr17 7576825 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576825", "IGV") low 0.082 3003 QD no call 297 TP53_E00001789298_1 ENSG00000141510 9 of 10 19 FFPE TTCCA C/T TTGAT CMDL150036 FLD0199 FLD0223 nonsynonymous TP53 c.904G>A p.G302R Ggg/Agg chr17 7577034 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577034", "IGV") low 0.091 2018 QD no call 1035 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13884G>A, TP53_g.13884del, COSM44237, COSM1386586, COSM1386587 tolerated(0.12) benign(0.033) 12 FFPE GCTCC C/T TGGGG CMDL150036 FLD0199 FLD0223 nonsynonymous TP53 c.838A>G p.R280G Aga/Gga chr17 7577100 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7577100", "IGV") high 0.459 0.276 3976 4493 pass pass 38714 15784 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs753660142, TP53_g.13818A>G, TP53_g.13818A>T, TP53_g.13818del, TP53_g.13818A>C, COSM11123, COSM46183, COSM44390, COSM562339, COSM1480058, COSM3378442, COSM3958800, COSM3958799, COSM1649339 deleterious(0) probably_damaging(0.947) 67 FFPE GTCTC T/C CCCAG CMDL150059 FLD0200 FLD0224 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") medium 0.486 1304 no call pass 22456 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150059 FLD0200 FLD0224 nonsynonymous EGFR c.2404G>A p.V802I Gtc/Atc chr7 55249106 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249106", "IGV") medium 0.482 2513 no call pass 36076 EGFR_E00001601336_2 ENSG00000146648 20 of 28 COSM28516, COSM1651734 tolerated(0.06) benign(0.017) 85 FFPE ACTAT G/A TCCGG CMDL150059 FLD0200 FLD0224 synonymous EGFR c.2406C>T c.2406C>T(p.%3D) gtC/gtT chr7 55249108 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249108", "IGV") medium 0.502 2513 no call pass 26093 EGFR_E00001601336_2 ENSG00000146648 20 of 28 87 FFPE TATGT C/T CGGGA CMDL150059 FLD0200 FLD0224 nonsynonymous EGFR c.2410G>A p.E804K Gaa/Aaa chr7 55249112 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249112", "IGV") medium 0.483 2513 no call pass 46597 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs552733360, COSM249780 tolerated(0.07) possibly_damaging(0.906) A:0.0002 83 FFPE TCCGG G/A AACAC CMDL150059 FLD0200 FLD0224 intron EGFR c.2626-44G>A chr7 55260415 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260415", "IGV") medium 0.998 1467 no call pass 62002 EGFR_E00001631695_1 ENSG00000146648 21 of 27 28 FFPE AGAGG G/A AAACT CMDL150059 FLD0200 FLD0224 synonymous EGFR c.2478C>T c.2478C>T(p.%3D) aaC/aaT chr7 55259420 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259420", "IGV") medium 0.267 5544 pass no call 17856 EGFR_E00001681524_1 ENSG00000146648 21 of 28 49 FFPE ATGAA C/T TACTT CMDL150059 FLD0200 FLD0224 synonymous EGFR c.2496C>T c.2496C>T(p.%3D) cgC/cgT chr7 55259438 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259438", "IGV") medium 0.445 4955 no call pass 41563 EGFR_E00001681524_1 ENSG00000146648 21 of 28 67 FFPE CGTCG C/T TTGGT CMDL150059 FLD0200 FLD0224 nonsynonymous EGFR c.2575G>A p.A859T Gcc/Acc chr7 55259517 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259517", "IGV") medium 0.484 2764 no call pass 28764 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM12675 deleterious(0) probably_damaging(0.999) 55 FFPE GGCTG G/A CCAAA CMDL150059 FLD0200 FLD0224 synonymous EGFR c.2583G>A c.2583G>A(p.%3D) ctG/ctA chr7 55259525 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259525", "IGV") medium 0.353 2764 no call pass 17196 EGFR_E00001681524_2 ENSG00000146648 21 of 28 47 FFPE AAACT G/A CTGGG CMDL150059 FLD0200 FLD0224 nonsynonymous EGFR c.2590G>A p.A864T Gcg/Acg chr7 55259532 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259532", "IGV") medium 0.481 2764 no call pass 28533 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM13197 tolerated(0.27) probably_damaging(0.911) 40 FFPE TGGGT G/A CGGAA CMDL150059 FLD0200 FLD0224 splice_acceptor EGFR c.2702-2A>G chr7 55266408 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55266408", "IGV") low 0.111 145 no call QD 241 EGFR_E00001779947_1 ENSG00000146648 22 of 27 25 FFPE CTCTC A/G GGGGT CMDL150059 FLD0200 FLD0224 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") medium 1.000 0.987 1 145 LowQual pass 17 6089 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150059 FLD0200 FLD0224 synonymous EGFR c.2779C>T c.2779C>T(p.%3D) Ctg/Ttg chr7 55266487 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266487", "IGV") medium 0.586 292 no call pass 3513 EGFR_E00001779947_1 ENSG00000146648 23 of 28 rs374672672 65 FFPE CCATC C/T TGGAG CMDL150059 FLD0200 FLD0224 splice_region,intron EGFR c.2848+3G>A chr7 55266559 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266559", "IGV") medium 0.222 3696 pass no call 7691 EGFR_E00001779947_2 ENSG00000146648 23 of 27 65 FFPE AGTGT G/A AGTGA CMDL150059 FLD0200 FLD0224 intron EGFR c.2849-14C>T chr7 55267995 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55267995", "IGV") low 0.857 14 no call pass 227 EGFR_E00001790701_1 ENSG00000146648 23 of 27 37 FFPE TTTCT C/T ATTCC CMDL150059 FLD0200 FLD0224 nonsynonymous EGFR c.3016G>A p.D1006N Gac/Aac chr7 55268950 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268950", "IGV") medium 0.323 3053 pass no call 25428 EGFR_E00001801208_2 ENSG00000146648 25 of 28 tolerated(0.12) benign(0.284) 12 FFPE AAGAA G/A ACATG CMDL150059 FLD0200 FLD0224 intron EGFR c.3114+23T>C chr7 55269071 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55269071", "IGV") medium 0.196 1658 no call pass 3637 EGFR_E00001801208_2 ENSG00000146648 25 of 27 8 FFPE CTCTC T/C CTCTC CMDL150059 FLD0200 FLD0224 nonsynonymous EGFR c.2255C>T p.S752F tCt/tTt chr7 55242485 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55242485", "IGV") medium 0.455 2772 pass no call 23351 EGFR_Exon19 ENSG00000146648 19 of 28 rs121913464, COSM13186, COSM4170219 deleterious(0) probably_damaging(1) 33 FFPE AACAT C/T TCCGA CMDL150059 FLD0200 FLD0224 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") low 0.429 35 no call pass 240 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL150059 FLD0200 FLD0224 splice_region,synonymous TP53 c.94C>T c.94C>T(p.%3D) Ctg/Ttg chr17 7579702 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579702", "IGV") low 0.550 35 no call pass 347 EXP0116_TP53_E3 ENSG00000141510 3 of 11 33 FFPE TACCA G/A AACGT CMDL150059 FLD0200 FLD0224 nonsynonymous KRAS c.100C>T p.P34S Cca/Tca chr12 25398219 G A =hyperlink("http://localhost:60151/goto?locus=chr12:25398219", "IGV") medium 0.920 3159 pass no call 79008 KRAS_AA_HS ENSG00000133703 2 of 6 COSM27637 deleterious(0.02) possibly_damaging(0.855) 36 FFPE TGTTG G/A ATCAT CMDL150059 FLD0200 FLD0224 nonsynonymous KRAS c.35G>A p.G12D gGt/gAt chr12 25398284 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") high 0.997 0.995 3159 4242 pass pass 90303 115511 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) benign(0.361) 26 FFPE CGCCA C/T CAGCT CMDL150059 FLD0200 FLD0224 synonymous PIK3CA c.1629C>T c.1629C>T(p.%3D) atC/atT chr3 178936087 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178936087", "IGV") medium 0.229 209 no call pass 559 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 rs772724438 40 FFPE GAAAT C/T ACTGA CMDL150059 FLD0200 FLD0224 stop_retained PIK3CA c.3206G>A c.3206G>A(p.%3D) tGa/tAa chr3 178952151 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178952151", "IGV") medium 0.428 4312 pass no call 31512 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 57 FFPE GAACT G/A AAAAG CMDL150059 FLD0200 FLD0224 3_prime_UTR PIK3CA c.*41A>G chr3 178952193 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178952193", "IGV") medium 0.306 2498 no call pass 22750 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 15 FFPE TCCAC A/G CTGCA CMDL150059 FLD0200 FLD0224 intron PTEN c.802-118T>C chr10 89720533 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720533", "IGV") low 0.466 95 pass no call 1631 PTEN_E00001156315_1m ENSG00000171862 7 of 8 53 FFPE TATTT T/C GTTGA CMDL150059 FLD0200 FLD0224 splice_region,intron PTEN c.635-8C>T chr10 89717602 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717602", "IGV") low 0.161 4864 no call QD 2390 PTEN_E00001156321_1 ENSG00000171862 6 of 8 rs780495238 32 FFPE TTTAA C/T CATGC CMDL150059 FLD0200 FLD0224 nonsynonymous PTEN c.701G>A p.R234Q cGg/cAg chr10 89717676 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717676", "IGV") medium 0.288 4864 no call pass 16538 PTEN_E00001156321_1 ENSG00000171862 7 of 9 CM023439, rs121909235, COSM540238, COSM23654 tolerated(0.16) benign(0.022) pathogenic,risk_factor 31 FFPE ACGAC G/A GGAAG CMDL150059 FLD0200 FLD0224 synonymous PTEN c.618C>T c.618C>T(p.%3D) ttC/ttT chr10 89712000 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89712000", "IGV") medium 0.380 3126 no call pass 19301 PTEN_E00001156327_4 ENSG00000171862 6 of 9 50 FFPE ATGTT C/T AGTGG CMDL150059 FLD0200 FLD0224 intron PTEN c.253+63C>T chr10 89690909 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89690909", "IGV") medium 0.424 4780 pass no call 35433 PTEN_E00001156337_4 ENSG00000171862 4 of 8 3 FFPE ACTGT C/T ATAAC CMDL150059 FLD0200 FLD0224 nonsynonymous PTEN c.176C>T p.S59L tCa/tTa chr10 89685281 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89685281", "IGV") medium 0.409 2429 pass no call 17166 PTEN_E00001156344_1 ENSG00000171862 3 of 9 CM043772, CM110148, COSM87316, COSM685105, COSM5313 tolerated(0.1) benign(0.106) 58 FFPE GGATT C/T AAAGC CMDL150059 FLD0200 FLD0224 synonymous PTEN c.198G>A c.198G>A(p.%3D) aaG/aaA chr10 89685303 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89685303", "IGV") low 0.200 2177 no call QD 3027 PTEN_E00001156344_1 ENSG00000171862 3 of 9 COSM4016453, COSM5191 36 FFPE TACAA G/A ATATA CMDL150059 FLD0200 FLD0224 nonsynonymous PTEN c.1105G>A p.V369I Gtt/Att chr10 89725122 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725122", "IGV") medium 0.378 3323 no call pass 21133 PTEN_E00001456541_1 ENSG00000171862 9 of 9 rs587782224 tolerated(0.4) benign(0.007) uncertain_significance 39 FFPE CAGAT G/A TTAGT CMDL150059 FLD0200 FLD0224 nonsynonymous PTEN c.44G>A p.R15K aGa/aAa chr10 89624270 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624270", "IGV") low 0.198 3621 no call QD 5288 PTEN_E00001456562_1 ENSG00000171862 1 of 9 rs398123324, COSM5232, COSM5064 deleterious(0) benign(0.102) uncertain_significance 76 FFPE AAGGA G/A ATATC CMDL150059 FLD0200 FLD0224 nonsynonymous TP53 c.451C>G p.P151A Ccc/Gcc chr17 7578479 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7578479", "IGV") low 0.818 21 pass no call 354 TP53_E00001255919_5 25105660 ENSG00000141510 5 of 11 CM012662, rs28934874, CM941326, TP53_g.12439C>T, TP53_g.12439del, TP53_g.12439C>A, TP53_g.12439C>G, COSM44944, COSM10905, COSM43911, COSM43969, COSM121046, COSM984959, COSM99682, COSM984961, COSM99679, COSM121047, COSM984963, COSM99680, COSM121049, COSM3717669, COSM4070056, COSM3378358, COSM3717668, COSM1640859, COSM4070055, COSM121048, COSM984962, COSM99681 deleterious(0.01) possibly_damaging(0.902) likely_pathogenic,pathogenic 30 FFPE CGGGG G/C TGTGG CMDL150059 FLD0200 FLD0224 nonsynonymous TP53 c.452C>T p.P151L cCc/cTc chr17 7578478 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578478", "IGV") medium 0.983 2202 pass no call 58955 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12440C>A, TP53_g.12440C>T, TP53_g.12440C>G, COSM44003, COSM44288, COSM11476, COSM259150, COSM707868, COSM259149, COSM707869, COSM259151, COSM707871, COSM4139888, COSM3388218, COSM4139887, COSM2744918, COSM259152, COSM707870 deleterious(0.02) probably_damaging(0.998) 34 FFPE GCGGG G/A GTGTG CMDL150059 FLD0200 FLD0224 nonsynonymous TP53 c.266C>T p.P89L cCc/cTc chr17 7579421 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579421", "IGV") low 0.850 39 pass no call 736 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs730881994, TP53_g.11497C>T, COSM44677 tolerated(0.1) benign(0.007) uncertain_significance 44 FFPE AGGAG G/A GGGCT CMDL150059 FLD0200 FLD0224 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") low 0.950 39 pass no call 927 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150059 FLD0200 FLD0224 nonsynonymous TP53 c.703A>G p.N235D Aac/Gac chr17 7577578 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7577578", "IGV") low 1.000 2 LowQual no call 22 TP53_E00001665758_1 ENSG00000141510 7 of 11 CM941331, TP53_g.13340A>T, TP53_g.13340A>G, TP53_g.13340del, TP53_g.13340A>C, COSM11542, COSM45172, COSM45623, COSM45975, COSM1559476, COSM1559477, COSM1559478 deleterious(0.01) probably_damaging(0.927) 34 FFPE GTAGT T/C GTAGT CMDL150059 FLD0200 FLD0224 nonsynonymous TP53 c.1015G>A p.E339K Gag/Aag chr17 7574012 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7574012", "IGV") medium 0.675 1337 pass no call 33960 TP53_E00001728015_1 25105660 ENSG00000141510 10 of 11 CM984588, rs17882252, TP53_g.16906G>C, TP53_g.16906G>T, TP53_g.16906G>A, COSM11286, COSM46250, COSM46153, COSM214290 tolerated(0.2) benign(0.055) uncertain_significance 25 FFPE CATCT C/T GAAGC CMDL150059 FLD0200 FLD0224 nonsynonymous TP53 c.856G>A p.E286K Gaa/Aaa chr17 7577082 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577082", "IGV") low 1.000 2 no call LowQual 22 TP53_E00001789298_3 ENSG00000141510 8 of 11 CM076567, TP53_g.13836G>C, TP53_g.13836del, TP53_g.13836G>T, TP53_g.13836G>A, COSM44250, COSM10726, COSM43919, COSM45277, COSM99924, COSM1480057, COSM318163, COSM3522693, COSM1645467, COSM1649346 deleterious(0) probably_damaging(0.982) 60 FFPE CTCTT C/T CTCTG CMDL150059 FLD0200 FLD0224 synonymous TP53 c.795G>A c.795G>A(p.%3D) ctG/ctA chr17 7577143 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577143", "IGV") medium 0.994 780 pass no call 21280 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13775G>C, TP53_g.13775G>A, TP53_g.13775G>T, COSM43785, COSM45285, COSM1386600, COSM3970344, COSM3970343 24 FFPE CGTCC C/T AGTAG CMDL150072 FLD0201 FLD0225 intron EGFR c.2284-61A>G chr7 55248925 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55248925", "IGV") low 0.005 0.002 1100 1366 QD QD 211 57 EGFR_E00001601336_1 ENSG00000146648 19 of 27 5 FFPE GGTCC A/G TGTGC CMDL150072 FLD0201 FLD0225 intron EGFR c.2284-60T>C chr7 55248926 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55248926", "IGV") low 0.998 0.999 1100 1366 QD QD 211 57 EGFR_E00001601336_1 18199332, 21869887 ENSG00000146648 19 of 27 rs10241451 C:0.1743 6 FFPE GTCCA T/C GTGCC CMDL150072 FLD0201 FLD0225 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.988 0.985 1275 1852 pass pass 53559 77924 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150072 FLD0201 FLD0225 nonsynonymous EGFR c.2362C>T p.L788F Ctc/Ttc chr7 55249064 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249064", "IGV") medium 0.149 1852 no call pass 4340 EGFR_E00001601336_1 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(1) 29 FFPE TGCAG C/T TCATC CMDL150072 FLD0201 FLD0225 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.997 0.993 1866 2770 pass pass 83648 123977 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150072 FLD0201 FLD0225 nonsynonymous EGFR c.2708C>T p.T903I aCt/aTt chr7 55266416 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266416", "IGV") low 0.085 1869 LowQual,QD no call 16 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(1) 33 FFPE GGTGA C/T TGTTT CMDL150072 FLD0201 FLD0225 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.998 0.997 1869 2884 pass pass 80165 122443 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150072 FLD0201 FLD0225 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") high 0.506 0.386 1151 1671 pass pass 12507 10694 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL150072 FLD0201 FLD0225 nonsynonymous KRAS c.35G>T p.G12V gGt/gTt chr12 25398284 C A =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") low 0.163 6584 no call QD 3094 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) possibly_damaging(0.479) 26 FFPE CGCCA C/A CAGCT CMDL150072 FLD0201 FLD0225 nonsynonymous PIK3CA c.3140A>T p.H1047L cAt/cTt chr3 178952085 A T =hyperlink("http://localhost:60151/goto?locus=chr3:178952085", "IGV") low 0.184 0.166 3690 5979 QD QD 4676 3464 PIK3CA_Exn21_gap 25710561 ENSG00000121879 21 of 21 rs121913279, COSM776, COSM775, COSM249874, COSM94987, COSM94986 tolerated(0.44) benign(0.085) pathogenic 28 FFPE TGCAC A/T TCATG CMDL150072 FLD0201 FLD0225 nonsynonymous PTEN c.362C>T p.A121V gCa/gTa chr10 89692878 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692878", "IGV") low 0.086 1605 QD no call 362 PTEN_E00001156330_3 ENSG00000171862 5 of 9 rs121909237, COSM5273 tolerated(0.42) possibly_damaging(0.669) pathogenic 15 FFPE TGCAG C/T AATTC CMDL150072 FLD0201 FLD0225 nonsynonymous PTEN c.467G>A p.G156E gGg/gAg chr10 89692983 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692983", "IGV") low 0.101 3151 QD no call 3553 PTEN_E00001156330_3 ENSG00000171862 5 of 9 deleterious(0) possibly_damaging(0.853) 42 FFPE CTATG G/A GGAAG CMDL150072 FLD0201 FLD0225 nonsynonymous PTEN c.469G>A p.E157K Gaa/Aaa chr10 89692985 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692985", "IGV") low 0.107 3151 QD no call 4069 PTEN_E00001156330_3 ENSG00000171862 5 of 9 rs121909220, CM971274, COSM921104, COSM1577254 tolerated(0.21) benign(0.115) pathogenic 40 FFPE ATGGG G/A AAGTA CMDL150072 FLD0201 FLD0225 intron PTEN c.164+11T>A chr10 89653877 T A =hyperlink("http://localhost:60151/goto?locus=chr10:89653877", "IGV") medium 0.232 2980 pass no call 6139 PTEN_E00001156351_1 ENSG00000171862 2 of 8 rs774040639 20 FFPE AATGC T/A TTGAT CMDL150072 FLD0201 FLD0225 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.168 3022 QD no call 2592 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150072 FLD0201 FLD0225 nonsynonymous TP53 c.986C>T p.T329I aCc/aTc chr17 7576860 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576860", "IGV") low 0.119 5114 QD no call 3794 TP53_E00001789298_1 ENSG00000141510 9 of 11 TP53_g.14058C>T, TP53_g.14058C>G, COSM46146 tolerated(0.09) benign(0.309) 54 FFPE GAAGG G/A TGAAA CMDL150075 FLD0202 FLD0226 nonsynonymous BRAF c.1768G>A p.V590I Gta/Ata chr7 140453167 C T =hyperlink("http://localhost:60151/goto?locus=chr7:140453167", "IGV") low 0.197 3928 QD no call 6518 BRAF_AA_HS ENSG00000157764 15 of 18 COSM51383 deleterious(0) benign(0.414) 41 FFPE TTTTA C/T TGTGA CMDL150075 FLD0202 FLD0226 intron EGFR c.2284-61A>G chr7 55248925 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55248925", "IGV") low 0.004 694 QD no call 114 EGFR_E00001601336_1 ENSG00000146648 19 of 27 5 FFPE GGTCC A/G TGTGC CMDL150075 FLD0202 FLD0226 intron EGFR c.2284-60T>C chr7 55248926 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55248926", "IGV") low 0.995 1.000 694 22 QD pass 114 908 EGFR_E00001601336_1 18199332, 21869887 ENSG00000146648 19 of 27 rs10241451 C:0.1743 6 FFPE GTCCA T/C GTGCC CMDL150075 FLD0202 FLD0226 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") medium 0.987 1.000 757 22 pass pass 31301 900 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.2386G>A p.G796S Ggc/Agc chr7 55249088 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249088", "IGV") low 0.955 22 no call pass 807 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs754426793, CM085969, COSM20891 deleterious(0) probably_damaging(1) 5 FFPE CCTTC G/A GCTGC CMDL150075 FLD0202 FLD0226 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.996 0.995 1486 1768 pass pass 66078 79557 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150075 FLD0202 FLD0226 synonymous EGFR c.2409G>A c.2409G>A(p.%3D) cgG/cgA chr7 55249111 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249111", "IGV") medium 0.622 3351 no call pass 44263 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs397517123 likely_benign 84 FFPE GTCCG G/A GAACA CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.2455G>A p.V819M Gtg/Atg chr7 55249157 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249157", "IGV") medium 0.622 1632 no call pass 37869 EGFR_E00001601336_2 ENSG00000146648 20 of 28 deleterious(0.02) probably_damaging(0.999) 38 FFPE GGTGT G/A TGCAG CMDL150075 FLD0202 FLD0226 splice_region,synonymous EGFR c.2469G>A c.2469G>A(p.%3D) aaG/aaA chr7 55249171 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249171", "IGV") medium 0.994 1381 pass no call 57788 EGFR_E00001601336_2 ENSG00000146648 20 of 28 24 FFPE GCAAA G/A GTAAT CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.2630C>T p.P877L cCt/cTt chr7 55260463 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260463", "IGV") medium 0.206 3073 pass no call 17744 EGFR_E00001631695_1 ENSG00000146648 22 of 28 deleterious(0) probably_damaging(1) 76 FFPE GGTGC C/T TATCA CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.2654C>T p.S885L tCa/tTa chr7 55260487 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260487", "IGV") medium 0.207 3073 pass no call 17744 EGFR_E00001631695_1 ENSG00000146648 22 of 28 rs397517137 deleterious(0.01) probably_damaging(1) uncertain_significance 66 FFPE GGAAT C/T AATTT CMDL150075 FLD0202 FLD0226 stop_gained EGFR c.2694G>A p.W898* tgG/tgA chr7 55260527 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260527", "IGV") medium 0.784 1521 pass no call 46167 EGFR_E00001631695_1 ENSG00000146648 22 of 28 26 FFPE GTCTG G/A AGCTA CMDL150075 FLD0202 FLD0226 intron EGFR c.2470-31G>A chr7 55259381 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259381", "IGV") low 0.137 2374 no call QD 2623 EGFR_E00001681524_1 ENSG00000146648 20 of 27 10 FFPE GATCT G/A TCCCT CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.2475G>A p.M825I atG/atA chr7 55259417 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259417", "IGV") low 0.169 4721 no call QD 4555 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM1578128 deleterious(0) probably_damaging(0.975) 46 FFPE GGCAT G/A AACTA CMDL150075 FLD0202 FLD0226 synonymous EGFR c.2484G>A c.2484G>A(p.%3D) ttG/ttA chr7 55259426 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259426", "IGV") medium 0.327 4367 pass no call 20103 EGFR_E00001681524_1 ENSG00000146648 21 of 28 rs727504312, COSM3639750 likely_benign 55 FFPE TACTT G/A GAGGA CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.2491C>T p.R831C Cgt/Tgt chr7 55259433 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259433", "IGV") low 0.168 4721 no call QD 3992 EGFR_E00001681524_1 ENSG00000146648 21 of 28 rs371228501, COSM24846 deleterious(0.01) probably_damaging(0.997) uncertain_significance T:0.0002 62 FFPE AGGAC C/T GTCGC CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.2563G>A p.D855N Gat/Aat chr7 55259505 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259505", "IGV") medium 0.189 2350 no call pass 10386 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM29577 deleterious(0) probably_damaging(0.988) 21 FFPE TCACA G/A ATTTT CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.2522G>A p.R841K aGg/aAg chr7 55259464 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259464", "IGV") medium 0.306 3107 pass no call 13272 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM20893 deleterious(0.04) probably_damaging(0.965) 48 FFPE AGCCA G/A GAACG CMDL150075 FLD0202 FLD0226 synonymous EGFR c.2583G>A c.2583G>A(p.%3D) ctG/ctA chr7 55259525 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259525", "IGV") medium 0.278 3216 no call pass 29443 EGFR_E00001681524_2 ENSG00000146648 21 of 28 47 FFPE AAACT G/A CTGGG CMDL150075 FLD0202 FLD0226 synonymous EGFR c.2598G>A c.2598G>A(p.%3D) gaG/gaA chr7 55259540 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259540", "IGV") medium 0.270 3216 no call pass 21433 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs397517133, COSM219793 likely_benign 32 FFPE GAAGA G/A AAAGA CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.2617G>A p.G873R Gga/Aga chr7 55259559 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259559", "IGV") medium 0.281 1588 no call pass 14760 EGFR_E00001681524_2 ENSG00000146648 21 of 28 deleterious(0) probably_damaging(0.997) 13 FFPE CAGAA G/A GAGGC CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.2618G>A p.G873E gGa/gAa chr7 55259560 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259560", "IGV") medium 0.367 1544 pass no call 18326 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM13199 tolerated(0.09) probably_damaging(0.989) 12 FFPE AGAAG G/A AGGCA CMDL150075 FLD0202 FLD0226 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.996 0.994 528 659 pass pass 22551 27704 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.2791G>A p.E931K Gaa/Aaa chr7 55266499 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266499", "IGV") low 0.189 1053 QD no call 1850 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(1) 53 FFPE AAGGA G/A AACGC CMDL150075 FLD0202 FLD0226 synonymous EGFR c.2796C>T c.2796C>T(p.%3D) cgC/cgT chr7 55266504 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266504", "IGV") medium 0.645 1053 pass no call 15971 EGFR_E00001779947_1 ENSG00000146648 23 of 28 48 FFPE GAACG C/T CTCCC CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.2800C>T p.P934S Cct/Tct chr7 55266508 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266508", "IGV") medium 0.647 1053 pass no call 15929 EGFR_E00001779947_1 ENSG00000146648 23 of 28 rs575565383, COSM3923814 deleterious(0.03) probably_damaging(1) T:0.0004 44 FFPE GCCTC C/T CTCAG CMDL150075 FLD0202 FLD0226 synonymous EGFR c.2784G>A c.2784G>A(p.%3D) gaG/gaA chr7 55266492 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266492", "IGV") medium 0.531 4256 no call pass 45859 EGFR_E00001779947_2 ENSG00000146648 23 of 28 16 FFPE CTGGA G/A AAAGG CMDL150075 FLD0202 FLD0226 synonymous EGFR c.2805G>A c.2805G>A(p.%3D) caG/caA chr7 55266513 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266513", "IGV") low 0.133 4257 no call QD 1275 EGFR_E00001779947_2 ENSG00000146648 23 of 28 37 FFPE CCTCA G/A CCACC CMDL150075 FLD0202 FLD0226 splice_region,intron EGFR c.2848+3G>A chr7 55266559 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266559", "IGV") medium 0.115 3653 pass no call 7606 EGFR_E00001779947_2 ENSG00000146648 23 of 27 65 FFPE AGTGT G/A AGTGA CMDL150075 FLD0202 FLD0226 intron EGFR c.2848+11G>A chr7 55266567 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266567", "IGV") medium 0.115 3653 pass no call 7606 EGFR_E00001779947_2 ENSG00000146648 23 of 27 57 FFPE TGACT G/A GTGGG CMDL150075 FLD0202 FLD0226 intron EGFR c.2848+20G>A chr7 55266576 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266576", "IGV") medium 0.113 3653 pass no call 7606 EGFR_E00001779947_2 ENSG00000146648 23 of 27 48 FFPE GGTCT G/A TCCAC CMDL150075 FLD0202 FLD0226 intron EGFR c.2849-25C>T chr7 55267984 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55267984", "IGV") medium 0.469 1056 no call pass 26941 EGFR_E00001790701_1 ENSG00000146648 23 of 27 26 FFPE TTGCA C/T TGTTT CMDL150075 FLD0202 FLD0226 intron EGFR c.2849-14C>T chr7 55267995 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55267995", "IGV") medium 0.467 2056 no call pass 26941 EGFR_E00001790701_1 ENSG00000146648 23 of 27 37 FFPE TTTCT C/T ATTCC CMDL150075 FLD0202 FLD0226 synonymous EGFR c.2904C>T c.2904C>T(p.%3D) ttC/ttT chr7 55268064 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268064", "IGV") medium 0.479 2056 no call pass 18580 EGFR_E00001790701_1 ENSG00000146648 24 of 28 COSM3412203, COSM39614 50 FFPE GAATT C/T TCCAA CMDL150075 FLD0202 FLD0226 intron EGFR c.2947-35G>A chr7 55268846 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268846", "IGV") medium 0.314 4851 no call pass 14206 EGFR_E00001801208_1 ENSG00000146648 24 of 27 rs766654453 22 FFPE TCTAC G/A GGCCA CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.2950G>A p.D984N Gat/Aat chr7 55268884 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268884", "IGV") low 0.125 4851 no call QD 1384 EGFR_E00001801208_1 ENSG00000146648 25 of 28 rs750582201, COSM506581 tolerated(0.22) benign(0.023) 60 FFPE AGGGG G/A ATGAA CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.2953G>A p.E985K Gaa/Aaa chr7 55268887 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268887", "IGV") medium 0.313 4851 no call pass 16697 EGFR_E00001801208_1 ENSG00000146648 25 of 28 deleterious(0.01) benign(0.42) 63 FFPE GGGAT G/A AAAGA CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.3010G>A p.E1004K Gaa/Aaa chr7 55268944 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268944", "IGV") low 0.127 4851 no call QD 526 EGFR_E00001801208_1 ENSG00000146648 25 of 28 deleterious(0.02) benign(0.37) 24 FFPE TGGAT G/A AAGAA CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.3043G>A p.E1015K Gag/Aag chr7 55268977 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268977", "IGV") medium 0.608 4788 pass no call 62119 EGFR_E00001801208_2 ENSG00000146648 25 of 28 deleterious(0) probably_damaging(0.991) 39 FFPE CCGAC G/A AGTAC CMDL150075 FLD0202 FLD0226 intron EGFR c.3114+18C>T chr7 55269066 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269066", "IGV") low 0.330 3655 no call QD 6544 EGFR_E00001801208_2 ENSG00000146648 25 of 27 13 FFPE TGTCT C/T TCTCT CMDL150075 FLD0202 FLD0226 intron EGFR c.3114+24C>T chr7 55269072 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269072", "IGV") low 0.324 3402 no call FS 15942 EGFR_E00001801208_2 ENSG00000146648 25 of 27 7 FFPE TCTCT C/T TCTCT CMDL150075 FLD0202 FLD0226 splice_region,intron EGFR c.2185-5C>T chr7 55242410 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55242410", "IGV") medium 0.228 4919 pass no call 10846 EGFR_Exon19 ENSG00000146648 18 of 27 rs368545090 16 FFPE TCTGT C/T ATAGG CMDL150075 FLD0202 FLD0226 synonymous EGFR c.2235G>A c.2235G>A(p.%3D) aaG/aaA chr7 55242465 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55242465", "IGV") medium 0.224 4919 pass no call 10103 EGFR_Exon19 ENSG00000146648 19 of 28 53 FFPE ATCAA G/A GAATT CMDL150075 FLD0202 FLD0226 nonsynonymous EGFR c.2272G>A p.E758K Gaa/Aaa chr7 55242502 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55242502", "IGV") medium 0.514 4450 no call pass 44536 EGFR_Exon19 ENSG00000146648 19 of 28 deleterious(0) probably_damaging(0.977) 16 FFPE ACAAG G/A AAATC CMDL150075 FLD0202 FLD0226 intron TP53 c.97-12A>G chr17 7579602 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7579602", "IGV") low 1.000 2 LowQual no call 22 EXP0116_TP53_E3 ENSG00000141510 3 of 10 26 FFPE ATGGG T/C GAAAA CMDL150075 FLD0202 FLD0226 synonymous TP53 c.129G>A c.129G>A(p.%3D) ttG/ttA chr17 7579558 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579558", "IGV") medium 0.211 393 no call pass 1147 EXP0116_TP53_E4 ENSG00000141510 4 of 11 rs754332870, TP53_g.11360del 49 FFPE AGCAT C/T AAATC CMDL150075 FLD0202 FLD0226 synonymous KRAS c.87G>A c.87G>A(p.%3D) gtG/gtA chr12 25398232 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398232", "IGV") low 0.142 2743 no call QD 425 KRAS_AA_HS ENSG00000133703 2 of 6 49 FFPE TCGTC C/T ACAAA CMDL150075 FLD0202 FLD0226 synonymous KRAS c.60G>A c.60G>A(p.%3D) acG/acA chr12 25398259 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398259", "IGV") medium 0.354 2743 no call pass 14608 KRAS_AA_HS ENSG00000133703 2 of 6 rs747140926, COSM1360871, COSM1360873, COSM1360870, COSM1360872 51 FFPE TGTAT C/T GTCAA CMDL150075 FLD0202 FLD0226 synonymous PIK3CA c.3174C>T c.3174C>T(p.%3D) atC/atT chr3 178952119 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178952119", "IGV") high 0.334 0.612 2758 2611 pass pass 13161 35181 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 62 FFPE TGGAT C/T TTCCA CMDL150075 FLD0202 FLD0226 3_prime_UTR PIK3CA c.*40C>T chr3 178952192 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178952192", "IGV") medium 0.612 1287 no call pass 29131 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 16 FFPE TTCCA C/T ACTGC CMDL150075 FLD0202 FLD0226 nonsynonymous PTEN c.850G>A p.E284K Gag/Aag chr10 89720699 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720699", "IGV") low 0.142 3251 no call QD 930 PTEN_E00001156315_5 ENSG00000171862 8 of 9 COSM28905, COSM5074 tolerated(0.2) benign(0.043) 24 FFPE GACCA G/A AGGAA CMDL150075 FLD0202 FLD0226 synonymous PTEN c.708C>T c.708C>T(p.%3D) gaC/gaT chr10 89717683 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717683", "IGV") low 0.140 4365 no call QD 264 PTEN_E00001156321_1 ENSG00000171862 7 of 9 24 FFPE GAAGA C/T AAGTT CMDL150075 FLD0202 FLD0226 nonsynonymous PTEN c.676T>C p.S226P Tcc/Ccc chr10 89717651 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89717651", "IGV") medium 0.594 456 pass no call 10969 PTEN_E00001156321_2 ENSG00000171862 7 of 9 tolerated(0.07) benign(0.015) 12 FFPE TATAT T/C CCTCC CMDL150075 FLD0202 FLD0226 nonsynonymous PTEN c.689G>A p.G230E gGa/gAa chr10 89717664 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717664", "IGV") medium 0.238 4042 no call pass 14197 PTEN_E00001156321_2 ENSG00000171862 7 of 9 COSM23550 tolerated(0.27) benign(0.016) 25 FFPE TTCAG G/A ACCCA CMDL150075 FLD0202 FLD0226 nonsynonymous PTEN c.698G>A p.R233Q cGa/cAa chr10 89717673 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717673", "IGV") medium 0.238 4042 no call pass 14205 PTEN_E00001156321_2 ENSG00000171862 7 of 9 rs770025422, COSM1297486 tolerated(0.12) benign(0.156) 34 FFPE CACAC G/A ACGGG CMDL150075 FLD0202 FLD0226 nonsynonymous PTEN c.707A>G p.D236G gAc/gGc chr10 89717682 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717682", "IGV") medium 0.374 911 pass no call 5241 PTEN_E00001156321_2 ENSG00000171862 7 of 9 tolerated(0.2) benign(0.005) 43 FFPE GGAAG A/G CAAGT CMDL150075 FLD0202 FLD0226 nonsynonymous PTEN c.742C>T p.P248S Cct/Tct chr10 89717717 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717717", "IGV") low 0.184 4042 no call QD 3489 PTEN_E00001156321_2 ENSG00000171862 7 of 9 tolerated(0.06) benign(0.309) 59 FFPE CGTTA C/T CTGTG CMDL150075 FLD0202 FLD0226 nonsynonymous PTEN c.754G>A p.D252N Gat/Aat chr10 89717729 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717729", "IGV") medium 0.587 911 pass no call 11066 PTEN_E00001156321_2 ENSG00000171862 7 of 9 COSM5246 deleterious(0) probably_damaging(0.955) 47 FFPE GTGGT G/A ATATC CMDL150075 FLD0202 FLD0226 nonsynonymous PTEN c.553C>T p.H185Y Cat/Tat chr10 89711935 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711935", "IGV") medium 0.992 244 pass no call 6048 PTEN_E00001156327_4 ENSG00000171862 6 of 9 COSM216385 deleterious(0.04) benign(0.001) 27 FFPE AGAAT C/T ATCTG CMDL150075 FLD0202 FLD0226 nonsynonymous PTEN c.277C>T p.H93Y Cat/Tat chr10 89692793 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692793", "IGV") medium 0.881 3368 no call pass 72455 PTEN_E00001156330_1 ENSG00000171862 5 of 9 CM983500, COSM5283, COSM5043 deleterious(0) probably_damaging(0.964) 26 FFPE AAGAC C/T ATAAC CMDL150075 FLD0202 FLD0226 nonsynonymous PTEN c.283C>T p.P95S Cca/Tca chr10 89692799 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692799", "IGV") medium 0.314 1506 pass no call 7094 PTEN_E00001156330_1 ENSG00000171862 5 of 9 COSM5136 deleterious(0.03) possibly_damaging(0.461) 32 FFPE ATAAC C/T CACCA CMDL150075 FLD0202 FLD0226 nonsynonymous PTEN c.362C>T p.A121V gCa/gTa chr10 89692878 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692878", "IGV") low 0.455 11 no call pass 152 PTEN_E00001156330_3 ENSG00000171862 5 of 9 rs121909237, COSM5273 tolerated(0.42) possibly_damaging(0.669) pathogenic 15 FFPE TGCAG C/T AATTC CMDL150075 FLD0202 FLD0226 intron PTEN c.253+9G>A chr10 89690855 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89690855", "IGV") medium 0.218 2518 pass no call 5124 PTEN_E00001156337_4 ENSG00000171862 4 of 8 47 FFPE GGTAT G/A AATGT CMDL150075 FLD0202 FLD0226 intron PTEN c.165-47C>T chr10 89685223 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89685223", "IGV") medium 0.673 664 pass no call 9403 PTEN_E00001156344_1 ENSG00000171862 2 of 8 24 FFPE GTTAG C/T TCATT CMDL150075 FLD0202 FLD0226 nonsynonymous PTEN c.142A>G p.N48D Aac/Gac chr10 89653844 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89653844", "IGV") low 0.500 3 no call LowQual 12 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM5050, COSM428080 deleterious(0) probably_damaging(0.955) 53 FFPE ACAGG A/G ACAAT CMDL150075 FLD0202 FLD0226 intron PTEN c.1027-13T>C chr10 89725031 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89725031", "IGV") low 0.132 3494 no call QD 549 PTEN_E00001456541_1 ENSG00000171862 8 of 8 9 FFPE TAAAT T/C TTCTT CMDL150075 FLD0202 FLD0226 nonsynonymous PTEN c.1133G>A p.R378K aGa/aAa chr10 89725150 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725150", "IGV") low 0.188 3699 no call QD 3759 PTEN_E00001456541_2 ENSG00000171862 9 of 9 tolerated_low_confidence(0.13) benign(0.159) 62 FFPE TTATA G/A ATATT CMDL150075 FLD0202 FLD0226 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") high 0.998 0.997 503 1594 pass pass 21081 70347 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150075 FLD0202 FLD0226 intron TP53 c.672+60C>T chr17 7578117 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578117", "IGV") low 0.115 1594 no call QD 2615 TP53_E00001255919_1 ENSG00000141510 6 of 10 8 FFPE ACCTG G/A AGGGC CMDL150075 FLD0202 FLD0226 intron TP53 c.672+56C>T chr17 7578121 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578121", "IGV") medium 0.751 1594 no call pass 45524 TP53_E00001255919_1 ENSG00000141510 6 of 10 12 FFPE GGAGG G/A CCACT CMDL150075 FLD0202 FLD0226 stop_gained TP53 c.574C>T p.Q192* Cag/Tag chr17 7578275 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578275", "IGV") medium 0.427 1830 pass no call 13867 TP53_E00001255919_3 ENSG00000141510 6 of 11 TP53_g.12643C>A, TP53_g.12643C>T, COSM10733, COSM44111, COSM117949, COSM117946, COSM117947, COSM3370929, COSM1649390, COSM117948 26 FFPE ATGCT G/A AGGAG CMDL150075 FLD0202 FLD0226 synonymous TP53 c.504C>T c.504C>T(p.%3D) caC/caT chr17 7578426 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578426", "IGV") low 0.116 1855 QD no call 349 TP53_E00001255919_5 ENSG00000141510 5 of 11 rs746293837, TP53_g.12492del, TP53_g.12492C>G, TP53_g.12492C>A, TP53_g.12492C>T, COSM45479, COSM46299, COSM44663 48 FFPE GTCAT G/A TGCTG CMDL150075 FLD0202 FLD0226 synonymous TP53 c.483C>T c.483C>T(p.%3D) gcC/gcT chr17 7578447 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578447", "IGV") medium 0.117 1855 pass no call 3860 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12471del, TP53_g.12471C>T, COSM44119 62 FFPE TAGAT G/A GCCAT CMDL150075 FLD0202 FLD0226 synonymous TP53 c.477C>T c.477C>T(p.%3D) gcC/gcT chr17 7578453 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578453", "IGV") low 0.143 3796 no call QD 576 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12465C>T, TP53_g.12465del, COSM44130 9 FFPE GCCAT G/A GCGCG CMDL150075 FLD0202 FLD0226 synonymous TP53 c.393C>T c.393C>T(p.%3D) aaC/aaT chr17 7578537 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578537", "IGV") low 0.082 3796 no call QD 1896 TP53_E00001255919_6 ENSG00000141510 5 of 11 rs769270327, TP53_g.12381C>T, TP53_g.12381C>G, TP53_g.12381C>A, COSM45978, COSM44291, COSM44138, COSM100015, COSM100018, COSM100016, COSM100017 37 FFPE ATCTT G/A TTGAG CMDL150075 FLD0202 FLD0226 nonsynonymous TP53 c.382C>T p.P128S Cct/Tct chr17 7578548 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578548", "IGV") low 0.081 3796 no call QD 1659 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12370del, TP53_g.12370C>G, TP53_g.12370C>T, COSM44396, COSM44397, COSM44734 deleterious(0.03) probably_damaging(0.987) 26 FFPE GGCAG G/A GGAGT CMDL150075 FLD0202 FLD0226 synonymous TP53 c.381C>T c.381C>T(p.%3D) tcC/tcT chr17 7578549 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578549", "IGV") low 0.082 3796 no call QD 1874 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12369C>T, TP53_g.12369C>G, COSM45337 25 FFPE GCAGG G/A GAGTA CMDL150075 FLD0202 FLD0226 intron TP53 c.376-10C>T chr17 7578564 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578564", "IGV") medium 0.487 3194 pass no call 28382 TP53_E00001255919_6 ENSG00000141510 4 of 10 TP53_g.12354C>T, COSM46116 10 FFPE AGGAA G/A AGGAA CMDL150075 FLD0202 FLD0226 intron TP53 c.74+56C>T chr17 7579783 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579783", "IGV") medium 0.567 820 pass no call 16778 TP53_E00001596491_1 ENSG00000141510 2 of 10 6 FFPE TGCTA G/A GGGGC CMDL150075 FLD0202 FLD0226 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") medium 0.998 1635 pass no call 51661 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150075 FLD0202 FLD0226 nonsynonymous TP53 c.292C>T p.P98S Cct/Tct chr17 7579395 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579395", "IGV") medium 0.424 1839 no call pass 13771 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11523C>T, COSM12296, COSM1386881, COSM1386882 deleterious(0) probably_damaging(1) 11 FFPE GGAAG G/A GACAG CMDL150075 FLD0202 FLD0226 nonsynonymous TP53 c.242C>T p.T81I aCa/aTa chr17 7579445 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579445", "IGV") medium 0.430 1254 pass no call 9385 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11473C>T, COSM44200 tolerated(0.21) benign(0.001) 56 FFPE CCGGT G/A TAGGA CMDL150075 FLD0202 FLD0226 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.998 0.997 1254 2550 pass pass 35869 82830 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150075 FLD0202 FLD0226 synonymous TP53 c.213C>T c.213C>T(p.%3D) ccC/ccT chr17 7579474 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579474", "IGV") low 0.079 2550 no call QD 616 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11444C>T 27 FFPE ACGGG G/A GGAGC CMDL150075 FLD0202 FLD0226 nonsynonymous TP53 c.743G>A p.R248Q cGg/cAg chr17 7577538 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577538", "IGV") medium 0.993 4325 pass no call 119216 TP53_E00001665758_1 25032700, 20377871, 18798306, 15450681, 25105660, 21264207 ENSG00000141510 7 of 11 rs11540652, CM920675, TP53_g.13380G>A, TP53_g.13380G>C, TP53_g.13380G>T, TP53_g.13380del, COSM10662, COSM11491, COSM6549, COSM46135, COSM340105, COSM99602, COSM241995, COSM99020, COSM241994, COSM340106, COSM3356964, COSM3378346, COSM1640830, COSM1646857, COSM1646858, COSM99021, COSM241996, COSM340107 deleterious(0) probably_damaging(1) pathogenic 74 FFPE GCCTC C/T GGTTC CMDL150075 FLD0202 FLD0226 nonsynonymous TP53 c.725G>A p.C242Y tGc/tAc chr17 7577556 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577556", "IGV") medium 0.547 4325 pass no call 47651 TP53_E00001665758_1 ENSG00000141510 7 of 11 CM910618, rs121912655, TP53_g.13362G>A, TP53_g.13362G>T, TP53_g.13362G>C, COSM11133, COSM10810, COSM10646, COSM251397, COSM129834, COSM1610838, COSM1610839, COSM251396, COSM129835, COSM3403262, COSM3717642, COSM3378347, COSM2744611, COSM1646852, COSM2744612, COSM1610840, COSM129836, COSM251398 deleterious(0) probably_damaging(1) pathogenic 56 FFPE CCATG C/T AGGAA CMDL150075 FLD0202 FLD0226 nonsynonymous TP53 c.722C>T p.S241F tCc/tTc chr17 7577559 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577559", "IGV") medium 0.674 4142 no call pass 61579 TP53_E00001665758_1 25105660, 21264207 ENSG00000141510 7 of 11 rs28934573, CM920673, TP53_g.13359C>A, TP53_g.13359del, TP53_g.13359C>T, TP53_g.13359C>G, COSM10709, COSM10812, COSM10935, COSM44657, COSM214171, COSM437501, COSM1230110, COSM1230111, COSM214170, COSM437502, COSM3712577, COSM3362448, COSM3522695, COSM2744620, COSM1649402, COSM2744619, COSM214172, COSM437503, COSM1230112 deleterious(0) probably_damaging(1) likely_pathogenic,pathogenic 53 FFPE TGCAG G/A AACTG CMDL150075 FLD0202 FLD0226 nonsynonymous TP53 c.686G>A p.C229Y tGt/tAt chr17 7577595 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577595", "IGV") medium 0.209 2027 no call pass 10814 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13323G>T, TP53_g.13323G>C, TP53_g.13323G>A, COSM44313, COSM45974, COSM308322, COSM308324, COSM308323, COSM308325 tolerated(0.66) benign(0.138) 17 FFPE TGGTA C/T AGTCA CMDL150075 FLD0202 FLD0226 synonymous TP53 c.1071G>A c.1071G>A(p.%3D) aaG/aaA chr17 7573956 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573956", "IGV") medium 0.720 1956 no call pass 31664 TP53_E00001728015_1 ENSG00000141510 10 of 11 76 FFPE GGCTC C/T TTCCC CMDL150075 FLD0202 FLD0226 nonsynonymous TP53 c.1036G>A p.E346K Gag/Aag chr17 7573991 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573991", "IGV") medium 0.281 1956 no call pass 6942 TP53_E00001728015_1 ENSG00000141510 10 of 11 TP53_g.16927G>T, COSM44083, COSM1522201 deleterious(0.01) probably_damaging(0.952) 46 FFPE GGCCT C/T ATTCA CMDL150075 FLD0202 FLD0226 3_prime_UTR TP53 c.*20C>T chr17 7572907 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572907", "IGV") medium 0.960 1110 pass no call 29146 TP53_E00001757276_1 ENSG00000141510 11 of 11 38 FFPE AGTGG G/A GAACA CMDL150075 FLD0202 FLD0226 intron TP53 c.993+42G>A chr17 7576811 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576811", "IGV") medium 0.303 1751 pass no call 16843 TP53_E00001789298_1 ENSG00000141510 9 of 10 5 FFPE TTAGA C/T TGGAA CMDL150075 FLD0202 FLD0226 intron TP53 c.993+39C>T chr17 7576814 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576814", "IGV") medium 0.205 1751 pass no call 9383 TP53_E00001789298_1 ENSG00000141510 9 of 10 8 FFPE GACTG G/A AAACT CMDL150075 FLD0202 FLD0226 nonsynonymous TP53 c.946C>T p.P316S Ccc/Tcc chr17 7576900 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576900", "IGV") medium 0.986 539 no call pass 15150 TP53_E00001789298_1 ENSG00000141510 9 of 11 rs772773208, TP53_g.14018del, TP53_g.14018C>A tolerated(0.25) benign(0.088) 64 FFPE CTGGG G/A AGAGG CMDL150075 FLD0202 FLD0226 synonymous TP53 c.915G>A c.915G>A(p.%3D) aaG/aaA chr17 7577023 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577023", "IGV") medium 0.353 4534 no call pass 25042 TP53_E00001789298_2 ENSG00000141510 8 of 11 TP53_g.13895G>A, TP53_g.13895G>T, TP53_g.13895G>C, COSM44345, COSM46382, COSM45400, COSM1386583 33 FFPE CCTCG C/T TTAGT CMDL150075 FLD0202 FLD0226 nonsynonymous TP53 c.839G>A p.R280K aGa/aAa chr17 7577099 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577099", "IGV") medium 0.361 1708 no call pass 8913 TP53_E00001789298_3 ENSG00000141510 8 of 11 CM993218, rs121912660, TP53_g.13819G>C, TP53_g.13819G>T, TP53_g.13819G>A, COSM10724, COSM11287, COSM10728, COSM562340, COSM129830, COSM254987, COSM3522694, COSM3733332, COSM3723939, COSM1659144, COSM1646813, COSM1649340 deleterious(0.04) possibly_damaging(0.83) uncertain_significance,pathogenic 68 FFPE GGTCT C/T TCCCA CMDL150075 FLD0202 FLD0226 nonsynonymous TP53 c.836G>A p.G279E gGg/gAg chr17 7577102 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577102", "IGV") low 0.136 1273 QD no call 193 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13816G>T, TP53_g.13816G>A, COSM43714, COSM46032, COSM99732, COSM3701289, COSM3701288 deleterious(0) probably_damaging(0.999) 65 FFPE CTCTC C/T CAGGA CMDL150075 FLD0202 FLD0226 nonsynonymous TP53 c.835G>A p.G279R Ggg/Agg chr17 7577103 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577103", "IGV") medium 0.273 1273 pass no call 5035 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13815G>T, TP53_g.13815G>A, TP53_g.13815G>C, TP53_g.13815del, COSM44603, COSM46298, COSM43674, COSM44005, COSM417973, COSM99755, COSM1386597 deleterious(0) probably_damaging(0.999) 64 FFPE TCTCC C/T AGGAC CMDL150079 FLD0203 FLD0227 splice_region,intron EGFR c.2284-7C>T chr7 55248979 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248979", "IGV") medium 0.881 1451 pass no call 33426 EGFR_E00001601336_1 ENSG00000146648 19 of 27 59 FFPE CCCTC C/T CTCCA CMDL150079 FLD0203 FLD0227 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") medium 0.979 701 pass no call 29015 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150079 FLD0203 FLD0227 synonymous EGFR c.2382C>T c.2382C>T(p.%3D) ccC/ccT chr7 55249084 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249084", "IGV") medium 0.882 701 pass no call 24109 EGFR_E00001601336_1 ENSG00000146648 20 of 28 9 FFPE ATGCC C/T TTCGG CMDL150079 FLD0203 FLD0227 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.301 0.202 2073 254 pass pass 18116 1161 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150079 FLD0203 FLD0227 nonsynonymous EGFR c.2648T>C p.L883S tTg/tCg chr7 55260481 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55260481", "IGV") medium 0.384 4598 no call pass 29309 EGFR_E00001631695_1 ENSG00000146648 22 of 28 deleterious(0) probably_damaging(1) 72 FFPE GGCAT T/C GGAAT CMDL150079 FLD0203 FLD0227 synonymous EGFR c.2499G>A c.2499G>A(p.%3D) ttG/ttA chr7 55259441 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259441", "IGV") medium 0.301 4627 no call pass 25820 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM219794 70 FFPE CGCTT G/A GTGCA CMDL150079 FLD0203 FLD0227 synonymous EGFR c.2508C>T c.2508C>T(p.%3D) cgC/cgT chr7 55259450 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259450", "IGV") high 0.812 0.387 5196 4627 pass pass 102183 35227 EGFR_E00001681524_1 17956637, 21264207, 23093229, 22192147, 23211371, 21869887, 16324836 ENSG00000146648 21 of 28 rs2229066, COSM85893 benign T:0.0054 76 FFPE CACCG C/T GACCT CMDL150079 FLD0203 FLD0227 synonymous EGFR c.2478C>T c.2478C>T(p.%3D) aaC/aaT chr7 55259420 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259420", "IGV") medium 0.136 1485 pass no call 3587 EGFR_E00001681524_2 ENSG00000146648 21 of 28 4 FFPE ATGAA C/T TACTT CMDL150079 FLD0203 FLD0227 synonymous EGFR c.2484G>A c.2484G>A(p.%3D) ttG/ttA chr7 55259426 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259426", "IGV") medium 0.164 1716 no call pass 6157 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs727504312, COSM3639750 likely_benign 10 FFPE TACTT G/A GAGGA CMDL150079 FLD0203 FLD0227 nonsynonymous EGFR c.2507G>A p.R836H cGc/cAc chr7 55259449 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259449", "IGV") medium 0.207 3456 no call pass 7334 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs146121458, COSM133566 deleterious(0) probably_damaging(0.997) 33 FFPE GCACC G/A CGACC CMDL150079 FLD0203 FLD0227 synonymous EGFR c.2508C>T c.2508C>T(p.%3D) cgC/cgT chr7 55259450 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259450", "IGV") high 0.566 0.400 2977 3456 pass pass 34788 25443 EGFR_E00001681524_2 17956637, 21264207, 23093229, 22192147, 23211371, 21869887, 16324836 ENSG00000146648 21 of 28 rs2229066, COSM85893 benign T:0.0054 34 FFPE CACCG C/T GACCT CMDL150079 FLD0203 FLD0227 nonsynonymous EGFR c.2611G>A p.A871T Gca/Aca chr7 55259553 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259553", "IGV") medium 0.328 1726 no call pass 17492 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM28605 deleterious(0) probably_damaging(0.966) 19 FFPE ACCAT G/A CAGAA CMDL150079 FLD0203 FLD0227 intron EGFR c.3115-60G>A chr7 55269368 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269368", "IGV") medium 0.468 4591 pass no call 46948 EGFR_E00001773562_1 ENSG00000146648 25 of 27 14 FFPE TTCAG G/A AAAAG CMDL150079 FLD0203 FLD0227 intron EGFR c.3115-41G>A chr7 55269387 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269387", "IGV") medium 0.473 4591 pass no call 47519 EGFR_E00001773562_1 ENSG00000146648 25 of 27 33 FFPE ATGTG G/A TACAA CMDL150079 FLD0203 FLD0227 nonsynonymous,splice_region EGFR c.3161G>A p.G1054E gGg/gAg chr7 55269474 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269474", "IGV") low 0.197 5205 no call QD 7060 EGFR_E00001773562_1 ENSG00000146648 26 of 28 deleterious(0) probably_damaging(1) 21 FFPE AAATG G/A GGTAT CMDL150079 FLD0203 FLD0227 intron EGFR c.3162+9G>A chr7 55269484 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269484", "IGV") medium 0.467 4795 pass no call 40170 EGFR_E00001773562_1 ENSG00000146648 26 of 27 11 FFPE TGTAT G/A AACAC CMDL150079 FLD0203 FLD0227 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.996 0.995 2012 2058 pass pass 85133 86863 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150079 FLD0203 FLD0227 synonymous EGFR c.2832C>T c.2832C>T(p.%3D) taC/taT chr7 55266540 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266540", "IGV") low 0.141 3629 QD no call 212 EGFR_E00001779947_2 ENSG00000146648 23 of 28 64 FFPE GTCTA C/T ATGAT CMDL150079 FLD0203 FLD0227 intron EGFR c.2848+47G>A chr7 55266603 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266603", "IGV") medium 0.502 3927 no call pass 37334 EGFR_E00001779947_2 ENSG00000146648 23 of 27 21 FFPE TTGGT G/A GCTGC CMDL150079 FLD0203 FLD0227 nonsynonymous EGFR c.2875C>T p.P959S Cca/Tca chr7 55268035 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268035", "IGV") medium 0.917 3105 no call pass 118900 EGFR_E00001790701_1 ENSG00000146648 24 of 28 deleterious(0) probably_damaging(1) 77 FFPE GTCGC C/T CAAAG CMDL150079 FLD0203 FLD0227 nonsynonymous EGFR c.2876C>T p.P959L cCa/cTa chr7 55268036 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268036", "IGV") medium 0.920 3105 no call pass 118900 EGFR_E00001790701_1 ENSG00000146648 24 of 28 deleterious(0) probably_damaging(1) 78 FFPE TCGCC C/T AAAGT CMDL150079 FLD0203 FLD0227 intron EGFR c.2947-45G>A chr7 55268836 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268836", "IGV") medium 0.269 2886 no call pass 21144 EGFR_E00001801208_1 ENSG00000146648 24 of 27 rs765037530 12 FFPE GAATA G/A CATCT CMDL150079 FLD0203 FLD0227 splice_region,intron EGFR c.2947-4C>T chr7 55268877 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268877", "IGV") low 0.174 5739 no call QD 5215 EGFR_E00001801208_1 ENSG00000146648 24 of 27 53 FFPE CTGCA C/T CAGGG CMDL150079 FLD0203 FLD0227 synonymous EGFR c.3045G>A c.3045G>A(p.%3D) gaG/gaA chr7 55268979 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268979", "IGV") medium 0.393 4602 no call pass 28984 EGFR_E00001801208_2 ENSG00000146648 25 of 28 41 FFPE GACGA G/A TACCT CMDL150079 FLD0203 FLD0227 synonymous EGFR c.2223C>T c.2223C>T(p.%3D) ccC/ccT chr7 55242453 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55242453", "IGV") low 0.140 5907 QD no call 1750 EGFR_Exon19 ENSG00000146648 19 of 28 rs372772241 59 FFPE ATTCC C/T GTCGC CMDL150079 FLD0203 FLD0227 nonsynonymous EGFR c.2255C>T p.S752F tCt/tTt chr7 55242485 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55242485", "IGV") medium 0.140 5907 pass no call 17207 EGFR_Exon19 ENSG00000146648 19 of 28 rs121913464, COSM13186, COSM4170219 deleterious(0) probably_damaging(1) 33 FFPE AACAT C/T TCCGA CMDL150079 FLD0203 FLD0227 nonsynonymous EGFR c.2264C>T p.A755V gCc/gTc chr7 55242494 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55242494", "IGV") high 0.141 0.218 5907 5731 pass pass 17305 11476 EGFR_Exon19 ENSG00000146648 19 of 28 deleterious(0.02) probably_damaging(0.999) 24 FFPE GAAAG C/T CAACA CMDL150079 FLD0203 FLD0227 intron TP53 c.97-33G>A chr17 7579623 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579623", "IGV") medium 0.732 223 pass no call 3459 EXP0116_TP53_E3 ENSG00000141510 3 of 10 47 FFPE AGGAC C/T AGGTC CMDL150079 FLD0203 FLD0227 synonymous TP53 c.126T>C c.126T>C(p.%3D) gaT/gaC chr17 7579561 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7579561", "IGV") low 0.157 5433 no call QD 3939 EXP0116_TP53_E4 ENSG00000141510 4 of 11 46 FFPE ATCAA A/G TCATC CMDL150079 FLD0203 FLD0227 synonymous TP53 c.105G>A c.105G>A(p.%3D) ttG/ttA chr17 7579582 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579582", "IGV") medium 0.185 2614 pass no call 7863 EXP0116_TP53_E4 ENSG00000141510 4 of 11 rs121912661, TP53_g.11336G>C, TP53_g.11336G>T, COSM46160, COSM45193 uncertain_significance,pathogenic 25 FFPE GACGG C/T AAGGG CMDL150079 FLD0203 FLD0227 nonsynonymous KRAS c.22G>A p.V8I Gta/Ata chr12 25398297 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398297", "IGV") medium 0.939 3468 no call pass 84505 KRAS_AA_HS ENSG00000133703 2 of 6 tolerated(0.08) possibly_damaging(0.69) 13 FFPE AACTA C/T CACAA CMDL150079 FLD0203 FLD0227 splice_acceptor PIK3CA c.1540-1G>A chr3 178935997 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178935997", "IGV") low 0.884 43 no call pass 1428 PIK3CA_Ex10_gap ENSG00000121879 9 of 20 COSM1726693, COSM1726692 33 FFPE TTACA G/A AGTAA CMDL150079 FLD0203 FLD0227 nonsynonymous PIK3CA c.3133G>A p.D1045N Gat/Aat chr3 178952078 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178952078", "IGV") low 0.154 4657 no call QD 1570 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 COSM25086, COSM1421002 tolerated(0.17) benign(0.287) 21 FFPE TGAAT G/A ATGCA CMDL150079 FLD0203 FLD0227 nonsynonymous PIK3CA c.3165G>A p.M1055I atG/atA chr3 178952110 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178952110", "IGV") medium 0.473 4661 no call pass 42087 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 tolerated(0.52) benign(0.006) 53 FFPE AAAAT G/A GATTG CMDL150079 FLD0203 FLD0227 synonymous PIK3CA c.3174C>T c.3174C>T(p.%3D) atC/atT chr3 178952119 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178952119", "IGV") medium 0.186 4851 pass no call 14358 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 62 FFPE TGGAT C/T TTCCA CMDL150079 FLD0203 FLD0227 stop_gained PIK3CA c.3190C>T p.Q1064* Cag/Tag chr3 178952135 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178952135", "IGV") medium 0.189 4851 pass no call 21784 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 73 FFPE TTAAA C/T AGCAT CMDL150079 FLD0203 FLD0227 3_prime_UTR PIK3CA c.*37C>T chr3 178952189 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178952189", "IGV") medium 0.189 2441 pass no call 8519 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 19 FFPE GGATT C/T CACAC CMDL150079 FLD0203 FLD0227 intron PTEN c.802-85C>T chr10 89720566 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720566", "IGV") medium 0.264 1715 pass no call 8830 PTEN_E00001156315_1m ENSG00000171862 7 of 8 86 FFPE GGTGA C/T AGATT CMDL150079 FLD0203 FLD0227 nonsynonymous PTEN c.887G>A p.C296Y tGt/tAt chr10 89720736 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720736", "IGV") low 0.084 2947 QD no call 968 PTEN_E00001156315_7 ENSG00000171862 8 of 9 tolerated(1) benign(0.116) 4 FFPE TCTAT G/A TGATC CMDL150079 FLD0203 FLD0227 nonsynonymous PTEN c.928G>A p.D310N Gat/Aat chr10 89720777 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720777", "IGV") medium 0.230 5922 pass no call 13598 PTEN_E00001156315_7 ENSG00000171862 8 of 9 tolerated(0.13) benign(0.31) 45 FFPE GTGCA G/A ATAAT CMDL150079 FLD0203 FLD0227 nonsynonymous,splice_region PTEN c.637C>T p.P213S Cct/Tct chr10 89717612 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717612", "IGV") medium 0.240 4214 pass no call 8917 PTEN_E00001156321_1 ENSG00000171862 7 of 9 COSM30729 tolerated(0.07) benign(0.292) 42 FFPE CAGAT C/T CTCAG CMDL150079 FLD0203 FLD0227 intron PTEN c.801+151G>A chr10 89717927 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717927", "IGV") medium 0.151 1168 no call pass 3127 PTEN_E00001156321_4m ENSG00000171862 7 of 8 7 FFPE ATAAG G/A GTAAA CMDL150079 FLD0203 FLD0227 nonsynonymous PTEN c.553C>T p.H185Y Cat/Tat chr10 89711935 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711935", "IGV") low 0.170 4808 no call QD 3963 PTEN_E00001156327_4 ENSG00000171862 6 of 9 COSM216385 deleterious(0.04) benign(0.001) 27 FFPE AGAAT C/T ATCTG CMDL150079 FLD0203 FLD0227 splice_region,intron PTEN c.634+5G>A chr10 89712021 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89712021", "IGV") medium 0.361 4802 no call pass 29487 PTEN_E00001156327_4 ENSG00000171862 6 of 8 CS010097, rs138336847, CS991491, COSM5944, COSM1577266 29 FFPE AGTAA G/A TGCTT CMDL150079 FLD0203 FLD0227 intron PTEN c.634+30G>A chr10 89712046 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89712046", "IGV") medium 0.361 2385 no call pass 28940 PTEN_E00001156327_4 ENSG00000171862 6 of 8 4 FFPE TCCAT G/A TATTG CMDL150079 FLD0203 FLD0227 nonsynonymous PTEN c.331T>C p.W111R Tgg/Cgg chr10 89692847 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89692847", "IGV") medium 0.268 5475 no call pass 20077 PTEN_E00001156330_1 ENSG00000171862 5 of 9 rs398123321, CM014084, COSM5121 deleterious(0) probably_damaging(0.954) likely_pathogenic 52 FFPE ACCAA T/C GGCTA CMDL150079 FLD0203 FLD0227 synonymous PTEN c.369C>T c.369C>T(p.%3D) caC/caT chr10 89692885 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692885", "IGV") low 0.214 5475 no call QD 10235 PTEN_E00001156330_1 ENSG00000171862 5 of 9 CM1010010 14 FFPE ATTCA C/T TGTAA CMDL150079 FLD0203 FLD0227 intron PTEN c.165-64G>A chr10 89685206 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89685206", "IGV") medium 0.377 557 pass no call 6860 PTEN_E00001156344_1 ENSG00000171862 2 of 8 7 FFPE TTAAT G/A TAATT CMDL150079 FLD0203 FLD0227 intron PTEN c.165-29G>A chr10 89685241 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89685241", "IGV") low 0.196 1122 QD no call 1861 PTEN_E00001156344_1 ENSG00000171862 2 of 8 42 FFPE ATGGT G/A GCTTT CMDL150079 FLD0203 FLD0227 synonymous PTEN c.1080C>T c.1080C>T(p.%3D) agC/agT chr10 89725097 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725097", "IGV") medium 0.168 1900 pass no call 7331 PTEN_E00001456541_2 ENSG00000171862 9 of 9 9 FFPE GCTAG C/T AGTTC CMDL150079 FLD0203 FLD0227 nonsynonymous PTEN c.1084T>C p.S362P Tca/Cca chr10 89725101 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89725101", "IGV") low 0.102 2979 no call QD 2890 PTEN_E00001456541_2 ENSG00000171862 9 of 9 tolerated(0.08) benign(0.014) 13 FFPE GCAGT T/C CAACT CMDL150079 FLD0203 FLD0227 nonsynonymous PTEN c.1160C>T p.P387L cCa/cTa chr10 89725177 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725177", "IGV") low 0.168 3702 QD no call 3570 PTEN_E00001456541_2 ENSG00000171862 9 of 9 deleterious_low_confidence(0.01) benign(0.282) 64 FFPE TGATC C/T AGAGA CMDL150079 FLD0203 FLD0227 nonsynonymous PTEN c.1177G>A p.D393N Gat/Aat chr10 89725194 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725194", "IGV") low 0.144 3702 QD no call 101 PTEN_E00001456541_2 ENSG00000171862 9 of 9 tolerated_low_confidence(0.09) benign(0.425) 47 FFPE CTTTT G/A ATGAA CMDL150079 FLD0203 FLD0227 synonymous PTEN c.1209C>T c.1209C>T(p.%3D) gtC/gtT chr10 89725226 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725226", "IGV") low 0.095 2803 no call QD 2550 PTEN_E00001456541_2 ENSG00000171862 9 of 9 15 FFPE AAAGT C/T TGAAT CMDL150079 FLD0203 FLD0227 nonsynonymous PTEN c.29G>A p.S10N aGc/aAc chr10 89624255 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624255", "IGV") medium 0.193 4145 pass no call 8955 PTEN_E00001456562_1 ENSG00000171862 1 of 9 COSM5049, COSM1349462 deleterious(0) possibly_damaging(0.847) 61 FFPE CGTTA G/A CAGAA CMDL150079 FLD0203 FLD0227 synonymous PTEN c.30C>T c.30C>T(p.%3D) agC/agT chr10 89624256 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624256", "IGV") low 0.213 4354 no call QD 8065 PTEN_E00001456562_1 ENSG00000171862 1 of 9 COSM1349463, COSM3967199 62 FFPE GTTAG C/T AGAAA CMDL150079 FLD0203 FLD0227 synonymous PTEN c.54G>A c.54G>A(p.%3D) gaG/gaA chr10 89624280 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624280", "IGV") low 0.188 4145 QD no call 8225 PTEN_E00001456562_1 ENSG00000171862 1 of 9 73 FFPE CAAGA G/A GATGG CMDL150079 FLD0203 FLD0227 splice_donor PTEN c.79+1G>A chr10 89624306 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624306", "IGV") low 0.195 4145 QD no call 4699 PTEN_E00001456562_1 ENSG00000171862 1 of 8 47 FFPE GACCT G/A TATCC CMDL150079 FLD0203 FLD0227 intron PTEN c.79+37G>A chr10 89624342 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624342", "IGV") medium 0.187 2026 pass no call 8062 PTEN_E00001456562_1 ENSG00000171862 1 of 8 11 FFPE TTTCT G/A TCACT CMDL150079 FLD0203 FLD0227 intron TP53 c.993+211C>T chr17 7576642 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576642", "IGV") low 0.149 4888 no call QD 1413 TP53_00001404886_13 ENSG00000141510 9 of 10 35 FFPE TTTTT G/A AAAGC CMDL150079 FLD0203 FLD0227 intron TP53 c.672+35G>A chr17 7578142 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578142", "IGV") low 0.168 2532 QD no call 1711 TP53_E00001255919_1 ENSG00000141510 6 of 10 rs587778001 not_provided 33 FFPE CTTAA C/T CCCTC CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.626G>A p.R209K aGa/aAa chr17 7578223 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578223", "IGV") low 0.172 2532 QD no call 2165 TP53_E00001255919_1 ENSG00000141510 6 of 11 TP53_g.12695G>T, TP53_g.12695G>C, TP53_g.12695del, TP53_g.12695G>A, COSM45438, COSM45257, COSM46120, COSM45995, COSM308315, COSM984931, COSM308314, COSM984933, COSM308316, COSM984935, COSM308317, COSM984934 tolerated(0.91) benign(0.003) 30 FFPE TGTTT C/T TGTCA CMDL150079 FLD0203 FLD0227 synonymous TP53 c.618G>A c.618G>A(p.%3D) ttG/ttA chr17 7578231 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578231", "IGV") medium 0.251 2532 pass no call 7461 TP53_E00001255919_1 ENSG00000141510 6 of 11 TP53_g.12687G>C, TP53_g.12687G>A, COSM44797, COSM44414 22 FFPE TCATC C/T AAATA CMDL150079 FLD0203 FLD0227 intron TP53 c.560-33C>T chr17 7578322 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578322", "IGV") medium 0.295 3706 pass no call 15172 TP53_E00001255919_3 ENSG00000141510 5 of 10 68 FFPE GCCTG G/A GGACC CMDL150079 FLD0203 FLD0227 synonymous TP53 c.477C>T c.477C>T(p.%3D) gcC/gcT chr17 7578453 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578453", "IGV") low 0.199 3215 no call QD 4526 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12465C>T, TP53_g.12465del, COSM44130 56 FFPE GCCAT G/A GCGCG CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.449C>T p.T150I aCa/aTa chr17 7578481 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578481", "IGV") medium 0.615 3423 pass no call 43767 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12437C>T, TP53_g.12437C>A, TP53_g.12437C>G, COSM44038, COSM45563, COSM45139 deleterious(0.03) benign(0.144) 28 FFPE GGGGT G/A TGGAA CMDL150079 FLD0203 FLD0227 synonymous TP53 c.435G>A c.435G>A(p.%3D) ctG/ctA chr17 7578495 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578495", "IGV") medium 0.452 3215 no call pass 26294 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12423G>C, TP53_g.12423G>T, TP53_g.12423del, TP53_g.12423G>A, COSM45621, COSM45994 14 FFPE ACCCA C/T AGCTG CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.442G>A p.D148N Gat/Aat chr17 7578488 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578488", "IGV") low 0.216 3706 QD no call 7123 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12430del, TP53_g.12430G>A, TP53_g.12430G>T, COSM44043, COSM46105, COSM95383, COSM45913 tolerated(0.44) benign(0.003) 44 FFPE GGAAT C/T AACCC CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.404G>A p.C135Y tGc/tAc chr17 7578526 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578526", "IGV") medium 0.218 2855 no call pass 6284 TP53_E00001255919_6 ENSG00000141510 5 of 11 rs587781991, TP53_g.12392del, TP53_g.12392G>A, TP53_g.12392G>T, TP53_g.12392G>C, COSM10801, COSM10647, COSM44643, COSM300819, COSM303850, COSM99601, COSM300818, COSM99598, COSM303849, COSM303851, COSM99599, COSM300820, COSM3820723, COSM3932747, COSM3691869, COSM1750372, COSM2744946, COSM2744945, COSM99600, COSM303852, COSM300821 deleterious(0) probably_damaging(1) uncertain_significance 48 FFPE GTTGG C/T AAAAC CMDL150079 FLD0203 FLD0227 splice_acceptor TP53 c.376-1G>A chr17 7578555 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578555", "IGV") medium 0.216 2855 no call pass 5945 TP53_E00001255919_6 ENSG00000141510 4 of 10 TP53_g.12363del, TP53_g.12363G>A, TP53_g.12363G>T, TP53_g.12363G>C, COSM21572, COSM6900, COSM22908, COSM45809, COSM45364, COSM1167885, COSM218537, COSM218536, COSM1167886, COSM3378369, COSM3388229, COSM2156353, COSM2744965, COSM218538, COSM1167887 19 FFPE GAGTA C/T TGTAG CMDL150079 FLD0203 FLD0227 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.994 0.995 1232 1711 pass pass 47570 48413 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150079 FLD0203 FLD0227 intron TP53 c.74+26G>A chr17 7579813 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579813", "IGV") medium 0.587 1232 pass no call 16708 TP53_E00001596491_1 ENSG00000141510 2 of 10 36 FFPE GTGGG C/T CTGCC CMDL150079 FLD0203 FLD0227 intron TP53 c.74+17G>A chr17 7579822 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579822", "IGV") medium 0.584 1232 pass no call 16341 TP53_E00001596491_1 ENSG00000141510 2 of 10 45 FFPE CCCTT C/T CAATG CMDL150079 FLD0203 FLD0227 synonymous TP53 c.15G>A c.15G>A(p.%3D) caG/caA chr17 7579898 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579898", "IGV") medium 0.260 1685 no call pass 5188 TP53_E00001596491_1 ENSG00000141510 2 of 11 TP53_g.11020G>T, COSM45588 25 FFPE TCTGA C/T TGCGG CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.371G>A p.C124Y tGc/tAc chr17 7579316 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579316", "IGV") low 0.147 3481 no call QD 1045 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11602G>C, TP53_g.11602G>A, COSM45006, COSM44885 tolerated(0.17) probably_damaging(0.98) 37 FFPE CCGTG C/T AAGTC CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.314G>A p.G105D gGc/gAc chr17 7579373 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579373", "IGV") medium 0.217 5505 pass no call 12676 TP53_E00001612188_1 ENSG00000141510 4 of 11 rs587781504, TP53_g.11545G>A, TP53_g.11545G>C, TP53_g.11545G>T, COSM45997, COSM46161, COSM562613, COSM562614, COSM1649366 deleterious(0) probably_damaging(1) 33 FFPE AGCTG C/T CCTGG CMDL150079 FLD0203 FLD0227 synonymous TP53 c.264C>T c.264C>T(p.%3D) gcC/gcT chr17 7579423 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579423", "IGV") low 0.158 2834 QD no call 2267 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11495C>T 46 FFPE GAGGG G/A GCTGG CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") medium 0.996 2834 pass no call 89862 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C,T =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") medium 0.396 2613 no call pass 63025 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C,T GGGGA CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.733G>A p.G245S Ggc/Agc chr17 7577548 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577548", "IGV") medium 0.527 3705 pass no call 41051 TP53_E00001665758_1 25032700, 25105660, 24853176 ENSG00000141510 7 of 11 CM010463, CM920674, rs28934575, CM900210, TP53_g.13370G>T, TP53_g.13370G>C, TP53_g.13370del, TP53_g.13370G>A, COSM6932, COSM11081, COSM10957, COSM44642, COSM121035, COSM562651, COSM1610835, COSM121036, COSM562652, COSM1610836, COSM3356965, COSM3388190, COSM3717640, COSM3717639, COSM1640833, COSM1646855, COSM121037, COSM562653, COSM1610837 deleterious(0) probably_damaging(1) likely_pathogenic,pathogenic 64 FFPE CATGC C/T GCCCA CMDL150079 FLD0203 FLD0227 synonymous TP53 c.723C>T c.723C>T(p.%3D) tcC/tcT chr17 7577558 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577558", "IGV") low 0.176 3705 QD no call 4862 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13360C>G, TP53_g.13360C>A, TP53_g.13360del, TP53_g.13360C>T, COSM6530, COSM44158, COSM43824, COSM46004, COSM437498, COSM437499, COSM3718845, COSM2744618, COSM437500 54 FFPE ATGCA G/A GAACT CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.722C>T p.S241F tCc/tTc chr17 7577559 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577559", "IGV") medium 0.244 5059 no call pass 37516 TP53_E00001665758_1 25105660, 21264207 ENSG00000141510 7 of 11 rs28934573, CM920673, TP53_g.13359C>A, TP53_g.13359del, TP53_g.13359C>T, TP53_g.13359C>G, COSM10709, COSM10812, COSM10935, COSM44657, COSM214171, COSM437501, COSM1230110, COSM1230111, COSM214170, COSM437502, COSM3712577, COSM3362448, COSM3522695, COSM2744620, COSM1649402, COSM2744619, COSM214172, COSM437503, COSM1230112 deleterious(0) probably_damaging(1) likely_pathogenic,pathogenic 53 FFPE TGCAG G/A AACTG CMDL150079 FLD0203 FLD0227 synonymous TP53 c.717C>T c.717C>T(p.%3D) aaC/aaT chr17 7577564 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577564", "IGV") medium 0.242 5059 no call pass 16355 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13354C>T, TP53_g.13354C>A, TP53_g.13354C>G, TP53_g.13354del, COSM44647, COSM44510, COSM45842 48 FFPE GAACT G/A TTACA CMDL150079 FLD0203 FLD0227 3_prime_UTR TP53 c.*41C>T chr17 7572886 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572886", "IGV") low 0.139 2384 no call QD 507 TP53_E00001757276_1 ENSG00000141510 11 of 11 17 FFPE AGATG G/A GGGTG CMDL150079 FLD0203 FLD0227 3_prime_UTR TP53 c.*34C>T chr17 7572893 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572893", "IGV") medium 0.273 2384 no call pass 8728 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs545818827 A:0.0002 24 FFPE GGTGG G/A AGGCT CMDL150079 FLD0203 FLD0227 stop_retained TP53 c.1181G>A c.1181G>A(p.%3D) tGa/tAa chr17 7572928 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7572928", "IGV") low 0.170 1835 QD no call 1042 TP53_E00001757276_1 ENSG00000141510 11 of 11 59 FFPE AATGT C/T AGTCT CMDL150079 FLD0203 FLD0227 synonymous TP53 c.1137C>T c.1137C>T(p.%3D) cgC/cgT chr17 7572972 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572972", "IGV") medium 0.262 2384 no call pass 19205 TP53_E00001757276_1 ENSG00000141510 11 of 11 COSM1386542, COSM1386543 39 FFPE TTATG G/A CGGGA CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.1121G>A p.G374D gGt/gAt chr17 7572988 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7572988", "IGV") medium 0.423 1835 pass no call 12998 TP53_E00001757276_1 ENSG00000141510 11 of 11 tolerated(0.13) benign(0.157) 23 FFPE ACTGA C/T CCTTT CMDL150079 FLD0203 FLD0227 synonymous TP53 c.1113C>T c.1113C>T(p.%3D) tcC/tcT chr17 7572996 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572996", "IGV") medium 0.257 2384 no call pass 19166 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs765530090 15 FFPE TTTTT G/A GACTT CMDL150079 FLD0203 FLD0227 intron TP53 c.993+40C>T chr17 7576813 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576813", "IGV") medium 0.185 2560 pass no call 11243 TP53_E00001789298_1 ENSG00000141510 9 of 10 7 FFPE AGACT G/A GAAAC CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.926C>T p.P309L cCc/cTc chr17 7576920 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576920", "IGV") low 0.185 5078 QD no call 5344 TP53_E00001789298_1 ENSG00000141510 9 of 11 TP53_g.13998C>T, TP53_g.13998C>G, TP53_g.13998C>A, COSM45616 tolerated(0.06) possibly_damaging(0.796) 44 FFPE TGTTG G/A GCAGT CMDL150079 FLD0203 FLD0227 synonymous TP53 c.909C>T c.909C>T(p.%3D) agC/agT chr17 7577029 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577029", "IGV") low 0.141 4807 QD no call 472 TP53_E00001789298_2 ENSG00000141510 8 of 11 TP53_g.13889C>T, COSM1386584, COSM1386585 27 FFPE TTAGT G/A CTCCC CMDL150079 FLD0203 FLD0227 synonymous TP53 c.909C>T c.909C>T(p.%3D) agC/agT chr17 7577029 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577029", "IGV") medium 0.213 1842 no call pass 10087 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13889C>T, COSM1386584, COSM1386585 7 FFPE TTAGT G/A CTCCC CMDL150079 FLD0203 FLD0227 synonymous TP53 c.882G>A c.882G>A(p.%3D) gaG/gaA chr17 7577056 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577056", "IGV") medium 0.221 3996 pass no call 8473 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13862G>T, TP53_g.13862G>A, COSM45534, COSM44412 34 FFPE TGAGG C/T TCCCC CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.878G>A p.G293E gGg/gAg chr17 7577060 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577060", "IGV") low 0.185 3638 no call QD 5862 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13858G>T, COSM46123 tolerated(1) benign(0.044) 38 FFPE GCTCC C/T CTTTC CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.859G>A p.E287K Gag/Aag chr17 7577079 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577079", "IGV") low 0.185 3638 no call QD 6044 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs587782006, CM044948, TP53_g.13839G>T, TP53_g.13839del, TP53_g.13839G>A, COSM44225, COSM44133, COSM214243, COSM1646819 deleterious(0.03) benign(0.211) uncertain_significance 57 FFPE ATTCT C/T TTCCT CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.799C>T p.R267W Cgg/Tgg chr17 7577139 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577139", "IGV") low 0.212 3638 no call QD 6473 TP53_E00001789298_3 25105660 ENSG00000141510 8 of 11 rs55832599, TP53_g.13779C>A, TP53_g.13779del, TP53_g.13779C>T, TP53_g.13779C>G, COSM11183, COSM45928, COSM45822, COSM179804, COSM3717629, COSM1640829 tolerated(0.05) possibly_damaging(0.728) likely_pathogenic 28 FFPE GTTCC G/A TCCCA CMDL150079 FLD0203 FLD0227 nonsynonymous TP53 c.796G>A p.G266R Gga/Aga chr17 7577142 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577142", "IGV") low 0.217 4012 QD no call 7509 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13776G>A, TP53_g.13776G>T, TP53_g.13776del, TP53_g.13776G>C, COSM44891, COSM10794, COSM11205, COSM45227, COSM1559475, COSM297539, COSM318165, COSM3388175, COSM1645293 deleterious(0.03) probably_damaging(0.999) 25 FFPE CCGTC C/T CAGTA CMDL150085 FLD0204 FLD0228 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.986 0.988 1533 1941 pass pass 63552 83018 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150085 FLD0204 FLD0228 synonymous EGFR c.2376C>T c.2376C>T(p.%3D) ctC/ctT chr7 55249078 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249078", "IGV") medium 0.217 1533 pass no call 8304 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM3833028 15 FFPE CAGCT C/T ATGCC CMDL150085 FLD0204 FLD0228 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.994 0.992 2331 2574 pass pass 105046 117382 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150085 FLD0204 FLD0228 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.997 0.997 2350 2576 pass pass 100385 109553 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150085 FLD0204 FLD0228 intron TP53 c.97-44G>A chr17 7579634 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579634", "IGV") low 0.166 1912 no call QD 2043 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs762445877 58 FFPE CTCAG C/T CCCCC CMDL150085 FLD0204 FLD0228 intron PTEN c.164+20C>T chr10 89653886 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653886", "IGV") low 0.142 4707 QD no call 317 PTEN_E00001156351_1 ENSG00000171862 2 of 8 11 FFPE ATTTT C/T TATTT CMDL150085 FLD0204 FLD0228 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.992 0.986 2965 3312 pass pass 91189 97560 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150085 FLD0204 FLD0228 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.995 0.989 3458 3763 pass pass 99752 109723 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150086 FLD0205 FLD0229 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.622 0.402 1953 1961 pass pass 44508 25952 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150086 FLD0205 FLD0229 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.563 0.485 2275 2497 pass pass 47131 42934 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150086 FLD0205 FLD0229 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.998 0.993 2579 2650 pass pass 110070 111781 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150086 FLD0205 FLD0229 nonsynonymous TP53 c.101C>T p.P34L cCc/cTc chr17 7579586 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579586", "IGV") low 0.138 5042 no call QD 1623 EXP0116_TP53_E4 ENSG00000141510 4 of 11 TP53_g.11332C>T, COSM43672 tolerated(0.23) benign(0.021) 21 FFPE GCAAG G/A GGGAC CMDL150086 FLD0205 FLD0229 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.993 0.995 3343 3370 pass pass 92799 95207 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150086 FLD0205 FLD0229 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.995 0.996 3724 3733 pass pass 123989 124753 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150086 FLD0205 FLD0229 stop_gained TP53 c.202G>T p.E68* Gag/Tag chr17 7579485 C A =hyperlink("http://localhost:60151/goto?locus=chr17:7579485", "IGV") high 0.675 0.674 3724 3733 pass pass 54699 55588 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11433del, TP53_g.11433G>T, TP53_g.11433G>C, COSM11513, COSM45213, COSM44917, COSM131521, COSM131522, COSM3378370, COSM1646879 16 FFPE AGCCT C/A TGGCA CMDL150094 FLD0206 FLD0230 nonsynonymous,splice_region BRAF c.1742A>G p.N581S aAt/aGt chr7 140453193 T C =hyperlink("http://localhost:60151/goto?locus=chr7:140453193", "IGV") medium 0.207 0.211 6861 6308 QD pass 12745 12644 BRAF_AA_HS ENSG00000157764 15 of 18 rs121913370, COSM1699452, COSM26460, COSM462 deleterious(0.04) benign(0.082) likely_pathogenic 41 FFPE ATATA T/C CTGAG CMDL150094 FLD0206 FLD0230 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") medium 0.935 659 no call pass 24478 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150094 FLD0206 FLD0230 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.237 0.515 2548 2520 pass pass 15130 49162 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150094 FLD0206 FLD0230 synonymous EGFR c.2376C>T c.2376C>T(p.%3D) ctC/ctT chr7 55249078 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249078", "IGV") low 0.157 4650 no call QD 3192 EGFR_E00001601336_2 ENSG00000146648 20 of 28 COSM3833028 57 FFPE CAGCT C/T ATGCC CMDL150094 FLD0206 FLD0230 nonsynonymous EGFR c.2407C>T p.R803W Cgg/Tgg chr7 55249109 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249109", "IGV") low 0.160 4872 QD no call 2712 EGFR_E00001601336_2 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(1) 86 FFPE ATGTC C/T GGGAA CMDL150094 FLD0206 FLD0230 synonymous EGFR c.2436G>A c.2436G>A(p.%3D) caG/caA chr7 55249138 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249138", "IGV") medium 0.310 4872 pass no call 19847 EGFR_E00001601336_2 ENSG00000146648 20 of 28 57 FFPE TCCCA G/A TACCT CMDL150094 FLD0206 FLD0230 nonsynonymous EGFR c.2453G>A p.C818Y tGt/tAt chr7 55249155 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249155", "IGV") medium 0.211 2276 no call pass 5403 EGFR_E00001601336_2 ENSG00000146648 20 of 28 COSM23611 deleterious(0) probably_damaging(1) 40 FFPE CTGGT G/A TGTGC CMDL150094 FLD0206 FLD0230 intron EGFR c.2626-12C>T chr7 55260447 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260447", "IGV") low 0.161 5724 QD no call 1680 EGFR_E00001631695_1 ENSG00000146648 21 of 27 rs775878427 60 FFPE TCTCT C/T ACCAT CMDL150094 FLD0206 FLD0230 nonsynonymous EGFR c.2675C>T p.T892I aCc/aTc chr7 55260508 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260508", "IGV") medium 0.156 0.393 5724 3925 QD pass 554 25459 EGFR_E00001631695_1 ENSG00000146648 22 of 28 rs151064287 deleterious(0.02) probably_damaging(1) 45 FFPE CTATA C/T CCACC CMDL150094 FLD0206 FLD0230 splice_region,intron EGFR c.2701+3G>A chr7 55260537 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260537", "IGV") medium 0.178 2831 pass no call 11022 EGFR_E00001631695_1 ENSG00000146648 22 of 27 16 FFPE ACGGT G/A AGTCA CMDL150094 FLD0206 FLD0230 intron EGFR c.2701+13C>T chr7 55260547 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260547", "IGV") medium 0.394 1935 no call pass 24772 EGFR_E00001631695_1 ENSG00000146648 22 of 27 6 FFPE ATAAT C/T CTGAT CMDL150094 FLD0206 FLD0230 intron EGFR c.2470-20C>T chr7 55259392 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259392", "IGV") low 0.115 3019 QD no call 3095 EGFR_E00001681524_1 ENSG00000146648 20 of 27 21 FFPE CACAG C/T AGGGT CMDL150094 FLD0206 FLD0230 splice_region,intron EGFR c.2470-3C>T chr7 55259409 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259409", "IGV") medium 0.125 5998 no call pass 13203 EGFR_E00001681524_1 ENSG00000146648 20 of 27 38 FFPE TGTTT C/T AGGGC CMDL150094 FLD0206 FLD0230 synonymous EGFR c.2481C>T c.2481C>T(p.%3D) taC/taT chr7 55259423 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259423", "IGV") low 0.123 5998 no call QD 430 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM53235, COSM1090890 52 FFPE AACTA C/T TTGGA CMDL150094 FLD0206 FLD0230 synonymous EGFR c.2478C>T c.2478C>T(p.%3D) aaC/aaT chr7 55259420 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259420", "IGV") low 0.083 2008 no call QD 666 EGFR_E00001681524_2 ENSG00000146648 21 of 28 4 FFPE ATGAA C/T TACTT CMDL150094 FLD0206 FLD0230 synonymous EGFR c.2484G>A c.2484G>A(p.%3D) ttG/ttA chr7 55259426 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259426", "IGV") medium 0.128 1856 pass no call 4348 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs727504312, COSM3639750 likely_benign 10 FFPE TACTT G/A GAGGA CMDL150094 FLD0206 FLD0230 synonymous EGFR c.2574G>A c.2574G>A(p.%3D) ctG/ctA chr7 55259516 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259516", "IGV") low 0.197 3694 QD no call 5611 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs397517129, COSM133590 uncertain_significance 56 FFPE GGGCT G/A GCCAA CMDL150094 FLD0206 FLD0230 nonsynonymous EGFR c.2612C>T p.A871V gCa/gTa chr7 55259554 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259554", "IGV") low 0.123 1962 no call QD 2946 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs397517134, COSM710350, COSM13008 deleterious(0.03) probably_damaging(0.959) uncertain_significance 18 FFPE CCATG C/T AGAAG CMDL150094 FLD0206 FLD0230 nonsynonymous EGFR c.2617G>A p.G873R Gga/Aga chr7 55259559 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259559", "IGV") low 0.085 1838 QD no call 254 EGFR_E00001681524_2 ENSG00000146648 21 of 28 deleterious(0) probably_damaging(0.997) 13 FFPE CAGAA G/A GAGGC CMDL150094 FLD0206 FLD0230 nonsynonymous EGFR c.3139G>A p.V1047M Gtg/Atg chr7 55269452 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269452", "IGV") medium 0.248 5017 no call pass 37130 EGFR_E00001773562_1 ENSG00000146648 26 of 28 rs142442994 tolerated(0.11) benign(0.026) 43 FFPE CCACC G/A TGGCT CMDL150094 FLD0206 FLD0230 nonsynonymous EGFR c.3142G>A p.A1048T Gct/Act chr7 55269455 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269455", "IGV") medium 0.248 5017 no call pass 37130 EGFR_E00001773562_1 ENSG00000146648 26 of 28 tolerated(0.6) benign(0.002) 40 FFPE CCGTG G/A CTTGC CMDL150094 FLD0206 FLD0230 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.675 0.431 2319 2294 pass pass 59808 33534 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150094 FLD0206 FLD0230 synonymous EGFR c.2811C>T c.2811C>T(p.%3D) ccC/ccT chr7 55266519 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266519", "IGV") low 0.149 6081 no call QD 2447 EGFR_E00001779947_2 ENSG00000146648 23 of 28 43 FFPE CCACC C/T ATATG CMDL150094 FLD0206 FLD0230 synonymous EGFR c.2838C>T c.2838C>T(p.%3D) atC/atT chr7 55266546 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266546", "IGV") low 0.159 6084 QD no call 2438 EGFR_E00001779947_2 ENSG00000146648 23 of 28 70 FFPE ATGAT C/T ATGGT CMDL150094 FLD0206 FLD0230 synonymous EGFR c.2940C>T c.2940C>T(p.%3D) gtC/gtT chr7 55268100 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268100", "IGV") low 0.098 1727 no call QD 766 EGFR_E00001790701_1 ENSG00000146648 24 of 28 14 FFPE CTTGT C/T ATTCA CMDL150094 FLD0206 FLD0230 synonymous EGFR c.2268C>T c.2268C>T(p.%3D) aaC/aaT chr7 55242498 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55242498", "IGV") low 0.171 6945 QD no call 5828 EGFR_Exon19 ENSG00000146648 19 of 28 20 FFPE GCCAA C/T AAGGA CMDL150094 FLD0206 FLD0230 intron TP53 c.96+27C>G chr17 7579673 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579673", "IGV") low 0.164 655 QD no call 839 EXP0116_TP53_E3 ENSG00000141510 3 of 10 62 FFPE CTCCA G/C GTCCC CMDL150094 FLD0206 FLD0230 synonymous TP53 c.129G>A c.129G>A(p.%3D) ttG/ttA chr17 7579558 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579558", "IGV") low 0.149 4238 QD no call 3852 EXP0116_TP53_E4 ENSG00000141510 4 of 11 rs754332870, TP53_g.11360del 49 FFPE AGCAT C/T AAATC CMDL150094 FLD0206 FLD0230 splice_region,synonymous KRAS c.111G>A c.111G>A(p.%3D) gaG/gaA chr12 25398208 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398208", "IGV") low 0.166 5278 QD no call 2383 KRAS_AA_HS ENSG00000133703 2 of 6 25 FFPE TTTAC C/T TCTAT CMDL150094 FLD0206 FLD0230 synonymous KRAS c.75G>A c.75G>A(p.%3D) caG/caA chr12 25398244 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398244", "IGV") low 0.159 5278 QD no call 2531 KRAS_AA_HS ENSG00000133703 2 of 6 CM116919 61 FFPE TGATT C/T TGAAT CMDL150094 FLD0206 FLD0230 nonsynonymous PIK3CA c.1621T>C p.S541P Tct/Cct chr3 178936079 T C =hyperlink("http://localhost:60151/goto?locus=chr3:178936079", "IGV") medium 0.474 325 pass no call 3005 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM249873 deleterious(0.03) probably_damaging(0.95) 48 FFPE CTCTC T/C CTGAA CMDL150094 FLD0206 FLD0230 3_prime_UTR PIK3CA c.*32G>A chr3 178952184 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178952184", "IGV") low 0.049 6077 QD no call 3997 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 24 FFPE ACTCT G/A GATTC CMDL150094 FLD0206 FLD0230 3_prime_UTR PIK3CA c.*45C>T chr3 178952197 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178952197", "IGV") low 0.102 3009 QD no call 2729 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 11 FFPE CACTG C/T ACTGT CMDL150094 FLD0206 FLD0230 3_prime_UTR PIK3CA c.*47C>T chr3 178952199 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178952199", "IGV") low 0.088 3009 QD no call 856 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 9 FFPE CTGCA C/T TGTTA CMDL150094 FLD0206 FLD0230 nonsynonymous PTEN c.970G>A p.D324N Gat/Aat chr10 89720819 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720819", "IGV") medium 0.421 6267 pass no call 57342 PTEN_E00001156315_7 ENSG00000171862 8 of 9 tolerated(0.13) benign(0.056) 77 FFPE AAAAT G/A ATCTT CMDL150094 FLD0206 FLD0230 nonsynonymous PTEN c.976G>A p.D326N Gac/Aac chr10 89720825 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720825", "IGV") medium 0.419 6267 pass no call 56775 PTEN_E00001156315_7 ENSG00000171862 8 of 9 CM071949, COSM1349619 deleterious(0) probably_damaging(0.995) 71 FFPE ATCTT G/A ACAAA CMDL150094 FLD0206 FLD0230 synonymous PTEN c.669G>A c.669G>A(p.%3D) aaG/aaA chr10 89717644 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717644", "IGV") low 0.155 5871 QD no call 1380 PTEN_E00001156321_1 ENSG00000171862 7 of 9 63 FFPE GTGAA G/A ATATA CMDL150094 FLD0206 FLD0230 nonsynonymous PTEN c.680C>T p.S227F tCc/tTc chr10 89717655 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717655", "IGV") medium 0.218 5269 no call pass 11080 PTEN_E00001156321_2 ENSG00000171862 7 of 9 COSM5095 deleterious(0.01) possibly_damaging(0.657) 16 FFPE TTCCT C/T CAATT CMDL150094 FLD0206 FLD0230 intron PTEN c.801+109G>A chr10 89717885 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717885", "IGV") medium 0.330 4487 no call pass 22232 PTEN_E00001156321_4m ENSG00000171862 7 of 8 49 FFPE GATCT G/A CAGGT CMDL150094 FLD0206 FLD0230 intron PTEN c.801+129G>A chr10 89717905 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717905", "IGV") medium 0.254 2229 pass no call 15727 PTEN_E00001156321_4m ENSG00000171862 7 of 8 29 FFPE ACTCT G/A GCATT CMDL150094 FLD0206 FLD0230 synonymous PTEN c.540C>T c.540C>T(p.%3D) taC/taT chr10 89711922 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711922", "IGV") low 0.081 2904 no call QD 150 PTEN_E00001156327_4 ENSG00000171862 6 of 9 CM074469, HM971505, COSM36367 14 FFPE AGCTA C/T CTGTT CMDL150094 FLD0206 FLD0230 synonymous PTEN c.321T>C c.321T>C(p.%3D) gaT/gaC chr10 89692837 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89692837", "IGV") low 0.173 5275 QD no call 3272 PTEN_E00001156330_1 ENSG00000171862 5 of 9 rs372876243, COSM1349505 likely_benign 62 FFPE GAAGA T/C CTTGA CMDL150094 FLD0206 FLD0230 nonsynonymous PTEN c.388C>G p.R130G Cga/Gga chr10 89692904 C G =hyperlink("http://localhost:60151/goto?locus=chr10:89692904", "IGV") high 0.541 0.536 2077 3110 pass pass 21769 33100 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CM971273, CM094223, rs121909224, COSM5329, COSM5219, COSM5152, COSM308347 deleterious(0) probably_damaging(0.999) pathogenic 41 FFPE AGGGA C/G GAACT CMDL150094 FLD0206 FLD0230 synonymous PTEN c.462C>T c.462C>T(p.%3D) ttC/ttT chr10 89692978 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692978", "IGV") low 0.149 3110 no call QD 411 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM13460, COSM5170 47 FFPE GATTT C/T TATGG CMDL150094 FLD0206 FLD0230 5_prime_UTR PTEN c.-10G>A chr10 89624217 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624217", "IGV") medium 0.157 2202 pass no call 4661 PTEN_E00001456562_1 ENSG00000171862 1 of 9 23 FFPE CACAG G/A CTCCC CMDL150094 FLD0206 FLD0230 intron TP53 c.993+238G>A chr17 7576615 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576615", "IGV") low 0.183 5647 QD no call 6433 TP53_00001404886_13 ENSG00000141510 9 of 10 8 FFPE ATTTT C/T ATGCT CMDL150094 FLD0206 FLD0230 intron TP53 c.993+161G>A chr17 7576692 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576692", "IGV") low 0.146 5647 QD no call 2253 TP53_00001404886_13 ENSG00000141510 9 of 10 23 FFPE GTGTT C/T TGAAG CMDL150094 FLD0206 FLD0230 synonymous TP53 c.651G>A c.651G>A(p.%3D) gtG/gtA chr17 7578198 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578198", "IGV") low 0.139 3141 no call QD 164 TP53_E00001255919_1 ENSG00000141510 6 of 11 TP53_g.12720G>A, TP53_g.12720G>C, COSM45922 55 FFPE GGCAC C/T ACCAC CMDL150094 FLD0206 FLD0230 synonymous TP53 c.585C>T c.585C>T(p.%3D) atC/atT chr17 7578264 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578264", "IGV") low 0.209 5158 QD no call 9983 TP53_E00001255919_3 ENSG00000141510 6 of 11 TP53_g.12654del, TP53_g.12654C>T, COSM562637, COSM562638, COSM562639, COSM562641, COSM1649392, COSM562640 15 FFPE ACTCG G/A ATAAG CMDL150094 FLD0206 FLD0230 nonsynonymous TP53 c.572C>T p.P191L cCt/cTt chr17 7578277 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578277", "IGV") low 0.173 6107 no call QD 5259 TP53_E00001255919_3 ENSG00000141510 6 of 11 rs587778718, CD972478, TP53_g.12641C>G, TP53_g.12641del, TP53_g.12641C>T, TP53_g.12641C>A, COSM44172, COSM44351, COSM45075, COSM3890517, COSM3890520, COSM3890522, COSM3890519, COSM3890518, COSM3890521 deleterious(0.01) probably_damaging(1) uncertain_significance,not_provided 28 FFPE GCTGA G/A GAGGG CMDL150094 FLD0206 FLD0230 intron TP53 c.559+32C>T chr17 7578339 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578339", "IGV") medium 0.268 5158 pass no call 18485 TP53_E00001255919_3 ENSG00000141510 5 of 10 rs748298015 51 FFPE AACCA G/A CCCTG CMDL150094 FLD0206 FLD0230 synonymous TP53 c.429G>A c.429G>A(p.%3D) gtG/gtA chr17 7578501 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578501", "IGV") low 0.186 3786 no call QD 5928 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12417G>C, TP53_g.12417del, TP53_g.12417G>A, TP53_g.12417G>T, COSM46087, COSM44902, COSM45780, COSM3958842, COSM3958845, COSM3958847, COSM3958844, COSM3958843, COSM3958846 57 FFPE AGCTG C/T ACAGG CMDL150094 FLD0206 FLD0230 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.636 0.471 2081 2593 pass pass 29534 22531 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150094 FLD0206 FLD0230 splice_region,intron TP53 c.74+8G>A chr17 7579831 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579831", "IGV") medium 0.266 2081 pass no call 9104 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs776933919 54 FFPE TGGAT C/T CACTC CMDL150094 FLD0206 FLD0230 stop_gained TP53 c.69G>A p.W23* tgG/tgA chr17 7579844 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579844", "IGV") medium 0.267 2081 pass no call 9180 TP53_E00001596491_1 ENSG00000141510 2 of 11 67 FFPE AGTTT C/T CATAG CMDL150094 FLD0206 FLD0230 intron TP53 c.375+17G>A chr17 7579295 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579295", "IGV") low 0.160 6298 QD no call 2829 TP53_E00001612188_1 ENSG00000141510 4 of 10 rs765179201, TP53_g.11623G>A, COSM44985 16 FFPE CCAGC C/T CCTCA CMDL150094 FLD0206 FLD0230 nonsynonymous TP53 c.305C>T p.T102I aCc/aTc chr17 7579382 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579382", "IGV") medium 0.251 5284 no call pass 18421 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11536C>T, COSM43678 deleterious(0.03) benign(0.081) 24 FFPE GGTAG G/A TTTTC CMDL150094 FLD0206 FLD0230 stop_gained TP53 c.298C>T p.Q100* Cag/Tag chr17 7579389 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579389", "IGV") medium 0.242 5284 no call pass 16392 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11529C>T, TP53_g.11529del, COSM44032, COSM1189391, COSM1189392 17 FFPE TTTCT G/A GGAAG CMDL150094 FLD0206 FLD0230 nonsynonymous TP53 c.238C>T p.P80S Cct/Tct chr17 7579449 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579449", "IGV") low 0.138 3105 no call QD 197 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11469C>T, TP53_g.11469del, COSM45219 tolerated(0.29) benign(0.081) 52 FFPE TGTAG G/A AGCTG CMDL150094 FLD0206 FLD0230 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.676 0.694 3283 3105 pass pass 49564 48777 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150094 FLD0206 FLD0230 nonsynonymous TP53 c.743G>A p.R248Q cGg/cAg chr17 7577538 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577538", "IGV") medium 0.260 4711 pass no call 13537 TP53_E00001665758_1 25032700, 20377871, 18798306, 15450681, 25105660, 21264207 ENSG00000141510 7 of 11 rs11540652, CM920675, TP53_g.13380G>A, TP53_g.13380G>C, TP53_g.13380G>T, TP53_g.13380del, COSM10662, COSM11491, COSM6549, COSM46135, COSM340105, COSM99602, COSM241995, COSM99020, COSM241994, COSM340106, COSM3356964, COSM3378346, COSM1640830, COSM1646857, COSM1646858, COSM99021, COSM241996, COSM340107 deleterious(0) probably_damaging(1) pathogenic 74 FFPE GCCTC C/T GGTTC CMDL150094 FLD0206 FLD0230 nonsynonymous TP53 c.677G>A p.G226D gGc/gAc chr17 7577604 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577604", "IGV") low 0.101 2309 QD no call 2172 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13314G>C, TP53_g.13314G>T, TP53_g.13314G>A, COSM44547, COSM45739, COSM44399 deleterious(0.02) benign(0.304) 8 FFPE CAGAG C/T CAACC CMDL150094 FLD0206 FLD0230 nonsynonymous TP53 c.1078G>A p.G360R Ggg/Agg chr17 7573949 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573949", "IGV") low 0.191 4421 QD no call 6564 TP53_E00001728015_1 ENSG00000141510 10 of 11 tolerated(0.53) benign(0.016) 69 FFPE CCCCC C/T TGGCT CMDL150094 FLD0206 FLD0230 nonsynonymous TP53 c.1066G>A p.G356R Ggg/Agg chr17 7573961 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573961", "IGV") low 0.126 4421 QD no call 630 TP53_E00001728015_1 ENSG00000141510 10 of 11 rs766786605, TP53_g.16957G>T, TP53_g.16957del, COSM44830, COSM45296 tolerated(0.47) benign(0.035) 76 FFPE CTTCC C/T AGCCT CMDL150094 FLD0206 FLD0230 synonymous TP53 c.1029G>A c.1029G>A(p.%3D) gaG/gaA chr17 7573998 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573998", "IGV") low 0.152 4352 no call QD 1071 TP53_E00001728015_1 ENSG00000141510 10 of 11 39 FFPE TTCAG C/T TCTCG CMDL150094 FLD0206 FLD0230 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.377 3776 no call pass 22295 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150094 FLD0206 FLD0230 nonsynonymous TP53 c.1133C>T p.S378F tCc/tTc chr17 7572976 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572976", "IGV") medium 0.334 3611 no call pass 17887 TP53_E00001757276_1 ENSG00000141510 11 of 11 deleterious(0.03) benign(0.078) 35 FFPE GGCGG G/A AGGTA CMDL150094 FLD0206 FLD0230 intron TP53 c.993+39C>T chr17 7576814 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576814", "IGV") medium 0.173 2331 pass no call 8821 TP53_E00001789298_1 ENSG00000141510 9 of 10 8 FFPE GACTG G/A AAACT CMDL150094 FLD0206 FLD0230 synonymous TP53 c.933C>T c.933C>T(p.%3D) aaC/aaT chr17 7576913 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576913", "IGV") low 0.173 4618 QD no call 3436 TP53_E00001789298_1 ENSG00000141510 9 of 11 rs201601993, TP53_g.14005C>G, TP53_g.14005del, COSM46472, COSM46396 51 FFPE CTGGT G/A TTGTT CMDL150094 FLD0206 FLD0230 intron TP53 c.920-16C>T chr17 7576942 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576942", "IGV") medium 0.154 2296 pass no call 6246 TP53_E00001789298_1 ENSG00000141510 8 of 10 22 FFPE GGCAA G/A GAAAG CMDL150094 FLD0206 FLD0230 synonymous TP53 c.906G>A c.906G>A(p.%3D) ggG/ggA chr17 7577032 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577032", "IGV") medium 0.188 1876 pass no call 8093 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13886del, TP53_g.13886G>T, TP53_g.13886G>C, COSM46318, COSM45998, COSM45177 10 FFPE GTGCT C/T CCTGG CMDL150094 FLD0206 FLD0230 nonsynonymous TP53 c.904G>A p.G302R Ggg/Agg chr17 7577034 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577034", "IGV") medium 0.196 1876 pass no call 6073 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13884G>A, TP53_g.13884del, COSM44237, COSM1386586, COSM1386587 tolerated(0.12) benign(0.033) 12 FFPE GCTCC C/T TGGGG CMDL150104 FLD0207 FLD0231 intron EGFR c.2284-63C>T chr7 55248923 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248923", "IGV") medium 0.274 317 no call pass 2694 EGFR_E00001601336_1 ENSG00000146648 19 of 27 3 FFPE GGGGT C/T CATGT CMDL150104 FLD0207 FLD0231 intron EGFR c.2284-60T>C chr7 55248926 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55248926", "IGV") medium 0.286 317 no call pass 3096 EGFR_E00001601336_1 18199332, 21869887 ENSG00000146648 19 of 27 rs10241451 C:0.1743 6 FFPE GTCCA T/C GTGCC CMDL150104 FLD0207 FLD0231 nonsynonymous EGFR c.2354C>T p.T785I aCc/aTc chr7 55249056 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249056", "IGV") medium 0.274 306 no call pass 2484 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM53288, COSM28930 deleterious(0) probably_damaging(1) 37 FFPE CTCCA C/T CGTGC CMDL150104 FLD0207 FLD0231 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.672 0.284 692 305 pass pass 17226 2686 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150104 FLD0207 FLD0231 nonsynonymous EGFR c.2374C>T p.L792F Ctc/Ttc chr7 55249076 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249076", "IGV") low 0.107 305 no call QD 259 EGFR_E00001601336_1 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(1) 17 FFPE CGCAG C/T TCATG CMDL150104 FLD0207 FLD0231 nonsynonymous EGFR c.2351C>T p.S784F tCc/tTc chr7 55249053 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249053", "IGV") medium 0.344 2308 no call pass 22377 EGFR_E00001601336_2 ENSG00000146648 20 of 28 COSM13189, COSM22950 deleterious(0) probably_damaging(1) 32 FFPE CACCT C/T CACCG CMDL150104 FLD0207 FLD0231 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") medium 0.158 2370 no call pass 6424 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150104 FLD0207 FLD0231 synonymous EGFR c.2409G>A c.2409G>A(p.%3D) cgG/cgA chr7 55249111 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249111", "IGV") medium 0.658 3798 pass no call 54036 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs397517123 likely_benign 84 FFPE GTCCG G/A GAACA CMDL150104 FLD0207 FLD0231 nonsynonymous EGFR c.2455G>A p.V819M Gtg/Atg chr7 55249157 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249157", "IGV") medium 0.428 2201 no call pass 33331 EGFR_E00001601336_2 ENSG00000146648 20 of 28 deleterious(0.02) probably_damaging(0.999) 38 FFPE GGTGT G/A TGCAG CMDL150104 FLD0207 FLD0231 splice_region,synonymous EGFR c.2469G>A c.2469G>A(p.%3D) aaG/aaA chr7 55249171 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249171", "IGV") medium 0.427 2195 no call pass 33092 EGFR_E00001601336_2 ENSG00000146648 20 of 28 24 FFPE GCAAA G/A GTAAT CMDL150104 FLD0207 FLD0231 intron EGFR c.2469+13G>A chr7 55249184 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249184", "IGV") medium 0.343 1825 pass no call 19430 EGFR_E00001601336_2 ENSG00000146648 20 of 27 rs764099332, COSM17569 11 FFPE GGGAA G/A GGAGA CMDL150104 FLD0207 FLD0231 intron EGFR c.2626-57T>C chr7 55260402 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55260402", "IGV") low 0.200 15 pass no call 44 EGFR_E00001631695_1 ENSG00000146648 21 of 27 15 FFPE AACTT T/C TTCCA CMDL150104 FLD0207 FLD0231 intron EGFR c.2626-34G>A chr7 55260425 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260425", "IGV") medium 0.490 1173 no call pass 20234 EGFR_E00001631695_1 ENSG00000146648 21 of 27 38 FFPE TAATA G/A TTGTC CMDL150104 FLD0207 FLD0231 nonsynonymous EGFR c.2650G>A p.E884K Gaa/Aaa chr7 55260483 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260483", "IGV") medium 0.495 2311 no call pass 22024 EGFR_E00001631695_1 ENSG00000146648 22 of 28 COSM1451612, COSM28575 deleterious(0) probably_damaging(1) 70 FFPE CATTG G/A AATCA CMDL150104 FLD0207 FLD0231 synonymous EGFR c.2481C>T c.2481C>T(p.%3D) taC/taT chr7 55259423 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259423", "IGV") low 0.117 953 no call QD 1467 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM53235, COSM1090890 7 FFPE AACTA C/T TTGGA CMDL150104 FLD0207 FLD0231 nonsynonymous EGFR c.3151G>A p.D1051N Gat/Aat chr7 55269464 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269464", "IGV") medium 0.553 4585 pass no call 50565 EGFR_E00001773562_1 ENSG00000146648 26 of 28 COSM3833029 tolerated(0.6) benign(0.002) 31 FFPE GCATT G/A ATAGA CMDL150104 FLD0207 FLD0231 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.996 0.998 1375 1315 pass pass 58113 55460 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150104 FLD0207 FLD0231 intron EGFR c.2849-27C>T chr7 55267982 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55267982", "IGV") medium 0.303 1375 no call pass 12740 EGFR_E00001790701_1 ENSG00000146648 23 of 27 rs745315446 24 FFPE AATTG C/T ACTGT CMDL150104 FLD0207 FLD0231 synonymous EGFR c.2883C>T c.2883C>T(p.%3D) ttC/ttT chr7 55268043 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268043", "IGV") medium 0.384 2739 no call pass 16988 EGFR_E00001790701_1 ENSG00000146648 24 of 28 71 FFPE AAGTT C/T CGTGA CMDL150104 FLD0207 FLD0231 synonymous EGFR c.2922C>T c.2922C>T(p.%3D) gaC/gaT chr7 55268082 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268082", "IGV") medium 0.390 1412 no call pass 17069 EGFR_E00001790701_1 ENSG00000146648 24 of 28 32 FFPE CGAGA C/T CCCCA CMDL150104 FLD0207 FLD0231 synonymous EGFR c.2937T>C c.2937T>C(p.%3D) ctT/ctC chr7 55268097 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55268097", "IGV") low 0.112 1276 QD no call 1499 EGFR_E00001790701_1 ENSG00000146648 24 of 28 17 FFPE TACCT T/C GTCAT CMDL150104 FLD0207 FLD0231 intron EGFR c.2947-19C>T chr7 55268862 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268862", "IGV") medium 0.370 5513 pass no call 32383 EGFR_E00001801208_1 ENSG00000146648 24 of 27 38 FFPE ATAGC C/T TCAAA CMDL150104 FLD0207 FLD0231 synonymous EGFR c.3051C>T c.3051C>T(p.%3D) ctC/ctT chr7 55268985 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268985", "IGV") medium 0.268 2310 no call pass 7587 EGFR_E00001801208_2 ENSG00000146648 25 of 28 rs780539015 47 FFPE TACCT C/T ATCCC CMDL150104 FLD0207 FLD0231 intron EGFR c.3114+12C>T chr7 55269060 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269060", "IGV") low 0.176 6093 QD no call 6010 EGFR_E00001801208_2 ENSG00000146648 25 of 27 rs199997298 T:0.0008 19 FFPE AATCT C/T TGTCT CMDL150104 FLD0207 FLD0231 nonsynonymous PTEN c.982G>A p.A328T Gca/Aca chr10 89720831 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720831", "IGV") medium 0.883 1072 no call pass 22993 PTEN_E00001156315_7 ENSG00000171862 8 of 9 deleterious(0) probably_damaging(0.992) 65 FFPE ACAAA G/A CAAAT CMDL150104 FLD0207 FLD0231 nonsynonymous PTEN c.717G>A p.M239I atG/atA chr10 89717692 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717692", "IGV") medium 0.425 4248 pass no call 31840 PTEN_E00001156321_1 ENSG00000171862 7 of 9 tolerated(0.75) benign(0.001) 15 FFPE TTCAT G/A TACTT CMDL150104 FLD0207 FLD0231 intron PTEN c.801+23G>A chr10 89717799 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717799", "IGV") low 0.750 4 no call pass 77 PTEN_E00001156321_4m ENSG00000171862 7 of 8 rs116160352 benign A:0.0008 30 FFPE ATTGG G/A AGAAA CMDL150104 FLD0207 FLD0231 intron PTEN c.801+50A>G chr10 89717826 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717826", "IGV") low 0.250 7 no call pass 41 PTEN_E00001156321_4m ENSG00000171862 7 of 8 57 FFPE AGATT A/G AAAGC CMDL150104 FLD0207 FLD0231 intron PTEN c.801+53A>T chr10 89717829 A T =hyperlink("http://localhost:60151/goto?locus=chr10:89717829", "IGV") low 0.250 7 no call pass 41 PTEN_E00001156321_4m ENSG00000171862 7 of 8 60 FFPE TTAAA A/T GCTAT CMDL150104 FLD0207 FLD0231 nonsynonymous PTEN c.517C>T p.R173C Cgc/Tgc chr10 89711899 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711899", "IGV") medium 0.283 1993 pass no call 6927 PTEN_E00001156327_1 ENSG00000171862 6 of 9 CM074467, rs121913293, COSM5089, COSM5825 deleterious(0.02) probably_damaging(0.913) pathogenic 19 FFPE AGAGG C/T GCTAT CMDL150104 FLD0207 FLD0231 nonsynonymous PTEN c.307C>T p.P103S Ccc/Tcc chr10 89692823 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692823", "IGV") medium 0.801 3998 pass no call 76482 PTEN_E00001156330_1 ENSG00000171862 5 of 9 COSM28939 deleterious(0.02) benign(0.098) 56 FFPE TCAAA C/T CCTTT CMDL150104 FLD0207 FLD0231 nonsynonymous PTEN c.361G>A p.A121T Gca/Aca chr10 89692877 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692877", "IGV") medium 0.468 988 pass no call 16219 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5214, COSM3724550 deleterious(0.02) probably_damaging(0.993) 14 FFPE TTGCA G/A CAATT CMDL150104 FLD0207 FLD0231 nonsynonymous PTEN c.451G>A p.A151T Gcc/Acc chr10 89692967 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692967", "IGV") medium 0.465 807 no call pass 7322 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5080 deleterious(0) probably_damaging(0.955) 58 FFPE AAGAG G/A CCCTA CMDL150104 FLD0207 FLD0231 synonymous PTEN c.468G>A c.468G>A(p.%3D) ggG/ggA chr10 89692984 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692984", "IGV") medium 0.320 807 no call pass 4523 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM1349549 41 FFPE TATGG G/A GAAGT CMDL150104 FLD0207 FLD0231 intron PTEN c.165-31G>A chr10 89685239 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89685239", "IGV") low 0.875 16 pass no call 257 PTEN_E00001156344_1 ENSG00000171862 2 of 8 rs747222769 40 FFPE TAATG G/A TGGCT CMDL150104 FLD0207 FLD0231 nonsynonymous PTEN c.1097C>T p.T366I aCa/aTa chr10 89725114 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725114", "IGV") medium 0.238 627 pass no call 3667 PTEN_E00001456541_2 ENSG00000171862 9 of 9 tolerated(0.07) benign(0.221) 26 FFPE TGTAA C/T ACCAG CMDL150104 FLD0207 FLD0231 nonsynonymous PTEN c.1154C>T p.S385F tCt/tTt chr10 89725171 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725171", "IGV") medium 0.390 3612 no call pass 23326 PTEN_E00001456541_2 ENSG00000171862 9 of 9 deleterious_low_confidence(0) probably_damaging(0.998) 70 FFPE TGACT C/T TGATC CMDL150104 FLD0207 FLD0231 nonsynonymous PTEN c.1207G>A p.V403I Gtc/Atc chr10 89725224 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725224", "IGV") medium 0.383 542 pass no call 6732 PTEN_E00001456541_2 ENSG00000171862 9 of 9 deleterious_low_confidence(0.02) benign(0.197) 17 FFPE CAAAA G/A TCTGA CMDL150104 FLD0207 FLD0231 5_prime_UTR PTEN c.-22C>T chr10 89624205 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624205", "IGV") low 0.534 89 pass no call 1076 PTEN_E00001456562_1 ENSG00000171862 1 of 9 COSM5899 11 FFPE TTTTT C/T TTCAG CMDL150104 FLD0207 FLD0231 splice_region,intron PTEN c.79+6C>T chr10 89624311 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624311", "IGV") medium 0.531 179 pass no call 1843 PTEN_E00001456562_1 ENSG00000171862 1 of 8 42 FFPE GTATC C/T ATTTC CMDL150104 FLD0207 FLD0231 intron TP53 c.560-16C>T chr17 7578305 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578305", "IGV") low 0.203 3944 QD no call 6149 TP53_E00001255919_3 ENSG00000141510 5 of 10 56 FFPE TCAGT G/A AGGAA CMDL150104 FLD0207 FLD0231 intron TP53 c.559+39C>T chr17 7578332 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578332", "IGV") low 0.200 3944 QD no call 6372 TP53_E00001255919_3 ENSG00000141510 5 of 10 58 FFPE CCTGG G/A CAACC CMDL150104 FLD0207 FLD0231 nonsynonymous,splice_region TP53 c.559G>A p.G187S Ggt/Agt chr17 7578371 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578371", "IGV") medium 0.212 2056 no call pass 4201 TP53_E00001255919_3 ENSG00000141510 5 of 11 rs776167460, TP53_g.12547G>C, TP53_g.12547G>A, TP53_g.12547del, TP53_g.12547G>T, COSM44026, COSM45275, COSM2744801, COSM45147, COSM437537, COSM2744802, COSM2744804, COSM437538, COSM2744806, COSM437540, COSM3522697, COSM3958827, COSM1636742, COSM2744803, COSM437539, COSM2744805 tolerated(0.21) possibly_damaging(0.528) 19 FFPE CTCAC C/T ATCGC CMDL150104 FLD0207 FLD0231 synonymous TP53 c.528C>T c.528C>T(p.%3D) tgC/tgT chr17 7578402 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578402", "IGV") medium 0.538 1040 pass no call 11196 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12516C>G, TP53_g.12516C>A, TP53_g.12516del, TP53_g.12516C>T, COSM44134, COSM11114, COSM43734, COSM179823, COSM1268357, COSM179822, COSM1268358, COSM179824, COSM1268360, COSM179825, COSM1268359 24 FFPE TGGGG G/A CAGCG CMDL150104 FLD0207 FLD0231 synonymous TP53 c.420C>T c.420C>T(p.%3D) acC/acT chr17 7578510 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578510", "IGV") low 0.201 4975 no call QD 7016 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12408C>A, TP53_g.12408C>T, COSM69019, COSM44706 64 FFPE GGGCA G/A GTCTT CMDL150104 FLD0207 FLD0231 intron TP53 c.74+47C>T chr17 7579792 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579792", "IGV") medium 0.260 2048 no call pass 6684 TP53_E00001596491_1 ENSG00000141510 2 of 10 15 FFPE GCTGG G/A GTTGG CMDL150104 FLD0207 FLD0231 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.998 0.993 485 2048 pass pass 12883 64111 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150104 FLD0207 FLD0231 5_prime_UTR TP53 c.-5C>T chr17 7579917 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579917", "IGV") medium 0.239 1031 no call pass 6616 TP53_E00001596491_1 ENSG00000141510 2 of 11 6 FFPE TGGCA G/A TGACC CMDL150104 FLD0207 FLD0231 intron TP53 c.375+11C>T chr17 7579301 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579301", "IGV") medium 0.211 5059 no call pass 10250 TP53_E00001612188_1 ENSG00000141510 4 of 10 22 FFPE CCTCA G/A GGCAA CMDL150104 FLD0207 FLD0231 nonsynonymous,splice_region TP53 c.374C>T p.T125M aCg/aTg chr17 7579313 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579313", "IGV") medium 0.317 5059 no call pass 23918 TP53_E00001612188_1 ENSG00000141510 4 of 11 CM102351, TP53_g.11605C>T, TP53_g.11605C>A, TP53_g.11605C>G, COSM44988, COSM44073, COSM45243, COSM168303, COSM326726, COSM168302, COSM326725, COSM3717682, COSM1750374 deleterious(0.03) probably_damaging(0.996) 34 FFPE TGACC G/A TGCAA CMDL150104 FLD0207 FLD0231 nonsynonymous TP53 c.254C>T p.P85L cCt/cTt chr17 7579433 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579433", "IGV") medium 0.721 2783 no call pass 43499 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11485C>T, COSM1386905, COSM45837, COSM1386906, COSM1386907 tolerated(0.42) benign(0.011) 56 FFPE GTGCA G/A GGGCC CMDL150104 FLD0207 FLD0231 nonsynonymous TP53 c.229C>T p.P77S Cca/Tca chr17 7579458 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579458", "IGV") medium 0.363 2903 pass no call 16901 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs753085009, TP53_g.11460C>G, TP53_g.11460del, COSM44287, COSM46118 tolerated(0.45) benign(0.017) 43 FFPE TGCTG G/A TGCAG CMDL150104 FLD0207 FLD0231 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.994 0.997 2903 2783 pass pass 98208 94312 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150104 FLD0207 FLD0231 nonsynonymous TP53 c.758C>T p.T253I aCc/aTc chr17 7577523 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577523", "IGV") medium 0.365 5143 no call pass 28393 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13395C>G, TP53_g.13395C>T, TP53_g.13395C>A, COSM44993, COSM43683, COSM4070036, COSM307262, COSM307261, COSM4070039, COSM4070038, COSM4070037 deleterious(0) probably_damaging(1) 74 FFPE TGATG G/A TGAGG CMDL150104 FLD0207 FLD0231 nonsynonymous TP53 c.1088G>A p.R363K aGg/aAg chr17 7573939 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573939", "IGV") medium 0.710 2998 no call pass 47822 TP53_E00001728015_1 ENSG00000141510 10 of 11 TP53_g.16979G>A tolerated(0.4) benign(0.008) 59 FFPE GAGCC C/T TGCTC CMDL150104 FLD0207 FLD0231 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.597 2396 pass no call 30295 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150104 FLD0207 FLD0231 nonsynonymous TP53 c.1160C>T p.T387I aCa/aTa chr17 7572949 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572949", "IGV") medium 0.768 1846 no call pass 30856 TP53_E00001757276_1 ENSG00000141510 11 of 11 tolerated(0.07) benign(0.081) 62 FFPE CTTCT G/A TCTTG CMDL150104 FLD0207 FLD0231 synonymous TP53 c.1149C>T c.1149C>T(p.%3D) ctC/ctT chr17 7572960 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572960", "IGV") medium 0.767 1846 no call pass 52240 TP53_E00001757276_1 ENSG00000141510 11 of 11 51 FFPE AACAT G/A AGTTT CMDL150104 FLD0207 FLD0231 synonymous TP53 c.1134C>T c.1134C>T(p.%3D) tcC/tcT chr17 7572975 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572975", "IGV") medium 0.765 1846 no call pass 30361 TP53_E00001757276_1 ENSG00000141510 11 of 11 36 FFPE TGGCG G/A GAGGT CMDL150104 FLD0207 FLD0231 synonymous TP53 c.969G>A c.969G>A(p.%3D) ctG/ctA chr17 7576877 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576877", "IGV") medium 0.280 3180 pass no call 11548 TP53_E00001789298_1 ENSG00000141510 9 of 11 rs672601297 not_provided 71 FFPE CCATC C/T AGTGG CMDL150104 FLD0207 FLD0231 intron TP53 c.919+18G>A chr17 7577001 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577001", "IGV") medium 0.236 4805 no call pass 9623 TP53_E00001789298_2 ENSG00000141510 8 of 10 TP53_g.13917G>C, COSM46293 55 FFPE CGCTT C/T TTGTC CMDL150104 FLD0207 FLD0231 intron TP53 c.919+12G>A chr17 7577007 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577007", "IGV") medium 0.274 5632 pass no call 18483 TP53_E00001789298_2 ENSG00000141510 8 of 10 TP53_g.13911G>A 49 FFPE TTGTC C/T TGCTT CMDL150111 FLD0208 FLD0232 intron BRAF c.1742-21C>T chr7 140453214 G A =hyperlink("http://localhost:60151/goto?locus=chr7:140453214", "IGV") low 0.135 6488 no call QD 1506 BRAF_AA_HS ENSG00000157764 14 of 17 20 FFPE TAAAG G/A AAAAC CMDL150111 FLD0208 FLD0232 intron EGFR c.2284-62C>T chr7 55248924 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248924", "IGV") medium 0.190 926 no call pass 4388 EGFR_E00001601336_1 ENSG00000146648 19 of 27 4 FFPE GGGTC C/T ATGTG CMDL150111 FLD0208 FLD0232 intron EGFR c.2284-54C>T chr7 55248932 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248932", "IGV") medium 0.779 1266 pass no call 38336 EGFR_E00001601336_1 ENSG00000146648 19 of 27 12 FFPE GTGCC C/T CTCCT CMDL150111 FLD0208 FLD0232 nonsynonymous EGFR c.2288C>T p.A763V gCc/gTc chr7 55248990 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248990", "IGV") low 0.168 2482 QD no call 2131 EGFR_E00001601336_1 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(1) 70 FFPE GGAAG C/T CTACG CMDL150111 FLD0208 FLD0232 synonymous EGFR c.2346C>T c.2346C>T(p.%3D) ctC/ctT chr7 55249048 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249048", "IGV") medium 0.780 2482 pass no call 46220 EGFR_E00001601336_1 ENSG00000146648 20 of 28 45 FFPE TGCCT C/T ACCTC CMDL150111 FLD0208 FLD0232 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.946 0.903 1216 896 pass pass 46992 31466 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150111 FLD0208 FLD0232 synonymous EGFR c.2329C>T c.2329C>T(p.%3D) Ctg/Ttg chr7 55249031 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249031", "IGV") low 0.121 2270 QD no call 4486 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs397517117 likely_benign 10 FFPE GCCGC C/T TGCTG CMDL150111 FLD0208 FLD0232 synonymous EGFR c.2349C>T c.2349C>T(p.%3D) acC/acT chr7 55249051 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249051", "IGV") low 0.120 2270 QD no call 4464 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs397517122 likely_benign 30 FFPE CTCAC C/T TCCAC CMDL150111 FLD0208 FLD0232 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") medium 0.305 2801 no call pass 25728 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150111 FLD0208 FLD0232 synonymous EGFR c.2409G>A c.2409G>A(p.%3D) cgG/cgA chr7 55249111 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249111", "IGV") medium 0.246 4454 pass no call 11137 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs397517123 likely_benign 84 FFPE GTCCG G/A GAACA CMDL150111 FLD0208 FLD0232 intron EGFR c.2626-42A>G chr7 55260417 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55260417", "IGV") low 0.105 2174 QD no call 1645 EGFR_E00001631695_1 ENSG00000146648 21 of 27 30 FFPE AGGGA A/G ACTAA CMDL150111 FLD0208 FLD0232 stop_gained EGFR c.2639G>A p.W880* tGg/tAg chr7 55260472 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260472", "IGV") medium 0.278 4378 pass no call 14255 EGFR_E00001631695_1 ENSG00000146648 22 of 28 81 FFPE CAAGT G/A GATGG CMDL150111 FLD0208 FLD0232 intron EGFR c.2470-31G>A chr7 55259381 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259381", "IGV") low 0.120 2946 no call QD 4748 EGFR_E00001681524_1 ENSG00000146648 20 of 27 10 FFPE GATCT G/A TCCCT CMDL150111 FLD0208 FLD0232 intron EGFR c.2470-29C>T chr7 55259383 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259383", "IGV") low 0.089 2946 no call QD 866 EGFR_E00001681524_1 ENSG00000146648 20 of 27 12 FFPE TCTGT C/T CCTCA CMDL150111 FLD0208 FLD0232 nonsynonymous EGFR c.2527G>A p.V843I Gta/Ata chr7 55259469 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259469", "IGV") low 0.167 5895 no call QD 3033 EGFR_E00001681524_1 ENSG00000146648 21 of 28 CM082606, rs146795390, COSM85894, COSM3412202, COSM747424 deleterious(0.04) possibly_damaging(0.843) 57 FFPE GGAAC G/A TACTG CMDL150111 FLD0208 FLD0232 synonymous EGFR c.2577C>T c.2577C>T(p.%3D) gcC/gcT chr7 55259519 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259519", "IGV") low 0.128 2472 QD no call 1285 EGFR_E00001681524_1 ENSG00000146648 21 of 28 7 FFPE CTGGC C/T AAACT CMDL150111 FLD0208 FLD0232 intron EGFR c.3115-23C>T chr7 55269405 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269405", "IGV") low 0.155 5672 no call QD 1390 EGFR_E00001773562_1 ENSG00000146648 25 of 27 51 FFPE ATGGG C/T AACTT CMDL150111 FLD0208 FLD0232 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.996 0.998 1573 2175 pass pass 66587 93917 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150111 FLD0208 FLD0232 synonymous EGFR c.2727C>T c.2727C>T(p.%3D) acC/acT chr7 55266435 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266435", "IGV") medium 0.314 4365 no call pass 19007 EGFR_E00001779947_1 ENSG00000146648 23 of 28 rs747305344 52 FFPE ATGAC C/T TTTGG CMDL150111 FLD0208 FLD0232 nonsynonymous EGFR c.2864C>T p.A955V gCa/gTa chr7 55268024 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268024", "IGV") low 0.153 4152 QD no call 367 EGFR_E00001790701_1 ENSG00000146648 24 of 28 deleterious(0.02) probably_damaging(1) 66 FFPE AGACG C/T AGATA CMDL150111 FLD0208 FLD0232 synonymous EGFR c.2925C>T c.2925C>T(p.%3D) ccC/ccT chr7 55268085 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268085", "IGV") low 0.073 2581 no call QD 357 EGFR_E00001790701_1 ENSG00000146648 24 of 28 rs778672343 29 FFPE GACCC C/T CAGCG CMDL150111 FLD0208 FLD0232 synonymous EGFR c.2940C>T c.2940C>T(p.%3D) gtC/gtT chr7 55268100 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268100", "IGV") low 0.103 2058 QD no call 1456 EGFR_E00001790701_1 ENSG00000146648 24 of 28 14 FFPE CTTGT C/T ATTCA CMDL150111 FLD0208 FLD0232 intron EGFR c.2947-44C>T chr7 55268837 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268837", "IGV") medium 0.186 2718 pass no call 9294 EGFR_E00001801208_1 ENSG00000146648 24 of 27 13 FFPE AATAG C/T ATCTC CMDL150111 FLD0208 FLD0232 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.707 0.728 5323 6498 pass pass 87169 123595 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150111 FLD0208 FLD0232 splice_acceptor EGFR c.2185-1G>A chr7 55242414 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55242414", "IGV") low 0.086 6033 QD no call 3063 EGFR_Exon19 ENSG00000146648 18 of 27 20 FFPE TCATA G/A GGACT CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.79C>T p.P27S Cct/Tct chr17 7579717 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579717", "IGV") low 0.149 523 QD no call 458 EXP0116_TP53_E3 ENSG00000141510 3 of 11 TP53_g.11201del, COSM44957, COSM1167900, COSM1167901, COSM1167902, COSM3522717, COSM3522716, COSM1167903 tolerated(0.08) benign(0.219) 18 FFPE TTCAG G/A AAGTC CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.145G>A p.D49N Gat/Aat chr17 7579542 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579542", "IGV") medium 0.223 4588 pass no call 10114 EXP0116_TP53_E4 ENSG00000141510 4 of 11 rs587780728, TP53_g.11376G>T, TP53_g.11376G>A, TP53_g.11376G>C, COSM11935, COSM305601, COSM46172, COSM305603, COSM305602 tolerated(0.32) benign(0.008) uncertain_significance,likely_benign 46 FFPE AATAT C/T GTCCG CMDL150111 FLD0208 FLD0232 synonymous TP53 c.138C>G c.138C>G(p.%3D) tcC/tcG chr17 7579549 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579549", "IGV") low 0.129 4293 no call QD 1716 EXP0116_TP53_E4 ENSG00000141510 4 of 11 TP53_g.11369C>T 53 FFPE TCCGG G/C GACAG CMDL150111 FLD0208 FLD0232 nonsynonymous PIK3CA c.1552G>A p.A518T Gct/Act chr3 178936010 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936010", "IGV") medium 0.393 914 pass no call 5983 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 tolerated(0.26) benign(0.021) 46 FFPE GACTA G/A CTAGA CMDL150111 FLD0208 FLD0232 nonsynonymous PIK3CA c.1612G>A p.D538N Gat/Aat chr3 178936070 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936070", "IGV") medium 0.390 914 pass no call 6019 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM21467, COSM1716811, COSM729821 deleterious(0) probably_damaging(1) 57 FFPE CACGA G/A ATCCT CMDL150111 FLD0208 FLD0232 nonsynonymous,splice_region PTEN c.802G>A p.D268N Gac/Aac chr10 89720651 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720651", "IGV") medium 0.439 123 pass no call 2030 PTEN_E00001156315_1m ENSG00000171862 8 of 9 deleterious(0) benign(0.026) 34 FFPE TTTAG G/A ACAAA CMDL150111 FLD0208 FLD0232 splice_region,intron PTEN c.1026+4A>G chr10 89720879 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89720879", "IGV") medium 0.144 3261 no call pass 7778 PTEN_E00001156315_7 ENSG00000171862 8 of 8 17 FFPE AGGTC A/G GTTAA CMDL150111 FLD0208 FLD0232 intron PTEN c.635-21G>A chr10 89717589 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717589", "IGV") medium 0.304 4719 pass no call 19732 PTEN_E00001156321_1 ENSG00000171862 6 of 8 19 FFPE ATACT G/A GTATG CMDL150111 FLD0208 FLD0232 synonymous PTEN c.702G>A c.702G>A(p.%3D) cgG/cgA chr10 89717677 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717677", "IGV") medium 0.167 4833 no call pass 20143 PTEN_E00001156321_1 ENSG00000171862 7 of 9 30 FFPE CGACG G/A GAAGA CMDL150111 FLD0208 FLD0232 synonymous PTEN c.711G>A c.711G>A(p.%3D) aaG/aaA chr10 89717686 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717686", "IGV") medium 0.168 4833 no call pass 20143 PTEN_E00001156321_1 ENSG00000171862 7 of 9 rs773353820, COSM5806 21 FFPE GACAA G/A TTCAT CMDL150111 FLD0208 FLD0232 nonsynonymous PTEN c.717G>A p.M239I atG/atA chr10 89717692 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717692", "IGV") low 0.147 4713 QD no call 1374 PTEN_E00001156321_1 ENSG00000171862 7 of 9 tolerated(0.75) benign(0.001) 15 FFPE TTCAT G/A TACTT CMDL150111 FLD0208 FLD0232 nonsynonymous PTEN c.677C>T p.S226F tCc/tTc chr10 89717652 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717652", "IGV") medium 0.377 2281 pass no call 26896 PTEN_E00001156321_2 ENSG00000171862 7 of 9 COSM1702738 deleterious(0.05) benign(0.039) 13 FFPE ATATT C/T CTCCA CMDL150111 FLD0208 FLD0232 nonsynonymous PTEN c.792G>A p.M264I atG/atA chr10 89717767 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717767", "IGV") low 0.203 5600 no call QD 9894 PTEN_E00001156321_2 ENSG00000171862 7 of 9 tolerated(0.11) benign(0.007) 9 FFPE AAGAT G/A CTAAA CMDL150111 FLD0208 FLD0232 intron PTEN c.801+13C>T chr10 89717789 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717789", "IGV") medium 0.303 1967 pass no call 18356 PTEN_E00001156321_4m ENSG00000171862 7 of 8 20 FFPE CTTTA C/T TTTCA CMDL150111 FLD0208 FLD0232 intron PTEN c.801+21G>A chr10 89717797 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717797", "IGV") medium 0.149 1583 no call pass 4625 PTEN_E00001156321_4m ENSG00000171862 7 of 8 28 FFPE TCATT G/A GGAGA CMDL150111 FLD0208 FLD0232 intron PTEN c.801+84C>T chr10 89717860 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717860", "IGV") medium 0.304 3921 pass no call 15550 PTEN_E00001156321_4m ENSG00000171862 7 of 8 74 FFPE AGGAA C/T TATAA CMDL150111 FLD0208 FLD0232 intron PTEN c.801+112G>A chr10 89717888 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717888", "IGV") low 0.186 3921 QD no call 3908 PTEN_E00001156321_4m ENSG00000171862 7 of 8 46 FFPE CTGCA G/A GTGTT CMDL150111 FLD0208 FLD0232 intron PTEN c.634+22C>T chr10 89712038 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89712038", "IGV") medium 0.292 4624 pass no call 18858 PTEN_E00001156327_4 ENSG00000171862 6 of 8 12 FFPE CTCAT C/T CTTCC CMDL150111 FLD0208 FLD0232 splice_acceptor PTEN c.254-1G>A chr10 89692769 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692769", "IGV") low 0.110 2719 no call QD 1369 PTEN_E00001156330_1 ENSG00000171862 4 of 8 2 FFPE CCACA G/A TTGCA CMDL150111 FLD0208 FLD0232 nonsynonymous PTEN c.427G>A p.G143S Ggc/Agc chr10 89692943 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692943", "IGV") low 0.138 2949 no call QD 446 PTEN_E00001156330_3 ENSG00000171862 5 of 9 tolerated(0.21) benign(0.072) 80 FFPE ATCGG G/A GCAAA CMDL150111 FLD0208 FLD0232 synonymous PTEN c.171G>A c.171G>A(p.%3D) ttG/ttA chr10 89685276 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89685276", "IGV") medium 0.348 1802 pass no call 21965 PTEN_E00001156344_1 ENSG00000171862 3 of 9 63 FFPE TTTTT G/A GATTC CMDL150111 FLD0208 FLD0232 synonymous PTEN c.180G>A c.180G>A(p.%3D) aaG/aaA chr10 89685285 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89685285", "IGV") medium 0.345 1802 pass no call 12295 PTEN_E00001156344_1 ENSG00000171862 3 of 9 CD031878 54 FFPE TCAAA G/A CATAA CMDL150111 FLD0208 FLD0232 nonsynonymous PTEN c.1091C>T p.S364F tCt/tTt chr10 89725108 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725108", "IGV") medium 0.292 6271 no call pass 24344 PTEN_E00001456541_1 ENSG00000171862 9 of 9 COSM23645 tolerated(0.05) possibly_damaging(0.736) 53 FFPE AACTT C/T TGTAA CMDL150111 FLD0208 FLD0232 nonsynonymous PTEN c.7G>A p.A3T Gcc/Acc chr10 89624233 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624233", "IGV") low 0.205 3815 no call QD 6342 PTEN_E00001456562_1 ENSG00000171862 1 of 9 COSM5207 tolerated(1) benign(0.004) 39 FFPE TGACA G/A CCATC CMDL150111 FLD0208 FLD0232 synonymous PTEN c.30C>T c.30C>T(p.%3D) agC/agT chr10 89624256 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624256", "IGV") medium 0.222 3815 no call pass 8506 PTEN_E00001456562_1 ENSG00000171862 1 of 9 COSM1349463, COSM3967199 62 FFPE GTTAG C/T AGAAA CMDL150111 FLD0208 FLD0232 synonymous PTEN c.72C>T c.72C>T(p.%3D) gaC/gaT chr10 89624298 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624298", "IGV") low 0.152 3815 no call QD 1051 PTEN_E00001456562_1 ENSG00000171862 1 of 9 COSM5198 55 FFPE TTAGA C/T TTGAC CMDL150111 FLD0208 FLD0232 intron TP53 c.993+198C>T chr17 7576655 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576655", "IGV") low 0.218 4662 QD no call 8660 TP53_00001404886_13 ENSG00000141510 9 of 10 rs750031971 48 FFPE GTCTG G/A TCCTT CMDL150111 FLD0208 FLD0232 intron TP53 c.993+170C>T chr17 7576683 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576683", "IGV") medium 0.265 4662 pass no call 14644 TP53_00001404886_13 ENSG00000141510 9 of 10 32 FFPE TATAA G/A TTGGT CMDL150111 FLD0208 FLD0232 intron TP53 c.993+147G>A chr17 7576706 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576706", "IGV") low 0.163 4815 no call QD 4243 TP53_00001404886_13 ENSG00000141510 9 of 10 9 FFPE GTTAG C/T TACAA CMDL150111 FLD0208 FLD0232 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.998 1667 pass no call 26526 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150111 FLD0208 FLD0232 intron TP53 c.672+48G>A chr17 7578129 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578129", "IGV") low 0.001 3461 FS no call 17380 TP53_E00001255919_1 24868540 ENSG00000141510 6 of 10 rs17884607 T:0.0034 20 FFPE ACTGA C/T AACCA CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.626G>A p.R209K aGa/aAa chr17 7578223 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578223", "IGV") medium 0.309 3543 pass no call 15282 TP53_E00001255919_1 ENSG00000141510 6 of 11 TP53_g.12695G>T, TP53_g.12695G>C, TP53_g.12695del, TP53_g.12695G>A, COSM45438, COSM45257, COSM46120, COSM45995, COSM308315, COSM984931, COSM308314, COSM984933, COSM308316, COSM984935, COSM308317, COSM984934 tolerated(0.91) benign(0.003) 30 FFPE TGTTT C/T TGTCA CMDL150111 FLD0208 FLD0232 intron TP53 c.560-39G>A chr17 7578328 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578328", "IGV") low 0.145 4875 QD no call 3306 TP53_E00001255919_3 ENSG00000141510 5 of 10 rs765032410 62 FFPE GGACC C/T TGGGC CMDL150111 FLD0208 FLD0232 intron TP53 c.559+40C>T chr17 7578331 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578331", "IGV") low 0.145 4528 no call QD 955 TP53_E00001255919_3 ENSG00000141510 5 of 10 59 FFPE CCCTG G/A GCAAC CMDL150111 FLD0208 FLD0232 intron TP53 c.559+35G>A chr17 7578336 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578336", "IGV") medium 0.148 4875 pass no call 14296 TP53_E00001255919_3 ENSG00000141510 5 of 10 54 FFPE GGCAA C/T CAGCC CMDL150111 FLD0208 FLD0232 synonymous TP53 c.492G>A c.492G>A(p.%3D) aaG/aaA chr17 7578438 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578438", "IGV") low 0.154 3754 QD no call 1769 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12480G>C, TP53_g.12480del, TP53_g.12480G>A, TP53_g.12480G>T, COSM45103, COSM11369, COSM1194556, COSM1194557, COSM1194559, COSM1194558 60 FFPE GACTG C/T TTGTA CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.439G>A p.V147I Gtt/Att chr17 7578491 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578491", "IGV") medium 0.258 4652 no call pass 14314 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12427del, TP53_g.12427G>A, TP53_g.12427G>T, COSM44698, COSM43985, COSM95384, COSM437583, COSM437584, COSM437586, COSM437585 deleterious(0.01) benign(0.158) 18 FFPE ATCAA C/T CCACA CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.469G>A p.V157I Gtc/Atc chr17 7578461 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578461", "IGV") low 0.079 4267 QD no call 1637 TP53_E00001255919_6 ENSG00000141510 5 of 11 rs121912654, TP53_g.12457del, TP53_g.12457G>A, TP53_g.12457G>C, TP53_g.12457G>T, COSM10670, COSM43625, COSM45120, COSM131480, COSM131481, COSM131483, COSM3388217, COSM1679513, COSM131482 tolerated(0.25) benign(0.362) uncertain_significance,pathogenic 17 FFPE GCGGA C/T GCGGG CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.467G>A p.R156H cGc/cAc chr17 7578463 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578463", "IGV") low 0.080 4267 QD no call 1741 TP53_E00001255919_6 ENSG00000141510 5 of 11 rs371524413, CM984589, TP53_g.12455G>A, TP53_g.12455del, TP53_g.12455G>C, TP53_g.12455G>T, COSM43548, COSM10760, COSM43739, COSM45530, COSM1522489, COSM3970367, COSM1522490, COSM3970370, COSM3970372, COSM1522492, COSM3712457, COSM3970369, COSM2744905, COSM3970368, COSM1522491, COSM3970371 tolerated(0.54) probably_damaging(0.979) 19 FFPE GGACG C/T GGGTG CMDL150111 FLD0208 FLD0232 intron TP53 c.74+56C>T chr17 7579783 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579783", "IGV") medium 0.653 1838 no call pass 36104 TP53_E00001596491_1 ENSG00000141510 2 of 10 6 FFPE TGCTA G/A GGGGC CMDL150111 FLD0208 FLD0232 intron TP53 c.74+43C>T chr17 7579796 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579796", "IGV") medium 0.488 2595 pass no call 23618 TP53_E00001596491_1 ENSG00000141510 2 of 10 19 FFPE GGGTT G/A GGGTG CMDL150111 FLD0208 FLD0232 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.996 0.996 2595 3690 pass pass 91133 145628 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150111 FLD0208 FLD0232 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") medium 0.657 3690 no call pass 54630 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL150111 FLD0208 FLD0232 intron TP53 c.375+22G>A chr17 7579290 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579290", "IGV") low 0.222 4965 QD no call 6636 TP53_E00001612188_1 ENSG00000141510 4 of 10 11 FFPE GGAAG C/T CAGCC CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.353C>T p.T118I aCa/aTa chr17 7579334 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579334", "IGV") low 0.149 5265 no call QD 5679 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11584C>T, TP53_g.11584C>G, COSM44051, COSM44990 deleterious(0) probably_damaging(1) 55 FFPE TGGCT G/A TCCCA CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.343C>T p.H115Y Cat/Tat chr17 7579344 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579344", "IGV") low 0.151 5265 no call QD 5914 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11574C>T deleterious(0.01) possibly_damaging(0.583) 62 FFPE AGAAT G/A CAAGA CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.287C>T p.S96F tCt/tTt chr17 7579400 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579400", "IGV") low 0.139 3989 no call QD 834 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11518C>T, TP53_g.11518C>G, COSM46273, COSM44447 tolerated(0.22) benign(0.026) 23 FFPE GGACA G/A AAGAT CMDL150111 FLD0208 FLD0232 synonymous TP53 c.252C>T c.252C>T(p.%3D) gcC/gcT chr17 7579435 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579435", "IGV") low 0.140 3989 no call QD 648 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs549892645, TP53_g.11483C>T, COSM45512 58 FFPE GCAGG G/A GCCGC CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.244C>T p.P82S Ccg/Tcg chr17 7579443 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579443", "IGV") low 0.147 3045 QD no call 1120 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11475C>T tolerated(0.38) benign(0.003) 58 FFPE CGCCG G/A TGTAG CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.993 0.997 3045 3989 pass pass 136378 172062 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150111 FLD0208 FLD0232 synonymous TP53 c.702C>T c.702C>T(p.%3D) taC/taT chr17 7577579 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577579", "IGV") low 0.141 5111 no call QD 132 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13339C>G, TP53_g.13339C>T, TP53_g.13339C>A, COSM45114, COSM45470, COSM1630412, COSM44785, COSM1324800, COSM1630413, COSM1600318, COSM1386634, COSM1386635, COSM1630414, COSM1324801, COSM1600319, COSM1630415, COSM1324802, COSM1600320, COSM1386636 33 FFPE TAGTT G/A TAGTG CMDL150111 FLD0208 FLD0232 synonymous TP53 c.1059C>G c.1059C>G(p.%3D) gcC/gcG chr17 7573968 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7573968", "IGV") low 0.093 3556 no call QD 3164 TP53_E00001728015_1 ENSG00000141510 10 of 11 69 FFPE GCCTG G/C GCATC CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.1057G>A p.A353T Gcc/Acc chr17 7573970 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573970", "IGV") low 0.092 3556 no call QD 3164 TP53_E00001728015_1 ENSG00000141510 10 of 11 TP53_g.16948G>A, COSM45292 tolerated(0.12) benign(0.248) 67 FFPE CTGGG C/T ATCCT CMDL150111 FLD0208 FLD0232 synonymous TP53 c.1041C>T c.1041C>T(p.%3D) gcC/gcT chr17 7573986 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573986", "IGV") low 0.167 3556 no call QD 2727 TP53_E00001728015_1 ENSG00000141510 10 of 11 COSM96587 51 FFPE TCCAA G/A GCCTC CMDL150111 FLD0208 FLD0232 3_prime_UTR TP53 c.*20C>T chr17 7572907 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572907", "IGV") medium 0.234 3205 no call pass 7970 TP53_E00001757276_1 ENSG00000141510 11 of 11 38 FFPE AGTGG G/A GAACA CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.1150A>G p.M384V Atg/Gtg chr17 7572959 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7572959", "IGV") low 0.151 1977 QD no call 506 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs730882009 deleterious(0.03) benign(0.022) uncertain_significance 52 FFPE GAACA T/C GAGTT CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.943T>C p.S315P Tct/Cct chr17 7576903 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7576903", "IGV") low 0.137 4906 QD no call 688 TP53_E00001789298_1 ENSG00000141510 9 of 11 rs762620193, TP53_g.14015T>C, TP53_g.14015del, COSM46110, COSM1386579 tolerated(0.12) possibly_damaging(0.775) uncertain_significance 61 FFPE GGGAG A/G GGAGC CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.941C>T p.S314F tCc/tTc chr17 7576905 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576905", "IGV") medium 0.361 4906 pass no call 29452 TP53_E00001789298_1 ENSG00000141510 9 of 11 rs751440465, TP53_g.14013C>T, COSM45914 deleterious(0.02) possibly_damaging(0.643) 59 FFPE GAGAG G/A AGCTG CMDL150111 FLD0208 FLD0232 intron TP53 c.920-11C>T chr17 7576937 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576937", "IGV") medium 0.147 2455 pass no call 6267 TP53_E00001789298_1 ENSG00000141510 8 of 10 27 FFPE AAAGA G/A GCAAG CMDL150111 FLD0208 FLD0232 intron TP53 c.920-31C>T chr17 7576957 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576957", "IGV") low 0.161 4844 QD no call 2103 TP53_E00001789298_2 ENSG00000141510 8 of 10 32 FFPE TAAAA G/A TGAAT CMDL150111 FLD0208 FLD0232 synonymous TP53 c.861G>A c.861G>A(p.%3D) gaG/gaA chr17 7577077 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577077", "IGV") medium 0.239 3501 pass no call 9021 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs748891343, TP53_g.13841G>T, TP53_g.13841G>A, TP53_g.13841G>C, COSM43776, COSM44077, COSM46366 55 FFPE AGATT C/T TCTTC CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.832C>T p.P278S Cct/Tct chr17 7577106 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577106", "IGV") medium 0.251 4423 no call pass 12792 TP53_E00001789298_3 25105660 ENSG00000141510 8 of 11 CM052927, CX0910928, rs17849781, CM011015, TP53_g.13812C>G, TP53_g.13812C>A, TP53_g.13812del, TP53_g.13812C>T, COSM43697, COSM10939, COSM10814, COSM45178, COSM368635, COSM139044, COSM99725, COSM3421932, COSM3773297, COSM3717626, COSM1646810, COSM1646809, COSM3421931 deleterious(0.03) probably_damaging(1) 61 FFPE CCCAG G/A ACAGG CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.824G>A p.C275Y tGt/tAt chr17 7577114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577114", "IGV") medium 0.250 4423 no call pass 13414 TP53_E00001789298_3 ENSG00000141510 8 of 11 CM951234, CM076568, TP53_g.13804G>A, TP53_g.13804del, TP53_g.13804G>C, TP53_g.13804G>T, COSM10701, COSM10893, COSM45413, COSM44178, COSM165084, COSM99932, COSM1167915, COSM318164, COSM3403255, COSM3723938, COSM1637959, COSM2744531, COSM1728541 deleterious(0) probably_damaging(0.994) 53 FFPE AGGCA C/T AAACA CMDL150111 FLD0208 FLD0232 nonsynonymous TP53 c.796G>A p.G266R Gga/Aga chr17 7577142 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577142", "IGV") medium 0.245 4423 no call pass 11063 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13776G>A, TP53_g.13776G>T, TP53_g.13776del, TP53_g.13776G>C, COSM44891, COSM10794, COSM11205, COSM45227, COSM1559475, COSM297539, COSM318165, COSM3388175, COSM1645293 deleterious(0.03) probably_damaging(0.999) 25 FFPE CCGTC C/T CAGTA CMDL150114 FLD0209 FLD0233 intron BRAF c.1742-21C>T chr7 140453214 G A =hyperlink("http://localhost:60151/goto?locus=chr7:140453214", "IGV") low 0.133 5953 no call QD 349 BRAF_AA_HS ENSG00000157764 14 of 17 20 FFPE TAAAG G/A AAAAC CMDL150114 FLD0209 FLD0233 intron EGFR c.2284-39C>T chr7 55248947 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248947", "IGV") low 0.097 1768 QD no call 1263 EGFR_E00001601336_1 ENSG00000146648 19 of 27 27 FFPE GCCAC C/T ATGCG CMDL150114 FLD0209 FLD0233 synonymous EGFR c.2310C>T c.2310C>T(p.%3D) gaC/gaT chr7 55249012 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249012", "IGV") low 0.170 2477 no call QD 1926 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs397517110 likely_benign 81 FFPE GTGGA C/T AACCC CMDL150114 FLD0209 FLD0233 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.616 0.686 1712 1204 pass pass 38559 31377 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150114 FLD0209 FLD0233 stop_gained EGFR c.2359C>T p.Q787* Cag/Tag chr7 55249061 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249061", "IGV") low 0.091 2439 no call QD 1325 EGFR_E00001601336_2 ENSG00000146648 20 of 28 40 FFPE CCGTG C/T AGCTC CMDL150114 FLD0209 FLD0233 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.577 0.571 2799 2495 pass pass 61374 54206 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150114 FLD0209 FLD0233 splice_region,synonymous EGFR c.2700C>T c.2700C>T(p.%3D) taC/taT chr7 55260533 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260533", "IGV") low 0.128 2593 QD no call 4195 EGFR_E00001631695_1 ENSG00000146648 22 of 28 rs530256683 T:0.0004 20 FFPE AGCTA C/T GGTGA CMDL150114 FLD0209 FLD0233 intron EGFR c.3115-42G>A chr7 55269386 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269386", "IGV") low 0.145 5295 no call QD 575 EGFR_E00001773562_1 ENSG00000146648 25 of 27 32 FFPE GATGT G/A GTACA CMDL150114 FLD0209 FLD0233 intron EGFR c.3115-25G>A chr7 55269403 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269403", "IGV") low 0.158 5295 no call QD 2663 EGFR_E00001773562_1 ENSG00000146648 25 of 27 49 FFPE CCATG G/A GCAAC CMDL150114 FLD0209 FLD0233 synonymous EGFR c.2706G>A c.2706G>A(p.%3D) gtG/gtA chr7 55266414 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266414", "IGV") medium 0.138 2566 pass no call 5588 EGFR_E00001779947_1 ENSG00000146648 23 of 28 31 FFPE GGGGT G/A ACTGT CMDL150114 FLD0209 FLD0233 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.996 0.998 2569 2485 pass pass 109607 105346 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150114 FLD0209 FLD0233 nonsynonymous EGFR c.2816G>A p.C939Y tGt/tAt chr7 55266524 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266524", "IGV") low 0.086 2475 no call QD 699 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(1) 28 FFPE CATAT G/A TACCA CMDL150114 FLD0209 FLD0233 splice_region,synonymous EGFR c.2946G>A c.2946G>A(p.%3D) caG/caA chr7 55268106 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268106", "IGV") medium 0.131 2506 pass no call 5106 EGFR_E00001790701_1 ENSG00000146648 24 of 28 8 FFPE ATTCA G/A GTACA CMDL150114 FLD0209 FLD0233 nonsynonymous TP53 c.79C>T p.P27S Cct/Tct chr17 7579717 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579717", "IGV") low 0.131 449 no call QD 170 EXP0116_TP53_E3 ENSG00000141510 3 of 11 TP53_g.11201del, COSM44957, COSM1167900, COSM1167901, COSM1167902, COSM3522717, COSM3522716, COSM1167903 tolerated(0.08) benign(0.219) 18 FFPE TTCAG G/A AAGTC CMDL150114 FLD0209 FLD0233 intron PTEN c.802-11T>C chr10 89720640 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720640", "IGV") medium 0.021 204 pass no call 597 PTEN_E00001156315_1m ENSG00000171862 7 of 8 45 FFPE TTTTT T/C TTTTT CMDL150114 FLD0209 FLD0233 intron PTEN c.801+13C>T chr10 89717789 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717789", "IGV") low 0.097 2292 no call QD 1737 PTEN_E00001156321_4m ENSG00000171862 7 of 8 20 FFPE CTTTA C/T TTTCA CMDL150114 FLD0209 FLD0233 intron PTEN c.801+151G>A chr10 89717927 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717927", "IGV") medium 0.183 2376 pass no call 9791 PTEN_E00001156321_4m ENSG00000171862 7 of 8 7 FFPE ATAAG G/A GTAAA CMDL150114 FLD0209 FLD0233 stop_gained PTEN c.445C>T p.Q149* Caa/Taa chr10 89692961 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692961", "IGV") low 0.157 4050 no call QD 1931 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CM110149, COSM5164 64 FFPE AGGCA C/T AAGAG CMDL150114 FLD0209 FLD0233 splice_donor PTEN c.492+1G>A chr10 89693009 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89693009", "IGV") low 0.106 1970 no call QD 1897 PTEN_E00001156330_3 ENSG00000171862 5 of 8 CD020869, COSM5973 16 FFPE AAAAG G/A TAAGT CMDL150114 FLD0209 FLD0233 nonsynonymous PTEN c.1079G>A p.S360N aGc/aAc chr10 89725096 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725096", "IGV") low 0.081 3297 QD no call 394 PTEN_E00001456541_2 ENSG00000171862 9 of 9 tolerated(0.12) possibly_damaging(0.706) 8 FFPE GGCTA G/A CAGTT CMDL150114 FLD0209 FLD0233 intron TP53 c.560-17T>C chr17 7578306 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7578306", "IGV") low 0.153 5475 no call QD 1909 TP53_E00001255919_3 ENSG00000141510 5 of 10 57 FFPE CAGTG A/G GGAAT CMDL150114 FLD0209 FLD0233 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.994 0.996 2739 2604 pass pass 75655 72746 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150114 FLD0209 FLD0233 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.995 0.995 3622 3284 pass pass 108406 97426 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150114 FLD0209 FLD0233 intron TP53 c.1100+35C>T chr17 7573892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573892", "IGV") low 0.080 2243 QD no call 124 TP53_E00001728015_1 ENSG00000141510 10 of 10 12 FFPE GGCAG G/A GGAGT CMDL150114 FLD0209 FLD0233 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.281 3734 pass no call 14092 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150114 FLD0209 FLD0233 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.477 3215 no call pass 29472 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150114 FLD0209 FLD0233 nonsynonymous TP53 c.839G>C p.R280T aGa/aCa chr17 7577099 C G =hyperlink("http://localhost:60151/goto?locus=chr17:7577099", "IGV") high 0.442 0.542 4919 4858 pass pass 40027 52243 TP53_E00001789298_3 ENSG00000141510 8 of 11 CM993218, rs121912660, TP53_g.13819G>C, TP53_g.13819G>T, TP53_g.13819G>A, COSM10724, COSM11287, COSM10728, COSM562340, COSM129830, COSM254987, COSM3522694, COSM3733332, COSM3723939, COSM1659144, COSM1646813, COSM1649340 deleterious(0) probably_damaging(0.947) uncertain_significance,pathogenic 68 FFPE GGTCT C/G TCCCA CMDL150115 FLD0210 FLD0234 intron EGFR c.2284-53C>T chr7 55248933 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248933", "IGV") medium 0.157 2002 pass no call 6477 EGFR_E00001601336_1 ENSG00000146648 19 of 27 13 FFPE TGCCC C/T TCCTT CMDL150115 FLD0210 FLD0234 intron EGFR c.2284-14C>T chr7 55248972 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248972", "IGV") medium 0.235 3472 no call pass 24197 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs776154077 52 FFPE TGCCT C/T TCCCT CMDL150115 FLD0210 FLD0234 splice_region,intron EGFR c.2284-7C>T chr7 55248979 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248979", "IGV") medium 0.229 3472 no call pass 10344 EGFR_E00001601336_1 ENSG00000146648 19 of 27 59 FFPE CCCTC C/T CTCCA CMDL150115 FLD0210 FLD0234 intron EGFR c.2702-11C>T chr7 55266399 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266399", "IGV") low 0.117 2507 QD no call 3850 EGFR_E00001779947_1 ENSG00000146648 22 of 27 16 FFPE TGCTT C/T ATCCT CMDL150115 FLD0210 FLD0234 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.752 0.642 2513 2184 pass pass 72300 52510 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150115 FLD0210 FLD0234 nonsynonymous EGFR c.2764G>A p.E922K Gag/Aag chr7 55266472 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266472", "IGV") low 0.157 4323 no call QD 714 EGFR_E00001779947_1 ENSG00000146648 23 of 28 COSM3639753 deleterious(0.05) benign(0.414) 80 FFPE CCAGC G/A AGATC CMDL150115 FLD0210 FLD0234 nonsynonymous KRAS c.34G>C p.G12R Ggt/Cgt chr12 25398285 C G =hyperlink("http://localhost:60151/goto?locus=chr12:25398285", "IGV") high 0.317 0.437 6451 5196 pass pass 29723 40722 KRAS_AA_HS ENSG00000133703 2 of 6 CM076251, COSM518, COSM517, COSM516, COSM1152506, COSM1157797, COSM1140136 deleterious(0.03) benign(0.376) 25 FFPE GCCAC C/G AGCTC CMDL150115 FLD0210 FLD0234 nonsynonymous KRAS c.16C>T p.L6F Ctt/Ttt chr12 25398303 G A =hyperlink("http://localhost:60151/goto?locus=chr12:25398303", "IGV") low 0.180 6451 QD no call 6665 KRAS_AA_HS ENSG00000133703 2 of 6 deleterious(0.01) probably_damaging(0.998) 7 FFPE CACAA G/A TTTAT CMDL150115 FLD0210 FLD0234 intron PTEN c.802-141G>A chr10 89720510 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720510", "IGV") low 0.101 2005 QD no call 2424 PTEN_E00001156315_1m ENSG00000171862 7 of 8 30 FFPE ATTCA G/A AATAT CMDL150115 FLD0210 FLD0234 intron PTEN c.801+75T>C chr10 89717851 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89717851", "IGV") low 0.202 3841 no call QD 5716 PTEN_E00001156321_4m ENSG00000171862 7 of 8 82 FFPE TGACA T/C GTAAG CMDL150115 FLD0210 FLD0234 intron PTEN c.801+128T>C chr10 89717904 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89717904", "IGV") medium 0.164 2180 pass no call 6539 PTEN_E00001156321_4m ENSG00000171862 7 of 8 30 FFPE TACTC T/C GGCAT CMDL150115 FLD0210 FLD0234 nonsynonymous,splice_region PTEN c.1027G>A p.V343M Gtg/Atg chr10 89725044 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725044", "IGV") low 0.161 5381 QD no call 1942 PTEN_E00001456541_1 ENSG00000171862 9 of 9 deleterious(0) probably_damaging(0.999) 22 FFPE TCTAG G/A TGAAG CMDL150115 FLD0210 FLD0234 nonsynonymous PTEN c.1111G>A p.D371N Gac/Aac chr10 89725128 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725128", "IGV") low 0.153 5381 QD no call 948 PTEN_E00001456541_1 ENSG00000171862 9 of 9 tolerated(0.19) probably_damaging(0.998) 33 FFPE TTAGT G/A ACAAT CMDL150115 FLD0210 FLD0234 nonsynonymous PTEN c.1085C>T p.S362L tCa/tTa chr10 89725102 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725102", "IGV") low 0.124 3361 QD no call 5715 PTEN_E00001456541_2 ENSG00000171862 9 of 9 deleterious(0.04) benign(0.282) 14 FFPE CAGTT C/T AACTT CMDL150115 FLD0210 FLD0234 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.002 1537 no call QD 784 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL150115 FLD0210 FLD0234 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.998 1537 no call QD 784 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150115 FLD0210 FLD0234 intron TP53 c.74+43C>T chr17 7579796 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579796", "IGV") low 0.186 3024 QD no call 4170 TP53_E00001596491_1 ENSG00000141510 2 of 10 19 FFPE GGGTT G/A GGGTG CMDL150115 FLD0210 FLD0234 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.996 0.995 3024 2434 pass pass 93420 69111 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150115 FLD0210 FLD0234 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.993 0.992 4004 3176 pass pass 115824 89882 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150115 FLD0210 FLD0234 nonsynonymous TP53 c.1004G>A p.R335H cGt/cAt chr17 7574023 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7574023", "IGV") low 0.086 1984 no call QD 263 TP53_E00001728015_1 ENSG00000141510 10 of 11 rs771939956, TP53_g.16895G>A, TP53_g.16895del, TP53_g.16895G>T, COSM295248, COSM45125, COSM295249 tolerated(0.15) benign(0.159) 14 FFPE GCTCA C/T GCCCA CMDL150115 FLD0210 FLD0234 3_prime_UTR TP53 c.*50C>T chr17 7572877 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572877", "IGV") low 0.122 1649 no call QD 2116 TP53_E00001757276_1 ENSG00000141510 11 of 11 8 FFPE GGGAG G/A GAGAG CMDL150115 FLD0210 FLD0234 3_prime_UTR TP53 c.*47C>T chr17 7572880 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572880", "IGV") medium 0.173 2006 pass no call 6955 TP53_E00001757276_1 ENSG00000141510 11 of 11 11 FFPE AGGGA G/A AGATG CMDL150115 FLD0210 FLD0234 3_prime_UTR TP53 c.*34C>T chr17 7572893 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572893", "IGV") medium 0.173 3478 pass no call 11592 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs545818827 A:0.0002 24 FFPE GGTGG G/A AGGCT CMDL150115 FLD0210 FLD0234 3_prime_UTR TP53 c.*24C>T chr17 7572903 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572903", "IGV") medium 0.171 3478 pass no call 7088 TP53_E00001757276_1 ENSG00000141510 11 of 11 34 FFPE TGTCA G/A TGGGG CMDL150181 FLD0211 FLD0235 intron EGFR c.2284-60T>C chr7 55248926 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55248926", "IGV") low 0.800 5 no call pass 127 EGFR_E00001601336_1 18199332, 21869887 ENSG00000146648 19 of 27 rs10241451 C:0.1743 6 FFPE GTCCA T/C GTGCC CMDL150181 FLD0211 FLD0235 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") low 0.800 5 no call pass 126 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150181 FLD0211 FLD0235 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.989 0.994 820 1004 pass pass 36015 49300 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150181 FLD0211 FLD0235 nonsynonymous EGFR c.2549A>G p.H850R cAt/cGt chr7 55259491 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55259491", "IGV") low 0.140 3959 QD no call 174 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM88211 deleterious(0) possibly_damaging(0.565) 35 FFPE GCAGC A/G TGTCA CMDL150181 FLD0211 FLD0235 nonsynonymous EGFR c.2507G>A p.R836H cGc/cAc chr7 55259449 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259449", "IGV") medium 0.390 3433 pass no call 22124 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs146121458, COSM133566 deleterious(0) probably_damaging(0.997) 33 FFPE GCACC G/A CGACC CMDL150181 FLD0211 FLD0235 synonymous EGFR c.2514G>A c.2514G>A(p.%3D) ctG/ctA chr7 55259456 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259456", "IGV") medium 0.291 3336 no call pass 11937 EGFR_E00001681524_2 ENSG00000146648 21 of 28 40 FFPE GACCT G/A GCAGC CMDL150181 FLD0211 FLD0235 nonsynonymous EGFR c.2563G>A p.D855N Gat/Aat chr7 55259505 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259505", "IGV") medium 0.327 3336 no call pass 14660 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM29577 deleterious(0) probably_damaging(0.988) 67 FFPE TCACA G/A ATTTT CMDL150181 FLD0211 FLD0235 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.997 1.000 2121 733 pass pass 89776 30970 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150181 FLD0211 FLD0235 synonymous EGFR c.2820C>T c.2820C>T(p.%3D) acC/acT chr7 55266528 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266528", "IGV") medium 0.408 733 no call pass 9861 EGFR_E00001779947_1 ENSG00000146648 23 of 28 COSM3639754 24 FFPE TGTAC C/T ATCGA CMDL150181 FLD0211 FLD0235 intron EGFR c.2848+40C>T chr7 55266596 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266596", "IGV") medium 0.806 3443 no call pass 63657 EGFR_E00001779947_2 ENSG00000146648 23 of 27 28 FFPE CTGAG C/T CTTGG CMDL150181 FLD0211 FLD0235 intron EGFR c.2848+55T>C chr7 55266611 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266611", "IGV") medium 0.194 1722 no call pass 7564 EGFR_E00001779947_2 ENSG00000146648 23 of 27 13 FFPE TGCTC T/C TAGCC CMDL150181 FLD0211 FLD0235 nonsynonymous EGFR c.2857A>G p.I953V Ata/Gta chr7 55268017 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55268017", "IGV") medium 0.300 1819 no call pass 7117 EGFR_E00001790701_1 ENSG00000146648 24 of 28 deleterious(0) possibly_damaging(0.817) 59 FFPE GGATG A/G TAGAC CMDL150181 FLD0211 FLD0235 splice_region,intron EGFR c.2947-6C>T chr7 55268875 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268875", "IGV") medium 0.912 3600 pass no call 91687 EGFR_E00001801208_1 ENSG00000146648 24 of 27 51 FFPE CTCTG C/T ACCAG CMDL150181 FLD0211 FLD0235 nonsynonymous EGFR c.3056C>T p.P1019L cCa/cTa chr7 55268990 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268990", "IGV") low 0.177 4662 no call QD 3959 EGFR_E00001801208_2 ENSG00000146648 25 of 28 COSM747423 deleterious(0) probably_damaging(0.998) 52 FFPE CATCC C/T ACAGC CMDL150181 FLD0211 FLD0235 nonsynonymous KRAS c.43G>A p.G15S Ggc/Agc chr12 25398276 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398276", "IGV") low 0.141 4467 no call QD 614 KRAS_AA_HS ENSG00000133703 2 of 6 COSM538 deleterious(0.02) probably_damaging(0.996) 34 FFPE CTTGC C/T TACGC CMDL150181 FLD0211 FLD0235 synonymous KRAS c.21G>A c.21G>A(p.%3D) gtG/gtA chr12 25398298 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398298", "IGV") medium 0.232 4467 no call pass 12172 KRAS_AA_HS ENSG00000133703 2 of 6 12 FFPE ACTAC C/T ACAAG CMDL150181 FLD0211 FLD0235 splice_region,intron PIK3CA c.1540-8T>C chr3 178935990 T C =hyperlink("http://localhost:60151/goto?locus=chr3:178935990", "IGV") low 0.089 569 no call QD 78 PIK3CA_Ex10_gap ENSG00000121879 9 of 20 26 FFPE TTTTA T/C TTTAC CMDL150181 FLD0211 FLD0235 3_prime_UTR PIK3CA c.*11G>A chr3 178952163 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178952163", "IGV") low 0.192 4154 no call QD 4371 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 rs758979440 45 FFPE TAACT G/A AGAAA CMDL150181 FLD0211 FLD0235 3_prime_UTR PIK3CA c.*41A>G chr3 178952193 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178952193", "IGV") medium 0.225 2345 pass no call 13186 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 15 FFPE TCCAC A/G CTGCA CMDL150181 FLD0211 FLD0235 nonsynonymous PTEN c.844G>A p.G282R Gga/Aga chr10 89720693 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720693", "IGV") low 0.163 4328 QD no call 7512 PTEN_E00001156315_5 ENSG00000171862 8 of 9 COSM1349599 tolerated(0.14) benign(0.043) 18 FFPE TACCA G/A GACCA CMDL150181 FLD0211 FLD0235 synonymous PTEN c.852G>A c.852G>A(p.%3D) gaG/gaA chr10 89720701 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720701", "IGV") low 0.163 4328 QD no call 7528 PTEN_E00001156315_5 ENSG00000171862 8 of 9 26 FFPE CCAGA G/A GAAAC CMDL150181 FLD0211 FLD0235 nonsynonymous PTEN c.881G>A p.S294N aGt/aAt chr10 89720730 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720730", "IGV") low 0.211 3367 no call QD 6201 PTEN_E00001156315_5 ENSG00000171862 8 of 9 COSM1717478 tolerated(0.2) benign(0.008) 42 FFPE TGGAA G/A TCTAT CMDL150181 FLD0211 FLD0235 intron PTEN c.801+76G>A chr10 89717852 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717852", "IGV") medium 0.959 1387 no call pass 38558 PTEN_E00001156321_4m ENSG00000171862 7 of 8 82 FFPE GACAT G/A TAAGG CMDL150181 FLD0211 FLD0235 nonsynonymous PTEN c.574G>A p.A192T Gca/Aca chr10 89711956 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89711956", "IGV") medium 0.814 2543 pass no call 52705 PTEN_E00001156327_4 ENSG00000171862 6 of 9 COSM1492349 tolerated(1) benign(0.007) 48 FFPE CAGTG G/A CACTG CMDL150181 FLD0211 FLD0235 nonsynonymous PTEN c.611C>T p.P204L cCa/cTa chr10 89711993 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711993", "IGV") medium 0.285 2685 no call pass 10079 PTEN_E00001156327_4 ENSG00000171862 6 of 9 COSM4165560, COSM1577256, COSM19563 deleterious(0.04) possibly_damaging(0.706) 57 FFPE TATTC C/T AATGT CMDL150181 FLD0211 FLD0235 intron PTEN c.634+11G>A chr10 89712027 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89712027", "IGV") medium 0.818 2543 pass no call 53194 PTEN_E00001156327_4 ENSG00000171862 6 of 8 rs773054934, COSM5897 23 FFPE TGCTT G/A AAATT CMDL150181 FLD0211 FLD0235 synonymous PTEN c.454C>T c.454C>T(p.%3D) Cta/Tta chr10 89692970 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692970", "IGV") medium 0.837 2726 pass no call 55959 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM1349547, COSM5180, COSM1349546 55 FFPE AGGCC C/T TAGAT CMDL150181 FLD0211 FLD0235 intron PTEN c.253+64A>G chr10 89690910 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89690910", "IGV") low 0.155 4749 no call QD 2547 PTEN_E00001156337_4 ENSG00000171862 4 of 8 2 FFPE CTGTC A/G TAACA CMDL150181 FLD0211 FLD0235 nonsynonymous PTEN c.88C>T p.P30S Cca/Tca chr10 89653790 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653790", "IGV") medium 0.566 2485 pass no call 29645 PTEN_E00001156351_1 ENSG00000171862 2 of 9 tolerated(0.08) benign(0.186) 23 FFPE TTTAT C/T CAAAC CMDL150181 FLD0211 FLD0235 nonsynonymous PTEN c.137A>G p.Y46C tAc/tGc chr10 89653839 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89653839", "IGV") low 0.122 81 no call LowQual,QD 17 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM1675407 deleterious(0.02) probably_damaging(0.997) 58 FFPE CGTAT A/G CAGGA CMDL150181 FLD0211 FLD0235 synonymous PTEN c.1041C>T c.1041C>T(p.%3D) ttC/ttT chr10 89725058 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725058", "IGV") medium 0.300 4460 pass no call 17811 PTEN_E00001456541_1 ENSG00000171862 9 of 9 COSM3807907 36 FFPE TACTT C/T ACAAA CMDL150181 FLD0211 FLD0235 nonsynonymous PTEN c.1156G>A p.D386N Gat/Aat chr10 89725173 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725173", "IGV") low 0.191 4862 no call QD 5379 PTEN_E00001456541_2 ENSG00000171862 9 of 9 deleterious_low_confidence(0.03) possibly_damaging(0.51) 68 FFPE ACTCT G/A ATCCA CMDL150181 FLD0211 FLD0235 synonymous PTEN c.75G>A c.75G>A(p.%3D) ttG/ttA chr10 89624301 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624301", "IGV") medium 0.272 4117 pass no call 13211 PTEN_E00001456562_1 ENSG00000171862 1 of 9 CM110137, COSM39165, COSM3967200 52 FFPE GACTT G/A ACCTG CMDL150181 FLD0211 FLD0235 intron PTEN c.79+37G>A chr10 89624342 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624342", "IGV") low 0.089 1711 no call QD 622 PTEN_E00001456562_1 ENSG00000171862 1 of 8 11 FFPE TTTCT G/A TCACT CMDL150181 FLD0211 FLD0235 intron TP53 c.993+176C>T chr17 7576677 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576677", "IGV") low 0.203 3636 QD no call 6009 TP53_00001404886_13 ENSG00000141510 9 of 10 38 FFPE TTATG G/A TATAA CMDL150181 FLD0211 FLD0235 nonsynonymous TP53 c.664C>T p.P222S Ccg/Tcg chr17 7578185 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578185", "IGV") low 0.163 2000 no call QD 1495 TP53_E00001255919_1 ENSG00000141510 6 of 11 TP53_g.12733C>A, TP53_g.12733C>T, TP53_g.12733del, TP53_g.12733C>G, COSM44970, COSM43607, COSM44270, COSM46254 tolerated(0.16) benign(0.038) 68 FFPE AGGCG G/A CTCAT CMDL150181 FLD0211 FLD0235 synonymous TP53 c.657C>T c.657C>T(p.%3D) ccC/ccT chr17 7578192 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578192", "IGV") medium 0.440 2000 no call pass 16898 TP53_E00001255919_1 ENSG00000141510 6 of 11 TP53_g.12726C>A, TP53_g.12726C>T, TP53_g.12726C>G, COSM1386663, COSM44689, COSM44799, COSM1386664, COSM1386665, COSM1386667, COSM1386666 61 FFPE TCATA G/A GGCAC CMDL150181 FLD0211 FLD0235 synonymous TP53 c.624C>T c.624C>T(p.%3D) gaC/gaT chr17 7578225 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578225", "IGV") low 0.163 2000 no call QD 1285 TP53_E00001255919_1 ENSG00000141510 6 of 11 TP53_g.12693C>T, TP53_g.12693C>G, TP53_g.12693C>A, COSM45851, COSM45707 28 FFPE TTTCT G/A TCATC CMDL150181 FLD0211 FLD0235 intron TP53 c.559+18G>A chr17 7578353 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578353", "IGV") low 0.145 5630 QD no call 1463 TP53_E00001255919_3 ENSG00000141510 5 of 10 rs772637453 37 FFPE TCTCT C/T CAGCC CMDL150181 FLD0211 FLD0235 nonsynonymous TP53 c.521G>A p.R174K aGg/aAg chr17 7578409 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578409", "IGV") low 0.167 4025 QD no call 3192 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12509G>A, TP53_g.12509G>T, TP53_g.12509del, TP53_g.12509G>C, COSM45498, COSM44524, COSM45671, COSM1630434, COSM1630435, COSM1630437, COSM1630436 tolerated(0.34) benign(0.041) 31 FFPE AGCGC C/T TCACA CMDL150181 FLD0211 FLD0235 splice_region,synonymous TP53 c.378C>T c.378C>T(p.%3D) taC/taT chr17 7578552 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578552", "IGV") low 0.667 12 no call pass 134 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12366C>G, TP53_g.12366C>A, TP53_g.12366C>T, COSM10862, COSM10888, COSM44196, COSM673517, COSM99946, COSM99944, COSM3723942, COSM2744959, COSM99945 22 FFPE GGGGA G/A TACTG CMDL150181 FLD0211 FLD0235 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.995 0.995 1265 1154 pass pass 34708 46733 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150181 FLD0211 FLD0235 intron TP53 c.74+12C>T chr17 7579827 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579827", "IGV") medium 0.515 1154 no call pass 23124 TP53_E00001596491_1 ENSG00000141510 2 of 10 TP53_g.11091C>T, COSM45967 50 FFPE CCAAT G/A GATCC CMDL150181 FLD0211 FLD0235 nonsynonymous TP53 c.61G>A p.D21N Gac/Aac chr17 7579852 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579852", "IGV") medium 0.479 1154 no call pass 21201 TP53_E00001596491_1 ENSG00000141510 2 of 11 tolerated(0.06) possibly_damaging(0.579) 71 FFPE TAGGT C/T TGAAA CMDL150181 FLD0211 FLD0235 synonymous TP53 c.15G>A c.15G>A(p.%3D) caG/caA chr17 7579898 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579898", "IGV") low 0.132 1262 QD no call 262 TP53_E00001596491_1 ENSG00000141510 2 of 11 TP53_g.11020G>T, COSM45588 25 FFPE TCTGA C/T TGCGG CMDL150181 FLD0211 FLD0235 nonsynonymous TP53 c.296C>T p.S99F tCc/tTc chr17 7579391 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579391", "IGV") low 0.200 2591 no call QD 3549 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11527C>T, COSM44036 deleterious(0.01) probably_damaging(0.978) 14 FFPE TCTGG G/A AAGGG CMDL150181 FLD0211 FLD0235 synonymous TP53 c.264C>T c.264C>T(p.%3D) gcC/gcT chr17 7579423 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579423", "IGV") low 0.154 2591 no call QD 1343 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11495C>T 46 FFPE GAGGG G/A GCTGG CMDL150181 FLD0211 FLD0235 nonsynonymous TP53 c.256G>A p.A86T Gca/Aca chr17 7579431 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579431", "IGV") medium 0.304 3088 pass no call 13466 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs587782148 tolerated(0.62) benign(0.005) uncertain_significance 54 FFPE TGGTG C/T AGGGG CMDL150181 FLD0211 FLD0235 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.987 0.995 3088 2591 pass pass 89812 97597 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150181 FLD0211 FLD0235 nonsynonymous TP53 c.212C>T p.P71L cCc/cTc chr17 7579475 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579475", "IGV") low 0.185 2591 no call QD 3149 TP53_E00001612188_2 ENSG00000141510 4 of 11 tolerated(0.57) benign(0.004) 26 FFPE CGGGG G/A GAGCA CMDL150181 FLD0211 FLD0235 nonsynonymous TP53 c.742C>T p.R248W Cgg/Tgg chr17 7577539 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577539", "IGV") medium 0.997 3711 pass no call 108457 TP53_E00001665758_1 ENSG00000141510 7 of 11 CM010465, CM900211, rs121912651, TP53_g.13379C>G, TP53_g.13379C>T, TP53_g.13379C>A, TP53_g.13379del, COSM11564, COSM45116, COSM10656, COSM44920, COSM120007, COSM1189381, COSM120005, COSM1189382, COSM3388183, COSM1640831, COSM120006, COSM1189383 deleterious(0) probably_damaging(1) pathogenic 73 FFPE CCTCC G/A GTTCA CMDL150181 FLD0211 FLD0235 splice_region,intron TP53 c.1100+3G>A chr17 7573924 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573924", "IGV") medium 0.333 2979 no call pass 15397 TP53_E00001728015_1 ENSG00000141510 10 of 10 44 FFPE TCACT C/T ACCTG CMDL150181 FLD0211 FLD0235 nonsynonymous TP53 c.1006G>A p.E336K Gag/Aag chr17 7574021 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7574021", "IGV") medium 0.209 1910 pass no call 9744 TP53_E00001728015_1 ENSG00000141510 10 of 11 CM044725, TP53_g.16897G>T, COSM11291, COSM1522200 tolerated(0.31) benign(0.019) 16 FFPE GCGCT C/T ACGCC CMDL150181 FLD0211 FLD0235 splice_acceptor TP53 c.1101-2A>C chr17 7573010 T G =hyperlink("http://localhost:60151/goto?locus=chr17:7573010", "IGV") medium 0.335 313 no call pass 3373 TP53_E00001757276_1 ENSG00000141510 10 of 10 rs587781664, CS111031, TP53_g.17908A>G, TP53_g.17908A>T, TP53_g.17908A>C, COSM1191161, COSM12663, COSM45409, COSM1386548, COSM1679487 1 FFPE GTGGC T/G GTAGG CMDL150181 FLD0211 FLD0235 splice_region,intron TP53 c.993+8G>A chr17 7576845 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576845", "IGV") medium 0.659 4534 pass no call 68986 TP53_E00001789298_1 ENSG00000141510 9 of 10 TP53_g.14073G>A 39 FFPE CAAGA C/T TTAGT CMDL150181 FLD0211 FLD0235 intron TP53 c.919+23G>A chr17 7576996 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576996", "IGV") medium 0.769 4388 pass no call 79328 TP53_E00001789298_2 ENSG00000141510 8 of 10 rs376079415 60 FFPE TCCAC C/T GCTTC CMDL150181 FLD0211 FLD0235 nonsynonymous TP53 c.892G>A p.E298K Gag/Aag chr17 7577046 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577046", "IGV") medium 0.773 4388 pass no call 79058 TP53_E00001789298_2 ENSG00000141510 8 of 11 rs201744589, CM031387, TP53_g.13872G>A, TP53_g.13872G>T, TP53_g.13872G>C, TP53_g.13872del, COSM44031, COSM10710, COSM45938, COSM121080, COSM3723940, COSM1646820 tolerated(0.41) benign(0.004) likely_benign,pathogenic T:0.0002 10 FFPE CAGCT C/T GTGGT CMDL150181 FLD0211 FLD0235 nonsynonymous TP53 c.826G>A p.A276T Gcc/Acc chr17 7577112 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577112", "IGV") medium 0.317 4145 pass no call 17948 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13806G>C, TP53_g.13806G>A, TP53_g.13806del, TP53_g.13806G>T, COSM43663, COSM44114, COSM45467, COSM308313, COSM3937595, COSM3937594 tolerated(0.1) probably_damaging(0.985) 55 FFPE ACAGG C/T ACAAA CMDL150182 FLD0212 FLD0236 nonsynonymous BRAF c.1786G>A p.G596S Ggt/Agt chr7 140453149 C T =hyperlink("http://localhost:60151/goto?locus=chr7:140453149", "IGV") low 0.171 5483 no call QD 4336 BRAF_AA_HS ENSG00000157764 15 of 18 rs121913361, COSM469, COSM36922 deleterious(0) probably_damaging(0.975) uncertain_significance 23 FFPE TAGAC C/T AAAAT CMDL150182 FLD0212 FLD0236 intron BRAF c.1742-28C>T chr7 140453221 G A =hyperlink("http://localhost:60151/goto?locus=chr7:140453221", "IGV") low 0.166 5483 no call QD 2872 BRAF_AA_HS ENSG00000157764 14 of 17 13 FFPE AAACA G/A TAGAT CMDL150182 FLD0212 FLD0236 intron EGFR c.2284-21C>T chr7 55248965 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248965", "IGV") medium 0.568 1443 no call pass 17752 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs201251727 T:0.0012 45 FFPE ACTGA C/T GTGCC CMDL150182 FLD0212 FLD0236 nonsynonymous EGFR c.2348C>T p.T783I aCc/aTc chr7 55249050 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249050", "IGV") low 0.190 1443 no call QD 1733 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM14069 deleterious(0) probably_damaging(0.999) 43 FFPE CCTCA C/T CTCCA CMDL150182 FLD0212 FLD0236 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.985 0.985 1262 836 pass pass 52359 35595 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150182 FLD0212 FLD0236 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.996 0.996 2475 2364 pass pass 115575 110637 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150182 FLD0212 FLD0236 intron EGFR c.2626-54C>T chr7 55260405 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260405", "IGV") medium 0.208 2815 no call pass 10002 EGFR_E00001631695_1 ENSG00000146648 21 of 27 18 FFPE TTTTT C/T CAACA CMDL150182 FLD0212 FLD0236 intron EGFR c.2701+16G>A chr7 55260550 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260550", "IGV") low 0.115 2447 QD no call 3402 EGFR_E00001631695_1 ENSG00000146648 22 of 27 3 FFPE ATCCT G/A ATGCT CMDL150182 FLD0212 FLD0236 intron EGFR c.2470-27C>T chr7 55259385 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259385", "IGV") low 0.114 2556 QD no call 3716 EGFR_E00001681524_1 ENSG00000146648 20 of 27 14 FFPE TGTCC C/T TCACA CMDL150182 FLD0212 FLD0236 intron EGFR c.2470-25C>T chr7 55259387 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259387", "IGV") low 0.132 2650 no call QD 5079 EGFR_E00001681524_1 ENSG00000146648 20 of 27 16 FFPE TCCCT C/T ACAGC CMDL150182 FLD0212 FLD0236 synonymous EGFR c.2574G>A c.2574G>A(p.%3D) ctG/ctA chr7 55259516 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259516", "IGV") low 0.214 3435 no call QD 6213 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs397517129, COSM133590 uncertain_significance 56 FFPE GGGCT G/A GCCAA CMDL150182 FLD0212 FLD0236 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.997 0.998 2384 2250 pass pass 100760 95325 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150182 FLD0212 FLD0236 intron EGFR c.2848+35C>T chr7 55266591 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266591", "IGV") medium 0.247 5183 pass no call 13146 EGFR_E00001779947_2 ENSG00000146648 23 of 27 33 FFPE CCTAG C/T TGAGC CMDL150182 FLD0212 FLD0236 intron EGFR c.2947-33G>A chr7 55268848 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268848", "IGV") low 0.159 5627 no call QD 2308 EGFR_E00001801208_1 ENSG00000146648 24 of 27 24 FFPE TACGG G/A CCATT CMDL150182 FLD0212 FLD0236 synonymous EGFR c.3003G>A c.3003G>A(p.%3D) ctG/ctA chr7 55268937 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268937", "IGV") low 0.148 5627 no call QD 1638 EGFR_E00001801208_1 ENSG00000146648 25 of 28 31 FFPE GCCCT G/A ATGGA CMDL150182 FLD0212 FLD0236 nonsynonymous EGFR c.3022G>A p.D1008N Gac/Aac chr7 55268956 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268956", "IGV") medium 0.346 5912 pass no call 31204 EGFR_E00001801208_2 ENSG00000146648 25 of 28 tolerated(0.12) benign(0.002) 18 FFPE ACATG G/A ACGAC CMDL150182 FLD0212 FLD0236 synonymous EGFR c.3027C>T c.3027C>T(p.%3D) gaC/gaT chr7 55268961 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268961", "IGV") medium 0.361 5172 no call pass 29241 EGFR_E00001801208_2 ENSG00000146648 25 of 28 rs754193639 23 FFPE GACGA C/T GTGGT CMDL150182 FLD0212 FLD0236 nonsynonymous EGFR c.3064G>A p.G1022S Ggc/Agc chr7 55268998 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268998", "IGV") low 0.157 5172 no call QD 2674 EGFR_E00001801208_2 ENSG00000146648 25 of 28 COSM133564 tolerated(0.11) benign(0.081) 60 FFPE AGCAG G/A GCTTC CMDL150182 FLD0212 FLD0236 splice_region,synonymous EGFR c.3114G>A c.3114G>A(p.%3D) ctG/ctA chr7 55269048 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269048", "IGV") low 0.153 5172 no call QD 2629 EGFR_E00001801208_2 ENSG00000146648 25 of 28 31 FFPE TCTCT G/A GTATG CMDL150182 FLD0212 FLD0236 intron EGFR c.3114+10C>T chr7 55269058 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269058", "IGV") low 0.144 5823 QD no call 1064 EGFR_E00001801208_2 ENSG00000146648 25 of 27 rs755627760 21 FFPE GAAAT C/T TCTGT CMDL150182 FLD0212 FLD0236 nonsynonymous EGFR c.2206G>A p.E736K Gag/Aag chr7 55242436 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55242436", "IGV") low 0.137 6338 QD no call 401 EGFR_Exon19 ENSG00000146648 19 of 28 deleterious(0) probably_damaging(0.999) 42 FFPE AAGGT G/A AGAAA CMDL150182 FLD0212 FLD0236 nonsynonymous EGFR c.2212G>A p.V738I Gtt/Att chr7 55242442 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55242442", "IGV") low 0.167 6338 QD no call 3919 EGFR_Exon19 ENSG00000146648 19 of 28 tolerated(0.13) benign(0.063) 48 FFPE AGAAA G/A TTAAA CMDL150182 FLD0212 FLD0236 nonsynonymous TP53 c.167A>G p.E56G gAa/gGa chr17 7579520 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7579520", "IGV") medium 0.225 4175 pass no call 11149 EXP0116_TP53_E4 ENSG00000141510 4 of 11 TP53_g.11398A>T, COSM45710 tolerated(0.11) benign(0.003) 24 FFPE GGTCT T/C CAGTG CMDL150182 FLD0212 FLD0236 nonsynonymous TP53 c.164C>T p.T55I aCt/aTt chr17 7579523 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579523", "IGV") low 0.174 4175 QD no call 5606 EXP0116_TP53_E4 ENSG00000141510 4 of 11 TP53_g.11395C>T tolerated(0.12) benign(0.013) 27 FFPE CTTCA G/A TGAAC CMDL150182 FLD0212 FLD0236 nonsynonymous TP53 c.116C>T p.A39V gCa/gTa chr17 7579571 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579571", "IGV") medium 0.214 4354 no call pass 9786 EXP0116_TP53_E4 ENSG00000141510 4 of 11 TP53_g.11347C>T tolerated(0.27) benign(0.027) 36 FFPE CCATT G/A CTTGG CMDL150182 FLD0212 FLD0236 intron PIK3CA c.1540-20G>A chr3 178935978 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178935978", "IGV") medium 0.284 604 no call pass 5141 PIK3CA_Ex10_gap ENSG00000121879 9 of 20 rs752500943 14 FFPE TATAA G/A ATATT CMDL150182 FLD0212 FLD0236 nonsynonymous PIK3CA c.3155C>T p.T1052I aCa/aTa chr3 178952100 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178952100", "IGV") medium 0.250 5167 pass no call 12645 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 COSM17447, COSM33601, COSM1220594 deleterious(0) possibly_damaging(0.886) 43 FFPE CTGGA C/T AACAA CMDL150182 FLD0212 FLD0236 synonymous PIK3CA c.3174C>T c.3174C>T(p.%3D) atC/atT chr3 178952119 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178952119", "IGV") low 0.150 5431 no call QD 274 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 62 FFPE TGGAT C/T TTCCA CMDL150182 FLD0212 FLD0236 3_prime_UTR PIK3CA c.*39A>G chr3 178952191 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178952191", "IGV") low 0.084 2613 QD no call 159 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 17 FFPE ATTCC A/G CACTG CMDL150182 FLD0212 FLD0236 intron PTEN c.802-39C>T chr10 89720612 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720612", "IGV") medium 0.418 112 no call pass 286 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs770794279 73 FFPE TATGT C/T ATTTC CMDL150182 FLD0212 FLD0236 intron PTEN c.802-34C>T chr10 89720617 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720617", "IGV") medium 0.283 106 no call pass 260 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs531071483 68 FFPE CATTT C/T ATTTC CMDL150182 FLD0212 FLD0236 splice_region,intron PTEN c.802-8T>C chr10 89720643 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720643", "IGV") low 0.005 107 no call LowQual,QD 16 PTEN_E00001156315_1m ENSG00000171862 7 of 8 42 FFPE TTTTT T/C TTTTT CMDL150182 FLD0212 FLD0236 nonsynonymous PTEN c.901G>A p.D301N Gat/Aat chr10 89720750 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720750", "IGV") medium 0.237 3233 no call pass 20180 PTEN_E00001156315_7 ENSG00000171862 8 of 9 rs758644748, COSM921144 tolerated(0.35) benign(0.002) 18 FFPE AAATC G/A ATAGC CMDL150182 FLD0212 FLD0236 nonsynonymous PTEN c.926C>T p.A309V gCa/gTa chr10 89720775 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720775", "IGV") low 0.202 6533 no call QD 10421 PTEN_E00001156315_7 ENSG00000171862 8 of 9 tolerated(0.34) benign(0.02) 43 FFPE GCGTG C/T AGATA CMDL150182 FLD0212 FLD0236 nonsynonymous PTEN c.998C>T p.A333V gCc/gTc chr10 89720847 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720847", "IGV") low 0.158 6546 QD no call 692 PTEN_E00001156315_7 ENSG00000171862 8 of 9 tolerated(0.19) possibly_damaging(0.783) 49 FFPE CAAAG C/T CAACC CMDL150182 FLD0212 FLD0236 intron PTEN c.635-34G>A chr10 89717576 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717576", "IGV") low 0.123 2557 no call QD 1817 PTEN_E00001156321_1 ENSG00000171862 6 of 8 rs777358609 6 FFPE TTCCT G/A TGAAA CMDL150182 FLD0212 FLD0236 nonsynonymous PTEN c.742C>T p.P248S Cct/Tct chr10 89717717 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717717", "IGV") low 0.207 4758 no call QD 7597 PTEN_E00001156321_2 ENSG00000171862 7 of 9 tolerated(0.06) benign(0.309) 59 FFPE CGTTA C/T CTGTG CMDL150182 FLD0212 FLD0236 synonymous PTEN c.774C>T c.774C>T(p.%3D) ttC/ttT chr10 89717749 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717749", "IGV") low 0.135 4758 no call QD 573 PTEN_E00001156321_2 ENSG00000171862 7 of 9 COSM921131, COSM3807906 27 FFPE TTCTT C/T CACAA CMDL150182 FLD0212 FLD0236 nonsynonymous PTEN c.790A>G p.M264V Atg/Gtg chr10 89717765 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717765", "IGV") low 0.201 4758 no call QD 8854 PTEN_E00001156321_2 ENSG00000171862 7 of 9 tolerated(0.25) benign(0.002) 11 FFPE ACAAG A/G TGCTA CMDL150182 FLD0212 FLD0236 nonsynonymous PTEN c.523G>A p.V175M Gtg/Atg chr10 89711905 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89711905", "IGV") low 0.219 5223 no call QD 10091 PTEN_E00001156327_1 ENSG00000171862 6 of 9 COSM76106 deleterious(0.03) probably_damaging(0.948) 13 FFPE GCTAT G/A TGTAT CMDL150182 FLD0212 FLD0236 nonsynonymous PTEN c.322C>T p.L108F Ctt/Ttt chr10 89692838 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692838", "IGV") low 0.196 5139 no call QD 5037 PTEN_E00001156330_1 ENSG00000171862 5 of 9 deleterious(0.01) possibly_damaging(0.889) 61 FFPE AAGAT C/T TTGAC CMDL150182 FLD0212 FLD0236 synonymous PTEN c.351T>C c.351T>C(p.%3D) aaT/aaC chr10 89692867 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89692867", "IGV") low 0.108 1120 no call QD 923 PTEN_E00001156330_3 ENSG00000171862 5 of 9 4 FFPE GACAA T/C CATGT CMDL150182 FLD0212 FLD0236 splice_region,intron PTEN c.253+5G>A chr10 89690851 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89690851", "IGV") medium 0.227 4854 no call pass 11512 PTEN_E00001156337_4 ENSG00000171862 4 of 8 COSM24686 43 FFPE GGTAG G/A TATGA CMDL150182 FLD0212 FLD0236 nonsynonymous PTEN c.1085C>T p.S362L tCa/tTa chr10 89725102 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725102", "IGV") medium 0.311 5386 no call pass 22748 PTEN_E00001456541_1 ENSG00000171862 9 of 9 deleterious(0.04) benign(0.282) 59 FFPE CAGTT C/T AACTT CMDL150182 FLD0212 FLD0236 nonsynonymous PTEN c.1088C>T p.T363I aCt/aTt chr10 89725105 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725105", "IGV") medium 0.138 3127 pass no call 7614 PTEN_E00001456541_2 ENSG00000171862 9 of 9 rs750585255 tolerated(0.13) benign(0.007) 17 FFPE TTCAA C/T TTCTG CMDL150182 FLD0212 FLD0236 5_prime_UTR PTEN c.-11G>A chr10 89624216 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624216", "IGV") low 0.086 2187 no call QD 748 PTEN_E00001456562_1 ENSG00000171862 1 of 9 rs756632919 22 FFPE CCACA G/A GCTCC CMDL150182 FLD0212 FLD0236 intron PTEN c.79+39C>T chr10 89624344 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624344", "IGV") low 0.124 2268 QD no call 3459 PTEN_E00001456562_1 ENSG00000171862 1 of 8 9 FFPE TCTGT C/T ACTCT CMDL150182 FLD0212 FLD0236 intron TP53 c.672+23C>T chr17 7578154 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578154", "IGV") low 0.187 3251 QD no call 4120 TP53_E00001255919_1 ENSG00000141510 6 of 10 45 FFPE TCCCA G/A AGACC CMDL150182 FLD0212 FLD0236 nonsynonymous TP53 c.628A>G p.N210D Aac/Gac chr17 7578221 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578221", "IGV") low 0.163 3684 no call QD 2683 TP53_E00001255919_1 ENSG00000141510 6 of 11 CM004573, TP53_g.12697A>C, TP53_g.12697del, TP53_g.12697A>T, TP53_g.12697A>G, COSM44087, COSM43641, COSM43933, COSM1386689, COSM1386690, COSM1386692, COSM1386691 tolerated(0.08) benign(0.195) 32 FFPE AGTGT T/C TCTGT CMDL150182 FLD0212 FLD0236 intron TP53 c.560-38G>A chr17 7578327 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578327", "IGV") low 0.173 4988 QD no call 2720 TP53_E00001255919_3 ENSG00000141510 5 of 10 63 FFPE GGGAC C/T CTGGG CMDL150182 FLD0212 FLD0236 intron TP53 c.559+9C>T chr17 7578362 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578362", "IGV") medium 0.301 4988 pass no call 19287 TP53_E00001255919_3 ENSG00000141510 5 of 10 TP53_g.12556C>T, COSM43927 28 FFPE CCCCA G/A CTGCT CMDL150182 FLD0212 FLD0236 synonymous TP53 c.540G>A c.540G>A(p.%3D) gaG/gaA chr17 7578390 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578390", "IGV") medium 0.514 4378 pass no call 42892 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12528G>C, TP53_g.12528G>T, COSM45372, COSM44740, COSM323930, COSM323929, COSM323931, COSM3717658, COSM3717657, COSM323932 12 FFPE CAGCG C/T TCATG CMDL150182 FLD0212 FLD0236 synonymous TP53 c.456G>A c.456G>A(p.%3D) ccG/ccA chr17 7578474 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578474", "IGV") medium 0.279 3380 no call pass 12097 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12444G>C, TP53_g.12444G>A, TP53_g.12444del, TP53_g.12444G>T, COSM44061, COSM44958, COSM45197, COSM1640854, COSM1640856, COSM1640858, COSM1640855, COSM1640857 35 FFPE CCGGG C/T GGGGG CMDL150182 FLD0212 FLD0236 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.996 0.993 2666 2148 pass pass 107794 76196 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150182 FLD0212 FLD0236 intron TP53 c.74+16G>A chr17 7579823 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579823", "IGV") medium 0.269 2148 no call pass 6641 TP53_E00001596491_1 ENSG00000141510 2 of 10 46 FFPE CCTTC C/T AATGG CMDL150182 FLD0212 FLD0236 synonymous TP53 c.54A>G c.54A>G(p.%3D) acA/acG chr17 7579859 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7579859", "IGV") medium 0.219 2666 pass no call 6347 TP53_E00001596491_1 ENSG00000141510 2 of 11 TP53_g.11059A>T, COSM45385 64 FFPE GAAAA T/C GTTTC CMDL150182 FLD0212 FLD0236 synonymous TP53 c.40C>T c.40C>T(p.%3D) Ctg/Ttg chr17 7579873 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579873", "IGV") low 0.086 2666 QD no call 1874 TP53_E00001596491_1 ENSG00000141510 2 of 11 50 FFPE ACTCA G/A AGGGG CMDL150182 FLD0212 FLD0236 nonsynonymous TP53 c.31G>A p.E11K Gag/Aag chr17 7579882 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579882", "IGV") low 0.195 2666 QD no call 4510 TP53_E00001596491_1 ENSG00000141510 2 of 11 rs201382018, TP53_g.11036G>C, TP53_g.11036G>A, COSM11606, COSM3820734, COSM327260, COSM3820735, COSM327259, COSM3820738, COSM3820737, COSM3820736, COSM327261, COSM3820739 deleterious(0.02) possibly_damaging(0.853) uncertain_significance G:0.0002 41 FFPE GGGCT C/T GACGC CMDL150182 FLD0212 FLD0236 synonymous TP53 c.30C>T c.30C>T(p.%3D) gtC/gtT chr17 7579883 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579883", "IGV") low 0.088 2666 QD no call 2006 TP53_E00001596491_1 ENSG00000141510 2 of 11 TP53_g.11035C>T, COSM984987, COSM984988, COSM984990, COSM984991 40 FFPE GGCTC G/A ACGCT CMDL150182 FLD0212 FLD0236 synonymous TP53 c.357C>T c.357C>T(p.%3D) gcC/gcT chr17 7579330 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579330", "IGV") low 0.204 4833 no call QD 7888 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11588C>G, TP53_g.11588C>A, TP53_g.11588C>T, COSM43668, COSM46304, COSM122107, COSM984972, COSM984974, COSM122108 51 FFPE GACTT G/A GCTGT CMDL150182 FLD0212 FLD0236 stop_gained TP53 c.310C>T p.Q104* Cag/Tag chr17 7579377 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579377", "IGV") medium 0.209 4791 pass no call 10154 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11541C>T, TP53_g.11541del, COSM10886, COSM308172, COSM308171, COSM3727867, COSM2745029 29 FFPE GCCCT G/A GTAGG CMDL150182 FLD0212 FLD0236 synonymous TP53 c.252C>T c.252C>T(p.%3D) gcC/gcT chr17 7579435 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579435", "IGV") medium 0.160 3341 no call pass 8100 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs549892645, TP53_g.11483C>T, COSM45512 58 FFPE GCAGG G/A GCCGC CMDL150182 FLD0212 FLD0236 nonsynonymous TP53 c.223C>T p.P75S Cct/Tct chr17 7579464 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579464", "IGV") low 0.094 3341 no call QD 3759 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11454C>T, TP53_g.11454del, COSM44803, COSM46193 tolerated(0.81) benign(0.009) 37 FFPE TGCAG G/A GGCCA CMDL150182 FLD0212 FLD0236 synonymous TP53 c.216C>T c.216C>T(p.%3D) ccC/ccT chr17 7579471 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579471", "IGV") low 0.091 3341 no call QD 3759 TP53_E00001612188_2 ENSG00000141510 4 of 11 COSM18569, COSM1268331, COSM1268332 30 FFPE GCCAC G/A GGGGG CMDL150182 FLD0212 FLD0236 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.996 0.995 3343 3341 pass pass 108302 121242 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150182 FLD0212 FLD0236 intron TP53 c.782+15G>A chr17 7577484 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577484", "IGV") medium 0.644 3083 no call pass 42033 TP53_E00001665758_1 ENSG00000141510 7 of 10 35 FFPE GGTGG C/T AAGTG CMDL150182 FLD0212 FLD0236 splice_region,intron TP53 c.1100+5G>A chr17 7573922 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573922", "IGV") low 0.169 3335 no call QD 2472 TP53_E00001728015_1 ENSG00000141510 10 of 10 42 FFPE GGTCA C/T TCACC CMDL150182 FLD0212 FLD0236 synonymous TP53 c.1068G>A c.1068G>A(p.%3D) ggG/ggA chr17 7573959 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573959", "IGV") low 0.145 3335 no call QD 824 TP53_E00001728015_1 ENSG00000141510 10 of 11 78 FFPE TCCTT C/T CCAGC CMDL150182 FLD0212 FLD0236 stop_gained TP53 c.1024C>T p.R342* Cga/Tga chr17 7574003 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7574003", "IGV") medium 0.172 0.426 4072 3335 QD pass 3794 24158 TP53_E00001728015_1 ENSG00000141510 10 of 11 rs730882029, CM004908, TP53_g.16915del, TP53_g.16915C>T, COSM11073, COSM45639, COSM18597, COSM99721, COSM128665 pathogenic 34 FFPE CTCTC G/A GAACA CMDL150182 FLD0212 FLD0236 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") medium 0.358 3611 pass no call 22170 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL150182 FLD0212 FLD0236 3_prime_UTR TP53 c.*19C>T chr17 7572908 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572908", "IGV") low 0.170 3611 QD no call 4111 TP53_E00001757276_1 ENSG00000141510 11 of 11 39 FFPE GTGGG G/A AACAA CMDL150182 FLD0212 FLD0236 intron TP53 c.993+30G>A chr17 7576823 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576823", "IGV") medium 0.145 3189 no call pass 8289 TP53_E00001789298_1 ENSG00000141510 9 of 10 17 FFPE CTTTC C/T ACTTG CMDL150182 FLD0212 FLD0236 nonsynonymous TP53 c.926C>T p.P309L cCc/cTc chr17 7576920 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576920", "IGV") medium 0.255 6033 no call pass 17157 TP53_E00001789298_1 ENSG00000141510 9 of 11 TP53_g.13998C>T, TP53_g.13998C>G, TP53_g.13998C>A, COSM45616 tolerated(0.06) possibly_damaging(0.796) 44 FFPE TGTTG G/A GCAGT CMDL150182 FLD0212 FLD0236 nonsynonymous TP53 c.905G>A p.G302E gGg/gAg chr17 7577033 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577033", "IGV") low 0.082 1901 QD no call 633 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13885G>A, TP53_g.13885G>C, TP53_g.13885G>T, COSM43988 tolerated(0.11) benign(0.082) 11 FFPE TGCTC C/T CTGGG CMDL150182 FLD0212 FLD0236 nonsynonymous TP53 c.892G>A p.E298K Gag/Aag chr17 7577046 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577046", "IGV") medium 0.273 3672 no call pass 14584 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs201744589, CM031387, TP53_g.13872G>A, TP53_g.13872G>T, TP53_g.13872G>C, TP53_g.13872del, COSM44031, COSM10710, COSM45938, COSM121080, COSM3723940, COSM1646820 tolerated(0.41) benign(0.004) likely_benign,pathogenic T:0.0002 24 FFPE CAGCT C/T GTGGT CMDL150182 FLD0212 FLD0236 nonsynonymous TP53 c.886C>T p.H296Y Cac/Tac chr17 7577052 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577052", "IGV") low 0.131 3672 no call QD 876 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs672601296, TP53_g.13866C>G, TP53_g.13866C>T, TP53_g.13866C>A, TP53_g.13866del, COSM45306, COSM43915, COSM45069 tolerated(0.06) benign(0.052) not_provided 30 FFPE GTGGT G/A AGGCT CMDL150183 FLD0213 FLD0237 synonymous BRAF c.1800G>A c.1800G>A(p.%3D) gtG/gtA chr7 140453135 C T =hyperlink("http://localhost:60151/goto?locus=chr7:140453135", "IGV") medium 0.268 5419 no call pass 18955 BRAF_AA_HS ENSG00000157764 15 of 18 COSM1578949, COSM249890 9 FFPE GATTT C/T ACTGT CMDL150183 FLD0213 FLD0237 nonsynonymous EGFR c.2303G>A p.S768N aGc/aAc chr7 55249005 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249005", "IGV") medium 0.701 1670 no call pass 47479 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs121913465, COSM6241, COSM12989, COSM291998 deleterious(0.01) probably_damaging(0.999) pathogenic 85 FFPE GGCCA G/A CGTGG CMDL150183 FLD0213 FLD0237 nonsynonymous EGFR c.2327G>A p.R776H cGc/cAc chr7 55249029 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249029", "IGV") medium 0.695 1670 no call pass 46922 EGFR_E00001601336_1 24712396 ENSG00000146648 20 of 28 rs483352806, COSM22940 deleterious(0) probably_damaging(0.999) not_provided,drug_response 64 FFPE GTGCC G/A CCTGC CMDL150183 FLD0213 FLD0237 nonsynonymous EGFR c.2335G>A p.G779S Ggc/Agc chr7 55249037 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249037", "IGV") medium 0.694 1670 no call pass 28183 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs397517119, COSM22942, COSM25016 deleterious(0.03) probably_damaging(1) uncertain_significance 56 FFPE TGCTG G/A GCATC CMDL150183 FLD0213 FLD0237 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") medium 0.985 809 no call pass 33730 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150183 FLD0213 FLD0237 synonymous EGFR c.2343C>T c.2343C>T(p.%3D) tgC/tgT chr7 55249045 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249045", "IGV") medium 0.545 2403 pass no call 47961 EGFR_E00001601336_2 ENSG00000146648 20 of 28 24 FFPE ATCTG C/T CTCAC CMDL150183 FLD0213 FLD0237 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.994 0.995 2479 2086 pass pass 107004 92929 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150183 FLD0213 FLD0237 nonsynonymous EGFR c.2662C>T p.H888Y Cac/Tac chr7 55260495 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260495", "IGV") medium 0.684 2932 pass no call 45191 EGFR_E00001631695_1 ENSG00000146648 22 of 28 tolerated(0.74) possibly_damaging(0.455) 58 FFPE TTTTA C/T ACAGA CMDL150183 FLD0213 FLD0237 splice_region,intron EGFR c.2470-7G>A chr7 55259405 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259405", "IGV") medium 0.291 5226 pass no call 19690 EGFR_E00001681524_1 ENSG00000146648 20 of 27 34 FFPE TCTCT G/A TTTCA CMDL150183 FLD0213 FLD0237 nonsynonymous EGFR c.2474T>C p.M825T aTg/aCg chr7 55259416 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55259416", "IGV") low 0.193 5226 QD no call 8954 EGFR_E00001681524_1 ENSG00000146648 21 of 28 deleterious(0) probably_damaging(0.999) 45 FFPE GGGCA T/C GAACT CMDL150183 FLD0213 FLD0237 synonymous EGFR c.2505C>T c.2505C>T(p.%3D) caC/caT chr7 55259447 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259447", "IGV") medium 0.301 5226 pass no call 20487 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM3639751 76 FFPE GTGCA C/T CGCGA CMDL150183 FLD0213 FLD0237 nonsynonymous EGFR c.2515G>A p.A839T Gca/Aca chr7 55259457 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259457", "IGV") medium 0.247 4557 no call pass 11816 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM13430 deleterious(0) probably_damaging(0.993) 69 FFPE ACCTG G/A CAGCC CMDL150183 FLD0213 FLD0237 nonsynonymous EGFR c.2491C>T p.R831C Cgt/Tgt chr7 55259433 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259433", "IGV") medium 0.540 1702 pass no call 33979 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs371228501, COSM24846 deleterious(0.01) probably_damaging(0.997) uncertain_significance T:0.0002 17 FFPE AGGAC C/T GTCGC CMDL150183 FLD0213 FLD0237 nonsynonymous EGFR c.2575G>A p.A859T Gcc/Acc chr7 55259517 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259517", "IGV") low 0.159 2139 no call QD 1286 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM12675 deleterious(0) probably_damaging(0.999) 55 FFPE GGCTG G/A CCAAA CMDL150183 FLD0213 FLD0237 intron EGFR c.3115-47G>A chr7 55269381 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269381", "IGV") medium 0.317 4526 no call pass 20268 EGFR_E00001773562_1 ENSG00000146648 25 of 27 rs745729521 27 FFPE GATGA G/A ATGTG CMDL150183 FLD0213 FLD0237 intron EGFR c.3115-25G>A chr7 55269403 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269403", "IGV") low 0.189 4526 no call QD 8546 EGFR_E00001773562_1 ENSG00000146648 25 of 27 49 FFPE CCATG G/A GCAAC CMDL150183 FLD0213 FLD0237 intron EGFR c.3115-11T>C chr7 55269417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55269417", "IGV") low 0.169 4526 no call QD 2626 EGFR_E00001773562_1 ENSG00000146648 25 of 27 63 FFPE TCTGT T/C TCTTT CMDL150183 FLD0213 FLD0237 synonymous EGFR c.3141G>A c.3141G>A(p.%3D) gtG/gtA chr7 55269454 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269454", "IGV") low 0.189 4526 no call QD 5517 EGFR_E00001773562_1 ENSG00000146648 26 of 28 41 FFPE ACCGT G/A GCTTG CMDL150183 FLD0213 FLD0237 intron EGFR c.2702-23C>T chr7 55266387 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266387", "IGV") medium 0.545 2292 pass no call 33093 EGFR_E00001779947_1 ENSG00000146648 22 of 27 4 FFPE GCCTT C/T TTTTC CMDL150183 FLD0213 FLD0237 intron EGFR c.2702-15G>A chr7 55266395 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266395", "IGV") low 0.086 1603 no call QD 538 EGFR_E00001779947_1 ENSG00000146648 22 of 27 12 FFPE TTCTT G/A CTTCA CMDL150183 FLD0213 FLD0237 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.996 0.971 2299 1606 pass pass 96865 65504 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150183 FLD0213 FLD0237 nonsynonymous EGFR c.2726C>T p.T909I aCc/aTc chr7 55266434 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266434", "IGV") low 0.132 3244 no call QD 270 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(1) 51 FFPE GATGA C/T CTTTG CMDL150183 FLD0213 FLD0237 nonsynonymous EGFR c.2756C>T p.P919L cCt/cTt chr7 55266464 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266464", "IGV") medium 0.778 3244 no call pass 60616 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(0.994) 81 FFPE AATCC C/T TGCCA CMDL150183 FLD0213 FLD0237 synonymous EGFR c.2829C>T c.2829C>T(p.%3D) gtC/gtT chr7 55266537 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266537", "IGV") medium 0.578 4848 pass no call 56331 EGFR_E00001779947_2 ENSG00000146648 23 of 28 61 FFPE GATGT C/T TACAT CMDL150183 FLD0213 FLD0237 stop_gained EGFR c.2853G>A p.W951* tgG/tgA chr7 55268013 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268013", "IGV") medium 0.419 1459 no call pass 10257 EGFR_E00001790701_1 ENSG00000146648 24 of 28 55 FFPE GGCTG G/A ATGAT CMDL150183 FLD0213 FLD0237 nonsynonymous EGFR c.2918G>A p.R973Q cGa/cAa chr7 55268078 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268078", "IGV") medium 0.262 2212 pass no call 7045 EGFR_E00001790701_1 ENSG00000146648 24 of 28 rs756554871 deleterious(0.02) probably_damaging(0.992) 36 FFPE GGCCC G/A AGACC CMDL150183 FLD0213 FLD0237 synonymous EGFR c.2931C>T c.2931C>T(p.%3D) cgC/cgT chr7 55268091 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268091", "IGV") medium 0.473 723 no call pass 12207 EGFR_E00001790701_1 ENSG00000146648 24 of 28 23 FFPE CAGCG C/T TACCT CMDL150183 FLD0213 FLD0237 intron EGFR c.2947-27C>T chr7 55268854 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268854", "IGV") medium 0.634 5339 no call pass 70242 EGFR_E00001801208_1 ENSG00000146648 24 of 27 30 FFPE CCATT C/T TAATA CMDL150183 FLD0213 FLD0237 synonymous EGFR c.3024C>T c.3024C>T(p.%3D) gaC/gaT chr7 55268958 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268958", "IGV") medium 0.682 2163 pass no call 53906 EGFR_E00001801208_1 ENSG00000146648 25 of 28 rs747143752 10 FFPE ATGGA C/T GACGT CMDL150183 FLD0213 FLD0237 stop_gained EGFR c.3061C>T p.Q1021* Cag/Tag chr7 55268995 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268995", "IGV") medium 0.287 4936 no call pass 19745 EGFR_E00001801208_2 ENSG00000146648 25 of 28 57 FFPE CACAG C/T AGGGC CMDL150183 FLD0213 FLD0237 nonsynonymous EGFR c.3079C>T p.P1027S Ccc/Tcc chr7 55269013 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269013", "IGV") medium 0.378 4936 no call pass 40793 EGFR_E00001801208_2 ENSG00000146648 25 of 28 tolerated(0.09) probably_damaging(0.999) 66 FFPE GCAGC C/T CCTCC CMDL150183 FLD0213 FLD0237 nonsynonymous EGFR c.3100C>T p.L1034F Ctc/Ttc chr7 55269034 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269034", "IGV") medium 0.381 4936 no call pass 41857 EGFR_E00001801208_2 ENSG00000146648 25 of 28 rs764626121 tolerated(0.07) probably_damaging(0.999) 45 FFPE CTCCC C/T TCCTG CMDL150183 FLD0213 FLD0237 intron EGFR c.2185-15C>T chr7 55242400 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55242400", "IGV") low 0.139 5841 QD no call 42 EGFR_Exon19 ENSG00000146648 18 of 27 6 FFPE TCCTT C/T TCTCT CMDL150183 FLD0213 FLD0237 nonsynonymous EGFR c.2221C>T p.P741S Ccc/Tcc chr7 55242451 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55242451", "IGV") low 0.219 5841 QD no call 11119 EGFR_Exon19 ENSG00000146648 19 of 28 tolerated(0.07) probably_damaging(0.991) 57 FFPE AAATT C/T CCGTC CMDL150183 FLD0213 FLD0237 nonsynonymous EGFR c.2255C>T p.S752F tCt/tTt chr7 55242485 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55242485", "IGV") medium 0.669 4055 no call pass 57733 EGFR_Exon19 ENSG00000146648 19 of 28 rs121913464, COSM13186, COSM4170219 deleterious(0) probably_damaging(1) 33 FFPE AACAT C/T TCCGA CMDL150183 FLD0213 FLD0237 synonymous EGFR c.2265C>T c.2265C>T(p.%3D) gcC/gcT chr7 55242495 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55242495", "IGV") low 0.224 5841 QD no call 11208 EGFR_Exon19 ENSG00000146648 19 of 28 rs727503017, COSM18424 not_provided 23 FFPE AAAGC C/T AACAA CMDL150183 FLD0213 FLD0237 nonsynonymous TP53 c.82G>A p.E28K Gaa/Aaa chr17 7579714 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579714", "IGV") medium 0.295 101 no call pass 414 EXP0116_TP53_E3 ENSG00000141510 3 of 11 tolerated(0.74) benign(0.008) 21 FFPE GTTTT C/T AGGAA CMDL150183 FLD0213 FLD0237 splice_region,intron TP53 c.75-3C>T chr17 7579724 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579724", "IGV") low 0.136 59 QD no call 90 EXP0116_TP53_E3 ENSG00000141510 2 of 10 11 FFPE AGTCT G/A AAAGA CMDL150183 FLD0213 FLD0237 synonymous TP53 c.171C>T c.171C>T(p.%3D) gaC/gaT chr17 7579516 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579516", "IGV") medium 0.439 2672 no call pass 20622 EXP0116_TP53_E4 ENSG00000141510 4 of 11 rs587782776, COSM1741031, COSM1741032, COSM1741034, COSM1741033 uncertain_significance 20 FFPE CCTGG G/A TCTTC CMDL150183 FLD0213 FLD0237 stop_gained TP53 c.154C>T p.Q52* Caa/Taa chr17 7579533 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579533", "IGV") medium 0.392 4593 pass no call 31890 EXP0116_TP53_E4 ENSG00000141510 4 of 11 TP53_g.11385C>T, COSM44041, COSM99949, COSM99948, COSM3932748, COSM1750375 37 FFPE CCATT G/A TTCAA CMDL150183 FLD0213 FLD0237 synonymous KRAS c.67C>T c.67C>T(p.%3D) Cta/Tta chr12 25398252 G A =hyperlink("http://localhost:60151/goto?locus=chr12:25398252", "IGV") medium 0.962 3700 pass no call 100873 KRAS_AA_HS ENSG00000133703 2 of 6 COSM19907 58 FFPE AATTA G/A CTGTA CMDL150183 FLD0213 FLD0237 nonsynonymous KRAS c.35G>A p.G12D gGt/gAt chr12 25398284 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") medium 0.779 3700 pass no call 67934 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) benign(0.361) 26 FFPE CGCCA C/T CAGCT CMDL150183 FLD0213 FLD0237 splice_acceptor PIK3CA c.1540-2A>G chr3 178935996 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178935996", "IGV") low 0.095 62 QD no call 45 PIK3CA_Ex10_gap ENSG00000121879 9 of 20 32 FFPE TTTAC A/G GAGTA CMDL150183 FLD0213 FLD0237 synonymous PIK3CA c.1557A>G c.1557A>G(p.%3D) agA/agG chr3 178936015 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178936015", "IGV") medium 0.222 124 pass no call 333 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 51 FFPE GCTAG A/G GACAA CMDL150183 FLD0213 FLD0237 nonsynonymous PIK3CA c.3133G>A p.D1045N Gat/Aat chr3 178952078 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178952078", "IGV") medium 0.297 3958 no call pass 15063 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 COSM25086, COSM1421002 tolerated(0.17) benign(0.287) 21 FFPE TGAAT G/A ATGCA CMDL150183 FLD0213 FLD0237 nonsynonymous PIK3CA c.3193C>T p.H1065Y Cat/Tat chr3 178952138 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178952138", "IGV") low 0.166 5373 QD no call 2881 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 COSM6144, COSM1421031, COSM1421030 tolerated_low_confidence(0.14) benign(0.099) 70 FFPE AACAG C/T ATGCA CMDL150183 FLD0213 FLD0237 3_prime_UTR PIK3CA c.*4G>A chr3 178952156 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178952156", "IGV") medium 0.271 5373 pass no call 17195 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 52 FFPE GAAAA G/A ATAAC CMDL150183 FLD0213 FLD0237 3_prime_UTR PIK3CA c.*30C>T chr3 178952182 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178952182", "IGV") low 0.225 5373 QD no call 9732 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 26 FFPE TCACT C/T TGGAT CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.934G>A p.D312N Gac/Aac chr10 89720783 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720783", "IGV") medium 0.382 6813 pass no call 41870 PTEN_E00001156315_7 ENSG00000171862 8 of 9 tolerated(0.15) possibly_damaging(0.805) 51 FFPE ATAAT G/A ACAAG CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.949G>A p.V317I Gta/Ata chr10 89720798 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720798", "IGV") medium 0.247 6813 pass no call 21820 PTEN_E00001156315_7 ENSG00000171862 8 of 9 tolerated(0.68) benign(0.009) 66 FFPE ATCTA G/A TACTT CMDL150183 FLD0213 FLD0237 synonymous PTEN c.978C>T c.978C>T(p.%3D) gaC/gaT chr10 89720827 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720827", "IGV") medium 0.241 6448 no call pass 15712 PTEN_E00001156315_7 ENSG00000171862 8 of 9 69 FFPE CTTGA C/T AAAGC CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.991G>A p.D331N Gac/Aac chr10 89720840 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720840", "IGV") medium 0.258 6448 no call pass 20965 PTEN_E00001156315_7 ENSG00000171862 8 of 9 COSM1263304 deleterious(0.01) probably_damaging(1) 56 FFPE ATAAA G/A ACAAA CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.1016C>T p.P339L cCa/cTa chr10 89720865 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720865", "IGV") medium 0.147 3109 no call pass 7478 PTEN_E00001156315_7 ENSG00000171862 8 of 9 COSM5148 deleterious(0.02) probably_damaging(0.991) 31 FFPE TTCTC C/T AAATT CMDL150183 FLD0213 FLD0237 intron PTEN c.635-36C>T chr10 89717574 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717574", "IGV") medium 0.160 2415 no call pass 6900 PTEN_E00001156321_1 ENSG00000171862 6 of 8 4 FFPE ATTTC C/T TGTGA CMDL150183 FLD0213 FLD0237 splice_region,intron PTEN c.635-8C>T chr10 89717602 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717602", "IGV") low 0.213 5376 QD no call 8734 PTEN_E00001156321_1 ENSG00000171862 6 of 8 rs780495238 32 FFPE TTTAA C/T CATGC CMDL150183 FLD0213 FLD0237 synonymous PTEN c.663G>A c.663G>A(p.%3D) aaG/aaA chr10 89717638 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717638", "IGV") medium 0.235 4852 no call pass 10855 PTEN_E00001156321_1 ENSG00000171862 7 of 9 68 FFPE CTAAA G/A GTGAA CMDL150183 FLD0213 FLD0237 synonymous PTEN c.666G>A c.666G>A(p.%3D) gtG/gtA chr10 89717641 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717641", "IGV") low 0.180 5376 QD no call 4609 PTEN_E00001156321_1 ENSG00000171862 7 of 9 66 FFPE AAGGT G/A AAGAT CMDL150183 FLD0213 FLD0237 synonymous PTEN c.702G>A c.702G>A(p.%3D) cgG/cgA chr10 89717677 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717677", "IGV") medium 0.253 4310 pass no call 11072 PTEN_E00001156321_2 ENSG00000171862 7 of 9 38 FFPE CGACG G/A GAAGA CMDL150183 FLD0213 FLD0237 intron PTEN c.801+138G>A chr10 89717914 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717914", "IGV") low 0.129 1692 no call QD 2580 PTEN_E00001156321_4m ENSG00000171862 7 of 8 20 FFPE TTGGT G/A AGACA CMDL150183 FLD0213 FLD0237 intron PTEN c.493-47G>A chr10 89711828 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89711828", "IGV") medium 0.276 6390 pass no call 20145 PTEN_E00001156327_1 ENSG00000171862 5 of 8 33 FFPE ATAAT G/A GAACA CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.500C>T p.T167I aCt/aTt chr10 89711882 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711882", "IGV") low 0.187 6390 QD no call 6510 PTEN_E00001156327_1 ENSG00000171862 6 of 9 rs397514559, COSM35753, COSM35323 deleterious(0.02) possibly_damaging(0.742) pathogenic 36 FFPE AGTAA C/T TATTC CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.574G>A p.A192T Gca/Aca chr10 89711956 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89711956", "IGV") low 0.166 3125 QD no call 1559 PTEN_E00001156327_4 ENSG00000171862 6 of 9 COSM1492349 tolerated(1) benign(0.007) 48 FFPE CAGTG G/A CACTG CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.611C>T p.P204L cCa/cTa chr10 89711993 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711993", "IGV") medium 0.362 4565 no call pass 25378 PTEN_E00001156327_4 ENSG00000171862 6 of 9 COSM4165560, COSM1577256, COSM19563 deleterious(0.04) possibly_damaging(0.706) 57 FFPE TATTC C/T AATGT CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.626G>A p.G209E gGa/gAa chr10 89712008 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89712008", "IGV") low 0.147 3125 QD no call 286 PTEN_E00001156327_4 ENSG00000171862 6 of 9 deleterious(0) possibly_damaging(0.756) 42 FFPE TGGCG G/A AACTT CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.286C>T p.P96S Cca/Tca chr10 89692802 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692802", "IGV") medium 0.273 5617 pass no call 19498 PTEN_E00001156330_1 ENSG00000171862 5 of 9 rs398123320, COSM5120, COSM921086, COSM921085 deleterious(0.03) probably_damaging(0.919) uncertain_significance,pathogenic 35 FFPE ACCCA C/T CACAG CMDL150183 FLD0213 FLD0237 stop_gained PTEN c.328C>T p.Q110* Caa/Taa chr10 89692844 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692844", "IGV") medium 0.274 5617 pass no call 18462 PTEN_E00001156330_1 ENSG00000171862 5 of 9 CM971269, COSM5161, COSM1349508 55 FFPE TTGAC C/T AATGG CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.358G>A p.A120T Gca/Aca chr10 89692874 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692874", "IGV") low 0.163 5617 QD no call 3007 PTEN_E00001156330_1 ENSG00000171862 5 of 9 COSM1577255 deleterious(0) possibly_damaging(0.803) 25 FFPE ATGTT G/A CAGCA CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.371G>A p.C124Y tGt/tAt chr10 89692887 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692887", "IGV") low 0.206 5617 QD no call 8138 PTEN_E00001156330_1 ENSG00000171862 5 of 9 CM041823, CM110163, COSM5140, COSM5271 deleterious(0) probably_damaging(0.997) 12 FFPE TCACT G/A TAAAG CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.377C>T p.A126V gCt/gTt chr10 89692893 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692893", "IGV") medium 0.332 2412 no call pass 25399 PTEN_E00001156330_1 ENSG00000171862 5 of 9 COSM28884, COSM5041 deleterious(0.03) probably_damaging(0.965) 6 FFPE TAAAG C/T TGGAA CMDL150183 FLD0213 FLD0237 intron PTEN c.164+20C>T chr10 89653886 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653886", "IGV") medium 0.768 635 no call pass 10213 PTEN_E00001156351_1 ENSG00000171862 2 of 8 11 FFPE ATTTT C/T TATTT CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.1079G>A p.S360N aGc/aAc chr10 89725096 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725096", "IGV") medium 0.508 5016 pass no call 49517 PTEN_E00001456541_1 ENSG00000171862 9 of 9 tolerated(0.12) possibly_damaging(0.706) 65 FFPE GGCTA G/A CAGTT CMDL150183 FLD0213 FLD0237 synonymous PTEN c.1113C>T c.1113C>T(p.%3D) gaC/gaT chr10 89725130 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725130", "IGV") low 0.214 5016 QD no call 7420 PTEN_E00001456541_1 ENSG00000171862 9 of 9 COSM2156793 31 FFPE AGTGA C/T AATGA CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.1171C>T p.P391S Cct/Tct chr10 89725188 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725188", "IGV") medium 0.252 6086 pass no call 15002 PTEN_E00001456541_2 ENSG00000171862 9 of 9 tolerated_low_confidence(0.21) benign(0.108) 53 FFPE ATGAA C/T CTTTT CMDL150183 FLD0213 FLD0237 synonymous PTEN c.15C>T c.15C>T(p.%3D) atC/atT chr10 89624241 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624241", "IGV") medium 0.256 3049 pass no call 8704 PTEN_E00001456562_1 ENSG00000171862 1 of 9 47 FFPE ATCAT C/T AAAGA CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.19G>A p.E7K Gag/Aag chr10 89624245 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624245", "IGV") medium 0.232 4580 no call pass 9882 PTEN_E00001456562_1 ENSG00000171862 1 of 9 COSM5298 tolerated(0.8) benign(0.001) 51 FFPE TCAAA G/A AGATC CMDL150183 FLD0213 FLD0237 nonsynonymous PTEN c.44G>A p.R15K aGa/aAa chr10 89624270 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624270", "IGV") low 0.210 3049 QD no call 4865 PTEN_E00001456562_1 ENSG00000171862 1 of 9 rs398123324, COSM5232, COSM5064 deleterious(0) benign(0.102) uncertain_significance 76 FFPE AAGGA G/A ATATC CMDL150183 FLD0213 FLD0237 intron PTEN c.79+14C>T chr10 89624319 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624319", "IGV") low 0.208 3049 QD no call 4755 PTEN_E00001456562_1 ENSG00000171862 1 of 8 rs760610000 34 FFPE TTCTG C/T GGCTG CMDL150183 FLD0213 FLD0237 intron PTEN c.79+30C>T chr10 89624335 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624335", "IGV") medium 0.221 2245 no call pass 11999 PTEN_E00001456562_1 ENSG00000171862 1 of 8 rs750009848 18 FFPE CTTTA C/T CTTTC CMDL150183 FLD0213 FLD0237 intron TP53 c.993+230G>A chr17 7576623 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576623", "IGV") medium 0.537 4480 pass no call 48321 TP53_00001404886_13 ENSG00000141510 9 of 10 16 FFPE GCTCT C/T TTTAA CMDL150183 FLD0213 FLD0237 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 1.000 1.000 8 882 pass pass 281 36505 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150183 FLD0213 FLD0237 splice_donor TP53 c.672+2T>C chr17 7578175 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7578175", "IGV") medium 0.301 1748 no call pass 7437 TP53_E00001255919_1 ENSG00000141510 6 of 10 CS034998, CS0910926, TP53_g.12743T>G, TP53_g.12743T>C, TP53_g.12743T>A, COSM6907, COSM45517, COSM165066, COSM165068, COSM562642, COSM2744691, COSM562643, COSM165067, COSM2744693, COSM3773304, COSM3937610, COSM2744695, COSM1649396, COSM2744692, COSM165069, COSM2744694, COSM562644 66 FFPE ACCAG A/G CCTCA CMDL150183 FLD0213 FLD0237 nonsynonymous TP53 c.610G>A p.E204K Gag/Aag chr17 7578239 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578239", "IGV") low 0.750 14 pass no call 201 TP53_E00001255919_1 ENSG00000141510 6 of 11 TP53_g.12679del, TP53_g.12679G>A, TP53_g.12679G>C, TP53_g.12679G>T, COSM10804, COSM44011, COSM45782, COSM43990, COSM165087, COSM437512, COSM437513, COSM165086, COSM165088, COSM437515, COSM3362449, COSM1679501, COSM165089, COSM437514 tolerated(0.18) benign(0.152) 14 FFPE ATACT C/T CACAC CMDL150183 FLD0213 FLD0237 nonsynonymous TP53 c.587G>A p.R196Q cGa/cAa chr17 7578262 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578262", "IGV") low 0.134 3709 no call QD 91 TP53_E00001255919_3 ENSG00000141510 6 of 11 rs483352697, CM984587, TP53_g.12656del, TP53_g.12656G>A, TP53_g.12656G>C, TP53_g.12656G>T, COSM44599, COSM43814, COSM45444, COSM218533, COSM1386755, COSM218532, COSM1386756, COSM218534, COSM1386758, COSM3733288, COSM2744765, COSM218535, COSM1386757 tolerated(0.07) probably_damaging(0.997) 13 FFPE CCACT C/T GGATA CMDL150183 FLD0213 FLD0237 synonymous TP53 c.528C>T c.528C>T(p.%3D) tgC/tgT chr17 7578402 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578402", "IGV") medium 0.306 3684 pass no call 16907 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12516C>G, TP53_g.12516C>A, TP53_g.12516del, TP53_g.12516C>T, COSM44134, COSM11114, COSM43734, COSM179823, COSM1268357, COSM179822, COSM1268358, COSM179824, COSM1268360, COSM179825, COSM1268359 24 FFPE TGGGG G/A CAGCG CMDL150183 FLD0213 FLD0237 synonymous TP53 c.471C>T c.471C>T(p.%3D) gtC/gtT chr17 7578459 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578459", "IGV") low 0.214 4094 QD no call 7796 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12459C>A, TP53_g.12459C>T, COSM43934, COSM44526 15 FFPE GCGCG G/A ACGCG CMDL150183 FLD0213 FLD0237 synonymous TP53 c.429G>A c.429G>A(p.%3D) gtG/gtA chr17 7578501 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578501", "IGV") medium 0.311 4094 pass no call 19264 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12417G>C, TP53_g.12417del, TP53_g.12417G>A, TP53_g.12417G>T, COSM46087, COSM44902, COSM45780, COSM3958842, COSM3958845, COSM3958847, COSM3958844, COSM3958843, COSM3958846 57 FFPE AGCTG C/T ACAGG CMDL150183 FLD0213 FLD0237 synonymous TP53 c.409C>T c.409C>T(p.%3D) Ctg/Ttg chr17 7578521 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578521", "IGV") medium 0.210 4094 pass no call 12323 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12397C>T, TP53_g.12397C>G, TP53_g.12397del, TP53_g.12397C>A, COSM44182, COSM44696, COSM45058, COSM45834 53 FFPE GGCCA G/A TTGGC CMDL150183 FLD0213 FLD0237 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.991 0.994 1668 1030 pass pass 45208 34512 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150183 FLD0213 FLD0237 intron TP53 c.74+12C>T chr17 7579827 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579827", "IGV") medium 0.683 1030 no call pass 15268 TP53_E00001596491_1 ENSG00000141510 2 of 10 TP53_g.11091C>T, COSM45967 50 FFPE CCAAT G/A GATCC CMDL150183 FLD0213 FLD0237 intron TP53 c.375+11C>T chr17 7579301 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579301", "IGV") medium 0.281 5531 pass no call 20536 TP53_E00001612188_1 ENSG00000141510 4 of 10 22 FFPE CCTCA G/A GGCAA CMDL150183 FLD0213 FLD0237 nonsynonymous TP53 c.283T>C p.S95P Tct/Cct chr17 7579404 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7579404", "IGV") medium 0.236 3259 pass no call 7940 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11514T>A, COSM1386888, COSM1386889, COSM1386890 deleterious(0.01) probably_damaging(0.985) 27 FFPE AGAAG A/G TGACA CMDL150183 FLD0213 FLD0237 nonsynonymous TP53 c.229C>T p.P77S Cca/Tca chr17 7579458 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579458", "IGV") medium 0.275 3259 pass no call 11200 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs753085009, TP53_g.11460C>G, TP53_g.11460del, COSM44287, COSM46118 tolerated(0.45) benign(0.017) 43 FFPE TGCTG G/A TGCAG CMDL150183 FLD0213 FLD0237 nonsynonymous TP53 c.226G>A p.A76T Gca/Aca chr17 7579461 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579461", "IGV") medium 0.250 2171 no call pass 6223 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11457G>A tolerated(0.6) benign(0.005) 40 FFPE TGGTG C/T AGGGG CMDL150183 FLD0213 FLD0237 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.996 0.996 3259 2171 pass pass 119256 72779 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150183 FLD0213 FLD0237 intron TP53 c.782+20C>T chr17 7577479 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577479", "IGV") medium 0.320 1238 no call pass 11756 TP53_E00001665758_1 ENSG00000141510 7 of 10 30 FFPE TGCAG G/A GTGGC CMDL150183 FLD0213 FLD0237 synonymous TP53 c.759C>T c.759C>T(p.%3D) acC/acT chr17 7577522 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577522", "IGV") medium 0.241 3865 pass no call 10705 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13396C>T, TP53_g.13396del, TP53_g.13396C>G, COSM44843 73 FFPE ATGAT G/A GTGAG CMDL150183 FLD0213 FLD0237 nonsynonymous TP53 c.743G>A p.R248Q cGg/cAg chr17 7577538 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577538", "IGV") high 0.443 0.974 3865 2481 pass pass 32909 68030 TP53_E00001665758_1 25032700, 20377871, 18798306, 15450681, 25105660, 21264207 ENSG00000141510 7 of 11 rs11540652, CM920675, TP53_g.13380G>A, TP53_g.13380G>C, TP53_g.13380G>T, TP53_g.13380del, COSM10662, COSM11491, COSM6549, COSM46135, COSM340105, COSM99602, COSM241995, COSM99020, COSM241994, COSM340106, COSM3356964, COSM3378346, COSM1640830, COSM1646857, COSM1646858, COSM99021, COSM241996, COSM340107 deleterious(0) probably_damaging(1) pathogenic 74 FFPE GCCTC C/T GGTTC CMDL150183 FLD0213 FLD0237 synonymous TP53 c.1083G>A c.1083G>A(p.%3D) ggG/ggA chr17 7573944 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573944", "IGV") medium 0.817 3359 pass no call 66686 TP53_E00001728015_1 ENSG00000141510 10 of 11 TP53_g.16974del, TP53_g.16974G>A 64 FFPE CTGCT C/T CCCCC CMDL150183 FLD0213 FLD0237 nonsynonymous TP53 c.1025G>A p.R342Q cGa/cAa chr17 7574002 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7574002", "IGV") low 0.181 2928 no call QD 3081 TP53_E00001728015_1 ENSG00000141510 10 of 11 rs375338359, CM098494, TP53_g.16916G>T, TP53_g.16916G>A, TP53_g.16916del, TP53_g.16916G>C, COSM45278, COSM45276, COSM46154, COSM437468 tolerated(0.1) benign(0.034) 35 FFPE GCTCT C/T GGAAC CMDL150183 FLD0213 FLD0237 3_prime_UTR TP53 c.*34C>T chr17 7572893 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572893", "IGV") medium 0.439 2297 pass no call 18797 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs545818827 A:0.0002 24 FFPE GGTGG G/A AGGCT CMDL150183 FLD0213 FLD0237 intron TP53 c.993+25C>T chr17 7576828 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576828", "IGV") medium 0.314 2524 pass no call 22644 TP53_E00001789298_1 ENSG00000141510 9 of 10 22 FFPE CACTT G/A ATAAG CMDL150183 FLD0213 FLD0237 intron TP53 c.920-37G>A chr17 7576963 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576963", "IGV") low 0.150 4259 no call QD 1280 TP53_E00001789298_2 ENSG00000141510 8 of 10 38 FFPE TGAAT C/T TGAGG CMDL150183 FLD0213 FLD0237 intron TP53 c.919+32G>A chr17 7576987 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576987", "IGV") medium 0.286 4259 no call pass 21146 TP53_E00001789298_2 ENSG00000141510 8 of 10 TP53_g.13931G>A, TP53_g.13931G>T, COSM45455, COSM46127 62 FFPE TTGGT C/T TCCTC CMDL150183 FLD0213 FLD0237 intron TP53 c.919+30G>A chr17 7576989 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576989", "IGV") medium 0.288 4259 no call pass 21318 TP53_E00001789298_2 ENSG00000141510 8 of 10 64 FFPE GGTCT C/T CTCCA CMDL150183 FLD0213 FLD0237 synonymous TP53 c.873G>A c.873G>A(p.%3D) aaG/aaA chr17 7577065 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577065", "IGV") low 0.191 3677 no call QD 5278 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs372613518, TP53_g.13853G>T, TP53_g.13853del, TP53_g.13853G>A, TP53_g.13853G>C, COSM44446, COSM44874, COSM46224 43 FFPE CCTTT C/T TTGCG CMDL150183 FLD0213 FLD0237 nonsynonymous TP53 c.826G>A p.A276T Gcc/Acc chr17 7577112 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577112", "IGV") medium 0.446 3327 pass no call 56868 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13806G>C, TP53_g.13806G>A, TP53_g.13806del, TP53_g.13806G>T, COSM43663, COSM44114, COSM45467, COSM308313, COSM3937595, COSM3937594 tolerated(0.1) probably_damaging(0.985) 55 FFPE ACAGG C/T ACAAA CMDL150183 FLD0213 FLD0237 nonsynonymous TP53 c.824G>A p.C275Y tGt/tAt chr17 7577114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577114", "IGV") medium 0.446 3327 pass no call 56868 TP53_E00001789298_3 ENSG00000141510 8 of 11 CM951234, CM076568, TP53_g.13804G>A, TP53_g.13804del, TP53_g.13804G>C, TP53_g.13804G>T, COSM10701, COSM10893, COSM45413, COSM44178, COSM165084, COSM99932, COSM1167915, COSM318164, COSM3403255, COSM3723938, COSM1637959, COSM2744531, COSM1728541 deleterious(0) probably_damaging(0.994) 53 FFPE AGGCA C/T AAACA CMDL150183 FLD0213 FLD0237 synonymous TP53 c.813G>A c.813G>A(p.%3D) gaG/gaA chr17 7577125 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577125", "IGV") medium 0.443 3327 pass no call 31889 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13793G>A, TP53_g.13793G>C, TP53_g.13793G>T, COSM44617, COSM44441, COSM45284 42 FFPE CGCAC C/T TCAAA CMDL150183 FLD0213 FLD0237 synonymous TP53 c.793C>T c.793C>T(p.%3D) Ctg/Ttg chr17 7577145 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577145", "IGV") low 0.194 3327 QD no call 5272 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13773C>A, TP53_g.13773C>T, TP53_g.13773del, COSM44984, COSM45393, COSM44293, COSM3388177, COSM3388179, COSM3388178 22 FFPE TCCCA G/A TAGAT CMDL150183 FLD0213 FLD0237 splice_acceptor TP53 c.783-2A>G chr17 7577157 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7577157", "IGV") medium 0.223 1898 no call pass 11209 TP53_E00001789298_3 ENSG00000141510 7 of 10 TP53_g.13761A>C, TP53_g.13761A>T, TP53_g.13761A>G, COSM45956, COSM45132, COSM13744, COSM2744551, COSM1230105, COSM3970347, COSM2744552 10 FFPE ACCAC T/C ACTCA CMDL150184 FLD0214 FLD0238 nonsynonymous BRAF c.1792G>A p.A598T Gct/Act chr7 140453143 C T =hyperlink("http://localhost:60151/goto?locus=chr7:140453143", "IGV") low 0.150 5668 no call QD 1829 BRAF_AA_HS ENSG00000157764 15 of 18 COSM28505 deleterious(0) possibly_damaging(0.822) 17 FFPE TGTAG C/T TAGAC CMDL150184 FLD0214 FLD0238 nonsynonymous BRAF c.1787G>A p.G596D gGt/gAt chr7 140453148 C T =hyperlink("http://localhost:60151/goto?locus=chr7:140453148", "IGV") low 0.160 7176 QD no call 3561 BRAF_AA_HS ENSG00000157764 15 of 18 CM060877, rs397507483, COSM26506 deleterious(0) probably_damaging(0.988) pathogenic 22 FFPE CTAGA C/T CAAAA CMDL150184 FLD0214 FLD0238 synonymous BRAF c.1764C>T c.1764C>T(p.%3D) ctC/ctT chr7 140453171 G A =hyperlink("http://localhost:60151/goto?locus=chr7:140453171", "IGV") low 0.182 7176 QD no call 9550 BRAF_AA_HS ENSG00000157764 15 of 18 COSM1568585 45 FFPE ACTGT G/A AGGTC CMDL150184 FLD0214 FLD0238 nonsynonymous BRAF c.1750C>T p.L584F Ctt/Ttt chr7 140453185 G A =hyperlink("http://localhost:60151/goto?locus=chr7:140453185", "IGV") medium 0.254 7176 pass no call 27370 BRAF_AA_HS ENSG00000157764 15 of 18 COSM28010 deleterious(0.01) probably_damaging(0.968) 49 FFPE ATGAA G/A AAATA CMDL150184 FLD0214 FLD0238 splice_acceptor BRAF c.1742-1G>A chr7 140453194 C T =hyperlink("http://localhost:60151/goto?locus=chr7:140453194", "IGV") medium 0.283 5668 no call pass 22329 BRAF_AA_HS ENSG00000157764 14 of 17 COSM1686552 40 FFPE TATAT C/T TGAGG CMDL150184 FLD0214 FLD0238 splice_region,intron BRAF c.1742-5C>T chr7 140453198 G A =hyperlink("http://localhost:60151/goto?locus=chr7:140453198", "IGV") medium 0.252 7176 pass no call 26535 BRAF_AA_HS ENSG00000157764 14 of 17 36 FFPE TCTGA G/A GTGTA CMDL150184 FLD0214 FLD0238 synonymous EGFR c.2388C>T c.2388C>T(p.%3D) ggC/ggT chr7 55249090 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249090", "IGV") medium 0.354 3948 no call pass 22930 EGFR_E00001601336_2 ENSG00000146648 20 of 28 69 FFPE TTCGG C/T TGCCT CMDL150184 FLD0214 FLD0238 stop_gained EGFR c.2450G>A p.W817* tGg/tAg chr7 55249152 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249152", "IGV") medium 0.487 4909 pass no call 44331 EGFR_E00001601336_2 ENSG00000146648 20 of 28 43 FFPE CAACT G/A GTGTG CMDL150184 FLD0214 FLD0238 nonsynonymous EGFR c.2465C>T p.A822V gCa/gTa chr7 55249167 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249167", "IGV") medium 0.358 2020 no call pass 22464 EGFR_E00001601336_2 ENSG00000146648 20 of 28 deleterious(0) possibly_damaging(0.85) 28 FFPE GATCG C/T AAAGG CMDL150184 FLD0214 FLD0238 intron EGFR c.2470-27C>T chr7 55259385 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259385", "IGV") medium 0.973 2819 pass no call 116594 EGFR_E00001681524_1 ENSG00000146648 20 of 27 14 FFPE TGTCC C/T TCACA CMDL150184 FLD0214 FLD0238 synonymous EGFR c.2478C>T c.2478C>T(p.%3D) aaC/aaT chr7 55259420 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259420", "IGV") medium 0.972 5641 pass no call 151876 EGFR_E00001681524_1 ENSG00000146648 21 of 28 49 FFPE ATGAA C/T TACTT CMDL150184 FLD0214 FLD0238 nonsynonymous EGFR c.2507G>A p.R836H cGc/cAc chr7 55259449 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259449", "IGV") medium 0.993 1991 no call pass 60499 EGFR_E00001681524_1 ENSG00000146648 21 of 28 rs146121458, COSM133566 deleterious(0) probably_damaging(0.997) 77 FFPE GCACC G/A CGACC CMDL150184 FLD0214 FLD0238 synonymous EGFR c.2574G>A c.2574G>A(p.%3D) ctG/ctA chr7 55259516 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259516", "IGV") medium 0.175 1112 no call pass 4220 EGFR_E00001681524_1 ENSG00000146648 21 of 28 rs397517129, COSM133590 uncertain_significance 10 FFPE GGGCT G/A GCCAA CMDL150184 FLD0214 FLD0238 nonsynonymous EGFR c.2506C>T p.R836C Cgc/Tgc chr7 55259448 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259448", "IGV") low 0.203 4079 QD no call 6301 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs374952732, COSM53227, COSM28604 deleterious(0) probably_damaging(0.999) 32 FFPE TGCAC C/T GCGAC CMDL150184 FLD0214 FLD0238 synonymous EGFR c.2535G>A c.2535G>A(p.%3D) gtG/gtA chr7 55259477 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259477", "IGV") low 0.137 4079 QD no call 259 EGFR_E00001681524_2 ENSG00000146648 21 of 28 61 FFPE CTGGT G/A AAAAC CMDL150184 FLD0214 FLD0238 nonsynonymous EGFR c.3143C>T p.A1048V gCt/gTt chr7 55269456 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269456", "IGV") medium 0.422 4325 no call pass 31915 EGFR_E00001773562_1 ENSG00000146648 26 of 28 rs78244461, COSM18445 tolerated(0.28) benign(0.002) T:0.0010 39 FFPE CGTGG C/T TTGCA CMDL150184 FLD0214 FLD0238 intron EGFR c.2702-11C>T chr7 55266399 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266399", "IGV") medium 0.343 1733 pass no call 19340 EGFR_E00001779947_1 ENSG00000146648 22 of 27 16 FFPE TGCTT C/T ATCCT CMDL150184 FLD0214 FLD0238 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.996 0.998 1736 1170 pass pass 73127 49739 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150184 FLD0214 FLD0238 nonsynonymous EGFR c.2800C>T p.P934S Cct/Tct chr7 55266508 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266508", "IGV") medium 0.337 3486 pass no call 16983 EGFR_E00001779947_1 ENSG00000146648 23 of 28 rs575565383, COSM3923814 deleterious(0.03) probably_damaging(1) T:0.0004 44 FFPE GCCTC C/T CTCAG CMDL150184 FLD0214 FLD0238 intron EGFR c.2848+11G>A chr7 55266567 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266567", "IGV") low 0.186 4838 no call QD 5309 EGFR_E00001779947_2 ENSG00000146648 23 of 27 57 FFPE TGACT G/A GTGGG CMDL150184 FLD0214 FLD0238 intron EGFR c.2848+27C>T chr7 55266583 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266583", "IGV") medium 0.343 6230 pass no call 33172 EGFR_E00001779947_2 ENSG00000146648 23 of 27 41 FFPE CCACA C/T TGCCT CMDL150184 FLD0214 FLD0238 intron EGFR c.2849-25C>T chr7 55267984 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55267984", "IGV") low 0.125 1893 no call QD 1652 EGFR_E00001790701_1 ENSG00000146648 23 of 27 26 FFPE TTGCA C/T TGTTT CMDL150184 FLD0214 FLD0238 synonymous EGFR c.3018C>T c.3018C>T(p.%3D) gaC/gaT chr7 55268952 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268952", "IGV") medium 0.569 4903 no call pass 65812 EGFR_E00001801208_2 ENSG00000146648 25 of 28 14 FFPE GAAGA C/T ATGGA CMDL150184 FLD0214 FLD0238 synonymous EGFR c.3027C>T c.3027C>T(p.%3D) gaC/gaT chr7 55268961 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268961", "IGV") medium 0.210 4967 no call pass 13605 EGFR_E00001801208_2 ENSG00000146648 25 of 28 rs754193639 23 FFPE GACGA C/T GTGGT CMDL150184 FLD0214 FLD0238 synonymous EGFR c.3033G>A c.3033G>A(p.%3D) gtG/gtA chr7 55268967 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268967", "IGV") medium 0.241 5827 pass no call 20507 EGFR_E00001801208_2 ENSG00000146648 25 of 28 29 FFPE GTGGT G/A GATGC CMDL150184 FLD0214 FLD0238 nonsynonymous EGFR c.3034G>A p.D1012N Gat/Aat chr7 55268968 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268968", "IGV") medium 0.240 5827 pass no call 20523 EGFR_E00001801208_2 ENSG00000146648 25 of 28 COSM27096 deleterious(0.03) probably_damaging(0.991) 30 FFPE TGGTG G/A ATGCC CMDL150184 FLD0214 FLD0238 synonymous EGFR c.3087G>A c.3087G>A(p.%3D) acG/acA chr7 55269021 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269021", "IGV") medium 0.242 5827 pass no call 14314 EGFR_E00001801208_2 ENSG00000146648 25 of 28 rs141489713 A:0.0002 58 FFPE TCCAC G/A TCACG CMDL150184 FLD0214 FLD0238 nonsynonymous EGFR c.2252C>T p.T751I aCa/aTa chr7 55242482 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55242482", "IGV") low 0.152 6411 no call QD 2789 EGFR_Exon19 ENSG00000146648 19 of 28 rs727504316, COSM13185 deleterious(0) probably_damaging(0.987) drug_response 36 FFPE AGCAA C/T ATCTC CMDL150184 FLD0214 FLD0238 synonymous EGFR c.2271G>A c.2271G>A(p.%3D) aaG/aaA chr7 55242501 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55242501", "IGV") low 0.151 6411 no call QD 2341 EGFR_Exon19 ENSG00000146648 19 of 28 17 FFPE AACAA G/A GAAAT CMDL150184 FLD0214 FLD0238 intron TP53 c.96+11G>A chr17 7579689 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579689", "IGV") medium 0.654 172 pass no call 2593 EXP0116_TP53_E3 ENSG00000141510 3 of 10 46 FFPE CAACC C/T TTGTC CMDL150184 FLD0214 FLD0238 stop_gained TP53 c.112C>T p.Q38* Caa/Taa chr17 7579575 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579575", "IGV") medium 0.458 3728 no call pass 31893 EXP0116_TP53_E4 ENSG00000141510 4 of 11 CM107390, TP53_g.11343C>T, TP53_g.11343del, COSM46286, COSM236890, COSM236889 32 FFPE TGCTT G/A GGACG CMDL150184 FLD0214 FLD0238 intron KRAS c.111+10G>A chr12 25398198 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398198", "IGV") medium 0.297 5253 no call pass 22121 KRAS_AA_HS ENSG00000133703 2 of 5 rs755397559 15 FFPE TAAAA C/T AAGAT CMDL150184 FLD0214 FLD0238 splice_region,intron KRAS c.111+6T>C chr12 25398202 A G =hyperlink("http://localhost:60151/goto?locus=chr12:25398202", "IGV") medium 0.337 6197 pass no call 31602 KRAS_AA_HS ENSG00000133703 2 of 5 rs748695743 19 FFPE ACAAG A/G TTTAC CMDL150184 FLD0214 FLD0238 nonsynonymous KRAS c.101C>T p.P34L cCa/cTa chr12 25398218 G A =hyperlink("http://localhost:60151/goto?locus=chr12:25398218", "IGV") medium 0.235 6197 pass no call 15581 KRAS_AA_HS ENSG00000133703 2 of 6 CM070968, CM070967, rs104894366, CM061081, COSM1168054, COSM1360859 deleterious(0) probably_damaging(0.995) pathogenic 35 FFPE TTGTT G/A GATCA CMDL150184 FLD0214 FLD0238 nonsynonymous PIK3CA c.1618C>T p.L540F Ctc/Ttc chr3 178936076 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178936076", "IGV") medium 0.990 1349 pass no call 38914 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM219115 deleterious(0.01) probably_damaging(0.998) 51 FFPE ATCCT C/T TCTCT CMDL150184 FLD0214 FLD0238 stop_retained PIK3CA c.3206G>A c.3206G>A(p.%3D) tGa/tAa chr3 178952151 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178952151", "IGV") low 0.179 7216 QD no call 6380 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 57 FFPE GAACT G/A AAAAG CMDL150184 FLD0214 FLD0238 intron PTEN c.802-29C>T chr10 89720622 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720622", "IGV") low 0.456 92 no call pass 690 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs759473017, COSM5917 63 FFPE CATTT C/T TTTTT CMDL150184 FLD0214 FLD0238 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.008 92 no call QD 70 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150184 FLD0214 FLD0238 nonsynonymous PTEN c.940G>A p.E314K Gaa/Aaa chr10 89720789 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720789", "IGV") medium 0.340 7445 pass no call 45604 PTEN_E00001156315_7 ENSG00000171862 8 of 9 COSM5305, COSM5081 tolerated(0.41) benign(0.174) 57 FFPE ACAAG G/A AATAT CMDL150184 FLD0214 FLD0238 nonsynonymous PTEN c.949G>A p.V317I Gta/Ata chr10 89720798 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720798", "IGV") medium 0.343 7445 pass no call 46158 PTEN_E00001156315_7 ENSG00000171862 8 of 9 tolerated(0.68) benign(0.009) 66 FFPE ATCTA G/A TACTT CMDL150184 FLD0214 FLD0238 nonsynonymous PTEN c.991G>A p.D331N Gac/Aac chr10 89720840 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720840", "IGV") medium 0.273 6424 no call pass 19873 PTEN_E00001156315_7 ENSG00000171862 8 of 9 COSM1263304 deleterious(0.01) probably_damaging(1) 56 FFPE ATAAA G/A ACAAA CMDL150184 FLD0214 FLD0238 intron PTEN c.801+23G>A chr10 89717799 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717799", "IGV") medium 0.251 1433 no call pass 10052 PTEN_E00001156321_4m ENSG00000171862 7 of 8 rs116160352 benign A:0.0008 30 FFPE ATTGG G/A AGAAA CMDL150184 FLD0214 FLD0238 splice_region,intron PTEN c.493-3C>T chr10 89711872 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711872", "IGV") medium 0.323 5785 no call pass 26506 PTEN_E00001156327_1 ENSG00000171862 5 of 8 46 FFPE TCCAC C/T AGGGA CMDL150184 FLD0214 FLD0238 synonymous PTEN c.282C>T c.282C>T(p.%3D) aaC/aaT chr10 89692798 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692798", "IGV") medium 0.272 5175 pass no call 18263 PTEN_E00001156330_1 ENSG00000171862 5 of 9 COSM921084 31 FFPE CATAA C/T CCACC CMDL150184 FLD0214 FLD0238 nonsynonymous PTEN c.283C>T p.P95S Cca/Tca chr10 89692799 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692799", "IGV") low 0.129 5175 QD no call 197 PTEN_E00001156330_1 ENSG00000171862 5 of 9 COSM5136 deleterious(0.03) possibly_damaging(0.461) 32 FFPE ATAAC C/T CACCA CMDL150184 FLD0214 FLD0238 synonymous PTEN c.292C>T c.292C>T(p.%3D) Cta/Tta chr10 89692808 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692808", "IGV") low 0.182 5175 QD no call 5075 PTEN_E00001156330_1 ENSG00000171862 5 of 9 41 FFPE CACAG C/T TAGAA CMDL150184 FLD0214 FLD0238 nonsynonymous PTEN c.322C>T p.L108F Ctt/Ttt chr10 89692838 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692838", "IGV") medium 0.127 5175 pass no call 12480 PTEN_E00001156330_1 ENSG00000171862 5 of 9 deleterious(0.01) possibly_damaging(0.889) 61 FFPE AAGAT C/T TTGAC CMDL150184 FLD0214 FLD0238 synonymous PTEN c.327C>T c.327C>T(p.%3D) gaC/gaT chr10 89692843 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692843", "IGV") medium 0.129 5175 pass no call 12480 PTEN_E00001156330_1 ENSG00000171862 5 of 9 rs763477642 56 FFPE CTTGA C/T CAATG CMDL150184 FLD0214 FLD0238 nonsynonymous PTEN c.355G>A p.V119I Gtt/Att chr10 89692871 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692871", "IGV") medium 0.585 2826 no call pass 33887 PTEN_E00001156330_1 ENSG00000171862 5 of 9 CM001318, rs139767111, COSM39406, COSM28903, COSM1349516 tolerated(0.09) possibly_damaging(0.865) 28 FFPE ATCAT G/A TTGCA CMDL150184 FLD0214 FLD0238 nonsynonymous PTEN c.376G>A p.A126T Gct/Act chr10 89692892 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692892", "IGV") low 0.113 2572 QD no call 2697 PTEN_E00001156330_1 ENSG00000171862 5 of 9 CM110132, COSM5211, COSM28889, COSM5051 deleterious(0) probably_damaging(0.995) 7 FFPE GTAAA G/A CTGGA CMDL150184 FLD0214 FLD0238 nonsynonymous PTEN c.398T>C p.V133A gTa/gCa chr10 89692914 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89692914", "IGV") low 0.152 556 no call QD 351 PTEN_E00001156330_3 ENSG00000171862 5 of 9 deleterious(0.01) possibly_damaging(0.714) 51 FFPE TGGTG T/C AATGA CMDL150184 FLD0214 FLD0238 nonsynonymous PTEN c.428G>A p.G143D gGc/gAc chr10 89692944 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692944", "IGV") low 0.073 556 no call QD 117 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM28894 tolerated(0.22) benign(0.072) 81 FFPE TCGGG G/A CAAAT CMDL150184 FLD0214 FLD0238 nonsynonymous PTEN c.442G>A p.A148T Gca/Aca chr10 89692958 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692958", "IGV") low 0.075 556 no call QD 117 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5071, COSM1561206 tolerated(0.06) benign(0.394) 67 FFPE TAAAG G/A CACAA CMDL150184 FLD0214 FLD0238 synonymous PTEN c.189C>T c.189C>T(p.%3D) aaC/aaT chr10 89685294 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89685294", "IGV") low 0.188 1231 no call QD 1758 PTEN_E00001156344_1 ENSG00000171862 3 of 9 45 FFPE AAAAA C/T CATTA CMDL150184 FLD0214 FLD0238 nonsynonymous PTEN c.59G>A p.G20E gGa/gAa chr10 89624285 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624285", "IGV") medium 0.698 4855 pass no call 75731 PTEN_E00001456562_1 ENSG00000171862 1 of 9 COSM5094 deleterious(0.03) benign(0.141) 68 FFPE GGATG G/A ATTCG CMDL150184 FLD0214 FLD0238 intron TP53 c.993+176C>T chr17 7576677 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576677", "IGV") low 0.171 5726 QD no call 4872 TP53_00001404886_13 ENSG00000141510 9 of 10 38 FFPE TTATG G/A TATAA CMDL150184 FLD0214 FLD0238 intron TP53 c.672+10G>A chr17 7578167 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578167", "IGV") medium 0.376 4084 pass no call 25960 TP53_E00001255919_1 ENSG00000141510 6 of 10 58 FFPE AGTTG C/T AAACC CMDL150184 FLD0214 FLD0238 intron TP53 c.560-37G>A chr17 7578326 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578326", "IGV") low 0.206 5572 QD no call 8950 TP53_E00001255919_3 ENSG00000141510 5 of 10 64 FFPE GGGGA C/T CCTGG CMDL150184 FLD0214 FLD0238 nonsynonymous TP53 c.412G>A p.A138T Gcc/Acc chr17 7578518 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578518", "IGV") medium 0.236 4911 pass no call 12499 TP53_E00001255919_6 25105660 ENSG00000141510 5 of 11 CM942116, rs28934875, CM983475, TP53_g.12400G>C, TP53_g.12400G>T, TP53_g.12400del, TP53_g.12400G>A, COSM44821, COSM44280, COSM11188, COSM44508, COSM129860, COSM3403284, COSM3403287, COSM129861, COSM129863, COSM3403289, COSM4139889, COSM3403286, COSM2744944, COSM3403285, COSM3403288, COSM129862 deleterious(0) probably_damaging(0.979) pathogenic 56 FFPE CTTGG C/T CAGTT CMDL150184 FLD0214 FLD0238 synonymous TP53 c.390C>T c.390C>T(p.%3D) ctC/ctT chr17 7578540 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578540", "IGV") low 0.160 3431 no call QD 2149 TP53_E00001255919_6 ENSG00000141510 5 of 11 rs781537596, TP53_g.12378C>T, TP53_g.12378C>G, COSM45077 likely_benign 34 FFPE TTGTT G/A AGGGC CMDL150184 FLD0214 FLD0238 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.996 0.995 1697 1842 pass pass 45734 51222 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150184 FLD0214 FLD0238 nonsynonymous TP53 c.11C>T p.P4L cCg/cTg chr17 7579902 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579902", "IGV") medium 0.629 1704 pass no call 22576 TP53_E00001596491_1 ENSG00000141510 2 of 11 tolerated(0.06) benign(0.004) 21 FFPE ACTGC G/A GCTCC CMDL150184 FLD0214 FLD0238 stop_gained TP53 c.310C>T p.Q104* Cag/Tag chr17 7579377 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579377", "IGV") low 0.118 5825 QD no call 493 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11541C>T, TP53_g.11541del, COSM10886, COSM308172, COSM308171, COSM3727867, COSM2745029 29 FFPE GCCCT G/A GTAGG CMDL150184 FLD0214 FLD0238 nonsynonymous TP53 c.232G>A p.A78T Gca/Aca chr17 7579455 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579455", "IGV") low 0.127 2043 no call LowQual,QD 16 TP53_E00001612188_2 ENSG00000141510 4 of 11 COSM219129 tolerated(0.55) benign(0.004) 46 FFPE AGCTG C/T TGGTG CMDL150184 FLD0214 FLD0238 synonymous TP53 c.216C>T c.216C>T(p.%3D) ccC/ccT chr17 7579471 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579471", "IGV") low 0.140 2043 no call QD 704 TP53_E00001612188_2 ENSG00000141510 4 of 11 COSM18569, COSM1268331, COSM1268332 30 FFPE GCCAC G/A GGGGG CMDL150184 FLD0214 FLD0238 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.994 0.993 2899 2043 pass pass 106957 71325 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150184 FLD0214 FLD0238 nonsynonymous TP53 c.208G>A p.A70T Gct/Act chr17 7579479 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579479", "IGV") medium 0.348 2899 pass no call 15875 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11439G>A, COSM44736 tolerated(0.6) benign(0.002) 22 FFPE GGGAG C/T AGCCT CMDL150184 FLD0214 FLD0238 nonsynonymous TP53 c.200C>T p.P67L cCa/cTa chr17 7579487 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579487", "IGV") low 0.150 0.190 2899 2043 QD QD 2029 3289 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11431C>G, TP53_g.11431C>T, COSM46097, COSM44939 tolerated(0.74) benign(0.002) 14 FFPE CCTCT G/A GCATT CMDL150184 FLD0214 FLD0238 nonsynonymous TP53 c.199C>T p.P67S Cca/Tca chr17 7579488 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579488", "IGV") low 0.131 2043 no call QD 51 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11430C>T, TP53_g.11430del, COSM44199, COSM46345 tolerated(0.64) benign(0.001) 13 FFPE CTCTG G/A CATTC CMDL150184 FLD0214 FLD0238 nonsynonymous TP53 c.743G>A p.R248Q cGg/cAg chr17 7577538 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577538", "IGV") high 0.995 0.991 3062 2762 pass pass 95806 76450 TP53_E00001665758_1 25032700, 20377871, 18798306, 15450681, 25105660, 21264207 ENSG00000141510 7 of 11 rs11540652, CM920675, TP53_g.13380G>A, TP53_g.13380G>C, TP53_g.13380G>T, TP53_g.13380del, COSM10662, COSM11491, COSM6549, COSM46135, COSM340105, COSM99602, COSM241995, COSM99020, COSM241994, COSM340106, COSM3356964, COSM3378346, COSM1640830, COSM1646857, COSM1646858, COSM99021, COSM241996, COSM340107 deleterious(0) probably_damaging(1) pathogenic 74 FFPE GCCTC C/T GGTTC CMDL150184 FLD0214 FLD0238 synonymous TP53 c.1002G>A c.1002G>A(p.%3D) ggG/ggA chr17 7574025 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7574025", "IGV") medium 0.187 269 pass no call 1197 TP53_E00001728015_1 ENSG00000141510 10 of 11 12 FFPE TCACG C/T CCACG CMDL150184 FLD0214 FLD0238 nonsynonymous TP53 c.998G>A p.R333H cGt/cAt chr17 7574029 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7574029", "IGV") medium 0.908 269 pass no call 9577 TP53_E00001728015_1 ENSG00000141510 10 of 11 rs573154688 tolerated(0.19) benign(0.178) uncertain_significance T:0.0002 8 FFPE GCCCA C/T GGATC CMDL150184 FLD0214 FLD0238 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.520 3869 pass no call 39269 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150184 FLD0214 FLD0238 intron TP53 c.920-11C>T chr17 7576937 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576937", "IGV") medium 0.760 1220 no call pass 37338 TP53_E00001789298_1 ENSG00000141510 8 of 10 27 FFPE AAAGA G/A GCAAG CMDL150184 FLD0214 FLD0238 intron TP53 c.920-12C>T chr17 7576938 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576938", "IGV") medium 0.324 4831 no call pass 23251 TP53_E00001789298_2 ENSG00000141510 8 of 10 13 FFPE AAGAG G/A CAAGG CMDL150184 FLD0214 FLD0238 splice_donor TP53 c.919+1G>A chr17 7577018 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577018", "IGV") medium 0.247 5855 pass no call 15566 TP53_E00001789298_2 ENSG00000141510 8 of 10 CD920913, CS107068, TP53_g.13900G>A, TP53_g.13900G>T, TP53_g.13900G>C, COSM44143, COSM13585, COSM13584, COSM97868, COSM213111, COSM1230104, COSM2744491, COSM3378338, COSM3378337, COSM2744494, COSM2744492 38 FFPE GCTTA C/T CTCGC CMDL150184 FLD0214 FLD0238 nonsynonymous TP53 c.826G>A p.A276T Gcc/Acc chr17 7577112 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577112", "IGV") medium 0.828 3198 no call pass 66793 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13806G>C, TP53_g.13806G>A, TP53_g.13806del, TP53_g.13806G>T, COSM43663, COSM44114, COSM45467, COSM308313, COSM3937595, COSM3937594 tolerated(0.1) probably_damaging(0.985) 55 FFPE ACAGG C/T ACAAA CMDL150184 FLD0214 FLD0238 nonsynonymous TP53 c.818G>A p.R273H cGt/cAt chr17 7577120 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577120", "IGV") medium 0.827 3198 no call pass 66502 TP53_E00001789298_3 25105660 ENSG00000141510 8 of 11 CM920677, CM010472, rs28934576, CM004342, TP53_g.13798G>C, TP53_g.13798del, TP53_g.13798G>A, TP53_g.13798G>T, COSM10660, COSM43896, COSM44440, COSM10779, COSM318169, COSM99729, COSM165077, COSM3356963, COSM3675521, COSM1640828, COSM1645335, COSM1646808 tolerated(0.13) possibly_damaging(0.631) pathogenic T:0.0002 47 FFPE AAACA C/T GCACC CMDL150184 FLD0214 FLD0238 synonymous TP53 c.801G>A c.801G>A(p.%3D) cgG/cgA chr17 7577137 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577137", "IGV") medium 0.829 3198 no call pass 66644 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13781G>T, TP53_g.13781G>C, TP53_g.13781G>A, TP53_g.13781del, COSM44362, COSM44635, COSM45706, COSM44021, COSM1630411 30 FFPE CTGTT C/T CGTCC CMDL150199 FLD0215 FLD0239 synonymous BRAF c.1761C>T c.1761C>T(p.%3D) gaC/gaT chr7 140453174 G A =hyperlink("http://localhost:60151/goto?locus=chr7:140453174", "IGV") medium 0.350 5714 no call pass 31506 BRAF_AA_HS ENSG00000157764 15 of 18 rs121913336, COSM465, COSM21609 48 FFPE GTGAG G/A TCTTC CMDL150199 FLD0215 FLD0239 splice_region,intron BRAF c.1742-6C>T chr7 140453199 G A =hyperlink("http://localhost:60151/goto?locus=chr7:140453199", "IGV") medium 0.189 3470 pass no call 7484 BRAF_AA_HS ENSG00000157764 14 of 17 rs772966582 35 FFPE CTGAG G/A TGTAG CMDL150199 FLD0215 FLD0239 nonsynonymous EGFR c.2300C>T p.A767V gCc/gTc chr7 55249002 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249002", "IGV") low 0.500 4 no call LowQual 10 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs397517107, COSM26445 deleterious(0) probably_damaging(1) uncertain_significance 82 FFPE GATGG C/T CAGCG CMDL150199 FLD0215 FLD0239 nonsynonymous EGFR c.2311A>G p.N771D Aac/Gac chr7 55249013 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55249013", "IGV") low 0.500 4 no call pass 50 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs727503020, COSM53189 tolerated(0.16) benign(0.03) drug_response 80 FFPE TGGAC A/G ACCCC CMDL150199 FLD0215 FLD0239 nonsynonymous EGFR c.2314C>T p.P772S Ccc/Tcc chr7 55249016 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249016", "IGV") low 1.000 12 pass no call 269 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs746677478 deleterious(0) probably_damaging(0.95) 77 FFPE ACAAC C/T CCCAC CMDL150199 FLD0215 FLD0239 nonsynonymous EGFR c.2317C>T p.H773Y Cac/Tac chr7 55249019 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249019", "IGV") low 0.500 4 no call pass 50 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs767075090 tolerated(0.54) benign(0.102) 74 FFPE ACCCC C/T ACGTG CMDL150199 FLD0215 FLD0239 stop_gained EGFR c.2359C>T p.Q787* Cag/Tag chr7 55249061 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249061", "IGV") low 1.000 6 pass no call 226 EGFR_E00001601336_1 ENSG00000146648 20 of 28 32 FFPE CCGTG C/T AGCTC CMDL150199 FLD0215 FLD0239 nonsynonymous EGFR c.2398G>A p.D800N Gac/Aac chr7 55249100 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249100", "IGV") low 0.182 3970 no call QD 4189 EGFR_E00001601336_2 ENSG00000146648 20 of 28 COSM53289 deleterious(0.03) possibly_damaging(0.822) 79 FFPE TCCTG G/A ACTAT CMDL150199 FLD0215 FLD0239 synonymous EGFR c.2412A>G c.2412A>G(p.%3D) gaA/gaG chr7 55249114 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55249114", "IGV") low 0.139 3970 no call QD 398 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs746272455, COSM1451603 81 FFPE CGGGA A/G CACAA CMDL150199 FLD0215 FLD0239 intron EGFR c.2626-22C>T chr7 55260437 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260437", "IGV") medium 0.264 5125 no call pass 18817 EGFR_E00001631695_1 ENSG00000146648 21 of 27 rs190385690 T:0.0002 50 FFPE CACTG C/T CTCAT CMDL150199 FLD0215 FLD0239 intron EGFR c.2626-19C>T chr7 55260440 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260440", "IGV") medium 0.264 5125 no call pass 19027 EGFR_E00001631695_1 ENSG00000146648 21 of 27 rs17337360 T:0.0278 53 FFPE TGCCT C/T ATCTC CMDL150199 FLD0215 FLD0239 stop_gained EGFR c.2639G>A p.W880* tGg/tAg chr7 55260472 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260472", "IGV") low 0.188 5125 no call QD 6269 EGFR_E00001631695_1 ENSG00000146648 22 of 28 81 FFPE CAAGT G/A GATGG CMDL150199 FLD0215 FLD0239 nonsynonymous EGFR c.2645C>T p.A882V gCa/gTa chr7 55260478 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260478", "IGV") medium 0.359 1750 pass no call 9699 EGFR_E00001631695_1 ENSG00000146648 22 of 28 deleterious(0) probably_damaging(0.999) 75 FFPE GATGG C/T ATTGG CMDL150199 FLD0215 FLD0239 nonsynonymous,splice_region EGFR c.2470G>A p.G824S Ggc/Agc chr7 55259412 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259412", "IGV") medium 0.591 3976 no call pass 47608 EGFR_E00001681524_1 ENSG00000146648 21 of 28 deleterious(0.02) probably_damaging(0.997) 41 FFPE TTCAG G/A GCATG CMDL150199 FLD0215 FLD0239 nonsynonymous EGFR c.2503C>T p.H835Y Cac/Tac chr7 55259445 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259445", "IGV") medium 0.237 5160 pass no call 11528 EGFR_E00001681524_1 ENSG00000146648 21 of 28 deleterious(0) probably_damaging(0.995) 74 FFPE TGGTG C/T ACCGC CMDL150199 FLD0215 FLD0239 nonsynonymous EGFR c.2575G>A p.A859T Gcc/Acc chr7 55259517 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259517", "IGV") medium 0.153 2519 pass no call 5243 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM12675 deleterious(0) probably_damaging(0.999) 9 FFPE GGCTG G/A CCAAA CMDL150199 FLD0215 FLD0239 synonymous EGFR c.3129C>T c.3129C>T(p.%3D) aaC/aaT chr7 55269442 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269442", "IGV") medium 0.307 4631 pass no call 18962 EGFR_E00001773562_1 ENSG00000146648 26 of 28 53 FFPE AGCAA C/T AATTC CMDL150199 FLD0215 FLD0239 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") medium 0.575 1916 no call pass 41509 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150199 FLD0215 FLD0239 nonsynonymous EGFR c.2716G>A p.E906K Gag/Aag chr7 55266424 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266424", "IGV") medium 0.255 3840 no call pass 11951 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(1) 41 FFPE TTTGG G/A AGTTG CMDL150199 FLD0215 FLD0239 synonymous EGFR c.2760C>T c.2760C>T(p.%3D) gcC/gcT chr7 55266468 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266468", "IGV") low 0.171 3840 no call QD 3310 EGFR_E00001779947_1 ENSG00000146648 23 of 28 84 FFPE CCTGC C/T AGCGA CMDL150199 FLD0215 FLD0239 nonsynonymous EGFR c.2794C>T p.R932C Cgc/Tgc chr7 55266502 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266502", "IGV") low 0.206 5110 no call QD 9576 EGFR_E00001779947_2 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(1) 26 FFPE GAGAA C/T GCCTC CMDL150199 FLD0215 FLD0239 stop_gained EGFR c.2803C>T p.Q935* Cag/Tag chr7 55266511 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266511", "IGV") medium 0.311 5110 no call pass 23244 EGFR_E00001779947_2 ENSG00000146648 23 of 28 35 FFPE TCCCT C/T AGCCA CMDL150199 FLD0215 FLD0239 intron EGFR c.2849-27C>T chr7 55267982 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55267982", "IGV") medium 0.459 1730 pass no call 27730 EGFR_E00001790701_1 ENSG00000146648 23 of 27 rs745315446 24 FFPE AATTG C/T ACTGT CMDL150199 FLD0215 FLD0239 synonymous EGFR c.2991C>T c.2991C>T(p.%3D) ttC/ttT chr7 55268925 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268925", "IGV") low 0.177 4195 QD no call 3939 EGFR_E00001801208_1 ENSG00000146648 25 of 28 COSM3639756 43 FFPE AACTT C/T TACCG CMDL150199 FLD0215 FLD0239 synonymous EGFR c.3045G>A c.3045G>A(p.%3D) gaG/gaA chr7 55268979 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268979", "IGV") medium 0.730 4348 no call pass 74704 EGFR_E00001801208_2 ENSG00000146648 25 of 28 41 FFPE GACGA G/A TACCT CMDL150199 FLD0215 FLD0239 nonsynonymous EGFR c.2206G>A p.E736K Gag/Aag chr7 55242436 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55242436", "IGV") medium 0.277 3979 no call pass 14261 EGFR_Exon19 ENSG00000146648 19 of 28 deleterious(0) probably_damaging(0.999) 42 FFPE AAGGT G/A AGAAA CMDL150199 FLD0215 FLD0239 nonsynonymous EGFR c.2221C>T p.P741S Ccc/Tcc chr7 55242451 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55242451", "IGV") medium 0.498 2125 pass no call 20449 EGFR_Exon19 ENSG00000146648 19 of 28 tolerated(0.07) probably_damaging(0.991) 57 FFPE AAATT C/T CCGTC CMDL150199 FLD0215 FLD0239 intron TP53 c.97-51C>T chr17 7579641 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579641", "IGV") medium 0.370 105 pass no call 469 EXP0116_TP53_E3 ENSG00000141510 3 of 10 65 FFPE CCCCA G/A CCCCC CMDL150199 FLD0215 FLD0239 intron TP53 c.75-9G>A chr17 7579730 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579730", "IGV") low 0.247 66 pass no call 422 EXP0116_TP53_E3 ENSG00000141510 2 of 10 5 FFPE AAAGA C/T AAGAG CMDL150199 FLD0215 FLD0239 nonsynonymous TP53 c.173C>T p.P58L cCa/cTa chr17 7579514 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579514", "IGV") low 0.191 4398 QD no call 7360 EXP0116_TP53_E4 ENSG00000141510 4 of 11 rs144386518, TP53_g.11404C>T, TP53_g.11404C>A, COSM87857, COSM43677, COSM44050, COSM1740363, COSM1740365, COSM1740364 tolerated(0.34) benign(0.04) uncertain_significance,not_provided 18 FFPE GACCT G/A GGTCT CMDL150199 FLD0215 FLD0239 nonsynonymous KRAS c.35G>A p.G12D gGt/gAt chr12 25398284 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") medium 0.499 884 pass no call 9981 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) benign(0.361) 26 FFPE CGCCA C/T CAGCT CMDL150199 FLD0215 FLD0239 synonymous PIK3CA c.1554T>C c.1554T>C(p.%3D) gcT/gcC chr3 178936012 T C =hyperlink("http://localhost:60151/goto?locus=chr3:178936012", "IGV") medium 0.674 1146 no call pass 17266 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 48 FFPE CTAGC T/C AGAGA CMDL150199 FLD0215 FLD0239 nonsynonymous PIK3CA c.1598C>T p.A533V gCa/gTa chr3 178936056 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178936056", "IGV") low 0.270 71 pass no call 232 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 COSM29314 tolerated(0.12) benign(0.049) 71 FFPE CAAAG C/T AATTT CMDL150199 FLD0215 FLD0239 intron PTEN c.802-12T>C chr10 89720639 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720639", "IGV") low 0.012 63 QD no call 47 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs587781129 benign 46 FFPE TTTTT T/C TTTTT CMDL150199 FLD0215 FLD0239 nonsynonymous PTEN c.871G>A p.E291K Gaa/Aaa chr10 89720720 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720720", "IGV") medium 0.284 4220 no call pass 15476 PTEN_E00001156315_5 ENSG00000171862 8 of 9 COSM28906, COSM13451 tolerated(0.16) benign(0.099) 45 FFPE AAGTA G/A AAAAT CMDL150199 FLD0215 FLD0239 nonsynonymous PTEN c.887G>A p.C296Y tGt/tAt chr10 89720736 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720736", "IGV") low 0.138 4220 no call QD 312 PTEN_E00001156315_5 ENSG00000171862 8 of 9 tolerated(1) benign(0.116) 36 FFPE TCTAT G/A TGATC CMDL150199 FLD0215 FLD0239 synonymous PTEN c.993C>T c.993C>T(p.%3D) gaC/gaT chr10 89720842 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720842", "IGV") low 0.194 5214 no call QD 6292 PTEN_E00001156315_7 ENSG00000171862 8 of 9 COSM5814 54 FFPE AAAGA C/T AAAGC CMDL150199 FLD0215 FLD0239 nonsynonymous PTEN c.638C>T p.P213L cCt/cTt chr10 89717613 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717613", "IGV") medium 0.488 3436 pass no call 31076 PTEN_E00001156321_1 ENSG00000171862 7 of 9 COSM17561, COSM241294, COSM23646 tolerated(0.49) benign(0.088) 43 FFPE AGATC C/T TCAGT CMDL150199 FLD0215 FLD0239 synonymous PTEN c.738G>A c.738G>A(p.%3D) ccG/ccA chr10 89717713 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717713", "IGV") medium 0.429 4251 no call pass 31469 PTEN_E00001156321_2 ENSG00000171862 7 of 9 rs774364894, COSM5822, COSM921126 63 FFPE CAGCC G/A TTACC CMDL150199 FLD0215 FLD0239 synonymous PTEN c.309C>T c.309C>T(p.%3D) ccC/ccT chr10 89692825 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692825", "IGV") medium 0.398 3594 no call pass 24548 PTEN_E00001156330_1 ENSG00000171862 5 of 9 COSM1349502 58 FFPE AAACC C/T TTTTG CMDL150199 FLD0215 FLD0239 nonsynonymous PTEN c.362C>T p.A121V gCa/gTa chr10 89692878 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692878", "IGV") medium 0.358 3594 no call pass 19554 PTEN_E00001156330_1 ENSG00000171862 5 of 9 rs121909237, COSM5273 tolerated(0.42) possibly_damaging(0.669) pathogenic 21 FFPE TGCAG C/T AATTC CMDL150199 FLD0215 FLD0239 nonsynonymous PTEN c.442G>A p.A148T Gca/Aca chr10 89692958 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692958", "IGV") medium 0.887 997 pass no call 21189 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5071, COSM1561206 tolerated(0.06) benign(0.394) 67 FFPE TAAAG G/A CACAA CMDL150199 FLD0215 FLD0239 nonsynonymous,splice_region PTEN c.82A>G p.I28V Att/Gtt chr10 89653784 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89653784", "IGV") low 0.243 74 no call pass 195 PTEN_E00001156351_1 ENSG00000171862 2 of 9 deleterious(0.02) benign(0.204) 17 FFPE CAGAT A/G TTTAT CMDL150199 FLD0215 FLD0239 nonsynonymous PTEN c.1051G>A p.V351I Gta/Ata chr10 89725068 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725068", "IGV") medium 0.155 3430 pass no call 11506 PTEN_E00001456541_1 ENSG00000171862 9 of 9 tolerated(0.17) benign(0.374) 46 FFPE AAACA G/A TAGAG CMDL150199 FLD0215 FLD0239 synonymous PTEN c.1074G>A c.1074G>A(p.%3D) gaG/gaA chr10 89725091 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725091", "IGV") low 0.153 3430 QD no call 3342 PTEN_E00001456541_1 ENSG00000171862 9 of 9 69 FFPE CCAGA G/A GCTAG CMDL150199 FLD0215 FLD0239 nonsynonymous PTEN c.1126C>T p.H376Y Cat/Tat chr10 89725143 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725143", "IGV") medium 0.287 4281 no call pass 16738 PTEN_E00001456541_1 ENSG00000171862 9 of 9 deleterious_low_confidence(0.01) possibly_damaging(0.521) 18 FFPE CTGAT C/T ATTAT CMDL150199 FLD0215 FLD0239 nonsynonymous PTEN c.1168G>A p.E390K Gaa/Aaa chr10 89725185 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725185", "IGV") low 0.160 5921 QD no call 2113 PTEN_E00001456541_2 ENSG00000171862 9 of 9 tolerated_low_confidence(0.1) benign(0.006) 56 FFPE AGAAT G/A AACCT CMDL150199 FLD0215 FLD0239 intron TP53 c.993+159C>T chr17 7576694 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576694", "IGV") low 0.142 4786 no call QD 1499 TP53_00001404886_13 ENSG00000141510 9 of 10 21 FFPE GTTCT G/A AAGTT CMDL150199 FLD0215 FLD0239 splice_donor TP53 c.672+1G>A chr17 7578176 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578176", "IGV") medium 0.235 2302 no call pass 5660 TP53_E00001255919_1 ENSG00000141510 6 of 10 CS071266, TP53_g.12742G>T, TP53_g.12742G>A, TP53_g.12742del, TP53_g.12742G>C, COSM6906, COSM13586, COSM45367, COSM118941, COSM121038, COSM119013, COSM121039, COSM118939, COSM119011, COSM3388194, COSM3723947, COSM1638407, COSM2744696, COSM118940, COSM119012, COSM121040 67 FFPE CCAGA C/T CTCAG CMDL150199 FLD0215 FLD0239 synonymous TP53 c.630C>T c.630C>T(p.%3D) aaC/aaT chr17 7578219 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578219", "IGV") low 0.159 2302 no call QD 1506 TP53_E00001255919_1 ENSG00000141510 6 of 11 TP53_g.12699C>G, TP53_g.12699C>T, TP53_g.12699del, COSM44722, COSM45863, COSM46169 34 FFPE AAAGT G/A TTTCT CMDL150199 FLD0215 FLD0239 synonymous TP53 c.567C>T c.567C>T(p.%3D) gcC/gcT chr17 7578282 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578282", "IGV") low 0.107 2033 no call QD 3308 TP53_E00001255919_3 ENSG00000141510 6 of 11 rs55764374, TP53_g.12636C>T, COSM45440, COSM1564179, COSM1564180, COSM1564181, COSM1564183, COSM1564182 33 FFPE GGAGG G/A GCCAG CMDL150199 FLD0215 FLD0239 intron TP53 c.560-18C>T chr17 7578307 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578307", "IGV") low 0.104 2033 no call QD 3308 TP53_E00001255919_3 ENSG00000141510 5 of 10 58 FFPE AGTGA G/A GAATC CMDL150199 FLD0215 FLD0239 intron TP53 c.559+34G>A chr17 7578337 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578337", "IGV") medium 0.535 2033 no call pass 22583 TP53_E00001255919_3 ENSG00000141510 5 of 10 53 FFPE GCAAC C/T AGCCC CMDL150199 FLD0215 FLD0239 splice_region,intron TP53 c.559+3G>A chr17 7578368 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578368", "IGV") medium 0.532 2033 no call pass 21918 TP53_E00001255919_3 ENSG00000141510 5 of 10 rs150098764, TP53_g.12550G>A, TP53_g.12550G>C, COSM43541, COSM44410 A:0.0002 22 FFPE CTGCT C/T ACCAT CMDL150199 FLD0215 FLD0239 nonsynonymous TP53 c.509C>T p.T170M aCg/aTg chr17 7578421 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578421", "IGV") medium 0.281 3373 pass no call 11936 TP53_E00001255919_5 ENSG00000141510 5 of 11 rs779000871, TP53_g.12497C>A, TP53_g.12497C>T, TP53_g.12497del, COSM44552 tolerated(0.13) probably_damaging(0.993) uncertain_significance 43 FFPE CCTCC G/A TCATG CMDL150199 FLD0215 FLD0239 synonymous TP53 c.486C>T c.486C>T(p.%3D) atC/atT chr17 7578444 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578444", "IGV") low 0.142 3373 QD no call 566 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12474C>A, TP53_g.12474C>G, TP53_g.12474C>T, COSM44125, COSM45627, COSM44694 65 FFPE TTGTA G/A ATGGC CMDL150199 FLD0215 FLD0239 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") medium 0.503 976 no call pass 9912 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150199 FLD0215 FLD0239 intron TP53 c.375+23C>T chr17 7579289 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579289", "IGV") low 0.172 3891 QD no call 1841 TP53_E00001612188_1 ENSG00000141510 4 of 10 10 FFPE TGGAA G/A CCAGC CMDL150199 FLD0215 FLD0239 nonsynonymous TP53 c.364G>A p.V122M Gtg/Atg chr17 7579323 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579323", "IGV") medium 0.409 4067 no call pass 28635 TP53_E00001612188_1 ENSG00000141510 4 of 11 rs587781495, TP53_g.11595G>T, COSM45917, COSM1386832, COSM1386833, COSM1386834 deleterious(0) probably_damaging(0.996) uncertain_significance 44 FFPE AGTCA C/T AGACT CMDL150199 FLD0215 FLD0239 synonymous TP53 c.339C>T c.339C>T(p.%3D) ttC/ttT chr17 7579348 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579348", "IGV") medium 0.398 3891 pass no call 26382 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11570C>G, TP53_g.11570C>T, COSM44942, COSM1386856, COSM1386857, COSM4070059, COSM4070062, COSM1386858, COSM4070061, COSM4070060 58 FFPE TGCAA G/A AAGCC CMDL150199 FLD0215 FLD0239 nonsynonymous TP53 c.292C>T p.P98S Cct/Tct chr17 7579395 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579395", "IGV") medium 0.338 4067 no call pass 24236 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11523C>T, COSM12296, COSM1386881, COSM1386882 deleterious(0) probably_damaging(1) 11 FFPE GGAAG G/A GACAG CMDL150199 FLD0215 FLD0239 synonymous TP53 c.291C>T c.291C>T(p.%3D) gtC/gtT chr17 7579396 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579396", "IGV") medium 0.340 4067 no call pass 23703 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11522C>T, COSM473435, COSM473436, COSM473437 10 FFPE GAAGG G/A ACAGA CMDL150199 FLD0215 FLD0239 nonsynonymous TP53 c.275C>T p.P92L cCc/cTc chr17 7579412 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579412", "IGV") medium 0.271 2801 pass no call 10870 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11506C>T, COSM45972 deleterious(0.03) possibly_damaging(0.625) 35 FFPE ACAGG G/A GCCAG CMDL150199 FLD0215 FLD0239 synonymous TP53 c.267C>T c.267C>T(p.%3D) ccC/ccT chr17 7579420 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579420", "IGV") low 0.136 2801 QD no call 782 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs587783062, TP53_g.11498C>T, TP53_g.11498del, COSM1268330, COSM1180853, COSM1180854 likely_pathogenic 43 FFPE CAGGA G/A GGGGC CMDL150199 FLD0215 FLD0239 nonsynonymous TP53 c.259C>T p.P87S Cca/Tca chr17 7579428 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579428", "IGV") medium 0.251 2801 pass no call 8556 TP53_E00001612188_2 ENSG00000141510 4 of 11 tolerated(0.36) possibly_damaging(0.45) 51 FFPE GGCTG G/A TGCAG CMDL150199 FLD0215 FLD0239 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.965 0.816 2801 1756 pass pass 73235 34246 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150199 FLD0215 FLD0239 intron TP53 c.782+40G>A chr17 7577459 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577459", "IGV") medium 0.730 1698 no call pass 47430 TP53_E00001665758_1 ENSG00000141510 7 of 10 10 FFPE TGGGG C/T ACAGC CMDL150199 FLD0215 FLD0239 intron TP53 c.782+23G>A chr17 7577476 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577476", "IGV") medium 0.323 1424 pass no call 15046 TP53_E00001665758_1 ENSG00000141510 7 of 10 27 FFPE GTGTG C/T AGGGT CMDL150199 FLD0215 FLD0239 splice_region,intron TP53 c.782+8G>A chr17 7577491 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577491", "IGV") medium 0.435 2863 pass no call 23276 TP53_E00001665758_1 ENSG00000141510 7 of 10 42 FFPE AGTGG C/T TCCTG CMDL150199 FLD0215 FLD0239 nonsynonymous TP53 c.682G>A p.D228N Gac/Aac chr17 7577599 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577599", "IGV") medium 0.438 1434 pass no call 18848 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13319G>T, TP53_g.13319G>C, TP53_g.13319G>A, COSM45786, COSM44398, COSM46213, COSM1640836, COSM1640838, COSM1640837, COSM1640839 tolerated(0.07) benign(0.102) 13 FFPE ACAGT C/T AGAGC CMDL150199 FLD0215 FLD0239 nonsynonymous TP53 c.1078G>A p.G360R Ggg/Agg chr17 7573949 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573949", "IGV") medium 0.489 4045 no call pass 43692 TP53_E00001728015_1 ENSG00000141510 10 of 11 tolerated(0.53) benign(0.016) 69 FFPE CCCCC C/T TGGCT CMDL150199 FLD0215 FLD0239 nonsynonymous TP53 c.1067G>A p.G356E gGg/gAg chr17 7573960 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573960", "IGV") medium 0.490 4045 no call pass 44016 TP53_E00001728015_1 ENSG00000141510 10 of 11 TP53_g.16958G>C tolerated(0.98) benign(0.012) 77 FFPE CCTTC C/T CAGCC CMDL150199 FLD0215 FLD0239 synonymous TP53 c.1053G>A c.1053G>A(p.%3D) aaG/aaA chr17 7573974 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573974", "IGV") medium 0.569 3307 pass no call 38237 TP53_E00001728015_1 ENSG00000141510 10 of 11 TP53_g.16944G>T, COSM3362446, COSM3362447 63 FFPE GCATC C/T TTGAG CMDL150199 FLD0215 FLD0239 3_prime_UTR TP53 c.*36C>T chr17 7572891 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572891", "IGV") medium 0.386 1768 no call pass 12239 TP53_E00001757276_1 ENSG00000141510 11 of 11 22 FFPE GGGGT G/A GGAGG CMDL150199 FLD0215 FLD0239 synonymous TP53 c.1113C>T c.1113C>T(p.%3D) tcC/tcT chr17 7572996 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572996", "IGV") medium 0.285 2207 pass no call 8056 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs765530090 15 FFPE TTTTT G/A GACTT CMDL150199 FLD0215 FLD0239 intron TP53 c.993+35G>A chr17 7576818 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576818", "IGV") medium 0.302 2656 no call pass 25181 TP53_E00001789298_1 ENSG00000141510 9 of 10 rs149983651 G:0.0002 12 FFPE GGAAA C/T TTTCC CMDL150199 FLD0215 FLD0239 intron TP53 c.993+19T>C chr17 7576834 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7576834", "IGV") medium 0.292 3118 pass no call 11723 TP53_E00001789298_1 ENSG00000141510 9 of 10 rs370042486 28 FFPE ATAAG A/G GGTCC CMDL150199 FLD0215 FLD0239 synonymous TP53 c.984C>T c.984C>T(p.%3D) ttC/ttT chr17 7576862 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576862", "IGV") medium 0.279 3120 pass no call 11365 TP53_E00001789298_1 ENSG00000141510 9 of 11 TP53_g.14056C>T, COSM44833 56 FFPE AGGGT G/A AAATA CMDL150199 FLD0215 FLD0239 intron TP53 c.919+30G>A chr17 7576989 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576989", "IGV") low 0.143 4999 no call QD 584 TP53_E00001789298_2 ENSG00000141510 8 of 10 64 FFPE GGTCT C/T CTCCA CMDL150199 FLD0215 FLD0239 synonymous TP53 c.861G>A c.861G>A(p.%3D) gaG/gaA chr17 7577077 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577077", "IGV") low 0.191 4220 QD no call 6268 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs748891343, TP53_g.13841G>T, TP53_g.13841G>A, TP53_g.13841G>C, COSM43776, COSM44077, COSM46366 55 FFPE AGATT C/T TCTTC CMDL150199 FLD0215 FLD0239 nonsynonymous TP53 c.835G>A p.G279R Ggg/Agg chr17 7577103 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577103", "IGV") medium 0.189 4220 pass no call 20866 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13815G>T, TP53_g.13815G>A, TP53_g.13815G>C, TP53_g.13815del, COSM44603, COSM46298, COSM43674, COSM44005, COSM417973, COSM99755, COSM1386597 deleterious(0) probably_damaging(0.999) 64 FFPE TCTCC C/T AGGAC CMDL150199 FLD0215 FLD0239 nonsynonymous TP53 c.811G>A p.E271K Gag/Aag chr17 7577127 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577127", "IGV") medium 0.190 4220 pass no call 21063 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13791del, TP53_g.13791G>T, TP53_g.13791G>A, TP53_g.13791G>C, COSM43750, COSM10719, COSM43706, COSM131516, COSM254988, COSM165082, COSM3403256, COSM1646807, COSM1646806 deleterious(0) probably_damaging(0.999) 40 FFPE CACCT C/T AAAGC NTC_018 FLD0216 FLD0240 nonsynonymous BRAF c.1771A>G p.K591E Aaa/Gaa chr7 140453164 T C =hyperlink("http://localhost:60151/goto?locus=chr7:140453164", "IGV") low 0.500 2 no call LowQual 22 BRAF_AA_HS ENSG00000157764 15 of 18 COSM1448598 deleterious(0) possibly_damaging(0.818) 38 Blank TATTT T/C TACTG NTC_018 FLD0216 FLD0240 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") low 0.509 55 pass no call 997 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 Blank GTGCA G/A CTCAT NTC_018 FLD0216 FLD0240 nonsynonymous EGFR c.2396T>G p.L799R cTg/cGg chr7 55249098 T G =hyperlink("http://localhost:60151/goto?locus=chr7:55249098", "IGV") low 0.500 4 no call pass 50 EGFR_E00001601336_2 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(1) 77 Blank CCTCC T/G GGACT NTC_018 FLD0216 FLD0240 nonsynonymous EGFR c.2398G>A p.D800N Gac/Aac chr7 55249100 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249100", "IGV") low 0.500 4 no call pass 50 EGFR_E00001601336_2 ENSG00000146648 20 of 28 COSM53289 deleterious(0.03) possibly_damaging(0.822) 79 Blank TCCTG G/A ACTAT NTC_018 FLD0216 FLD0240 nonsynonymous EGFR c.2404G>A p.V802I Gtc/Atc chr7 55249106 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249106", "IGV") medium 0.527 107 pass no call 2215 EGFR_E00001601336_2 ENSG00000146648 20 of 28 COSM28516, COSM1651734 tolerated(0.06) benign(0.017) 85 Blank ACTAT G/A TCCGG NTC_018 FLD0216 FLD0240 synonymous EGFR c.2406C>T c.2406C>T(p.%3D) gtC/gtT chr7 55249108 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249108", "IGV") medium 0.402 107 pass no call 767 EGFR_E00001601336_2 ENSG00000146648 20 of 28 87 Blank TATGT C/T CGGGA NTC_018 FLD0216 FLD0240 nonsynonymous EGFR c.2410G>A p.E804K Gaa/Aaa chr7 55249112 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249112", "IGV") medium 0.536 107 pass no call 2215 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs552733360, COSM249780 tolerated(0.07) possibly_damaging(0.906) A:0.0002 83 Blank TCCGG G/A AACAC NTC_018 FLD0216 FLD0240 intron EGFR c.2626-44G>A chr7 55260415 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260415", "IGV") low 0.984 63 pass no call 2562 EGFR_E00001631695_1 ENSG00000146648 21 of 27 28 Blank AGAGG G/A AAACT NTC_018 FLD0216 FLD0240 splice_region,intron EGFR c.2470-6T>C chr7 55259406 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55259406", "IGV") low 0.500 4 no call pass 50 EGFR_E00001681524_1 ENSG00000146648 20 of 27 35 Blank CTCTG T/C TTCAG NTC_018 FLD0216 FLD0240 splice_acceptor EGFR c.2470-2A>G chr7 55259410 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55259410", "IGV") low 0.500 4 no call pass 50 EGFR_E00001681524_1 ENSG00000146648 20 of 27 39 Blank GTTTC A/G GGGCA NTC_018 FLD0216 FLD0240 synonymous EGFR c.2496C>T c.2496C>T(p.%3D) cgC/cgT chr7 55259438 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259438", "IGV") medium 0.519 156 pass no call 1519 EGFR_E00001681524_1 ENSG00000146648 21 of 28 67 Blank CGTCG C/T TTGGT NTC_018 FLD0216 FLD0240 nonsynonymous EGFR c.2575G>A p.A859T Gcc/Acc chr7 55259517 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259517", "IGV") medium 0.426 133 pass no call 943 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM12675 deleterious(0) probably_damaging(0.999) 55 Blank GGCTG G/A CCAAA NTC_018 FLD0216 FLD0240 synonymous EGFR c.2583G>A c.2583G>A(p.%3D) ctG/ctA chr7 55259525 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259525", "IGV") medium 0.353 133 pass no call 841 EGFR_E00001681524_2 ENSG00000146648 21 of 28 47 Blank AAACT G/A CTGGG NTC_018 FLD0216 FLD0240 nonsynonymous EGFR c.2590G>A p.A864T Gcg/Acg chr7 55259532 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259532", "IGV") medium 0.423 133 pass no call 933 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM13197 tolerated(0.27) probably_damaging(0.911) 40 Blank TGGGT G/A CGGAA NTC_018 FLD0216 FLD0240 intron EGFR c.3115-60G>A chr7 55269368 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269368", "IGV") low 0.333 6 no call pass 44 EGFR_E00001773562_1 ENSG00000146648 25 of 27 14 Blank TTCAG G/A AAAAG NTC_018 FLD0216 FLD0240 intron EGFR c.3115-41G>A chr7 55269387 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269387", "IGV") low 0.333 6 no call pass 44 EGFR_E00001773562_1 ENSG00000146648 25 of 27 33 Blank ATGTG G/A TACAA NTC_018 FLD0216 FLD0240 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") low 1.000 3 pass no call 100 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 Blank GTGAC T/C GTTTG NTC_018 FLD0216 FLD0240 synonymous EGFR c.2779C>T c.2779C>T(p.%3D) Ctg/Ttg chr7 55266487 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266487", "IGV") low 1.000 6 pass no call 120 EGFR_E00001779947_1 ENSG00000146648 23 of 28 rs374672672 65 Blank CCATC C/T TGGAG NTC_018 FLD0216 FLD0240 intron EGFR c.3114+23T>C chr7 55269071 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55269071", "IGV") low 0.172 55 QD no call 54 EGFR_E00001801208_2 ENSG00000146648 25 of 27 8 Blank CTCTC T/C CTCTC NTC_018 FLD0216 FLD0240 synonymous EGFR c.2271G>A c.2271G>A(p.%3D) aaG/aaA chr7 55242501 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55242501", "IGV") low 1.000 2 no call LowQual 22 EGFR_Exon19 ENSG00000146648 19 of 28 17 Blank AACAA G/A GAAAT NTC_018 FLD0216 FLD0240 nonsynonymous KRAS c.35G>A p.G12D gGt/gAt chr12 25398284 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") medium 0.966 176 pass no call 4078 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) benign(0.361) 26 Blank CGCCA C/T CAGCT NTC_018 FLD0216 FLD0240 synonymous PIK3CA c.1629C>T c.1629C>T(p.%3D) atC/atT chr3 178936087 C T =hyperlink("http://localhost:60151/goto?locus=chr3:178936087", "IGV") low 1.000 2 LowQual no call 22 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 rs772724438 40 Blank GAAAT C/T ACTGA NTC_018 FLD0216 FLD0240 3_prime_UTR PIK3CA c.*41A>G chr3 178952193 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178952193", "IGV") low 0.306 85 pass no call 776 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 15 Blank TCCAC A/G CTGCA NTC_018 FLD0216 FLD0240 nonsynonymous PTEN c.853G>A p.E285K Gaa/Aaa chr10 89720702 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720702", "IGV") medium 0.226 106 pass no call 329 PTEN_E00001156315_5 ENSG00000171862 8 of 9 tolerated(0.31) benign(0.014) 27 Blank CAGAG G/A AAACC NTC_018 FLD0216 FLD0240 splice_region,intron PTEN c.635-8C>T chr10 89717602 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717602", "IGV") low 0.200 224 QD no call 439 PTEN_E00001156321_1 ENSG00000171862 6 of 8 rs780495238 32 Blank TTTAA C/T CATGC NTC_018 FLD0216 FLD0240 nonsynonymous PTEN c.701G>A p.R234Q cGg/cAg chr10 89717676 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717676", "IGV") medium 0.248 224 pass no call 678 PTEN_E00001156321_1 ENSG00000171862 7 of 9 CM023439, rs121909235, COSM540238, COSM23654 tolerated(0.16) benign(0.022) pathogenic,risk_factor 31 Blank ACGAC G/A GGAAG NTC_018 FLD0216 FLD0240 synonymous PTEN c.618C>T c.618C>T(p.%3D) ttC/ttT chr10 89712000 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89712000", "IGV") medium 0.393 112 pass no call 791 PTEN_E00001156327_4 ENSG00000171862 6 of 9 50 Blank ATGTT C/T AGTGG NTC_018 FLD0216 FLD0240 synonymous PTEN c.198G>A c.198G>A(p.%3D) aaG/aaA chr10 89685303 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89685303", "IGV") medium 0.275 101 pass no call 459 PTEN_E00001156344_1 ENSG00000171862 3 of 9 COSM4016453, COSM5191 36 Blank TACAA G/A ATATA NTC_018 FLD0216 FLD0240 nonsynonymous PTEN c.1105G>A p.V369I Gtt/Att chr10 89725122 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725122", "IGV") medium 0.304 137 pass no call 682 PTEN_E00001456541_1 ENSG00000171862 9 of 9 rs587782224 tolerated(0.4) benign(0.007) uncertain_significance 39 Blank CAGAT G/A TTAGT NTC_018 FLD0216 FLD0240 nonsynonymous PTEN c.44G>A p.R15K aGa/aAa chr10 89624270 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624270", "IGV") low 0.197 200 QD no call 388 PTEN_E00001456562_1 ENSG00000171862 1 of 9 rs398123324, COSM5232, COSM5064 deleterious(0) benign(0.102) uncertain_significance 76 Blank AAGGA G/A ATATC NTC_018 FLD0216 FLD0240 intron TP53 c.993+206G>A chr17 7576647 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576647", "IGV") low 1.000 2 LowQual no call 22 TP53_00001404886_13 ENSG00000141510 9 of 10 40 Blank GAAAG C/T TGGTC NTC_018 FLD0216 FLD0240 intron TP53 c.993+164C>T chr17 7576689 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576689", "IGV") low 1.000 2 LowQual no call 22 TP53_00001404886_13 ENSG00000141510 9 of 10 26 Blank TTGGT G/A TTCTG NTC_018 FLD0216 FLD0240 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 1.000 2 pass no call 55 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 Blank TCACC T/C GGAGG NTC_018 FLD0216 FLD0240 nonsynonymous TP53 c.613T>A p.Y205N Tat/Aat chr17 7578236 A T =hyperlink("http://localhost:60151/goto?locus=chr17:7578236", "IGV") low 1.000 2 no call LowQual 22 TP53_E00001255919_1 ENSG00000141510 6 of 11 CD100447, TP53_g.12682T>G, TP53_g.12682T>A, TP53_g.12682del, TP53_g.12682T>C, COSM43642, COSM43844, COSM45685, COSM45525, COSM1159830, COSM1564188, COSM220762, COSM220761, COSM1564189, COSM1159831, COSM220763, COSM1564191, COSM1159833, COSM1564190, COSM220764, COSM1159832 deleterious(0) probably_damaging(0.948) 17 Blank CAAAT A/T CTCCA NTC_018 FLD0216 FLD0240 intron TP53 c.559+26A>G chr17 7578345 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578345", "IGV") low 1.000 2 no call LowQual 22 TP53_E00001255919_3 ENSG00000141510 5 of 10 45 Blank CCCTG T/C CGTCT NTC_018 FLD0216 FLD0240 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") low 1.000 1.000 4 4 pass pass 111 152 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 Blank CCACG G/C GGGGA NTC_018 FLD0216 FLD0240 stop_gained TP53 c.202G>T p.E68* Gag/Tag chr17 7579485 C A =hyperlink("http://localhost:60151/goto?locus=chr17:7579485", "IGV") low 0.500 4 no call pass 50 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11433del, TP53_g.11433G>T, TP53_g.11433G>C, COSM11513, COSM45213, COSM44917, COSM131521, COSM131522, COSM3378370, COSM1646879 16 Blank AGCCT C/A TGGCA NTC_018 FLD0216 FLD0240 nonsynonymous TP53 c.770T>C p.L257P cTg/cCg chr17 7577511 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7577511", "IGV") low 1.000 2 LowQual no call 22 TP53_E00001665758_1 25105660 ENSG00000141510 7 of 11 CD941800, rs28934577, CM941332, TP53_g.13407del, TP53_g.13407T>C, TP53_g.13407T>G, TP53_g.13407T>A, COSM44890, COSM43842, COSM43530, COSM1230108, COSM1386605, COSM1230109, COSM1386606, COSM4139865, COSM3378344, COSM4139864, COSM3378343 deleterious(0) probably_damaging(1) likely_pathogenic,pathogenic 62 Blank CTTCC A/G GTGTG NTC_018 FLD0216 FLD0240 nonsynonymous TP53 c.718A>G p.S240G Agt/Ggt chr17 7577563 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7577563", "IGV") low 1.000 2 LowQual no call 22 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13355A>G, TP53_g.13355del, TP53_g.13355A>T, TP53_g.13355A>C, COSM43973, COSM44217, COSM44621, COSM45804, COSM984909, COSM984911, COSM984912 deleterious(0) probably_damaging(1) 49 Blank GGAAC T/C GTTAC CMDL140043 FLD0337 FLD0361 intron EGFR c.2284-21C>T chr7 55248965 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248965", "IGV") medium 0.299 3317 pass no call 14788 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs201251727 T:0.0012 45 FFPE ACTGA C/T GTGCC CMDL140043 FLD0337 FLD0361 intron EGFR c.2284-11C>T chr7 55248975 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248975", "IGV") medium 0.314 3317 pass no call 16772 EGFR_E00001601336_1 ENSG00000146648 19 of 27 55 FFPE CTCTC C/T CTCCC CMDL140043 FLD0337 FLD0361 synonymous EGFR c.2316C>T c.2316C>T(p.%3D) ccC/ccT chr7 55249018 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249018", "IGV") medium 0.308 3317 pass no call 33338 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs761020556, COSM13434, COSM12388 75 FFPE AACCC C/T CACGT CMDL140043 FLD0337 FLD0361 synonymous EGFR c.2319C>T c.2319C>T(p.%3D) caC/caT chr7 55249021 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249021", "IGV") medium 0.306 3317 pass no call 32376 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs768468531 72 FFPE CCCCA C/T GTGTG CMDL140043 FLD0337 FLD0361 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.984 0.987 1612 2028 pass pass 69152 84556 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140043 FLD0337 FLD0361 synonymous EGFR c.2376C>T c.2376C>T(p.%3D) ctC/ctT chr7 55249078 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249078", "IGV") medium 0.142 1612 pass no call 4088 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM3833028 15 FFPE CAGCT C/T ATGCC CMDL140043 FLD0337 FLD0361 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.990 0.994 1774 1886 pass pass 88047 97107 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140043 FLD0337 FLD0361 splice_region,intron EGFR c.2470-3C>T chr7 55259409 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259409", "IGV") low 0.133 4581 no call QD 246 EGFR_E00001681524_1 ENSG00000146648 20 of 27 38 FFPE TGTTT C/T AGGGC CMDL140043 FLD0337 FLD0361 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.998 0.960 1778 2078 pass pass 76792 82904 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140043 FLD0337 FLD0361 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.562 0.548 3794 4404 pass pass 47772 53322 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL140043 FLD0337 FLD0361 intron TP53 c.97-39G>A chr17 7579629 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579629", "IGV") medium 0.625 965 no call pass 16178 EXP0116_TP53_E3 ENSG00000141510 3 of 10 53 FFPE AGGTC C/T TCAGC CMDL140043 FLD0337 FLD0361 intron TP53 c.97-44G>A chr17 7579634 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579634", "IGV") medium 0.650 965 no call pass 16863 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs762445877 58 FFPE CTCAG C/T CCCCC CMDL140043 FLD0337 FLD0361 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") medium 0.197 379 pass no call 1245 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL140043 FLD0337 FLD0361 nonsynonymous PIK3CA c.1616C>G p.P539R cCt/cGt chr3 178936074 C G =hyperlink("http://localhost:60151/goto?locus=chr3:178936074", "IGV") high 0.467 0.553 1717 1768 pass pass 16782 21737 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 rs121913285, COSM759, COSM446010 deleterious(0) possibly_damaging(0.796) 53 FFPE AGATC C/G TCTCT CMDL140043 FLD0337 FLD0361 intron PTEN c.802-12T>C chr10 89720639 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720639", "IGV") low 0.014 110 LowQual,QD no call 21 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs587781129 benign 46 FFPE TTTTT T/C TTTTT CMDL140043 FLD0337 FLD0361 synonymous TP53 c.639A>G c.639A>G(p.%3D) cgA/cgG chr17 7578210 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578210", "IGV") high 0.498 0.487 2757 3238 pass pass 27778 34020 TP53_E00001255919_1 20455025, 18798306, 15450681, 23543587, 24218030, 22829934, 18594532, 21869887, 17133269 ENSG00000141510 6 of 11 CX984230, rs1800372, TP53_g.12708A>T, COSM249885, COSM1741221, COSM1741223, COSM1741225, COSM3755916, COSM1741222, COSM1741224 benign C:0.0054 43 FFPE CTATG T/C CGAAA CMDL140043 FLD0337 FLD0361 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") medium 0.169 1264 no call pass 4823 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL140043 FLD0337 FLD0361 intron TP53 c.74+53C>T chr17 7579786 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579786", "IGV") medium 0.205 1115 pass no call 5799 TP53_E00001596491_1 ENSG00000141510 2 of 10 9 FFPE TAGGG G/A GCTGG CMDL140043 FLD0337 FLD0361 intron TP53 c.74+47C>T chr17 7579792 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579792", "IGV") low 0.205 2536 no call QD 4925 TP53_E00001596491_1 ENSG00000141510 2 of 10 15 FFPE GCTGG G/A GTTGG CMDL140043 FLD0337 FLD0361 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.997 0.988 2179 2536 pass pass 85007 96053 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140043 FLD0337 FLD0361 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") low 0.189 2179 QD no call 3799 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL140043 FLD0337 FLD0361 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.993 0.990 825 1120 pass pass 29646 37490 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140043 FLD0337 FLD0361 3_prime_UTR TP53 c.*41C>T chr17 7572886 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572886", "IGV") medium 0.257 3984 no call pass 20560 TP53_E00001757276_1 ENSG00000141510 11 of 11 17 FFPE AGATG G/A GGGTG CMDL140043 FLD0337 FLD0361 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.124 2554 QD no call 1634 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140043 FLD0337 FLD0361 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.119 3984 no call pass 8209 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140043 FLD0337 FLD0361 3_prime_UTR TP53 c.*36C>T chr17 7572891 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572891", "IGV") medium 0.141 3984 no call pass 11007 TP53_E00001757276_1 ENSG00000141510 11 of 11 22 FFPE GGGGT G/A GGAGG CMDL140043 FLD0337 FLD0361 3_prime_UTR TP53 c.*19C>T chr17 7572908 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572908", "IGV") low 0.110 2554 QD no call 1059 TP53_E00001757276_1 ENSG00000141510 11 of 11 39 FFPE GTGGG G/A AACAA CMDL140043 FLD0337 FLD0361 synonymous TP53 c.1104C>T c.1104C>T(p.%3D) caC/caT chr17 7573005 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573005", "IGV") low 0.072 1271 QD no call 208 TP53_E00001757276_1 ENSG00000141510 11 of 11 TP53_g.17913del 6 FFPE TTCAG G/A TGGCT CMDL140150 FLD0338 FLD0362 synonymous BRAF c.1789C>T c.1789C>T(p.%3D) Cta/Tta chr7 140453146 G A =hyperlink("http://localhost:60151/goto?locus=chr7:140453146", "IGV") low 0.162 4421 QD no call 2774 BRAF_AA_HS ENSG00000157764 15 of 18 CM092080, rs121913369, COSM470 pathogenic 20 FFPE AGCTA G/A ACCAA CMDL140150 FLD0338 FLD0362 intron BRAF c.1742-35A>G chr7 140453228 T C =hyperlink("http://localhost:60151/goto?locus=chr7:140453228", "IGV") low 0.183 4421 QD no call 4826 BRAF_AA_HS ENSG00000157764 14 of 17 6 FFPE AGATC T/C CATTT CMDL140150 FLD0338 FLD0362 splice_region,intron EGFR c.2284-7C>T chr7 55248979 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248979", "IGV") low 1.000 2 no call LowQual 22 EGFR_E00001601336_1 ENSG00000146648 19 of 27 59 FFPE CCCTC C/T CTCCA CMDL140150 FLD0338 FLD0362 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") low 0.750 2 pass no call 42 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140150 FLD0338 FLD0362 synonymous EGFR c.2334G>A c.2334G>A(p.%3D) ctG/ctA chr7 55249036 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249036", "IGV") low 0.094 1514 QD no call 1167 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs397517118, COSM22941 uncertain_significance 15 FFPE CTGCT G/A GGCAT CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2335G>A p.G779S Ggc/Agc chr7 55249037 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249037", "IGV") low 0.095 1514 QD no call 1183 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs397517119, COSM22942, COSM25016 deleterious(0.03) probably_damaging(1) uncertain_significance 16 FFPE TGCTG G/A GCATC CMDL140150 FLD0338 FLD0362 synonymous EGFR c.2352C>T c.2352C>T(p.%3D) tcC/tcT chr7 55249054 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249054", "IGV") medium 0.180 1754 no call pass 7856 EGFR_E00001601336_2 ENSG00000146648 20 of 28 33 FFPE ACCTC C/T ACCGT CMDL140150 FLD0338 FLD0362 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.410 0.993 1567 1803 pass pass 21750 117923 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140150 FLD0338 FLD0362 synonymous EGFR c.2367C>T c.2367C>T(p.%3D) atC/atT chr7 55249069 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249069", "IGV") medium 0.177 3358 no call pass 16092 EGFR_E00001601336_2 ENSG00000146648 20 of 28 48 FFPE CTCAT C/T ACGCA CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2375T>C p.L792P cTc/cCc chr7 55249077 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55249077", "IGV") medium 0.181 3358 no call pass 16083 EGFR_E00001601336_2 ENSG00000146648 20 of 28 COSM13190 deleterious(0) probably_damaging(1) 56 FFPE GCAGC T/C CATGC CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2380C>T p.P794S Ccc/Tcc chr7 55249082 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249082", "IGV") medium 0.178 3358 no call pass 16112 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs370289230 deleterious(0.03) probably_damaging(1) 61 FFPE TCATG C/T CCTTC CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2392C>T p.L798F Ctc/Ttc chr7 55249094 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249094", "IGV") medium 0.254 2998 pass no call 8464 EGFR_E00001601336_2 ENSG00000146648 20 of 28 COSM1235323, COSM13191 deleterious(0) probably_damaging(1) 73 FFPE GCTGC C/T TCCTG CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2453G>A p.C818Y tGt/tAt chr7 55249155 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249155", "IGV") medium 0.349 1654 no call pass 18860 EGFR_E00001601336_2 ENSG00000146648 20 of 28 COSM23611 deleterious(0) probably_damaging(1) 40 FFPE CTGGT G/A TGTGC CMDL140150 FLD0338 FLD0362 synonymous EGFR c.2457G>A c.2457G>A(p.%3D) gtG/gtA chr7 55249159 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249159", "IGV") medium 0.349 1607 no call pass 20309 EGFR_E00001601336_2 ENSG00000146648 20 of 28 rs56183713, COSM13400 likely_benign A:0.0002 36 FFPE TGTGT G/A CAGAT CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2461A>G p.I821V Atc/Gtc chr7 55249163 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55249163", "IGV") medium 0.164 1605 no call pass 5800 EGFR_E00001601336_2 ENSG00000146648 20 of 28 deleterious(0.02) probably_damaging(0.94) 32 FFPE TGCAG A/G TCGCA CMDL140150 FLD0338 FLD0362 intron EGFR c.2469+13G>A chr7 55249184 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249184", "IGV") medium 0.350 1605 no call pass 18668 EGFR_E00001601336_2 ENSG00000146648 20 of 27 rs764099332, COSM17569 11 FFPE GGGAA G/A GGAGA CMDL140150 FLD0338 FLD0362 intron EGFR c.2626-18A>C chr7 55260441 A C =hyperlink("http://localhost:60151/goto?locus=chr7:55260441", "IGV") medium 0.994 2713 pass no call 120980 EGFR_E00001631695_1 ENSG00000146648 21 of 27 54 FFPE GCCTC A/C TCTCT CMDL140150 FLD0338 FLD0362 stop_gained EGFR c.2680C>T p.Q894* Cag/Tag chr7 55260513 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260513", "IGV") medium 0.990 2713 pass no call 81346 EGFR_E00001631695_1 ENSG00000146648 22 of 28 40 FFPE CCCAC C/T AGAGT CMDL140150 FLD0338 FLD0362 synonymous EGFR c.2556G>A c.2556G>A(p.%3D) aaG/aaA chr7 55259498 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259498", "IGV") medium 0.467 4278 pass no call 37200 EGFR_E00001681524_1 ENSG00000146648 21 of 28 COSM53265 28 FFPE GTCAA G/A ATCAC CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2533G>A p.V845M Gtg/Atg chr7 55259475 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259475", "IGV") medium 0.270 1203 no call pass 4919 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM28931 deleterious(0) probably_damaging(0.996) 59 FFPE TACTG G/A TGAAA CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2570G>A p.G857E gGg/gAg chr7 55259512 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259512", "IGV") medium 0.278 1203 no call pass 4993 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM370916, COSM250050 deleterious(0) probably_damaging(1) 60 FFPE TTTTG G/A GCTGG CMDL140150 FLD0338 FLD0362 synonymous EGFR c.2577C>T c.2577C>T(p.%3D) gcC/gcT chr7 55259519 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259519", "IGV") medium 0.358 1203 no call pass 15231 EGFR_E00001681524_2 ENSG00000146648 21 of 28 53 FFPE CTGGC C/T AAACT CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2591C>T p.A864V gCg/gTg chr7 55259533 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259533", "IGV") medium 0.358 1203 no call pass 15374 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM219795, COSM26035 tolerated(0.25) probably_damaging(0.944) 39 FFPE GGGTG C/T GGAAG CMDL140150 FLD0338 FLD0362 intron EGFR c.3115-63C>T chr7 55269365 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269365", "IGV") medium 0.331 1882 no call pass 18490 EGFR_E00001773562_1 ENSG00000146648 25 of 27 11 FFPE GCATT C/T AGGAA CMDL140150 FLD0338 FLD0362 intron EGFR c.3115-26G>A chr7 55269402 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269402", "IGV") medium 0.323 3404 pass no call 15443 EGFR_E00001773562_1 ENSG00000146648 25 of 27 rs370814862 48 FFPE TCCAT G/A GGCAA CMDL140150 FLD0338 FLD0362 synonymous EGFR c.3126C>T c.3126C>T(p.%3D) agC/agT chr7 55269439 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269439", "IGV") medium 0.460 3720 no call pass 37480 EGFR_E00001773562_1 ENSG00000146648 26 of 28 56 FFPE ACCAG C/T AACAA CMDL140150 FLD0338 FLD0362 synonymous EGFR c.3135C>T c.3135C>T(p.%3D) tcC/tcT chr7 55269448 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269448", "IGV") medium 0.460 3720 no call pass 65587 EGFR_E00001773562_1 ENSG00000146648 26 of 28 COSM3923817 47 FFPE AATTC C/T ACCGT CMDL140150 FLD0338 FLD0362 synonymous EGFR c.3147C>T c.3147C>T(p.%3D) tgC/tgT chr7 55269460 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269460", "IGV") medium 0.464 3720 no call pass 65904 EGFR_E00001773562_1 ENSG00000146648 26 of 28 35 FFPE GCTTG C/T ATTGA CMDL140150 FLD0338 FLD0362 intron EGFR c.3162+12C>T chr7 55269487 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55269487", "IGV") medium 0.210 1849 no call pass 7764 EGFR_E00001773562_1 ENSG00000146648 26 of 27 8 FFPE ATGAA C/T ACCTT CMDL140150 FLD0338 FLD0362 splice_region,intron EGFR c.2702-3C>T chr7 55266407 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266407", "IGV") medium 0.437 1040 no call pass 15983 EGFR_E00001779947_1 ENSG00000146648 22 of 27 rs757467886 24 FFPE CCTCT C/T AGGGG CMDL140150 FLD0338 FLD0362 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") medium 1.000 0.439 2 1041 pass pass 57 17138 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2752A>G p.I918V Atc/Gtc chr7 55266460 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55266460", "IGV") medium 0.559 2093 no call pass 46035 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(0.99) 77 FFPE ACGGA A/G TCCCT CMDL140150 FLD0338 FLD0362 synonymous EGFR c.2769C>T c.2769C>T(p.%3D) atC/atT chr7 55266477 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266477", "IGV") medium 0.554 2093 no call pass 45768 EGFR_E00001779947_1 ENSG00000146648 23 of 28 75 FFPE GAGAT C/T TCCTC CMDL140150 FLD0338 FLD0362 synonymous EGFR c.2778C>T c.2778C>T(p.%3D) atC/atT chr7 55266486 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266486", "IGV") medium 0.438 2093 no call pass 18449 EGFR_E00001779947_1 ENSG00000146648 23 of 28 66 FFPE TCCAT C/T CTGGA CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2807C>T p.P936L cCa/cTa chr7 55266515 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266515", "IGV") low 0.204 2933 no call QD 3659 EGFR_E00001779947_2 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(1) 39 FFPE TCAGC C/T ACCCA CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2835G>A p.M945I atG/atA chr7 55266543 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266543", "IGV") low 0.118 2933 no call QD 5137 EGFR_E00001779947_2 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(0.999) 67 FFPE TACAT G/A ATCAT CMDL140150 FLD0338 FLD0362 splice_region,intron EGFR c.2848+3G>A chr7 55266559 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266559", "IGV") low 0.118 2933 no call QD 111 EGFR_E00001779947_2 ENSG00000146648 23 of 27 65 FFPE AGTGT G/A AGTGA CMDL140150 FLD0338 FLD0362 intron EGFR c.2848+11G>A chr7 55266567 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266567", "IGV") medium 0.378 3728 pass no call 29222 EGFR_E00001779947_2 ENSG00000146648 23 of 27 57 FFPE TGACT G/A GTGGG CMDL140150 FLD0338 FLD0362 intron EGFR c.2848+20G>A chr7 55266576 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266576", "IGV") medium 0.344 3728 pass no call 28735 EGFR_E00001779947_2 ENSG00000146648 23 of 27 48 FFPE GGTCT G/A TCCAC CMDL140150 FLD0338 FLD0362 intron EGFR c.2848+22C>T chr7 55266578 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55266578", "IGV") low 0.206 2933 no call QD 3524 EGFR_E00001779947_2 ENSG00000146648 23 of 27 46 FFPE TCTGT C/T CACAC CMDL140150 FLD0338 FLD0362 intron EGFR c.2848+44G>A chr7 55266600 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266600", "IGV") medium 0.165 3728 pass no call 9025 EGFR_E00001779947_2 ENSG00000146648 23 of 27 24 FFPE GCCTT G/A GTGGC CMDL140150 FLD0338 FLD0362 intron EGFR c.2849-45C>T chr7 55267964 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55267964", "IGV") medium 0.991 1689 pass no call 60218 EGFR_E00001790701_1 ENSG00000146648 23 of 27 6 FFPE CATTT C/T TTCCA CMDL140150 FLD0338 FLD0362 intron EGFR c.2849-17T>A chr7 55267992 T A =hyperlink("http://localhost:60151/goto?locus=chr7:55267992", "IGV") low 0.204 3883 no call QD 6206 EGFR_E00001790701_1 ENSG00000146648 23 of 27 34 FFPE TTTTT T/A CTCAT CMDL140150 FLD0338 FLD0362 splice_region,intron EGFR c.2849-6C>T chr7 55268003 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268003", "IGV") low 0.189 3883 no call QD 5223 EGFR_E00001790701_1 ENSG00000146648 23 of 27 rs56276816 45 FFPE TCCTT C/T CCCAG CMDL140150 FLD0338 FLD0362 splice_region,intron EGFR c.2849-5C>T chr7 55268004 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268004", "IGV") medium 0.984 3409 pass no call 105730 EGFR_E00001790701_1 ENSG00000146648 23 of 27 rs375877462 46 FFPE CCTTC C/T CCAGG CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2879A>G p.K960R aAg/aGg chr7 55268039 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55268039", "IGV") low 0.189 3883 no call QD 4963 EGFR_E00001790701_1 ENSG00000146648 24 of 28 tolerated(0.74) benign(0.084) 75 FFPE CCCAA A/G GTTCC CMDL140150 FLD0338 FLD0362 synonymous EGFR c.2904C>T c.2904C>T(p.%3D) ttC/ttT chr7 55268064 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268064", "IGV") medium 0.992 3409 pass no call 108010 EGFR_E00001790701_1 ENSG00000146648 24 of 28 COSM3412203, COSM39614 50 FFPE GAATT C/T TCCAA CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2924C>T p.P975L cCc/cTc chr7 55268084 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268084", "IGV") medium 0.412 1949 no call pass 26667 EGFR_E00001790701_1 ENSG00000146648 24 of 28 deleterious(0) probably_damaging(1) 30 FFPE AGACC C/T CCAGC CMDL140150 FLD0338 FLD0362 splice_region,intron EGFR c.2947-7G>A chr7 55268874 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268874", "IGV") medium 0.342 4447 pass no call 22185 EGFR_E00001801208_1 ENSG00000146648 24 of 27 50 FFPE TCTCT G/A CACCA CMDL140150 FLD0338 FLD0362 splice_region,intron EGFR c.2947-5A>G chr7 55268876 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55268876", "IGV") low 0.175 4447 QD no call 5749 EGFR_E00001801208_1 ENSG00000146648 24 of 27 rs758106039 52 FFPE TCTGC A/G CCAGG CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2953G>A p.E985K Gaa/Aaa chr7 55268887 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268887", "IGV") medium 0.236 4488 no call pass 10010 EGFR_E00001801208_1 ENSG00000146648 25 of 28 deleterious(0.01) benign(0.42) 63 FFPE GGGAT G/A AAAGA CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.2995C>T p.R999C Cgt/Tgt chr7 55268929 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268929", "IGV") medium 0.313 4447 pass no call 19818 EGFR_E00001801208_1 ENSG00000146648 25 of 28 deleterious(0) possibly_damaging(0.775) 39 FFPE TCTAC C/T GTGCC CMDL140150 FLD0338 FLD0362 synonymous EGFR c.3001C>T c.3001C>T(p.%3D) Ctg/Ttg chr7 55268935 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268935", "IGV") low 0.205 4488 no call QD 7305 EGFR_E00001801208_1 ENSG00000146648 25 of 28 33 FFPE GTGCC C/T TGATG CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.3006G>A p.M1002I atG/atA chr7 55268940 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268940", "IGV") medium 0.338 4447 pass no call 23689 EGFR_E00001801208_1 ENSG00000146648 25 of 28 tolerated(0.16) benign(0.002) 28 FFPE CTGAT G/A GATGA CMDL140150 FLD0338 FLD0362 synonymous EGFR c.3024C>T c.3024C>T(p.%3D) gaC/gaT chr7 55268958 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268958", "IGV") low 0.095 2203 no call QD 1227 EGFR_E00001801208_1 ENSG00000146648 25 of 28 rs747143752 10 FFPE ATGGA C/T GACGT CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.3028G>A p.V1010M Gtg/Atg chr7 55268962 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268962", "IGV") low 0.117 2171 no call QD 915 EGFR_E00001801208_1 ENSG00000146648 25 of 28 rs757699239 tolerated(0.43) benign(0.174) 6 FFPE ACGAC G/A TGGTG CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.3019A>G p.M1007V Atg/Gtg chr7 55268953 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55268953", "IGV") medium 0.489 4295 no call pass 39860 EGFR_E00001801208_2 ENSG00000146648 25 of 28 tolerated(0.11) benign(0.036) 15 FFPE AAGAC A/G TGGAC CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.3028G>A p.V1010M Gtg/Atg chr7 55268962 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55268962", "IGV") medium 0.237 4205 pass no call 10553 EGFR_E00001801208_2 ENSG00000146648 25 of 28 rs757699239 tolerated(0.43) benign(0.174) 24 FFPE ACGAC G/A TGGTG CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.3049C>T p.L1017F Ctc/Ttc chr7 55268983 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268983", "IGV") medium 0.126 4205 pass no call 9926 EGFR_E00001801208_2 ENSG00000146648 25 of 28 deleterious(0.01) probably_damaging(0.994) 45 FFPE AGTAC C/T TCATC CMDL140150 FLD0338 FLD0362 nonsynonymous EGFR c.3056C>T p.P1019L cCa/cTa chr7 55268990 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268990", "IGV") medium 0.128 4205 pass no call 9926 EGFR_E00001801208_2 ENSG00000146648 25 of 28 COSM747423 deleterious(0) probably_damaging(0.998) 52 FFPE CATCC C/T ACAGC CMDL140150 FLD0338 FLD0362 splice_donor EGFR c.3114+1G>A chr7 55269049 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269049", "IGV") low 0.180 4205 QD no call 4450 EGFR_E00001801208_2 ENSG00000146648 25 of 27 30 FFPE CTCTG G/A TATGA CMDL140150 FLD0338 FLD0362 splice_region,intron EGFR c.3114+5G>A chr7 55269053 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269053", "IGV") medium 0.230 4205 pass no call 10344 EGFR_E00001801208_2 ENSG00000146648 25 of 27 26 FFPE GGTAT G/A AAATC CMDL140150 FLD0338 FLD0362 intron EGFR c.2185-13C>T chr7 55242402 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55242402", "IGV") low 0.153 4850 no call QD 2328 EGFR_Exon19 ENSG00000146648 18 of 27 rs377247228 8 FFPE CTTCT C/T TCTCT CMDL140150 FLD0338 FLD0362 intron EGFR c.2185-11C>T chr7 55242404 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55242404", "IGV") low 0.139 4850 no call QD 1019 EGFR_Exon19 ENSG00000146648 18 of 27 10 FFPE TCTCT C/T TCTGT CMDL140150 FLD0338 FLD0362 intron TP53 c.96+12G>A chr17 7579688 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579688", "IGV") low 0.500 2 no call pass 63 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs779577884 47 FFPE CCAAC C/T CTTGT CMDL140150 FLD0338 FLD0362 synonymous TP53 c.133C>T c.133C>T(p.%3D) Ctg/Ttg chr17 7579554 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579554", "IGV") medium 0.224 4010 no call pass 10264 EXP0116_TP53_E4 ENSG00000141510 4 of 11 TP53_g.11364C>T, TP53_g.11364C>A 53 FFPE GGACA G/A CATCA CMDL140150 FLD0338 FLD0362 intron KRAS c.111+10G>A chr12 25398198 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398198", "IGV") medium 0.229 4594 pass no call 10139 KRAS_AA_HS ENSG00000133703 2 of 5 rs755397559 15 FFPE TAAAA C/T AAGAT CMDL140150 FLD0338 FLD0362 nonsynonymous KRAS c.104C>T p.T35I aCa/aTa chr12 25398215 G A =hyperlink("http://localhost:60151/goto?locus=chr12:25398215", "IGV") low 0.177 4349 no call QD 3518 KRAS_AA_HS ENSG00000133703 2 of 6 COSM14208 deleterious(0.03) probably_damaging(0.913) 32 FFPE CTATT G/A TTGGA CMDL140150 FLD0338 FLD0362 nonsynonymous KRAS c.44G>A p.G15D gGc/gAc chr12 25398275 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398275", "IGV") low 0.177 4349 no call QD 4758 KRAS_AA_HS ENSG00000133703 2 of 6 COSM328030, COSM539 deleterious(0) probably_damaging(0.996) 35 FFPE TCTTG C/T CTACG CMDL140150 FLD0338 FLD0362 synonymous KRAS c.39C>T c.39C>T(p.%3D) ggC/ggT chr12 25398280 G A =hyperlink("http://localhost:60151/goto?locus=chr12:25398280", "IGV") low 0.159 4349 no call QD 1743 KRAS_AA_HS ENSG00000133703 2 of 6 rs397517040, COSM535, COSM536, COSM537, COSM1152503 likely_pathogenic 30 FFPE CCTAC G/A CCACC CMDL140150 FLD0338 FLD0362 nonsynonymous PIK3CA c.3136G>A p.A1046T Gca/Aca chr3 178952081 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178952081", "IGV") medium 0.508 4158 no call pass 41110 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 COSM27273 deleterious(0) probably_damaging(1) 24 FFPE ATGAT G/A CACAT CMDL140150 FLD0338 FLD0362 nonsynonymous PIK3CA c.3145G>A p.G1049S Ggt/Agt chr3 178952090 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178952090", "IGV") low 0.147 4604 QD no call 1057 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 rs121913277, COSM12597, COSM777, COSM1168056, COSM446029, COSM1421012 tolerated(0.06) probably_damaging(0.958) 33 FFPE ATCAT G/A GTGGC CMDL140150 FLD0338 FLD0362 3_prime_UTR PIK3CA c.*44G>A chr3 178952196 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178952196", "IGV") medium 0.177 2282 pass no call 8526 PIK3CA_Exn21_gap ENSG00000121879 21 of 21 12 FFPE ACACT G/A CACTG CMDL140150 FLD0338 FLD0362 intron PTEN c.802-9T>C chr10 89720642 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720642", "IGV") medium 0.017 127 pass no call 519 PTEN_E00001156315_1m ENSG00000171862 7 of 8 43 FFPE TTTTT T/C TTTTT CMDL140150 FLD0338 FLD0362 nonsynonymous PTEN c.844G>A p.G282R Gga/Aga chr10 89720693 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720693", "IGV") low 0.244 2716 no call MQRankSum 9001 PTEN_E00001156315_5 ENSG00000171862 8 of 9 COSM1349599 tolerated(0.14) benign(0.043) 18 FFPE TACCA G/A GACCA CMDL140150 FLD0338 FLD0362 nonsynonymous PTEN c.845G>A p.G282E gGa/gAa chr10 89720694 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720694", "IGV") low 0.127 2716 no call QD 249 PTEN_E00001156315_5 ENSG00000171862 8 of 9 tolerated(0.52) benign(0.008) 19 FFPE ACCAG G/A ACCAG CMDL140150 FLD0338 FLD0362 nonsynonymous PTEN c.878G>A p.G293E gGa/gAa chr10 89720727 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720727", "IGV") low 0.138 2716 no call MQRankSum,QD 1379 PTEN_E00001156315_5 ENSG00000171862 8 of 9 COSM28914, COSM1349605 deleterious(0.04) benign(0.315) 45 FFPE AAATG G/A AAGTC CMDL140150 FLD0338 FLD0362 nonsynonymous PTEN c.881G>A p.S294N aGt/aAt chr10 89720730 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720730", "IGV") low 0.132 0.393 3080 2716 QD MQRankSum 187 20745 PTEN_E00001156315_5 ENSG00000171862 8 of 9 COSM1717478 tolerated(0.2) benign(0.008) 42 FFPE TGGAA G/A TCTAT CMDL140150 FLD0338 FLD0362 nonsynonymous PTEN c.901G>A p.D301N Gat/Aat chr10 89720750 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720750", "IGV") medium 0.240 3080 pass no call 7599 PTEN_E00001156315_5 ENSG00000171862 8 of 9 rs758644748, COSM921144 tolerated(0.35) benign(0.002) 22 FFPE AAATC G/A ATAGC CMDL140150 FLD0338 FLD0362 splice_region,intron PTEN c.635-4G>A chr10 89717606 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717606", "IGV") medium 0.715 3808 no call pass 64981 PTEN_E00001156321_1 ENSG00000171862 6 of 8 COSM1577267 36 FFPE ACCAT G/A CAGAT CMDL140150 FLD0338 FLD0362 synonymous PTEN c.651C>T c.651C>T(p.%3D) gtC/gtT chr10 89717626 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717626", "IGV") medium 0.659 4170 pass no call 60479 PTEN_E00001156321_1 ENSG00000171862 7 of 9 COSM921122 56 FFPE GTGGT C/T TGCCA CMDL140150 FLD0338 FLD0362 nonsynonymous PTEN c.670A>G p.I224V Ata/Gta chr10 89717645 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717645", "IGV") medium 0.318 4170 pass no call 19739 PTEN_E00001156321_1 ENSG00000171862 7 of 9 tolerated(0.28) benign(0.173) 62 FFPE TGAAG A/G TATAT CMDL140150 FLD0338 FLD0362 synonymous PTEN c.714C>T c.714C>T(p.%3D) ttC/ttT chr10 89717689 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717689", "IGV") medium 0.288 3808 no call pass 11962 PTEN_E00001156321_1 ENSG00000171862 7 of 9 COSM1349578 18 FFPE AAGTT C/T ATGTA CMDL140150 FLD0338 FLD0362 intron PTEN c.801+142C>T chr10 89717918 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717918", "IGV") medium 0.994 1845 pass no call 77838 PTEN_E00001156321_4m ENSG00000171862 7 of 8 16 FFPE TGAGA C/T ATTAT CMDL140150 FLD0338 FLD0362 intron PTEN c.493-29T>C chr10 89711846 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89711846", "IGV") low 0.207 4336 QD no call 5097 PTEN_E00001156327_1 ENSG00000171862 5 of 8 51 FFPE TCAAT T/C TGGCT CMDL140150 FLD0338 FLD0362 intron PTEN c.493-22C>T chr10 89711853 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89711853", "IGV") low 0.180 3214 no call QD 2626 PTEN_E00001156327_1 ENSG00000171862 5 of 8 58 FFPE GGCTT C/T TCTTT CMDL140150 FLD0338 FLD0362 nonsynonymous PTEN c.301A>G p.I101V Atc/Gtc chr10 89692817 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89692817", "IGV") low 0.178 4047 no call QD 3790 PTEN_E00001156330_1 ENSG00000171862 5 of 9 deleterious(0.03) benign(0.31) 50 FFPE AACTT A/G TCAAA CMDL140150 FLD0338 FLD0362 nonsynonymous PTEN c.322C>T p.L108F Ctt/Ttt chr10 89692838 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692838", "IGV") low 0.160 4047 no call QD 1879 PTEN_E00001156330_1 ENSG00000171862 5 of 9 deleterious(0.01) possibly_damaging(0.889) 61 FFPE AAGAT C/T TTGAC CMDL140150 FLD0338 FLD0362 nonsynonymous PTEN c.442G>A p.A148T Gca/Aca chr10 89692958 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692958", "IGV") medium 0.991 2674 pass no call 76354 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5071, COSM1561206 tolerated(0.06) benign(0.394) 67 FFPE TAAAG G/A CACAA CMDL140150 FLD0338 FLD0362 nonsynonymous PTEN c.178A>G p.K60E Aag/Gag chr10 89685283 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89685283", "IGV") medium 0.355 4412 pass no call 23790 PTEN_E00001156344_1 ENSG00000171862 3 of 9 COSM6229 deleterious(0.01) possibly_damaging(0.688) 56 FFPE ATTCA A/G AGCAT CMDL140150 FLD0338 FLD0362 nonsynonymous PTEN c.1105G>A p.V369I Gtt/Att chr10 89725122 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89725122", "IGV") medium 0.262 4295 no call pass 12151 PTEN_E00001456541_2 ENSG00000171862 9 of 9 rs587782224 tolerated(0.4) benign(0.007) uncertain_significance 34 FFPE CAGAT G/A TTAGT CMDL140150 FLD0338 FLD0362 synonymous PTEN c.1125T>C c.1125T>C(p.%3D) gaT/gaC chr10 89725142 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89725142", "IGV") medium 0.266 4547 pass no call 13106 PTEN_E00001456541_2 ENSG00000171862 9 of 9 54 FFPE CCTGA T/C CATTA CMDL140150 FLD0338 FLD0362 synonymous PTEN c.1209C>T c.1209C>T(p.%3D) gtC/gtT chr10 89725226 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89725226", "IGV") medium 0.382 2207 no call pass 27194 PTEN_E00001456541_2 ENSG00000171862 9 of 9 15 FFPE AAAGT C/T TGAAT CMDL140150 FLD0338 FLD0362 5_prime_UTR PTEN c.-7C>T chr10 89624220 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624220", "IGV") medium 0.306 1167 no call pass 13047 PTEN_E00001456562_1 ENSG00000171862 1 of 9 26 FFPE AGGCT C/T CCAGA CMDL140150 FLD0338 FLD0362 nonsynonymous PTEN c.71A>G p.D24G gAc/gGc chr10 89624297 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89624297", "IGV") medium 0.251 2447 no call pass 5192 PTEN_E00001456562_1 ENSG00000171862 1 of 9 CM110138, COSM5107, COSM4016448 deleterious(0) possibly_damaging(0.761) 56 FFPE CTTAG A/G CTTGA CMDL140150 FLD0338 FLD0362 intron PTEN c.79+37G>A chr10 89624342 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89624342", "IGV") low 0.107 1289 no call QD 1563 PTEN_E00001456562_1 ENSG00000171862 1 of 8 11 FFPE TTTCT G/A TCACT CMDL140150 FLD0338 FLD0362 intron TP53 c.993+244G>A chr17 7576609 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576609", "IGV") low 0.173 4347 QD no call 2184 TP53_00001404886_13 ENSG00000141510 9 of 10 rs576532147 A:0.0002 2 FFPE AGAAC C/T ATTTT CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.665C>T p.P222L cCg/cTg chr17 7578184 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578184", "IGV") medium 0.256 1955 pass no call 5692 TP53_E00001255919_1 ENSG00000141510 6 of 11 CM103211, rs146340390, TP53_g.12734C>T, TP53_g.12734C>G, TP53_g.12734C>A, COSM44606, COSM46411, COSM1626225, COSM1626226, COSM1626227, COSM1626228 tolerated(0.19) benign(0.057) uncertain_significance,likely_benign 69 FFPE CAGGC G/A GCTCA CMDL140150 FLD0338 FLD0362 synonymous TP53 c.657C>T c.657C>T(p.%3D) ccC/ccT chr17 7578192 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578192", "IGV") medium 0.523 2239 no call pass 22875 TP53_E00001255919_1 ENSG00000141510 6 of 11 TP53_g.12726C>A, TP53_g.12726C>T, TP53_g.12726C>G, COSM1386663, COSM44689, COSM44799, COSM1386664, COSM1386665, COSM1386667, COSM1386666 61 FFPE TCATA G/A GGCAC CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.592G>A p.E198K Gaa/Aaa chr17 7578257 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578257", "IGV") medium 0.198 3038 pass no call 7115 TP53_E00001255919_3 ENSG00000141510 6 of 11 TP53_g.12661G>T, TP53_g.12661G>C, TP53_g.12661del, TP53_g.12661G>A, COSM45449, COSM43690, COSM44241, COSM44702, COSM118013, COSM391541, COSM118010, COSM391542, COSM118011, COSM391544, COSM3522696, COSM1750370, COSM118012, COSM391543 deleterious(0) probably_damaging(1) 8 FFPE TCCTT C/T CACTC CMDL140150 FLD0338 FLD0362 stop_gained TP53 c.586C>T p.R196* Cga/Tga chr17 7578263 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578263", "IGV") low 0.170 4624 no call QD 6348 TP53_E00001255919_3 ENSG00000141510 6 of 11 CM941329, rs397516435, TP53_g.12655del, TP53_g.12655C>G, TP53_g.12655C>A, TP53_g.12655C>T, COSM10705, COSM44757, COSM44615, COSM99668, COSM166215, COSM99665, COSM166214, COSM99666, COSM166216, COSM3378446, COSM1640847, COSM1735837, COSM99667, COSM166217 pathogenic 14 FFPE CACTC G/A GATAA CMDL140150 FLD0338 FLD0362 synonymous TP53 c.585C>T c.585C>T(p.%3D) atC/atT chr17 7578264 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578264", "IGV") medium 0.171 3045 pass no call 6123 TP53_E00001255919_3 ENSG00000141510 6 of 11 TP53_g.12654del, TP53_g.12654C>T, COSM562637, COSM562638, COSM562639, COSM562641, COSM1649392, COSM562640 15 FFPE ACTCG G/A ATAAG CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.568C>T p.P190S Cct/Tct chr17 7578281 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578281", "IGV") low 0.169 3045 QD no call 6057 TP53_E00001255919_3 ENSG00000141510 6 of 11 TP53_g.12637C>A, TP53_g.12637C>T, TP53_g.12637del, TP53_g.12637C>G, COSM44438, COSM44682, COSM44426, COSM44936, COSM1736075, COSM1736077, COSM1736079, COSM1736076, COSM1736078 deleterious(0.04) probably_damaging(0.995) 32 FFPE AGGAG G/A GGCCA CMDL140150 FLD0338 FLD0362 synonymous TP53 c.567C>T c.567C>T(p.%3D) gcC/gcT chr17 7578282 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578282", "IGV") low 0.171 4624 no call QD 6417 TP53_E00001255919_3 ENSG00000141510 6 of 11 rs55764374, TP53_g.12636C>T, COSM45440, COSM1564179, COSM1564180, COSM1564181, COSM1564183, COSM1564182 33 FFPE GGAGG G/A GCCAG CMDL140150 FLD0338 FLD0362 splice_acceptor TP53 c.560-1G>A chr17 7578290 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578290", "IGV") medium 0.204 3045 pass no call 7729 TP53_E00001255919_3 ENSG00000141510 5 of 10 CD043957, CS011574, CS083991, TP53_g.12628G>A, TP53_g.12628del, TP53_g.12628G>T, TP53_g.12628G>C, COSM43753, COSM43872, COSM43841, COSM45366, COSM341763, COSM127200, COSM335063, COSM341764, COSM127201, COSM335064, COSM127203, COSM341766, COSM335066, COSM4139869, COSM3717656, COSM1649389, COSM1649388, COSM127202, COSM335065, COSM341765 41 FFPE CAGAC C/T TAAGA CMDL140150 FLD0338 FLD0362 intron TP53 c.560-16C>T chr17 7578305 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578305", "IGV") medium 0.152 3045 pass no call 13153 TP53_E00001255919_3 ENSG00000141510 5 of 10 56 FFPE TCAGT G/A AGGAA CMDL140150 FLD0338 FLD0362 intron TP53 c.560-18C>T chr17 7578307 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578307", "IGV") medium 0.152 3045 pass no call 13153 TP53_E00001255919_3 ENSG00000141510 5 of 10 58 FFPE AGTGA G/A GAATC CMDL140150 FLD0338 FLD0362 intron TP53 c.559+30G>A chr17 7578341 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578341", "IGV") medium 0.201 3045 pass no call 6903 TP53_E00001255919_3 ENSG00000141510 5 of 10 49 FFPE CCAGC C/T CTGTC CMDL140150 FLD0338 FLD0362 intron TP53 c.559+29G>A chr17 7578342 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578342", "IGV") medium 0.237 3045 pass no call 11917 TP53_E00001255919_3 ENSG00000141510 5 of 10 48 FFPE CAGCC C/T TGTCG CMDL140150 FLD0338 FLD0362 stop_gained TP53 c.499C>T p.Q167* Cag/Tag chr17 7578431 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578431", "IGV") medium 0.382 2615 no call pass 16246 TP53_E00001255919_5 ENSG00000141510 5 of 11 CM942118, TP53_g.12487del, TP53_g.12487C>A, TP53_g.12487C>G, TP53_g.12487C>T, COSM11333, COSM44336, COSM46066, COSM44800, COSM121081, COSM121082, COSM121084, COSM3937613, COSM2744872, COSM121083 53 FFPE GTGCT G/A TGACT CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.466C>T p.R156C Cgc/Tgc chr17 7578464 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578464", "IGV") medium 0.324 2948 pass no call 18379 TP53_E00001255919_5 ENSG00000141510 5 of 11 rs563378859, TP53_g.12454C>T, TP53_g.12454C>A, TP53_g.12454C>G, TP53_g.12454del, COSM45154, COSM43744, COSM45896, COSM46124, COSM3403271, COSM3403274, COSM3403276, COSM3403273, COSM3403272, COSM3403275 tolerated(0.19) benign(0.402) uncertain_significance 45 FFPE GACGC G/A GGTGC CMDL140150 FLD0338 FLD0362 synonymous TP53 c.465C>T c.465C>T(p.%3D) acC/acT chr17 7578465 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578465", "IGV") medium 0.325 2948 pass no call 18484 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12453C>T, TP53_g.12453C>A, TP53_g.12453del, COSM43670, COSM44619, COSM43691, COSM437579, COSM437580, COSM437582, COSM437581 44 FFPE ACGCG G/A GTGCC CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.452C>T p.P151L cCc/cTc chr17 7578478 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578478", "IGV") medium 0.402 2615 no call pass 17356 TP53_E00001255919_5 ENSG00000141510 5 of 11 TP53_g.12440C>A, TP53_g.12440C>T, TP53_g.12440C>G, COSM44003, COSM44288, COSM11476, COSM259150, COSM707868, COSM259149, COSM707869, COSM259151, COSM707871, COSM4139888, COSM3388218, COSM4139887, COSM2744918, COSM259152, COSM707870 deleterious(0.02) probably_damaging(0.998) 31 FFPE GCGGG G/A GTGTG CMDL140150 FLD0338 FLD0362 synonymous TP53 c.420C>T c.420C>T(p.%3D) acC/acT chr17 7578510 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578510", "IGV") low 0.206 3758 QD no call 7290 TP53_E00001255919_6 ENSG00000141510 5 of 11 TP53_g.12408C>A, TP53_g.12408C>T, COSM69019, COSM44706 64 FFPE GGGCA G/A GTCTT CMDL140150 FLD0338 FLD0362 intron TP53 c.376-10C>T chr17 7578564 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578564", "IGV") low 0.208 3758 QD no call 6885 TP53_E00001255919_6 ENSG00000141510 4 of 10 TP53_g.12354C>T, COSM46116 10 FFPE AGGAA G/A AGGAA CMDL140150 FLD0338 FLD0362 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") medium 0.291 0.960 689 49 pass pass 2812 1039 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140150 FLD0338 FLD0362 intron TP53 c.74+26G>A chr17 7579813 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579813", "IGV") low 0.960 49 no call pass 1069 TP53_E00001596491_1 ENSG00000141510 2 of 10 36 FFPE GTGGG C/T CTGCC CMDL140150 FLD0338 FLD0362 splice_region,synonymous TP53 c.73C>T c.73C>T(p.%3D) Cta/Tta chr17 7579840 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579840", "IGV") medium 0.241 689 pass no call 2042 TP53_E00001596491_1 ENSG00000141510 2 of 11 63 FFPE TCACA G/A TTTCC CMDL140150 FLD0338 FLD0362 splice_region,intron TP53 c.375+3C>T chr17 7579309 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579309", "IGV") medium 0.266 3416 pass no call 11279 TP53_E00001612188_1 ENSG00000141510 4 of 10 TP53_g.11609C>T, COSM44049 30 FFPE CAACT G/A ACCGT CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.329G>A p.R110H cGt/cAt chr17 7579358 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579358", "IGV") low 0.131 3892 no call QD 1825 TP53_E00001612188_1 ENSG00000141510 4 of 11 CM984590, CM115383, TP53_g.11560G>A, TP53_g.11560G>T, TP53_g.11560del, TP53_g.11560G>C, COSM10716, COSM43805, COSM11250, COSM46115, COSM99929, COSM1166752, COSM2745016, COSM2745018, COSM99928, COSM1166753, COSM3723935, COSM3388234, COSM2745017, COSM1646883 tolerated(0.2) benign(0.102) 48 FFPE CCAGA C/T GGAAA CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.317G>A p.S106N aGc/aAc chr17 7579370 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579370", "IGV") medium 0.133 3892 no call pass 10395 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11548del, COSM46201 tolerated(0.5) benign(0.001) 36 FFPE CGTAG C/T TGCCC CMDL140150 FLD0338 FLD0362 stop_gained TP53 c.310C>T p.Q104* Cag/Tag chr17 7579377 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579377", "IGV") medium 0.243 3416 pass no call 8611 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11541C>T, TP53_g.11541del, COSM10886, COSM308172, COSM308171, COSM3727867, COSM2745029 29 FFPE GCCCT G/A GTAGG CMDL140150 FLD0338 FLD0362 synonymous TP53 c.297C>T c.297C>T(p.%3D) tcC/tcT chr17 7579390 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579390", "IGV") medium 0.123 3892 no call pass 8833 TP53_E00001612188_1 ENSG00000141510 4 of 11 rs751494750, COSM1386878, COSM1386879, COSM1386880 16 FFPE TTCTG G/A GAAGG CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.293C>T p.P98L cCt/cTt chr17 7579394 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579394", "IGV") medium 0.123 3892 no call pass 8833 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11524C>T, COSM44681 deleterious(0) probably_damaging(1) 12 FFPE GGGAA G/A GGACA CMDL140150 FLD0338 FLD0362 synonymous TP53 c.297C>T c.297C>T(p.%3D) tcC/tcT chr17 7579390 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579390", "IGV") low 0.174 147 no call QD 200 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs751494750, COSM1386878, COSM1386879, COSM1386880 13 FFPE TTCTG G/A GAAGG CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.293C>T p.P98L cCt/cTt chr17 7579394 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579394", "IGV") medium 0.211 147 no call pass 398 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11524C>T, COSM44681 deleterious(0) probably_damaging(1) 17 FFPE GGGAA G/A GGACA CMDL140150 FLD0338 FLD0362 synonymous TP53 c.277C>T c.277C>T(p.%3D) Ctg/Ttg chr17 7579410 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579410", "IGV") low 0.188 155 QD no call 274 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11508C>A, TP53_g.11508C>T, COSM166218, COSM1564163, COSM96581, COSM43812, COSM1564164, COSM166220, COSM166219, COSM1564165 33 FFPE TGACA G/A GGGCC CMDL140150 FLD0338 FLD0362 synonymous TP53 c.276C>T c.276C>T(p.%3D) ccC/ccT chr17 7579411 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579411", "IGV") medium 0.463 155 pass no call 2790 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11507C>T 34 FFPE GACAG G/A GGCCA CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.274C>T p.P92S Ccc/Tcc chr17 7579413 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579413", "IGV") medium 0.463 155 pass no call 2781 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11505del, TP53_g.11505C>G, TP53_g.11505C>T, COSM45844, COSM45290 deleterious(0.02) benign(0.398) 36 FFPE CAGGG G/A CCAGG CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.266C>T p.P89L cCc/cTc chr17 7579421 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579421", "IGV") medium 0.463 155 pass no call 2790 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs730881994, TP53_g.11497C>T, COSM44677 tolerated(0.1) benign(0.007) uncertain_significance 44 FFPE AGGAG G/A GGGCT CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.265C>T p.P89S Ccc/Tcc chr17 7579422 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579422", "IGV") low 0.125 155 QD no call 42 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11496C>T, TP53_g.11496del, COSM43688, COSM46063 tolerated(0.52) benign(0.017) 45 FFPE GGAGG G/A GGCTG CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.538 0.926 155 147 pass pass 1900 3686 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140150 FLD0338 FLD0362 intron TP53 c.782+41C>T chr17 7577458 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577458", "IGV") medium 0.535 1007 no call pass 19643 TP53_E00001665758_1 ENSG00000141510 7 of 10 rs767784839 9 FFPE CTGGG G/A CACAG CMDL140150 FLD0338 FLD0362 intron TP53 c.782+15G>A chr17 7577484 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577484", "IGV") medium 0.466 2019 no call pass 17257 TP53_E00001665758_1 ENSG00000141510 7 of 10 35 FFPE GGTGG C/T AAGTG CMDL140150 FLD0338 FLD0362 synonymous TP53 c.702C>T c.702C>T(p.%3D) taC/taT chr17 7577579 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577579", "IGV") medium 0.524 2006 no call pass 20938 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13339C>G, TP53_g.13339C>T, TP53_g.13339C>A, COSM45114, COSM45470, COSM1630412, COSM44785, COSM1324800, COSM1630413, COSM1600318, COSM1386634, COSM1386635, COSM1630414, COSM1324801, COSM1600319, COSM1630415, COSM1324802, COSM1600320, COSM1386636 33 FFPE TAGTT G/A TAGTG CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.1063G>A p.A355T Gct/Act chr17 7573964 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573964", "IGV") medium 0.988 1987 pass no call 58745 TP53_E00001728015_1 ENSG00000141510 10 of 11 tolerated(0.23) benign(0.042) 73 FFPE CCCAG C/T CTGGG CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.1036G>A p.E346K Gag/Aag chr17 7573991 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7573991", "IGV") medium 0.994 1987 pass no call 59141 TP53_E00001728015_1 ENSG00000141510 10 of 11 TP53_g.16927G>T, COSM44083, COSM1522201 deleterious(0.01) probably_damaging(0.952) 46 FFPE GGCCT C/T ATTCA CMDL140150 FLD0338 FLD0362 3_prime_UTR TP53 c.*36C>T chr17 7572891 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572891", "IGV") medium 0.834 3499 no call pass 83391 TP53_E00001757276_1 ENSG00000141510 11 of 11 22 FFPE GGGGT G/A GGAGG CMDL140150 FLD0338 FLD0362 3_prime_UTR TP53 c.*21C>T chr17 7572906 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572906", "IGV") medium 0.827 3499 no call pass 82801 TP53_E00001757276_1 ENSG00000141510 11 of 11 37 FFPE CAGTG G/A GGAAC CMDL140150 FLD0338 FLD0362 intron TP53 c.993+31G>A chr17 7576822 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576822", "IGV") medium 0.325 2578 no call pass 26652 TP53_E00001789298_1 ENSG00000141510 9 of 10 16 FFPE ACTTT C/T CACTT CMDL140150 FLD0338 FLD0362 synonymous TP53 c.969G>A c.969G>A(p.%3D) ctG/ctA chr17 7576877 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576877", "IGV") low 0.500 2 LowQual no call 22 TP53_E00001789298_1 ENSG00000141510 9 of 11 rs672601297 not_provided 71 FFPE CCATC C/T AGTGG CMDL140150 FLD0338 FLD0362 splice_acceptor TP53 c.920-1G>A chr17 7576927 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576927", "IGV") medium 0.676 5088 no call pass 78825 TP53_E00001789298_1 ENSG00000141510 8 of 10 rs587781702, CS114009, CS0910927, TP53_g.13991G>C, TP53_g.13991G>T, TP53_g.13991G>A, COSM6917, COSM95740, COSM99956, COSM127198, COSM3701287, COSM2150608, COSM1726498 pathogenic 37 FFPE CAGTG C/T TAGGA CMDL140150 FLD0338 FLD0362 intron TP53 c.920-33C>T chr17 7576959 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576959", "IGV") low 0.140 3455 no call QD 1359 TP53_E00001789298_2 ENSG00000141510 8 of 10 34 FFPE AAAGT G/A AATCT CMDL140150 FLD0338 FLD0362 intron TP53 c.920-43G>A chr17 7576969 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576969", "IGV") medium 0.531 3455 no call pass 37521 TP53_E00001789298_2 ENSG00000141510 8 of 10 44 FFPE TGAGG C/T ATAAC CMDL140150 FLD0338 FLD0362 intron TP53 c.919+42G>A chr17 7576977 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7576977", "IGV") low 0.169 3560 QD no call 2798 TP53_E00001789298_2 ENSG00000141510 8 of 10 52 FFPE AACTG C/T ACCCT CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.916C>G p.R306G Cga/Gga chr17 7577022 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7577022", "IGV") low 0.166 3560 QD no call 2982 TP53_E00001789298_2 ENSG00000141510 8 of 11 CM971506, rs121913344, TP53_g.13896del, TP53_g.13896C>T, COSM10663, COSM44631, COSM99947, COSM3388168, COSM1640820 deleterious(0.02) probably_damaging(0.932) pathogenic 34 FFPE ACCTC G/C CTTAG CMDL140150 FLD0338 FLD0362 synonymous TP53 c.906G>A c.906G>A(p.%3D) ggG/ggA chr17 7577032 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577032", "IGV") low 0.141 3560 QD no call 670 TP53_E00001789298_2 ENSG00000141510 8 of 11 TP53_g.13886del, TP53_g.13886G>T, TP53_g.13886G>C, COSM46318, COSM45998, COSM45177 24 FFPE GTGCT C/T CCTGG CMDL140150 FLD0338 FLD0362 synonymous TP53 c.870C>T c.870C>T(p.%3D) cgC/cgT chr17 7577068 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577068", "IGV") medium 0.440 3309 pass no call 26071 TP53_E00001789298_3 ENSG00000141510 8 of 11 TP53_g.13850del, TP53_g.13850C>G, TP53_g.13850C>T, TP53_g.13850C>A, COSM45443, COSM44381, COSM44507, COSM1386593 46 FFPE TTCTT G/A CGGAG CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.845G>A p.R282Q cGg/cAg chr17 7577093 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577093", "IGV") medium 0.554 3309 pass no call 46898 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs730882008, CM004344, TP53_g.13825del, TP53_g.13825G>A, TP53_g.13825G>T, TP53_g.13825G>C, TP53_g.13825delinsCCC, COSM44306, COSM44338, COSM44470, COSM44468, COSM117157, COSM99936, COSM3712576, COSM3958798, COSM1646815, COSM3958797 deleterious(0) probably_damaging(0.941) 71 FFPE TGCGC C/T GGTCT CMDL140150 FLD0338 FLD0362 nonsynonymous TP53 c.841G>A p.D281N Gac/Aac chr17 7577097 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577097", "IGV") medium 0.531 3430 no call pass 36595 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs764146326, CM076566, TP53_g.13821G>T, TP53_g.13821G>A, TP53_g.13821G>C, COSM11516, COSM43596, COSM10943, COSM146336, COSM214193, COSM1158315, COSM3388352, COSM3932743, COSM3820706, COSM2152580, COSM1649341, COSM1646814 deleterious(0.01) probably_damaging(0.996) 70 FFPE CCGGT C/T TCTCC CMDL140150 FLD0338 FLD0362 synonymous TP53 c.816G>A c.816G>A(p.%3D) gtG/gtA chr17 7577122 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577122", "IGV") medium 0.558 3309 pass no call 41416 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs756421198, TP53_g.13796G>A, TP53_g.13796G>T, TP53_g.13796G>C, COSM44857, COSM45865, COSM44864, COSM417968 45 FFPE ACACG C/T ACCTC CMDL140152 FLD0339 FLD0363 intron EGFR c.2284-58T>C chr7 55248928 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55248928", "IGV") low 0.095 1597 QD no call 1273 EGFR_E00001601336_1 ENSG00000146648 19 of 27 8 FFPE CCATG T/C GCCCC CMDL140152 FLD0339 FLD0363 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.991 0.985 1548 1550 pass pass 58803 64172 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140152 FLD0339 FLD0363 synonymous EGFR c.2346C>T c.2346C>T(p.%3D) ctC/ctT chr7 55249048 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249048", "IGV") medium 0.150 1572 pass no call 5167 EGFR_E00001601336_2 ENSG00000146648 20 of 28 27 FFPE TGCCT C/T ACCTC CMDL140152 FLD0339 FLD0363 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.441 0.448 1640 1804 pass pass 22838 27645 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140152 FLD0339 FLD0363 intron EGFR c.2626-65G>A chr7 55260394 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260394", "IGV") medium 0.151 1964 pass no call 5222 EGFR_E00001631695_1 ENSG00000146648 21 of 27 7 FFPE AGTGA G/A TTAAC CMDL140152 FLD0339 FLD0363 synonymous EGFR c.2634C>T c.2634C>T(p.%3D) atC/atT chr7 55260467 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260467", "IGV") low 0.180 3915 QD no call 2635 EGFR_E00001631695_1 ENSG00000146648 22 of 28 rs757939047 80 FFPE CCTAT C/T AAGTG CMDL140152 FLD0339 FLD0363 intron EGFR c.2701+13C>T chr7 55260547 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55260547", "IGV") low 0.131 1951 QD no call 2973 EGFR_E00001631695_1 ENSG00000146648 22 of 27 6 FFPE ATAAT C/T CTGAT CMDL140152 FLD0339 FLD0363 intron EGFR c.2701+16G>A chr7 55260550 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55260550", "IGV") medium 0.238 2120 no call pass 13706 EGFR_E00001631695_1 ENSG00000146648 22 of 27 3 FFPE ATCCT G/A ATGCT CMDL140152 FLD0339 FLD0363 intron EGFR c.2470-11C>T chr7 55259401 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259401", "IGV") medium 0.298 3310 no call pass 14476 EGFR_E00001681524_1 ENSG00000146648 20 of 27 30 FFPE GTCTT C/T TCTGT CMDL140152 FLD0339 FLD0363 intron EGFR c.2470-9C>T chr7 55259403 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259403", "IGV") low 0.193 3310 no call QD 4548 EGFR_E00001681524_1 ENSG00000146648 20 of 27 32 FFPE CTTCT C/T TGTTT CMDL140152 FLD0339 FLD0363 synonymous EGFR c.2574G>A c.2574G>A(p.%3D) ctG/ctA chr7 55259516 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259516", "IGV") medium 0.216 1333 pass no call 2893 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs397517129, COSM133590 uncertain_significance 56 FFPE GGGCT G/A GCCAA CMDL140152 FLD0339 FLD0363 synonymous EGFR c.2592G>A c.2592G>A(p.%3D) gcG/gcA chr7 55259534 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55259534", "IGV") medium 0.414 1333 pass no call 10068 EGFR_E00001681524_2 ENSG00000146648 21 of 28 rs397517131, COSM1743240 likely_benign 38 FFPE GGTGC G/A GAAGA CMDL140152 FLD0339 FLD0363 nonsynonymous,splice_region EGFR c.3116G>A p.S1039N aGt/aAt chr7 55269429 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55269429", "IGV") low 0.134 4091 no call QD 2465 EGFR_E00001773562_1 ENSG00000146648 26 of 28 tolerated(0.14) possibly_damaging(0.901) 66 FFPE TCAGA G/A TGCAA CMDL140152 FLD0339 FLD0363 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.995 0.998 1473 1763 pass pass 63019 76030 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140152 FLD0339 FLD0363 nonsynonymous EGFR c.2974C>T p.P992S Cct/Tct chr7 55268908 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268908", "IGV") low 0.124 2984 no call QD 1684 EGFR_E00001801208_1 ENSG00000146648 25 of 28 tolerated(0.06) probably_damaging(0.994) 60 FFPE CAAGT C/T CTACA CMDL140152 FLD0339 FLD0363 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.473 0.463 3897 2984 pass pass 34555 32212 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL140152 FLD0339 FLD0363 intron TP53 c.96+17G>A chr17 7579683 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579683", "IGV") medium 0.857 854 pass no call 38164 EXP0116_TP53_E3 ENSG00000141510 3 of 10 52 FFPE CCAGC C/T CAACC CMDL140152 FLD0339 FLD0363 stop_gained TP53 c.112C>T p.Q38* Caa/Taa chr17 7579575 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579575", "IGV") low 0.149 3572 QD no call 1859 EXP0116_TP53_E4 ENSG00000141510 4 of 11 CM107390, TP53_g.11343C>T, TP53_g.11343del, COSM46286, COSM236890, COSM236889 32 FFPE TGCTT G/A GGACG CMDL140152 FLD0339 FLD0363 synonymous PIK3CA c.1584A>G c.1584A>G(p.%3D) aaA/aaG chr3 178936042 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178936042", "IGV") medium 0.266 1137 no call pass 3528 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 78 FFPE GACAA A/G GAACA CMDL140152 FLD0339 FLD0363 synonymous PIK3CA c.1650T>C c.1650T>C(p.%3D) ttT/ttC chr3 178936108 T C =hyperlink("http://localhost:60151/goto?locus=chr3:178936108", "IGV") medium 0.567 557 no call pass 11763 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 19 FFPE GATTT T/C CTATG CMDL140152 FLD0339 FLD0363 intron PTEN c.802-14T>C chr10 89720637 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720637", "IGV") low 0.063 201 no call QD 41 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs775342006 48 FFPE TCTTT T/C TTTTT CMDL140152 FLD0339 FLD0363 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") medium 0.040 201 no call pass 612 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL140152 FLD0339 FLD0363 nonsynonymous PTEN c.823G>A p.V275I Gta/Ata chr10 89720672 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720672", "IGV") medium 0.361 201 no call pass 2851 PTEN_E00001156315_1m ENSG00000171862 8 of 9 COSM921140, COSM5864 tolerated(0.34) benign(0.008) 13 FFPE TTTGG G/A TAAAT CMDL140152 FLD0339 FLD0363 nonsynonymous PTEN c.698G>A p.R233Q cGa/cAa chr10 89717673 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717673", "IGV") low 0.198 3717 QD no call 5244 PTEN_E00001156321_2 ENSG00000171862 7 of 9 rs770025422, COSM1297486 tolerated(0.12) benign(0.156) 34 FFPE CACAC G/A ACGGG CMDL140152 FLD0339 FLD0363 nonsynonymous PTEN c.736C>T p.P246S Ccg/Tcg chr10 89717711 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717711", "IGV") low 0.200 3740 no call QD 5745 PTEN_E00001156321_2 ENSG00000171862 7 of 9 tolerated(0.18) benign(0.06) 65 FFPE CTCAG C/T CGTTA CMDL140152 FLD0339 FLD0363 synonymous PTEN c.738G>A c.738G>A(p.%3D) ccG/ccA chr10 89717713 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717713", "IGV") low 0.155 3740 no call QD 1002 PTEN_E00001156321_2 ENSG00000171862 7 of 9 rs774364894, COSM5822, COSM921126 63 FFPE CAGCC G/A TTACC CMDL140152 FLD0339 FLD0363 nonsynonymous PTEN c.749G>A p.C250Y tGt/tAt chr10 89717724 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717724", "IGV") medium 0.129 3740 no call pass 8096 PTEN_E00001156321_2 ENSG00000171862 7 of 9 tolerated(0.42) benign(0.02) 52 FFPE TGTGT G/A TGGTG CMDL140152 FLD0339 FLD0363 nonsynonymous PTEN c.752G>A p.G251D gGt/gAt chr10 89717727 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717727", "IGV") medium 0.129 3740 no call pass 8096 PTEN_E00001156321_2 ENSG00000171862 7 of 9 COSM5286, COSM13981, COSM3967201 deleterious(0.03) possibly_damaging(0.831) 49 FFPE GTGTG G/A TGATA CMDL140152 FLD0339 FLD0363 nonsynonymous PTEN c.469G>A p.E157K Gaa/Aaa chr10 89692985 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692985", "IGV") medium 0.327 2973 pass no call 14282 PTEN_E00001156330_3 ENSG00000171862 5 of 9 rs121909220, CM971274, COSM921104, COSM1577254 tolerated(0.21) benign(0.115) pathogenic 40 FFPE ATGGG G/A AAGTA CMDL140152 FLD0339 FLD0363 nonsynonymous PTEN c.89C>T p.P30L cCa/cTa chr10 89653791 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653791", "IGV") low 0.201 3887 QD no call 5847 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM5799, COSM921059 deleterious(0.03) benign(0.358) 24 FFPE TTATC C/T AAACA CMDL140152 FLD0339 FLD0363 nonsynonymous PTEN c.140G>A p.R47K aGg/aAg chr10 89653842 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89653842", "IGV") medium 0.301 4055 no call pass 15974 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM921067, COSM428079 deleterious(0.02) probably_damaging(0.999) 55 FFPE ATACA G/A GAACA CMDL140152 FLD0339 FLD0363 intron PTEN c.79+35C>T chr10 89624340 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624340", "IGV") high 0.546 0.567 1408 1585 pass pass 22586 26359 PTEN_E00001456562_1 ENSG00000171862 1 of 8 rs190707033 uncertain_significance T:0.0010 13 FFPE CCTTT C/T TGTCA CMDL140152 FLD0339 FLD0363 intron TP53 c.672+25G>A chr17 7578152 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578152", "IGV") low 0.075 3048 no call QD 692 TP53_E00001255919_1 ENSG00000141510 6 of 10 TP53_g.12766G>A, TP53_g.12766G>C, COSM45996, COSM45559 43 FFPE CCTCC C/T AGAGA CMDL140152 FLD0339 FLD0363 nonsynonymous TP53 c.542G>A p.R181H cGc/cAc chr17 7578388 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578388", "IGV") low 0.154 2992 QD no call 364 TP53_E00001255919_5 ENSG00000141510 5 of 11 CM942120, rs397514495, CM056067, CM920671, TP53_g.12530G>A, TP53_g.12530G>T, TP53_g.12530del, TP53_g.12530G>C, COSM10738, COSM44152, COSM45046, COSM1386797, COSM99661, COSM1386798, COSM99658, COSM1386800, COSM99659, COSM3388202, COSM3388201, COSM99660, COSM1386799 deleterious(0.02) probably_damaging(0.977) likely_pathogenic,pathogenic,risk_factor 10 FFPE AGCAG C/T GCTCA CMDL140152 FLD0339 FLD0363 intron TP53 c.74+53C>T chr17 7579786 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579786", "IGV") medium 0.558 1295 no call pass 26901 TP53_E00001596491_1 ENSG00000141510 2 of 10 9 FFPE TAGGG G/A GCTGG CMDL140152 FLD0339 FLD0363 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.694 0.323 1869 2581 pass pass 30087 11325 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140152 FLD0339 FLD0363 nonsynonymous TP53 c.37C>T p.P13S Cct/Tct chr17 7579876 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579876", "IGV") medium 0.521 2581 no call pass 26796 TP53_E00001596491_1 ENSG00000141510 2 of 11 deleterious(0.05) possibly_damaging(0.687) 47 FFPE CAGAG G/A GGGCT CMDL140152 FLD0339 FLD0363 nonsynonymous TP53 c.221C>T p.A74V gCc/gTc chr17 7579466 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579466", "IGV") medium 0.214 186 pass no call 404 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs587781832, TP53_g.11452C>T, COSM43671 tolerated(0.4) benign(0.003) uncertain_significance 35 FFPE CAGGG G/A CCACG CMDL140152 FLD0339 FLD0363 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.835 0.833 186 216 pass pass 4279 4046 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140152 FLD0339 FLD0363 intron TP53 c.1100+36C>T chr17 7573891 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7573891", "IGV") low 0.102 1285 QD no call 1611 TP53_E00001728015_1 ENSG00000141510 10 of 10 11 FFPE AGGCA G/A GGGAG CMDL140152 FLD0339 FLD0363 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.476 3123 pass no call 34826 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140152 FLD0339 FLD0363 3_prime_UTR TP53 c.*39C>A chr17 7572888 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.176 3276 no call QD 4712 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/T GTGGG CMDL140152 FLD0339 FLD0363 3_prime_UTR TP53 c.*36C>T chr17 7572891 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572891", "IGV") low 0.179 3276 no call QD 5471 TP53_E00001757276_1 ENSG00000141510 11 of 11 22 FFPE GGGGT G/A GGAGG CMDL140152 FLD0339 FLD0363 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") medium 0.269 0.190 3123 3276 pass QD 13587 5684 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL140152 FLD0339 FLD0363 3_prime_UTR TP53 c.*24C>T chr17 7572903 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572903", "IGV") low 0.136 3276 no call QD 462 TP53_E00001757276_1 ENSG00000141510 11 of 11 34 FFPE TGTCA G/A TGGGG CMDL140152 FLD0339 FLD0363 3_prime_UTR TP53 c.*21C>T chr17 7572906 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572906", "IGV") medium 0.380 3276 no call pass 29122 TP53_E00001757276_1 ENSG00000141510 11 of 11 37 FFPE CAGTG G/A GGAAC CMDL140152 FLD0339 FLD0363 synonymous TP53 c.1113C>T c.1113C>T(p.%3D) tcC/tcT chr17 7572996 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572996", "IGV") medium 0.253 3123 pass no call 11604 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs765530090 15 FFPE TTTTT G/A GACTT CMDL140152 FLD0339 FLD0363 nonsynonymous TP53 c.797G>A p.G266E gGa/gAa chr17 7577141 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577141", "IGV") low 0.155 3414 QD no call 1330 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs193920774, TP53_g.13777G>C, TP53_g.13777del, TP53_g.13777G>T, TP53_g.13777G>A, COSM10958, COSM44187, COSM10867, COSM45488, COSM216410, COSM99952, COSM3388173, COSM3388174, COSM1679491, COSM1646803 deleterious(0) probably_damaging(0.999) uncertain_significance 26 FFPE TCCGT C/T CCAGT CMDL140158 FLD0340 FLD0364 intron EGFR c.2284-55C>T chr7 55248931 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248931", "IGV") medium 0.300 1620 no call pass 19655 EGFR_E00001601336_1 ENSG00000146648 19 of 27 11 FFPE TGTGC C/T CCTCC CMDL140158 FLD0340 FLD0364 splice_region,intron EGFR c.2284-3C>T chr7 55248983 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248983", "IGV") medium 0.295 3525 no call pass 15892 EGFR_E00001601336_1 ENSG00000146648 19 of 27 63 FFPE CCCTC C/T AGGAA CMDL140158 FLD0340 FLD0364 synonymous EGFR c.2310C>T c.2310C>T(p.%3D) gaC/gaT chr7 55249012 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249012", "IGV") low 0.191 3525 no call QD 4437 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs397517110 likely_benign 81 FFPE GTGGA C/T AACCC CMDL140158 FLD0340 FLD0364 synonymous EGFR c.2352C>T c.2352C>T(p.%3D) tcC/tcT chr7 55249054 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249054", "IGV") medium 0.212 1916 no call pass 10777 EGFR_E00001601336_1 ENSG00000146648 20 of 28 39 FFPE ACCTC C/T ACCGT CMDL140158 FLD0340 FLD0364 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.395 0.576 1987 1905 pass pass 25724 41542 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140158 FLD0340 FLD0364 nonsynonymous EGFR c.2374C>T p.L792F Ctc/Ttc chr7 55249076 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249076", "IGV") medium 0.209 1905 no call pass 10859 EGFR_E00001601336_1 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(1) 17 FFPE CGCAG C/T TCATG CMDL140158 FLD0340 FLD0364 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.431 0.487 1929 1910 pass pass 28102 33388 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140158 FLD0340 FLD0364 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.998 0.988 1993 1917 pass pass 86090 80714 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140158 FLD0340 FLD0364 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.072 607 QD no call 708 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL140158 FLD0340 FLD0364 intron TP53 c.96+23G>A chr17 7579677 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579677", "IGV") medium 0.211 1432 no call pass 5289 EXP0116_TP53_E3 ENSG00000141510 3 of 10 58 FFPE AGGTC C/T CCAGC CMDL140158 FLD0340 FLD0364 intron TP53 c.96+22G>A chr17 7579678 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579678", "IGV") medium 0.272 1432 no call pass 3384 EXP0116_TP53_E3 ENSG00000141510 3 of 10 57 FFPE GGTCC C/T CAGCC CMDL140158 FLD0340 FLD0364 intron TP53 c.96+11G>A chr17 7579689 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579689", "IGV") medium 0.245 607 pass no call 4089 EXP0116_TP53_E3 ENSG00000141510 3 of 10 46 FFPE CAACC C/T TTGTC CMDL140158 FLD0340 FLD0364 intron PTEN c.802-162C>T chr10 89720489 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720489", "IGV") low 0.094 1801 no call QD 565 PTEN_E00001156315_1m ENSG00000171862 7 of 8 9 FFPE ATAGT C/T TTTGT CMDL140158 FLD0340 FLD0364 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") medium 0.048 206 no call pass 1008 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL140158 FLD0340 FLD0364 intron PTEN c.802-12T>C chr10 89720639 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720639", "IGV") low 0.022 206 no call QD 303 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs587781129 benign 46 FFPE TTTTT T/C TTTTT CMDL140158 FLD0340 FLD0364 intron PTEN c.802-10T>C chr10 89720641 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720641", "IGV") low 0.008 102 LowQual,QD no call 24 PTEN_E00001156315_1m ENSG00000171862 7 of 8 44 FFPE TTTTT T/C TTTTT CMDL140158 FLD0340 FLD0364 nonsynonymous PTEN c.364A>G p.I122V Att/Gtt chr10 89692880 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89692880", "IGV") low 0.086 1677 QD no call 444 PTEN_E00001156330_3 ENSG00000171862 5 of 9 tolerated(0.68) benign(0.14) 17 FFPE CAGCA A/G TTCAC CMDL140158 FLD0340 FLD0364 nonsynonymous PTEN c.477G>C p.R159S agG/agC chr10 89692993 G C =hyperlink("http://localhost:60151/goto?locus=chr10:89692993", "IGV") high 0.866 0.942 1629 1592 pass pass 55171 61108 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5287 deleterious(0) probably_damaging(0.998) 32 FFPE GTAAG G/C ACCAG CMDL140158 FLD0340 FLD0364 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.997 1743 no call pass 72843 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL140158 FLD0340 FLD0364 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.132 1444 QD no call 2768 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL140158 FLD0340 FLD0364 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.991 0.989 2892 2717 pass pass 101257 92838 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140158 FLD0340 FLD0364 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") low 0.191 2892 QD no call 4320 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL140158 FLD0340 FLD0364 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.987 0.990 1281 1408 pass pass 41137 44824 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140158 FLD0340 FLD0364 3_prime_UTR TP53 c.*51C>T chr17 7572876 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572876", "IGV") low 0.084 1586 no call QD 802 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs760698953 7 FFPE GGGGA G/A GGAGA CMDL140158 FLD0340 FLD0364 3_prime_UTR TP53 c.*42C>T chr17 7572885 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572885", "IGV") low 0.076 4110 QD no call 559 TP53_E00001757276_1 ENSG00000141510 11 of 11 16 FFPE GAGAT G/A GGGGT CMDL140158 FLD0340 FLD0364 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.142 4110 QD no call 2696 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140158 FLD0340 FLD0364 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.207 4110 pass no call 10664 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140158 FLD0340 FLD0364 nonsynonymous TP53 c.844C>T p.R282W Cgg/Tgg chr17 7577094 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577094", "IGV") high 0.936 0.926 4147 3804 pass pass 128363 115954 TP53_E00001789298_3 25105660, 25404506, 22536362 ENSG00000141510 8 of 11 CM920678, CM056413, rs28934574, TP53_g.13824C>A, TP53_g.13824C>G, TP53_g.13824C>T, TP53_g.13824del, COSM43813, COSM10704, COSM10992, COSM44918, COSM99925, COSM99934, COSM3378339, COSM3675520, COSM1725698, COSM1636702 deleterious(0) probably_damaging(0.997) likely_benign,pathogenic 72 FFPE GCGCC G/A GTCTC CMDL140163 FLD0341 FLD0365 intron EGFR c.2284-10C>T chr7 55248976 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248976", "IGV") medium 0.433 3746 no call pass 24869 EGFR_E00001601336_1 ENSG00000146648 19 of 27 56 FFPE TCTCC C/T TCCCT CMDL140163 FLD0341 FLD0365 splice_region,intron EGFR c.2284-4C>T chr7 55248982 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248982", "IGV") medium 0.469 2961 pass no call 28041 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs766533982 62 FFPE TCCCT C/T CAGGA CMDL140163 FLD0341 FLD0365 synonymous EGFR c.2304C>T c.2304C>T(p.%3D) agC/agT chr7 55249006 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249006", "IGV") medium 0.520 2961 pass no call 33906 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs778199483 86 FFPE GCCAG C/T GTGGA CMDL140163 FLD0341 FLD0365 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") medium 0.434 1980 no call pass 29077 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL140163 FLD0341 FLD0365 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.644 0.465 1596 2025 pass pass 39755 32963 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL140163 FLD0341 FLD0365 intron EGFR c.2469+14G>A chr7 55249185 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249185", "IGV") low 0.088 1493 QD no call 512 EGFR_E00001601336_2 ENSG00000146648 20 of 27 10 FFPE GGAAG G/A GAGAT CMDL140163 FLD0341 FLD0365 synonymous EGFR c.2508C>T c.2508C>T(p.%3D) cgC/cgT chr7 55259450 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259450", "IGV") high 0.491 0.464 3535 4526 pass pass 35634 42528 EGFR_E00001681524_1 17956637, 21264207, 23093229, 22192147, 23211371, 21869887, 16324836 ENSG00000146648 21 of 28 rs2229066, COSM85893 benign T:0.0054 76 FFPE CACCG C/T GACCT CMDL140163 FLD0341 FLD0365 synonymous EGFR c.2508C>T c.2508C>T(p.%3D) cgC/cgT chr7 55259450 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55259450", "IGV") high 0.573 0.541 1656 1909 pass pass 21380 22839 EGFR_E00001681524_2 17956637, 21264207, 23093229, 22192147, 23211371, 21869887, 16324836 ENSG00000146648 21 of 28 rs2229066, COSM85893 benign T:0.0054 34 FFPE CACCG C/T GACCT CMDL140163 FLD0341 FLD0365 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.991 0.997 1673 1740 pass pass 72319 75253 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL140163 FLD0341 FLD0365 nonsynonymous EGFR c.2835G>A p.M945I atG/atA chr7 55266543 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55266543", "IGV") medium 0.134 1720 no call pass 3456 EGFR_E00001779947_1 ENSG00000146648 23 of 28 deleterious(0) probably_damaging(0.999) 9 FFPE TACAT G/A ATCAT CMDL140163 FLD0341 FLD0365 intron TP53 c.97-48G>A chr17 7579638 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579638", "IGV") low 0.124 1368 no call QD 1120 EXP0116_TP53_E3 ENSG00000141510 3 of 10 62 FFPE GCCCC C/T CAGCC CMDL140163 FLD0341 FLD0365 nonsynonymous TP53 c.85A>G p.N29D Aac/Gac chr17 7579711 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7579711", "IGV") medium 0.565 1368 no call pass 25751 EXP0116_TP53_E3 ENSG00000141510 3 of 11 tolerated(0.58) benign(0.013) 24 FFPE GTTGT T/C TTCAG CMDL140163 FLD0341 FLD0365 splice_region,intron TP53 c.75-7C>T chr17 7579728 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579728", "IGV") medium 0.171 216 pass no call 683 EXP0116_TP53_E3 ENSG00000141510 2 of 10 7 FFPE TGAAA G/A ACAAG CMDL140163 FLD0341 FLD0365 splice_donor PIK3CA c.1664+1G>A chr3 178936123 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936123", "IGV") low 0.091 1027 QD no call 205 PIK3CA_Ex10_gap ENSG00000121879 10 of 20 4 FFPE CACAG G/A TAAGT CMDL140163 FLD0341 FLD0365 intron PTEN c.802-36T>C chr10 89720615 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720615", "IGV") low 0.087 72 QD no call 77 PTEN_E00001156315_1m ENSG00000171862 7 of 8 70 FFPE GTCAT T/C TCATT CMDL140163 FLD0341 FLD0365 intron PTEN c.802-11T>C chr10 89720640 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720640", "IGV") medium 0.127 309 no call pass 6108 PTEN_E00001156315_1m ENSG00000171862 7 of 8 45 FFPE TTTTT T/C TTTTT CMDL140163 FLD0341 FLD0365 splice_region,intron PTEN c.802-3T>C chr10 89720648 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720648", "IGV") medium 0.127 309 no call pass 8066 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs587780712, COSM5928 uncertain_significance 37 FFPE TTTTT T/C AGGAC CMDL140163 FLD0341 FLD0365 nonsynonymous PTEN c.691C>T p.P231S Ccc/Tcc chr10 89717666 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717666", "IGV") medium 0.174 4253 no call pass 11481 PTEN_E00001156321_2 ENSG00000171862 7 of 9 tolerated(0.52) benign(0.027) 27 FFPE CAGGA C/T CCACA CMDL140163 FLD0341 FLD0365 nonsynonymous PTEN c.709A>G p.K237E Aag/Gag chr10 89717684 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717684", "IGV") low 0.097 4253 no call QD 3977 PTEN_E00001156321_2 ENSG00000171862 7 of 9 tolerated(0.23) benign(0.038) 45 FFPE AAGAC A/G AGTTC CMDL140163 FLD0341 FLD0365 synonymous PTEN c.723T>C c.723T>C(p.%3D) ttT/ttC chr10 89717698 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89717698", "IGV") low 0.099 4253 no call QD 4219 PTEN_E00001156321_2 ENSG00000171862 7 of 9 rs17849090, COSM5861 59 FFPE TACTT T/C GAGTT CMDL140163 FLD0341 FLD0365 synonymous PTEN c.732T>C c.732T>C(p.%3D) ccT/ccC chr10 89717707 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89717707", "IGV") medium 0.171 4253 no call pass 12158 PTEN_E00001156321_2 ENSG00000171862 7 of 9 COSM327228 68 FFPE TTCCC T/C CAGCC CMDL140163 FLD0341 FLD0365 nonsynonymous PTEN c.749G>A p.C250Y tGt/tAt chr10 89717724 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717724", "IGV") low 0.139 4253 no call QD 37 PTEN_E00001156321_2 ENSG00000171862 7 of 9 tolerated(0.42) benign(0.02) 52 FFPE TGTGT G/A TGGTG CMDL140163 FLD0341 FLD0365 stop_gained PTEN c.781C>T p.Q261* Cag/Tag chr10 89717756 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717756", "IGV") low 0.176 4253 no call QD 4040 PTEN_E00001156321_2 ENSG00000171862 7 of 9 rs730882131, COSM5160 pathogenic 20 FFPE ACAAA C/T AGAAC CMDL140163 FLD0341 FLD0365 intron PTEN c.801+23G>A chr10 89717799 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717799", "IGV") low 0.104 1972 no call QD 2423 PTEN_E00001156321_4m ENSG00000171862 7 of 8 rs116160352 benign A:0.0008 30 FFPE ATTGG G/A AGAAA CMDL140163 FLD0341 FLD0365 intron PTEN c.801+42G>C chr10 89717818 G C =hyperlink("http://localhost:60151/goto?locus=chr10:89717818", "IGV") low 0.148 3037 QD no call 1164 PTEN_E00001156321_4m ENSG00000171862 7 of 8 49 FFPE ATAAG G/C ACAGA CMDL140163 FLD0341 FLD0365 intron PTEN c.801+107C>T chr10 89717883 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717883", "IGV") low 0.103 3914 no call QD 4649 PTEN_E00001156321_4m ENSG00000171862 7 of 8 51 FFPE TAGAT C/T TGCAG CMDL140163 FLD0341 FLD0365 intron PTEN c.801+110C>T chr10 89717886 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717886", "IGV") low 0.103 3914 no call QD 4649 PTEN_E00001156321_4m ENSG00000171862 7 of 8 48 FFPE ATCTG C/T AGGTG CMDL140163 FLD0341 FLD0365 intron PTEN c.801+130G>A chr10 89717906 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717906", "IGV") medium 0.157 1509 pass no call 4685 PTEN_E00001156321_4m ENSG00000171862 7 of 8 28 FFPE CTCTG G/A CATTG CMDL140163 FLD0341 FLD0365 intron PTEN c.801+140G>A chr10 89717916 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717916", "IGV") low 0.086 1942 no call QD 177 PTEN_E00001156321_4m ENSG00000171862 7 of 8 18 FFPE GGTGA G/A ACATT CMDL140163 FLD0341 FLD0365 intron PTEN c.801+143A>G chr10 89717919 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717919", "IGV") low 0.129 1509 QD no call 2883 PTEN_E00001156321_4m ENSG00000171862 7 of 8 15 FFPE GAGAC A/G TTATA CMDL140163 FLD0341 FLD0365 synonymous PTEN c.441G>A c.441G>A(p.%3D) aaG/aaA chr10 89692957 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692957", "IGV") low 0.186 2686 no call QD 3171 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CX992109 68 FFPE TTAAA G/A GCACA CMDL140163 FLD0341 FLD0365 nonsynonymous PTEN c.442G>A p.A148T Gca/Aca chr10 89692958 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692958", "IGV") low 0.158 2686 no call QD 1853 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM5071, COSM1561206 tolerated(0.06) benign(0.394) 67 FFPE TAAAG G/A CACAA CMDL140163 FLD0341 FLD0365 intron PTEN c.80-14A>G chr10 89653768 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89653768", "IGV") low 0.119 1661 QD no call 2737 PTEN_E00001156351_1 ENSG00000171862 1 of 8 rs768354874 1 FFPE CCTTA A/G CTAAA CMDL140163 FLD0341 FLD0365 splice_region,intron PTEN c.80-8G>A chr10 89653774 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89653774", "IGV") medium 0.130 2226 no call pass 5068 PTEN_E00001156351_1 ENSG00000171862 1 of 8 7 FFPE CTAAA G/A TACTC CMDL140163 FLD0341 FLD0365 synonymous PTEN c.159A>C c.159A>C(p.%3D) gtA/gtC chr10 89653861 A C =hyperlink("http://localhost:60151/goto?locus=chr10:89653861", "IGV") low 0.133 4456 no call QD 135 PTEN_E00001156351_1 ENSG00000171862 2 of 9 rs189583426, COSM1349481 likely_benign G:0.0002 36 FFPE GATGT A/C GTAAG CMDL140163 FLD0341 FLD0365 intron PTEN c.79+45C>T chr10 89624350 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89624350", "IGV") low 0.087 1779 no call QD 538 PTEN_E00001456562_1 ENSG00000171862 1 of 8 3 FFPE ACTCT C/T TTAGA CMDL140163 FLD0341 FLD0365 intron TP53 c.74+49C>T chr17 7579790 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579790", "IGV") medium 0.230 1642 no call pass 8161 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs762400295 13 FFPE GGGCT G/A GGGTT CMDL140163 FLD0341 FLD0365 intron TP53 c.74+42C>T chr17 7579797 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579797", "IGV") low 0.164 678 QD no call 336 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs767153311 20 FFPE GGTTG G/A GGTGG CMDL140163 FLD0341 FLD0365 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.988 0.994 678 3234 pass pass 25211 123607 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL140163 FLD0341 FLD0365 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") low 0.128 3234 no call QD 423 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL140163 FLD0341 FLD0365 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") low 0.176 3234 no call QD 3253 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL140163 FLD0341 FLD0365 nonsynonymous TP53 c.53C>T p.T18I aCa/aTa chr17 7579860 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579860", "IGV") low 0.150 678 QD no call 330 TP53_E00001596491_1 ENSG00000141510 2 of 11 deleterious(0) probably_damaging(0.988) 63 FFPE AAAAT G/A TTTCC CMDL140163 FLD0341 FLD0365 nonsynonymous TP53 c.274C>T p.P92S Ccc/Tcc chr17 7579413 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579413", "IGV") low 0.135 625 QD no call 209 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11505del, TP53_g.11505C>G, TP53_g.11505C>T, COSM45844, COSM45290 deleterious(0.02) benign(0.398) 36 FFPE CAGGG G/A CCAGG CMDL140163 FLD0341 FLD0365 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.997 0.991 625 858 pass pass 23655 32054 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL140163 FLD0341 FLD0365 3_prime_UTR TP53 c.*50C>T chr17 7572877 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572877", "IGV") medium 0.098 0.348 1398 1923 QD pass 1176 18460 TP53_E00001757276_1 ENSG00000141510 11 of 11 8 FFPE GGGAG G/A GAGAG CMDL140163 FLD0341 FLD0365 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") medium 0.129 0.550 2849 3993 QD pass 640 64487 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL140163 FLD0341 FLD0365 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.344 3993 no call pass 37060 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL140163 FLD0341 FLD0365 3_prime_UTR TP53 c.*36C>T chr17 7572891 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572891", "IGV") medium 0.259 2849 pass no call 10841 TP53_E00001757276_1 ENSG00000141510 11 of 11 22 FFPE GGGGT G/A GGAGG CMDL140163 FLD0341 FLD0365 3_prime_UTR TP53 c.*32C>T chr17 7572895 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572895", "IGV") medium 0.203 3993 no call pass 11507 TP53_E00001757276_1 ENSG00000141510 11 of 11 26 FFPE TGGGA G/A GCTGT CMDL140163 FLD0341 FLD0365 3_prime_UTR TP53 c.*31C>T chr17 7572896 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572896", "IGV") medium 0.204 3993 no call pass 12104 TP53_E00001757276_1 ENSG00000141510 11 of 11 27 FFPE GGGAG G/A CTGTC CMDL140163 FLD0341 FLD0365 3_prime_UTR TP53 c.*21C>T chr17 7572906 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572906", "IGV") medium 0.237 3993 no call pass 27161 TP53_E00001757276_1 ENSG00000141510 11 of 11 37 FFPE CAGTG G/A GGAAC CMDL140163 FLD0341 FLD0365 3_prime_UTR TP53 c.*7C>T chr17 7572920 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572920", "IGV") medium 0.207 3993 no call pass 11644 TP53_E00001757276_1 ENSG00000141510 11 of 11 51 FFPE AAGTG G/A AGAAT CMDL140163 FLD0341 FLD0365 nonsynonymous TP53 c.925C>T p.P309S Ccc/Tcc chr17 7576921 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576921", "IGV") low 0.077 5244 no call QD 715 TP53_E00001789298_1 ENSG00000141510 9 of 11 CM055562, TP53_g.13997C>T, COSM11677, COSM1679488, COSM1679489 tolerated(0.16) benign(0.088) 43 FFPE GTTGG G/A CAGTG CMDL140163 FLD0341 FLD0365 splice_region,intron TP53 c.920-5C>T chr17 7576931 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7576931", "IGV") low 0.078 5244 no call QD 712 TP53_E00001789298_1 ENSG00000141510 8 of 10 rs34361146 uncertain_significance A:0.0002 33 FFPE GCTAG G/A AAAGA CMDL140163 FLD0341 FLD0365 stop_gained TP53 c.916C>T p.R306* Cga/Tga chr17 7577022 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577022", "IGV") high 0.515 0.635 3378 4426 pass pass 36449 66219 TP53_E00001789298_2 ENSG00000141510 8 of 11 CM971506, rs121913344, TP53_g.13896del, TP53_g.13896C>T, COSM10663, COSM44631, COSM99947, COSM3388168, COSM1640820 pathogenic 34 FFPE ACCTC G/A CTTAG CMDL150005 FLD0342 FLD0366 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.515 0.536 2073 2214 pass pass 38124 42241 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150005 FLD0342 FLD0366 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.543 0.481 1849 2011 pass pass 37994 33347 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150005 FLD0342 FLD0366 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.994 0.995 1868 2201 pass pass 79728 93845 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150005 FLD0342 FLD0366 nonsynonymous PIK3CA c.3140A>G p.H1047R cAt/cGt chr3 178952085 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178952085", "IGV") high 0.331 0.336 3970 4637 pass pass 17694 21032 PIK3CA_Exn21_gap 25710561 ENSG00000121879 21 of 21 rs121913279, COSM776, COSM775, COSM249874, COSM94987, COSM94986 tolerated(0.11) possibly_damaging(0.529) pathogenic 28 FFPE TGCAC A/G TCATG CMDL150005 FLD0342 FLD0366 nonsynonymous TP53 c.524G>A p.R175H cGc/cAc chr17 7578406 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578406", "IGV") high 0.332 0.335 4545 4998 pass pass 22652 23432 TP53_E00001255919_5 25105660, 21264207, 24929325, 25404506 ENSG00000141510 5 of 11 CM951224, rs28934578, CM062017, TP53_g.12512G>T, TP53_g.12512G>C, TP53_g.12512G>A, COSM10718, COSM10648, COSM45416, COSM99914, COSM1679508, COSM99022, COSM1679510, COSM99023, COSM1679512, COSM3355994, COSM1640851, COSM1679509, COSM99024, COSM1679511 tolerated(0.11) benign(0.308) pathogenic 28 FFPE GGCAG C/T GCCTC CMDL150005 FLD0342 FLD0366 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.988 0.995 2414 3040 pass pass 84298 104445 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150005 FLD0342 FLD0366 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.992 0.992 1803 1940 pass pass 57921 62879 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150005 FLD0342 FLD0366 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.136 3819 no call QD 249 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150006 FLD0343 FLD0367 nonsynonymous EGFR c.2315C>T p.P772L cCc/cTc chr7 55249017 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249017", "IGV") medium 0.188 0.420 4231 4594 QD pass 5230 32125 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM115794 deleterious(0) probably_damaging(0.986) 76 FFPE CAACC C/T CCACG CMDL150006 FLD0343 FLD0367 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.981 0.984 2051 2235 pass pass 86311 93099 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150006 FLD0343 FLD0367 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.997 0.994 2050 2234 pass pass 97368 98333 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150006 FLD0343 FLD0367 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.975 0.986 1950 2308 pass pass 80620 97587 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150006 FLD0343 FLD0367 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") high 0.940 0.985 704 783 pass pass 19355 24708 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL150006 FLD0343 FLD0367 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.024 213 no call QD 128 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150006 FLD0343 FLD0367 nonsynonymous PTEN c.389G>A p.R130Q cGa/cAa chr10 89692905 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692905", "IGV") high 0.640 0.637 3507 3921 pass pass 51993 58992 PTEN_E00001156330_3 ENSG00000171862 5 of 9 CM991081, rs121909229, rs121913292, CM981670, COSM5817, COSM5033, COSM5277, COSM5216 deleterious(0.02) probably_damaging(0.989) likely_pathogenic,pathogenic,pathogenic 42 FFPE GGGAC G/A AACTG CMDL150006 FLD0343 FLD0367 stop_gained PTEN c.118G>T p.E40* Gaa/Taa chr10 89653820 G T =hyperlink("http://localhost:60151/goto?locus=chr10:89653820", "IGV") medium 0.352 5148 no call pass 27819 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM5328 53 FFPE CTGCA G/T AAAGA CMDL150006 FLD0343 FLD0367 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.095 1169 no call QD 733 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150006 FLD0343 FLD0367 intron TP53 c.74+36C>T chr17 7579803 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579803", "IGV") low 0.185 1823 QD no call 900 TP53_E00001596491_1 ENSG00000141510 2 of 10 26 FFPE GGTGG G/A GGTGG CMDL150006 FLD0343 FLD0367 intron TP53 c.74+28C>T chr17 7579811 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579811", "IGV") low 0.133 2320 no call QD 2609 TP53_E00001596491_1 ENSG00000141510 2 of 10 34 FFPE TGGTG G/A GCCTG CMDL150006 FLD0343 FLD0367 synonymous TP53 c.276C>T c.276C>T(p.%3D) ccC/ccT chr17 7579411 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579411", "IGV") low 0.071 659 no call QD 55 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11507C>T 34 FFPE GACAG G/A GGCCA CMDL150006 FLD0343 FLD0367 nonsynonymous TP53 c.221C>T p.A74V gCc/gTc chr17 7579466 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579466", "IGV") low 0.133 659 no call QD 694 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs587781832, TP53_g.11452C>T, COSM43671 tolerated(0.4) benign(0.003) uncertain_significance 35 FFPE CAGGG G/A CCACG CMDL150006 FLD0343 FLD0367 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.148 3654 QD no call 1365 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150006 FLD0343 FLD0367 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") medium 0.233 3529 no call pass 14112 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL150007 FLD0344 FLD0368 intron EGFR c.2284-45G>A chr7 55248941 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55248941", "IGV") medium 0.143 1691 no call pass 6557 EGFR_E00001601336_1 ENSG00000146648 19 of 27 21 FFPE CTTCT G/A GCCAC CMDL150007 FLD0344 FLD0368 intron EGFR c.2284-10C>T chr7 55248976 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248976", "IGV") low 0.181 4238 QD no call 3483 EGFR_E00001601336_1 ENSG00000146648 19 of 27 56 FFPE TCTCC C/T TCCCT CMDL150007 FLD0344 FLD0368 nonsynonymous EGFR c.2288C>T p.A763V gCc/gTc chr7 55248990 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248990", "IGV") low 0.176 3612 no call QD 2073 EGFR_E00001601336_1 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(1) 70 FFPE GGAAG C/T CTACG CMDL150007 FLD0344 FLD0368 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.601 0.541 2297 1921 pass pass 50216 37214 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150007 FLD0344 FLD0368 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.537 0.425 2182 2042 pass pass 44382 29126 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150007 FLD0344 FLD0368 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.999 0.998 2106 2208 pass pass 91100 95276 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150007 FLD0344 FLD0368 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.503 0.453 5297 5017 pass pass 54850 44333 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150007 FLD0344 FLD0368 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") high 0.997 0.998 599 1080 pass pass 20975 44344 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL150007 FLD0344 FLD0368 intron TP53 c.97-38G>A chr17 7579628 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579628", "IGV") medium 0.252 599 pass no call 3034 EXP0116_TP53_E3 ENSG00000141510 3 of 10 52 FFPE CAGGT C/T CTCAG CMDL150007 FLD0344 FLD0368 intron TP53 c.97-44G>A chr17 7579634 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579634", "IGV") medium 0.321 1080 no call pass 6503 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs762445877 58 FFPE CTCAG C/T CCCCC CMDL150007 FLD0344 FLD0368 splice_region,intron TP53 c.96+6G>A chr17 7579694 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579694", "IGV") medium 0.331 1080 no call pass 12941 EXP0116_TP53_E3 ENSG00000141510 3 of 10 41 FFPE CTTGT C/T CTTAC CMDL150007 FLD0344 FLD0368 splice_acceptor PIK3CA c.1540-1G>A chr3 178935997 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178935997", "IGV") low 0.083 925 QD no call 370 PIK3CA_Ex10_gap ENSG00000121879 9 of 20 COSM1726693, COSM1726692 33 FFPE TTACA G/A AGTAA CMDL150007 FLD0344 FLD0368 intron PTEN c.801+130G>A chr10 89717906 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717906", "IGV") low 0.115 1913 no call QD 2766 PTEN_E00001156321_4m ENSG00000171862 7 of 8 28 FFPE CTCTG G/A CATTG CMDL150007 FLD0344 FLD0368 intron PTEN c.801+131C>T chr10 89717907 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89717907", "IGV") low 0.121 1987 QD no call 2511 PTEN_E00001156321_4m ENSG00000171862 7 of 8 27 FFPE TCTGG C/T ATTGG CMDL150007 FLD0344 FLD0368 nonsynonymous PTEN c.428G>A p.G143D gGc/gAc chr10 89692944 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89692944", "IGV") low 0.147 3761 QD no call 5420 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM28894 tolerated(0.22) benign(0.072) 81 FFPE TCGGG G/A CAAAT CMDL150007 FLD0344 FLD0368 nonsynonymous PTEN c.133G>A p.V45I Gta/Ata chr10 89653835 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89653835", "IGV") low 0.179 4558 QD no call 2822 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM1349477, COSM249824, COSM921065 tolerated(0.2) benign(0.009) 62 FFPE AAGGC G/A TATAC CMDL150007 FLD0344 FLD0368 intron TP53 c.74+56C>T chr17 7579783 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579783", "IGV") low 0.082 716 QD no call 252 TP53_E00001596491_1 ENSG00000141510 2 of 10 6 FFPE TGCTA G/A GGGGC CMDL150007 FLD0344 FLD0368 synonymous TP53 c.291C>T c.291C>T(p.%3D) gtC/gtT chr17 7579396 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579396", "IGV") low 0.094 373 QD no call 345 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11522C>T, COSM473435, COSM473436, COSM473437 19 FFPE GAAGG G/A ACAGA CMDL150007 FLD0344 FLD0368 synonymous TP53 c.276C>T c.276C>T(p.%3D) ccC/ccT chr17 7579411 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579411", "IGV") low 0.102 373 QD no call 443 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11507C>T 34 FFPE GACAG G/A GGCCA CMDL150007 FLD0344 FLD0368 nonsynonymous TP53 c.266C>T p.P89L cCc/cTc chr17 7579421 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579421", "IGV") low 0.121 323 no call LowQual,QD 24 TP53_E00001612188_2 ENSG00000141510 4 of 11 rs730881994, TP53_g.11497C>T, COSM44677 tolerated(0.1) benign(0.007) uncertain_significance 44 FFPE AGGAG G/A GGGCT CMDL150007 FLD0344 FLD0368 nonsynonymous TP53 c.259C>T p.P87S Cca/Tca chr17 7579428 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579428", "IGV") low 0.091 373 QD no call 219 TP53_E00001612188_2 ENSG00000141510 4 of 11 tolerated(0.36) possibly_damaging(0.45) 51 FFPE GGCTG G/A TGCAG CMDL150007 FLD0344 FLD0368 nonsynonymous TP53 c.254C>T p.P85L cCt/cTt chr17 7579433 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579433", "IGV") low 0.112 373 QD no call 148 TP53_E00001612188_2 ENSG00000141510 4 of 11 TP53_g.11485C>T, COSM1386905, COSM45837, COSM1386906, COSM1386907 tolerated(0.42) benign(0.011) 56 FFPE GTGCA G/A GGGCC CMDL150007 FLD0344 FLD0368 3_prime_UTR TP53 c.*51C>T chr17 7572876 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572876", "IGV") medium 0.172 1857 pass no call 7553 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs760698953 7 FFPE GGGGA G/A GGAGA CMDL150007 FLD0344 FLD0368 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.160 3769 QD no call 2602 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150007 FLD0344 FLD0368 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.162 3769 QD no call 5317 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150007 FLD0344 FLD0368 3_prime_UTR TP53 c.*36C>T chr17 7572891 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572891", "IGV") low 0.141 3369 no call QD 1830 TP53_E00001757276_1 ENSG00000141510 11 of 11 22 FFPE GGGGT G/A GGAGG CMDL150007 FLD0344 FLD0368 3_prime_UTR TP53 c.*34C>T chr17 7572893 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572893", "IGV") medium 0.215 3769 pass no call 9969 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs545818827 A:0.0002 24 FFPE GGTGG G/A AGGCT CMDL150007 FLD0344 FLD0368 3_prime_UTR TP53 c.*24C>T chr17 7572903 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572903", "IGV") medium 0.208 3769 pass no call 8645 TP53_E00001757276_1 ENSG00000141510 11 of 11 34 FFPE TGTCA G/A TGGGG CMDL150071 FLD0345 FLD0369 intron EGFR c.2284-56C>T chr7 55248930 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248930", "IGV") low 0.077 2010 QD no call 429 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs41323247 T:0.0038 10 FFPE ATGTG C/T CCCTC CMDL150071 FLD0345 FLD0369 intron EGFR c.2284-34G>A chr7 55248952 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55248952", "IGV") medium 0.190 1895 no call pass 8311 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs202058122 32 FFPE CATGC G/A AAGCC CMDL150071 FLD0345 FLD0369 intron EGFR c.2284-26A>G chr7 55248960 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55248960", "IGV") low 0.136 1914 no call QD 3439 EGFR_E00001601336_1 ENSG00000146648 19 of 27 40 FFPE GCCAC A/G CTGAC CMDL150071 FLD0345 FLD0369 splice_region,intron EGFR c.2284-3C>A chr7 55248983 C A =hyperlink("http://localhost:60151/goto?locus=chr7:55248983", "IGV") low 0.076 4018 QD no call 795 EGFR_E00001601336_1 ENSG00000146648 19 of 27 63 FFPE CCCTC C/A AGGAA CMDL150071 FLD0345 FLD0369 synonymous EGFR c.2304C>T c.2304C>T(p.%3D) agC/agT chr7 55249006 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249006", "IGV") low 0.077 4018 QD no call 795 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs778199483 86 FFPE GCCAG C/T GTGGA CMDL150071 FLD0345 FLD0369 synonymous EGFR c.2316C>T c.2316C>T(p.%3D) ccC/ccT chr7 55249018 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249018", "IGV") low 0.149 3704 no call QD 75 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs761020556, COSM13434, COSM12388 75 FFPE AACCC C/T CACGT CMDL150071 FLD0345 FLD0369 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.885 0.983 2008 1809 pass pass 70303 75886 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150071 FLD0345 FLD0369 synonymous EGFR c.2370G>A c.2370G>A(p.%3D) acG/acA chr7 55249072 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249072", "IGV") medium 0.148 1809 no call pass 4060 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs376452156 21 FFPE ATCAC G/A CAGCT CMDL150071 FLD0345 FLD0369 nonsynonymous EGFR c.2381C>T p.P794L cCc/cTc chr7 55249083 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249083", "IGV") low 0.074 2008 QD no call 65 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM244213 deleterious(0) probably_damaging(1) 10 FFPE CATGC C/T CTTCG CMDL150071 FLD0345 FLD0369 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.994 0.988 2026 1803 pass pass 95981 88077 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150071 FLD0345 FLD0369 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.468 0.500 2180 1939 pass pass 36243 34692 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150071 FLD0345 FLD0369 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") medium 0.106 1500 pass no call 3836 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL150071 FLD0345 FLD0369 intron TP53 c.96+24G>A chr17 7579676 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579676", "IGV") medium 0.282 1122 no call pass 3778 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE CAGGT C/T CCCAG CMDL150071 FLD0345 FLD0369 intron TP53 c.96+22G>A chr17 7579678 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579678", "IGV") medium 0.189 1122 no call pass 3843 EXP0116_TP53_E3 ENSG00000141510 3 of 10 57 FFPE GGTCC C/T CAGCC CMDL150071 FLD0345 FLD0369 intron TP53 c.96+21G>A chr17 7579679 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579679", "IGV") low 0.150 1500 QD no call 1308 EXP0116_TP53_E3 ENSG00000141510 3 of 10 56 FFPE GTCCC C/T AGCCC CMDL150071 FLD0345 FLD0369 intron TP53 c.96+17G>A chr17 7579683 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579683", "IGV") low 0.090 1500 QD no call 1894 EXP0116_TP53_E3 ENSG00000141510 3 of 10 52 FFPE CCAGC C/T CAACC CMDL150071 FLD0345 FLD0369 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.014 113 LowQual,QD no call 14 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150071 FLD0345 FLD0369 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.004 1271 QD no call 392 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL150071 FLD0345 FLD0369 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.998 1271 QD no call 392 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150071 FLD0345 FLD0369 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") medium 0.157 0.078 1411 1298 pass QD 5058 282 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL150071 FLD0345 FLD0369 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.455 0.704 2773 2614 pass pass 31606 55843 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150071 FLD0345 FLD0369 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.798 0.715 1247 1226 pass pass 27499 21196 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150071 FLD0345 FLD0369 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.121 3855 no call LowQual,QD 22 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150071 FLD0345 FLD0369 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.133 4102 QD no call 263 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150071 FLD0345 FLD0369 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") low 0.119 0.135 4102 3855 QD QD 1964 1822 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL150071 FLD0345 FLD0369 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") low 0.116 4102 QD no call 2640 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL150077 FLD0346 FLD0370 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.486 0.542 1849 1982 pass pass 31545 38692 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150077 FLD0346 FLD0370 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.490 0.515 1657 1712 pass pass 28033 31644 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150077 FLD0346 FLD0370 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.991 0.991 1761 1804 pass pass 75034 76133 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150077 FLD0346 FLD0370 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.514 0.481 3808 4215 pass pass 38835 37009 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150077 FLD0346 FLD0370 intron TP53 c.96+24G>A chr17 7579676 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579676", "IGV") low 0.132 1083 QD no call 1210 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE CAGGT C/T CCCAG CMDL150077 FLD0346 FLD0370 nonsynonymous KRAS c.70A>T p.I24F Att/Ttt chr12 25398249 T A =hyperlink("http://localhost:60151/goto?locus=chr12:25398249", "IGV") high 0.452 0.469 4295 4169 pass pass 35318 37152 KRAS_AA_HS ENSG00000133703 2 of 6 COSM1360865, COSM1360864 deleterious(0) possibly_damaging(0.543) 61 FFPE CTGAA T/A TAGCT CMDL150077 FLD0346 FLD0370 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.536 1433 pass no call 26613 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150077 FLD0346 FLD0370 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.575 0.530 2297 2547 pass pass 32309 29725 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150077 FLD0346 FLD0370 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.806 0.803 1503 1616 pass pass 33577 36336 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150087 FLD0347 FLD0371 nonsynonymous EGFR c.2317C>T p.H773Y Cac/Tac chr7 55249019 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249019", "IGV") low 0.119 4409 no call QD 2213 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs767075090 tolerated(0.54) benign(0.102) 74 FFPE ACCCC C/T ACGTG CMDL150087 FLD0347 FLD0371 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.432 0.481 1972 2078 pass pass 29589 35675 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150087 FLD0347 FLD0371 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.408 0.495 1990 1996 pass pass 25852 36415 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150087 FLD0347 FLD0371 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.985 0.994 1999 2188 pass pass 84431 93151 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150087 FLD0347 FLD0371 intron TP53 c.97-32G>A chr17 7579622 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579622", "IGV") medium 0.121 1415 pass no call 4146 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs754228616 46 FFPE GAGGA C/T CAGGT CMDL150087 FLD0347 FLD0371 intron TP53 c.97-41G>A chr17 7579631 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579631", "IGV") medium 0.116 0.127 1415 1447 pass QD 4131 394 EXP0116_TP53_E3 ENSG00000141510 3 of 10 55 FFPE GTCCT C/T AGCCC CMDL150087 FLD0347 FLD0371 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") high 0.134 0.155 1415 1447 pass pass 4423 5376 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL150087 FLD0347 FLD0371 intron TP53 c.97-48G>A chr17 7579638 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579638", "IGV") medium 0.138 1415 pass no call 4613 EXP0116_TP53_E3 ENSG00000141510 3 of 10 62 FFPE GCCCC C/T CAGCC CMDL150087 FLD0347 FLD0371 intron TP53 c.97-54G>A chr17 7579644 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579644", "IGV") medium 0.540 1415 pass no call 4622 EXP0116_TP53_E3 ENSG00000141510 3 of 10 68 FFPE CAGCC C/T CCCAG CMDL150087 FLD0347 FLD0371 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.108 1502 no call QD 2000 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150087 FLD0347 FLD0371 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.511 0.500 2940 3011 pass pass 32537 32708 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150087 FLD0347 FLD0371 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.769 0.780 1514 1718 pass pass 28898 34044 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150087 FLD0347 FLD0371 nonsynonymous TP53 c.842A>T p.D281V gAc/gTc chr17 7577096 T A =hyperlink("http://localhost:60151/goto?locus=chr17:7577096", "IGV") low 0.199 0.186 3865 3973 QD QD 5358 2626 TP53_E00001789298_3 ENSG00000141510 8 of 11 rs587781525, CM004343, CM056068, CM114008, TP53_g.13822A>G, TP53_g.13822del, TP53_g.13822A>C, TP53_g.13822A>T, COSM11232, COSM45729, COSM11665, COSM1559473, COSM1640824, COSM562341, COSM1649342, COSM1640825 deleterious(0) probably_damaging(0.99) pathogenic 71 FFPE GCCGG T/A CTCTC CMDL150097 FLD0348 FLD0372 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.989 0.986 2199 2085 pass pass 93655 88983 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150097 FLD0348 FLD0372 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.992 0.995 1940 1801 pass pass 91648 86135 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150097 FLD0348 FLD0372 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.994 0.995 2072 1739 pass pass 88290 74681 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150097 FLD0348 FLD0372 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") medium 0.258 1426 no call pass 10771 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL150097 FLD0348 FLD0372 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") medium 0.219 1426 no call pass 10641 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL150097 FLD0348 FLD0372 intron TP53 c.96+22G>A chr17 7579678 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579678", "IGV") medium 0.248 1614 pass no call 4057 EXP0116_TP53_E3 ENSG00000141510 3 of 10 57 FFPE GGTCC C/T CAGCC CMDL150097 FLD0348 FLD0372 splice_region,intron TP53 c.96+6G>A chr17 7579694 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579694", "IGV") low 0.125 1614 QD no call 404 EXP0116_TP53_E3 ENSG00000141510 3 of 10 41 FFPE CTTGT C/T CTTAC CMDL150097 FLD0348 FLD0372 nonsynonymous KRAS c.35G>T p.G12V gGt/gTt chr12 25398284 C A =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") high 0.561 0.576 4576 4512 pass pass 56785 54782 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) possibly_damaging(0.479) 26 FFPE CGCCA C/A CAGCT CMDL150097 FLD0348 FLD0372 synonymous TP53 c.639A>G c.639A>G(p.%3D) cgA/cgG chr17 7578210 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578210", "IGV") high 0.726 0.774 3343 3228 pass pass 61088 65217 TP53_E00001255919_1 20455025, 18798306, 15450681, 23543587, 24218030, 22829934, 18594532, 21869887, 17133269 ENSG00000141510 6 of 11 CX984230, rs1800372, TP53_g.12708A>T, COSM249885, COSM1741221, COSM1741223, COSM1741225, COSM3755916, COSM1741222, COSM1741224 benign C:0.0054 43 FFPE CTATG T/C CGAAA CMDL150097 FLD0348 FLD0372 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.993 0.995 2939 2913 pass pass 107622 102806 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150097 FLD0348 FLD0372 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") low 0.117 2939 QD no call 616 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL150097 FLD0348 FLD0372 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.989 0.996 2003 1872 pass pass 64675 60984 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150106 FLD0349 FLD0373 nonsynonymous BRAF c.1799T>A p.V600E gTg/gAg chr7 140453136 A T =hyperlink("http://localhost:60151/goto?locus=chr7:140453136", "IGV") high 0.472 0.428 5284 4951 pass pass 46240 37275 BRAF_AA_HS ENSG00000157764 15 of 18 CM112509, COSM476, COSM6137, COSM18443 deleterious(0) probably_damaging(0.967) 10 FFPE ATTTC A/T CTGTA CMDL150106 FLD0349 FLD0373 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.986 0.969 1962 1960 pass pass 82591 81453 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150106 FLD0349 FLD0373 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.503 0.544 4528 4372 pass pass 48422 48252 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150106 FLD0349 FLD0373 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") low 0.179 1360 QD no call 2265 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL150106 FLD0349 FLD0373 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.170 1360 QD no call 1691 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL150106 FLD0349 FLD0373 intron PTEN c.802-9T>C chr10 89720642 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720642", "IGV") low 0.012 107 LowQual,QD no call 14 PTEN_E00001156315_1m ENSG00000171862 7 of 8 43 FFPE TTTTT T/C TTTTT CMDL150106 FLD0349 FLD0373 splice_region,intron PTEN c.802-8T>C chr10 89720643 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720643", "IGV") low 0.017 102 no call LowQual,QD 15 PTEN_E00001156315_1m ENSG00000171862 7 of 8 42 FFPE TTTTT T/C TTTTT CMDL150106 FLD0349 FLD0373 intron TP53 c.74+42C>T chr17 7579797 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579797", "IGV") medium 0.213 2269 no call pass 5206 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs767153311 20 FFPE GGTTG G/A GGTGG CMDL150106 FLD0349 FLD0373 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.993 0.996 2653 2269 pass pass 99602 80822 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150106 FLD0349 FLD0373 intron TP53 c.74+36C>T chr17 7579803 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579803", "IGV") low 0.153 2269 no call QD 2142 TP53_E00001596491_1 ENSG00000141510 2 of 10 26 FFPE GGTGG G/A GGTGG CMDL150106 FLD0349 FLD0373 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") medium 0.285 2653 pass no call 10291 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL150106 FLD0349 FLD0373 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.992 0.992 1256 1388 pass pass 38791 43841 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150106 FLD0349 FLD0373 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.218 3878 QD no call 7434 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150106 FLD0349 FLD0373 3_prime_UTR TP53 c.*34C>T chr17 7572893 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572893", "IGV") low 0.131 3298 no call QD 1284 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs545818827 A:0.0002 24 FFPE GGTGG G/A AGGCT CMDL150106 FLD0349 FLD0373 nonsynonymous TP53 c.818G>A p.R273H cGt/cAt chr17 7577120 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7577120", "IGV") high 0.811 0.866 3904 2995 pass pass 81327 69827 TP53_E00001789298_3 25105660 ENSG00000141510 8 of 11 CM920677, CM010472, rs28934576, CM004342, TP53_g.13798G>C, TP53_g.13798del, TP53_g.13798G>A, TP53_g.13798G>T, COSM10660, COSM43896, COSM44440, COSM10779, COSM318169, COSM99729, COSM165077, COSM3356963, COSM3675521, COSM1640828, COSM1645335, COSM1646808 tolerated(0.13) possibly_damaging(0.631) pathogenic T:0.0002 47 FFPE AAACA C/T GCACC CMDL150109 FLD0350 FLD0374 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.993 0.988 2115 2139 pass pass 89960 90784 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150109 FLD0350 FLD0374 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.995 0.988 1841 1832 pass pass 85513 83971 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150109 FLD0350 FLD0374 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.996 0.996 2066 1890 pass pass 87815 80506 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150109 FLD0350 FLD0374 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") high 0.897 0.890 1720 1688 pass pass 42684 45023 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL150109 FLD0350 FLD0374 splice_region,intron TP53 c.75-3C>T chr17 7579724 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579724", "IGV") low 0.101 972 no call QD 443 EXP0116_TP53_E3 ENSG00000141510 2 of 10 11 FFPE AGTCT G/A AAAGA CMDL150109 FLD0350 FLD0374 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.020 134 no call QD 187 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150109 FLD0350 FLD0374 intron PTEN c.802-9T>C chr10 89720642 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720642", "IGV") low 0.008 134 no call QD 44 PTEN_E00001156315_1m ENSG00000171862 7 of 8 43 FFPE TTTTT T/C TTTTT CMDL150109 FLD0350 FLD0374 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") medium 0.135 1379 pass no call 2831 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL150109 FLD0350 FLD0374 intron TP53 c.74+52C>T chr17 7579787 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579787", "IGV") low 0.082 1383 QD no call 154 TP53_E00001596491_1 ENSG00000141510 2 of 10 10 FFPE AGGGG G/A CTGGG CMDL150109 FLD0350 FLD0374 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") low 0.134 2723 QD no call 1006 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150109 FLD0350 FLD0374 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.381 0.445 1027 1165 pass pass 7274 9453 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150109 FLD0350 FLD0374 nonsynonymous TP53 c.844C>T p.R282W Cgg/Tgg chr17 7577094 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577094", "IGV") high 0.771 0.786 3526 3714 pass pass 69726 78951 TP53_E00001789298_3 25105660, 25404506, 22536362 ENSG00000141510 8 of 11 CM920678, CM056413, rs28934574, TP53_g.13824C>A, TP53_g.13824C>G, TP53_g.13824C>T, TP53_g.13824del, COSM43813, COSM10704, COSM10992, COSM44918, COSM99925, COSM99934, COSM3378339, COSM3675520, COSM1725698, COSM1636702 deleterious(0) probably_damaging(0.997) likely_benign,pathogenic 72 FFPE GCGCC G/A GTCTC CMDL150129 FLD0351 FLD0375 intron EGFR c.2284-50C>T chr7 55248936 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248936", "IGV") medium 0.173 1886 no call pass 7677 EGFR_E00001601336_1 ENSG00000146648 19 of 27 16 FFPE CCCTC C/T TTCTG CMDL150129 FLD0351 FLD0375 intron EGFR c.2284-47C>T chr7 55248939 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248939", "IGV") medium 0.213 1886 no call pass 12342 EGFR_E00001601336_1 ENSG00000146648 19 of 27 19 FFPE TCCTT C/T TGGCC CMDL150129 FLD0351 FLD0375 intron EGFR c.2284-42C>T chr7 55248944 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248944", "IGV") medium 0.217 2005 pass no call 11392 EGFR_E00001601336_1 ENSG00000146648 19 of 27 24 FFPE CTGGC C/T ACCAT CMDL150129 FLD0351 FLD0375 intron EGFR c.2284-39C>T chr7 55248947 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248947", "IGV") medium 0.193 1886 no call pass 9334 EGFR_E00001601336_1 ENSG00000146648 19 of 27 27 FFPE GCCAC C/T ATGCG CMDL150129 FLD0351 FLD0375 intron EGFR c.2284-34G>A chr7 55248952 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55248952", "IGV") low 0.114 1886 no call QD 2627 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs202058122 32 FFPE CATGC G/A AAGCC CMDL150129 FLD0351 FLD0375 intron EGFR c.2284-30C>T chr7 55248956 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248956", "IGV") high 0.230 0.213 2032 1893 pass pass 14570 12292 EGFR_E00001601336_1 ENSG00000146648 19 of 27 36 FFPE CGAAG C/T CACAC CMDL150129 FLD0351 FLD0375 intron EGFR c.2284-11C>T chr7 55248975 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248975", "IGV") medium 0.229 3944 pass no call 9603 EGFR_E00001601336_1 ENSG00000146648 19 of 27 55 FFPE CTCTC C/T CTCCC CMDL150129 FLD0351 FLD0375 synonymous EGFR c.2304C>T c.2304C>T(p.%3D) agC/agT chr7 55249006 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249006", "IGV") low 0.184 3944 QD no call 4860 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs778199483 86 FFPE GCCAG C/T GTGGA CMDL150129 FLD0351 FLD0375 synonymous EGFR c.2310C>T c.2310C>T(p.%3D) gaC/gaT chr7 55249012 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249012", "IGV") medium 0.146 3944 pass no call 12547 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs397517110 likely_benign 81 FFPE GTGGA C/T AACCC CMDL150129 FLD0351 FLD0375 nonsynonymous EGFR c.2317C>T p.H773Y Cac/Tac chr7 55249019 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249019", "IGV") medium 0.222 3703 no call pass 8419 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs767075090 tolerated(0.54) benign(0.102) 74 FFPE ACCCC C/T ACGTG CMDL150129 FLD0351 FLD0375 synonymous EGFR c.2329C>T c.2329C>T(p.%3D) Ctg/Ttg chr7 55249031 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249031", "IGV") medium 0.143 3944 pass no call 12547 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs397517117 likely_benign 62 FFPE GCCGC C/T TGCTG CMDL150129 FLD0351 FLD0375 nonsynonymous EGFR c.2348C>T p.T783I aCc/aTc chr7 55249050 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249050", "IGV") medium 0.229 3944 pass no call 10112 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM14069 deleterious(0) probably_damaging(0.999) 43 FFPE CCTCA C/T CTCCA CMDL150129 FLD0351 FLD0375 nonsynonymous EGFR c.2354C>T p.T785I aCc/aTc chr7 55249056 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249056", "IGV") medium 0.216 1941 pass no call 11653 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM53288, COSM28930 deleterious(0) probably_damaging(1) 37 FFPE CTCCA C/T CGTGC CMDL150129 FLD0351 FLD0375 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.629 0.688 1939 1817 pass pass 46571 48185 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150129 FLD0351 FLD0375 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.630 0.656 1874 1960 pass pass 47271 52583 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150129 FLD0351 FLD0375 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.988 0.986 1958 1785 pass pass 83222 75170 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150129 FLD0351 FLD0375 intron TP53 c.97-32G>A chr17 7579622 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579622", "IGV") medium 0.177 1724 no call pass 4780 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs754228616 46 FFPE GAGGA C/T CAGGT CMDL150129 FLD0351 FLD0375 intron TP53 c.97-47G>A chr17 7579637 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579637", "IGV") low 0.136 1724 no call QD 1935 EXP0116_TP53_E3 ENSG00000141510 3 of 10 61 FFPE AGCCC C/T CCAGC CMDL150129 FLD0351 FLD0375 intron TP53 c.96+55G>A chr17 7579645 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579645", "IGV") medium 0.038 1383 pass no call 4907 EXP0116_TP53_E3 ENSG00000141510 3 of 10 69 FFPE AGCCC C/T CCAGC CMDL150129 FLD0351 FLD0375 intron TP53 c.96+37G>A chr17 7579663 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579663", "IGV") medium 0.192 1724 no call pass 5668 EXP0116_TP53_E3 ENSG00000141510 3 of 10 72 FFPE GTCCC C/T AGCCC CMDL150129 FLD0351 FLD0375 intron TP53 c.96+34G>A chr17 7579666 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579666", "IGV") medium 0.187 1724 no call pass 4155 EXP0116_TP53_E3 ENSG00000141510 3 of 10 69 FFPE CCCAG C/T CCTCC CMDL150129 FLD0351 FLD0375 intron TP53 c.96+33G>A chr17 7579667 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579667", "IGV") low 0.082 1724 no call QD 1152 EXP0116_TP53_E3 ENSG00000141510 3 of 10 68 FFPE CCAGC C/T CTCCA CMDL150129 FLD0351 FLD0375 intron TP53 c.96+24G>A chr17 7579676 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579676", "IGV") medium 0.207 1724 no call pass 5584 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE CAGGT C/T CCCAG CMDL150129 FLD0351 FLD0375 intron TP53 c.96+21G>A chr17 7579679 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579679", "IGV") medium 0.221 0.083 1383 1724 pass QD 5027 546 EXP0116_TP53_E3 ENSG00000141510 3 of 10 56 FFPE GTCCC C/T AGCCC CMDL150129 FLD0351 FLD0375 intron TP53 c.96+18G>A chr17 7579682 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579682", "IGV") medium 0.106 1724 no call pass 4204 EXP0116_TP53_E3 ENSG00000141510 3 of 10 53 FFPE CCCAG C/T CCAAC CMDL150129 FLD0351 FLD0375 splice_donor TP53 c.96+1G>A chr17 7579699 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579699", "IGV") medium 0.215 1383 pass no call 10667 EXP0116_TP53_E3 ENSG00000141510 3 of 10 TP53_g.11219G>T, TP53_g.11219G>A, COSM44435, COSM307275, COSM307277, COSM131538, COSM131539, COSM307276, COSM3717687, COSM3403302, COSM3717686, COSM3403301, COSM307278, COSM131540 36 FFPE CCTTA C/T CAGAA CMDL150129 FLD0351 FLD0375 splice_region,synonymous TP53 c.96G>A c.96G>A(p.%3D) ctG/ctA chr17 7579700 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579700", "IGV") medium 0.195 1724 no call pass 5548 EXP0116_TP53_E3 ENSG00000141510 3 of 11 35 FFPE CTTAC C/T AGAAC CMDL150129 FLD0351 FLD0375 splice_region,intron PTEN c.802-7T>C chr10 89720644 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720644", "IGV") low 0.017 125 LowQual,QD no call 28 PTEN_E00001156315_1m ENSG00000171862 7 of 8 41 FFPE TTTTT T/C TTTTA CMDL150129 FLD0351 FLD0375 splice_region,intron PTEN c.802-6T>C chr10 89720645 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720645", "IGV") low 0.021 84 no call pass 315 PTEN_E00001156315_1m ENSG00000171862 7 of 8 40 FFPE TTTTT T/C TTTAG CMDL150129 FLD0351 FLD0375 nonsynonymous PTEN c.814C>T p.H272Y Cac/Tac chr10 89720663 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720663", "IGV") low 0.111 84 no call pass 302 PTEN_E00001156315_1m ENSG00000171862 8 of 9 COSM5066 deleterious(0.02) benign(0.145) 22 FFPE TGTTT C/T ACTTT CMDL150129 FLD0351 FLD0375 nonsynonymous PTEN c.817T>C p.F273L Ttt/Ctt chr10 89720666 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720666", "IGV") low 0.024 84 no call pass 259 PTEN_E00001156315_1m ENSG00000171862 8 of 9 COSM1349592 deleterious(0.02) possibly_damaging(0.53) 19 FFPE TTCAC T/C TTTGG CMDL150129 FLD0351 FLD0375 splice_region,synonymous PTEN c.492G>A c.492G>A(p.%3D) aaG/aaA chr10 89693008 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89693008", "IGV") low 0.113 1569 no call QD 1781 PTEN_E00001156330_3 ENSG00000171862 5 of 9 rs146629065, COSM1349556 17 FFPE AAAAA G/A GTAAG CMDL150129 FLD0351 FLD0375 nonsynonymous PTEN c.1136A>G p.Y379C tAt/tGt chr10 89725153 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89725153", "IGV") medium 0.252 0.222 4685 4608 pass QD 10569 8989 PTEN_E00001456541_2 ENSG00000171862 9 of 9 tolerated_low_confidence(0.08) probably_damaging(0.986) 65 FFPE TAGAT A/G TTCTG CMDL150129 FLD0351 FLD0375 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") medium 0.997 1531 no call pass 64510 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150129 FLD0351 FLD0375 nonsynonymous TP53 c.581T>G p.L194R cTt/cGt chr17 7578268 A C =hyperlink("http://localhost:60151/goto?locus=chr17:7578268", "IGV") high 0.952 0.961 4750 4675 pass pass 143385 141378 TP53_E00001255919_3 ENSG00000141510 6 of 11 TP53_g.12650T>A, TP53_g.12650del, TP53_g.12650T>C, TP53_g.12650T>G, COSM44571, COSM43827, COSM45205, COSM43623, COSM169019, COSM117650, COSM437525, COSM117647, COSM169018, COSM437526, COSM117648, COSM169020, COSM437528, COSM3675532, COSM3403268, COSM1649391, COSM3675531, COSM117649, COSM437527, COSM169021 deleterious(0) probably_damaging(1) 19 FFPE GGATA A/C GATGC CMDL150129 FLD0351 FLD0375 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") medium 0.178 0.082 1323 1246 pass QD 5968 134 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150129 FLD0351 FLD0375 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") low 0.080 0.126 1324 1250 QD QD 339 1865 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL150129 FLD0351 FLD0375 intron TP53 c.74+47C>T chr17 7579792 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579792", "IGV") low 0.131 2636 QD no call 3890 TP53_E00001596491_1 ENSG00000141510 2 of 10 15 FFPE GCTGG G/A GTTGG CMDL150129 FLD0351 FLD0375 intron TP53 c.74+41C>T chr17 7579798 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579798", "IGV") low 0.117 2476 no call QD 4372 TP53_E00001596491_1 ENSG00000141510 2 of 10 21 FFPE GTTGG G/A GTGGG CMDL150129 FLD0351 FLD0375 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.985 0.993 2636 2476 pass pass 97691 99504 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150129 FLD0351 FLD0375 intron TP53 c.74+35C>T chr17 7579804 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579804", "IGV") low 0.110 0.114 2636 2476 QD QD 592 539 TP53_E00001596491_1 ENSG00000141510 2 of 10 27 FFPE GTGGG G/A GTGGT CMDL150129 FLD0351 FLD0375 intron TP53 c.74+28C>T chr17 7579811 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579811", "IGV") low 0.132 2476 no call QD 1902 TP53_E00001596491_1 ENSG00000141510 2 of 10 34 FFPE TGGTG G/A GCCTG CMDL150129 FLD0351 FLD0375 synonymous TP53 c.30C>T c.30C>T(p.%3D) gtC/gtT chr17 7579883 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579883", "IGV") low 0.107 2476 no call QD 1272 TP53_E00001596491_1 ENSG00000141510 2 of 11 TP53_g.11035C>T, COSM984987, COSM984988, COSM984990, COSM984991 40 FFPE GGCTC G/A ACGCT CMDL150129 FLD0351 FLD0375 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.990 0.994 1538 1491 pass pass 54373 53341 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150129 FLD0351 FLD0375 3_prime_UTR TP53 c.*49C>T chr17 7572878 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572878", "IGV") medium 0.140 1852 pass no call 4967 TP53_E00001757276_1 ENSG00000141510 11 of 11 9 FFPE GGAGG G/A AGAGA CMDL150129 FLD0351 FLD0375 3_prime_UTR TP53 c.*42C>T chr17 7572885 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572885", "IGV") low 0.091 3133 no call QD 1782 TP53_E00001757276_1 ENSG00000141510 11 of 11 16 FFPE GAGAT G/A GGGGT CMDL150129 FLD0351 FLD0375 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.127 3133 no call QD 279 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150129 FLD0351 FLD0375 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.172 0.120 3803 3133 QD pass 5276 7191 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150146 FLD0352 FLD0376 intron EGFR c.2284-56C>T chr7 55248930 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248930", "IGV") medium 0.190 2003 no call pass 9390 EGFR_E00001601336_1 ENSG00000146648 19 of 27 rs41323247 T:0.0038 10 FFPE ATGTG C/T CCCTC CMDL150146 FLD0352 FLD0376 synonymous EGFR c.2289C>T c.2289C>T(p.%3D) gcC/gcT chr7 55248991 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248991", "IGV") low 0.153 4310 QD no call 773 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs117420095 likely_benign G:0.0006 71 FFPE GAAGC C/T TACGT CMDL150146 FLD0352 FLD0376 nonsynonymous EGFR c.2326C>T p.R776C Cgc/Tgc chr7 55249028 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249028", "IGV") low 0.182 4310 QD no call 4242 EGFR_E00001601336_1 ENSG00000146648 20 of 28 CM113961, COSM1716257, COSM6226 deleterious(0) probably_damaging(1) 65 FFPE TGTGC C/T GCCTG CMDL150146 FLD0352 FLD0376 synonymous EGFR c.2328C>T c.2328C>T(p.%3D) cgC/cgT chr7 55249030 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249030", "IGV") low 0.173 3998 no call QD 4019 EGFR_E00001601336_1 ENSG00000146648 20 of 28 rs142999400 63 FFPE TGCCG C/T CTGCT CMDL150146 FLD0352 FLD0376 nonsynonymous EGFR c.2354C>T p.T785I aCc/aTc chr7 55249056 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249056", "IGV") medium 0.173 1946 no call pass 7011 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM53288, COSM28930 deleterious(0) probably_damaging(1) 37 FFPE CTCCA C/T CGTGC CMDL150146 FLD0352 FLD0376 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.196 0.230 2063 1978 pass pass 9762 11917 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150146 FLD0352 FLD0376 nonsynonymous KRAS c.35G>T p.G12V gGt/gTt chr12 25398284 C A =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") high 0.671 0.735 5091 4769 pass pass 83442 83824 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) possibly_damaging(0.479) 26 FFPE CGCCA C/A CAGCT CMDL150146 FLD0352 FLD0376 intron PTEN c.802-143C>T chr10 89720508 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720508", "IGV") low 0.091 1503 QD no call 1159 PTEN_E00001156315_1m ENSG00000171862 7 of 8 28 FFPE TTATT C/T AGAAT CMDL150146 FLD0352 FLD0376 intron PTEN c.802-117G>A chr10 89720534 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720534", "IGV") medium 0.173 1503 pass no call 6470 PTEN_E00001156315_1m ENSG00000171862 7 of 8 54 FFPE ATTTT G/A TTGAC CMDL150146 FLD0352 FLD0376 intron PTEN c.801+22G>A chr10 89717798 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717798", "IGV") low 0.097 1891 no call QD 1432 PTEN_E00001156321_4m ENSG00000171862 7 of 8 29 FFPE CATTG G/A GAGAA CMDL150146 FLD0352 FLD0376 intron PTEN c.801+130G>A chr10 89717906 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89717906", "IGV") low 0.106 2096 QD no call 1613 PTEN_E00001156321_4m ENSG00000171862 7 of 8 28 FFPE CTCTG G/A CATTG CMDL150146 FLD0352 FLD0376 synonymous PTEN c.360A>G c.360A>G(p.%3D) gcA/gcG chr10 89692876 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89692876", "IGV") low 0.116 1727 QD no call 2161 PTEN_E00001156330_3 ENSG00000171862 5 of 9 rs759485888 benign 13 FFPE GTTGC A/G GCAAT CMDL150146 FLD0352 FLD0376 intron PTEN c.492+11T>C chr10 89693019 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89693019", "IGV") low 0.092 1682 no call QD 277 PTEN_E00001156330_3 ENSG00000171862 5 of 8 6 FFPE TTATT T/C TTTGA CMDL150146 FLD0352 FLD0376 intron TP53 c.74+53C>T chr17 7579786 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579786", "IGV") medium 0.138 1246 no call pass 2948 TP53_E00001596491_1 ENSG00000141510 2 of 10 9 FFPE TAGGG G/A GCTGG CMDL150146 FLD0352 FLD0376 intron TP53 c.74+47C>T chr17 7579792 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579792", "IGV") medium 0.229 2470 no call pass 8617 TP53_E00001596491_1 ENSG00000141510 2 of 10 15 FFPE GCTGG G/A GTTGG CMDL150146 FLD0352 FLD0376 intron TP53 c.74+42C>T chr17 7579797 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579797", "IGV") medium 0.205 3106 pass no call 6983 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs767153311 20 FFPE GGTTG G/A GGTGG CMDL150146 FLD0352 FLD0376 intron TP53 c.74+40C>T chr17 7579799 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579799", "IGV") medium 0.243 2470 no call pass 18665 TP53_E00001596491_1 ENSG00000141510 2 of 10 22 FFPE TTGGG G/A TGGGG CMDL150146 FLD0352 FLD0376 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.610 0.623 3106 2470 pass pass 53171 47001 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150146 FLD0352 FLD0376 intron TP53 c.74+37C>T chr17 7579802 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579802", "IGV") low 0.155 2470 no call QD 2377 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs749212949 25 FFPE GGGTG G/A GGGTG CMDL150146 FLD0352 FLD0376 intron TP53 c.74+28C>T chr17 7579811 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579811", "IGV") medium 0.196 3106 pass no call 6705 TP53_E00001596491_1 ENSG00000141510 2 of 10 34 FFPE TGGTG G/A GCCTG CMDL150146 FLD0352 FLD0376 intron TP53 c.74+23C>T chr17 7579816 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579816", "IGV") medium 0.215 2470 no call pass 6686 TP53_E00001596491_1 ENSG00000141510 2 of 10 39 FFPE GGCCT G/A CCCTT CMDL150146 FLD0352 FLD0376 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.743 0.847 893 884 pass pass 17503 21554 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150146 FLD0352 FLD0376 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.223 2946 QD no call 3411 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150146 FLD0352 FLD0376 3_prime_UTR TP53 c.*35C>T chr17 7572892 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572892", "IGV") medium 0.168 3620 no call pass 8743 TP53_E00001757276_1 ENSG00000141510 11 of 11 23 FFPE GGGTG G/A GAGGC CMDL150146 FLD0352 FLD0376 3_prime_UTR TP53 c.*20C>T chr17 7572907 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572907", "IGV") low 0.146 3620 no call QD 3076 TP53_E00001757276_1 ENSG00000141510 11 of 11 38 FFPE AGTGG G/A GAACA CMDL150146 FLD0352 FLD0376 splice_acceptor TP53 c.1101-2A>C chr17 7573010 T G =hyperlink("http://localhost:60151/goto?locus=chr17:7573010", "IGV") low 0.345 1843 no call QD 2087 TP53_E00001757276_1 ENSG00000141510 10 of 10 rs587781664, CS111031, TP53_g.17908A>G, TP53_g.17908A>T, TP53_g.17908A>C, COSM1191161, COSM12663, COSM45409, COSM1386548, COSM1679487 1 FFPE GTGGC T/G GTAGG CMDL150148 FLD0353 FLD0377 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.257 0.224 2671 2373 pass pass 18093 13576 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150148 FLD0353 FLD0377 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.271 0.294 2335 2034 pass pass 15641 15099 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150148 FLD0353 FLD0377 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.279 0.250 2497 2208 pass pass 17559 13670 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150148 FLD0353 FLD0377 nonsynonymous TP53 c.422G>A p.C141Y tGc/tAc chr17 7578508 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578508", "IGV") high 0.903 0.895 4110 4245 pass pass 117164 118339 TP53_E00001255919_6 ENSG00000141510 5 of 11 rs587781288, CM993216, TP53_g.12410G>T, TP53_g.12410G>A, TP53_g.12410G>C, COSM293910, COSM44911, COSM43708, COSM1559491, COSM131470, COSM293912, COSM1559492, COSM131471, COSM293911, COSM131473, COSM293913, COSM1559494, COSM3378367, COSM3378366, COSM131472, COSM293914, COSM1559493 deleterious(0) probably_damaging(1) pathogenic 64 FFPE CAGGG C/T AGGTC CMDL150148 FLD0353 FLD0377 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.994 0.991 3143 2756 pass pass 98624 89793 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150148 FLD0353 FLD0377 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.990 0.995 2485 2278 pass pass 75969 69380 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150153 FLD0354 FLD0378 nonsynonymous,splice_region EGFR c.2284G>A p.E762K Gaa/Aaa chr7 55248986 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55248986", "IGV") medium 0.238 3434 pass no call 9759 EGFR_E00001601336_1 ENSG00000146648 20 of 28 deleterious(0) probably_damaging(1) 66 FFPE TCCAG G/A AAGCC CMDL150153 FLD0354 FLD0378 nonsynonymous EGFR c.2315C>T p.P772L cCc/cTc chr7 55249017 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55249017", "IGV") medium 0.476 3434 pass no call 35444 EGFR_E00001601336_1 ENSG00000146648 20 of 28 COSM115794 deleterious(0) probably_damaging(0.986) 76 FFPE CAACC C/T CCACG CMDL150153 FLD0354 FLD0378 nonsynonymous EGFR c.2323T>A p.C775S Tgc/Agc chr7 55249025 T A =hyperlink("http://localhost:60151/goto?locus=chr7:55249025", "IGV") medium 0.233 3434 pass no call 9644 EGFR_E00001601336_1 ENSG00000146648 20 of 28 tolerated(0.41) probably_damaging(0.992) 68 FFPE ACGTG T/A GCCGC CMDL150153 FLD0354 FLD0378 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.426 0.516 1822 1847 pass pass 26030 34817 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150153 FLD0354 FLD0378 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.997 0.996 1641 1880 pass pass 70538 81194 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150153 FLD0354 FLD0378 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.645 0.565 4350 4451 pass pass 64360 54170 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150153 FLD0354 FLD0378 intron TP53 c.97-45G>A chr17 7579635 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579635", "IGV") medium 0.401 617 pass no call 6268 EXP0116_TP53_E3 ENSG00000141510 3 of 10 59 FFPE TCAGC C/T CCCCA CMDL150153 FLD0354 FLD0378 nonsynonymous PIK3CA c.1556G>A p.R519K aGa/aAa chr3 178936014 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936014", "IGV") medium 0.212 1647 pass no call 3438 PIK3CA_Ex10_gap ENSG00000121879 10 of 21 tolerated(1) benign(0.003) 50 FFPE AGCTA G/A AGACA CMDL150153 FLD0354 FLD0378 intron PTEN c.802-29C>T chr10 89720622 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89720622", "IGV") low 0.272 100 no call QD 141 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs759473017, COSM5917 63 FFPE CATTT C/T TTTTT CMDL150153 FLD0354 FLD0378 intron PTEN c.802-13T>C chr10 89720638 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720638", "IGV") low 0.019 100 no call QD 79 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs540097879 C:0.0002 47 FFPE CTTTT T/C TTTTT CMDL150153 FLD0354 FLD0378 nonsynonymous PTEN c.443C>T p.A148V gCa/gTa chr10 89692959 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692959", "IGV") low 0.171 3146 QD no call 1890 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM23660 deleterious(0.03) benign(0.394) 66 FFPE AAAGG C/T ACAAG CMDL150153 FLD0354 FLD0378 synonymous PTEN c.454C>T c.454C>T(p.%3D) Cta/Tta chr10 89692970 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89692970", "IGV") low 0.218 3172 no call QD 5245 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM1349547, COSM5180, COSM1349546 55 FFPE AGGCC C/T TAGAT CMDL150153 FLD0354 FLD0378 nonsynonymous PTEN c.485A>T p.D162V gAc/gTc chr10 89693001 A T =hyperlink("http://localhost:60151/goto?locus=chr10:89693001", "IGV") medium 0.146 1566 no call pass 4395 PTEN_E00001156330_3 ENSG00000171862 5 of 9 COSM23658, COSM1167954 deleterious(0) probably_damaging(0.925) 24 FFPE CAGAG A/T CAAAA CMDL150153 FLD0354 FLD0378 splice_region,synonymous PTEN c.492G>A c.492G>A(p.%3D) aaG/aaA chr10 89693008 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89693008", "IGV") low 0.103 1533 QD no call 1632 PTEN_E00001156330_3 ENSG00000171862 5 of 9 rs146629065, COSM1349556 17 FFPE AAAAA G/A GTAAG CMDL150153 FLD0354 FLD0378 splice_region,intron PTEN c.492+4A>G chr10 89693012 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89693012", "IGV") low 0.082 1566 no call QD 94 PTEN_E00001156330_3 ENSG00000171862 5 of 8 13 FFPE AGGTA A/G GTTAT CMDL150153 FLD0354 FLD0378 nonsynonymous PTEN c.88C>T p.P30S Cca/Tca chr10 89653790 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653790", "IGV") low 0.171 4087 no call QD 4717 PTEN_E00001156351_1 ENSG00000171862 2 of 9 tolerated(0.08) benign(0.186) 23 FFPE TTTAT C/T CAAAC CMDL150153 FLD0354 FLD0378 nonsynonymous PTEN c.113C>T p.P38L cCt/cTt chr10 89653815 C T =hyperlink("http://localhost:60151/goto?locus=chr10:89653815", "IGV") low 0.146 4087 no call QD 2504 PTEN_E00001156351_1 ENSG00000171862 2 of 9 COSM249828, COSM3736937 deleterious(0) probably_damaging(0.997) 48 FFPE ATTTC C/T TGCAG CMDL150153 FLD0354 FLD0378 intron PTEN c.164+25T>C chr10 89653891 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89653891", "IGV") low 0.099 2044 no call QD 838 PTEN_E00001156351_1 ENSG00000171862 2 of 8 6 FFPE CTATT T/C CAAAT CMDL150153 FLD0354 FLD0378 intron TP53 c.74+53C>T chr17 7579786 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579786", "IGV") medium 0.150 1384 no call pass 3958 TP53_E00001596491_1 ENSG00000141510 2 of 10 9 FFPE TAGGG G/A GCTGG CMDL150153 FLD0354 FLD0378 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.995 0.996 2300 2771 pass pass 78797 103999 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150153 FLD0354 FLD0378 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") medium 0.223 2771 no call pass 6112 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL150153 FLD0354 FLD0378 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.994 0.988 1125 1138 pass pass 38693 38615 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150153 FLD0354 FLD0378 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.108 2975 no call QD 394 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 FFPE GATGG G/A GGTGG CMDL150153 FLD0354 FLD0378 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") medium 0.166 3026 pass no call 6705 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150153 FLD0354 FLD0378 3_prime_UTR TP53 c.*38C>T chr17 7572889 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572889", "IGV") medium 0.174 0.164 3026 2975 pass QD 13307 778 TP53_E00001757276_1 ENSG00000141510 11 of 11 rs759018180 20 FFPE TGGGG G/A TGGGA CMDL150153 FLD0354 FLD0378 3_prime_UTR TP53 c.*5C>T chr17 7572922 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572922", "IGV") low 0.191 3026 QD no call 4764 TP53_E00001757276_1 ENSG00000141510 11 of 11 53 FFPE GTGGA G/A AATGT CMDL150200 FLD0355 FLD0379 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.508 0.455 2381 2347 pass pass 42466 36549 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150200 FLD0355 FLD0379 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.531 0.551 2026 2123 pass pass 41093 44483 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150200 FLD0355 FLD0379 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.992 0.996 2202 2165 pass pass 92655 92294 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150200 FLD0355 FLD0379 synonymous EGFR c.2982C>T c.2982C>T(p.%3D) gaC/gaT chr7 55268916 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268916", "IGV") high 0.466 0.482 4924 4775 pass pass 40831 41439 EGFR_E00001801208_1 19641380, 19372140, 25396734, 22552271, 17956637, 19190167, 25127363, 19201048, 21859544, 23313300, 23816762, 23790025, 24454509, 23555641 ENSG00000146648 25 of 28 rs2293347, COSM3762773 T:0.1418 52 FFPE ACAGA C/T TCCAA CMDL150200 FLD0355 FLD0379 nonsynonymous PIK3CA c.1633G>A p.E545K Gag/Aag chr3 178936091 G A =hyperlink("http://localhost:60151/goto?locus=chr3:178936091", "IGV") high 0.358 0.363 1854 2005 pass pass 10110 12058 PIK3CA_Ex10_gap 21264207 ENSG00000121879 10 of 21 rs104886003, COSM763, COSM27133, COSM125370, COSM295672 deleterious(0.02) probably_damaging(0.959) not_provided,pathogenic 36 FFPE TCACT G/A AGCAG CMDL150200 FLD0355 FLD0379 intron PTEN c.802-14T>C chr10 89720637 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720637", "IGV") low 0.018 129 no call LowQual,QD 15 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs775342006 48 FFPE TCTTT T/C TTTTT CMDL150200 FLD0355 FLD0379 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.101 1452 no call QD 1177 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150202 FLD0356 FLD0380 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.984 0.988 2236 2038 pass pass 95208 86827 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150202 FLD0356 FLD0380 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.995 0.994 2068 1950 pass pass 97801 93213 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150202 FLD0356 FLD0380 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.996 0.995 2085 2056 pass pass 89424 87792 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150202 FLD0356 FLD0380 intron TP53 c.97-25G>A chr17 7579615 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579615", "IGV") medium 0.210 1716 pass no call 6811 EXP0116_TP53_E3 ENSG00000141510 3 of 10 39 FFPE GCAGT C/T AGAGG CMDL150202 FLD0356 FLD0380 intron TP53 c.97-38G>A chr17 7579628 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579628", "IGV") medium 0.228 1716 pass no call 7057 EXP0116_TP53_E3 ENSG00000141510 3 of 10 52 FFPE CAGGT C/T CTCAG CMDL150202 FLD0356 FLD0380 intron TP53 c.97-39G>A chr17 7579629 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579629", "IGV") medium 0.234 1716 pass no call 14740 EXP0116_TP53_E3 ENSG00000141510 3 of 10 53 FFPE AGGTC C/T TCAGC CMDL150202 FLD0356 FLD0380 intron TP53 c.97-46G>A chr17 7579636 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579636", "IGV") medium 0.366 1716 pass no call 22712 EXP0116_TP53_E3 ENSG00000141510 3 of 10 rs138445402 60 FFPE CAGCC C/T CCCAG CMDL150202 FLD0356 FLD0380 intron TP53 c.96+32G>A chr17 7579668 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579668", "IGV") medium 0.332 1716 pass no call 14712 EXP0116_TP53_E3 ENSG00000141510 3 of 10 67 FFPE CAGCC C/T TCCAG CMDL150202 FLD0356 FLD0380 splice_region,intron TP53 c.96+5G>A chr17 7579695 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579695", "IGV") low 0.099 1716 QD no call 209 EXP0116_TP53_E3 ENSG00000141510 3 of 10 40 FFPE TTGTC C/T TTACC CMDL150202 FLD0356 FLD0380 intron TP53 c.672+63G>A chr17 7578114 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578114", "IGV") low 0.015 1330 no call QD 1168 TP53_E00001255919_1 ENSG00000141510 6 of 10 5 FFPE CTCAC C/T TGGAG CMDL150202 FLD0356 FLD0380 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.993 1330 no call QD 1172 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 FFPE TCACC T/C GGAGG CMDL150202 FLD0356 FLD0380 intron TP53 c.74+55C>T chr17 7579784 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579784", "IGV") low 0.102 1474 QD no call 1661 TP53_E00001596491_1 ENSG00000141510 2 of 10 7 FFPE GCTAG G/A GGGCT CMDL150202 FLD0356 FLD0380 intron TP53 c.74+54C>T chr17 7579785 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579785", "IGV") low 0.102 1360 no call QD 1671 TP53_E00001596491_1 ENSG00000141510 2 of 10 8 FFPE CTAGG G/A GGCTG CMDL150202 FLD0356 FLD0380 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.995 0.995 2952 2723 pass pass 104076 98226 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150202 FLD0356 FLD0380 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.996 0.991 1864 1670 pass pass 63679 57415 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150202 FLD0356 FLD0380 3_prime_UTR TP53 c.*39C>T chr17 7572888 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572888", "IGV") low 0.154 0.200 4236 3803 QD QD 5001 7152 TP53_E00001757276_1 ENSG00000141510 11 of 11 19 FFPE ATGGG G/A GTGGG CMDL150209 FLD0357 FLD0381 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.986 0.986 2370 2466 pass pass 99882 103427 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150209 FLD0357 FLD0381 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.995 0.992 2095 2192 pass pass 94062 101036 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150209 FLD0357 FLD0381 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.993 0.994 2127 2324 pass pass 89957 98319 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150209 FLD0357 FLD0381 nonsynonymous KRAS c.34G>A p.G12S Ggt/Agt chr12 25398285 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398285", "IGV") high 0.600 0.589 5029 5025 pass pass 64827 63270 KRAS_AA_HS ENSG00000133703 2 of 6 CM076251, COSM518, COSM517, COSM516, COSM1152506, COSM1157797, COSM1140136 deleterious(0.03) possibly_damaging(0.644) 25 FFPE GCCAC C/T AGCTC CMDL150209 FLD0357 FLD0381 intron PTEN c.802-12T>C chr10 89720639 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720639", "IGV") low 0.013 128 QD no call 90 PTEN_E00001156315_1m ENSG00000171862 7 of 8 rs587781129 benign 46 FFPE TTTTT T/C TTTTT CMDL150209 FLD0357 FLD0381 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.996 0.991 3062 3077 pass pass 100286 99166 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150209 FLD0357 FLD0381 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.995 0.987 2278 2567 pass pass 71477 78786 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA CMDL150226 FLD0358 FLD0382 nonsynonymous BRAF c.1799T>A p.V600E gTg/gAg chr7 140453136 A T =hyperlink("http://localhost:60151/goto?locus=chr7:140453136", "IGV") high 0.536 0.518 5510 5052 pass pass 56343 51170 BRAF_AA_HS ENSG00000157764 15 of 18 CM112509, COSM476, COSM6137, COSM18443 deleterious(0) probably_damaging(0.967) 10 FFPE ATTTC A/T CTGTA CMDL150226 FLD0358 FLD0382 intron EGFR c.2284-42C>T chr7 55248944 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248944", "IGV") low 0.086 2053 QD no call 1422 EGFR_E00001601336_1 ENSG00000146648 19 of 27 24 FFPE CTGGC C/T ACCAT CMDL150226 FLD0358 FLD0382 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.987 0.986 2344 1954 pass pass 99008 82510 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 FFPE GTGCA G/A CTCAT CMDL150226 FLD0358 FLD0382 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.996 0.991 2048 1704 pass pass 95020 79977 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 FFPE GTGCA G/A CTCAT CMDL150226 FLD0358 FLD0382 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.987 0.988 2060 1811 pass pass 86673 76516 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 FFPE GTGAC T/C GTTTG CMDL150226 FLD0358 FLD0382 intron TP53 c.97-29C>A chr17 7579619 G T =hyperlink("http://localhost:60151/goto?locus=chr17:7579619", "IGV") high 0.633 0.424 1614 1349 pass pass 21791 11482 EXP0116_TP53_E3 18849522, 19222838, 19426493, 22962577, 21869887, 19386249 ENSG00000141510 3 of 10 rs17883323 T:0.0777 43 FFPE TCAGA G/T GACCA CMDL150226 FLD0358 FLD0382 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.538 0.602 2764 2489 pass pass 32045 35899 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 FFPE GGGGT G/C GGGGT CMDL150226 FLD0358 FLD0382 intron TP53 c.74+34C>T chr17 7579805 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579805", "IGV") low 0.117 2489 no call QD 100 TP53_E00001596491_1 ENSG00000141510 2 of 10 rs758434025 28 FFPE TGGGG G/A TGGTG CMDL150226 FLD0358 FLD0382 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.805 0.786 1554 1333 pass pass 32618 27736 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 FFPE CCACG G/C GGGGA STD2_011 FLD0359 FLD0383 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.434 0.376 1792 2559 pass pass 26037 30745 EGFR_E00001601336_1 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 30 Control GTGCA G/A CTCAT STD2_011 FLD0359 FLD0383 synonymous EGFR c.2361G>A c.2361G>A(p.%3D) caG/caA chr7 55249063 G A =hyperlink("http://localhost:60151/goto?locus=chr7:55249063", "IGV") high 0.456 0.418 1510 2077 pass pass 23118 28066 EGFR_E00001601336_2 17956637, 17875215, 19563658, 23450128, 19201048, 23790025, 23675485, 24838331, 24454509, 24934485, 23555641, 17626639, 25411647, 22252115, 21869887, 21457545 ENSG00000146648 20 of 28 rs1050171, CM067987, COSM1451600 benign A:0.4327 42 Control GTGCA G/A CTCAT STD2_011 FLD0359 FLD0383 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") high 0.515 0.469 1555 2218 pass pass 28514 36930 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 Control GTGAC T/C GTTTG STD2_011 FLD0359 FLD0383 nonsynonymous EGFR c.3046T>C p.Y1016H Tac/Cac chr7 55268980 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55268980", "IGV") low 0.158 0.176 3383 4436 QD QD 960 2508 EGFR_E00001801208_2 ENSG00000146648 25 of 28 deleterious(0) probably_damaging(0.997) 42 Control ACGAG T/C ACCTC STD2_011 FLD0359 FLD0383 nonsynonymous KRAS c.38G>A p.G13D gGc/gAc chr12 25398281 C T =hyperlink("http://localhost:60151/goto?locus=chr12:25398281", "IGV") high 0.239 0.256 3679 5053 pass pass 8349 14101 KRAS_AA_HS ENSG00000133703 2 of 6 COSM533, COSM532, COSM534, COSM1152504, COSM1140132, COSM3384257 deleterious(0.04) possibly_damaging(0.506) 29 Control CTACG C/T CACCA STD2_011 FLD0359 FLD0383 nonsynonymous PIK3CA c.3140A>G p.H1047R cAt/cGt chr3 178952085 A G =hyperlink("http://localhost:60151/goto?locus=chr3:178952085", "IGV") high 0.277 0.287 3542 4861 pass pass 11357 17721 PIK3CA_Exn21_gap 25710561 ENSG00000121879 21 of 21 rs121913279, COSM776, COSM775, COSM249874, COSM94987, COSM94986 tolerated(0.11) possibly_damaging(0.529) pathogenic 28 Control TGCAC A/G TCATG STD2_011 FLD0359 FLD0383 intron PTEN c.802-11T>C chr10 89720640 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89720640", "IGV") low 0.062 0.056 468 659 QD QD 320 434 PTEN_E00001156315_1m ENSG00000171862 7 of 8 45 Control TTTTT T/C TTTTT STD2_011 FLD0359 FLD0383 splice_region,intron TP53 c.376-7C>T chr17 7578561 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578561", "IGV") low 0.171 0.176 3344 4437 QD QD 2799 4359 TP53_E00001255919_6 ENSG00000141510 4 of 10 13 Control TGTAG G/A AAGAG STD2_011 FLD0359 FLD0383 intron TP53 c.74+38C>G chr17 7579801 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579801", "IGV") high 0.913 0.955 2045 2592 pass pass 48833 68427 TP53_E00001596491_1 18798306, 21437228, 17096406, 19276375, 19423538, 21115003, 25269805, 24336192, 24936644, 21402718, 23570263, 22962577, 22829934, 18248785, 17133269 ENSG00000141510 2 of 10 rs1642785 benign G:0.4151 24 Control GGGGT G/C GGGGT STD2_011 FLD0359 FLD0383 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") high 0.991 0.991 1507 2257 pass pass 41814 63728 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 Control CCACG G/C GGGGA NTC_011 FLD0360 FLD0384 intron EGFR c.2284-62C>T chr7 55248924 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55248924", "IGV") low 0.600 5 pass no call 83 EGFR_E00001601336_1 ENSG00000146648 19 of 27 4 Blank GGGTC C/T ATGTG NTC_011 FLD0360 FLD0384 nonsynonymous EGFR c.2560A>G p.T854A Aca/Gca chr7 55259502 A G =hyperlink("http://localhost:60151/goto?locus=chr7:55259502", "IGV") low 0.111 17 LowQual,QD no call 11 EGFR_E00001681524_2 ENSG00000146648 21 of 28 COSM28537, COSM1235378 tolerated(0.1) possibly_damaging(0.6) 70 Blank AGATC A/G CAGAT NTC_011 FLD0360 FLD0384 nonsynonymous EGFR c.2566T>C p.F856L Ttt/Ctt chr7 55259508 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55259508", "IGV") low 0.111 17 LowQual,QD no call 11 EGFR_E00001681524_2 ENSG00000146648 21 of 28 deleterious(0.01) probably_damaging(0.999) 64 Blank CAGAT T/C TTGGG NTC_011 FLD0360 FLD0384 synonymous EGFR c.2709T>C c.2709T>C(p.%3D) acT/acC chr7 55266417 T C =hyperlink("http://localhost:60151/goto?locus=chr7:55266417", "IGV") low 0.538 13 pass no call 232 EGFR_E00001779947_1 19372140, 25396734, 17956637, 22199994, 24454509, 23555641, 22536362, 17626639, 21869887 ENSG00000146648 23 of 28 rs1140475 benign T:0.0833 34 Blank GTGAC T/C GTTTG NTC_011 FLD0360 FLD0384 synonymous EGFR c.3027C>T c.3027C>T(p.%3D) gaC/gaT chr7 55268961 C T =hyperlink("http://localhost:60151/goto?locus=chr7:55268961", "IGV") low 0.333 10 pass no call 41 EGFR_E00001801208_2 ENSG00000146648 25 of 28 rs754193639 23 Blank GACGA C/T GTGGT NTC_011 FLD0360 FLD0384 nonsynonymous KRAS c.35G>T p.G12V gGt/gTt chr12 25398284 C A =hyperlink("http://localhost:60151/goto?locus=chr12:25398284", "IGV") low 0.375 16 pass no call 73 KRAS_AA_HS ENSG00000133703 2 of 6 CM087372, COSM520, COSM521, COSM522, COSM12657, COSM1140133, COSM1135366, COSM1140134 deleterious(0) possibly_damaging(0.479) 26 Blank CGCCA C/A CAGCT NTC_011 FLD0360 FLD0384 nonsynonymous PTEN c.982G>A p.A328T Gca/Aca chr10 89720831 G A =hyperlink("http://localhost:60151/goto?locus=chr10:89720831", "IGV") low 0.500 12 pass no call 84 PTEN_E00001156315_7 ENSG00000171862 8 of 9 deleterious(0) probably_damaging(0.992) 65 Blank ACAAA G/A CAAAT NTC_011 FLD0360 FLD0384 nonsynonymous PTEN c.667A>G p.K223E Aag/Gag chr10 89717642 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89717642", "IGV") low 1.000 2 no call LowQual 22 PTEN_E00001156321_1 ENSG00000171862 7 of 9 COSM5858 tolerated(0.06) benign(0.173) 65 Blank AGGTG A/G AGATA NTC_011 FLD0360 FLD0384 synonymous PTEN c.225T>C c.225T>C(p.%3D) caT/caC chr10 89690818 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89690818", "IGV") low 1.000 2 no call LowQual 22 PTEN_E00001156337_4 ENSG00000171862 4 of 9 10 Blank AGACA T/C TATGA NTC_011 FLD0360 FLD0384 synonymous PTEN c.150T>C c.150T>C(p.%3D) atT/atC chr10 89653852 T C =hyperlink("http://localhost:60151/goto?locus=chr10:89653852", "IGV") low 0.300 20 pass no call 101 PTEN_E00001156351_1 ENSG00000171862 2 of 9 CD110172 45 Blank AATAT T/C GATGA NTC_011 FLD0360 FLD0384 nonsynonymous PTEN c.20A>G p.E7G gAg/gGg chr10 89624246 A G =hyperlink("http://localhost:60151/goto?locus=chr10:89624246", "IGV") low 0.118 34 no call LowQual,QD 10 PTEN_E00001456562_1 ENSG00000171862 1 of 9 COSM1349461 tolerated(0.52) benign(0.001) 52 Blank CAAAG A/G GATCG NTC_011 FLD0360 FLD0384 intron TP53 c.672+62A>G chr17 7578115 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7578115", "IGV") low 0.800 5 pass no call 128 TP53_E00001255919_1 19276285, 18854777, 12466288, 22829776, 16465622, 17908995, 17428325, 17151932, 24818791, 18798306, 17301252, 17449902, 17624591, 18640487, 19193430, 19276375, 19423538, 19426493, 19505915, 21810023, 21838531, 23360829, 25430047, 21402718, 16039051, 18314326, 21869887, 19386249 ENSG00000141510 6 of 10 rs1625895 T:0.1663 6 Blank TCACC T/C GGAGG NTC_011 FLD0360 FLD0384 intron TP53 c.672+27G>A chr17 7578150 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578150", "IGV") low 0.200 10 pass no call 32 TP53_E00001255919_1 ENSG00000141510 6 of 10 41 Blank CTCCT C/T CCAGA NTC_011 FLD0360 FLD0384 intron TP53 c.672+26G>A chr17 7578151 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7578151", "IGV") low 0.200 10 pass no call 32 TP53_E00001255919_1 ENSG00000141510 6 of 10 TP53_g.12767G>A, COSM45557 42 Blank TCCTC C/T CAGAG NTC_011 FLD0360 FLD0384 stop_gained TP53 c.493C>T p.Q165* Cag/Tag chr17 7578437 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7578437", "IGV") low 1.000 2 no call LowQual 22 TP53_E00001255919_5 ENSG00000141510 5 of 11 rs730882001, TP53_g.12481C>G, TP53_g.12481C>T, COSM43632, COSM45879, COSM1172488, COSM1172489, COSM1172491, COSM3388213, COSM3388212, COSM1172490 pathogenic 59 Blank TGACT G/A CTTGT NTC_011 FLD0360 FLD0384 intron TP53 c.74+36C>T chr17 7579803 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579803", "IGV") low 0.750 8 pass no call 96 TP53_E00001596491_1 ENSG00000141510 2 of 10 26 Blank GGTGG G/A GGTGG NTC_011 FLD0360 FLD0384 stop_gained TP53 c.46C>T p.Q16* Cag/Tag chr17 7579867 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7579867", "IGV") low 0.500 8 pass no call 47 TP53_E00001596491_1 ENSG00000141510 2 of 11 COSM100007, COSM100010, COSM100008, COSM100009 56 Blank TTCCT G/A ACTCA NTC_011 FLD0360 FLD0384 intron TP53 c.375+22G>A chr17 7579290 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579290", "IGV") low 0.133 12 LowQual no call 26 TP53_E00001612188_1 ENSG00000141510 4 of 10 11 Blank GGAAG C/T CAGCC NTC_011 FLD0360 FLD0384 nonsynonymous,splice_region TP53 c.373A>G p.T125A Acg/Gcg chr17 7579314 T C =hyperlink("http://localhost:60151/goto?locus=chr17:7579314", "IGV") low 0.133 12 LowQual no call 26 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11604A>G, TP53_g.11604del, TP53_g.11604A>C, COSM44995, COSM45368, COSM46069, COSM707862, COSM1386830, COSM707863, COSM1386831, COSM3970385, COSM1646886 deleterious(0) probably_damaging(0.921) 35 Blank GACCG T/C GCAAG NTC_011 FLD0360 FLD0384 synonymous TP53 c.360G>A c.360G>A(p.%3D) aaG/aaA chr17 7579327 C T =hyperlink("http://localhost:60151/goto?locus=chr17:7579327", "IGV") low 0.200 12 LowQual no call 26 TP53_E00001612188_1 ENSG00000141510 4 of 11 TP53_g.11591G>T, COSM27173, COSM2744987, COSM2744989, COSM3937615, COSM2744988 48 Blank ACAGA C/T TTGGC NTC_011 FLD0360 FLD0384 nonsynonymous TP53 c.215C>G p.P72R cCc/cGc chr17 7579472 G C =hyperlink("http://localhost:60151/goto?locus=chr17:7579472", "IGV") low 1.000 6 pass no call 120 TP53_E00001612188_2 18805939, 24944790, 18547414, 22076708, 18191955, 18854777, 24084248, 20436704, 18715757, 18820009, 19911060, 24728327, 18678618, 21283750, 19237173, 20587610, 16465622, 19750108, 23311506, 21790896, 19224585, 20455025, 24586820, 24944814, 18990748, 19822020, 16857995, 23906684, 15564288, 19367277, 20232390, 18978339, 18298806, 20452958, 17428325, 20003265, 25412941, 24654968, 24820515, 19286843, 24818791, 19482343, 18798306, 21437228, 19470478, 22773013, 23837945, 23034890, 15450681, 16287156, 17096406, 17301252, 17449902, 17537232, 17624591, 18433491, 18640487, 19193430, 19276375, 19423538, 19426493, 19471604, 19505915, 19521721, 19542078, 19625214, 19657586, 19707196, 19784392, 19834951, 19837266, 20110284, 20127253, 20357201, 20512840, 20593380, 20935061, 21029772, 21115003, 21146886, 21252575, 21708280, 21741128, 21810023, 21838531, 21841506, 21897271, 22178231, 22189267, 22251423, 22294769, 22336942, 22417303, 22892830, 23124483, 23125046, 23192612, 23207172, 23210739, 23360829, 23423487, 23632240, 23653000, 23729685, 23744327, 24115240, 24266512, 24369748, 24370206, 24435975, 24534481, 24632578, 24710610, 2486394 ENSG00000141510 4 of 11 rs1042522, CM961374, TP53_g.11446del, COSM250061, COSM45985, COSM3766190, COSM3766193, COSM3766192, COSM3766191 tolerated(0.57) benign(0.143) uncertain_significance,benign G:0.4571 29 Blank CCACG G/C GGGGA NTC_011 FLD0360 FLD0384 synonymous TP53 c.765C>T c.765C>T(p.%3D) atC/atT chr17 7577516 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577516", "IGV") low 0.200 10 pass no call 32 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13402C>T, TP53_g.13402C>A, TP53_g.13402C>G, COSM46040, COSM45104, COSM45580 67 Blank AGTGT G/A ATGAT NTC_011 FLD0360 FLD0384 nonsynonymous TP53 c.760A>T p.I254F Atc/Ttc chr17 7577521 T A =hyperlink("http://localhost:60151/goto?locus=chr17:7577521", "IGV") low 0.200 10 pass no call 32 TP53_E00001665758_1 ENSG00000141510 7 of 11 rs746601313, TP53_g.13397A>C, TP53_g.13397del, TP53_g.13397A>T, TP53_g.13397A>G, COSM45647, COSM44030, COSM44430, COSM1579892, COSM1579893, COSM307260, COSM1579894, COSM307259 deleterious(0) probably_damaging(0.979) 72 Blank GATGA T/A GGTGA NTC_011 FLD0360 FLD0384 nonsynonymous TP53 c.758C>T p.T253I aCc/aTc chr17 7577523 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577523", "IGV") low 0.200 10 pass no call 32 TP53_E00001665758_1 ENSG00000141510 7 of 11 TP53_g.13395C>G, TP53_g.13395C>T, TP53_g.13395C>A, COSM44993, COSM43683, COSM4070036, COSM307262, COSM307261, COSM4070039, COSM4070038, COSM4070037 deleterious(0) probably_damaging(1) 74 Blank TGATG G/A TGAGG NTC_011 FLD0360 FLD0384 nonsynonymous TP53 c.755T>C p.L252P cTc/cCc chr17 7577526 A G =hyperlink("http://localhost:60151/goto?locus=chr17:7577526", "IGV") low 0.200 10 pass no call 32 TP53_E00001665758_1 ENSG00000141510 7 of 11 CM900212, rs121912653, TP53_g.13392T>A, TP53_g.13392T>C, COSM44769, COSM45091, COSM148175, COSM148174 deleterious(0) probably_damaging(1) pathogenic 77 Blank TGGTG A/G GGATG NTC_011 FLD0360 FLD0384 nonsynonymous TP53 c.749C>T p.P250L cCc/cTc chr17 7577532 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7577532", "IGV") low 0.200 10 pass no call 32 TP53_E00001665758_1 ENSG00000141510 7 of 11 CM973401, TP53_g.13386C>T, TP53_g.13386del, TP53_g.13386C>A, COSM10771, COSM44476, COSM45344, COSM212112, COSM212255, COSM212254, COSM212111, COSM3378345, COSM1646862 deleterious(0) probably_damaging(1) 80 Blank GGATG G/A GCCTC NTC_011 FLD0360 FLD0384 3_prime_UTR TP53 c.*40C>T chr17 7572887 G A =hyperlink("http://localhost:60151/goto?locus=chr17:7572887", "IGV") low 0.400 9 pass no call 44 TP53_E00001757276_1 ENSG00000141510 11 of 11 18 Blank GATGG G/A GGTGG